<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE biosystems SYSTEM "rssm.dtd">

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  <source>Reactome</source>
  <sourceurl>http://www.reactome.org</sourceurl>
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    <citation>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <gene>
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      <gene>
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        <name>CSNK2A1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>SLC38A9</name>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <name>DYNLL2</name>
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          </protein>
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      </gene>
      <gene>
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        <name>TSC1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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        <name>USP30</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>PINK1</name>
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      <gene>
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        <name>UBE2D2</name>
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          </protein>
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      <gene>
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        <name>CFTR</name>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>Q2LL38</externalid>
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        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1632852</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9612973</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1632852</externalid>
    <name>Macroautophagy</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1632852</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>9619732</externalid>
        <name>TUBB2A</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>reactive oxygen species</name>
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      <smallmolecule>
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      <smallmolecule>
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        <name>water</name>
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      </smallmolecule>
      <smallmolecule>
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          <externalid>37565</externalid>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      <smallmolecule>
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          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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          <externalid>57880</externalid>
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      <linkedsystem>
        <externalid>R-BTA-9612973</externalid>
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    <name>Selective autophagy</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9663891</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SRC</name>
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              <externalid>E1BIM8</externalid>
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      <linkedsystem>
        <externalid>R-BTA-1632852</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5205647</externalid>
    <name>Mitophagy</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5205647</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376326</externalid>
        <name>VDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P45879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376387</externalid>
        <name>TOMM70A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376367</externalid>
        <name>TOMM22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376359</externalid>
        <name>PINK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405311</externalid>
        <name>FUNDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376375</externalid>
        <name>TOMM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8YXZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368756</externalid>
        <name>OPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327967</externalid>
        <name>SQSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376383</externalid>
        <name>TOMM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376396</externalid>
        <name>ATG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358922</externalid>
        <name>ULK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388322</externalid>
        <name>VDAC5P</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H783</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352827</externalid>
        <name>MFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7GLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376321</externalid>
        <name>MTERF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384091</externalid>
        <name>ATG9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T904</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376400</externalid>
        <name>ATG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MQ24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376331</externalid>
        <name>TOMM20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376336</externalid>
        <name>VDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68002</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376345</externalid>
        <name>MAP1LC3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376349</externalid>
        <name>MAP1LC3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O41515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376379</externalid>
        <name>TOMM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376371</externalid>
        <name>TOMM40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PGAM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5205685</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8934903</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9663891</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>PINK1-PRKN Mediated Mitophagy</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5205685</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376326</externalid>
        <name>VDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P45879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376387</externalid>
        <name>TOMM70A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376367</externalid>
        <name>TOMM22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376359</externalid>
        <name>PINK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376375</externalid>
        <name>TOMM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8YXZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368756</externalid>
        <name>OPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327967</externalid>
        <name>SQSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376383</externalid>
        <name>TOMM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATG12</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MZE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388322</externalid>
        <name>VDAC5P</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H783</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352827</externalid>
        <name>MFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7GLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376321</externalid>
        <name>MTERF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384091</externalid>
        <name>ATG9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T904</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376400</externalid>
        <name>ATG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MQ24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376331</externalid>
        <name>TOMM20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376336</externalid>
        <name>VDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68002</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376345</externalid>
        <name>MAP1LC3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376349</externalid>
        <name>MAP1LC3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O41515</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TOMM6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q56JY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB5</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
    </genes>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-5205685</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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    </linkedsystems>
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      <organism_specific_biosystem />
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          </protein>
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          <protein>
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            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
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          <protein>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <linkedsystem>
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          <linked />
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          <protein>
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          <protein>
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      <smallmolecule>
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      <linkedsystem>
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      </gene>
      <gene>
        <externalid>10388278</externalid>
        <name>USP30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9664873</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9663891</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963743</externalid>
    <name>Digestion and absorption</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963743</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326884</externalid>
        <name>SI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327792</externalid>
        <name>PNLIPRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389680</externalid>
        <name>CHIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326897</externalid>
        <name>LCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403594</externalid>
        <name>GUCY2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407435</externalid>
        <name>LIPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MES3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403584</externalid>
        <name>GUCA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326873</externalid>
        <name>LOC539383</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326925</externalid>
        <name>SLC2A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327772</externalid>
        <name>CLPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326869</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334064</externalid>
        <name>NPC1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327761</externalid>
        <name>CEL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407439</externalid>
        <name>PNLIPRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326909</externalid>
        <name>MGAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327796</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403267</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403588</externalid>
        <name>GUCA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406907</externalid>
        <name>PIR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342520</externalid>
        <name>SLC5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29832</externalid>
        <name>isomaltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189011</externalid>
        <name>limit dextrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8953384</externalid>
        <name>quercetin-7-olate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786440</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8979599</externalid>
        <name>2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114786</externalid>
        <name>aldehydo-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17118</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32323</externalid>
        <name>alpha-maltotriose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786432</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8935690</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963676</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8963743</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8935690</externalid>
    <name>Digestion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8935690</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10326884</externalid>
        <name>SI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327792</externalid>
        <name>PNLIPRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389680</externalid>
        <name>CHIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326897</externalid>
        <name>LCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403594</externalid>
        <name>GUCY2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407435</externalid>
        <name>LIPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MES3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403584</externalid>
        <name>GUCA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326873</externalid>
        <name>LOC539383</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327772</externalid>
        <name>CLPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326869</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327761</externalid>
        <name>CEL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407439</externalid>
        <name>PNLIPRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326909</externalid>
        <name>MGAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327796</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403267</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403588</externalid>
        <name>GUCA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406907</externalid>
        <name>PIR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29832</externalid>
        <name>isomaltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189011</externalid>
        <name>limit dextrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8953384</externalid>
        <name>quercetin-7-olate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786440</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8979599</externalid>
        <name>2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114786</externalid>
        <name>aldehydo-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17118</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32323</externalid>
        <name>alpha-maltotriose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786432</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-192456</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-189085</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8935690</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963743</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-192456</externalid>
    <name>Digestion of dietary lipid</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-192456</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327792</externalid>
        <name>PNLIPRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327761</externalid>
        <name>CEL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407439</externalid>
        <name>PNLIPRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407435</externalid>
        <name>LIPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MES3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327796</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327772</externalid>
        <name>CLPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-192456</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8935690</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-189085</externalid>
    <name>Digestion of dietary carbohydrate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-189085</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326869</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326884</externalid>
        <name>SI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389680</externalid>
        <name>CHIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326897</externalid>
        <name>LCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326909</externalid>
        <name>MGAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326873</externalid>
        <name>LOC539383</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29832</externalid>
        <name>isomaltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32323</externalid>
        <name>alpha-maltotriose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114786</externalid>
        <name>aldehydo-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17118</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189011</externalid>
        <name>limit dextrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786432</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786440</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-189085</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8935690</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963676</externalid>
    <name>Intestinal absorption</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963676</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334064</externalid>
        <name>NPC1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326925</externalid>
        <name>SLC2A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342520</externalid>
        <name>SLC5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114786</externalid>
        <name>aldehydo-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17118</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8963678</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8981373</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8963676</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963743</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963678</externalid>
    <name>Intestinal lipid absorption</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963678</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334064</externalid>
        <name>NPC1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963678</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963676</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8981373</externalid>
    <name>Intestinal hexose absorption</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8981373</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326925</externalid>
        <name>SLC2A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342520</externalid>
        <name>SLC5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114786</externalid>
        <name>aldehydo-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17118</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8981373</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963676</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Programmed Cell Death</name>
    <biosystemtype>
      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5357801</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <externalid>10325754</externalid>
        <name>CLSPN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF69</externalid>
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          </protein>
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      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
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          </protein>
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      <gene>
        <externalid>10320651</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10316895</externalid>
        <name>YWHAQ</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401265</externalid>
        <name>OPA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBC4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333050</externalid>
        <name>DFFB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2E0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYCS</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1BE56</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FADD</name>
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              <externalid>Q645M6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DIABLO</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>APPL1</name>
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          <protein>
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              <externalid>A5PKI0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FNTA</name>
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          <protein>
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              <externalid>F1N081</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          <protein>
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              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BIRC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YWHAH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FLOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380059</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STK24</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VE07</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DYNLL1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NMT1</name>
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          <protein>
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              <externalid>F1MZK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313725</externalid>
        <name>FASLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DSG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM91</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
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          </protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334594</externalid>
        <name>DNM1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320564</externalid>
        <name>LOC508646</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330541</externalid>
        <name>DSP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335101</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380067</externalid>
        <name>PDCD6IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320063</externalid>
        <name>APAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330559</externalid>
        <name>GAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4Q5</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9693325</externalid>
        <name>diethyldithiocarbamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144353</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-109581</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5218859</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5357801</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Apoptosis</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-109581</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>CLSPN</name>
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              <externalid>A0A3Q1LF69</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1NJ55</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3SZI4</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>KPNA1</name>
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              <externalid>A2VE08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>F1MB04</externalid>
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      <gene>
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              <externalid>A0A3Q1MXU1</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>F1MZX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DFFB</name>
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              <externalid>F1N2E0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYCS</name>
        <entity>
          <protein>
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              <externalid>P62894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334216</externalid>
        <name>HMGB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40673</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
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              <externalid>E1BE56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YWHAG</name>
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              <externalid>A7Z057</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1MQG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HMGB1</name>
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          <protein>
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              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FADD</name>
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              <externalid>Q645M6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>BAK1</name>
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              <externalid>Q05KI7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DIABLO</name>
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              <externalid>Q2NL36</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>APPL1</name>
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              <externalid>A5PKI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FNTA</name>
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          <protein>
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              <externalid>F1N081</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TICAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333872</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YWHAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PKP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320617</externalid>
        <name>BMF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334565</externalid>
        <name>STK24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333054</externalid>
        <name>DFFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323483</externalid>
        <name>TLR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6WCD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331489</externalid>
        <name>DSG1</name>
        <entity>
          <protein>
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              <externalid>F1MIW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320647</externalid>
        <name>DYNLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GSDME</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321153</externalid>
        <name>NMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330487</externalid>
        <name>GSN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1I6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FASLG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PMAIP1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DSG3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CTNNB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>KPNB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>BCAP31</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>STK26</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VIM</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>OCLN</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>GSDMD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>SATB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10330467</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10320103</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLEC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRS3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>APIP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>TRADD</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CASP9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU2</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
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          </protein>
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      <gene>
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        <name>SFN</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>BMX</name>
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              <sourcename>UniProt</sourcename>
              <externalid>G3X680</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
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          </protein>
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      <gene>
        <externalid>10331523</externalid>
        <name>SH3GLB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10320575</externalid>
        <name>BAD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
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          </protein>
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      <gene>
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        <name>CD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
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          </protein>
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      <gene>
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        <name>PPP3CC</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>YWHAZ</name>
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      <gene>
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          </protein>
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      <gene>
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        <name>LOC508646</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>OMA1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN3</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>DSP</name>
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            <xref>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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        <name>YWHAB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
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      <gene>
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        <name>BIRC2</name>
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          </protein>
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      <gene>
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        <name>SPTAN1</name>
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      <gene>
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        <name>CDH1</name>
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          </protein>
        </entity>
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      <gene>
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        <name>MAPK8</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>XIAP</name>
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      <gene>
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      <gene>
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        <name>YWHAE</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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        <name>lipopolysaccharide</name>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <externalid>29105</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
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          <externalid>28494</externalid>
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      </smallmolecule>
    </smallmolecules>
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        <externalid>R-BTA-5357769</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75153</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-109581</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5357801</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-5357769</externalid>
    <name>Caspase activation via extrinsic apoptotic signalling pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5357769</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RIPK1</name>
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              <externalid>Q3SZK6</externalid>
            </xref>
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      <gene>
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        <name>CASP8</name>
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              <externalid>Q2LGB8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TRADD</name>
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              <externalid>Q2KI74</externalid>
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      <gene>
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        <name>CASP3</name>
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              <externalid>F1MB04</externalid>
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      </gene>
      <gene>
        <externalid>10320073</externalid>
        <name>CASP9</name>
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          <protein>
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              <externalid>E1BNU2</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MC37</externalid>
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      <gene>
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        <name>TLR4</name>
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              <externalid>Q6WCD5</externalid>
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          </protein>
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      <gene>
        <externalid>10317323</externalid>
        <entity>
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              <externalid>E1BE56</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FAS</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320134</externalid>
        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320142</externalid>
        <name>BAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320606</externalid>
        <name>PPP3CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320564</externalid>
        <name>LOC508646</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320183</externalid>
        <name>BID</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316877</externalid>
        <name>YWHAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320617</externalid>
        <name>BMF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320647</externalid>
        <name>DYNLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321153</externalid>
        <name>NMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320683</externalid>
        <name>PMAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NFP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320063</externalid>
        <name>APAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-75108</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114452</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111453</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114294</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111452</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111471</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-109606</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109581</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75108</externalid>
    <name>Activation, myristolyation of BID and translocation to mitochondria</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75108</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320183</externalid>
        <name>BID</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321153</externalid>
        <name>NMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320564</externalid>
        <name>LOC508646</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75108</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-114452</externalid>
    <name>Activation of BH3-only proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-114452</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320183</externalid>
        <name>BID</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316877</externalid>
        <name>YWHAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316895</externalid>
        <name>YWHAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320651</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320617</externalid>
        <name>BMF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316889</externalid>
        <name>SFN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316883</externalid>
        <name>YWHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z057</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320647</externalid>
        <name>DYNLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320575</externalid>
        <name>BAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320606</externalid>
        <name>PPP3CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320683</externalid>
        <name>PMAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NFP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111447</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111448</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111446</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-139910</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-114452</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111447</externalid>
    <name>Activation of BAD and translocation to mitochondria</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111447</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320183</externalid>
        <name>BID</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316883</externalid>
        <name>YWHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z057</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316877</externalid>
        <name>YWHAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320575</externalid>
        <name>BAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316895</externalid>
        <name>YWHAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320606</externalid>
        <name>PPP3CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316889</externalid>
        <name>SFN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC36</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111447</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114452</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111448</externalid>
    <name>Activation of NOXA and translocation to mitochondria</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111448</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320683</externalid>
        <name>PMAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NFP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111448</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114452</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111446</externalid>
    <name>Activation of BIM and translocation to mitochondria</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111446</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320647</externalid>
        <name>DYNLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320651</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111446</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114452</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-139910</externalid>
    <name>Activation of BMF and translocation to mitochondria</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-139910</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320617</externalid>
        <name>BMF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-139910</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114452</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111453</externalid>
    <name>BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111453</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320183</externalid>
        <name>BID</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320575</externalid>
        <name>BAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320651</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320683</externalid>
        <name>PMAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NFP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320617</externalid>
        <name>BMF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111453</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-114294</externalid>
    <name>Activation, translocation and oligomerization of BAX</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-114294</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
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        <name>BID</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BAX</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111452</externalid>
    <name>Activation and oligomerization of BAK protein</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111452</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>BID</name>
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              <externalid>Q17QH5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111452</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111471</externalid>
    <name>Apoptotic factor-mediated response</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111471</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
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        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320103</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320099</externalid>
        <name>APIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395300</externalid>
        <name>SEPTIN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320073</externalid>
        <name>CASP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320134</externalid>
        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320142</externalid>
        <name>BAX</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320063</externalid>
        <name>APAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111457</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111461</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111469</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111471</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109606</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111457</externalid>
    <name>Release of apoptotic factors from the mitochondria</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320134</externalid>
        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320142</externalid>
        <name>BAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395300</externalid>
        <name>SEPTIN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111457</externalid>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Cytochrome c-mediated apoptotic response</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CASP7</name>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320099</externalid>
        <name>APIP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320073</externalid>
        <name>CASP9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320063</externalid>
        <name>APAF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111458</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111459</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111461</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111471</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111458</externalid>
    <name>Formation of apoptosome</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320103</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320099</externalid>
        <name>APIP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320073</externalid>
        <name>CASP9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320063</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
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          </protein>
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      <gene>
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        <name>CYCS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
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          </protein>
        </entity>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-9627069</externalid>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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  <biosystem>
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      <organism_specific_biosystem />
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      <taxnode>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VCJ2</externalid>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7I8</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
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          </protein>
        </entity>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
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      </linkedsystem>
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    <name>Activation of caspases through apoptosome-mediated cleavage</name>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
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          </protein>
        </entity>
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        <name>ADP(3-)</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111461</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>SMAC, XIAP-regulated apoptotic response</name>
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    </biosystemtype>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>CASP7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>XIAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CASP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395300</externalid>
        <name>SEPTIN4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-BTA-111463</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111464</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111469</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111471</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111463</externalid>
    <name>SMAC (DIABLO) binds to IAPs</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111463</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111463</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111469</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111464</externalid>
    <name>SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
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              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320175</externalid>
        <name>DIABLO</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111464</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111469</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75153</externalid>
    <name>Apoptotic execution phase</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10325754</externalid>
        <name>CLSPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334534</externalid>
        <name>OCLN</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A2VE81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334696</externalid>
        <name>SATB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330467</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333085</externalid>
        <name>KPNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330549</externalid>
        <name>PLEC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333050</externalid>
        <name>DFFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334216</externalid>
        <name>HMGB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40673</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334506</externalid>
        <name>BMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330510</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331523</externalid>
        <name>SH3GLB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330569</externalid>
        <name>FNTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N081</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334594</externalid>
        <name>DNM1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333872</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330541</externalid>
        <name>DSP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334526</externalid>
        <name>TJP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333864</externalid>
        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330448</externalid>
        <name>PKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331533</externalid>
        <name>SPTAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331499</externalid>
        <name>CDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333054</externalid>
        <name>DFFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334565</externalid>
        <name>STK24</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DSG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330487</externalid>
        <name>GSN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328454</externalid>
        <name>APC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV51</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>CTNNB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DSG3</name>
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          <protein>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>KPNB1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BCAP31</name>
        <entity>
          <protein>
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              <externalid>Q5E9F1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STK26</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VIM</name>
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          <protein>
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              <externalid>P48616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GAS2</name>
        <entity>
          <protein>
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              <externalid>A8E4Q5</externalid>
            </xref>
          </protein>
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      </gene>
    </genes>
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      <linkedsystem>
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        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140342</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109581</externalid>
        <linkedsystemtype>
          <superset />
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Apoptotic cleavage of cellular proteins</name>
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              <externalid>A0A3Q1LF69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OCLN</name>
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          <protein>
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              <externalid>A2VE81</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>E1BHK2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLEC</name>
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              <externalid>A0A3Q1MRS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
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              <externalid>F1MB04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
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              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334506</externalid>
        <name>BMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330510</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331523</externalid>
        <name>SH3GLB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330569</externalid>
        <name>FNTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N081</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333872</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330541</externalid>
        <name>DSP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334526</externalid>
        <name>TJP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333864</externalid>
        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330448</externalid>
        <name>PKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331533</externalid>
        <name>SPTAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331499</externalid>
        <name>CDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334565</externalid>
        <name>STK24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331489</externalid>
        <name>DSG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330487</externalid>
        <name>GSN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328454</externalid>
        <name>APC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330520</externalid>
        <name>DSG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334552</externalid>
        <name>BCAP31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334420</externalid>
        <name>STK26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5W5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330497</externalid>
        <name>VIM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330559</externalid>
        <name>GAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-264870</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351906</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-352238</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111465</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75153</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-264870</externalid>
    <name>Caspase-mediated cleavage of cytoskeletal proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-264870</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320118</externalid>
        <name>CASP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331523</externalid>
        <name>SH3GLB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330487</externalid>
        <name>GSN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330467</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330549</externalid>
        <name>PLEC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331533</externalid>
        <name>SPTAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330497</externalid>
        <name>VIM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333872</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330559</externalid>
        <name>GAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-264870</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111465</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-351906</externalid>
    <name>Apoptotic cleavage of cell adhesion  proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-351906</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330541</externalid>
        <name>DSP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334534</externalid>
        <name>OCLN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331489</externalid>
        <name>DSG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334526</externalid>
        <name>TJP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330448</externalid>
        <name>PKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330520</externalid>
        <name>DSG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331499</externalid>
        <name>CDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-351906</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111465</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-352238</externalid>
    <name>Breakdown of the nuclear lamina</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-352238</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333864</externalid>
        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333872</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-352238</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111465</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140342</externalid>
    <name>Apoptosis induced DNA fragmentation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140342</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333085</externalid>
        <name>KPNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333054</externalid>
        <name>DFFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333050</externalid>
        <name>DFFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334216</externalid>
        <name>HMGB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40673</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-140342</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75153</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-169911</externalid>
    <name>Regulation of Apoptosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-169911</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10401265</externalid>
        <name>OPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401273</externalid>
        <name>OMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-169911</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109581</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5218859</externalid>
    <name>Regulated Necrosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5218859</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371765</externalid>
        <name>OGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316125</externalid>
        <name>FADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q645M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320134</externalid>
        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348621</externalid>
        <name>CHMP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344590</externalid>
        <name>CASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348615</externalid>
        <name>CHMP4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380055</externalid>
        <name>FLOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380059</externalid>
        <name>FLOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348597</externalid>
        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313725</externalid>
        <name>FASLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348625</externalid>
        <name>CHMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H704</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348607</externalid>
        <name>CHMP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357858</externalid>
        <name>ELA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313729</externalid>
        <name>FAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348603</externalid>
        <name>CHMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320142</externalid>
        <name>BAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344030</externalid>
        <name>IL1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08831</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320564</externalid>
        <name>LOC508646</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344619</externalid>
        <name>IL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380067</externalid>
        <name>PDCD6IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360803</externalid>
        <name>CDC37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
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    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9693325</externalid>
        <name>diethyldithiocarbamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144353</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5213460</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620971</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5218859</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5357801</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5213460</externalid>
    <name>RIPK1-mediated regulated necrosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5213460</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371765</externalid>
        <name>OGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313729</externalid>
        <name>FAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316125</externalid>
        <name>FADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q645M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380055</externalid>
        <name>FLOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380059</externalid>
        <name>FLOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380067</externalid>
        <name>PDCD6IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360803</externalid>
        <name>CDC37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313725</externalid>
        <name>FASLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5675482</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5213460</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5218859</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5675482</externalid>
    <name>Regulation of necroptotic cell death</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5675482</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371765</externalid>
        <name>OGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313729</externalid>
        <name>FAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316125</externalid>
        <name>FADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q645M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380055</externalid>
        <name>FLOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380059</externalid>
        <name>FLOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380067</externalid>
        <name>PDCD6IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360803</externalid>
        <name>CDC37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313725</externalid>
        <name>FASLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5218900</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5675482</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5213460</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5218900</externalid>
    <name>CASP8 activity is inhibited</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5218900</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316125</externalid>
        <name>FADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q645M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313725</externalid>
        <name>FASLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313729</externalid>
        <name>FAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5218900</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5675482</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5620971</externalid>
    <name>Pyroptosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5620971</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348625</externalid>
        <name>CHMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H704</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348607</externalid>
        <name>CHMP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344590</externalid>
        <name>CASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348615</externalid>
        <name>CHMP4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357858</externalid>
        <name>ELA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348597</externalid>
        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344619</externalid>
        <name>IL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320134</externalid>
        <name>BAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KI7</externalid>
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          </protein>
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      <gene>
        <externalid>10320142</externalid>
        <name>BAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348603</externalid>
        <name>CHMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS7</externalid>
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          </protein>
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      <gene>
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        <name>IL1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>CHMP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
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          </protein>
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      <gene>
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        <name>LOC508646</name>
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          <protein>
            <xref>
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              <externalid>F1MTF4</externalid>
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    <smallmolecules>
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        <externalid>9760917</externalid>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9693325</externalid>
        <name>diethyldithiocarbamic acid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>144353</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5620971</externalid>
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          <linked />
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      <linkedsystem>
        <externalid>R-BTA-5218859</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>Hemostasis</name>
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    <url>http://www.reactome.org/content/detail/R-BTA-109582</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>THBS1</name>
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          <protein>
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              <externalid>A0A3Q1MQV3</externalid>
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      <gene>
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        <name>TGFB1</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1N449</externalid>
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          </protein>
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      <gene>
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        <name>GNA13</name>
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          <protein>
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              <externalid>G5E6P3</externalid>
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      <gene>
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        <name>RACGAP1</name>
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          <protein>
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              <externalid>A0A3Q1N6B9</externalid>
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      <gene>
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        <name>HMG20B</name>
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          <protein>
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              <externalid>Q32L68</externalid>
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          </protein>
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      <gene>
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              <externalid>E1B8P9</externalid>
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      <gene>
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              <externalid>Q148M9</externalid>
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      <gene>
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        <name>PPP2R5D</name>
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              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>Q3T0F9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1N7J2</externalid>
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          </protein>
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      <gene>
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        <name>ISLR</name>
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              <externalid>A4IFA6</externalid>
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          </protein>
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      <gene>
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              <externalid>A4IFB7</externalid>
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      <gene>
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              <externalid>Q08DS6</externalid>
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          </protein>
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      <gene>
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              <externalid>E1BGA9</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MZ56</externalid>
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          </protein>
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      <gene>
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              <externalid>P84227</externalid>
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      <gene>
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              <externalid>A0A3Q1MAA1</externalid>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MKS5</externalid>
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      <gene>
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              <externalid>E1BMQ6</externalid>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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              <externalid>A2VDZ0</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>A4IF69</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>F1MBA2</externalid>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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              <externalid>F1MWR7</externalid>
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          </protein>
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      <gene>
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              <externalid>Q0P5G6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>F13B</name>
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              <externalid>Q2TBQ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>F1MNQ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>F1MQJ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNAT3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LCK</name>
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              <externalid>Q3ZCM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DGKZ</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1N653</externalid>
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          </protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MIF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331449</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353074</externalid>
        <name>DOCK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346112</externalid>
        <name>RAB27B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352882</externalid>
        <name>ITPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345878</externalid>
        <name>APOL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346277</externalid>
        <name>HABP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RT22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342905</externalid>
        <name>ACTN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B7N2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328359</externalid>
        <name>VEGFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320351</externalid>
        <name>COL1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02465</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345918</externalid>
        <name>TOR4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320525</externalid>
        <name>P2RX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760797</externalid>
        <name>1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>977192</externalid>
        <name>glycosaminoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869217</externalid>
        <name>1-octadecylglycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9857979</externalid>
        <name>polyphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114958</externalid>
        <name>single-stranded DNA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9160</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-418346</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75892</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140877</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75205</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202733</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983231</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-109582</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418346</externalid>
    <name>Platelet homeostasis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418346</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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          </protein>
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      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869217</externalid>
        <name>1-octadecylglycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-392851</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392154</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418360</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-432142</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418346</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392851</externalid>
    <name>Prostacyclin signalling through prostacyclin receptor</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392851</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336247</externalid>
        <name>PTGIR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-392851</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392154</externalid>
    <name>Nitric oxide stimulates guanylate cyclase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392154</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340609</externalid>
        <name>IRAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340635</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N569</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>149338</externalid>
        <name>PRKG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00516</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340622</externalid>
        <name>PRKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340600</externalid>
        <name>NOS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340649</externalid>
        <name>PDE11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340594</externalid>
        <name>NOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6M2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340631</externalid>
        <name>PDE5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340641</externalid>
        <name>PDE2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340645</externalid>
        <name>PDE10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-418457</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-392154</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418457</externalid>
    <name>cGMP effects</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418457</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
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        <name>IRAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH42</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340631</externalid>
        <name>PDE5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28156</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340635</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N569</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>149338</externalid>
        <name>PRKG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00516</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340622</externalid>
        <name>PRKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340649</externalid>
        <name>PDE11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPD8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340641</externalid>
        <name>PDE2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MZ56</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340645</externalid>
        <name>PDE10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW13</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-418457</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392154</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418360</externalid>
    <name>Platelet calcium homeostasis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418360</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320541</externalid>
        <name>P2RX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUF3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340560</externalid>
        <name>ATP2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN60</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340556</externalid>
        <name>ATP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7J2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341677</externalid>
        <name>SLC8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7D0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320537</externalid>
        <name>P2RX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9U1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340564</externalid>
        <name>ATP2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320529</externalid>
        <name>P2RX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIH1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341681</externalid>
        <name>SLC8A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340577</externalid>
        <name>ATP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341859</externalid>
        <name>TRPC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYW0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341855</externalid>
        <name>TRPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341673</externalid>
        <name>SLC8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320545</externalid>
        <name>P2RX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B742</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320533</externalid>
        <name>P2RX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7A9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340585</externalid>
        <name>ATP2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340581</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340568</externalid>
        <name>ATP2B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3K0R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320549</externalid>
        <name>P2RX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320525</externalid>
        <name>P2RX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-139853</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418359</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418360</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-139853</externalid>
    <name>Elevation of cytosolic Ca2+ levels</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>TRPC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341855</externalid>
        <name>TRPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320545</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B742</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320541</externalid>
        <name>P2RX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUF3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320533</externalid>
        <name>P2RX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7A9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320537</externalid>
        <name>P2RX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320549</externalid>
        <name>P2RX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320529</externalid>
        <name>P2RX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320525</externalid>
        <name>P2RX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-139853</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418360</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418359</externalid>
    <name>Reduction of cytosolic Ca++ levels</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10340577</externalid>
        <name>ATP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340560</externalid>
        <name>ATP2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340556</externalid>
        <name>ATP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7J2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341677</externalid>
        <name>SLC8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340585</externalid>
        <name>ATP2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340581</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340568</externalid>
        <name>ATP2B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3K0R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340564</externalid>
        <name>ATP2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS16</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341673</externalid>
        <name>SLC8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341681</externalid>
        <name>SLC8A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST7</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-418359</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418360</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432142</externalid>
    <name>Platelet sensitization by LDL</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332486</externalid>
        <name>PTPN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321250</externalid>
        <name>PPP2R5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343009</externalid>
        <name>FGR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG9</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
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      <gene>
        <externalid>10331309</externalid>
        <name>PECAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHJ9</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10343001</externalid>
        <name>LRP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQW3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
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          </protein>
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      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
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          </protein>
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      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10321238</externalid>
        <name>PPP2R5A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432142</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Platelet Adhesion to exposed collagen</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>FYN</name>
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              <externalid>A0JNB0</externalid>
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          </protein>
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      <gene>
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        <name>LYN</name>
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          <protein>
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              <externalid>F1N261</externalid>
            </xref>
          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>FCER1G</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
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          </protein>
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      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Platelet activation, signaling and aggregation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-76002</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>THBS1</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MQV3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PDPN</name>
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              <externalid>Q402A0</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>G5E6P3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AAMP</name>
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          <protein>
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              <externalid>Q3SZK1</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>VEGFC</name>
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              <externalid>Q9XS50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ENDOD1</name>
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              <externalid>A7YY77</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      </gene>
      <gene>
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              <externalid>A4IFB7</externalid>
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      <gene>
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          <protein>
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              <externalid>Q08DS6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>Q9TU25</externalid>
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        </entity>
      </gene>
      <gene>
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              <externalid>E1BGA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1B863</externalid>
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          </protein>
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      <gene>
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        <name>GP9</name>
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              <externalid>F1N1G4</externalid>
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      <gene>
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              <externalid>E1B7U7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFB2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P21214</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SCCPDH</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MX05</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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        <name>hydron</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>arachidonate</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9857979</externalid>
        <name>polyphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-430116</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392518</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-456926</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114604</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76009</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114508</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76005</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-76002</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-430116</externalid>
    <name>GP1b-IX-V activation signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-430116</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320351</externalid>
        <name>COL1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02465</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320413</externalid>
        <name>GP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320403</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B863</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320409</externalid>
        <name>GP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-430116</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392518</externalid>
    <name>Signal amplification</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392518</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326072</externalid>
        <name>AAMP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336715</externalid>
        <name>TBXA2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336667</externalid>
        <name>P2RY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48042</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337246</externalid>
        <name>P2RY12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-392170</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418592</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428930</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-392518</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392170</externalid>
    <name>ADP signalling through P2Y purinoceptor 12</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392170</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337246</externalid>
        <name>P2RY12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-392170</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392518</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418592</externalid>
    <name>ADP signalling through P2Y purinoceptor 1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418592</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336667</externalid>
        <name>P2RY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48042</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-418592</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392518</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-428930</externalid>
    <name>Thromboxane signalling through TP receptor</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-428930</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326072</externalid>
        <name>AAMP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336715</externalid>
        <name>TBXA2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-428930</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392518</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-456926</externalid>
    <name>Thrombin signalling through proteinase activated receptors (PARs)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-456926</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320259</externalid>
        <name>F2RL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320269</externalid>
        <name>GNA12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336911</externalid>
        <name>F2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320263</externalid>
        <name>F2RL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-456926</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-114604</externalid>
    <name>GPVI-mediated activation cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-114604</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320462</externalid>
        <name>PDPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q402A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345673</externalid>
        <name>MPIG6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320214</externalid>
        <name>RHOG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320208</externalid>
        <name>RAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320331</externalid>
        <name>FCER1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338945</externalid>
        <name>PIK3R6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332486</externalid>
        <name>PTPN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320327</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320455</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320351</externalid>
        <name>COL1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02465</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-114604</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76009</externalid>
    <name>Platelet Aggregation (Plug Formation)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-76009</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334813</externalid>
        <name>RASGRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6N9I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334753</externalid>
        <name>TLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334740</externalid>
        <name>APBB1IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334112</externalid>
        <name>RAPGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-354192</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392023</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-76009</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-354192</externalid>
    <name>Integrin signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-354192</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334740</externalid>
        <name>APBB1IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334813</externalid>
        <name>RASGRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6N9I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334753</externalid>
        <name>TLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334112</externalid>
        <name>RAPGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-354194</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-372708</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-354192</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76009</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-354194</externalid>
    <name>GRB2:SOS provides linkage to MAPK signaling for Integrins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-354194</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334740</externalid>
        <name>APBB1IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334753</externalid>
        <name>TLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-354194</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-354192</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-372708</externalid>
    <name>p130Cas linkage to MAPK signaling for integrins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-372708</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334740</externalid>
        <name>APBB1IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334753</externalid>
        <name>TLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-372708</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-354192</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392023</externalid>
    <name>Adrenaline signalling through Alpha-2 adrenergic receptor</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392023</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-392023</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76009</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-114508</externalid>
    <name>Effects of PIP2 hydrolysis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-114508</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387746</externalid>
        <name>ABHD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341859</externalid>
        <name>TRPC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341855</externalid>
        <name>TRPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387750</externalid>
        <name>ABHD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341888</externalid>
        <name>DGKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341872</externalid>
        <name>DGKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341724</externalid>
        <name>PRKCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341892</externalid>
        <name>DGKI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341803</externalid>
        <name>MGLL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341884</externalid>
        <name>DGKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341790</externalid>
        <name>DAGLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341900</externalid>
        <name>DGKQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341794</externalid>
        <name>DAGLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RA94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341904</externalid>
        <name>DGKZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N653</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341880</externalid>
        <name>DGKD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341896</externalid>
        <name>DGKK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCG9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10341876</externalid>
        <name>DGKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7U7</externalid>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-426048</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-114508</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-416476</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-426048</externalid>
    <name>Arachidonate production from DAG</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-426048</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ABHD12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DW9</externalid>
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          </protein>
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      <gene>
        <externalid>10341803</externalid>
        <name>MGLL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC02</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ABHD6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZ86</externalid>
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      <gene>
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        <name>DAGLA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BBV2</externalid>
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      <gene>
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        <name>DAGLB</name>
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          <protein>
            <xref>
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              <externalid>F6RA94</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>glycerol</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
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      <smallmolecule>
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        <name>hydron</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
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          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-426048</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114508</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76005</externalid>
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>THBS1</name>
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              <externalid>A0A3Q1MQV3</externalid>
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          </protein>
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      <gene>
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        <name>TGFB1</name>
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          <protein>
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              <externalid>A0A3Q1N449</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10346044</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGQ6</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>VEGFC</name>
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              <externalid>Q9XS50</externalid>
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      <gene>
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              <externalid>A7YY77</externalid>
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      <gene>
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        <name>agp</name>
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              <externalid>Q5GN72</externalid>
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      <gene>
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              <externalid>E1BMJ0</externalid>
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      <gene>
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          <protein>
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              <externalid>P28800</externalid>
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          </protein>
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      <gene>
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        <name>ISLR</name>
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              <externalid>A4IFA6</externalid>
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      <gene>
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      <gene>
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        <name>A1BG</name>
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              <externalid>Q2KJF1</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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              <externalid>F1MX05</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LEFTY2</name>
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              <externalid>E1BH14</externalid>
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          </protein>
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      <gene>
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        <name>FERMT3</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VWF</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>CYB5R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTN2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PECAM1</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>PCYOX1L</name>
        <entity>
          <protein>
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              <externalid>A0A452DIX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>F8</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>NHLRC2</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>SOD1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00442</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>AHSG</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>LAMP2</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1LTK9</externalid>
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          </protein>
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        <externalid>10321746</externalid>
        <name>KNG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342905</externalid>
        <name>ACTN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B7N2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346172</externalid>
        <name>LHFPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344821</externalid>
        <name>STXBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324947</externalid>
        <name>CLU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17697</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328359</externalid>
        <name>VEGFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346056</externalid>
        <name>CLEC3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MMRN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2H1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TOR4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7J5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TMX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9857979</externalid>
        <name>polyphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-114516</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-114608</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-76005</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-114516</externalid>
    <name>Disinhibition of SNARE formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-114516</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10320423</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MXB4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>STX4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIB2</externalid>
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          </protein>
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      <gene>
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        <name>PRKCB</name>
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    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-114516</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76005</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>Platelet degranulation</name>
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      <organism_specific_biosystem />
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      <taxnode>
        <taxid>9913</taxid>
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        <name>THBS1</name>
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          <protein>
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              <externalid>A0A3Q1MQV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324463</externalid>
        <name>TGFB1</name>
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          <protein>
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              <externalid>A0A3Q1N449</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>A0A3Q1MGQ6</externalid>
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          </protein>
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      <gene>
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        <name>CHID1</name>
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          <protein>
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              <externalid>Q5EAB4</externalid>
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          </protein>
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      <gene>
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        <name>VEGFC</name>
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              <externalid>Q9XS50</externalid>
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      <gene>
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        <name>ENDOD1</name>
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              <externalid>A7YY77</externalid>
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      <gene>
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        <name>agp</name>
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      <gene>
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              <externalid>E1BMJ0</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>Q2KJF1</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>F1MX05</externalid>
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      <gene>
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      <gene>
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              <externalid>Q32LP0</externalid>
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          </protein>
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      <gene>
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        <name>VWF</name>
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              <externalid>A0A3Q1LLU1</externalid>
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          </protein>
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      <gene>
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              <externalid>P81948</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CYB5R1</name>
        <entity>
          <protein>
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              <externalid>Q3MHW9</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1MD83</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ACTN2</name>
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          <protein>
            <xref>
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              <externalid>Q3ZC55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PECAM1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHJ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PCYOX1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>F1MKS5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>F8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5W1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NHLRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346267</externalid>
        <name>SOD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00442</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AHSG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12763</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>A0A3Q1LTK9</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>LAMP2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8P4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SELP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTG1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RARRES2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RS5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
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          </protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345918</externalid>
        <name>TOR4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346156</externalid>
        <name>TMX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9857979</externalid>
        <name>polyphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-114608</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76005</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140877</externalid>
    <name>Formation of Fibrin Clot (Clotting Cascade)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140877</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344509</externalid>
        <name>PRTN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320707</externalid>
        <name>F13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321750</externalid>
        <name>C1QBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321831</externalid>
        <name>SERPING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321065</externalid>
        <name>PROCR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07224</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331305</externalid>
        <name>CD177</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320719</externalid>
        <name>SERPIND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R4P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320403</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B863</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320867</externalid>
        <name>F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30931</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321704</externalid>
        <name>F11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LT55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320409</externalid>
        <name>GP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320703</externalid>
        <name>F13A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320766</externalid>
        <name>SERPINE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336911</externalid>
        <name>F2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321789</externalid>
        <name>F12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321746</externalid>
        <name>KNG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321075</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320965</externalid>
        <name>TFPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321082</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320735</externalid>
        <name>SERPINA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320413</externalid>
        <name>GP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321674</externalid>
        <name>F8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5W1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320725</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320819</externalid>
        <name>F5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0I3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321742</externalid>
        <name>KLKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321770</externalid>
        <name>PRCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>977192</externalid>
        <name>glycosaminoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-140834</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140837</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140875</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-140877</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140834</externalid>
    <name>Extrinsic Pathway of Fibrin Clot Formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140834</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320965</externalid>
        <name>TFPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320867</externalid>
        <name>F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30931</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-140834</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140877</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140837</externalid>
    <name>Intrinsic Pathway of Fibrin Clot Formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140837</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320766</externalid>
        <name>SERPINE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321789</externalid>
        <name>F12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321746</externalid>
        <name>KNG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320419</externalid>
        <name>VWF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321750</externalid>
        <name>C1QBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321831</externalid>
        <name>SERPING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PROS1</name>
        <entity>
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          </protein>
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      <gene>
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        <name>SERPINA5</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>GP5</name>
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          <protein>
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          </protein>
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        <name>F8</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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        <name>F11</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <smallmolecule>
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      <smallmolecule>
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          <linked />
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        <name>ANGPT1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O18920</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323051</externalid>
        <name>GAS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>93433</externalid>
        <name>ITGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27977</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331305</externalid>
        <name>CD177</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332279</externalid>
        <name>GRB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329648</externalid>
        <name>ITGB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32592</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356202</externalid>
        <name>CD44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331343</externalid>
        <name>LOC101904063</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321075</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBI9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331329</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321082</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331395</externalid>
        <name>CD58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332313</externalid>
        <name>DOK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331309</externalid>
        <name>PECAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHJ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400384</externalid>
        <name>FCAMR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401257</externalid>
        <name>EPCAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEP6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331325</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332297</externalid>
        <name>GRB14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331357</externalid>
        <name>JAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400388</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369535</externalid>
        <name>GLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LL67</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331383</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7U9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331457</externalid>
        <name>SELP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
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          </protein>
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      <gene>
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        <name>SPN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10331321</externalid>
        <name>SIRPA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383694</externalid>
        <name>MIF</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331403</externalid>
        <name>CEACAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ27</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400400</externalid>
        <name>JCHAIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331449</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANGPT2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PIK3R2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
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          </protein>
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      <gene>
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        <name>PIK3CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANGPTL4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2Z4B2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329658</externalid>
        <name>CXADR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WMV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331425</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LFU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329662</externalid>
        <name>JAML</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPH6</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>ITGA4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SHC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332267</externalid>
        <name>TEK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q06807</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TREM1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8C4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJT8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OLR1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L4Z7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331371</externalid>
        <name>MERTK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N381</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YES1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329644</externalid>
        <name>ITGAL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61625</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-210993</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-210990</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-202733</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-210993</externalid>
    <name>Tie2 Signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-210993</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332267</externalid>
        <name>TEK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q06807</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332313</externalid>
        <name>DOK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332325</externalid>
        <name>ANGPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77802</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332263</externalid>
        <name>ANGPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB7</name>
        <entity>
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            <xref>
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              <externalid>Q1RMW5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANGPTL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2Z4B2</externalid>
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          </protein>
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      <smallmolecule>
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        <name>GTP(4-)</name>
        <xref>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-210993</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202733</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-210990</externalid>
    <name>PECAM1 interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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              <externalid>E1BIM8</externalid>
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          </protein>
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      <gene>
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        <name>FYN</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHJ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJT8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
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          </protein>
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      <gene>
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        <name>ITGAV</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
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          </protein>
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      <gene>
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        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
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          </protein>
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      <gene>
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        <name>LYN</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202733</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <externalid>F2Z4J7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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      <gene>
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        <entity>
          <protein>
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              <externalid>F1N0Y3</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1N1G7</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>RACGAP1</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>VPS45</name>
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              <externalid>F1MDA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HMG20B</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GATA6</name>
        <entity>
          <protein>
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              <externalid>F1N1M2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AKAP1</name>
        <entity>
          <protein>
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              <externalid>E1BMU6</externalid>
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          </protein>
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      <gene>
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        <name>MAFG</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A5PJV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIF22</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MG61</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1MJ73</externalid>
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          </protein>
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      <gene>
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        <name>SH2B2</name>
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          <protein>
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              <externalid>F1MRH8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPE</name>
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          <protein>
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              <externalid>E1BG49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIF11</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BF29</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZFPM1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N6T0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352942</externalid>
        <name>GATA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N551</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353048</externalid>
        <name>EHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIF20A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DOCK11</name>
        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KLC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MGC139254</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAD51B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352960</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352902</externalid>
        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353078</externalid>
        <name>DOCK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353021</externalid>
        <name>MAFF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352393</externalid>
        <name>KLC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326833</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353052</externalid>
        <name>EHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321561</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352401</externalid>
        <name>KLC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352946</externalid>
        <name>GATA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353041</externalid>
        <name>AK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08760</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353074</externalid>
        <name>DOCK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353029</externalid>
        <name>MAFK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343864</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353102</externalid>
        <name>DOCK10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352882</externalid>
        <name>ITPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352845</externalid>
        <name>AKAP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353098</externalid>
        <name>DOCK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352906</externalid>
        <name>PHF21A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352435</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352389</externalid>
        <name>KLC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351373</externalid>
        <name>SH2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352827</externalid>
        <name>MFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7GLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352425</externalid>
        <name>RAD51C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353112</externalid>
        <name>RAB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352930</externalid>
        <name>GATA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352934</externalid>
        <name>GATA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353086</externalid>
        <name>DOCK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7E2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352979</externalid>
        <name>JMJD1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N685</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352407</externalid>
        <name>KIF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353017</externalid>
        <name>NFE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353066</externalid>
        <name>DOCK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352938</externalid>
        <name>GATA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352924</externalid>
        <name>ZFPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBZ5</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114958</externalid>
        <name>single-stranded DNA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9160</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760797</externalid>
        <name>1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-983189</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-983231</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-983189</externalid>
    <name>Kinesins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983189</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321284</externalid>
        <name>KIF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352435</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352467</externalid>
        <name>RACGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352411</externalid>
        <name>KIF5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321561</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321598</externalid>
        <name>KIF20A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352401</externalid>
        <name>KLC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352389</externalid>
        <name>KLC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352397</externalid>
        <name>KLC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352441</externalid>
        <name>KIF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352407</externalid>
        <name>KIF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321172</externalid>
        <name>CENPE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352455</externalid>
        <name>KIF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343864</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352393</externalid>
        <name>KLC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-983189</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983231</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9909396</externalid>
    <name>Circadian clock</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9909396</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419903</externalid>
        <name>PER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419915</externalid>
        <name>PER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9932298</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9909396</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9932298</externalid>
    <name>Degradation of CRY and PER proteins</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9932298</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419903</externalid>
        <name>PER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419915</externalid>
        <name>PER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9932298</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1266738</externalid>
    <name>Developmental Biology</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1266738</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340814</externalid>
        <name>JUP</name>
        <entity>
          <protein>
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        <name>ADP(3-)</name>
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      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9859422</externalid>
        <name>P(1),P(4)-bis(5'-adenosyl) tetraphosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58141</externalid>
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      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>428258</externalid>
        <name>ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1861780</externalid>
        <name>carboxylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2299703</externalid>
        <name>keratan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
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          <externalid>57288</externalid>
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      <smallmolecule>
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              <externalid>F1MMQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC42</name>
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              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
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          </protein>
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      <gene>
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              <externalid>F6S0Q2</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2299703</externalid>
        <name>keratan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
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    <name>Axon guidance</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-422475</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>E1BNV7</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      <smallmolecule>
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        <name>GDP(3-)</name>
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          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <externalid>43474</externalid>
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      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>70974</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-376176</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373760</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2682334</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8853659</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8866376</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-422475</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9675108</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-373755</externalid>
    <name>Semaphorin interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-373755</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>SEMA4D</name>
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          <protein>
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              <externalid>A0A3Q1LQU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLXNA2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MIH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339920</externalid>
        <entity>
          <protein>
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              <externalid>F1MSF0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339990</externalid>
        <name>CDK5R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLXNA4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N2P7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TLN1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP35</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B801</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10339967</externalid>
        <name>DPYSL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02675</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340349</externalid>
        <name>RRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERBB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PLXNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340454</externalid>
        <name>SEMA4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY79</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RND1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328541</externalid>
        <name>NRP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331046</externalid>
        <name>PTPRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339963</externalid>
        <name>CRMP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BER6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLXND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343336</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEMA7A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN47</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340466</externalid>
        <name>PLXNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBK2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02399</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10340442</externalid>
        <name>SEMA3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335248</externalid>
        <name>PLXNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340383</externalid>
        <name>ARHGEF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNE2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>FES</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEMA3A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MEW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD72</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPB4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PAK3</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
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          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
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    </biosystemtype>
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    <taxonomy>
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    </taxonomy>
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              <externalid>A0A3Q1LQU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGEF12</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MN47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP35</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B801</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335248</externalid>
        <name>PLXNB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340383</externalid>
        <name>ARHGEF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340349</externalid>
        <name>RRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340230</externalid>
        <name>RND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340856</externalid>
        <name>ROCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW77</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-416550</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-416572</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-400685</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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        <name>RHOA</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340349</externalid>
        <name>RRAS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335221</externalid>
        <name>SEMA4D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340230</externalid>
        <name>RND1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ68</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340360</externalid>
        <name>ARHGAP35</name>
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      </gene>
      <gene>
        <externalid>10335248</externalid>
        <name>PLXNB1</name>
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          <protein>
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              <externalid>E1B7F6</externalid>
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          </protein>
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    </genes>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>water</name>
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        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
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  <biosystem>
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      <taxnode>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQU8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ARHGEF12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN47</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>Q2HJ68</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RHOC</name>
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              <externalid>Q1RMJ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340856</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>ARHGEF11</name>
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      <gene>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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              <externalid>F1MEW1</externalid>
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      <gene>
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        <name>FYN</name>
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      </gene>
      <gene>
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          <protein>
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              <externalid>E1BMX5</externalid>
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      </gene>
      <gene>
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        <name>PLXNA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MIH8</externalid>
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          </protein>
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      </gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIP5K1C</name>
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          <protein>
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              <externalid>A0A3Q1MBL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TLN1</name>
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              <externalid>A0A3Q1MLQ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2P7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N173</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399954</externalid>
    <name>Sema3A PAK dependent Axon repulsion</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>PLXNA2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSP90AA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FES</name>
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          <protein>
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              <externalid>Q5E9H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328541</externalid>
        <name>NRP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX5</externalid>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BC64</externalid>
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      </gene>
      <gene>
        <externalid>10339880</externalid>
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          <protein>
            <xref>
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              <externalid>F1N173</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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            <xref>
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              <externalid>Q08E52</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>A0A3Q1M0G8</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-399954</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399956</externalid>
    <name>CRMPs in Sema3A signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-399956</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10339979</externalid>
        <name>DPYSL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E641</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339875</externalid>
        <name>PLXNA2</name>
        <entity>
          <protein>
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              <externalid>F1MIH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339990</externalid>
        <name>CDK5R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326287</externalid>
        <name>CDK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339885</externalid>
        <name>PLXNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339967</externalid>
        <name>DPYSL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02675</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339864</externalid>
        <name>SEMA3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332512</externalid>
        <name>FES</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DPYSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLXNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFR4</externalid>
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          </protein>
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      <gene>
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        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DPYSL3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328541</externalid>
        <name>NRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339963</externalid>
        <name>CRMP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BER6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339880</externalid>
        <name>PLXNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N173</externalid>
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          </protein>
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    </genes>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-399956</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Other semaphorin interactions</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10340462</externalid>
        <name>SEMA5A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335234</externalid>
        <name>CD72</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPB4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335221</externalid>
        <name>SEMA4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340454</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY79</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10340466</externalid>
        <name>PLXNB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBK2</externalid>
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          </protein>
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      <gene>
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        <name>PTPRC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS9</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW3</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>F1N4C5</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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    </genes>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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      <taxnode>
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    <genes>
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        <name>NRAS</name>
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              <externalid>A5D7R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>GRB2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
    </smallmolecules>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
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      <taxnode>
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    <genes>
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        <name>SRC</name>
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          <protein>
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              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>F1MQ73</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DOCK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EZR</name>
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          <protein>
            <xref>
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              <externalid>P31976</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346775</externalid>
        <name>NTN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB18</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335101</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340216</externalid>
        <name>TRIO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FYN</name>
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          <protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC42</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WASL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-418885</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-376172</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-373752</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>DCC mediated attractive signaling</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
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    </taxonomy>
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        <name>SRC</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRIO</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340725</externalid>
        <name>DOCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10335101</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC37</externalid>
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          </protein>
        </entity>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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      <smallmolecule>
        <externalid>9736415</externalid>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-373752</externalid>
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    </linkedsystems>
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  <biosystem>
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          </protein>
        </entity>
      </gene>
    </genes>
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      </linkedsystem>
      <linkedsystem>
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          <superset />
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      </linkedsystem>
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  <biosystem>
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      <taxnode>
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        <name>UBC</name>
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      <gene>
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              <externalid>A0A3Q1LI98</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QNM7</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>F1MWH8</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNV7</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
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          </protein>
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      <gene>
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        <name>RHOA</name>
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          <protein>
            <xref>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N739</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMM6</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ7</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
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      </smallmolecule>
      <smallmolecule>
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        <name>keratan sulfate</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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      </smallmolecule>
      <smallmolecule>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
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          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>USP33</name>
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              <externalid>A6QNM7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N739</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLIT2</name>
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          <protein>
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              <externalid>F1MLJ7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DAG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9010553</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-376176</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Role of ABL in ROBO-SLIT signaling</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10335773</externalid>
        <name>ABL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335777</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332205</externalid>
        <name>ROBO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332209</externalid>
        <name>SLIT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-428890</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-376176</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8985586</externalid>
    <name>SLIT2:ROBO1 increases RHOA activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8985586</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332205</externalid>
        <name>ROBO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364103</externalid>
        <name>MYO9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332209</externalid>
        <name>SLIT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8985586</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-376176</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-373760</externalid>
    <name>L1CAM interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-373760</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335181</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346723</externalid>
        <name>DNM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403497</externalid>
        <name>GAP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P06836</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326007</externalid>
        <name>SH3GL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403505</externalid>
        <name>LYPLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-437239</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445144</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-447043</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-373760</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-437239</externalid>
    <name>Recycling pathway of L1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-437239</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346723</externalid>
        <name>DNM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326007</externalid>
        <name>SH3GL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-437239</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373760</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-445144</externalid>
    <name>Signal transduction by L1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-445144</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-445144</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373760</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-447043</externalid>
    <name>Neurofascin interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-447043</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335181</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-447043</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373760</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2682334</externalid>
    <name>EPH-Ephrin signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2682334</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>EFNB2</name>
        <entity>
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              <externalid>F1N0M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>APH1B</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHB3</name>
        <entity>
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              <externalid>F1ML02</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EFNA1</name>
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              <externalid>Q3ZC64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOA</name>
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              <externalid>P61585</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHB2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N3R6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340977</externalid>
        <name>NGEF</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHA10</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N6H6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BJS9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PAK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PAK2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ROCK1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GIT1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217376</externalid>
        <name>ARPC2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARPC1A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1JP79</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSEN2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHA7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MMP2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EFNA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSENEN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217383</externalid>
        <name>ARPC1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CQ2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ACTR2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MB62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPHB1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MII5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LYN</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>EPHA5</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>ARHGEF28</name>
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          </protein>
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      <gene>
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        <name>EFNA4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLY0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>217381</externalid>
        <name>ARPC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T035</externalid>
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          </protein>
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      <gene>
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        <name>EFNA5</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F6QH17</externalid>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>EFNB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>EFNB3</name>
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          </protein>
        </entity>
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      <gene>
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        <name>MMP9</name>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FYN</name>
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      </gene>
      <gene>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>EPHA1</name>
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        </entity>
      </gene>
      <gene>
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              <externalid>E1BER5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>EPHA2</name>
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              <externalid>E1BJ31</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CDC42</name>
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      <gene>
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              <externalid>A7MB57</externalid>
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      <gene>
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              <externalid>G3MXH2</externalid>
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        </entity>
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      <gene>
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              <externalid>E1BKY4</externalid>
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          </protein>
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      <gene>
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              <externalid>Q5E9E2</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3928663</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3928662</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3928664</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3928665</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2682334</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3928663</externalid>
    <name>EPHA-mediated growth cone collapse</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3928663</url>
    <taxonomy>
      <taxnode>
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      <smallmolecule>
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      <smallmolecule>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BCL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383274</externalid>
        <name>ARTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383278</externalid>
        <name>GFRA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338953</externalid>
        <name>PIK3CD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332313</externalid>
        <name>DOK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398428</externalid>
        <name>DOK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399989</externalid>
        <name>DOK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339771</externalid>
        <name>RAP1GAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383301</externalid>
        <name>GDNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6S0Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399993</externalid>
        <name>DOK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8853659</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8866376</externalid>
    <name>Reelin signalling pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8866376</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10399945</externalid>
        <name>DAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399819</externalid>
        <name>RELN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399815</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326365</externalid>
        <name>SH3KBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M839</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8866376</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422475</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9619665</externalid>
    <name>EGR2 and SOX10-mediated initiation of Schwann cell myelination</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9619665</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10410815</externalid>
        <name>ADGRG6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9619665</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9675108</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5682910</externalid>
    <name>LGI-ADAM interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5682910</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340274</externalid>
        <name>CACNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340264</externalid>
        <name>CACNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384218</externalid>
        <name>LGI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384208</externalid>
        <name>LGI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384174</externalid>
        <name>ADAM22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384178</externalid>
        <name>ADAM23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340268</externalid>
        <name>CACNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384196</externalid>
        <name>LGI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332890</externalid>
        <name>CACNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384188</externalid>
        <name>LGI4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384182</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384222</externalid>
        <name>STX1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5682910</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Myogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-525793</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10335773</externalid>
        <name>ABL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344739</externalid>
        <name>MYOD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344681</externalid>
        <name>MEF2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344762</externalid>
        <name>TCF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335627</externalid>
        <name>CDH15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335635</externalid>
        <name>CDH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344691</externalid>
        <name>MAPK12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344753</externalid>
        <name>TCF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344735</externalid>
        <name>MYF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17667</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344685</externalid>
        <name>MEF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335613</externalid>
        <name>CDON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344747</externalid>
        <name>MYF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YS80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344743</externalid>
        <name>MYOG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YS81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344715</externalid>
        <name>SPAG9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335609</externalid>
        <name>BOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335621</externalid>
        <name>CTNNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9M0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344719</externalid>
        <name>BNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335631</externalid>
        <name>CDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A5H1ZRH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344758</externalid>
        <name>TCF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MKE7</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUR9</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0M4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT80</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT81</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H4</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1861780</externalid>
        <name>carboxylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
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          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>428258</externalid>
        <name>ceramide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6805567</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6809371</externalid>
    <name>Formation of the cornified envelope</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6809371</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>JUP</name>
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      <gene>
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              <externalid>F1MGR5</externalid>
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      <gene>
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      <gene>
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      <gene>
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        <name>DSC1</name>
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      <gene>
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      <gene>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>LOC515823</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>PKP1</name>
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          </protein>
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      <gene>
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      <gene>
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        <name>KRT33A</name>
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          <protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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        <entity>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          <protein>
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          </protein>
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      <gene>
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        <name>LOC112446673</name>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>PKP4</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MJ11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT74</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A3KN27</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ELA2A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7YWU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N608</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI65</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNZ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT15</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRT6B</name>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QVY0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LIPN</name>
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              <externalid>G3MVZ9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TGM1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DSC3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>LIPJ</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BNT1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DSP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>DSC2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>LIPM</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10395190</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>KRT3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>KRT1</name>
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              <externalid>G3N0V2</externalid>
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          </protein>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BGD9</externalid>
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      <gene>
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      <gene>
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              <externalid>F1MKE7</externalid>
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      <gene>
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      <gene>
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    <smallmolecules>
      <smallmolecule>
        <externalid>1861780</externalid>
        <name>carboxylic acid</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
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        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>428258</externalid>
        <name>ceramide</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydron</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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      <linkedsystem>
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    </linkedsystems>
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  <biosystem>
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    <name>Transcriptional regulation of granulopoiesis</name>
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        <name>all-trans-retinoic acid</name>
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    </smallmolecules>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
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  <biosystem>
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    <name>MITF-M-regulated melanocyte development</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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      <gene>
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        <name>TCF7L2</name>
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              <externalid>A0A3Q1MAN6</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A452DIE9</externalid>
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          </protein>
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      <gene>
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              <externalid>F1N6W0</externalid>
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      <gene>
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              <externalid>P46196</externalid>
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      <gene>
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        <name>CTNNB1</name>
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          <protein>
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              <externalid>Q0VCX4</externalid>
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      <gene>
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        <name>KITLG</name>
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              <externalid>Q28132</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MITF</name>
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              <externalid>A0A3Q1MKP6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>AKT3</name>
        <entity>
          <protein>
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              <externalid>F1MYJ4</externalid>
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      <gene>
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        <name>TCF7L1</name>
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              <externalid>F1MJS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341989</externalid>
        <name>SIRT1</name>
        <entity>
          <protein>
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              <externalid>F1MQB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAB27A</name>
        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330705</externalid>
        <name>LEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418047</externalid>
        <name>MLPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIT</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EP300</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>QARS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2I</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RARS1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7YW98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SCYE1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PWM7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DARS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXT8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC15</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406083</externalid>
        <name>CSF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGS9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AIMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II26</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330709</externalid>
        <name>TCF7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG64</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416497</externalid>
        <name>EPRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>WNT3A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW2</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9859422</externalid>
        <name>P(1),P(4)-bis(5'-adenosyl) tetraphosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-HSA-9730414</externalid>
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      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
        <linkedsystemtype>
          <superset />
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    </linkedsystems>
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  <biosystem>
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    <name>Transcriptional and post-translational regulation of MITF-M expression and activity</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9856649</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>AKT3</name>
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          <protein>
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              <externalid>F1MYJ4</externalid>
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          </protein>
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      <gene>
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        <name>LARS1</name>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>A0A3Q1M881</externalid>
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          </protein>
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      <gene>
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        <name>SIRT1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MQB8</externalid>
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          </protein>
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      <gene>
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        <name>EEF1E1</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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      <gene>
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        <name>MAPK3</name>
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              <externalid>E1B8P9</externalid>
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      <gene>
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        <name>RPS6KA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IARS</name>
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      <gene>
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          <protein>
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              <externalid>F1MD32</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>UBE2I</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MARK3</name>
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          </protein>
        </entity>
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      <gene>
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        <name>MARS1</name>
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          <protein>
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              <externalid>A0A3Q1LLF2</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A452DIE9</externalid>
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          </protein>
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      <gene>
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        <name>RARS1</name>
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          <protein>
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              <externalid>A7YW98</externalid>
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          </protein>
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      <gene>
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        <name>SOX10</name>
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          <protein>
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              <externalid>F1N6W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SCYE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PWM7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DARS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXT8</externalid>
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          </protein>
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      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
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              <externalid>P46196</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347413</externalid>
        <entity>
          <protein>
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              <externalid>A0A3Q1M137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416440</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AIMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332406</externalid>
        <name>KITLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370794</externalid>
        <name>MITF</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MKP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330613</externalid>
        <name>WNT3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9859422</externalid>
        <name>P(1),P(4)-bis(5'-adenosyl) tetraphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58141</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9856649</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9730414</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9856651</externalid>
    <name>MITF-M-dependent gene expression</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9856651</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10418051</externalid>
        <name>MYRIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364110</externalid>
        <name>MYO5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409908</externalid>
        <name>USF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6XBT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416444</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330713</externalid>
        <name>TCF7L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392686</externalid>
        <name>RAB27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330705</externalid>
        <name>LEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416440</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418047</externalid>
        <name>MLPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416436</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330709</externalid>
        <name>TCF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370794</externalid>
        <name>MITF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9824585</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9825892</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9824594</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9856651</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9730414</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9824585</externalid>
    <name>Regulation of MITF-M-dependent genes involved in pigmentation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9824585</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10418051</externalid>
        <name>MYRIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364110</externalid>
        <name>MYO5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409908</externalid>
        <name>USF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6XBT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418047</externalid>
        <name>MLPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392686</externalid>
        <name>RAB27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9824585</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9856651</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9825892</externalid>
    <name>Regulation of MITF-M-dependent genes involved in cell cycle and proliferation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9825892</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10416444</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416440</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330713</externalid>
        <name>TCF7L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416436</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330709</externalid>
        <name>TCF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330705</externalid>
        <name>LEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9856651</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9824594</externalid>
    <name>Regulation of MITF-M-dependent genes involved in apoptosis</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9824594</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10416444</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416440</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416436</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370794</externalid>
        <name>MITF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9856651</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9843745</externalid>
    <name>Adipogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9843745</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327601</externalid>
        <name>RXRA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335902</externalid>
        <name>PPARG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18971</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-381340</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9843745</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1266738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381340</externalid>
    <name>Transcriptional regulation of white adipocyte differentiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381340</url>
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        </entity>
      </gene>
      <gene>
        <externalid>10362853</externalid>
        <name>LOXL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H737</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357983</externalid>
        <name>CTSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355650</externalid>
        <name>COL8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E303</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359060</externalid>
        <name>COL14A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333677</externalid>
        <name>TNC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361349</externalid>
        <name>PLOD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MET0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356169</externalid>
        <name>LOC112441463</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9645298</externalid>
        <name>COL16A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365677</externalid>
        <name>EMILIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373559</externalid>
        <name>NID1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398345</externalid>
        <name>CAPN13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339381</externalid>
        <name>DMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1N1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338476</externalid>
        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316649</externalid>
        <name>CTSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361801</externalid>
        <name>TLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329638</externalid>
        <name>ICAM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388025</externalid>
        <name>PHYKPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361232</externalid>
        <name>LEPREL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320351</externalid>
        <name>COL1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02465</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367358</externalid>
        <name>DDR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405120</externalid>
        <name>SCUBE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925998</externalid>
        <name>erythro-5-phosphonatoooxy-L-lysinium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760912</externalid>
        <name>L-allysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58321</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31611</externalid>
        <name>bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29488</externalid>
        <name>L-ascorbic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29073</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1474290</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1566977</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1566948</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3000171</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3000178</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474228</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-216083</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1474244</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1474290</externalid>
    <name>Collagen formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1474290</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359056</externalid>
        <name>COL13A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RND5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362861</externalid>
        <name>LOXL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K200</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361240</externalid>
        <name>P3H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359079</externalid>
        <name>COL21A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359083</externalid>
        <name>COL23A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361236</externalid>
        <name>CRTAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362857</externalid>
        <name>LOXL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355876</externalid>
        <name>COL11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362828</externalid>
        <name>SERPINH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361337</externalid>
        <name>PLOD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356537</externalid>
        <name>COL27A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M646</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338379</externalid>
        <name>COL6A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338317</externalid>
        <name>COL6A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361814</externalid>
        <name>PCOLCE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355764</externalid>
        <name>COL10A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338412</externalid>
        <name>COL6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368747</externalid>
        <name>PXDN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359087</externalid>
        <name>COL26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338311</externalid>
        <name>COL4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7SIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355821</externalid>
        <name>COL11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338542</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357934</externalid>
        <name>COL18A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359075</externalid>
        <name>COL20A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N021</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362849</externalid>
        <name>LOXL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333841</externalid>
        <name>BMP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361788</externalid>
        <name>ADAMTS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOXL2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COL14A1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>COL8A1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>COL6A5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COL5A3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ADAMTS2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PLOD3</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>PPIB</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <externalid>29488</externalid>
        <name>L-ascorbic acid</name>
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      <smallmolecule>
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        <name>dioxygen</name>
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      <smallmolecule>
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        <name>hydrogen peroxide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
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      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
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          <externalid>16526</externalid>
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      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>31611</externalid>
        <name>bromide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15858</externalid>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-1650814</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2022090</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1474290</externalid>
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      <linkedsystem>
        <externalid>R-BTA-1474244</externalid>
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    <externalid>R-BTA-1650814</externalid>
    <name>Collagen biosynthesis and modifying enzymes</name>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1650814</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>A4FUY3</externalid>
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              <externalid>F1MSJ7</externalid>
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        <name>CRTAP</name>
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              <externalid>E1BJ75</externalid>
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      <gene>
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      <gene>
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              <externalid>F1MZ30</externalid>
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      <gene>
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      <gene>
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              <externalid>E1BFV4</externalid>
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      <gene>
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        <name>COL14A1</name>
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              <externalid>E1BA17</externalid>
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      <gene>
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        <name>COL8A1</name>
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              <externalid>A7E303</externalid>
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      <gene>
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              <externalid>A0A3Q1M0N0</externalid>
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      <gene>
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        <name>COL4A6</name>
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      <gene>
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        <name>COL6A5</name>
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              <externalid>A0A3Q1LXW3</externalid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9793074</externalid>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-1474290</externalid>
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  </biosystem>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333703</externalid>
        <name>VTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367600</externalid>
        <name>GDF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367592</externalid>
        <name>BMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330266</externalid>
        <name>BMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ELN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>93433</externalid>
        <name>ITGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27977</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333713</externalid>
        <name>ITGB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EMILIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FBN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FBN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P98133</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324532</externalid>
        <name>TGFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP4</name>
        <entity>
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          </protein>
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      </gene>
      <gene>
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        <name>FBLN5</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MFAP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF86</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT97</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ITGB5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB9</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>EMILIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOXL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>copper(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2129379</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474244</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <taxnode>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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        <name>EFEMP2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG2</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>VTN</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBS7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>GDF5</name>
        <entity>
          <protein>
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              <externalid>F1MT44</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>BMP7</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>ITGAV</name>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>ELN</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>TGFB3</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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          </protein>
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          <protein>
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              <externalid>F1MTZ4</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>P98133</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>TGFB2</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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          <protein>
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              <externalid>Q2KJ89</externalid>
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          </protein>
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      <gene>
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        <name>ITGB1</name>
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          <protein>
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              <externalid>A0A140T8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MFAP5</name>
        <entity>
          <protein>
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              <externalid>A0A140T828</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP2</name>
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          <protein>
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              <externalid>F1MF86</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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              <externalid>A0A3Q1MT97</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ITGB5</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EMILIN2</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MFAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EMILIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2E4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BMP4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJH1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367382</externalid>
        <name>LTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N444</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2129379</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1566948</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Non-integrin membrane-ECM interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3000171</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10324463</externalid>
        <name>TGFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N449</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339370</externalid>
        <name>ACTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC07</externalid>
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          </protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338511</externalid>
        <name>COL5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357875</externalid>
        <name>MMP19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404813</externalid>
        <name>OPTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58874</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373445</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86341</externalid>
        <name>COL2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356185</externalid>
        <name>MMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394212</externalid>
        <name>CAPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356189</externalid>
        <name>MMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359052</externalid>
        <name>COL12A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N401</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357979</externalid>
        <name>CTSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398384</externalid>
        <name>CAST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MZC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357879</externalid>
        <name>CTSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25326</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356047</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M970</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400046</externalid>
        <name>HTRA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405120</externalid>
        <name>SCUBE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321742</externalid>
        <name>KLKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925998</externalid>
        <name>erythro-5-phosphonatoooxy-L-lysinium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760912</externalid>
        <name>L-allysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58321</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1592389</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1442490</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1474228</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474244</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1592389</externalid>
    <name>Activation of Matrix Metalloproteinases</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1592389</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356177</externalid>
        <name>MMP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356469</externalid>
        <name>MMP14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357983</externalid>
        <name>CTSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357967</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N430</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357858</externalid>
        <name>ELA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358172</externalid>
        <name>MMP16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N797</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358184</externalid>
        <name>MMP24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356169</externalid>
        <name>LOC112441463</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358188</externalid>
        <name>MMP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1F5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344606</externalid>
        <name>LOC509956</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357514</externalid>
        <name>MMP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358176</externalid>
        <name>MMP15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357954</externalid>
        <name>TPSB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356193</externalid>
        <name>MMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358180</externalid>
        <name>MMP17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356460</externalid>
        <name>PRSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321910</externalid>
        <name>PLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355465</externalid>
        <name>MMP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52176</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356181</externalid>
        <name>MMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358061</externalid>
        <name>KLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H320</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345830</externalid>
        <name>LOC112442231</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357998</externalid>
        <name>CTRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357934</externalid>
        <name>COL18A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356185</externalid>
        <name>MMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355461</externalid>
        <name>LOC100139881</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356189</externalid>
        <name>MMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357979</externalid>
        <name>CTSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321742</externalid>
        <name>KLKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1592389</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474228</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1442490</externalid>
    <name>Collagen degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1442490</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356177</externalid>
        <name>MMP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359056</externalid>
        <name>COL13A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RND5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356469</externalid>
        <name>MMP14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355650</externalid>
        <name>COL8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E303</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359064</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359788</externalid>
        <name>CTSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07688</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356104</externalid>
        <name>COL4A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338348</externalid>
        <name>COL6A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338577</externalid>
        <name>COL5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355876</externalid>
        <name>COL11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338443</externalid>
        <name>COL6A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356169</externalid>
        <name>LOC112441463</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357514</externalid>
        <name>MMP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356193</externalid>
        <name>MMP8</name>
        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>MMP20</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MMP15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHG1</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CTSD</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322775</externalid>
        <name>NDUFB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02367</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313553</externalid>
        <name>AADAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325647</externalid>
        <name>GSTT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313484</externalid>
        <name>HIBADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737143</externalid>
        <name>dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736388</externalid>
        <name>N-carbamoyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024562</externalid>
        <name>aspirin-triggered resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914021</externalid>
        <name>(R)-4,8-dimethylnonanoylcarnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640384</externalid>
        <name>5-ammoniolevulinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>356416</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30341</externalid>
        <name>methylglyoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17158</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929651</externalid>
        <name>L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605734</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693660</externalid>
        <name>ecgonine benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29516</externalid>
        <name>polysulfur</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17909</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854367</externalid>
        <name>(dioxido)oxidocarbonate(.1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609725</externalid>
        <name>Type 2 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140918</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694562</externalid>
        <name>acyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22221</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317106</externalid>
        <name>L-pipecolic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61185</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31615</externalid>
        <name>hydrogen chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114814</externalid>
        <name>D-erythrose 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917121</externalid>
        <name>2-methylacetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737454</externalid>
        <name>dUTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61555</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760860</externalid>
        <name>D-ribulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58121</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395393</externalid>
        <name>4-acetamidosalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879994</externalid>
        <name>4-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114851</externalid>
        <name>guanidinoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31143</externalid>
        <name>N-acetyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760792</externalid>
        <name>N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6811611</externalid>
        <name>pristanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916398</externalid>
        <name>17(R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736389</externalid>
        <name>(S)-dihydroorotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31725</externalid>
        <name>cocaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874449</externalid>
        <name>glycerophosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786182</externalid>
        <name>Olmesartan medoxomil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760812</externalid>
        <name>3-sulfino-L-alanine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925991</externalid>
        <name>L-saccharopinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57951</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913882</externalid>
        <name>2-oxohexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327960</externalid>
        <name>5,10-methylenetetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60473</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024476</externalid>
        <name>7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138602</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845603</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNac-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87787</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40425</externalid>
        <name>omeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7772</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930611</externalid>
        <name>1,4-benzoquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6800152</externalid>
        <name>dimethylarsinic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48765</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090074</externalid>
        <name>alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395385</externalid>
        <name>sulfacetamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018639</externalid>
        <name>calcitroic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317324</externalid>
        <name>itaconate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737732</externalid>
        <name>nucleoside 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31383</externalid>
        <name>5alpha-cholest-7-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024856</externalid>
        <name>resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865932</externalid>
        <name>O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945788</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395905</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65131</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090048</externalid>
        <name>beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63808</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737144</externalid>
        <name>dUDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065205</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4,6S2-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63515</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915837</externalid>
        <name>12(S)-HHTrE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966603</externalid>
        <name>1D-myo-inositol 3,4-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065234</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63511</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865933</externalid>
        <name>(R)-3-hydroxyacyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734625</externalid>
        <name>SAICAR(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692439</externalid>
        <name>4-hydroperoxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>196991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796683</externalid>
        <name>L-cysteinylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8932800</externalid>
        <name>meadowlactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930607</externalid>
        <name>hydroquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943294</externalid>
        <name>doxorubicinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498742</externalid>
        <name>2-acyl-sn-glycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31683</externalid>
        <name>diiodine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915975</externalid>
        <name>(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34835</externalid>
        <name>resveratrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913884</externalid>
        <name>formyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166601</externalid>
        <name>trans-dec-3-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316198</externalid>
        <name>D-pantetheine 4'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841183</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925932</externalid>
        <name>5-formimidoyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490353</externalid>
        <name>aflatoxin M1 8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629752</externalid>
        <name>5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865943</externalid>
        <name>O-[S-(3R)-3-hydroxyacylpantetheine-4'-phosphoryl]serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760864</externalid>
        <name>6-phosphonatooxy-D-gluconate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490358</externalid>
        <name>Aflatoxin B1 exo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024580</externalid>
        <name>aspirin-triggered resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045968</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29650</externalid>
        <name>4-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395394</externalid>
        <name>desmethyl loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915870</externalid>
        <name>20-oxoleukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317372</externalid>
        <name>quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36141</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>77356</externalid>
        <name>3-oxo-fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15489</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065227</externalid>
        <name>beta-D-GalNAc4S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63519</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573400</externalid>
        <name>4-fumarylacetoacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843874</externalid>
        <name>phytosphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760862</externalid>
        <name>(R)-5-phosphonatomevalonate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843243</externalid>
        <name>N-hexadecanoylsphinganine-1-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9794601</externalid>
        <name>N(6),N(6),N(6)-trimethyl-L-lysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58100</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929650</externalid>
        <name>3-hydroxyanthranilate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36559</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37249</externalid>
        <name>menadione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913867</externalid>
        <name>phytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57391</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498727</externalid>
        <name>1-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731597</externalid>
        <name>O(6)-methyl-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30939</externalid>
        <name>5,6-dihydrothymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27468</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930578</externalid>
        <name>L-adenosylselenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022662</externalid>
        <name>resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32647</externalid>
        <name>linoleoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760977</externalid>
        <name>lithocholate sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929647</externalid>
        <name>3-hydroxy-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966611</externalid>
        <name>1D-myo-inositol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58401</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760852</externalid>
        <name>creatine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840473</externalid>
        <name>1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915891</externalid>
        <name>12(R)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327966</externalid>
        <name>4-hydroxydebrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63800</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163917</externalid>
        <name>zymosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316350</externalid>
        <name>S-(hydroxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024488</externalid>
        <name>4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911702</externalid>
        <name>(7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782158</externalid>
        <name>2-methylpentadecenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945113</externalid>
        <name>presqualene diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737598</externalid>
        <name>uridine 2'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845542</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316197</externalid>
        <name>1,2-dihydroxy-5-(methylthio)pent-1-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915967</externalid>
        <name>(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025146</externalid>
        <name>10(S),17(S)-dihydroxy-omega 6-docosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138674</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30018</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090062</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63811</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916747</externalid>
        <name>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137442</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661284</externalid>
        <name>L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945793</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176607</externalid>
        <name>26-hydroxycholesterol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917114</externalid>
        <name>(S)-3-hydroxyisobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62611</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30379</externalid>
        <name>4-aminobenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32673</externalid>
        <name>pseudouridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929635</externalid>
        <name>N-formyl-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025156</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640393</externalid>
        <name>preuroporphyrinogen(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916771</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966593</externalid>
        <name>D-glucopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024861</externalid>
        <name>4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30074</externalid>
        <name>ubiquinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916416</externalid>
        <name>17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694131</externalid>
        <name>Benzo[a]pyrene-cis-4,5-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065206</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63516</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760797</externalid>
        <name>1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316161</externalid>
        <name>3-methyl-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162216</externalid>
        <name>2-decaprenyl-6-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50774</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762301</externalid>
        <name>5,6-dihydroxyindole-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142798</externalid>
        <name>15-epi-lipoxin B4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35105</externalid>
        <name>(4-hydroxyphenyl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916384</externalid>
        <name>15-oxolipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78311</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023656</externalid>
        <name>(18R)-resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916382</externalid>
        <name>18(S)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132083</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916751</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960380</externalid>
        <name>folate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114834</externalid>
        <name>5,6-dihydrouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15901</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490343</externalid>
        <name>aflatoxin B1 dialdehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114836</externalid>
        <name>alpha-D-galactose 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673061</externalid>
        <name>N-oleoyl-L-phenylalaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762303</externalid>
        <name>NMNH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90832</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955516</externalid>
        <name>2''-O-glutaryl-ADP-D-ribose(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498776</externalid>
        <name>2-monolysocardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9838704</externalid>
        <name>alpha-L-Fucp-(1-&gt;4)-[beta-D-Galp-(1-&gt;3)]-beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-D-Glcp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327974</externalid>
        <name>4-hydroxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913889</externalid>
        <name>(2S)-pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930579</externalid>
        <name>L-selenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42365</externalid>
        <name>skatole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9171</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869375</externalid>
        <name>D-ribosylnicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966598</externalid>
        <name>1D-myo-inositol 1,2,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57798</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37145</externalid>
        <name>(3Z,6Z)-dodecadienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395906</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731299</externalid>
        <name>8-oxo-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166419</externalid>
        <name>N-hydroxy-4-aminobiphenyl O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32701</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162202</externalid>
        <name>3-decaprenyl-4,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760744</externalid>
        <name>isovaleryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736311</externalid>
        <name>5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137981</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114859</externalid>
        <name>pyridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841192</externalid>
        <name>steroid sulfate oxoanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966362</externalid>
        <name>1D-myo-inositol 3,4,6-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946136</externalid>
        <name>4,4-dimethyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760756</externalid>
        <name>carnosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760974</externalid>
        <name>tetracosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760923</externalid>
        <name>bis(beta-glucosyluronate)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>195686</externalid>
        <name>5alpha-cholesta-7,24-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861965</externalid>
        <name>glyoxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760976</externalid>
        <name>benzylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>225238</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30054</externalid>
        <name>xylitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17151</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42447</externalid>
        <name>17beta-estradiol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762308</externalid>
        <name>N,N-dimethylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114783</externalid>
        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15956</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490350</externalid>
        <name>Aflatoxin B1 exo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692441</externalid>
        <name>Carboxyphosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737587</externalid>
        <name>dITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327961</externalid>
        <name>4-hydroxy-17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874448</externalid>
        <name>1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114898</externalid>
        <name>(S)-1-pyrroline-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914140</externalid>
        <name>4-saturated-trans-3-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850553</externalid>
        <name>adenosine 5'-tetraphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176504</externalid>
        <name>2-acetamidofluorene N-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841156</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-L-Fuc-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40555</externalid>
        <name>paclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45863</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913887</externalid>
        <name>2-hydroxyphytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731627</externalid>
        <name>N(6)-methyl-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172872</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6813741</externalid>
        <name>1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58444</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694471</externalid>
        <name>lysophosphatidylcholine 14:0</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31337</externalid>
        <name>cholesta-5,7-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090071</externalid>
        <name>alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164166</externalid>
        <name>(S)-methylmalonate semialdehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62413</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316562</externalid>
        <name>glycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395901</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162114</externalid>
        <name>acetyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40574</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854364</externalid>
        <name>Fe3S4 iron-sulfur cluster</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31211</externalid>
        <name>(R)-3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966606</externalid>
        <name>1D-myo-inositol 1,4-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772507</externalid>
        <name>2-deoxy-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57259</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32683</externalid>
        <name>sedoheptulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842381</externalid>
        <name>(4E)-unsatiated ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914035</externalid>
        <name>3-oxopristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327670</externalid>
        <name>10-formyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28010</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31343</externalid>
        <name>pseudouridine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18116</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498745</externalid>
        <name>2-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731233</externalid>
        <name>8-oxo-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172871</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929693</externalid>
        <name>S-methyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782159</externalid>
        <name>2-methylpentadec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866402</externalid>
        <name>2'-deoxyribonucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73316</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629743</externalid>
        <name>3-diphospho-1D-myo-inositol 1,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34053</externalid>
        <name>thiamine(1+) triphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846338</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327680</externalid>
        <name>12-HETE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853726</externalid>
        <name>coproporphyrinogen III(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57309</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085431</externalid>
        <name>ferricytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914124</externalid>
        <name>S-acyl-4'-phosphopantetheine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861590</externalid>
        <name>2''-O-lipoyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916399</externalid>
        <name>(17S)-HDHA(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609696</externalid>
        <name>GlcNAc-beta1,3-Gal-R</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>389633</externalid>
        <name>pristanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844864</externalid>
        <name>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915917</externalid>
        <name>12(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760984</externalid>
        <name>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176612</externalid>
        <name>3,3',5-triiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843200</externalid>
        <name>(2R)-2-hydroxy fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31165</externalid>
        <name>(S)-2,3-epoxysqualene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736391</externalid>
        <name>orotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629757</externalid>
        <name>1-diphospho-1D-myo-inositol 3,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760898</externalid>
        <name>anserine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30311</externalid>
        <name>hydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609712</externalid>
        <name>Lewis Y antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762227</externalid>
        <name>1-palmitoylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58303</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316406</externalid>
        <name>arsenite(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>584170</externalid>
        <name>homogentisate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316163</externalid>
        <name>(R)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16004</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844852</externalid>
        <name>ganglioside GM2 (18:0) (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316542</externalid>
        <name>N-acylphytosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966589</externalid>
        <name>5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate(11-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162211</externalid>
        <name>4-hydroxy-3-all-trans-decaprenylbenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925787</externalid>
        <name>L-cysteate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58090</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045959</externalid>
        <name>(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024860</externalid>
        <name>7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29568</externalid>
        <name>pyrroloquinoline quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166605</externalid>
        <name>dopamine 3-O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916394</externalid>
        <name>(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090059</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63645</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114908</externalid>
        <name>sulfanilamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911735</externalid>
        <name>prostaglandin H3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916385</externalid>
        <name>lipoxin B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162197</externalid>
        <name>2-decaprenyl-6-methoxyhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845517</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32285</externalid>
        <name>desmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869369</externalid>
        <name>NMN(-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065262</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc6S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63512</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945782</externalid>
        <name>5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760906</externalid>
        <name>5-hydroxy-L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29794</externalid>
        <name>4-methyl-2-oxopentanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947574</externalid>
        <name>molybdopterin(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760851</externalid>
        <name>hypotaurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736308</externalid>
        <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837339</externalid>
        <name>3'-dephospho-CoA(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57328</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423724</externalid>
        <name>keto-phenylpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18005</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9758891</externalid>
        <name>corrinoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33913</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316215</externalid>
        <name>3-phosphonatooxypyruvate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938242</externalid>
        <name>(R)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64075</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844331</externalid>
        <name>sphinganine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317273</externalid>
        <name>sphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916383</externalid>
        <name>aspirin-triggered protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114913</externalid>
        <name>12-hydroxylauric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>39567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30193</externalid>
        <name>1H-indole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045962</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2104999</externalid>
        <name>beta-D-Galp6S-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63846</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840994</externalid>
        <name>choline phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>295975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914118</externalid>
        <name>hexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327678</externalid>
        <name>3-methyleneindolenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114846</externalid>
        <name>trimethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916001</externalid>
        <name>20-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760912</externalid>
        <name>L-allysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58321</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846303</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78569</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395898</externalid>
        <name>5-methyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933527</externalid>
        <name>2,3-bisphosphonato-D-glycerate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760814</externalid>
        <name>sphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57756</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731654</externalid>
        <name>methylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317429</externalid>
        <name>(S)-3-hydroxyisobutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914048</externalid>
        <name>O-propanoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024864</externalid>
        <name>4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39273</externalid>
        <name>lead(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27889</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854162</externalid>
        <name>ferroheme o(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947507</externalid>
        <name>precursor Z(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911738</externalid>
        <name>5-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865938</externalid>
        <name>(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490351</externalid>
        <name>aflatoxin B1 endo-8,9-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78586</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40945</externalid>
        <name>phenacetin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5688992</externalid>
        <name>4-ethoxyaniline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947519</externalid>
        <name>Mo(VI)(=O)(=S)(OH)-molybdopterin cofactor(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60102</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966599</externalid>
        <name>1D-myo-inositol 1,3-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731241</externalid>
        <name>2-hydroxy-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609726</externalid>
        <name>Type 1 disialyl-paragloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938240</externalid>
        <name>6-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34987</externalid>
        <name>dyspropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30809</externalid>
        <name>pantetheine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929454</externalid>
        <name>O-phosphonato-L-serine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142812</externalid>
        <name>5,6-DHET</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869380</externalid>
        <name>nicotinate D-ribonucleotide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090068</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63666</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737736</externalid>
        <name>3-ureidoisobutyrate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5228369</externalid>
        <name>alpha-Neu5NAc-(2-&gt;8)-alpha-Neu5NAc-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033789</externalid>
        <name>alpha-D-Gal-(1-&gt;3)-alpha-D-GlcNAc-(1-&gt;4)-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861970</externalid>
        <name>(R)-S-lactoylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696109</externalid>
        <name>alkylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30793</externalid>
        <name>hexadecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38865</externalid>
        <name>1,5-anhydro-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845590</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874441</externalid>
        <name>1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841154</externalid>
        <name>beta-D-GalpNAc-(1-&gt;4)-[alpha-Neup5Ac-(2-&gt;3)]-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736417</externalid>
        <name>N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911700</externalid>
        <name>(4Z,8E,10Z,13Z,16Z,19Z)-7-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914133</externalid>
        <name>trans,trans-2,4-dienoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30291</externalid>
        <name>hexadecanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490347</externalid>
        <name>Aflatoxin B1 endo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78578</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848505</externalid>
        <name>palmityl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760901</externalid>
        <name>7,8-dihydroneopterin 3'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114869</externalid>
        <name>4-maleylacetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760761</externalid>
        <name>glutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737733</externalid>
        <name>N-carbamoyl-beta-alaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11892</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661269</externalid>
        <name>3-dehydro-L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357682</externalid>
        <name>methylselenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64685</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737462</externalid>
        <name>P(1),P(6)-bis(5'-adenosyl)hexaphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929618</externalid>
        <name>2-iminobutanoic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30050</externalid>
        <name>steroid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045965</externalid>
        <name>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114852</externalid>
        <name>N-acetyl-L-glutamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760789</externalid>
        <name>methylarsonate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105009</externalid>
        <name>beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30331</externalid>
        <name>cob(II)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395217</externalid>
        <name>6-hydroxypaclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63859</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105002</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63850</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30739</externalid>
        <name>D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925938</externalid>
        <name>trans-urocanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17771</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36923</externalid>
        <name>4alpha-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760911</externalid>
        <name>coproporphyrinogen I(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925986</externalid>
        <name>1-piperideine-2-carboxylic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760749</externalid>
        <name>3-methylbut-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327983</externalid>
        <name>3-dehydro-4-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9968566</externalid>
        <name>(R)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936512</externalid>
        <name>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695948</externalid>
        <name>docosanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40379</externalid>
        <name>methylarsonous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17826</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930121</externalid>
        <name>S-sulfanylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840456</externalid>
        <name>1-oleoyl-2-palmitoleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938244</externalid>
        <name>2-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490348</externalid>
        <name>aflatoxin M1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36327</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760926</externalid>
        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395395</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9035290</externalid>
        <name>nitrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2046043</externalid>
        <name>(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63543</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731611</externalid>
        <name>N(6)-methyl-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693766</externalid>
        <name>Ac-Asp-Glu(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395215</externalid>
        <name>7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853722</externalid>
        <name>protoporphyrin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694070</externalid>
        <name>Benzo[a]pyrene-4,5-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5643846</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760787</externalid>
        <name>trioxidosulfanidosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853736</externalid>
        <name>uroporphyrinogen III(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57308</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033794</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696232</externalid>
        <name>dimethylarsinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40653</externalid>
        <name>phenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760855</externalid>
        <name>riboflavin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960802</externalid>
        <name>biocytin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929696</externalid>
        <name>L-cystathionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58161</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34543</externalid>
        <name>mono(glucosyluronic acid)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736398</externalid>
        <name>5-amino-1-(5-phosphonato-D-ribosyl)imidazolium-4-carboxylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498721</externalid>
        <name>1-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>428282</externalid>
        <name>trans-hexadec-2-enal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395863</externalid>
        <name>debrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34665</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840469</externalid>
        <name>PE(18:0/16:1(9Z)) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760975</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917130</externalid>
        <name>trans-3-methylglutaconyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842019</externalid>
        <name>(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29828</externalid>
        <name>pyridoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925933</externalid>
        <name>N-formimidoyl-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024565</externalid>
        <name>7S,8S-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760753</externalid>
        <name>S-adenosylmethioninaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327984</externalid>
        <name>4-methylpentan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916381</externalid>
        <name>(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843245</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34415</externalid>
        <name>triphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915969</externalid>
        <name>(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760983</externalid>
        <name>cholesterol sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731243</externalid>
        <name>8-oxo-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024571</externalid>
        <name>aspirin-triggered resolvin D1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024587</externalid>
        <name>4S(5)-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31019</externalid>
        <name>beta-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874445</externalid>
        <name>glycerophosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423440</externalid>
        <name>beta-ionone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916411</externalid>
        <name>18(R)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640392</externalid>
        <name>porphobilinogen(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925788</externalid>
        <name>2-oxoglutaramate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760848</externalid>
        <name>CDP-ethanolamine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629742</externalid>
        <name>5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34859</externalid>
        <name>all-cis-icosa-8,11,14-trienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760793</externalid>
        <name>(R)-4'-phosphonatopantothenate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866398</externalid>
        <name>nucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1660672</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731303</externalid>
        <name>8-oxo-dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929219</externalid>
        <name>(6R)-L-erythro-6,7-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917117</externalid>
        <name>methacrylyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36927</externalid>
        <name>7-dehydrodesmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429777</externalid>
        <name>sphingomyelin d18:1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316548</externalid>
        <name>D-glycerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762300</externalid>
        <name>(4Z,7Z,10Z,14E,16Z,19Z)-13-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930571</externalid>
        <name>L-selenocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29698</externalid>
        <name>aldehydo-D-xylose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734629</externalid>
        <name>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845499</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933513</externalid>
        <name>alpha-D-glucose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916392</externalid>
        <name>5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966601</externalid>
        <name>1D-myo-inositol 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31045</externalid>
        <name>N-acetylserotonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674776</externalid>
        <name>2-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916409</externalid>
        <name>protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911128</externalid>
        <name>dimethylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866580</externalid>
        <name>2'-deoxyribonucleoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914033</externalid>
        <name>4,8,12-trimethyltridecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31239</externalid>
        <name>trimethylamine N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023704</externalid>
        <name>5S(6)-epoxy-18(R)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784965</externalid>
        <name>valacyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327669</externalid>
        <name>19-hydroxyprostaglandin H2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162217</externalid>
        <name>3-decaprenyl-4-hydroxy-5-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327673</externalid>
        <name>1-hexadecyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022663</externalid>
        <name>5(S)6-epoxy-18(S)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166420</externalid>
        <name>N-acetoxy-1,1'-biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939575</externalid>
        <name>(R)-indole-3-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916396</externalid>
        <name>22-hydroxyprotectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674785</externalid>
        <name>3-phosphonato-D-glyceroyl phosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29936</externalid>
        <name>D-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937158</externalid>
        <name>sulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30391</externalid>
        <name>betaine aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15710</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760980</externalid>
        <name>1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916421</externalid>
        <name>resolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132079</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929683</externalid>
        <name>4-(2-aminophenyl)-2,4-dioxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58147</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33435</externalid>
        <name>taurolithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609718</externalid>
        <name>disialyl-Lewis A antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34065</externalid>
        <name>gamma-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15508</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164584</externalid>
        <name>1-acylglycerophosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866618</externalid>
        <name>2'-deoxyribonucleoside 5'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6793344</externalid>
        <name>benzo[a]pyrene-7,8-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87752</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942549</externalid>
        <name>indole-5,6-quinone-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>177869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840463</externalid>
        <name>PE(16:1(9Z)/16:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024897</externalid>
        <name>(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138653</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737734</externalid>
        <name>(R)-3-aminoisobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423740</externalid>
        <name>all-trans-decaprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914018</externalid>
        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065221</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925950</externalid>
        <name>3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77893</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327668</externalid>
        <name>3-hydroxypristanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045963</externalid>
        <name>alpha-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>51985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929929</externalid>
        <name>L-lanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693979</externalid>
        <name>N(6)-dihydrolipoyl-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917132</externalid>
        <name>2-methylcrotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57337</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840849</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395209</externalid>
        <name>5,10-methenyltetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65049</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090034</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63807</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29930</externalid>
        <name>CDP-choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36929</externalid>
        <name>14-demethyllanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865947</externalid>
        <name>trans-2-octadecenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861588</externalid>
        <name>S-(alpha-chlorocarboxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>229639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737138</externalid>
        <name>dCDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945806</externalid>
        <name>3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5618013</externalid>
        <name>aflatoxin B1 triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861840</externalid>
        <name>beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693964</externalid>
        <name>N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760754</externalid>
        <name>(N(omega)-L-arginino)succinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57472</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737599</externalid>
        <name>3'-UMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762228</externalid>
        <name>3,5-diiodo-L-tyrosinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57506</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760985</externalid>
        <name>3-oxohexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73980</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971091</externalid>
        <name>O-lauroyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77086</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40429</externalid>
        <name>1,5-anhydro-D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736397</externalid>
        <name>5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945104</externalid>
        <name>4beta-methylzymosterol-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915976</externalid>
        <name>16-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731297</externalid>
        <name>8-oxo-GMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>145694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29788</externalid>
        <name>3,4-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840447</externalid>
        <name>PE(16:1(9Z)/14:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317514</externalid>
        <name>(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490352</externalid>
        <name>Aflatoxin B1 exo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736309</externalid>
        <name>2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9036985</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29940</externalid>
        <name>L-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17399</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31423</externalid>
        <name>(R)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15465</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695975</externalid>
        <name>2,3-dehydrobehenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736314</externalid>
        <name>5-phospho-beta-D-ribosylaminium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58681</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30565</externalid>
        <name>(S)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216566</externalid>
        <name>indolin-2-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39963</externalid>
        <name>loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6532</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114872</externalid>
        <name>4-trimethylammoniobutanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498723</externalid>
        <name>2-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327978</externalid>
        <name>5'-hydroxyomeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63840</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929690</externalid>
        <name>cis,cis-2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33265</externalid>
        <name>(R,R,R)-alpha-tocopherol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024581</externalid>
        <name>aspirin-triggered resolvin D2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395390</externalid>
        <name>methimazole S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045960</externalid>
        <name>(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911706</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140260</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915898</externalid>
        <name>hepoxilin B3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878652</externalid>
        <name>1-myristoyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845501</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945090</externalid>
        <name>presqualene monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237170</externalid>
        <name>S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114953</externalid>
        <name>keto-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916405</externalid>
        <name>17-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654570</externalid>
        <name>quinolinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161607</externalid>
        <name>malonaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>566274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498720</externalid>
        <name>2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841158</externalid>
        <name>alpha-Neup5Ac-(2-&gt;3)-beta-D-Galp-(1-&gt;4)-[alpha-L-Fucp-(1-&gt;3)]-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61711</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731301</externalid>
        <name>8-oxo-GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5250592</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090027</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63809</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844857</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846339</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023697</externalid>
        <name>(5Z,8Z,11Z,14Z,16E,18R)-18-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914041</externalid>
        <name>4,8-dimethylnonanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9037617</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498741</externalid>
        <name>1-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317402</externalid>
        <name>(S)-3-methyl-2-oxovalerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939574</externalid>
        <name>3-(1H-indol-3-yl)propanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915863</externalid>
        <name>20-hydroxy-20-oxoleukotriene B4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29944</externalid>
        <name>pyridoxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16709</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695956</externalid>
        <name>p-nitrophenyl butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85867</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929922</externalid>
        <name>L-homolanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865436</externalid>
        <name>copper cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30052</externalid>
        <name>thiamine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30511</externalid>
        <name>pyridoxamine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33333</externalid>
        <name>4-aminosalicylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840845</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;3)-alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917133</externalid>
        <name>(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57312</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760918</externalid>
        <name>5'-adenylyl sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58243</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859158</externalid>
        <name>isobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760924</externalid>
        <name>L-gamma-glutamyl-L-cysteinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34775</externalid>
        <name>tetrahydrofolyl-poly(glutamic acid) macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39679</externalid>
        <name>cyclophosphamide hydrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36961</externalid>
        <name>imidazole-4-acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629758</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913892</externalid>
        <name>2-hydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759439</externalid>
        <name>S-substituted glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90779</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33751</externalid>
        <name>cyanocob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48225</externalid>
        <name>8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737142</externalid>
        <name>dTDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9020465</externalid>
        <name>(18S)-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731607</externalid>
        <name>O(6)-methyl-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065211</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114887</externalid>
        <name>purine-6-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969925</externalid>
        <name>4-pyridoxate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915899</externalid>
        <name>5-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40933</externalid>
        <name>N'-acetylisoniazid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7207</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9866133</externalid>
        <name>ferroheme c(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61717</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8865641</externalid>
        <name>lysophosphatidylcholine 22:6</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37509</externalid>
        <name>5,6-dihydroxyindole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176578</externalid>
        <name>3,3'-diiodothyronine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327985</externalid>
        <name>4-hydroxyphenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327675</externalid>
        <name>3-hydroxy-4-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915650</externalid>
        <name>11-epi-prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33991</externalid>
        <name>O-palmitoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395386</externalid>
        <name>tamoxifen N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317270</externalid>
        <name>sphingoid 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946143</externalid>
        <name>4,4-dimethyl-8,14-cholestadien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176561</externalid>
        <name>4-nitrophenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045964</externalid>
        <name>(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938248</externalid>
        <name>(S)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30227</externalid>
        <name>tyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316849</externalid>
        <name>(S)-1-piperideine-6-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911731</externalid>
        <name>(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37143</externalid>
        <name>(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38065</externalid>
        <name>erythro-4-hydroxy-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395396</externalid>
        <name>pregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1497812</externalid>
        <name>monodehydro-L-ascorbate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731232</externalid>
        <name>2-oxo-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916404</externalid>
        <name>resolvin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914043</externalid>
        <name>(E)-2,3-didehydropristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975651</externalid>
        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609711</externalid>
        <name>Lewis X antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914122</externalid>
        <name>cis-3-octenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942548</externalid>
        <name>L-dopachromate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33327</externalid>
        <name>3-iodo-L-tyrosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841796</externalid>
        <name>3-dehydrosphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760972</externalid>
        <name>3-oxooctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844848</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395389</externalid>
        <name>17alpha-hydroxypregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731242</externalid>
        <name>2-oxo-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865940</externalid>
        <name>3-hydroxyoctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694576</externalid>
        <name>mycophenolic acid O-acyl-glucuronide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024866</externalid>
        <name>resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925918</externalid>
        <name>sedoheptulose 7-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947564</externalid>
        <name>molybdate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105014</externalid>
        <name>beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490359</externalid>
        <name>Aflatoxin B1 endo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36931</externalid>
        <name>24,25-dihydrolanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29584</externalid>
        <name>D-ribofuranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47013</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317283</externalid>
        <name>(S)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760978</externalid>
        <name>S-(2,4-dinitrophenyl)glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842386</externalid>
        <name>phytoceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>183157</externalid>
        <name>5-acetamido-6-formamido-3-methyluracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760908</externalid>
        <name>5-diphospho-1D-myo-inositol pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696452</externalid>
        <name>(R)-3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166608</externalid>
        <name>S-(2-hydroxyethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760920</externalid>
        <name>uroporphyrinogen I(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861826</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841155</externalid>
        <name>alpha-L-Fucp-(1-&gt;2)-beta-D-Galp-(1-&gt;3)-[alpha-L-Fucp-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760863</externalid>
        <name>L-2-aminoadipate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58672</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176506</externalid>
        <name>pregnenolone sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760979</externalid>
        <name>3-oxodocosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749390</externalid>
        <name>2'-deoxyuridine 3'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9794619</externalid>
        <name>(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>141499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925998</externalid>
        <name>erythro-5-phosphonatoooxy-L-lysinium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490346</externalid>
        <name>Aflatoxin B1 endo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48605</externalid>
        <name>hydrogensulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090022</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853737</externalid>
        <name>protoporphyrinogen(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114930</externalid>
        <name>umbelliferone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27510</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216637</externalid>
        <name>3-hydroxypalmitic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176589</externalid>
        <name>3,3'-diiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786178</externalid>
        <name>diketone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29848</externalid>
        <name>benzaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9832973</externalid>
        <name>beta-D-fructofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189459</externalid>
        <name>dipyrromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841240</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930117</externalid>
        <name>3-mercaptopyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57678</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114875</externalid>
        <name>4-(trimethylammonio)butanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16244</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760745</externalid>
        <name>(6R)-5,10-methenyltetrahydrofolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327986</externalid>
        <name>4-hydroxytolbutamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327677</externalid>
        <name>(24S)-1alpha,24,25-trihydroxyvitamin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8934415</externalid>
        <name>1-monomyristoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9858329</externalid>
        <name>2-oxoadipate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942552</externalid>
        <name>L-dopaquinone zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737145</externalid>
        <name>dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162199</externalid>
        <name>3-demethylubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64182</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9038578</externalid>
        <name>(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140196</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395397</externalid>
        <name>4-acetamidobenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357689</externalid>
        <name>methylselenenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696217</externalid>
        <name>methylarsonite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33603</externalid>
        <name>N-methylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966612</externalid>
        <name>1D-myo-inositol 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114848</externalid>
        <name>D-glyceraldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762309</externalid>
        <name>sarcosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045961</externalid>
        <name>(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317274</externalid>
        <name>(R)-mevalonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692223</externalid>
        <name>benzo[a]pyrene-cis-7,8-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30875</externalid>
        <name>4-nitrophenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605616</externalid>
        <name>N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142720</externalid>
        <name>6-epi-lipoxin A4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490356</externalid>
        <name>aflatoxin Q1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609723</externalid>
        <name>Type 1 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237127</externalid>
        <name>4-methylthio-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114902</externalid>
        <name>ethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760845</externalid>
        <name>N-phosphocreatinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327681</externalid>
        <name>3,16-dihydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945824</externalid>
        <name>3beta-hydroxy-4beta-methyl-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490357</externalid>
        <name>Aflatoxin B1 exo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166589</externalid>
        <name>cis-dec-4-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930580</externalid>
        <name>selanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29317</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845579</externalid>
        <name>ganglioside GD3(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915885</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731224</externalid>
        <name>2-hydroxy-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784232</externalid>
        <name>4-hydroxy-2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17742</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30319</externalid>
        <name>pyridoxamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162196</externalid>
        <name>2-decaprenyl-6-methoxy-3-methylhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760741</externalid>
        <name>icosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57380</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936450</externalid>
        <name>Mo-molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841056</externalid>
        <name>sphingomyelin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915995</externalid>
        <name>17-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760413</externalid>
        <name>mycophenolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915909</externalid>
        <name>12-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945112</externalid>
        <name>4alpha-carboxyzymosterol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731225</externalid>
        <name>8-oxo-dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166604</externalid>
        <name>(2E,4Z)-deca-2,4-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916380</externalid>
        <name>8-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490349</externalid>
        <name>Aflatoxin B1 endo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930123</externalid>
        <name>disulfanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878986</externalid>
        <name>deamido-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914137</externalid>
        <name>(R)-3-hydroxyhexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316798</externalid>
        <name>8-oxo-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945089</externalid>
        <name>prenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694585</externalid>
        <name>N-arachidonoylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945105</externalid>
        <name>geranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843244</externalid>
        <name>N-hexadecanoylsphinganine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859161</externalid>
        <name>(R)-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>156439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39913</externalid>
        <name>isoniazide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6030</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843204</externalid>
        <name>2-saturated fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30477</externalid>
        <name>pyridoxine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914135</externalid>
        <name>trans-2-hexacosenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105023</externalid>
        <name>beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925990</externalid>
        <name>erythro-5-hydroxy-L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58357</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936428</externalid>
        <name>N(omega)-hydroxyarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085422</externalid>
        <name>ferrocytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916402</externalid>
        <name>18-oxoresolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176590</externalid>
        <name>N-hydroxy-2-acetamidofluorene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760847</externalid>
        <name>L-glutamic 5-semialdehyde zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737591</externalid>
        <name>2'-deoxyinosine 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237131</externalid>
        <name>5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737590</externalid>
        <name>XTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762310</externalid>
        <name>stearoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57394</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142681</externalid>
        <name>eoxin C4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63984</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090046</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840626</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760916</externalid>
        <name>pyridoxal 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>597326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915895</externalid>
        <name>eoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166417</externalid>
        <name>benzo[a]pyrene diol epoxide I</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694561</externalid>
        <name>N-acylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166587</externalid>
        <name>phenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237088</externalid>
        <name>S-methyl-5-thio-D-ribulose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9856696</externalid>
        <name>(S)-4-hydroxymandelate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736393</externalid>
        <name>orotidine 5'-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57538</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395904</externalid>
        <name>(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842378</externalid>
        <name>dihydroceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163084</externalid>
        <name>1-chloro-2,4-dinitrobenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34718</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796682</externalid>
        <name>5-oxo-L-prolinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865942</externalid>
        <name>2,3-trans-enoyl CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105017</externalid>
        <name>beta-D-IdopA-(1-&gt;3)-beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796685</externalid>
        <name>2,2'-dilysocardiolipin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498744</externalid>
        <name>2-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357668</externalid>
        <name>methylseleninic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737584</externalid>
        <name>ITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9949575</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065245</externalid>
        <name>beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114830</externalid>
        <name>9H-xanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17712</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736307</externalid>
        <name>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147286</externalid>
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      <smallmolecule>
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        <name>isopentenyl diphosphate(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9941447</externalid>
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    </smallmolecules>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>AGL</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MAN2C1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MWT0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GALM</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5EA79</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CSPG5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373265</externalid>
        <name>PPP1R3C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313014</externalid>
        <name>GAPDHS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CEMIP</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKX1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10364272</externalid>
        <name>CHST1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359644</externalid>
        <name>IDS</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N2D5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ENO4</name>
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          <protein>
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              <externalid>F6RG16</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PYGM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365597</externalid>
        <name>LYVE1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6UC88</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410578</externalid>
        <name>B3GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365593</externalid>
        <name>HMMR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJE8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UGP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRELP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371264</externalid>
        <name>G6PC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148G2</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2104999</externalid>
        <name>beta-D-Galp6S-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63846</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065227</externalid>
        <name>beta-D-GalNAc4S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63519</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674785</externalid>
        <name>3-phosphonato-D-glyceroyl phosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29936</externalid>
        <name>D-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933527</externalid>
        <name>2,3-bisphosphonato-D-glycerate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065211</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841156</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-L-Fuc-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114848</externalid>
        <name>D-glyceraldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609718</externalid>
        <name>disialyl-Lewis A antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609725</externalid>
        <name>Type 2 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140918</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033794</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114814</externalid>
        <name>D-erythrose 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090071</externalid>
        <name>alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065221</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760860</externalid>
        <name>D-ribulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58121</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609723</externalid>
        <name>Type 1 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772507</externalid>
        <name>2-deoxy-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57259</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32683</externalid>
        <name>sedoheptulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090034</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63807</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861840</externalid>
        <name>beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609726</externalid>
        <name>Type 1 disialyl-paragloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40429</externalid>
        <name>1,5-anhydro-D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090062</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63811</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661284</externalid>
        <name>L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090068</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63666</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9036985</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29940</externalid>
        <name>L-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17399</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609696</externalid>
        <name>GlcNAc-beta1,3-Gal-R</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609711</externalid>
        <name>Lewis X antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033789</externalid>
        <name>alpha-D-Gal-(1-&gt;3)-alpha-D-GlcNAc-(1-&gt;4)-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31019</externalid>
        <name>beta-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065206</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63516</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38865</externalid>
        <name>1,5-anhydro-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090074</externalid>
        <name>alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841154</externalid>
        <name>beta-D-GalpNAc-(1-&gt;4)-[alpha-Neup5Ac-(2-&gt;3)]-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925918</externalid>
        <name>sedoheptulose 7-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105014</externalid>
        <name>beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609712</externalid>
        <name>Lewis Y antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29584</externalid>
        <name>D-ribofuranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47013</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105023</externalid>
        <name>beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090048</externalid>
        <name>beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63808</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114836</externalid>
        <name>alpha-D-galactose 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065205</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4,6S2-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63515</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316548</externalid>
        <name>D-glycerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661269</externalid>
        <name>3-dehydro-L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114953</externalid>
        <name>keto-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9838704</externalid>
        <name>alpha-L-Fucp-(1-&gt;4)-[beta-D-Galp-(1-&gt;3)]-beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-D-Glcp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065234</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63511</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861826</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29698</externalid>
        <name>aldehydo-D-xylose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841158</externalid>
        <name>alpha-Neup5Ac-(2-&gt;3)-beta-D-Galp-(1-&gt;4)-[alpha-L-Fucp-(1-&gt;3)]-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61711</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841155</externalid>
        <name>alpha-L-Fucp-(1-&gt;2)-beta-D-Galp-(1-&gt;3)-[alpha-L-Fucp-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090059</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63645</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090027</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63809</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090046</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105009</externalid>
        <name>beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065262</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc6S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63512</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105002</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63850</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30739</externalid>
        <name>D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933513</externalid>
        <name>alpha-D-glucose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090022</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9037617</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674776</externalid>
        <name>2-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9832973</externalid>
        <name>beta-D-fructofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105017</externalid>
        <name>beta-D-IdopA-(1-&gt;3)-beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760864</externalid>
        <name>6-phosphonatooxy-D-gluconate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065245</externalid>
        <name>beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760918</externalid>
        <name>5'-adenylyl sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58243</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30054</externalid>
        <name>xylitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17151</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105021</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9941447</externalid>
        <name>group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24433</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8982491</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70326</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5652084</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5653890</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70370</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71336</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5661270</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8853383</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9033658</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-71387</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8982491</externalid>
    <name>Glycogen metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8982491</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10371795</externalid>
        <name>GYS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314066</externalid>
        <name>GYG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314101</externalid>
        <name>PYGL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415828</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314113</externalid>
        <name>PHKA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N3K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314033</externalid>
        <name>PYGM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371826</externalid>
        <name>GBE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314094</externalid>
        <name>AGL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314049</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314053</externalid>
        <name>PHKG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373265</externalid>
        <name>PPP1R3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312920</externalid>
        <name>UGP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391280</externalid>
        <name>GAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314045</externalid>
        <name>PHKA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X778</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314073</externalid>
        <name>GYG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314117</externalid>
        <name>PHKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371833</externalid>
        <name>GYS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9X7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38865</externalid>
        <name>1,5-anhydro-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40429</externalid>
        <name>1,5-anhydro-D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3322077</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70221</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8982491</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3322077</externalid>
    <name>Glycogen synthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3322077</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314066</externalid>
        <name>GYG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371795</externalid>
        <name>GYS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373265</externalid>
        <name>PPP1R3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312920</externalid>
        <name>UGP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314073</externalid>
        <name>GYG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371826</externalid>
        <name>GBE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371833</externalid>
        <name>GYS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9X7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3322077</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8982491</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70221</externalid>
    <name>Glycogen breakdown (glycogenolysis)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70221</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314066</externalid>
        <name>GYG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314101</externalid>
        <name>PYGL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415828</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314113</externalid>
        <name>PHKA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N3K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314033</externalid>
        <name>PYGM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314094</externalid>
        <name>AGL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314049</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314053</externalid>
        <name>PHKG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391280</externalid>
        <name>GAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314073</externalid>
        <name>GYG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314045</externalid>
        <name>PHKA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X778</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314117</externalid>
        <name>PHKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38865</externalid>
        <name>1,5-anhydro-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40429</externalid>
        <name>1,5-anhydro-D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70221</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8982491</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70326</externalid>
    <name>Glucose metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70326</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312987</externalid>
        <name>HK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314287</externalid>
        <name>PFKFB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371271</externalid>
        <name>G6PC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313008</externalid>
        <name>GAPDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10096</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371251</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313993</externalid>
        <name>PGAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312991</externalid>
        <name>HK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BME6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313027</externalid>
        <name>TPI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313078</externalid>
        <name>FBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313061</externalid>
        <name>GPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314300</externalid>
        <name>G6PC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391041</externalid>
        <name>LOC112447087</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313116</externalid>
        <name>ENO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371255</externalid>
        <name>SLC37A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313999</externalid>
        <name>PGAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313036</externalid>
        <name>PFKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314281</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314159</externalid>
        <name>PKLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312929</externalid>
        <name>ALDOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407097</externalid>
        <name>PGM2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314018</externalid>
        <name>ALDOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328800</externalid>
        <name>SLC37A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313095</externalid>
        <name>PGK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334893</externalid>
        <name>PCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313104</externalid>
        <name>ENO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314153</externalid>
        <name>PKM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D984</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314012</externalid>
        <name>ALDOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313014</externalid>
        <name>GAPDHS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313048</externalid>
        <name>PFKP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313042</externalid>
        <name>PFKM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313072</externalid>
        <name>FBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313110</externalid>
        <name>ENO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313122</externalid>
        <name>ENO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RG16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312999</externalid>
        <name>HKDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312983</externalid>
        <name>GCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312910</externalid>
        <name>PFKFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314275</externalid>
        <name>PFKFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393679</externalid>
        <name>GNPDA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387857</externalid>
        <name>ADPGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313135</externalid>
        <name>PC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312995</externalid>
        <name>HK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393685</externalid>
        <name>GNPDA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371264</externalid>
        <name>G6PC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148G2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674785</externalid>
        <name>3-phosphonato-D-glyceroyl phosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933527</externalid>
        <name>2,3-bisphosphonato-D-glycerate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933513</externalid>
        <name>alpha-D-glucose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674776</externalid>
        <name>2-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-70263</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70171</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-70326</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70263</externalid>
    <name>Gluconeogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70263</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10371271</externalid>
        <name>G6PC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313008</externalid>
        <name>GAPDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10096</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371251</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313993</externalid>
        <name>PGAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313027</externalid>
        <name>TPI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313078</externalid>
        <name>FBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313061</externalid>
        <name>GPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314300</externalid>
        <name>G6PC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313116</externalid>
        <name>ENO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371255</externalid>
        <name>SLC37A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313999</externalid>
        <name>PGAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312929</externalid>
        <name>ALDOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314018</externalid>
        <name>ALDOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328800</externalid>
        <name>SLC37A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313095</externalid>
        <name>PGK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334893</externalid>
        <name>PCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313104</externalid>
        <name>ENO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314012</externalid>
        <name>ALDOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313014</externalid>
        <name>GAPDHS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313072</externalid>
        <name>FBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313110</externalid>
        <name>ENO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313122</externalid>
        <name>ENO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RG16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313135</externalid>
        <name>PC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371264</externalid>
        <name>G6PC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148G2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674785</externalid>
        <name>3-phosphonato-D-glyceroyl phosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674776</externalid>
        <name>2-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70263</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70326</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70171</externalid>
    <name>Glycolysis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70171</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312987</externalid>
        <name>HK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314287</externalid>
        <name>PFKFB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313008</externalid>
        <name>GAPDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10096</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312991</externalid>
        <name>HK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BME6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313027</externalid>
        <name>TPI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313993</externalid>
        <name>PGAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313061</externalid>
        <name>GPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391041</externalid>
        <name>LOC112447087</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313116</externalid>
        <name>ENO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313999</externalid>
        <name>PGAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313036</externalid>
        <name>PFKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314281</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314159</externalid>
        <name>PKLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312929</externalid>
        <name>ALDOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407097</externalid>
        <name>PGM2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314018</externalid>
        <name>ALDOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313095</externalid>
        <name>PGK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313104</externalid>
        <name>ENO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314153</externalid>
        <name>PKM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D984</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314012</externalid>
        <name>ALDOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313014</externalid>
        <name>GAPDHS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313048</externalid>
        <name>PFKP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313042</externalid>
        <name>PFKM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313110</externalid>
        <name>ENO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313122</externalid>
        <name>ENO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RG16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312999</externalid>
        <name>HKDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312983</externalid>
        <name>GCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312910</externalid>
        <name>PFKFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314275</externalid>
        <name>PFKFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393679</externalid>
        <name>GNPDA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387857</externalid>
        <name>ADPGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312995</externalid>
        <name>HK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393685</externalid>
        <name>GNPDA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674785</externalid>
        <name>3-phosphonato-D-glyceroyl phosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933527</externalid>
        <name>2,3-bisphosphonato-D-glycerate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933513</externalid>
        <name>alpha-D-glucose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674776</externalid>
        <name>2-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-170822</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9634600</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-70171</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70326</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-170822</externalid>
    <name>Regulation of Glucokinase by Glucokinase Regulatory Protein</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-170822</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312983</externalid>
        <name>GCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-170822</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70171</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9634600</externalid>
    <name>Regulation of glycolysis by fructose 2,6-bisphosphate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9634600</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314281</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314275</externalid>
        <name>PFKFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314287</externalid>
        <name>PFKFB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312910</externalid>
        <name>PFKFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9634600</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70171</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5652084</externalid>
    <name>Fructose metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5652084</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312938</externalid>
        <name>TKFC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312929</externalid>
        <name>ALDOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328575</externalid>
        <name>AKR1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A493UA87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381606</externalid>
        <name>SORD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393654</externalid>
        <name>GLYCTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9832973</externalid>
        <name>beta-D-fructofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316548</externalid>
        <name>D-glycerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114953</externalid>
        <name>keto-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30739</externalid>
        <name>D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114848</externalid>
        <name>D-glyceraldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5652227</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70350</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5652084</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5652227</externalid>
    <name>Fructose biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5652227</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328575</externalid>
        <name>AKR1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A493UA87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381606</externalid>
        <name>SORD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30739</externalid>
        <name>D-glucitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114953</externalid>
        <name>keto-D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48095</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5652227</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5652084</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70350</externalid>
    <name>Fructose catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70350</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312938</externalid>
        <name>TKFC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312929</externalid>
        <name>ALDOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393654</externalid>
        <name>GLYCTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9832973</externalid>
        <name>beta-D-fructofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316548</externalid>
        <name>D-glycerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114848</externalid>
        <name>D-glyceraldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70350</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5652084</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5653890</externalid>
    <name>Lactose synthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5653890</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10381704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328926</externalid>
        <name>SLC2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27674</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38687</externalid>
        <name>lactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5653890</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70370</externalid>
    <name>Galactose catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70370</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312947</externalid>
        <name>GALK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419546</externalid>
        <name>GALM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312954</externalid>
        <name>GALT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312961</externalid>
        <name>GALE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31019</externalid>
        <name>beta-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114836</externalid>
        <name>alpha-D-galactose 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70370</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71336</externalid>
    <name>Pentose phosphate pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71336</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313925</externalid>
        <name>RPE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313909</externalid>
        <name>PGLS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312970</externalid>
        <name>G6PD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389713</externalid>
        <name>DERA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QEU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313943</externalid>
        <name>TKT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z014</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313936</externalid>
        <name>RPIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E534</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315527</externalid>
        <name>PRPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315519</externalid>
        <name>PRPS1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407120</externalid>
        <name>RBKS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313916</externalid>
        <name>PGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407319</externalid>
        <name>SHPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313952</externalid>
        <name>TALDO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315513</externalid>
        <name>PRPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772507</externalid>
        <name>2-deoxy-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57259</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32683</externalid>
        <name>sedoheptulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925918</externalid>
        <name>sedoheptulose 7-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29584</externalid>
        <name>D-ribofuranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47013</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114814</externalid>
        <name>D-erythrose 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760864</externalid>
        <name>6-phosphonatooxy-D-gluconate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760860</externalid>
        <name>D-ribulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58121</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-73843</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-71336</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73843</externalid>
    <name>5-Phosphoribose 1-diphosphate biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73843</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315527</externalid>
        <name>PRPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315519</externalid>
        <name>PRPS1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315513</externalid>
        <name>PRPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73843</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71336</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1630316</externalid>
    <name>Glycosaminoglycan metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1630316</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348413</externalid>
        <name>B3GNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359695</externalid>
        <name>SGSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364506</externalid>
        <name>HS6ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359988</externalid>
        <name>OMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359711</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359686</externalid>
        <name>HPSE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400684</externalid>
        <name>UXS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364502</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361123</externalid>
        <name>CHSY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N783</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356202</externalid>
        <name>CD44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359704</externalid>
        <name>IDUA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361006</externalid>
        <name>CSGALNACT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363580</externalid>
        <name>B4GAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364324</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363171</externalid>
        <name>NDST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420439</externalid>
        <name>EXTL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343159</externalid>
        <name>GNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362240</externalid>
        <name>CHST14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364540</externalid>
        <name>HS3ST5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420160</externalid>
        <name>PXYLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYH0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325244</externalid>
        <name>PAPSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359761</externalid>
        <name>GUSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365609</externalid>
        <name>CHP1</name>
        <entity>
          <protein>
            <xref>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359950</externalid>
        <name>HYAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350944</externalid>
        <name>B4GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RH18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359983</externalid>
        <name>OGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361113</externalid>
        <name>CHPF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365597</externalid>
        <name>LYVE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6UC88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359968</externalid>
        <name>FMOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13605</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365576</externalid>
        <name>HAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365593</externalid>
        <name>HMMR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350932</externalid>
        <name>B4GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359993</externalid>
        <name>PRELP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361065</externalid>
        <name>CHST11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N663</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364528</externalid>
        <name>HS3ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2104999</externalid>
        <name>beta-D-Galp6S-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63846</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065206</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63516</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065227</externalid>
        <name>beta-D-GalNAc4S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63519</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090074</externalid>
        <name>alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065211</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105014</externalid>
        <name>beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105023</externalid>
        <name>beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090048</externalid>
        <name>beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63808</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065205</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4,6S2-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63515</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090071</externalid>
        <name>alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065234</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63511</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065221</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29698</externalid>
        <name>aldehydo-D-xylose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090059</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63645</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090027</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63809</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090046</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105009</externalid>
        <name>beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090034</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63807</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065262</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc6S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63512</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105002</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63850</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090022</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090062</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63811</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105017</externalid>
        <name>beta-D-IdopA-(1-&gt;3)-beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090068</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63666</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065245</externalid>
        <name>beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760918</externalid>
        <name>5'-adenylyl sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58243</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105021</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9941447</externalid>
        <name>group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24433</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2142845</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174362</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638074</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1971475</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638091</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1793185</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1630316</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142845</externalid>
    <name>Hyaluronan metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142845</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365609</externalid>
        <name>CHP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365601</externalid>
        <name>STAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387189</externalid>
        <name>CEMIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365568</externalid>
        <name>HAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359950</externalid>
        <name>HYAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341754</externalid>
        <name>SLC9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356218</externalid>
        <name>ABCC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365589</externalid>
        <name>HYAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365597</externalid>
        <name>LYVE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6UC88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365576</externalid>
        <name>HAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365593</externalid>
        <name>HMMR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359954</externalid>
        <name>HYAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356202</externalid>
        <name>CD44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365572</externalid>
        <name>DERPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359761</externalid>
        <name>GUSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2160916</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2142845</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2160916</externalid>
    <name>Hyaluronan degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2160916</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365601</externalid>
        <name>STAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365609</externalid>
        <name>CHP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387189</externalid>
        <name>CEMIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359950</externalid>
        <name>HYAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341754</externalid>
        <name>SLC9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365589</externalid>
        <name>HYAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365597</externalid>
        <name>LYVE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6UC88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365593</externalid>
        <name>HMMR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359954</externalid>
        <name>HYAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356202</externalid>
        <name>CD44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359761</externalid>
        <name>GUSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2160913</externalid>
        <name>beta-D-GlcpA-(1-&gt;3)-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64024</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2160916</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142845</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174362</externalid>
    <name>Transport and metabolism of PAPS</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174362</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347108</externalid>
        <name>SLC35B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325248</externalid>
        <name>PAPSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342007</externalid>
        <name>SLC26A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342003</externalid>
        <name>SLC26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3P2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402710</externalid>
        <name>SLC26A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325244</externalid>
        <name>PAPSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347104</externalid>
        <name>SLC35B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760918</externalid>
        <name>5'-adenylyl sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58243</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174362</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1638074</externalid>
    <name>Keratan sulfate/keratin metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1638074</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348413</externalid>
        <name>B3GNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348409</externalid>
        <name>B3GNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359973</externalid>
        <name>KERA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T890</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361878</externalid>
        <name>CHST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359988</externalid>
        <name>OMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359978</externalid>
        <name>LUM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348417</externalid>
        <name>B3GNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359963</externalid>
        <name>ACAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N368</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348425</externalid>
        <name>B3GNT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364272</externalid>
        <name>CHST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363580</externalid>
        <name>B4GAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364320</externalid>
        <name>CHST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364324</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350944</externalid>
        <name>B4GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RH18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359983</externalid>
        <name>OGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343159</externalid>
        <name>GNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359968</externalid>
        <name>FMOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13605</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350932</externalid>
        <name>B4GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358872</externalid>
        <name>GALNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359993</externalid>
        <name>PRELP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2104999</externalid>
        <name>beta-D-Galp6S-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63846</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105009</externalid>
        <name>beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105002</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63850</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105014</externalid>
        <name>beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105021</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2022854</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2022857</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1638074</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022854</externalid>
    <name>Keratan sulfate biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022854</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348413</externalid>
        <name>B3GNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348409</externalid>
        <name>B3GNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359973</externalid>
        <name>KERA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T890</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361878</externalid>
        <name>CHST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359988</externalid>
        <name>OMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359978</externalid>
        <name>LUM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348417</externalid>
        <name>B3GNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359963</externalid>
        <name>ACAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N368</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348425</externalid>
        <name>B3GNT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364272</externalid>
        <name>CHST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363580</externalid>
        <name>B4GAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364320</externalid>
        <name>CHST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364324</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350944</externalid>
        <name>B4GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RH18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359983</externalid>
        <name>OGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359968</externalid>
        <name>FMOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13605</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350932</externalid>
        <name>B4GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359993</externalid>
        <name>PRELP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638074</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022857</externalid>
    <name>Keratan sulfate degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022857</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359973</externalid>
        <name>KERA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T890</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359988</externalid>
        <name>OMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359978</externalid>
        <name>LUM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359983</externalid>
        <name>OGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359968</externalid>
        <name>FMOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13605</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343159</externalid>
        <name>GNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358872</externalid>
        <name>GALNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359993</externalid>
        <name>PRELP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359963</externalid>
        <name>ACAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N368</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2104999</externalid>
        <name>beta-D-Galp6S-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63846</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105002</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63850</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105009</externalid>
        <name>beta-D-GlcpNAc6S-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105014</externalid>
        <name>beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105021</externalid>
        <name>beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc6S-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022857</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638074</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1971475</externalid>
    <name>Glycosaminoglycan-protein linkage region biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1971475</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359201</externalid>
        <name>GPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359917</externalid>
        <name>VCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342294</externalid>
        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360543</externalid>
        <name>XYLT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359183</externalid>
        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400684</externalid>
        <name>UXS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359902</externalid>
        <name>CSPG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360628</externalid>
        <name>B3GAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LG25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360704</externalid>
        <name>B3GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360634</externalid>
        <name>B3GAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420167</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359912</externalid>
        <name>NCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359888</externalid>
        <name>BCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360711</externalid>
        <name>B4GALT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D1H0P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360539</externalid>
        <name>XYLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N211</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420160</externalid>
        <name>PXYLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1971475</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1638091</externalid>
    <name>Heparan sulfate/heparin (HS-GAG) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1638091</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363059</externalid>
        <name>EXT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359201</externalid>
        <name>GPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363179</externalid>
        <name>NDST4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363175</externalid>
        <name>NDST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B729</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359695</externalid>
        <name>SGSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364506</externalid>
        <name>HS6ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342294</externalid>
        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359686</externalid>
        <name>HPSE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359711</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363063</externalid>
        <name>EXT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364532</externalid>
        <name>HS3ST3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359183</externalid>
        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364502</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364519</externalid>
        <name>HS2ST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359704</externalid>
        <name>IDUA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364510</externalid>
        <name>HS6ST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359265</externalid>
        <name>HPSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359644</externalid>
        <name>IDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359655</externalid>
        <name>HGSNAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364493</externalid>
        <name>HS3ST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364536</externalid>
        <name>HS3ST3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363171</externalid>
        <name>NDST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420439</externalid>
        <name>EXTL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364540</externalid>
        <name>HS3ST5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364528</externalid>
        <name>HS3ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2090027</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63809</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090034</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63807</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090074</externalid>
        <name>alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090022</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090048</externalid>
        <name>beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63808</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090062</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63811</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090068</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63666</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090071</externalid>
        <name>alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090059</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63645</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9941447</externalid>
        <name>group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24433</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2022928</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2024096</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1638091</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022928</externalid>
    <name>HS-GAG biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022928</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359201</externalid>
        <name>GPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363059</externalid>
        <name>EXT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363175</externalid>
        <name>NDST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363179</externalid>
        <name>NDST4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364544</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B729</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342294</externalid>
        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364506</externalid>
        <name>HS6ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363063</externalid>
        <name>EXT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359183</externalid>
        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364532</externalid>
        <name>HS3ST3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364502</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364519</externalid>
        <name>HS2ST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364510</externalid>
        <name>HS6ST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364493</externalid>
        <name>HS3ST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364536</externalid>
        <name>HS3ST3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363171</externalid>
        <name>NDST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420439</externalid>
        <name>EXTL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364540</externalid>
        <name>HS3ST5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364528</externalid>
        <name>HS3ST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022928</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638091</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2024096</externalid>
    <name>HS-GAG degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2024096</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359201</externalid>
        <name>GPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359265</externalid>
        <name>HPSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359695</externalid>
        <name>SGSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359644</externalid>
        <name>IDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359655</externalid>
        <name>HGSNAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342294</externalid>
        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359711</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359686</externalid>
        <name>HPSE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359183</externalid>
        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359704</externalid>
        <name>IDUA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2090027</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63809</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090048</externalid>
        <name>beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63808</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090062</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63811</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090034</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63807</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090074</externalid>
        <name>alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090068</externalid>
        <name>beta-D-IdoA-(1-&gt;4)-alpha-D-GlcNS6S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63666</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090071</externalid>
        <name>alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090022</externalid>
        <name>alpha-D-GlcN-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;4)-alpha-D-GlcNS3S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2090059</externalid>
        <name>alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63645</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9941447</externalid>
        <name>group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24433</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2024096</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1638091</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1793185</externalid>
    <name>Chondroitin sulfate/dermatan sulfate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1793185</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359917</externalid>
        <name>VCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361119</externalid>
        <name>CHSY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PU96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361878</externalid>
        <name>CHST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361882</externalid>
        <name>CHST7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361010</externalid>
        <name>CSGALNACT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359902</externalid>
        <name>CSPG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361077</externalid>
        <name>CHST9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361123</externalid>
        <name>CHSY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N783</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361848</externalid>
        <name>CHST15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359704</externalid>
        <name>IDUA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361006</externalid>
        <name>CSGALNACT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361073</externalid>
        <name>CHST13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361069</externalid>
        <name>CHST12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M362</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359644</externalid>
        <name>IDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359950</externalid>
        <name>HYAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362213</externalid>
        <name>UST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359912</externalid>
        <name>NCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361941</externalid>
        <name>DSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361113</externalid>
        <name>CHPF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361945</externalid>
        <name>DSEL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359888</externalid>
        <name>BCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361109</externalid>
        <name>CHPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362240</externalid>
        <name>CHST14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359954</externalid>
        <name>HYAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361065</externalid>
        <name>CHST11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N663</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359761</externalid>
        <name>GUSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2090046</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065206</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63516</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065227</externalid>
        <name>beta-D-GalNAc4S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63519</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065262</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc6S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63512</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065211</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105023</externalid>
        <name>beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065205</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4,6S2-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63515</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105017</externalid>
        <name>beta-D-IdopA-(1-&gt;3)-beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065234</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63511</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065245</externalid>
        <name>beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065221</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29698</externalid>
        <name>aldehydo-D-xylose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2022870</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2022923</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2024101</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1793185</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1630316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022870</externalid>
    <name>CS-GAG biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022870</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359917</externalid>
        <name>VCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361006</externalid>
        <name>CSGALNACT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361073</externalid>
        <name>CHST13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361069</externalid>
        <name>CHST12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M362</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361119</externalid>
        <name>CHSY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PU96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361878</externalid>
        <name>CHST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362213</externalid>
        <name>UST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361882</externalid>
        <name>CHST7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361010</externalid>
        <name>CSGALNACT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359912</externalid>
        <name>NCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361113</externalid>
        <name>CHPF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359888</externalid>
        <name>BCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359902</externalid>
        <name>CSPG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361077</externalid>
        <name>CHST9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361109</externalid>
        <name>CHPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361123</externalid>
        <name>CHSY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N783</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361848</externalid>
        <name>CHST15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361065</externalid>
        <name>CHST11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N663</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022870</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1793185</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022923</externalid>
    <name>DS-GAG biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022923</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361945</externalid>
        <name>DSEL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359917</externalid>
        <name>VCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359888</externalid>
        <name>BCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359902</externalid>
        <name>CSPG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362240</externalid>
        <name>CHST14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361848</externalid>
        <name>CHST15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362213</externalid>
        <name>UST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359912</externalid>
        <name>NCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361941</externalid>
        <name>DSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022923</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1793185</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2024101</externalid>
    <name>CS/DS degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2024101</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359917</externalid>
        <name>VCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359644</externalid>
        <name>IDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359950</externalid>
        <name>HYAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98187</externalid>
        <name>BGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21809</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359912</externalid>
        <name>NCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359907</externalid>
        <name>DCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359888</externalid>
        <name>BCAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359902</externalid>
        <name>CSPG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359954</externalid>
        <name>HYAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359897</externalid>
        <name>CSPG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359704</externalid>
        <name>IDUA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359761</externalid>
        <name>GUSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2090046</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065206</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63516</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065227</externalid>
        <name>beta-D-GalNAc4S-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63519</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065205</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4,6S2-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63515</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105017</externalid>
        <name>beta-D-IdopA-(1-&gt;3)-beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065262</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc6S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63512</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29718</externalid>
        <name>D-glucuronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4178</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065211</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065234</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63511</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065245</externalid>
        <name>beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2065221</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-beta-D-IdoA2S-(1-&gt;3)-beta-D-GalNAc4S-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29698</externalid>
        <name>aldehydo-D-xylose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2105023</externalid>
        <name>beta-D-GalpNAc4S-(1-&gt;4)-beta-D-GlcpA-(1-&gt;3)-beta-D-Galp-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-beta-D-Xylp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773098</externalid>
        <name>aldehydo-L-iduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21338</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2024101</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1793185</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5661270</externalid>
    <name>Formation of xylulose-5-phosphate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5661270</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10382409</externalid>
        <name>DCXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382431</externalid>
        <name>CRYL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381606</externalid>
        <name>SORD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382424</externalid>
        <name>AKR1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382448</externalid>
        <name>XYLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382413</externalid>
        <name>DCXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JP75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661284</externalid>
        <name>L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29936</externalid>
        <name>D-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661269</externalid>
        <name>3-dehydro-L-gulonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29940</externalid>
        <name>L-xylulose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17399</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30054</externalid>
        <name>xylitol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17151</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5661270</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8853383</externalid>
    <name>Lysosomal oligosaccharide catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8853383</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10393661</externalid>
        <name>MAN2C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391124</externalid>
        <name>MANBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392923</externalid>
        <name>MAN2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29451</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861840</externalid>
        <name>beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861826</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91279</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8853383</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9033658</externalid>
    <name>Blood group systems biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9033658</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400077</externalid>
        <name>B4GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410636</externalid>
        <name>FUT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410564</externalid>
        <name>FUT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N751</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410582</externalid>
        <name>B3GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410426</externalid>
        <name>FUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410586</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410578</externalid>
        <name>B3GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410558</externalid>
        <name>FUT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387378</externalid>
        <name>FUT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410383</externalid>
        <name>FUT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q1T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609725</externalid>
        <name>Type 2 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140918</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033794</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841154</externalid>
        <name>beta-D-GalpNAc-(1-&gt;4)-[alpha-Neup5Ac-(2-&gt;3)]-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9838704</externalid>
        <name>alpha-L-Fucp-(1-&gt;4)-[beta-D-Galp-(1-&gt;3)]-beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-D-Glcp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9036985</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9037617</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609696</externalid>
        <name>GlcNAc-beta1,3-Gal-R</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609726</externalid>
        <name>Type 1 disialyl-paragloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609712</externalid>
        <name>Lewis Y antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609723</externalid>
        <name>Type 1 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609711</externalid>
        <name>Lewis X antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841156</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-L-Fuc-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033789</externalid>
        <name>alpha-D-Gal-(1-&gt;3)-alpha-D-GlcNAc-(1-&gt;4)-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609718</externalid>
        <name>disialyl-Lewis A antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841158</externalid>
        <name>alpha-Neup5Ac-(2-&gt;3)-beta-D-Galp-(1-&gt;4)-[alpha-L-Fucp-(1-&gt;3)]-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61711</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841155</externalid>
        <name>alpha-L-Fucp-(1-&gt;2)-beta-D-Galp-(1-&gt;3)-[alpha-L-Fucp-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59440</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9033807</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9037629</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9033658</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71387</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9033807</externalid>
    <name>ABO blood group biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9033807</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10410426</externalid>
        <name>FUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410383</externalid>
        <name>FUT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q1T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9036985</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9037617</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033794</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033789</externalid>
        <name>alpha-D-Gal-(1-&gt;3)-alpha-D-GlcNAc-(1-&gt;4)-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9033807</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9033658</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9037629</externalid>
    <name>Lewis blood group biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9037629</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400077</externalid>
        <name>B4GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410636</externalid>
        <name>FUT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410564</externalid>
        <name>FUT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N751</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410582</externalid>
        <name>B3GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410426</externalid>
        <name>FUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410586</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410578</externalid>
        <name>B3GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410558</externalid>
        <name>FUT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387378</externalid>
        <name>FUT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609725</externalid>
        <name>Type 2 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140918</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841154</externalid>
        <name>beta-D-GalpNAc-(1-&gt;4)-[alpha-Neup5Ac-(2-&gt;3)]-beta-D-Galp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;3)-D-Galp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9838704</externalid>
        <name>alpha-L-Fucp-(1-&gt;4)-[beta-D-Galp-(1-&gt;3)]-beta-D-GlcpNAc-(1-&gt;3)-beta-D-Galp-(1-&gt;4)-D-Glcp</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9036985</externalid>
        <name>beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-alpha-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609696</externalid>
        <name>GlcNAc-beta1,3-Gal-R</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609726</externalid>
        <name>Type 1 disialyl-paragloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609712</externalid>
        <name>Lewis Y antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609723</externalid>
        <name>Type 1 monosialylgalactosylgloboside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609711</externalid>
        <name>Lewis X antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841156</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-L-Fuc-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9033789</externalid>
        <name>alpha-D-Gal-(1-&gt;3)-alpha-D-GlcNAc-(1-&gt;4)-D-Gal-yl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9609718</externalid>
        <name>disialyl-Lewis A antigen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841158</externalid>
        <name>alpha-Neup5Ac-(2-&gt;3)-beta-D-Galp-(1-&gt;4)-[alpha-L-Fucp-(1-&gt;3)]-D-GlcpNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61711</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841155</externalid>
        <name>alpha-L-Fucp-(1-&gt;2)-beta-D-Galp-(1-&gt;3)-[alpha-L-Fucp-(1-&gt;4)]-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59440</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9037629</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9033658</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483249</externalid>
    <name>Inositol phosphate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483249</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319456</externalid>
        <name>PLCB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360269</externalid>
        <name>INPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21327</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360148</externalid>
        <name>NUDT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360284</externalid>
        <name>INPP5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360220</externalid>
        <name>PPIP5K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z050</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360335</externalid>
        <name>PLCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359441</externalid>
        <name>INPP5J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329812</externalid>
        <name>PTEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360129</externalid>
        <name>MINPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352882</externalid>
        <name>ITPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360103</externalid>
        <name>IP6K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360082</externalid>
        <name>IMPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360323</externalid>
        <name>PLCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10895</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360329</externalid>
        <name>PLCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348130</externalid>
        <name>INPPL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360057</externalid>
        <name>ITPKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360351</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383827</externalid>
        <name>MIOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360069</externalid>
        <name>ITPKC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360063</externalid>
        <name>ITPKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360224</externalid>
        <name>PPIP5K2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360345</externalid>
        <name>PLCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360107</externalid>
        <name>IP6K2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360233</externalid>
        <name>IPMK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1W2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360090</externalid>
        <name>IMPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360189</externalid>
        <name>PLCZ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360295</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360136</externalid>
        <name>NUDT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359591</externalid>
        <name>INPP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B820</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360142</externalid>
        <name>NUDT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359595</externalid>
        <name>INPP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360176</externalid>
        <name>IPPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360200</externalid>
        <name>ISYNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9966606</externalid>
        <name>1D-myo-inositol 1,4-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760975</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760797</externalid>
        <name>1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629757</externalid>
        <name>1-diphospho-1D-myo-inositol 3,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760980</externalid>
        <name>1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629742</externalid>
        <name>5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966599</externalid>
        <name>1D-myo-inositol 1,3-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966601</externalid>
        <name>1D-myo-inositol 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966612</externalid>
        <name>1D-myo-inositol 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966589</externalid>
        <name>5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate(11-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629743</externalid>
        <name>3-diphospho-1D-myo-inositol 1,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966611</externalid>
        <name>1D-myo-inositol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58401</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966362</externalid>
        <name>1D-myo-inositol 3,4,6-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629752</externalid>
        <name>5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760908</externalid>
        <name>5-diphospho-1D-myo-inositol pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966603</externalid>
        <name>1D-myo-inositol 3,4-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966593</externalid>
        <name>D-glucopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966598</externalid>
        <name>1D-myo-inositol 1,2,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57798</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760986</externalid>
        <name>3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629758</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760984</externalid>
        <name>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140372</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1855204</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1855191</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1855167</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1855231</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1855183</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1483249</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1855204</externalid>
    <name>Synthesis of IP3 and IP4 in the cytosol</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1855204</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10319456</externalid>
        <name>PLCB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360284</externalid>
        <name>INPP5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360335</externalid>
        <name>PLCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359441</externalid>
        <name>INPP5J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329812</externalid>
        <name>PTEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352882</externalid>
        <name>ITPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360323</externalid>
        <name>PLCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10895</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360329</externalid>
        <name>PLCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348130</externalid>
        <name>INPPL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360351</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360057</externalid>
        <name>ITPKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360069</externalid>
        <name>ITPKC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360063</externalid>
        <name>ITPKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360345</externalid>
        <name>PLCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360295</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360189</externalid>
        <name>PLCZ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966362</externalid>
        <name>1D-myo-inositol 3,4,6-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1855204</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1855191</externalid>
    <name>Synthesis of IPs in the nucleus</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1855191</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360107</externalid>
        <name>IP6K2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360233</externalid>
        <name>IPMK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1W2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360103</externalid>
        <name>IP6K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360176</externalid>
        <name>IPPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9966589</externalid>
        <name>5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate(11-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760975</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629752</externalid>
        <name>5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760908</externalid>
        <name>5-diphospho-1D-myo-inositol pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760980</externalid>
        <name>1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760798</externalid>
        <name>myo-inositol 1,3,4,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629758</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1855191</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1855167</externalid>
    <name>Synthesis of pyrophosphates in the cytosol</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1855167</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360148</externalid>
        <name>NUDT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360220</externalid>
        <name>PPIP5K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z050</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352882</externalid>
        <name>ITPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360136</externalid>
        <name>NUDT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360103</externalid>
        <name>IP6K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360142</externalid>
        <name>NUDT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360176</externalid>
        <name>IPPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360224</externalid>
        <name>PPIP5K2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1629743</externalid>
        <name>3-diphospho-1D-myo-inositol 1,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760975</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760797</externalid>
        <name>1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629752</externalid>
        <name>5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760908</externalid>
        <name>5-diphospho-1D-myo-inositol pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629757</externalid>
        <name>1-diphospho-1D-myo-inositol 3,4,5,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629742</externalid>
        <name>5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760980</externalid>
        <name>1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760986</externalid>
        <name>3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760984</externalid>
        <name>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate(13-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1629758</externalid>
        <name>1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62931</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1855167</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1855231</externalid>
    <name>Synthesis of IPs in the ER lumen</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1855231</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360129</externalid>
        <name>MINPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760866</externalid>
        <name>1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760850</externalid>
        <name>myo-inositol hexakisphosphate(12-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966598</externalid>
        <name>1D-myo-inositol 1,2,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57798</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760790</externalid>
        <name>myo-inositol 1,3,4,5,6-pentakisphosphate(10-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57733</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1855231</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1855183</externalid>
    <name>Synthesis of IP2, IP, and Ins in the cytosol</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1855183</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359441</externalid>
        <name>INPP5J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360082</externalid>
        <name>IMPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360269</externalid>
        <name>INPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21327</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383827</externalid>
        <name>MIOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360284</externalid>
        <name>INPP5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360090</externalid>
        <name>IMPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359591</externalid>
        <name>INPP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B820</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD64</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359595</externalid>
        <name>INPP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSR1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360200</externalid>
        <name>ISYNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9966606</externalid>
        <name>1D-myo-inositol 1,4-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317403</externalid>
        <name>D-glucopyranuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966611</externalid>
        <name>1D-myo-inositol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58401</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966603</externalid>
        <name>1D-myo-inositol 3,4-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966599</externalid>
        <name>1D-myo-inositol 1,3-biphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760922</externalid>
        <name>1D-myo-inositol 1,3,4-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966601</externalid>
        <name>1D-myo-inositol 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966612</externalid>
        <name>1D-myo-inositol 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9966593</externalid>
        <name>D-glucopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61548</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1855183</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
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  <biosystem>
    <externalid>R-BTA-556833</externalid>
    <name>Metabolism of lipids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-556833</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
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      <gene>
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        <name>AGK</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QR07</externalid>
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      <gene>
        <externalid>10358443</externalid>
        <name>GLA</name>
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          <protein>
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              <externalid>E1B725</externalid>
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      <gene>
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        <name>LPCAT3</name>
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          <protein>
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              <externalid>G8JL05</externalid>
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      <gene>
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        <name>CDS2</name>
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          <protein>
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              <externalid>A0JNC1</externalid>
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      <gene>
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              <externalid>F1MND2</externalid>
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      <gene>
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        <name>PLA2G5</name>
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              <externalid>E1BEG8</externalid>
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      <gene>
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        <name>MIGA1</name>
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          <protein>
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              <externalid>F1MNB3</externalid>
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      <gene>
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        <name>CERS6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BP45</externalid>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1LGQ6</externalid>
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          <protein>
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              <externalid>F1MX52</externalid>
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      <gene>
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              <externalid>O46629</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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              <externalid>A6QL88</externalid>
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      <gene>
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              <externalid>E1BG28</externalid>
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      <gene>
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        <name>TNFAIP8</name>
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          <protein>
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              <externalid>A4IF78</externalid>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914021</externalid>
        <name>(R)-4,8-dimethylnonanoylcarnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2046043</externalid>
        <name>(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63543</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605734</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694562</externalid>
        <name>acyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22221</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498721</externalid>
        <name>1-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>428282</externalid>
        <name>trans-hexadec-2-enal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840469</externalid>
        <name>PE(18:0/16:1(9Z)) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842019</externalid>
        <name>(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024565</externalid>
        <name>7S,8S-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6811611</externalid>
        <name>pristanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916398</externalid>
        <name>17(R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327984</externalid>
        <name>4-methylpentan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874449</externalid>
        <name>glycerophosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916381</externalid>
        <name>(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843245</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913882</externalid>
        <name>2-oxohexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915969</externalid>
        <name>(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024571</externalid>
        <name>aspirin-triggered resolvin D1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024476</externalid>
        <name>7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138602</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024587</externalid>
        <name>4S(5)-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845603</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNac-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87787</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874445</externalid>
        <name>glycerophosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916411</externalid>
        <name>18(R)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018639</externalid>
        <name>calcitroic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31383</externalid>
        <name>5alpha-cholest-7-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760848</externalid>
        <name>CDP-ethanolamine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34859</externalid>
        <name>all-cis-icosa-8,11,14-trienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1660672</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024856</externalid>
        <name>resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865932</externalid>
        <name>O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945788</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395905</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65131</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36927</externalid>
        <name>7-dehydrodesmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429777</externalid>
        <name>sphingomyelin d18:1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915837</externalid>
        <name>12(S)-HHTrE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762300</externalid>
        <name>(4Z,7Z,10Z,14E,16Z,19Z)-13-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865933</externalid>
        <name>(R)-3-hydroxyacyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8932800</externalid>
        <name>meadowlactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498742</externalid>
        <name>2-acyl-sn-glycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845499</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916392</externalid>
        <name>5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915975</externalid>
        <name>(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913884</externalid>
        <name>formyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166601</externalid>
        <name>trans-dec-3-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841183</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916409</externalid>
        <name>protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865943</externalid>
        <name>O-[S-(3R)-3-hydroxyacylpantetheine-4'-phosphoryl]serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914033</externalid>
        <name>4,8,12-trimethyltridecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023704</externalid>
        <name>5S(6)-epoxy-18(R)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024580</externalid>
        <name>aspirin-triggered resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045968</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327673</externalid>
        <name>1-hexadecyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022663</externalid>
        <name>5(S)6-epoxy-18(S)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915870</externalid>
        <name>20-oxoleukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>77356</externalid>
        <name>3-oxo-fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15489</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916396</externalid>
        <name>22-hydroxyprotectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843874</externalid>
        <name>phytosphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760862</externalid>
        <name>(R)-5-phosphonatomevalonate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843243</externalid>
        <name>N-hexadecanoylsphinganine-1-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916421</externalid>
        <name>resolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132079</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913867</externalid>
        <name>phytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57391</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498727</externalid>
        <name>1-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34065</externalid>
        <name>gamma-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15508</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164584</externalid>
        <name>1-acylglycerophosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022662</externalid>
        <name>resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32647</externalid>
        <name>linoleoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840473</externalid>
        <name>1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915891</externalid>
        <name>12(R)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840463</externalid>
        <name>PE(16:1(9Z)/16:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163917</externalid>
        <name>zymosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024897</externalid>
        <name>(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138653</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024488</externalid>
        <name>4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911702</externalid>
        <name>(7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914018</externalid>
        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782158</externalid>
        <name>2-methylpentadecenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327668</externalid>
        <name>3-hydroxypristanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045963</externalid>
        <name>alpha-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>51985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945113</externalid>
        <name>presqualene diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840849</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845542</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29930</externalid>
        <name>CDP-choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36929</externalid>
        <name>14-demethyllanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865947</externalid>
        <name>trans-2-octadecenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945806</externalid>
        <name>3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915967</externalid>
        <name>(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760985</externalid>
        <name>3-oxohexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73980</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971091</externalid>
        <name>O-lauroyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77086</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025146</externalid>
        <name>10(S),17(S)-dihydroxy-omega 6-docosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138674</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945104</externalid>
        <name>4beta-methylzymosterol-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915976</externalid>
        <name>16-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30018</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916747</externalid>
        <name>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137442</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945793</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840447</externalid>
        <name>PE(16:1(9Z)/14:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31423</externalid>
        <name>(R)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15465</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695975</externalid>
        <name>2,3-dehydrobehenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025156</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916771</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024861</externalid>
        <name>4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30565</externalid>
        <name>(S)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916416</externalid>
        <name>17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498723</externalid>
        <name>2-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142798</externalid>
        <name>15-epi-lipoxin B4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024581</externalid>
        <name>aspirin-triggered resolvin D2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916384</externalid>
        <name>15-oxolipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78311</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045960</externalid>
        <name>(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023656</externalid>
        <name>(18R)-resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916382</externalid>
        <name>18(S)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132083</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916751</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911706</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140260</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915898</externalid>
        <name>hepoxilin B3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878652</externalid>
        <name>1-myristoyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845501</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945090</externalid>
        <name>presqualene monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498776</externalid>
        <name>2-monolysocardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916405</externalid>
        <name>17-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913889</externalid>
        <name>(2S)-pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498720</externalid>
        <name>2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161607</externalid>
        <name>malonaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>566274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5250592</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37145</externalid>
        <name>(3Z,6Z)-dodecadienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395906</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844857</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846339</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023697</externalid>
        <name>(5Z,8Z,11Z,14Z,16E,18R)-18-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914041</externalid>
        <name>4,8-dimethylnonanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498741</externalid>
        <name>1-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915863</externalid>
        <name>20-hydroxy-20-oxoleukotriene B4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841192</externalid>
        <name>steroid sulfate oxoanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946136</externalid>
        <name>4,4-dimethyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760974</externalid>
        <name>tetracosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>195686</externalid>
        <name>5alpha-cholesta-7,24-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840845</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;3)-alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913892</externalid>
        <name>2-hydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9020465</externalid>
        <name>(18S)-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874448</externalid>
        <name>1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914140</externalid>
        <name>4-saturated-trans-3-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915899</externalid>
        <name>5-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8865641</externalid>
        <name>lysophosphatidylcholine 22:6</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913887</externalid>
        <name>2-hydroxyphytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694471</externalid>
        <name>lysophosphatidylcholine 14:0</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6813741</externalid>
        <name>1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58444</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31337</externalid>
        <name>cholesta-5,7-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915650</externalid>
        <name>11-epi-prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33991</externalid>
        <name>O-palmitoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317270</externalid>
        <name>sphingoid 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395901</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946143</externalid>
        <name>4,4-dimethyl-8,14-cholestadien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045964</externalid>
        <name>(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31211</externalid>
        <name>(R)-3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911731</externalid>
        <name>(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842381</externalid>
        <name>(4E)-unsatiated ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914035</externalid>
        <name>3-oxopristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498745</externalid>
        <name>2-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782159</externalid>
        <name>2-methylpentadec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846338</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37143</externalid>
        <name>(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395396</externalid>
        <name>pregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085431</externalid>
        <name>ferricytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914124</externalid>
        <name>S-acyl-4'-phosphopantetheine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916399</externalid>
        <name>(17S)-HDHA(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916404</externalid>
        <name>resolvin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914043</externalid>
        <name>(E)-2,3-didehydropristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975651</externalid>
        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>389633</externalid>
        <name>pristanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844864</externalid>
        <name>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915917</externalid>
        <name>12(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914122</externalid>
        <name>cis-3-octenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841796</externalid>
        <name>3-dehydrosphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843200</externalid>
        <name>(2R)-2-hydroxy fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760972</externalid>
        <name>3-oxooctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844848</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395389</externalid>
        <name>17alpha-hydroxypregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31165</externalid>
        <name>(S)-2,3-epoxysqualene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865940</externalid>
        <name>3-hydroxyoctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024866</externalid>
        <name>resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762227</externalid>
        <name>1-palmitoylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58303</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36931</externalid>
        <name>24,25-dihydrolanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844852</externalid>
        <name>ganglioside GM2 (18:0) (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316542</externalid>
        <name>N-acylphytosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842386</externalid>
        <name>phytoceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045959</externalid>
        <name>(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696452</externalid>
        <name>(R)-3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024860</externalid>
        <name>7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916394</externalid>
        <name>(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911735</externalid>
        <name>prostaglandin H3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916385</externalid>
        <name>lipoxin B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760979</externalid>
        <name>3-oxodocosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845517</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32285</externalid>
        <name>desmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945782</externalid>
        <name>5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841240</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844331</externalid>
        <name>sphinganine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317273</externalid>
        <name>sphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8934415</externalid>
        <name>1-monomyristoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916383</externalid>
        <name>aspirin-triggered protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045962</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840994</externalid>
        <name>choline phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>295975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9038578</externalid>
        <name>(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140196</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914118</externalid>
        <name>hexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916001</externalid>
        <name>20-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846303</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78569</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760814</externalid>
        <name>sphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57756</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914048</externalid>
        <name>O-propanoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045961</externalid>
        <name>(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317274</externalid>
        <name>(R)-mevalonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024864</externalid>
        <name>4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605616</externalid>
        <name>N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142720</externalid>
        <name>6-epi-lipoxin A4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911738</externalid>
        <name>5-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865938</externalid>
        <name>(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945824</externalid>
        <name>3beta-hydroxy-4beta-methyl-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166589</externalid>
        <name>cis-dec-4-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845579</externalid>
        <name>ganglioside GD3(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142812</externalid>
        <name>5,6-DHET</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760741</externalid>
        <name>icosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57380</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841056</externalid>
        <name>sphingomyelin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915995</externalid>
        <name>17-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5228369</externalid>
        <name>alpha-Neu5NAc-(2-&gt;8)-alpha-Neu5NAc-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915909</externalid>
        <name>12-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945112</externalid>
        <name>4alpha-carboxyzymosterol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166604</externalid>
        <name>(2E,4Z)-deca-2,4-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696109</externalid>
        <name>alkylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916380</externalid>
        <name>8-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845590</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30793</externalid>
        <name>hexadecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945089</externalid>
        <name>prenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914137</externalid>
        <name>(R)-3-hydroxyhexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694585</externalid>
        <name>N-arachidonoylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874441</externalid>
        <name>1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945105</externalid>
        <name>geranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843244</externalid>
        <name>N-hexadecanoylsphinganine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843204</externalid>
        <name>2-saturated fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911700</externalid>
        <name>(4Z,8E,10Z,13Z,16Z,19Z)-7-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914135</externalid>
        <name>trans-2-hexacosenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914133</externalid>
        <name>trans,trans-2,4-dienoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30291</externalid>
        <name>hexadecanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085422</externalid>
        <name>ferrocytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916402</externalid>
        <name>18-oxoresolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848505</externalid>
        <name>palmityl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30050</externalid>
        <name>steroid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045965</externalid>
        <name>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762310</externalid>
        <name>stearoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57394</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142681</externalid>
        <name>eoxin C4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63984</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840626</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915895</externalid>
        <name>eoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694561</externalid>
        <name>N-acylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36923</externalid>
        <name>4alpha-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395904</externalid>
        <name>(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327983</externalid>
        <name>3-dehydro-4-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842378</externalid>
        <name>dihydroceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865942</externalid>
        <name>2,3-trans-enoyl CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796685</externalid>
        <name>2,2'-dilysocardiolipin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695948</externalid>
        <name>docosanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498744</externalid>
        <name>2-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9949575</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840456</externalid>
        <name>1-oleoyl-2-palmitoleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36715</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide(d18:1(4E))</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865941</externalid>
        <name>oleoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915911</externalid>
        <name>12(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57444</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-400206</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964572</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8979227</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483257</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428157</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957322</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8848584</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74182</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-556833</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-400206</externalid>
    <name>Regulation of lipid metabolism by PPARalpha</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-400206</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340158</externalid>
        <name>SIN3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335898</externalid>
        <name>PPARA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333434</externalid>
        <name>MED1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340182</externalid>
        <name>CHD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340168</externalid>
        <name>CARM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWG1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340176</externalid>
        <name>SMARCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340172</externalid>
        <name>NCOA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BND5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340188</externalid>
        <name>FABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334280</externalid>
        <name>TBL1X</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B7TCI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327530</externalid>
        <name>TGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334284</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-400206</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964572</externalid>
    <name>Lipid particle organization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964572</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400280</externalid>
        <name>FITM2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400115</externalid>
        <name>CIDEA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUX1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400119</externalid>
        <name>CIDEC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400523</externalid>
        <name>HSD17B13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420186</externalid>
        <name>FITM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ11</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964572</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8978868</externalid>
    <name>Fatty acid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8978868</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387829</externalid>
        <name>LOC511425</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386131</externalid>
        <name>DNAL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327868</externalid>
        <name>HSD17B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RUH3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364207</externalid>
        <name>FADS1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MRF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322829</externalid>
        <name>NDUFAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334142</externalid>
        <name>DPEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400487</externalid>
        <name>CBR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386574</externalid>
        <name>SCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TT94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339085</externalid>
        <name>ALDH3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339257</externalid>
        <name>ACAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317380</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330016</externalid>
        <name>CPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397980</externalid>
        <name>SCD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9913892</externalid>
        <name>2-hydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914021</externalid>
        <name>(R)-4,8-dimethylnonanoylcarnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2046043</externalid>
        <name>(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63543</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914140</externalid>
        <name>4-saturated-trans-3-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915899</externalid>
        <name>5-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913887</externalid>
        <name>2-hydroxyphytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915650</externalid>
        <name>11-epi-prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33991</externalid>
        <name>O-palmitoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395901</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045964</externalid>
        <name>(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6811611</externalid>
        <name>pristanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914035</externalid>
        <name>3-oxopristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782159</externalid>
        <name>2-methylpentadec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37143</externalid>
        <name>(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085431</externalid>
        <name>ferricytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914124</externalid>
        <name>S-acyl-4'-phosphopantetheine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913882</externalid>
        <name>2-oxohexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914043</externalid>
        <name>(E)-2,3-didehydropristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915969</externalid>
        <name>(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>389633</externalid>
        <name>pristanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915917</externalid>
        <name>12(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914122</externalid>
        <name>cis-3-octenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760972</externalid>
        <name>3-oxooctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865940</externalid>
        <name>3-hydroxyoctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34859</externalid>
        <name>all-cis-icosa-8,11,14-trienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865932</externalid>
        <name>O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395905</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65131</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045959</externalid>
        <name>(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915837</externalid>
        <name>12(S)-HHTrE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865933</externalid>
        <name>(R)-3-hydroxyacyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760979</externalid>
        <name>3-oxodocosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8932800</externalid>
        <name>meadowlactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915975</externalid>
        <name>(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913884</externalid>
        <name>formyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166601</externalid>
        <name>trans-dec-3-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865943</externalid>
        <name>O-[S-(3R)-3-hydroxyacylpantetheine-4'-phosphoryl]serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914033</externalid>
        <name>4,8,12-trimethyltridecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045968</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045962</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915870</externalid>
        <name>20-oxoleukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>77356</externalid>
        <name>3-oxo-fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15489</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914118</externalid>
        <name>hexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916001</externalid>
        <name>20-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913867</externalid>
        <name>phytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57391</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914048</externalid>
        <name>O-propanoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045961</externalid>
        <name>(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34065</externalid>
        <name>gamma-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15508</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32647</externalid>
        <name>linoleoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915891</externalid>
        <name>12(R)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914018</externalid>
        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327668</externalid>
        <name>3-hydroxypristanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782158</externalid>
        <name>2-methylpentadecenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045963</externalid>
        <name>alpha-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>51985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865938</externalid>
        <name>(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865947</externalid>
        <name>trans-2-octadecenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166589</externalid>
        <name>cis-dec-4-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760985</externalid>
        <name>3-oxohexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73980</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915967</externalid>
        <name>(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971091</externalid>
        <name>O-lauroyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77086</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915976</externalid>
        <name>16-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142812</externalid>
        <name>5,6-DHET</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760741</externalid>
        <name>icosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57380</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31423</externalid>
        <name>(R)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15465</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915995</externalid>
        <name>17-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695975</externalid>
        <name>2,3-dehydrobehenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915909</externalid>
        <name>12-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166604</externalid>
        <name>(2E,4Z)-deca-2,4-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30565</externalid>
        <name>(S)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914137</externalid>
        <name>(R)-3-hydroxyhexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045960</externalid>
        <name>(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914135</externalid>
        <name>trans-2-hexacosenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914133</externalid>
        <name>trans,trans-2,4-dienoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085422</externalid>
        <name>ferrocytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915898</externalid>
        <name>hepoxilin B3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913889</externalid>
        <name>(2S)-pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161607</externalid>
        <name>malonaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>566274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045965</externalid>
        <name>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762310</externalid>
        <name>stearoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57394</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142681</externalid>
        <name>eoxin C4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63984</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37145</externalid>
        <name>(3Z,6Z)-dodecadienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395906</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915895</externalid>
        <name>eoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914041</externalid>
        <name>4,8-dimethylnonanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915863</externalid>
        <name>20-hydroxy-20-oxoleukotriene B4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395904</externalid>
        <name>(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760974</externalid>
        <name>tetracosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865942</externalid>
        <name>2,3-trans-enoyl CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695948</externalid>
        <name>docosanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9949575</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865941</externalid>
        <name>oleoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915911</externalid>
        <name>12(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57444</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-75105</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2046104</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-200425</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77289</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390918</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8978868</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75105</externalid>
    <name>Fatty acyl-CoA biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75105</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327872</externalid>
        <name>HSD17B12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386182</externalid>
        <name>PPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346652</externalid>
        <name>TECRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317352</externalid>
        <name>ACLY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327868</externalid>
        <name>HSD17B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RUH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346631</externalid>
        <name>ELOVL7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317359</externalid>
        <name>MORC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330217</externalid>
        <name>ACSL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346618</externalid>
        <name>ELOVL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346627</externalid>
        <name>ELOVL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386567</externalid>
        <name>PPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330205</externalid>
        <name>ACSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383766</externalid>
        <name>HACD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330213</externalid>
        <name>ACSL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346610</externalid>
        <name>ELOVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400491</externalid>
        <name>HKE6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383770</externalid>
        <name>HACD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346648</externalid>
        <name>TECR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343313</externalid>
        <name>ACSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317429</externalid>
        <name>FASN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N647</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400487</externalid>
        <name>CBR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383778</externalid>
        <name>HACD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386574</externalid>
        <name>SCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TT94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383774</externalid>
        <name>HACD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317380</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387850</externalid>
        <name>ACSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397980</externalid>
        <name>SCD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760979</externalid>
        <name>3-oxodocosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760972</externalid>
        <name>3-oxooctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865947</externalid>
        <name>trans-2-octadecenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865940</externalid>
        <name>3-hydroxyoctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865932</externalid>
        <name>O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085422</externalid>
        <name>ferrocytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865942</externalid>
        <name>2,3-trans-enoyl CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4085431</externalid>
        <name>ferricytochrome b5</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18097</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865943</externalid>
        <name>O-[S-(3R)-3-hydroxyacylpantetheine-4'-phosphoryl]serine(1-) residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760741</externalid>
        <name>icosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57380</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865933</externalid>
        <name>(R)-3-hydroxyacyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865938</externalid>
        <name>(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762310</externalid>
        <name>stearoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57394</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865941</externalid>
        <name>oleoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-75876</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-75105</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75876</externalid>
    <name>Synthesis of very long-chain fatty acyl-CoAs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75876</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327872</externalid>
        <name>HSD17B12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346610</externalid>
        <name>ELOVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346652</externalid>
        <name>TECRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383770</externalid>
        <name>HACD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346648</externalid>
        <name>TECR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343313</externalid>
        <name>ACSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327868</externalid>
        <name>HSD17B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RUH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346631</externalid>
        <name>ELOVL7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383778</externalid>
        <name>HACD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330217</externalid>
        <name>ACSL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346618</externalid>
        <name>ELOVL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346627</externalid>
        <name>ELOVL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330205</externalid>
        <name>ACSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383766</externalid>
        <name>HACD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330213</externalid>
        <name>ACSL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383774</externalid>
        <name>HACD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387850</externalid>
        <name>ACSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760979</externalid>
        <name>3-oxodocosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760972</externalid>
        <name>3-oxooctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865947</externalid>
        <name>trans-2-octadecenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865940</externalid>
        <name>3-hydroxyoctadecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865942</externalid>
        <name>2,3-trans-enoyl CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760741</externalid>
        <name>icosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57380</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865938</externalid>
        <name>(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865933</externalid>
        <name>(R)-3-hydroxyacyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762310</externalid>
        <name>stearoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57394</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75876</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142753</externalid>
    <name>Arachidonate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142753</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>FAAH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC506594</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ABCC1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
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          </protein>
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      <gene>
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        <name>LTC4S</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
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      <gene>
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        <name>GPX4</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
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      </gene>
      <gene>
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        <name>LOC132342089</name>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
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      </gene>
      <gene>
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        <name>CYP2C88</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
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      <gene>
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        <name>CYP1A2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ALOX5</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
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          </protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <externalid>G3MZK4</externalid>
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          </protein>
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        <name>PTGIS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
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      <gene>
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        <name>ALOX15B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CYP2C87</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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          </protein>
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      <gene>
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        <name>CYP1A1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
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              <sourcename>UniProt</sourcename>
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        <name>LOC100295883</name>
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          </protein>
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      <gene>
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        <name>LTA4H</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
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          </protein>
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      <gene>
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        <name>CYP2U1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI9</externalid>
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          </protein>
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      <gene>
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        <name>PTGDS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O02853</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>LOC507016</name>
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          <protein>
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              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>LOC527068</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
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          </protein>
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      <gene>
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        <name>HPGDS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ9</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>CYP2C85</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
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          </protein>
        </entity>
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      <gene>
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            </xref>
          </protein>
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      <gene>
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        <name>MAPKAPK2</name>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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        <name>20ALPHA-HSD</name>
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          <protein>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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        <name>GGT1</name>
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              <externalid>G3N2D8</externalid>
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          </protein>
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          </protein>
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              <externalid>Q3SZD7</externalid>
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          </protein>
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              <externalid>F1MNG1</externalid>
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        <name>CYP4B1</name>
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          <protein>
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          </protein>
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          </protein>
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          </protein>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW1</externalid>
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          </protein>
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        <name>DPEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CYP4A22</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>LOC527068</name>
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              <externalid>E1BP71</externalid>
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          </protein>
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      <gene>
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        <name>ALOX5AP</name>
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          <protein>
            <xref>
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              <externalid>Q148F2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388045</externalid>
        <name>AWAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916001</externalid>
        <name>20-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915899</externalid>
        <name>5-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915898</externalid>
        <name>hepoxilin B3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915891</externalid>
        <name>12(R)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915837</externalid>
        <name>12(S)-HHTrE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915650</externalid>
        <name>11-epi-prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
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      <smallmolecule>
        <externalid>2161607</externalid>
        <name>malonaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>566274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
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      <smallmolecule>
        <externalid>2142681</externalid>
        <name>eoxin C4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63984</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8932800</externalid>
        <name>meadowlactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915895</externalid>
        <name>eoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132070</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      <smallmolecule>
        <externalid>9915975</externalid>
        <name>(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84029</externalid>
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      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
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      <smallmolecule>
        <externalid>9915863</externalid>
        <name>20-hydroxy-20-oxoleukotriene B4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90722</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9915967</externalid>
        <name>(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84032</externalid>
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      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
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      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
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      <smallmolecule>
        <externalid>9915976</externalid>
        <name>16-HETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>132019</externalid>
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      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
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      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
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      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
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      <smallmolecule>
        <externalid>2142812</externalid>
        <name>5,6-DHET</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>63974</externalid>
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      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
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      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
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      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915969</externalid>
        <name>(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>84031</externalid>
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        <externalid>9915995</externalid>
        <name>17-HETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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        <externalid>114732</externalid>
        <name>NADPH</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915909</externalid>
        <name>12-oxo-ETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915917</externalid>
        <name>12(R)-HETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915870</externalid>
        <name>20-oxoleukotriene B4(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>90720</externalid>
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      <smallmolecule>
        <externalid>9915911</externalid>
        <name>12(S)-HPETE(1-)</name>
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          <sourcename>ChEBI</sourcename>
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        <externalid>R-BTA-2162123</externalid>
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      <linkedsystem>
        <externalid>R-BTA-2142691</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142816</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142670</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2142753</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2162123</externalid>
    <name>Synthesis of Prostaglandins (PG) and Thromboxanes (TX)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2162123</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365742</externalid>
        <name>CBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333957</externalid>
        <name>PTGES2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365735</externalid>
        <name>PTGDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02853</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325655</externalid>
        <name>HPGDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365749</externalid>
        <name>PTGES</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95L14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317887</externalid>
        <name>PTGIS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317894</externalid>
        <name>TBXAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320691</externalid>
        <name>PTGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915837</externalid>
        <name>12(S)-HHTrE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915650</externalid>
        <name>11-epi-prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161607</externalid>
        <name>malonaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>566274</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2162123</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142691</externalid>
    <name>Synthesis of Leukotrienes (LT) and Eoxins (EX)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142691</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334142</externalid>
        <name>DPEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333970</externalid>
        <name>ALOX5AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334148</externalid>
        <name>DPEP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334159</externalid>
        <name>GGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915895</externalid>
        <name>eoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132070</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915863</externalid>
        <name>20-hydroxy-20-oxoleukotriene B4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915870</externalid>
        <name>20-oxoleukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142681</externalid>
        <name>eoxin C4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63984</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142691</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142688</externalid>
    <name>Synthesis of 5-eicosatetraenoic acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142688</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10403451</externalid>
        <name>PON3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333970</externalid>
        <name>ALOX5AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403439</externalid>
        <name>PON1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403445</externalid>
        <name>PON2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8932800</externalid>
        <name>meadowlactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915899</externalid>
        <name>5-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142688</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142770</externalid>
    <name>Synthesis of 15-eicosatetraenoic acid derivatives</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142770</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365879</externalid>
        <name>ALOX15B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142770</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142712</externalid>
    <name>Synthesis of 12-eicosatetraenoic acid derivatives</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142712</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10404944</externalid>
        <name>ALOXE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314176</externalid>
        <name>GPX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00435</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365826</externalid>
        <name>ALOX12B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915891</externalid>
        <name>12(R)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915909</externalid>
        <name>12-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915917</externalid>
        <name>12(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915911</externalid>
        <name>12(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57444</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142712</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142696</externalid>
    <name>Synthesis of Hepoxilins (HX) and Trioxilins (TrX)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142696</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915915</externalid>
        <name>hepoxilin A3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915898</externalid>
        <name>hepoxilin B3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142696</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142816</externalid>
    <name>Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142816</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333193</externalid>
        <name>CYP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333203</externalid>
        <name>CYP2U1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915976</externalid>
        <name>16-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915995</externalid>
        <name>17-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916001</externalid>
        <name>20-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142816</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142670</externalid>
    <name>Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142670</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333193</externalid>
        <name>CYP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365857</externalid>
        <name>EPHX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QS88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317782</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142812</externalid>
        <name>5,6-DHET</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915969</externalid>
        <name>(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915975</externalid>
        <name>(5Z,8Z,11Z)-14,15-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915967</externalid>
        <name>(5Z,11Z,14Z)-8,9-dihydroxyicosatrienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84032</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142670</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2142753</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2046104</externalid>
    <name>alpha-linolenic (omega3) and linoleic (omega6) acid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2046104</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339268</externalid>
        <name>ACOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346610</externalid>
        <name>ELOVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338704</externalid>
        <name>ABCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346618</externalid>
        <name>ELOVL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330205</externalid>
        <name>ACSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364207</externalid>
        <name>FADS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339257</externalid>
        <name>ACAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364190</externalid>
        <name>FADS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395906</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34859</externalid>
        <name>all-cis-icosa-8,11,14-trienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2046043</externalid>
        <name>(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63543</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045960</externalid>
        <name>(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045961</externalid>
        <name>(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34065</externalid>
        <name>gamma-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15508</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395904</externalid>
        <name>(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395905</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65131</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32647</externalid>
        <name>linoleoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045959</externalid>
        <name>(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9949575</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045963</externalid>
        <name>alpha-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>51985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395901</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045968</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045964</externalid>
        <name>(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045965</externalid>
        <name>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045962</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2046106</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2046105</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2046104</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2046106</externalid>
    <name>alpha-linolenic acid (ALA) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2046106</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339268</externalid>
        <name>ACOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346610</externalid>
        <name>ELOVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338704</externalid>
        <name>ABCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346618</externalid>
        <name>ELOVL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330205</externalid>
        <name>ACSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364207</externalid>
        <name>FADS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339257</externalid>
        <name>ACAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364190</externalid>
        <name>FADS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395906</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2046043</externalid>
        <name>(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63543</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045961</externalid>
        <name>(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395904</externalid>
        <name>(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395905</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65131</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045959</externalid>
        <name>(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045963</externalid>
        <name>alpha-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>51985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045968</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395901</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045965</externalid>
        <name>(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045962</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2046106</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2046104</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2046105</externalid>
    <name>Linoleic acid (LA) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2046105</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346610</externalid>
        <name>ELOVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346614</externalid>
        <name>ELOVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338704</externalid>
        <name>ABCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346618</externalid>
        <name>ELOVL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330205</externalid>
        <name>ACSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364207</externalid>
        <name>FADS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364190</externalid>
        <name>FADS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32647</externalid>
        <name>linoleoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34859</externalid>
        <name>all-cis-icosa-8,11,14-trienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9949575</externalid>
        <name>(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045960</externalid>
        <name>(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2045964</externalid>
        <name>(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34065</externalid>
        <name>gamma-linolenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15508</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2046105</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2046104</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-200425</externalid>
    <name>Carnitine shuttle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-200425</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323248</externalid>
        <name>SLC22A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330092</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323007</externalid>
        <name>PRKAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418896</externalid>
        <name>CPT1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317394</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330113</externalid>
        <name>SLC25A20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330000</externalid>
        <name>CPT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317390</externalid>
        <name>MID1IP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330016</externalid>
        <name>CPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317380</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330005</externalid>
        <name>PPARD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914018</externalid>
        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33991</externalid>
        <name>O-palmitoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17490</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971091</externalid>
        <name>O-lauroyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77086</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-200425</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77289</externalid>
    <name>Mitochondrial Fatty Acid Beta-Oxidation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77289</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10398139</externalid>
        <name>DBI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386189</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387829</externalid>
        <name>LOC511425</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398143</externalid>
        <name>ACBD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318422</externalid>
        <name>ECI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398168</externalid>
        <name>ACBD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403519</externalid>
        <name>MCAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386150</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313672</externalid>
        <name>MMAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386175</externalid>
        <name>PCTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386197</externalid>
        <name>ACOT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318077</externalid>
        <name>ACADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386146</externalid>
        <name>ACOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386160</externalid>
        <name>ACOT13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QGE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387836</externalid>
        <name>ACAD11</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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              <externalid>E1BNW7</externalid>
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          </protein>
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      <gene>
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        <name>PCCA</name>
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              <externalid>A0A3Q1N969</externalid>
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          </protein>
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      <gene>
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        <name>HADHB</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DECR1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNW7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MUT</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0III1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MECR</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MEY2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACADVL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48818</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THEM5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAC0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDUFAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACADL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08D92</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387843</externalid>
        <name>ACSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318054</externalid>
        <name>ACADS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402462</externalid>
        <name>ACAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313693</externalid>
        <name>MCEE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30565</externalid>
        <name>(S)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>77356</externalid>
        <name>3-oxo-fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15489</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782158</externalid>
        <name>2-methylpentadecenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37145</externalid>
        <name>(3Z,6Z)-dodecadienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166589</externalid>
        <name>cis-dec-4-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6782159</externalid>
        <name>2-methylpentadec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166601</externalid>
        <name>trans-dec-3-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37143</externalid>
        <name>(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695948</externalid>
        <name>docosanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31423</externalid>
        <name>(R)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15465</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695975</externalid>
        <name>2,3-dehydrobehenoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166604</externalid>
        <name>(2E,4Z)-deca-2,4-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29119</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77288</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71032</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-77289</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77286</externalid>
    <name>mitochondrial fatty acid beta-oxidation of saturated fatty acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77286</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318003</externalid>
        <name>ACADL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08D92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318054</externalid>
        <name>ACADS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406846</externalid>
        <name>MECR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318033</externalid>
        <name>ACADVL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48818</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318077</externalid>
        <name>ACADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-77305</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77285</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77310</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77346</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77348</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77350</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77352</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-77286</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77289</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77305</externalid>
    <name>Beta oxidation of palmitoyl-CoA to myristoyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77305</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318033</externalid>
        <name>ACADVL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48818</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37107</externalid>
        <name>(S)-3-hydroxypalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760914</externalid>
        <name>(E)-hexadec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37109</externalid>
        <name>3-oxopalmitoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77305</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77285</externalid>
    <name>Beta oxidation of myristoyl-CoA to lauroyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77285</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318003</externalid>
        <name>ACADL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08D92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37135</externalid>
        <name>trans-tetradec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37111</externalid>
        <name>(S)-3-hydroxytetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114932</externalid>
        <name>3-oxotetradecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28726</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77285</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77310</externalid>
    <name>Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77310</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318003</externalid>
        <name>ACADL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08D92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37113</externalid>
        <name>(S)-3-hydroxylauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27668</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760748</externalid>
        <name>trans-dodec-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760755</externalid>
        <name>lauroyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37115</externalid>
        <name>3-oxolauroyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77310</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77346</externalid>
    <name>Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77346</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406846</externalid>
        <name>MECR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318077</externalid>
        <name>ACADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37119</externalid>
        <name>3-oxodecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37137</externalid>
        <name>decanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37117</externalid>
        <name>(S)-3-hydroxydecanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77346</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77348</externalid>
    <name>Beta oxidation of octanoyl-CoA to hexanoyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77348</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318077</externalid>
        <name>ACADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>32491</externalid>
        <name>octanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37123</externalid>
        <name>3-oxooctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37121</externalid>
        <name>(S)-3-hydroxyoctanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77348</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77350</externalid>
    <name>Beta oxidation of hexanoyl-CoA to butanoyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77350</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318054</externalid>
        <name>ACADS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760907</externalid>
        <name>trans-hex-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37127</externalid>
        <name>3-oxohexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37125</externalid>
        <name>(S)-3-hydroxyhexanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760904</externalid>
        <name>hexanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62620</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77350</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77352</externalid>
    <name>Beta oxidation of butanoyl-CoA to acetyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77352</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318054</externalid>
        <name>ACADS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31305</externalid>
        <name>(S)-3-hydroxybutanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762302</externalid>
        <name>butyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77352</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77286</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77288</externalid>
    <name>mitochondrial fatty acid beta-oxidation of unsaturated fatty acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77288</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318433</externalid>
        <name>DECR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318422</externalid>
        <name>ECI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318077</externalid>
        <name>ACADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>166601</externalid>
        <name>trans-dec-3-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37143</externalid>
        <name>(2-trans,6-cis)-dodeca-2,6-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166589</externalid>
        <name>cis-dec-4-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37145</externalid>
        <name>(3Z,6Z)-dodecadienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37139</externalid>
        <name>trans-dec-2-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166604</externalid>
        <name>(2E,4Z)-deca-2,4-dienoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29119</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77288</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77289</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71032</externalid>
    <name>Propionyl-CoA catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71032</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313700</externalid>
        <name>PCCA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313678</externalid>
        <name>MUT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313672</externalid>
        <name>MMAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313693</externalid>
        <name>MCEE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30565</externalid>
        <name>(S)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31423</externalid>
        <name>(R)-methylmalonyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15465</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-71032</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77289</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390918</externalid>
    <name>Peroxisomal lipid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390918</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339268</externalid>
        <name>ACOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389795</externalid>
        <name>HAO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398153</externalid>
        <name>ACBD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386131</externalid>
        <name>DNAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339239</externalid>
        <name>ACOX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396043</externalid>
        <name>EHHADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <smallmolecule>
        <externalid>9913892</externalid>
        <name>2-hydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65097</externalid>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9914118</externalid>
        <name>hexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914137</externalid>
        <name>(R)-3-hydroxyhexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9914021</externalid>
        <name>(R)-4,8-dimethylnonanoylcarnitine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>84654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914140</externalid>
        <name>4-saturated-trans-3-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85493</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9913867</externalid>
        <name>phytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57391</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9914048</externalid>
        <name>O-propanoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53210</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>9914135</externalid>
        <name>trans-2-hexacosenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74281</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914133</externalid>
        <name>trans,trans-2,4-dienoyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>85101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913887</externalid>
        <name>2-hydroxyphytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57334</externalid>
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      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
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      <smallmolecule>
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        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
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      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
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      <smallmolecule>
        <externalid>9913889</externalid>
        <name>(2S)-pristanoyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77099</externalid>
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      <smallmolecule>
        <externalid>2327668</externalid>
        <name>3-hydroxypristanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
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      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9914041</externalid>
        <name>4,8-dimethylnonanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914035</externalid>
        <name>3-oxopristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57291</externalid>
        </xref>
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      <smallmolecule>
        <externalid>6811611</externalid>
        <name>pristanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77268</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
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      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760985</externalid>
        <name>3-oxohexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73980</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913884</externalid>
        <name>formyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
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      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      <smallmolecule>
        <externalid>9760974</externalid>
        <name>tetracosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65052</externalid>
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      <smallmolecule>
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        <name>S-acyl-4'-phosphopantetheine(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>132023</externalid>
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      <smallmolecule>
        <externalid>9914033</externalid>
        <name>4,8,12-trimethyltridecanoyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57351</externalid>
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      <smallmolecule>
        <externalid>9913882</externalid>
        <name>2-oxohexadecanoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>176593</externalid>
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      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914043</externalid>
        <name>(E)-2,3-didehydropristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77293</externalid>
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      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>389633</externalid>
        <name>pristanal</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>49189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914122</externalid>
        <name>cis-3-octenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85640</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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        <externalid>R-BTA-389599</externalid>
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        <externalid>R-HSA-390918</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978868</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-389599</externalid>
    <name>Alpha-oxidation of phytanate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-389599</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339122</externalid>
        <name>SLC25A17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339113</externalid>
        <name>PHYH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18778</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396892</externalid>
        <name>PECR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339085</externalid>
        <name>ALDH3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339094</externalid>
        <name>HACL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9913887</externalid>
        <name>2-hydroxyphytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57334</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6811611</externalid>
        <name>pristanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>389633</externalid>
        <name>pristanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913867</externalid>
        <name>phytanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57391</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913884</externalid>
        <name>formyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-389599</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390918</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-389887</externalid>
    <name>Beta-oxidation of pristanoyl-CoA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-389887</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339279</externalid>
        <name>CROT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19094</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339228</externalid>
        <name>ACOXL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339286</externalid>
        <name>CRAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327698</externalid>
        <name>AMACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339239</externalid>
        <name>ACOX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327745</externalid>
        <name>ACOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914041</externalid>
        <name>4,8-dimethylnonanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914033</externalid>
        <name>4,8,12-trimethyltridecanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914035</externalid>
        <name>3-oxopristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914018</externalid>
        <name>O-acetyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914021</externalid>
        <name>(R)-4,8-dimethylnonanoylcarnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914043</externalid>
        <name>(E)-2,3-didehydropristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913880</externalid>
        <name>pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77250</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913889</externalid>
        <name>(2S)-pristanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77099</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327668</externalid>
        <name>3-hydroxypristanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914048</externalid>
        <name>O-propanoyl-L-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-389887</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390918</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390247</externalid>
    <name>Beta-oxidation of very long chain fatty acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390247</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339268</externalid>
        <name>ACOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351083</externalid>
        <name>MLYCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386135</externalid>
        <name>LOC512541</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338704</externalid>
        <name>ABCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396883</externalid>
        <name>ECI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396043</externalid>
        <name>EHHADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386131</externalid>
        <name>DNAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339257</externalid>
        <name>ACAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914118</externalid>
        <name>hexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914137</externalid>
        <name>(R)-3-hydroxyhexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760750</externalid>
        <name>malonyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914128</externalid>
        <name>trans-oct-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865945</externalid>
        <name>very long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914140</externalid>
        <name>4-saturated-trans-3-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85493</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760985</externalid>
        <name>3-oxohexacosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73980</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914135</externalid>
        <name>trans-2-hexacosenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865935</externalid>
        <name>very long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914133</externalid>
        <name>trans,trans-2,4-dienoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690050</externalid>
        <name>medium-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5690076</externalid>
        <name>medium-chain fatty acyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760974</externalid>
        <name>tetracosanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914122</externalid>
        <name>cis-3-octenoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85640</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390247</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390918</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8979227</externalid>
    <name>Triglyceride metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8979227</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317565</externalid>
        <name>LPIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377827</externalid>
        <name>FABP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55052</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317510</externalid>
        <name>GPAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317514</externalid>
        <name>GPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387909</externalid>
        <name>AGMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393877</externalid>
        <name>MOGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70VZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393881</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377843</externalid>
        <name>FABP12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340188</externalid>
        <name>FABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377835</externalid>
        <name>FABP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q09139</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377831</externalid>
        <name>FABP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DID8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317535</externalid>
        <name>GK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317523</externalid>
        <name>GK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377819</externalid>
        <name>FABP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317529</externalid>
        <name>LOC538702</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317582</externalid>
        <name>DGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317569</externalid>
        <name>LPIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326858</externalid>
        <name>GPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398230</externalid>
        <name>PNPLA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X777</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377815</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377823</externalid>
        <name>FABP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377839</externalid>
        <name>FABP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397778</externalid>
        <name>M6PRBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317573</externalid>
        <name>LPIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696109</externalid>
        <name>alkylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52575</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-75109</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163560</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8979227</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75109</externalid>
    <name>Triglyceride biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75109</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317565</externalid>
        <name>LPIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317510</externalid>
        <name>GPAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317514</externalid>
        <name>GPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317535</externalid>
        <name>GK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317523</externalid>
        <name>GK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387909</externalid>
        <name>AGMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317529</externalid>
        <name>LOC538702</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393877</externalid>
        <name>MOGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70VZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393881</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317582</externalid>
        <name>DGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317569</externalid>
        <name>LPIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317573</externalid>
        <name>LPIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696109</externalid>
        <name>alkylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52575</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75109</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8979227</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163560</externalid>
    <name>Triglyceride catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163560</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10377843</externalid>
        <name>FABP12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377827</externalid>
        <name>FABP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55052</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326858</externalid>
        <name>GPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398230</externalid>
        <name>PNPLA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X777</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377815</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377823</externalid>
        <name>FABP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377819</externalid>
        <name>FABP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340188</externalid>
        <name>FABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377835</externalid>
        <name>FABP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q09139</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377839</externalid>
        <name>FABP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397778</externalid>
        <name>M6PRBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377831</externalid>
        <name>FABP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DID8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163560</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8979227</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483257</externalid>
    <name>Phospholipid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483257</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317514</externalid>
        <name>GPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402415</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402408</externalid>
        <name>TMEM86B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389691</externalid>
        <name>DDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359469</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387875</externalid>
        <name>AGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356691</externalid>
        <name>LPCAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357087</externalid>
        <name>CDS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359299</externalid>
        <name>PIP4K2B</name>
        <entity>
          <protein>
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      <gene>
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        <name>glycerol</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GTP</name>
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      <smallmolecule>
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        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
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      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17476</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1498727</externalid>
        <name>1-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>1164584</externalid>
        <name>1-acylglycerophosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11230</externalid>
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      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
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      <smallmolecule>
        <externalid>8865641</externalid>
        <name>lysophosphatidylcholine 22:6</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>64567</externalid>
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      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5694562</externalid>
        <name>acyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22221</externalid>
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      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5694471</externalid>
        <name>lysophosphatidylcholine 14:0</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64483</externalid>
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      <smallmolecule>
        <externalid>6813741</externalid>
        <name>1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58444</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      <smallmolecule>
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        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>phosphocholines</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
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      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
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      <smallmolecule>
        <externalid>29930</externalid>
        <name>CDP-choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
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      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
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      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      <smallmolecule>
        <externalid>1498745</externalid>
        <name>2-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27923</externalid>
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      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
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      <smallmolecule>
        <externalid>8874449</externalid>
        <name>glycerophosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36313</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
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      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
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      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
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      <smallmolecule>
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        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
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      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874445</externalid>
        <name>glycerophosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498723</externalid>
        <name>2-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694585</externalid>
        <name>N-arachidonoylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874441</externalid>
        <name>1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760848</externalid>
        <name>CDP-ethanolamine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878652</externalid>
        <name>1-myristoyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498776</externalid>
        <name>2-monolysocardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498720</externalid>
        <name>2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498742</externalid>
        <name>2-acyl-sn-glycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694561</externalid>
        <name>N-acylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498741</externalid>
        <name>1-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796685</externalid>
        <name>2,2'-dilysocardiolipin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498744</externalid>
        <name>2-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8934415</externalid>
        <name>1-monomyristoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1483257</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483206</externalid>
    <name>Glycerophospholipid biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483206</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317514</externalid>
        <name>GPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402408</externalid>
        <name>TMEM86B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389691</externalid>
        <name>DDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387875</externalid>
        <name>AGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356691</externalid>
        <name>LPCAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357087</externalid>
        <name>CDS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407044</externalid>
        <name>MIGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNB3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNPAT</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401400</externalid>
        <name>OSBPL10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333810</externalid>
        <name>CHAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357031</externalid>
        <name>PCYT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400335</externalid>
        <name>PLAAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QAQ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356720</externalid>
        <name>CRLS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357015</externalid>
        <name>CHKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387815</externalid>
        <name>ABHD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356966</externalid>
        <name>CEPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317473</externalid>
        <name>AGPAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401654</externalid>
        <name>PITPNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317544</externalid>
        <name>GPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357048</externalid>
        <name>PITPNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TR36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357075</externalid>
        <name>CDS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317493</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407050</externalid>
        <name>MIGA2</name>
        <entity>
          <protein>
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        </entity>
      </gene>
      <gene>
        <externalid>10356784</externalid>
        <name>MBOAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405958</externalid>
        <name>PLA2G15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WMP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357114</externalid>
        <name>PTDSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326858</externalid>
        <name>GPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357094</externalid>
        <name>PEMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357105</externalid>
        <name>PLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401404</externalid>
        <name>OSBPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357009</externalid>
        <name>CHKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8874445</externalid>
        <name>glycerophosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498723</externalid>
        <name>2-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760926</externalid>
        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694585</externalid>
        <name>N-arachidonoylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874441</externalid>
        <name>1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760848</externalid>
        <name>CDP-ethanolamine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874448</externalid>
        <name>1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498727</externalid>
        <name>1-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164584</externalid>
        <name>1-acylglycerophosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8865641</externalid>
        <name>lysophosphatidylcholine 22:6</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694562</externalid>
        <name>acyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22221</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878652</externalid>
        <name>1-myristoyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694471</externalid>
        <name>lysophosphatidylcholine 14:0</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498776</externalid>
        <name>2-monolysocardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498720</externalid>
        <name>2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498721</externalid>
        <name>1-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29930</externalid>
        <name>CDP-choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498742</externalid>
        <name>2-acyl-sn-glycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694561</externalid>
        <name>N-acylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498741</externalid>
        <name>1-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498745</externalid>
        <name>2-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874449</externalid>
        <name>glycerophosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796685</externalid>
        <name>2,2'-dilysocardiolipin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498744</externalid>
        <name>2-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975651</externalid>
        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8934415</externalid>
        <name>1-monomyristoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1483166</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482883</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483213</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482839</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483191</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483196</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482788</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483115</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483101</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482801</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483226</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482922</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483148</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482925</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483076</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1482798</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1483206</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483257</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483166</externalid>
    <name>Synthesis of PA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483166</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317485</externalid>
        <name>AGPAT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7D4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317510</externalid>
        <name>GPAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317514</externalid>
        <name>GPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357101</externalid>
        <name>PLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317493</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407050</externalid>
        <name>MIGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389691</externalid>
        <name>DDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317481</externalid>
        <name>AGPAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317550</externalid>
        <name>GPD1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407044</externalid>
        <name>MIGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317501</externalid>
        <name>LPCAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317443</externalid>
        <name>GNPAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389687</externalid>
        <name>DDHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317497</externalid>
        <name>GPAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407037</externalid>
        <name>PLD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317489</externalid>
        <name>LPCAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403248</externalid>
        <name>ACP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317469</externalid>
        <name>AGPAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326858</externalid>
        <name>GPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357105</externalid>
        <name>PLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317465</externalid>
        <name>AGPAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95JH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317477</externalid>
        <name>AGPAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317473</externalid>
        <name>AGPAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403267</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317544</externalid>
        <name>GPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549106</externalid>
        <name>1-acyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498742</externalid>
        <name>2-acyl-sn-glycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17936</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878652</externalid>
        <name>1-myristoyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8934415</externalid>
        <name>1-monomyristoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317467</externalid>
        <name>phosphate monoester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7794</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483166</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482883</externalid>
    <name>Acyl chain remodeling of DAG and TAG</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482883</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356802</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E554</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341803</externalid>
        <name>MGLL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398302</externalid>
        <name>DGAT2L6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356798</externalid>
        <name>PNPLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5T0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317582</externalid>
        <name>DGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>192472</externalid>
        <name>2-monoglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17389</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482883</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483213</externalid>
    <name>Synthesis of PE</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483213</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317565</externalid>
        <name>LPIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357121</externalid>
        <name>PCYT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388035</externalid>
        <name>ETNPPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356975</externalid>
        <name>SELENOI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357015</externalid>
        <name>CHKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357153</externalid>
        <name>ETNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N378</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357157</externalid>
        <name>ETNK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356966</externalid>
        <name>CEPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357066</externalid>
        <name>PHOSPHO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357009</externalid>
        <name>CHKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317573</externalid>
        <name>LPIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317569</externalid>
        <name>LPIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760848</externalid>
        <name>CDP-ethanolamine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57876</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483213</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482839</externalid>
    <name>Acyl chain remodelling of PE</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482839</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400339</externalid>
        <name>HRASLS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356890</externalid>
        <name>PNPLA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356691</externalid>
        <name>LPCAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317489</externalid>
        <name>LPCAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356769</externalid>
        <name>PLBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GL30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356784</externalid>
        <name>MBOAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358109</externalid>
        <name>PLA2G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400335</externalid>
        <name>PLAAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QAQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387815</externalid>
        <name>ABHD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356914</externalid>
        <name>PLA2G6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694562</externalid>
        <name>acyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22221</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694585</externalid>
        <name>N-arachidonoylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694561</externalid>
        <name>N-acylphosphatidylethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498720</externalid>
        <name>2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28936</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482839</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483191</externalid>
    <name>Synthesis of PC</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483191</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317565</externalid>
        <name>LPIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343753</externalid>
        <name>SLC44A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387759</externalid>
        <name>ABHD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317501</externalid>
        <name>LPCAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356986</externalid>
        <name>CHPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401030</externalid>
        <name>MFSD2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333810</externalid>
        <name>CHAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357031</externalid>
        <name>PCYT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343757</externalid>
        <name>SLC44A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402276</externalid>
        <name>STARD10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386175</externalid>
        <name>PCTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418065</externalid>
        <name>STARD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343761</externalid>
        <name>SLC44A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317569</externalid>
        <name>LPIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357037</externalid>
        <name>PCYT1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343749</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357015</externalid>
        <name>CHKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357094</externalid>
        <name>PEMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356966</externalid>
        <name>CEPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357066</externalid>
        <name>PHOSPHO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317573</externalid>
        <name>LPIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357009</externalid>
        <name>CHKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343765</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5M4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29930</externalid>
        <name>CDP-choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164584</externalid>
        <name>1-acylglycerophosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11230</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8865641</externalid>
        <name>lysophosphatidylcholine 22:6</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694471</externalid>
        <name>lysophosphatidylcholine 14:0</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483191</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483196</externalid>
    <name>PI and PC transport between ER and Golgi membranes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483196</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357048</externalid>
        <name>PITPNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TR36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483196</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482788</externalid>
    <name>Acyl chain remodelling of PC</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482788</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356687</externalid>
        <name>LPCAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402408</externalid>
        <name>TMEM86B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356890</externalid>
        <name>PNPLA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356691</externalid>
        <name>LPCAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317501</externalid>
        <name>LPCAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317489</externalid>
        <name>LPCAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356769</externalid>
        <name>PLBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GL30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358109</externalid>
        <name>PLA2G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350832</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356914</externalid>
        <name>PLA2G6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8874445</externalid>
        <name>glycerophosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874449</externalid>
        <name>glycerophosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874441</externalid>
        <name>1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8874448</externalid>
        <name>1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975651</externalid>
        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164237</externalid>
        <name>fatty aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35746</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482788</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483115</externalid>
    <name>Hydrolysis of LPC</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483115</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10405958</externalid>
        <name>PLA2G15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WMP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356769</externalid>
        <name>PLBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GL30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>975651</externalid>
        <name>2-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16728</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483115</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483101</externalid>
    <name>Synthesis of PS</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483101</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357114</externalid>
        <name>PTDSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357059</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483101</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482801</externalid>
    <name>Acyl chain remodelling of PS</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482801</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356784</externalid>
        <name>MBOAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356691</externalid>
        <name>LPCAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401400</externalid>
        <name>OSBPL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401404</externalid>
        <name>OSBPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317489</externalid>
        <name>LPCAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401408</externalid>
        <name>OSBPL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498727</externalid>
        <name>1-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498744</externalid>
        <name>2-acyl-sn-glycero-3-phosphoserine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37646</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482801</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483226</externalid>
    <name>Synthesis of PI</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483226</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357075</externalid>
        <name>CDS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356995</externalid>
        <name>CDIPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401662</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N293</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401654</externalid>
        <name>PITPNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401658</externalid>
        <name>PITPNM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760926</externalid>
        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483226</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482922</externalid>
    <name>Acyl chain remodelling of PI</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482922</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356735</externalid>
        <name>MBOAT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356761</externalid>
        <name>PLA2G4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356769</externalid>
        <name>PLBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GL30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498723</externalid>
        <name>2-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498721</externalid>
        <name>1-acyl-sn-glycero-3-phospho-D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28914</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482922</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483148</externalid>
    <name>Synthesis of PG</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483148</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357087</externalid>
        <name>CDS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760926</externalid>
        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483148</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482925</externalid>
    <name>Acyl chain remodelling of PG</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482925</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356744</externalid>
        <name>PLA2G4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356752</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356748</externalid>
        <name>PLA2G4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358109</externalid>
        <name>PLA2G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358099</externalid>
        <name>PLA2G2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358115</externalid>
        <name>PLA2G5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317501</externalid>
        <name>LPCAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358127</externalid>
        <name>PLA2G12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358093</externalid>
        <name>PLA2G2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356720</externalid>
        <name>CRLS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358083</externalid>
        <name>PLA2G1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317489</externalid>
        <name>LPCAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358121</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356704</externalid>
        <name>LPGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358136</externalid>
        <name>PLA2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49259</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356765</externalid>
        <name>PLA2G4F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1498741</externalid>
        <name>1-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498745</externalid>
        <name>2-acyl-sn-glycero-3-phosphoglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482925</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483076</externalid>
    <name>Synthesis of CL</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483076</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356720</externalid>
        <name>CRLS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760926</externalid>
        <name>CDP-diacylglycerol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483076</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1482798</externalid>
    <name>Acyl chain remodeling of CL</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1482798</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317493</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356877</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318016</externalid>
        <name>HADHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46629</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318012</externalid>
        <name>HADHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498726</externalid>
        <name>1-acyl-sn-glycero-3-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1498776</externalid>
        <name>2-monolysocardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796685</externalid>
        <name>2,2'-dilysocardiolipin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75137</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1482798</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483255</externalid>
    <name>PI Metabolism</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483255</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10359478</externalid>
        <name>FIG4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402415</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359469</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ59</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359394</externalid>
        <name>PI4KB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXI3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359299</externalid>
        <name>PIP4K2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401771</externalid>
        <name>PLEKHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359343</externalid>
        <name>MTMR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397963</externalid>
        <name>ENPP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401765</externalid>
        <name>PTPN13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359322</externalid>
        <name>PI4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397497</externalid>
        <name>GDE1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3T0T0</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>LOC516736</name>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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        <name>manganese(2+)</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9760917</externalid>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6813741</externalid>
        <name>1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58444</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1483248</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483196</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660514</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660499</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660516</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6814848</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8847453</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1483255</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483257</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1483248</externalid>
    <name>Synthesis of PIPs at the ER membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1483248</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359557</externalid>
        <name>SACM1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359339</externalid>
        <name>MTMR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359326</externalid>
        <name>PI4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396868</externalid>
        <name>SBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359361</externalid>
        <name>PI4KA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676006</externalid>
        <name>phosphatidylinositol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1483248</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660514</externalid>
    <name>Synthesis of PIPs at the Golgi membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660514</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359478</externalid>
        <name>FIG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359394</externalid>
        <name>PI4KB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359400</externalid>
        <name>ARF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359482</externalid>
        <name>VAC14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359361</externalid>
        <name>PI4KA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359486</externalid>
        <name>PIKFYVE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359557</externalid>
        <name>SACM1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359326</externalid>
        <name>PI4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359417</externalid>
        <name>PIK3C2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359322</externalid>
        <name>PI4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359372</externalid>
        <name>INPP5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334430</externalid>
        <name>ARF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359632</externalid>
        <name>LOC516736</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1660514</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660499</externalid>
    <name>Synthesis of PIPs at the plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660499</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359469</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359299</externalid>
        <name>PIP4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401771</externalid>
        <name>PLEKHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401765</externalid>
        <name>PTPN13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359322</externalid>
        <name>PI4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402172</externalid>
        <name>PLEKHA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348130</externalid>
        <name>INPPL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359335</externalid>
        <name>MTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399837</externalid>
        <name>RAB4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396030</externalid>
        <name>MTMR8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402176</externalid>
        <name>PLEKHA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359591</externalid>
        <name>INPP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B820</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359595</externalid>
        <name>INPP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402161</externalid>
        <name>PLEKHA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M501</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359293</externalid>
        <name>PIP4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402235</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R352</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401761</externalid>
        <name>PLEKHA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359465</externalid>
        <name>MTMR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396034</externalid>
        <name>MTMR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359284</externalid>
        <name>PIP5K1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359441</externalid>
        <name>INPP5J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329812</externalid>
        <name>PTEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359457</externalid>
        <name>MTMR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334506</externalid>
        <name>BMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359417</externalid>
        <name>PIK3C2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402153</externalid>
        <name>PLEKHA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7V8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402157</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359461</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338945</externalid>
        <name>PIK3R6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359385</externalid>
        <name>SYNJ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359546</externalid>
        <name>PIK3C2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339934</externalid>
        <name>PIP5K1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359280</externalid>
        <name>PIP5K1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353112</externalid>
        <name>RAB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338953</externalid>
        <name>PIK3CD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359307</externalid>
        <name>PIP4K2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391924</externalid>
        <name>RAB14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359437</externalid>
        <name>INPP5K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359326</externalid>
        <name>PI4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334430</externalid>
        <name>ARF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1660499</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660516</externalid>
    <name>Synthesis of PIPs at the early endosome membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660516</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359478</externalid>
        <name>FIG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359339</externalid>
        <name>MTMR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359335</externalid>
        <name>MTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359343</externalid>
        <name>MTMR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359482</externalid>
        <name>VAC14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359486</externalid>
        <name>PIKFYVE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396852</externalid>
        <name>MTMR12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359326</externalid>
        <name>PI4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398722</externalid>
        <name>INPP5F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359322</externalid>
        <name>PI4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359591</externalid>
        <name>INPP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B820</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359595</externalid>
        <name>INPP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1660516</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660517</externalid>
    <name>Synthesis of PIPs at the late endosome membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359478</externalid>
        <name>FIG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359486</externalid>
        <name>PIKFYVE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359339</externalid>
        <name>MTMR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359335</externalid>
        <name>MTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359347</externalid>
        <name>MTMR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359343</externalid>
        <name>MTMR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359482</externalid>
        <name>VAC14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1660517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6814848</externalid>
    <name>Glycerophospholipid catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6814848</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10397963</externalid>
        <name>ENPP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397497</externalid>
        <name>GDE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397575</externalid>
        <name>PNPLA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760786</externalid>
        <name>sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30541</externalid>
        <name>choline alfoscerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16870</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6813741</externalid>
        <name>1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58444</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317224</externalid>
        <name>monoacylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17408</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6814848</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8847453</externalid>
    <name>Synthesis of PIPs in the nucleus</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8847453</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359307</externalid>
        <name>PIP4K2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359293</externalid>
        <name>PIP4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359299</externalid>
        <name>PIP4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396978</externalid>
        <name>PIP4P1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8847453</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1483255</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-428157</externalid>
    <name>Sphingolipid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-428157</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358949</externalid>
        <name>UGCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DR4</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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      <gene>
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        <name>GBA1</name>
        <entity>
          <protein>
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              <externalid>F1N1D5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPTLC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342196</externalid>
        <name>ORMDL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342610</externalid>
        <name>SGMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF31</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389471</externalid>
        <name>UGT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358478</externalid>
        <name>SMPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFH4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412920</externalid>
        <name>MFSD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417874</externalid>
        <name>A4GALT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342540</externalid>
        <name>PRKD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358518</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410582</externalid>
        <name>B3GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412916</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358600</externalid>
        <name>ARSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342601</externalid>
        <name>SGMS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342192</externalid>
        <name>ORMDL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342576</externalid>
        <name>VAPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342270</externalid>
        <name>ACER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342353</externalid>
        <name>PLPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342221</externalid>
        <name>CERS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358317</externalid>
        <name>GM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339085</externalid>
        <name>ALDH3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342357</externalid>
        <name>PLPP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401461</externalid>
        <name>OSBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9840994</externalid>
        <name>choline phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>295975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843874</externalid>
        <name>phytosphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843243</externalid>
        <name>N-hexadecanoylsphinganine-1-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846303</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78569</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605734</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760814</externalid>
        <name>sphingosine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57756</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840473</externalid>
        <name>1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840463</externalid>
        <name>PE(16:1(9Z)/16:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605616</externalid>
        <name>N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317270</externalid>
        <name>sphingoid 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>428282</externalid>
        <name>trans-hexadec-2-enal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840849</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845542</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840469</externalid>
        <name>PE(18:0/16:1(9Z)) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842381</externalid>
        <name>(4E)-unsatiated ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842019</externalid>
        <name>(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845579</externalid>
        <name>ganglioside GD3(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846338</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843245</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29998</externalid>
        <name>O-phosphoethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17553</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840447</externalid>
        <name>PE(16:1(9Z)/14:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841056</externalid>
        <name>sphingomyelin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844864</externalid>
        <name>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5228369</externalid>
        <name>alpha-Neu5NAc-(2-&gt;8)-alpha-Neu5NAc-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845603</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNac-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87787</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841796</externalid>
        <name>3-dehydrosphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843200</externalid>
        <name>(2R)-2-hydroxy fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845590</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844848</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843244</externalid>
        <name>N-hexadecanoylsphinganine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843204</externalid>
        <name>2-saturated fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1660672</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844852</externalid>
        <name>ganglioside GM2 (18:0) (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316542</externalid>
        <name>N-acylphytosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30291</externalid>
        <name>hexadecanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842386</externalid>
        <name>phytoceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429777</externalid>
        <name>sphingomyelin d18:1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845501</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5250592</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840626</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844857</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845517</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846339</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845499</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841183</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842378</externalid>
        <name>dihydroceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841240</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844331</externalid>
        <name>sphinganine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840845</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;3)-alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317273</externalid>
        <name>sphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840456</externalid>
        <name>1-oleoyl-2-palmitoleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36715</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide(d18:1(4E))</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17103</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1660661</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660662</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9845614</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-428157</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660661</externalid>
    <name>Sphingolipid de novo biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660661</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342196</externalid>
        <name>ORMDL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342610</externalid>
        <name>SGMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342548</externalid>
        <name>PRKD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412929</externalid>
        <name>SPHK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412920</externalid>
        <name>MFSD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342256</externalid>
        <name>DEGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBY7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387345</externalid>
        <name>FA2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407302</externalid>
        <name>SAMD8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIC5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342225</externalid>
        <name>CERS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342149</externalid>
        <name>KDSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342248</externalid>
        <name>CYB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342561</externalid>
        <name>CSNK1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342170</externalid>
        <name>SPTSSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIK4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342263</externalid>
        <name>DEGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342568</externalid>
        <name>PPM1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342178</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342544</externalid>
        <name>PRKD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342540</externalid>
        <name>PRKD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWF5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412916</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342533</externalid>
        <name>CERT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GKI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342601</externalid>
        <name>SGMS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342192</externalid>
        <name>ORMDL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342209</externalid>
        <name>CERS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342205</externalid>
        <name>LASS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342161</externalid>
        <name>SPTLC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342188</externalid>
        <name>ORMDL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342166</externalid>
        <name>SPTSSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E978</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342576</externalid>
        <name>VAPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342156</externalid>
        <name>SPTLC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342221</externalid>
        <name>CERS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342217</externalid>
        <name>CERS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342213</externalid>
        <name>LASS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401461</externalid>
        <name>OSBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342572</externalid>
        <name>VAPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841796</externalid>
        <name>3-dehydrosphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843200</externalid>
        <name>(2R)-2-hydroxy fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842381</externalid>
        <name>(4E)-unsatiated ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843243</externalid>
        <name>N-hexadecanoylsphinganine-1-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843244</externalid>
        <name>N-hexadecanoylsphinganine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843204</externalid>
        <name>2-saturated fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842378</externalid>
        <name>dihydroceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842386</externalid>
        <name>phytoceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9843245</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317273</externalid>
        <name>sphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841056</externalid>
        <name>sphingomyelin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317270</externalid>
        <name>sphingoid 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1660661</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428157</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1660662</externalid>
    <name>Glycosphingolipid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1660662</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358949</externalid>
        <name>UGCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358487</externalid>
        <name>SMPD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358409</externalid>
        <name>NEU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358443</externalid>
        <name>GLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B725</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374244</externalid>
        <name>ST6GALNAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358432</externalid>
        <name>NEU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6BMK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360436</externalid>
        <name>GBA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MND2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358459</externalid>
        <name>SMPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334488</externalid>
        <name>PSAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359024</externalid>
        <name>CERK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358608</externalid>
        <name>ARSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374231</externalid>
        <name>ST8SIA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358579</externalid>
        <name>SUMF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410383</externalid>
        <name>FUT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q1T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358527</externalid>
        <name>ASAH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358616</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358612</externalid>
        <name>ARSI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343125</externalid>
        <name>M6PR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358306</externalid>
        <name>GBA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358620</externalid>
        <name>ARSK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410426</externalid>
        <name>FUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358452</externalid>
        <name>NEU3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358553</externalid>
        <name>ARSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358510</externalid>
        <name>GALC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358604</externalid>
        <name>ARSG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N665</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389471</externalid>
        <name>UGT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358478</externalid>
        <name>SMPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400104</externalid>
        <name>GALGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360443</externalid>
        <name>GBA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417874</externalid>
        <name>A4GALT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358518</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348421</externalid>
        <name>B3GNT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410582</externalid>
        <name>B3GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358420</externalid>
        <name>NEU4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358565</externalid>
        <name>STS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358600</externalid>
        <name>ARSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358575</externalid>
        <name>SUMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374266</externalid>
        <name>ST3GAL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359031</externalid>
        <name>ENPP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358317</externalid>
        <name>GM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9840994</externalid>
        <name>choline phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>295975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845590</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844848</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846303</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78569</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605734</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1660672</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844852</externalid>
        <name>ganglioside GM2 (18:0) (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429777</externalid>
        <name>sphingomyelin d18:1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840473</externalid>
        <name>1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840463</externalid>
        <name>PE(16:1(9Z)/16:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845501</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605616</externalid>
        <name>N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5250592</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840849</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845542</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840626</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840469</externalid>
        <name>PE(18:0/16:1(9Z)) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844857</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845517</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846339</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842019</externalid>
        <name>(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845499</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845579</externalid>
        <name>ganglioside GD3(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846338</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841183</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841240</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840447</externalid>
        <name>PE(16:1(9Z)/14:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840845</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;3)-alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844864</externalid>
        <name>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5228369</externalid>
        <name>alpha-Neu5NAc-(2-&gt;8)-alpha-Neu5NAc-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840456</externalid>
        <name>1-oleoyl-2-palmitoleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36715</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide(d18:1(4E))</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845603</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNac-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87787</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9840309</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9840310</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1660662</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428157</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9840309</externalid>
    <name>Glycosphingolipid biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9840309</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358949</externalid>
        <name>UGCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389471</externalid>
        <name>UGT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374244</externalid>
        <name>ST6GALNAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348421</externalid>
        <name>B3GNT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410582</externalid>
        <name>B3GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359024</externalid>
        <name>CERK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400104</externalid>
        <name>GALGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374266</externalid>
        <name>ST3GAL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410426</externalid>
        <name>FUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374231</externalid>
        <name>ST8SIA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417874</externalid>
        <name>A4GALT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410383</externalid>
        <name>FUT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q1T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845590</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844848</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846303</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78569</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605734</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1660672</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844852</externalid>
        <name>ganglioside GM2 (18:0) (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845501</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;8)-alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1605616</externalid>
        <name>N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5250592</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845542</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844857</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-stearoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845517</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846339</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845499</externalid>
        <name>beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845579</externalid>
        <name>ganglioside GD3(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78436</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846338</externalid>
        <name>alpha-L-Fuc-(1-&gt;2)-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844864</externalid>
        <name>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5228369</externalid>
        <name>alpha-Neu5NAc-(2-&gt;8)-alpha-Neu5NAc-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36715</externalid>
        <name>N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosylceramide(d18:1(4E))</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845603</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-GalNac-(1-&gt;4)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87787</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9840309</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660662</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9840310</externalid>
    <name>Glycosphingolipid catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9840310</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358487</externalid>
        <name>SMPD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358604</externalid>
        <name>ARSG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N665</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358409</externalid>
        <name>NEU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358478</externalid>
        <name>SMPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358443</externalid>
        <name>GLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B725</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358432</externalid>
        <name>NEU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6BMK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360436</externalid>
        <name>GBA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MND2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358459</externalid>
        <name>SMPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334488</externalid>
        <name>PSAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358608</externalid>
        <name>ARSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360443</externalid>
        <name>GBA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358579</externalid>
        <name>SUMF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358376</externalid>
        <name>GLB1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358527</externalid>
        <name>ASAH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358323</externalid>
        <name>HEXA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358616</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358518</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358335</externalid>
        <name>HEXB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H7BWW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358612</externalid>
        <name>ARSI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358420</externalid>
        <name>NEU4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358600</externalid>
        <name>ARSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358565</externalid>
        <name>STS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358575</externalid>
        <name>SUMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358306</externalid>
        <name>GBA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343125</externalid>
        <name>M6PR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358620</externalid>
        <name>ARSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358380</externalid>
        <name>GLB1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358384</externalid>
        <name>GLB1L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358452</externalid>
        <name>NEU3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358553</externalid>
        <name>ARSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358510</externalid>
        <name>GALC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358317</externalid>
        <name>GM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359031</externalid>
        <name>ENPP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840994</externalid>
        <name>choline phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>295975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840849</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840626</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195476</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840625</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840469</externalid>
        <name>PE(18:0/16:1(9Z)) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842019</externalid>
        <name>(S,S)-bis-(3-oleoylglycero)-1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>139150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840633</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>79218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840895</externalid>
        <name>beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90163</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9844580</externalid>
        <name>1-(3-O-sulfonato-beta-D-galactosyl)ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31051</externalid>
        <name>alpha-D-galactose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28061</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840452</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphingosine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841183</externalid>
        <name>alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429777</externalid>
        <name>sphingomyelin d18:1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840473</externalid>
        <name>1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840463</externalid>
        <name>PE(16:1(9Z)/16:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841240</externalid>
        <name>beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840447</externalid>
        <name>PE(16:1(9Z)/14:0) zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840845</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;3)-alpha-D-galactosyl-(1-&gt;4)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840878</externalid>
        <name>N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-beta-D-3-sulfogalactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90164</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30415</externalid>
        <name>phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840456</externalid>
        <name>1-oleoyl-2-palmitoleoyl-sn-glycero-3-phosphoethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78810</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9840310</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1660662</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9845614</externalid>
    <name>Sphingolipid catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9845614</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SGPP2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1B8N2</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>PLPP3</name>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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        <name>N-acylsphingoid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
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      <smallmolecule>
        <externalid>30291</externalid>
        <name>hexadecanal</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>zinc(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9843874</externalid>
        <name>phytosphingosine(1+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>hydron</name>
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      <smallmolecule>
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        <name>O-phosphoethanolamine</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9844331</externalid>
        <name>sphinganine 1-phosphate(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
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      <smallmolecule>
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        <name>water</name>
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      <smallmolecule>
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        <name>sphingoid base(1+)</name>
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      <smallmolecule>
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        <name>sphingosine(1+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>428282</externalid>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-428157</externalid>
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    <name>Metabolism of steroids</name>
    <biosystemtype>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327805</externalid>
        <name>HSD3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401309</externalid>
        <name>OSBPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401461</externalid>
        <name>OSBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>36327</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395395</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760862</externalid>
        <name>(R)-5-phosphonatomevalonate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317274</externalid>
        <name>(R)-mevalonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163917</externalid>
        <name>zymosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31337</externalid>
        <name>cholesta-5,7-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946143</externalid>
        <name>4,4-dimethyl-8,14-cholestadien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945113</externalid>
        <name>presqualene diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945824</externalid>
        <name>3beta-hydroxy-4beta-methyl-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36929</externalid>
        <name>14-demethyllanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945806</externalid>
        <name>3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945104</externalid>
        <name>4beta-methylzymosterol-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327984</externalid>
        <name>4-methylpentan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395396</externalid>
        <name>pregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945793</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945112</externalid>
        <name>4alpha-carboxyzymosterol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395389</externalid>
        <name>17alpha-hydroxypregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018639</externalid>
        <name>calcitroic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945089</externalid>
        <name>prenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31165</externalid>
        <name>(S)-2,3-epoxysqualene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945105</externalid>
        <name>geranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31383</externalid>
        <name>5alpha-cholest-7-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36931</externalid>
        <name>24,25-dihydrolanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945788</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36927</externalid>
        <name>7-dehydrodesmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945090</externalid>
        <name>presqualene monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30050</externalid>
        <name>steroid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32285</externalid>
        <name>desmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945782</externalid>
        <name>5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36923</externalid>
        <name>4alpha-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841192</externalid>
        <name>steroid sulfate oxoanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327983</externalid>
        <name>3-dehydro-4-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946136</externalid>
        <name>4,4-dimethyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>195686</externalid>
        <name>5alpha-cholesta-7,24-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-191273</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1655829</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194068</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196791</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8957322</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-191273</externalid>
    <name>Cholesterol biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-191273</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359120</externalid>
        <name>SREBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RVY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327416</externalid>
        <name>fdft1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6IE76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359126</externalid>
        <name>SREBF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328564</externalid>
        <name>EBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328616</externalid>
        <name>DHCR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327391</externalid>
        <name>LSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327427</externalid>
        <name>MVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328623</externalid>
        <name>DHCR24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414205</externalid>
        <name>GGPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327366</externalid>
        <name>SQLE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328397</externalid>
        <name>SC4MOL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327375</externalid>
        <name>HMGCS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327407</externalid>
        <name>IDI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T853</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327398</externalid>
        <name>MVK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328390</externalid>
        <name>HSD17B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398130</externalid>
        <name>ACAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327382</externalid>
        <name>HMGCR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z064</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328404</externalid>
        <name>NSDHL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328557</externalid>
        <name>SC5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328413</externalid>
        <name>LBR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377357</externalid>
        <name>ARV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327436</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328429</externalid>
        <name>TM7SF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328420</externalid>
        <name>CYP51A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405951</externalid>
        <name>PLPP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945089</externalid>
        <name>prenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31165</externalid>
        <name>(S)-2,3-epoxysqualene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760862</externalid>
        <name>(R)-5-phosphonatomevalonate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945105</externalid>
        <name>geranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31383</externalid>
        <name>5alpha-cholest-7-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36931</externalid>
        <name>24,25-dihydrolanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945788</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317274</externalid>
        <name>(R)-mevalonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36927</externalid>
        <name>7-dehydrodesmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163917</externalid>
        <name>zymosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945090</externalid>
        <name>presqualene monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31337</externalid>
        <name>cholesta-5,7-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946143</externalid>
        <name>4,4-dimethyl-8,14-cholestadien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945113</externalid>
        <name>presqualene diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945824</externalid>
        <name>3beta-hydroxy-4beta-methyl-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36929</externalid>
        <name>14-demethyllanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32285</externalid>
        <name>desmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945806</externalid>
        <name>3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945782</externalid>
        <name>5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36923</externalid>
        <name>4alpha-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327983</externalid>
        <name>3-dehydro-4-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945104</externalid>
        <name>4beta-methylzymosterol-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946136</externalid>
        <name>4,4-dimethyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945793</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>195686</externalid>
        <name>5alpha-cholesta-7,24-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945112</externalid>
        <name>4alpha-carboxyzymosterol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9969896</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807047</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807062</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9969901</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-191273</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9969896</externalid>
    <name>Lanosterol biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9969896</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10414205</externalid>
        <name>GGPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327407</externalid>
        <name>IDI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T853</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327398</externalid>
        <name>MVK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398130</externalid>
        <name>ACAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327366</externalid>
        <name>SQLE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327436</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327382</externalid>
        <name>HMGCR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z064</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327416</externalid>
        <name>fdft1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6IE76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327391</externalid>
        <name>LSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327427</externalid>
        <name>MVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327375</externalid>
        <name>HMGCS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405951</externalid>
        <name>PLPP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945089</externalid>
        <name>prenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31165</externalid>
        <name>(S)-2,3-epoxysqualene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760862</externalid>
        <name>(R)-5-phosphonatomevalonate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945105</externalid>
        <name>geranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317274</externalid>
        <name>(R)-mevalonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945090</externalid>
        <name>presqualene monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945113</externalid>
        <name>presqualene diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9969896</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-191273</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6807047</externalid>
    <name>Cholesterol biosynthesis via desmosterol (Bloch pathway)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6807047</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328390</externalid>
        <name>HSD17B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328413</externalid>
        <name>LBR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328429</externalid>
        <name>TM7SF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328404</externalid>
        <name>NSDHL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328420</externalid>
        <name>CYP51A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328564</externalid>
        <name>EBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328616</externalid>
        <name>DHCR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328397</externalid>
        <name>SC4MOL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328557</externalid>
        <name>SC5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328623</externalid>
        <name>DHCR24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>36927</externalid>
        <name>7-dehydrodesmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36929</externalid>
        <name>14-demethyllanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32285</externalid>
        <name>desmosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163917</externalid>
        <name>zymosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>195686</externalid>
        <name>5alpha-cholesta-7,24-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36923</externalid>
        <name>4alpha-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945112</externalid>
        <name>4alpha-carboxyzymosterol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143575</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327983</externalid>
        <name>3-dehydro-4-methylzymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945104</externalid>
        <name>4beta-methylzymosterol-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64925</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6807047</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-191273</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6807062</externalid>
    <name>Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6807062</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328390</externalid>
        <name>HSD17B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328429</externalid>
        <name>TM7SF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328404</externalid>
        <name>NSDHL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359120</externalid>
        <name>SREBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RVY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359126</externalid>
        <name>SREBF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328623</externalid>
        <name>DHCR24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR14</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9945824</externalid>
        <name>3beta-hydroxy-4beta-methyl-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946136</externalid>
        <name>4,4-dimethyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945793</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87051</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945806</externalid>
        <name>3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945782</externalid>
        <name>5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946143</externalid>
        <name>4,4-dimethyl-8,14-cholestadien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36931</externalid>
        <name>24,25-dihydrolanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9945788</externalid>
        <name>4alpha-methyl-5alpha-cholest-8-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87050</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6807062</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-191273</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9969901</externalid>
    <name>Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9969901</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>DHCR7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J5</externalid>
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          </protein>
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      <gene>
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        <name>EBP</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBT8</externalid>
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          </protein>
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      <gene>
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        <name>DHCR24</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QR14</externalid>
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          </protein>
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      <smallmolecule>
        <externalid>31337</externalid>
        <name>cholesta-5,7-dien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17759</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35211</externalid>
        <name>5alpha-cholest-8-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>37329</externalid>
        <name>zymosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31383</externalid>
        <name>5alpha-cholest-7-en-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17168</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9969901</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-191273</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1655829</externalid>
    <name>Regulation of cholesterol biosynthesis by SREBP (SREBF)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1655829</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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        <name>SCAP</name>
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          <protein>
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              <externalid>F1MQ33</externalid>
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          </protein>
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      <gene>
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        <name>MBTPS2</name>
        <entity>
          <protein>
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              <externalid>Q0III2</externalid>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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        <entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1ML06</externalid>
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      <gene>
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        <name>RAN</name>
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              <externalid>Q3T054</externalid>
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      <gene>
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          <protein>
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              <externalid>Q08E55</externalid>
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        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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    <name>Bile acid and bile salt metabolism</name>
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    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>NR1H4</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>LOC527068</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N3Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327745</externalid>
        <name>ACOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327716</externalid>
        <name>HSD3B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327631</externalid>
        <name>AKR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401309</externalid>
        <name>OSBPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328289</externalid>
        <name>SLCO1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401461</externalid>
        <name>OSBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402287</externalid>
        <name>STARD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>36327</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395395</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-192105</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159418</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-194068</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-192105</externalid>
    <name>Synthesis of bile acids and bile salts</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-192105</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366868</externalid>
        <name>OSBPL1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401317</externalid>
        <name>OSBPL7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327705</externalid>
        <name>CYP46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327698</externalid>
        <name>AMACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401321</externalid>
        <name>OSBPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327919</externalid>
        <name>ABCB11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401313</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327729</externalid>
        <name>CYP39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401305</externalid>
        <name>OSBPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327745</externalid>
        <name>ACOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327716</externalid>
        <name>HSD3B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327631</externalid>
        <name>AKR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401309</externalid>
        <name>OSBPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401461</externalid>
        <name>OSBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>36327</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395395</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-193368</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193775</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193807</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-192105</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194068</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193368</externalid>
    <name>Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193368</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10327590</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327754</externalid>
        <name>SCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327698</externalid>
        <name>AMACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327919</externalid>
        <name>ABCB11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327745</externalid>
        <name>ACOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327716</externalid>
        <name>HSD3B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327736</externalid>
        <name>HSD17B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK91</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327631</externalid>
        <name>AKR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327928</externalid>
        <name>ACOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>36327</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193009</externalid>
        <name>7alpha-hydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17899</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193016</externalid>
        <name>(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31579</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37359</externalid>
        <name>7alpha,12alpha-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36247</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213278</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37355</externalid>
        <name>7alpha-hydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193481</externalid>
        <name>3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193015</externalid>
        <name>(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36393</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213279</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36513</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37343</externalid>
        <name>3alpha,7alpha-dihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37357</externalid>
        <name>5beta-cholestane-3alpha,7alpha-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28047</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193011</externalid>
        <name>7alpha,12alpha-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37369</externalid>
        <name>3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193368</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-192105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193775</externalid>
    <name>Synthesis of bile acids and bile salts via 24-hydroxycholesterol</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193775</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327729</externalid>
        <name>CYP39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327705</externalid>
        <name>CYP46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327716</externalid>
        <name>HSD3B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327698</externalid>
        <name>AMACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327631</externalid>
        <name>AKR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327937</externalid>
        <name>SLC27A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395395</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395210</externalid>
        <name>(24S)-7alpha,24-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327971</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395212</externalid>
        <name>(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63830</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37349</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9032305</externalid>
        <name>3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2265577</externalid>
        <name>(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>213281</externalid>
        <name>3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327970</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63835</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395858</externalid>
        <name>(24S)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63848</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327979</externalid>
        <name>(24S)-7alpha,24-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63838</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327963</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327969</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,24-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63831</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395864</externalid>
        <name>(24S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-al</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63849</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327973</externalid>
        <name>(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193775</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-192105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193807</externalid>
    <name>Synthesis of bile acids and bile salts via 27-hydroxycholesterol</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193807</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327716</externalid>
        <name>HSD3B7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327631</externalid>
        <name>AKR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395216</externalid>
        <name>7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327977</externalid>
        <name>7alpha,26-dihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37345</externalid>
        <name>5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37341</externalid>
        <name>5beta-cholestane-3alpha,7alpha,26-triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395221</externalid>
        <name>7alpha,26-dihydroxy-5beta-cholestan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48778</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9617285</externalid>
        <name>7alpha,12alpha,26-trihydroxycholest-4-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48833</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193007</externalid>
        <name>7alpha,26-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193807</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-192105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159418</externalid>
    <name>Recycling of bile acids and salts</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159418</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328282</externalid>
        <name>SLC10A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328303</externalid>
        <name>SLC10A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414462</externalid>
        <name>SLC51A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T124</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328296</externalid>
        <name>ABCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322100</externalid>
        <name>SLC27A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414466</externalid>
        <name>SLC51B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNM1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327919</externalid>
        <name>ABCB11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGI0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377831</externalid>
        <name>FABP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DID8</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10328289</externalid>
        <name>SLCO1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDW7</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10402287</externalid>
        <name>STARD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760915</externalid>
        <name>chenodeoxycholoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760759</externalid>
        <name>choloyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-159418</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194068</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196071</externalid>
    <name>Metabolism of steroid hormones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196071</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327872</externalid>
        <name>HSD17B12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327861</externalid>
        <name>CYP19A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328582</externalid>
        <name>STARD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328575</externalid>
        <name>AKR1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A493UA87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413249</externalid>
        <name>SRD5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355537</externalid>
        <name>SERPINA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328255</externalid>
        <name>HSD11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8K3KFT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397010</externalid>
        <name>HSD17B14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327868</externalid>
        <name>HSD17B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RUH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328261</externalid>
        <name>HSD11B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387203</externalid>
        <name>HSD17B11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327834</externalid>
        <name>CYP11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327886</externalid>
        <name>LOC132342070</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327890</externalid>
        <name>CYP17A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05185</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413242</externalid>
        <name>SRD5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328592</externalid>
        <name>STARD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347222</externalid>
        <name>HSD17B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328586</externalid>
        <name>STARD3NL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358565</externalid>
        <name>STS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328596</externalid>
        <name>STARD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369524</externalid>
        <name>AKR1B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N678</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400480</externalid>
        <name>HSD17b2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0PHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328604</externalid>
        <name>STAR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28918</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327805</externalid>
        <name>HSD3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345695</externalid>
        <name>SRD5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395389</externalid>
        <name>17alpha-hydroxypregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841192</externalid>
        <name>steroid sulfate oxoanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327984</externalid>
        <name>4-methylpentan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395396</externalid>
        <name>pregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30050</externalid>
        <name>steroid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-196108</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194002</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193993</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193048</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193144</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-196071</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196108</externalid>
    <name>Pregnenolone biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196108</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328592</externalid>
        <name>STARD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328582</externalid>
        <name>STARD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328575</externalid>
        <name>AKR1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A493UA87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328586</externalid>
        <name>STARD3NL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328604</externalid>
        <name>STAR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28918</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327834</externalid>
        <name>CYP11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328596</externalid>
        <name>STARD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2327984</externalid>
        <name>4-methylpentan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63910</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196108</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-194002</externalid>
    <name>Glucocorticoid biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-194002</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355537</externalid>
        <name>SERPINA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328255</externalid>
        <name>HSD11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8K3KFT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327805</externalid>
        <name>HSD3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328261</externalid>
        <name>HSD11B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327886</externalid>
        <name>LOC132342070</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327890</externalid>
        <name>CYP17A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05185</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395389</externalid>
        <name>17alpha-hydroxypregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-194002</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193993</externalid>
    <name>Mineralocorticoid biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193993</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327805</externalid>
        <name>HSD3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395396</externalid>
        <name>pregn-5-ene-3,20-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193993</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193048</externalid>
    <name>Androgen biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193048</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327872</externalid>
        <name>HSD17B12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413242</externalid>
        <name>SRD5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413249</externalid>
        <name>SRD5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327805</externalid>
        <name>HSD3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327868</externalid>
        <name>HSD17B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RUH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345695</externalid>
        <name>SRD5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327886</externalid>
        <name>LOC132342070</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327890</externalid>
        <name>CYP17A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05185</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>211325</externalid>
        <name>17alpha-hydroxypregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31359</externalid>
        <name>17alpha-hydroxyprogesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193048</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193144</externalid>
    <name>Estrogen biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193144</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327861</externalid>
        <name>CYP19A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387203</externalid>
        <name>HSD17B11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347222</externalid>
        <name>HSD17B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369524</externalid>
        <name>AKR1B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N678</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400480</externalid>
        <name>HSD17b2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0PHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397010</externalid>
        <name>HSD17B14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193144</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196791</externalid>
    <name>Vitamin D (calciferol) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196791</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332580</externalid>
        <name>CUBN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335834</externalid>
        <name>VDR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334341</externalid>
        <name>LRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334332</externalid>
        <name>LGMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332598</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332720</externalid>
        <name>CYP27B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312799</externalid>
        <name>PIAS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369694</externalid>
        <name>SUMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61955</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332703</externalid>
        <name>CYP2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332571</externalid>
        <name>GC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H744</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018639</externalid>
        <name>calcitroic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196791</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8848584</externalid>
    <name>Wax and plasmalogen biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8848584</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339301</externalid>
        <name>FAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339311</externalid>
        <name>FAR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388045</externalid>
        <name>AWAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317458</externalid>
        <name>DHRS7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317447</externalid>
        <name>AGPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317443</externalid>
        <name>GNPAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30793</externalid>
        <name>hexadecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848505</externalid>
        <name>palmityl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762227</externalid>
        <name>1-palmitoylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58303</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327673</externalid>
        <name>1-hexadecyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9640463</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75896</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8848584</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9640463</externalid>
    <name>Wax biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9640463</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339301</externalid>
        <name>FAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339311</externalid>
        <name>FAR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388045</externalid>
        <name>AWAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30793</externalid>
        <name>hexadecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316740</externalid>
        <name>icosan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848505</externalid>
        <name>palmityl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316754</externalid>
        <name>wax ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9640463</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8848584</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75896</externalid>
    <name>Plasmalogen biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75896</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317458</externalid>
        <name>DHRS7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317447</externalid>
        <name>AGPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317443</externalid>
        <name>GNPAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674791</externalid>
        <name>glycerone phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30793</externalid>
        <name>hexadecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762227</externalid>
        <name>1-palmitoylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58303</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327673</externalid>
        <name>1-hexadecyl-sn-glycerol 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762306</externalid>
        <name>1-alkylglycerone 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73315</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75896</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8848584</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74182</externalid>
    <name>Ketone body metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74182</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10388055</externalid>
        <name>BDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316303</externalid>
        <name>OXCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316071</externalid>
        <name>BDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02337</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389860</externalid>
        <name>HMGCLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316312</externalid>
        <name>HMGCL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29448</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387796</externalid>
        <name>AACS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N412</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316082</externalid>
        <name>HMGCS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402489</externalid>
        <name>ACSS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30018</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696452</externalid>
        <name>(R)-3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31211</externalid>
        <name>(R)-3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-77111</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77108</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74182</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77111</externalid>
    <name>Synthesis of Ketone Bodies</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77111</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10388055</externalid>
        <name>BDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316071</externalid>
        <name>BDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02337</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389860</externalid>
        <name>HMGCLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316312</externalid>
        <name>HMGCL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29448</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387796</externalid>
        <name>AACS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N412</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316082</externalid>
        <name>HMGCS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402489</externalid>
        <name>ACSS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30018</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696452</externalid>
        <name>(R)-3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10983</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31211</externalid>
        <name>(R)-3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77111</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74182</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77108</externalid>
    <name>Utilization of Ketone Bodies</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77108</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316303</externalid>
        <name>OXCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316071</externalid>
        <name>BDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02337</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31211</externalid>
        <name>(R)-3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735741</externalid>
        <name>acetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77108</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74182</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018678</externalid>
    <name>Biosynthesis of specialized proresolving mediators (SPMs)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018678</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325603</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333970</externalid>
        <name>ALOX5AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365857</externalid>
        <name>EPHX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QS88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9038578</externalid>
        <name>(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140196</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916396</externalid>
        <name>22-hydroxyprotectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024562</externalid>
        <name>aspirin-triggered resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9020465</externalid>
        <name>(18S)-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916421</externalid>
        <name>resolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132079</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022662</externalid>
        <name>resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024864</externalid>
        <name>4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024897</externalid>
        <name>(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138653</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024488</externalid>
        <name>4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911702</externalid>
        <name>(7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142720</externalid>
        <name>6-epi-lipoxin A4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911738</externalid>
        <name>5-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911731</externalid>
        <name>(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024565</externalid>
        <name>7S,8S-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916398</externalid>
        <name>17(R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025146</externalid>
        <name>10(S),17(S)-dihydroxy-omega 6-docosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138674</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916747</externalid>
        <name>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137442</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916381</externalid>
        <name>(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916399</externalid>
        <name>(17S)-HDHA(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916404</externalid>
        <name>resolvin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025156</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024571</externalid>
        <name>aspirin-triggered resolvin D1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916771</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024476</externalid>
        <name>7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138602</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024587</externalid>
        <name>4S(5)-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024861</externalid>
        <name>4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916416</externalid>
        <name>17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916380</externalid>
        <name>8-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916411</externalid>
        <name>18(R)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142798</externalid>
        <name>15-epi-lipoxin B4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024866</externalid>
        <name>resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024581</externalid>
        <name>aspirin-triggered resolvin D2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916384</externalid>
        <name>15-oxolipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78311</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911700</externalid>
        <name>(4Z,8E,10Z,13Z,16Z,19Z)-7-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023656</externalid>
        <name>(18R)-resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024856</externalid>
        <name>resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916382</externalid>
        <name>18(S)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132083</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916751</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911706</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140260</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916402</externalid>
        <name>18-oxoresolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762300</externalid>
        <name>(4Z,7Z,10Z,14E,16Z,19Z)-13-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916405</externalid>
        <name>17-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024860</externalid>
        <name>7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916394</externalid>
        <name>(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911735</externalid>
        <name>prostaglandin H3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916385</externalid>
        <name>lipoxin B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023697</externalid>
        <name>(5Z,8Z,11Z,14Z,16E,18R)-18-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916392</externalid>
        <name>5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916409</externalid>
        <name>protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023704</externalid>
        <name>5S(6)-epoxy-18(R)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024580</externalid>
        <name>aspirin-triggered resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916383</externalid>
        <name>aspirin-triggered protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022663</externalid>
        <name>5(S)6-epoxy-18(S)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138490</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2142700</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018679</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018683</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9027604</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9018678</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-556833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142700</externalid>
    <name>Biosynthesis of Lipoxins (LX)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142700</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333970</externalid>
        <name>ALOX5AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915914</externalid>
        <name>15(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57446</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915838</externalid>
        <name>5(S)-HPETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142798</externalid>
        <name>15-epi-lipoxin B4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915832</externalid>
        <name>leukotriene A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57463</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2142720</externalid>
        <name>6-epi-lipoxin A4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916384</externalid>
        <name>15-oxolipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78311</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915907</externalid>
        <name>15(R)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916385</externalid>
        <name>lipoxin B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142700</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018679</externalid>
    <name>Biosynthesis of EPA-derived SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018679</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022662</externalid>
        <name>resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916402</externalid>
        <name>18-oxoresolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916411</externalid>
        <name>18(R)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9020465</externalid>
        <name>(18S)-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023697</externalid>
        <name>(5Z,8Z,11Z,14Z,16E,18R)-18-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916392</externalid>
        <name>5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023704</externalid>
        <name>5S(6)-epoxy-18(R)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023656</externalid>
        <name>(18R)-resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916394</externalid>
        <name>(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916382</externalid>
        <name>18(S)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132083</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022663</externalid>
        <name>5(S)6-epoxy-18(S)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138490</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9018896</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9023661</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9018679</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018896</externalid>
    <name>Biosynthesis of E-series 18(S)-resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018896</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022662</externalid>
        <name>resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916402</externalid>
        <name>18-oxoresolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9020465</externalid>
        <name>(18S)-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138387</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916394</externalid>
        <name>(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916382</externalid>
        <name>18(S)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132083</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9022663</externalid>
        <name>5(S)6-epoxy-18(S)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138490</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9018896</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018679</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9023661</externalid>
    <name>Biosynthesis of E-series 18(R)-resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9023661</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023704</externalid>
        <name>5S(6)-epoxy-18(R)-HEPE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916392</externalid>
        <name>5(S)-hydroperoxy-18(R)-hydroxy-(6E,8Z,11Z,14Z,16E)-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132218</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916411</externalid>
        <name>18(R)-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90818</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023656</externalid>
        <name>(18R)-resolvin E3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9023697</externalid>
        <name>(5Z,8Z,11Z,14Z,16E,18R)-18-hydroperoxyicosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9023661</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018679</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018677</externalid>
    <name>Biosynthesis of DHA-derived SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018677</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325603</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365857</externalid>
        <name>EPHX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QS88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916416</externalid>
        <name>17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916380</externalid>
        <name>8-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9038578</externalid>
        <name>(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140196</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916396</externalid>
        <name>22-hydroxyprotectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024562</externalid>
        <name>aspirin-triggered resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024866</externalid>
        <name>resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916421</externalid>
        <name>resolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132079</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024581</externalid>
        <name>aspirin-triggered resolvin D2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024856</externalid>
        <name>resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024864</externalid>
        <name>4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024897</externalid>
        <name>(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138653</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024488</externalid>
        <name>4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916405</externalid>
        <name>17-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024860</externalid>
        <name>7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024565</externalid>
        <name>7S,8S-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916398</externalid>
        <name>17(R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916409</externalid>
        <name>protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916747</externalid>
        <name>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137442</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916381</externalid>
        <name>(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916399</externalid>
        <name>(17S)-HDHA(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916404</externalid>
        <name>resolvin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024580</externalid>
        <name>aspirin-triggered resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916383</externalid>
        <name>aspirin-triggered protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024571</externalid>
        <name>aspirin-triggered resolvin D1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024476</externalid>
        <name>7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138602</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024587</externalid>
        <name>4S(5)-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024861</externalid>
        <name>4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138641</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9018676</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9020265</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018681</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018682</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026395</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9018677</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018676</externalid>
    <name>Biosynthesis of D-series resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018676</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365778</externalid>
        <name>HPGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q309F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916380</externalid>
        <name>8-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024864</externalid>
        <name>4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138647</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024866</externalid>
        <name>resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916399</externalid>
        <name>(17S)-HDHA(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916404</externalid>
        <name>resolvin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916405</externalid>
        <name>17-oxoresolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916421</externalid>
        <name>resolvin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132079</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024860</externalid>
        <name>7(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024856</externalid>
        <name>resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024861</externalid>
        <name>4(S)-hydroperoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138641</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9018676</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9020265</externalid>
    <name>Biosynthesis of aspirin-triggered D-series resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9020265</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365847</externalid>
        <name>GPX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024562</externalid>
        <name>aspirin-triggered resolvin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024565</externalid>
        <name>7S,8S-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024488</externalid>
        <name>4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024580</externalid>
        <name>aspirin-triggered resolvin D4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024581</externalid>
        <name>aspirin-triggered resolvin D2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916398</externalid>
        <name>17(R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024571</externalid>
        <name>aspirin-triggered resolvin D1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024476</externalid>
        <name>7(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138602</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024587</externalid>
        <name>4S(5)-epoxy-17R-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138612</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9020265</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018681</externalid>
    <name>Biosynthesis of protectins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018681</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334192</externalid>
        <name>LTA4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916416</externalid>
        <name>17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916396</externalid>
        <name>22-hydroxyprotectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916409</externalid>
        <name>protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916381</externalid>
        <name>(16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140313</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024897</externalid>
        <name>(4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138653</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916383</externalid>
        <name>aspirin-triggered protectin D1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916390</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024470</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17R,19Z)-17-hydroperoxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138590</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9018681</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018682</externalid>
    <name>Biosynthesis of maresins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018682</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365857</externalid>
        <name>EPHX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QS88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9038578</externalid>
        <name>(7S,14S)-bis(hydroperoxy)-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140196</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916747</externalid>
        <name>(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137442</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9027307</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9018682</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9027307</externalid>
    <name>Biosynthesis of maresin-like SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9027307</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916739</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916776</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136536</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916733</externalid>
        <name>(4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136535</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916768</externalid>
        <name>(14R)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916738</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916758</externalid>
        <name>(14S)-HDoHE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9027307</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018682</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026395</externalid>
    <name>Biosynthesis of DHA-derived sulfido conjugates</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026395</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325603</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9026762</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026766</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9026395</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018677</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026762</externalid>
    <name>Biosynthesis of maresin conjugates in tissue regeneration (MCTR)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026762</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325603</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916410</externalid>
        <name>(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916746</externalid>
        <name>(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137407</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026762</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026395</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026766</externalid>
    <name>Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026766</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333976</externalid>
        <name>LTC4S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9024867</externalid>
        <name>7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916762</externalid>
        <name>(8S)-glutathionyl-(7R,17S)-dihydroxy-(4Z,9,11,13Z,15E,19Z)-docosahexaenoate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140409</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026766</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026395</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018683</externalid>
    <name>Biosynthesis of DPA-derived SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018683</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025146</externalid>
        <name>10(S),17(S)-dihydroxy-omega 6-docosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138674</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916751</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025156</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916771</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9025106</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9025094</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9018683</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9025106</externalid>
    <name>Biosynthesis of DPAn-6 SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9025106</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025156</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,17S)-17-hydroxydocosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916771</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9025146</externalid>
        <name>10(S),17(S)-dihydroxy-omega 6-docosapentaenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138674</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916751</externalid>
        <name>(4Z,7Z,10Z,12E,14S,16Z)-14-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9025106</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018683</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9025094</externalid>
    <name>Biosynthesis of DPAn-3 SPMs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9025094</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9026286</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026290</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9026403</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9025094</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018683</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026286</externalid>
    <name>Biosynthesis of DPAn-3-derived protectins and resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026286</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365866</externalid>
        <name>ALOX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27479</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916744</externalid>
        <name>(16S,17S)-epoxy-(7Z,10Z,12E,14E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916773</externalid>
        <name>(8E,10Z,13Z,15E,19Z)-7,17-bis(hydroperoxy)docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140381</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916740</externalid>
        <name>(7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140291</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916742</externalid>
        <name>7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140293</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026286</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9025094</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026290</externalid>
    <name>Biosynthesis of DPAn-3-derived maresins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026290</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365769</externalid>
        <name>ALOX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916736</externalid>
        <name>(7Z,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140289</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916756</externalid>
        <name>14(S),21-dihydroxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916386</externalid>
        <name>(4Z,8E,10Z,12E,14S,16Z,19Z)-14-hydroperoxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916743</externalid>
        <name>(7Z,9E,11E,16Z,19Z)-13,14-epoxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140235</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026290</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9025094</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026403</externalid>
    <name>Biosynthesis of DPAn-3-derived 13-series resolvins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026403</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9916763</externalid>
        <name>resolvin T1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134656</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916775</externalid>
        <name>resolvin T2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916764</externalid>
        <name>resolvin T3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134658</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762313</externalid>
        <name>(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916757</externalid>
        <name>resolvin T4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134659</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026403</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9025094</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9027604</externalid>
    <name>Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9027604</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
        <externalid>10365835</externalid>
        <name>PTGS2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333982</externalid>
        <name>ALOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ78</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911731</externalid>
        <name>(8E,10Z,13Z,16Z,19Z)-7-hydroxydocosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>140375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762300</externalid>
        <name>(4Z,7Z,10Z,14E,16Z,19Z)-13-hydroxydocosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>90815</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9911702</externalid>
        <name>(7Z,10Z,13Z,15E,19Z)-17-hydroperoxydocosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>133797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911700</externalid>
        <name>(4Z,8E,10Z,13Z,16Z,19Z)-7-hydroxydocosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>140373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911738</externalid>
        <name>5-HEPE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911735</externalid>
        <name>prostaglandin H3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911706</externalid>
        <name>(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>140260</externalid>
        </xref>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9027604</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9018678</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-163685</externalid>
    <name>Integration of energy metabolism</name>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
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              <externalid>A2VDS4</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZY8</externalid>
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      <gene>
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        <name>ADRA2A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
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          </protein>
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      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
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      <gene>
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        <name>ACSL3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
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      <gene>
        <externalid>10398391</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M564</externalid>
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          </protein>
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      <gene>
        <externalid>10313943</externalid>
        <name>TKT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z014</externalid>
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      <gene>
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          <protein>
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              <externalid>P11017</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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              <externalid>E1BHU9</externalid>
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          <protein>
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              <externalid>F6Q9S4</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          <protein>
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              <externalid>E1BKE7</externalid>
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              <externalid>P02698</externalid>
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      <gene>
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              <externalid>P62871</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
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      <gene>
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              <externalid>G3MZT6</externalid>
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              <externalid>A0A3Q1LZ55</externalid>
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      <gene>
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      <gene>
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          <protein>
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              <externalid>P63217</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1MX37</externalid>
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      <gene>
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              <externalid>A0A3Q1LVS7</externalid>
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          </protein>
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      <gene>
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        <name>ABCC8</name>
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          <protein>
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              <externalid>E1BKR6</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G5E5C8</externalid>
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      <gene>
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        <name>GNG12</name>
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          <protein>
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          <protein>
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          <protein>
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              <externalid>P63097</externalid>
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      <gene>
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        <name>CD36</name>
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      <gene>
        <externalid>10398403</externalid>
        <name>ADIPOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332866</externalid>
        <name>CACNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322990</externalid>
        <name>GCGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398397</externalid>
        <name>ADIPOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925918</externalid>
        <name>sedoheptulose 7-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114814</externalid>
        <name>D-erythrose 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-422356</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163359</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163754</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163680</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-163685</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-422356</externalid>
    <name>Regulation of insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-422356</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10334095</externalid>
        <name>KCNJ11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328926</externalid>
        <name>SLC2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27674</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343313</externalid>
        <name>ACSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332884</externalid>
        <name>CACNA2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336335</externalid>
        <name>GLP1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334099</externalid>
        <name>ABCC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334112</externalid>
        <name>RAPGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332870</externalid>
        <name>CACNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338236</externalid>
        <name>KCNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334082</externalid>
        <name>CACNA1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338232</externalid>
        <name>KCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334072</externalid>
        <name>CACNA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332866</externalid>
        <name>CACNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-400042</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399997</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400451</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381676</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-422356</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163685</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-400042</externalid>
    <name>Adrenaline,noradrenaline inhibits insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-400042</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-400042</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422356</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399997</externalid>
    <name>Acetylcholine regulates insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-399997</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-399997</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422356</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-400451</externalid>
    <name>Free fatty acids regulate insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-400451</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343313</externalid>
        <name>ACSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-434316</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-434313</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-400451</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422356</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-434316</externalid>
    <name>Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-434316</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-434316</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400451</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-434313</externalid>
    <name>Intracellular metabolism of fatty acids regulates insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-434313</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330209</externalid>
        <name>ACSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343313</externalid>
        <name>ACSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9947021</externalid>
        <name>long-chain fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83139</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-434313</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400451</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381676</externalid>
    <name>Glucagon-like Peptide-1 (GLP1) regulates insulin secretion</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381676</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338236</externalid>
        <name>KCNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338232</externalid>
        <name>KCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320504</externalid>
        <name>ITPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336335</externalid>
        <name>GLP1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334112</externalid>
        <name>RAPGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381676</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422356</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163359</externalid>
    <name>Glucagon signaling in metabolic regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163359</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322990</externalid>
        <name>GCGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-164378</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-163359</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163685</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-164378</externalid>
    <name>PKA activation in glucagon signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-164378</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-164378</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163359</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163754</externalid>
    <name>Insulin effects increased synthesis of Xylulose-5-Phosphate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163754</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313952</externalid>
        <name>TALDO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313943</externalid>
        <name>TKT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z014</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5661242</externalid>
        <name>D-xylulose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925918</externalid>
        <name>sedoheptulose 7-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57483</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114814</externalid>
        <name>D-erythrose 4-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674788</externalid>
        <name>D-glyceraldehyde 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163754</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163685</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163680</externalid>
    <name>AMPK inhibits chREBP transcriptional activation activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163680</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10398403</externalid>
        <name>ADIPOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398391</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M564</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323007</externalid>
        <name>PRKAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398397</externalid>
        <name>ADIPOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163680</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163685</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202131</externalid>
    <name>Metabolism of nitric oxide: NOS3 activation and regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202131</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10331617</externalid>
        <name>ZDHHC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331624</externalid>
        <name>LYPLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342248</externalid>
        <name>CYB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356663</externalid>
        <name>SPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N453</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377983</externalid>
        <name>CYGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387196</externalid>
        <name>DDAH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56965</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331589</externalid>
        <name>NOSIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9035290</externalid>
        <name>nitrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911128</externalid>
        <name>dimethylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-203615</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-203754</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-203641</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-202131</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-203615</externalid>
    <name>eNOS activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-203615</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356663</externalid>
        <name>SPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N453</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377983</externalid>
        <name>CYGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387196</externalid>
        <name>DDAH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56965</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331617</externalid>
        <name>ZDHHC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331624</externalid>
        <name>LYPLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342248</externalid>
        <name>CYB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9035290</externalid>
        <name>nitrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911128</externalid>
        <name>dimethylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-203615</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202131</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-203754</externalid>
    <name>NOSIP mediated eNOS trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-203754</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331589</externalid>
        <name>NOSIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-203754</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202131</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-203641</externalid>
    <name>NOSTRIN mediated eNOS trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-203641</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-203641</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202131</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1428517</externalid>
    <name>Aerobic respiration and respiratory electron transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1428517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323129</externalid>
        <name>UQCRFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323113</externalid>
        <name>UQCRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386123</externalid>
        <name>NUBPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418543</externalid>
        <name>COX16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393242</externalid>
        <name>NDUFAF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418639</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5P2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313642</externalid>
        <name>SDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323160</externalid>
        <name>ATP5F1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05632</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418535</externalid>
        <name>COX19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418353</externalid>
        <name>GID8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313661</externalid>
        <name>SUCLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313636</externalid>
        <name>SDHD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>V6F7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322617</externalid>
        <name>NDUFA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01321</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355363</externalid>
        <name>ISCU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314153</externalid>
        <name>PKM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D984</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322947</externalid>
        <name>COQ10B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323218</externalid>
        <name>ATP5MK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322767</externalid>
        <name>ND5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q85BD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393305</externalid>
        <name>NDUFAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331777</externalid>
        <name>DLAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323555</externalid>
        <name>UCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322825</externalid>
        <name>NDUFA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P42029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313582</externalid>
        <name>ACO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322571</externalid>
        <name>COX7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A0N4STN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418477</externalid>
        <name>COX14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389832</externalid>
        <name>HSCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QGP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313567</externalid>
        <name>IDH3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77784</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322623</externalid>
        <name>COX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331784</externalid>
        <name>PDHX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22439</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418481</externalid>
        <name>SMIM20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322731</externalid>
        <name>NDUFS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02375</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314159</externalid>
        <name>PKLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854367</externalid>
        <name>(dioxido)oxidocarbonate(.1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316163</externalid>
        <name>(R)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16004</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9866133</externalid>
        <name>ferroheme c(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61717</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317283</externalid>
        <name>(S)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673061</externalid>
        <name>N-oleoyl-L-phenylalaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854364</externalid>
        <name>Fe3S4 iron-sulfur cluster</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879994</externalid>
        <name>4-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861588</externalid>
        <name>S-(alpha-chlorocarboxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>229639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9968566</externalid>
        <name>(R)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865436</externalid>
        <name>copper cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861590</externalid>
        <name>2''-O-lipoyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861970</externalid>
        <name>(R)-S-lactoylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-70268</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71403</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-611105</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163210</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166187</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-880009</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1428517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70268</externalid>
    <name>Pyruvate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70268</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10408785</externalid>
        <name>ME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376326</externalid>
        <name>VDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P45879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313163</externalid>
        <name>LDHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331757</externalid>
        <name>PDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331812</externalid>
        <name>PDK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408832</externalid>
        <name>ME3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408802</externalid>
        <name>ME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313178</externalid>
        <name>GPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418357</externalid>
        <name>MKLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408774</externalid>
        <name>FAHD1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RMND5A</name>
        <entity>
          <protein>
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              <externalid>E1BHI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GID8</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDHX</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LDHB</name>
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      <gene>
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        <name>PKLR</name>
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              <externalid>Q1JPG7</externalid>
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      </gene>
      <gene>
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        <name>ARMC8</name>
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              <externalid>Q2KI54</externalid>
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          </protein>
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      <gene>
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        <name>HAGH</name>
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              <externalid>Q3B7M2</externalid>
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          </protein>
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      <gene>
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        <name>RANBP9</name>
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          </protein>
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      <gene>
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        <name>SIRT4</name>
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      <gene>
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        <name>LDHA</name>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>UBC</name>
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          </protein>
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      </gene>
      <gene>
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        <name>RMND5B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35816</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NEK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDK4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QR49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDHA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PDK1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>WDR26</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2TBM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DLAT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387419</externalid>
        <name>GLO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332192</externalid>
        <name>PDP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1T9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313135</externalid>
        <name>PC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331761</externalid>
        <name>PDHA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10418367</externalid>
        <name>MAEA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10331804</externalid>
        <name>PDK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q200</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418347</externalid>
        <name>GID4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332178</externalid>
        <name>PDPR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4M3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10405332</externalid>
        <name>PGAM5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIE7</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861588</externalid>
        <name>S-(alpha-chlorocarboxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>229639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30341</externalid>
        <name>methylglyoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17158</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316163</externalid>
        <name>(R)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16004</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861590</externalid>
        <name>2''-O-lipoyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861970</externalid>
        <name>(R)-S-lactoylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9861559</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9861718</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-70268</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9861559</externalid>
    <name>PDH complex synthesizes acetyl-CoA from PYR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9861559</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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        <externalid>10331777</externalid>
        <name>DLAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331761</externalid>
        <name>PDHA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331757</externalid>
        <name>PDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331767</externalid>
        <name>PDHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331784</externalid>
        <name>PDHX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22439</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9861559</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70268</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9861718</externalid>
    <name>Regulation of pyruvate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10408785</externalid>
        <name>ME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331757</externalid>
        <name>PDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331812</externalid>
        <name>PDK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418357</externalid>
        <name>MKLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7A3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418371</externalid>
        <name>RMND5A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418353</externalid>
        <name>GID8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L52</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331784</externalid>
        <name>PDHX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22439</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391772</externalid>
        <name>ARMC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI54</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383349</externalid>
        <name>RANBP9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385370</externalid>
        <name>SIRT4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313145</externalid>
        <name>LDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19858</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PKM2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418375</externalid>
        <name>RMND5B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC67</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35816</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NEK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBM3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PDK4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331767</externalid>
        <name>PDHA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418361</externalid>
        <name>WDR26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331777</externalid>
        <name>DLAT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1T9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331761</externalid>
        <name>PDHA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418367</externalid>
        <name>MAEA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331804</externalid>
        <name>PDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q200</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418347</externalid>
        <name>GID4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0P9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10332178</externalid>
        <name>PDPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4M3</externalid>
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          </protein>
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      <gene>
        <externalid>10405332</externalid>
        <name>PGAM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIE7</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861588</externalid>
        <name>S-(alpha-chlorocarboxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>229639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861590</externalid>
        <name>2''-O-lipoyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-204174</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9861718</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70268</externalid>
        <linkedsystemtype>
          <superset />
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  <biosystem>
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        <name>PDP1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDK3</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>PDHB</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
            <xref>
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              <externalid>Q2T9Y3</externalid>
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      </gene>
      <gene>
        <externalid>10331784</externalid>
        <name>PDHX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22439</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331798</externalid>
        <name>PDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331777</externalid>
        <name>DLAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332192</externalid>
        <name>PDP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385370</externalid>
        <name>SIRT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331761</externalid>
        <name>PDHA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331804</externalid>
        <name>PDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q200</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332178</externalid>
        <name>PDPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4M3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861588</externalid>
        <name>S-(alpha-chlorocarboxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>229639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861590</externalid>
        <name>2''-O-lipoyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-204174</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9861718</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71403</externalid>
    <name>Citric acid cycle (TCA cycle)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71403</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313594</externalid>
        <name>CS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403282</externalid>
        <name>ISCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418017</externalid>
        <name>SDHAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P574</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417996</externalid>
        <name>SDHAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QGP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313642</externalid>
        <name>SDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313567</externalid>
        <name>IDH3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77784</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86283</externalid>
        <name>SDHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313657</externalid>
        <name>SUCLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313661</externalid>
        <name>SUCLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313636</externalid>
        <name>SDHD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>V6F7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313614</externalid>
        <name>FH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418013</externalid>
        <name>SDHAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8PU71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345342</externalid>
        <name>NNT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313623</externalid>
        <name>SDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349375</externalid>
        <name>NFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313650</externalid>
        <name>TRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355363</externalid>
        <name>ISCU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313563</externalid>
        <name>IDH3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355367</externalid>
        <name>LYRM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153365</externalid>
        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82908</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403286</externalid>
        <name>ISCA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417975</externalid>
        <name>CSKMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313571</externalid>
        <name>IDH3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313629</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M728</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313604</externalid>
        <name>MDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385394</externalid>
        <name>SIRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313582</externalid>
        <name>ACO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345351</externalid>
        <name>IDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q04467</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355371</externalid>
        <name>FXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314260</externalid>
        <name>SUCLG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317324</externalid>
        <name>itaconate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854367</externalid>
        <name>(dioxido)oxidocarbonate(.1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854364</externalid>
        <name>Fe3S4 iron-sulfur cluster</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879994</externalid>
        <name>4-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9853506</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9854311</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-71403</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9853506</externalid>
    <name>OGDH complex synthesizes succinyl-CoA from 2-OG</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9853506</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153365</externalid>
        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82908</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9853506</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71403</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9854311</externalid>
    <name>Maturation of TCA enzymes and regulation of TCA cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9854311</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313594</externalid>
        <name>CS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417975</externalid>
        <name>CSKMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403286</externalid>
        <name>ISCA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403282</externalid>
        <name>ISCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418017</externalid>
        <name>SDHAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P574</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417996</externalid>
        <name>SDHAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313629</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M728</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QGP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313642</externalid>
        <name>SDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385394</externalid>
        <name>SIRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86283</externalid>
        <name>SDHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313582</externalid>
        <name>ACO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345351</externalid>
        <name>IDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q04467</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313636</externalid>
        <name>SDHD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>V6F7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355371</externalid>
        <name>FXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418013</externalid>
        <name>SDHAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8PU71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313623</externalid>
        <name>SDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349375</externalid>
        <name>NFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355363</externalid>
        <name>ISCU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355367</externalid>
        <name>LYRM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>879994</externalid>
        <name>4-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854367</externalid>
        <name>(dioxido)oxidocarbonate(.1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854364</externalid>
        <name>Fe3S4 iron-sulfur cluster</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9854311</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71403</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-611105</externalid>
    <name>Respiratory electron transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-611105</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>LYRM7</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>P13272</externalid>
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      <gene>
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      <gene>
        <externalid>10386123</externalid>
        <name>NUBPL</name>
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      <gene>
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        <name>COX16</name>
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              <externalid>Q2NKS2</externalid>
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      <gene>
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      <gene>
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        <externalid>10418529</externalid>
        <name>COX11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322817</externalid>
        <name>NDUFA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322829</externalid>
        <name>NDUFAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322727</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393273</externalid>
        <name>NDUFAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418485</externalid>
        <name>SURF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418473</externalid>
        <name>COA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322667</externalid>
        <name>COX7A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T857</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322793</externalid>
        <name>TMEM186</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323089</externalid>
        <name>UQCRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322870</externalid>
        <name>NDUFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9866133</externalid>
        <name>ferroheme c(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61717</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9865436</externalid>
        <name>copper cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6799198</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9865881</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9864848</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9856872</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-611105</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-6799198</externalid>
    <name>Complex I biogenesis</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6799198</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>NDUFAF6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7YVD7</externalid>
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        <name>NUBPL</name>
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      <gene>
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      <gene>
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        <name>NDUFAF7</name>
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              <externalid>F1MJQ5</externalid>
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          </protein>
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      <gene>
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        <name>NDUFB1</name>
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              <externalid>Q24JZ0</externalid>
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          </protein>
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      <gene>
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        <name>NDUFA7</name>
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      <gene>
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        <name>NDUFS5</name>
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          <protein>
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              <externalid>Q02379</externalid>
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          </protein>
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      <gene>
        <externalid>10322771</externalid>
        <name>MT-ND6</name>
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              <externalid>P03924</externalid>
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          </protein>
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      <gene>
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        <name>NDUFS2</name>
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      <gene>
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              <externalid>A4FUH5</externalid>
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          </protein>
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      <gene>
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              <externalid>Q02370</externalid>
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          </protein>
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      <gene>
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        <name>NDUFA5</name>
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              <externalid>P23935</externalid>
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          </protein>
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      <gene>
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              <externalid>Q2HJI2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NDUFA11</name>
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              <externalid>Q8HXG6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10377474</externalid>
        <name>HSPA9</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCH0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NDUFA10</name>
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              <externalid>A0A3Q1LW79</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NDUFB5</name>
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              <externalid>Q02380</externalid>
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      <gene>
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        <name>NDUFV1</name>
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              <externalid>A0A3Q1MG52</externalid>
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      <gene>
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        <name>FOXRED1</name>
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              <externalid>A0A452DJZ0</externalid>
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          </protein>
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      <gene>
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        <name>PYURF</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N7B6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ACAD9</name>
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          <protein>
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              <externalid>A0A3Q1MP25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322767</externalid>
        <name>ND5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q85BD6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MT-ND3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P03898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDUFB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02365</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393305</externalid>
        <name>NDUFAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322882</externalid>
        <name>NDUFB11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322825</externalid>
        <name>NDUFA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P42029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322721</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0E1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322902</externalid>
        <name>NDUFA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P34943</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322779</externalid>
        <name>ND2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322866</externalid>
        <name>NDUFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02376</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322813</externalid>
        <name>NDUFA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02371</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322739</externalid>
        <name>NDUFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15690</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389832</externalid>
        <name>HSCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLK9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MGC127919</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV7</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>NDUFS4</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MT-ND4</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <linkedsystem>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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        <name>COX7C</name>
        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMIM20</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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        <name>COA1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>NDUFA4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q01321</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>LOC783202</name>
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          </protein>
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      <gene>
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        <name>COQ10B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>HIGD2A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>COX3</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
        </entity>
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      <gene>
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        <name>RIP5</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>COX7A2L</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>COQ10A</name>
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          </protein>
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      </gene>
      <gene>
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        <name>TIMM21</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SURF1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COX6C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>COX6B2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q6YFP9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>COX7A2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10418519</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QD94</externalid>
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          </protein>
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      <gene>
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        <name>COX15</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DG6</externalid>
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          </protein>
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      <gene>
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        <name>TMEM177</name>
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          </protein>
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      <gene>
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        <name>COX6A1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>SCO2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6H784</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MZQ1</externalid>
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          </protein>
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      <gene>
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        <name>CMC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM6</externalid>
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          </protein>
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        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
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      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
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      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
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      <smallmolecule>
        <externalid>9865436</externalid>
        <name>copper cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-9864848</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-611105</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q3T145</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P33097</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DK4</externalid>
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      <gene>
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          <protein>
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          <protein>
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              <externalid>A6QNM9</externalid>
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      <gene>
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          <externalid>29991</externalid>
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      <smallmolecule>
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        <name>L-glutamate(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
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      <smallmolecule>
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        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydron</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ATP5ME</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323218</externalid>
        <name>ATP5MK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBI7</externalid>
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          </protein>
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      <gene>
        <externalid>10323186</externalid>
        <name>MT-ATP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03929</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323178</externalid>
        <name>ATP5MF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28851</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323214</externalid>
        <name>ATP5MJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323160</externalid>
        <name>ATP5F1E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05632</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323208</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MFV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323182</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A0N4STN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323228</externalid>
        <name>DMAC2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22027</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323166</externalid>
        <name>MT-ATP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323224</externalid>
        <name>ATP5PO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13621</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323170</externalid>
        <name>ATP5PD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13620</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323202</externalid>
        <name>ATP5MC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32876</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323198</externalid>
        <name>ATP5MC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323194</externalid>
        <name>ATP5PB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13619</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323156</externalid>
        <name>ATP5F1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05630</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323148</externalid>
        <name>ATP5F1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323152</externalid>
        <name>ATP5F1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323190</externalid>
        <name>ATP5PF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02721</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323144</externalid>
        <name>ATP5F1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163210</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166187</externalid>
    <name>Mitochondrial Uncoupling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166187</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323551</externalid>
        <name>UCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10861</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323555</externalid>
        <name>UCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323567</externalid>
        <name>SLC25A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323559</externalid>
        <name>UCP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323563</externalid>
        <name>SLC25A27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BME0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360841</externalid>
        <name>SLC25A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412459</externalid>
        <name>PM20D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673061</externalid>
        <name>N-oleoyl-L-phenylalaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-167826</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9673163</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166187</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-167826</externalid>
    <name>The fatty acid cycling model</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-167826</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323551</externalid>
        <name>UCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10861</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323555</externalid>
        <name>UCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323567</externalid>
        <name>SLC25A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323559</externalid>
        <name>UCP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323563</externalid>
        <name>SLC25A27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BME0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2023029</externalid>
        <name>fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28868</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-167826</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166187</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9673163</externalid>
    <name>Oleoyl-phe metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9673163</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10412459</externalid>
        <name>PM20D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673061</externalid>
        <name>N-oleoyl-L-phenylalaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9673163</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166187</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-880009</externalid>
    <name>Interconversion of 2-oxoglutarate and 2-hydroxyglutarate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-880009</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347662</externalid>
        <name>L2HGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347646</externalid>
        <name>ADHFE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347653</externalid>
        <name>D2HGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>879994</externalid>
        <name>4-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9968566</externalid>
        <name>(R)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317283</externalid>
        <name>(S)-2-hydroxyglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16782</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-880009</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1428517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-15869</externalid>
    <name>Metabolism of nucleotides</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-15869</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316323</externalid>
        <name>DGUOK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368444</externalid>
        <name>NUDT16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318469</externalid>
        <name>NT5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319048</externalid>
        <name>AK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08166</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367525</externalid>
        <name>NUDT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365666</externalid>
        <name>ADAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319423</externalid>
        <name>RRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315583</externalid>
        <name>UCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII0</externalid>
            </xref>
          </protein>
        </entity>
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        </entity>
      </gene>
      <gene>
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        <name>GSR</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315477</externalid>
        <name>UMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T887</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316355</externalid>
        <name>ADA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316341</externalid>
        <name>HPRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6T4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318460</externalid>
        <name>NT5C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319417</externalid>
        <name>RRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319389</externalid>
        <name>ADSS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PJR4</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737143</externalid>
        <name>dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737145</externalid>
        <name>dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736388</externalid>
        <name>N-carbamoyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737142</externalid>
        <name>dTDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737587</externalid>
        <name>dITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731607</externalid>
        <name>O(6)-methyl-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731611</externalid>
        <name>N(6)-methyl-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731654</externalid>
        <name>methylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850553</externalid>
        <name>adenosine 5'-tetraphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731597</externalid>
        <name>O(6)-methyl-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29516</externalid>
        <name>polysulfur</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17909</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30939</externalid>
        <name>5,6-dihydrothymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27468</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866618</externalid>
        <name>2'-deoxyribonucleoside 5'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731627</externalid>
        <name>N(6)-methyl-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172872</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737734</externalid>
        <name>(R)-3-aminoisobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737454</externalid>
        <name>dUTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61555</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736398</externalid>
        <name>5-amino-1-(5-phosphonato-D-ribosyl)imidazolium-4-carboxylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737598</externalid>
        <name>uridine 2'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737138</externalid>
        <name>dCDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731241</externalid>
        <name>2-hydroxy-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737599</externalid>
        <name>3'-UMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31343</externalid>
        <name>pseudouridine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18116</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736389</externalid>
        <name>(S)-dihydroorotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731233</externalid>
        <name>8-oxo-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172871</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736397</externalid>
        <name>5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866402</externalid>
        <name>2'-deoxyribonucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73316</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731297</externalid>
        <name>8-oxo-GMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>145694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731224</externalid>
        <name>2-hydroxy-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731232</externalid>
        <name>2-oxo-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34415</externalid>
        <name>triphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737736</externalid>
        <name>3-ureidoisobutyrate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736309</externalid>
        <name>2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32673</externalid>
        <name>pseudouridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731243</externalid>
        <name>8-oxo-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731225</externalid>
        <name>8-oxo-dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736314</externalid>
        <name>5-phospho-beta-D-ribosylaminium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58681</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30074</externalid>
        <name>ubiquinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316798</externalid>
        <name>8-oxo-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731242</externalid>
        <name>2-oxo-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737732</externalid>
        <name>nucleoside 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736391</externalid>
        <name>orotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736417</externalid>
        <name>N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866398</externalid>
        <name>nucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731303</externalid>
        <name>8-oxo-dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114834</externalid>
        <name>5,6-dihydrouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15901</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737144</externalid>
        <name>dUDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737591</externalid>
        <name>2'-deoxyinosine 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737733</externalid>
        <name>N-carbamoyl-beta-alaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11892</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737462</externalid>
        <name>P(1),P(6)-bis(5'-adenosyl)hexaphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737590</externalid>
        <name>XTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734625</externalid>
        <name>SAICAR(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731301</externalid>
        <name>8-oxo-GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749390</externalid>
        <name>2'-deoxyuridine 3'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734629</externalid>
        <name>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731299</externalid>
        <name>8-oxo-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736311</externalid>
        <name>5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137981</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736393</externalid>
        <name>orotidine 5'-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57538</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736308</externalid>
        <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866580</externalid>
        <name>2'-deoxyribonucleoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737584</externalid>
        <name>ITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114830</externalid>
        <name>9H-xanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17712</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736307</externalid>
        <name>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8956320</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-499943</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956321</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956319</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-15869</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8956320</externalid>
    <name>Nucleotide biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8956320</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315983</externalid>
        <name>IMPDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315498</externalid>
        <name>CAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316009</externalid>
        <name>ADSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316037</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M913</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316030</externalid>
        <name>GART</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q59A32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315477</externalid>
        <name>UMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T887</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316018</externalid>
        <name>PAICS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319397</externalid>
        <name>ADSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315970</externalid>
        <name>GMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315489</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316050</externalid>
        <name>PPAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319389</externalid>
        <name>ADSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315997</externalid>
        <name>ATIC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30074</externalid>
        <name>ubiquinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736388</externalid>
        <name>N-carbamoyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734629</externalid>
        <name>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736391</externalid>
        <name>orotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736417</externalid>
        <name>N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736311</externalid>
        <name>5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137981</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736389</externalid>
        <name>(S)-dihydroorotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736397</externalid>
        <name>5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736393</externalid>
        <name>orotidine 5'-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57538</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29516</externalid>
        <name>polysulfur</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17909</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736308</externalid>
        <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736309</externalid>
        <name>2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736307</externalid>
        <name>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736398</externalid>
        <name>5-amino-1-(5-phosphonato-D-ribosyl)imidazolium-4-carboxylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734625</externalid>
        <name>SAICAR(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736314</externalid>
        <name>5-phospho-beta-D-ribosylaminium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58681</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-73817</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-500753</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8956320</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-15869</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73817</externalid>
    <name>Purine ribonucleoside monophosphate biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73817</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316037</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M913</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316030</externalid>
        <name>GART</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q59A32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315983</externalid>
        <name>IMPDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316018</externalid>
        <name>PAICS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319397</externalid>
        <name>ADSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315970</externalid>
        <name>GMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316009</externalid>
        <name>ADSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316050</externalid>
        <name>PPAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319389</externalid>
        <name>ADSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315997</externalid>
        <name>ATIC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674795</externalid>
        <name>beta-D-fructofuranose 1,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734629</externalid>
        <name>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736417</externalid>
        <name>N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736311</externalid>
        <name>5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>137981</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736397</externalid>
        <name>5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58467</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29516</externalid>
        <name>polysulfur</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17909</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736308</externalid>
        <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143788</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736309</externalid>
        <name>2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736307</externalid>
        <name>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>147286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736398</externalid>
        <name>5-amino-1-(5-phosphonato-D-ribosyl)imidazolium-4-carboxylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77657</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9734625</externalid>
        <name>SAICAR(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736314</externalid>
        <name>5-phospho-beta-D-ribosylaminium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58681</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73817</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956320</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-500753</externalid>
    <name>Pyrimidine biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-500753</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315477</externalid>
        <name>UMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T887</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315498</externalid>
        <name>CAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315489</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30074</externalid>
        <name>ubiquinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736388</externalid>
        <name>N-carbamoyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48417</externalid>
        <name>coenzyme Q10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736391</externalid>
        <name>orotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30839</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736389</externalid>
        <name>(S)-dihydroorotate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736393</externalid>
        <name>orotidine 5'-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57538</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-500753</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956320</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-499943</externalid>
    <name>Interconversion of nucleotide di- and triphosphates</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-499943</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319031</externalid>
        <name>AK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>103882</externalid>
        <name>TXNRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319048</externalid>
        <name>AK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08166</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319423</externalid>
        <name>RRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389895</externalid>
        <name>AK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395390</externalid>
        <name>NME3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315649</externalid>
        <name>CTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315468</externalid>
        <name>AK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315565</externalid>
        <name>DCTD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389902</externalid>
        <name>AK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319027</externalid>
        <name>AK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319021</externalid>
        <name>AK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315625</externalid>
        <name>DTYMK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319440</externalid>
        <name>RRM2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319410</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315963</externalid>
        <name>GUK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46195</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396996</externalid>
        <name>NUDT13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346372</externalid>
        <name>CTPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319035</externalid>
        <name>AK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315658</externalid>
        <name>DUT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314186</externalid>
        <name>GSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315464</externalid>
        <name>CMPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6T4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346210</externalid>
        <name>NME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319417</externalid>
        <name>RRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315592</externalid>
        <name>TYMS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346206</externalid>
        <name>NME1-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52175</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737145</externalid>
        <name>dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737143</externalid>
        <name>dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737142</externalid>
        <name>dTDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737138</externalid>
        <name>dCDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58593</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866398</externalid>
        <name>nucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850553</externalid>
        <name>adenosine 5'-tetraphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866402</externalid>
        <name>2'-deoxyribonucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73316</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737144</externalid>
        <name>dUDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737462</externalid>
        <name>P(1),P(6)-bis(5'-adenosyl)hexaphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737454</externalid>
        <name>dUTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61555</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-499943</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-15869</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8956321</externalid>
    <name>Nucleotide salvage</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8956321</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316323</externalid>
        <name>DGUOK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316409</externalid>
        <name>UPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318993</externalid>
        <name>UCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315616</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365666</externalid>
        <name>ADAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317905</externalid>
        <name>AMPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315583</externalid>
        <name>UCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316332</externalid>
        <name>APRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346560</externalid>
        <name>GMPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346554</externalid>
        <name>GMPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315601</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N245</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407030</externalid>
        <name>UCKL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318880</externalid>
        <name>BEAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316403</externalid>
        <name>UPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316355</externalid>
        <name>ADA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315574</externalid>
        <name>DCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316341</externalid>
        <name>HPRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389812</externalid>
        <name>PUDP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317911</externalid>
        <name>AMPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318532</externalid>
        <name>ADK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731654</externalid>
        <name>methylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31343</externalid>
        <name>pseudouridine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18116</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32673</externalid>
        <name>pseudouridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-74217</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73614</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8956321</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-15869</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74217</externalid>
    <name>Purine salvage</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74217</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316323</externalid>
        <name>DGUOK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365666</externalid>
        <name>ADAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317905</externalid>
        <name>AMPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316355</externalid>
        <name>ADA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315574</externalid>
        <name>DCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316332</externalid>
        <name>APRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316341</externalid>
        <name>HPRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317911</externalid>
        <name>AMPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318532</externalid>
        <name>ADK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346560</externalid>
        <name>GMPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346554</externalid>
        <name>GMPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731654</externalid>
        <name>methylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-74217</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956321</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73614</externalid>
    <name>Pyrimidine salvage</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73614</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315601</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N245</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407030</externalid>
        <name>UCKL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316409</externalid>
        <name>UPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318880</externalid>
        <name>BEAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318993</externalid>
        <name>UCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315616</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316403</externalid>
        <name>UPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315583</externalid>
        <name>UCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315574</externalid>
        <name>DCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389812</externalid>
        <name>PUDP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32673</externalid>
        <name>pseudouridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31343</externalid>
        <name>pseudouridine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18116</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73614</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956321</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8956319</externalid>
    <name>Nucleotide catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8956319</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368444</externalid>
        <name>NUDT16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316380</externalid>
        <name>NT5C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318469</externalid>
        <name>NT5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367525</externalid>
        <name>NUDT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315538</externalid>
        <name>DPYD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N549</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399010</externalid>
        <name>ENTPD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399001</externalid>
        <name>ENTPD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398985</externalid>
        <name>ENTPD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M496</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316403</externalid>
        <name>UPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318411</externalid>
        <name>NT5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398964</externalid>
        <name>ENTPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399041</externalid>
        <name>ENTPD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316391</externalid>
        <name>GDA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318453</externalid>
        <name>NT5C1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367489</externalid>
        <name>NUDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315556</externalid>
        <name>UPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367419</externalid>
        <name>NUDT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401227</externalid>
        <name>SAMHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316409</externalid>
        <name>UPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387866</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368456</externalid>
        <name>ITPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318442</externalid>
        <name>NT5C1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367410</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316371</externalid>
        <name>XDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398973</externalid>
        <name>ENTPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406900</externalid>
        <name>DNPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398895</externalid>
        <name>ENTPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399050</externalid>
        <name>ENTPD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315547</externalid>
        <name>DPYS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318480</externalid>
        <name>NT5M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318460</externalid>
        <name>NT5C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737142</externalid>
        <name>dTDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737587</externalid>
        <name>dITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731607</externalid>
        <name>O(6)-methyl-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731611</externalid>
        <name>N(6)-methyl-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731597</externalid>
        <name>O(6)-methyl-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30939</externalid>
        <name>5,6-dihydrothymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27468</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866618</externalid>
        <name>2'-deoxyribonucleoside 5'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731627</externalid>
        <name>N(6)-methyl-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172872</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737734</externalid>
        <name>(R)-3-aminoisobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737598</externalid>
        <name>uridine 2'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731241</externalid>
        <name>2-hydroxy-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737599</externalid>
        <name>3'-UMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731233</externalid>
        <name>8-oxo-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172871</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731297</externalid>
        <name>8-oxo-GMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>145694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731224</externalid>
        <name>2-hydroxy-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731232</externalid>
        <name>2-oxo-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34415</externalid>
        <name>triphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737736</externalid>
        <name>3-ureidoisobutyrate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731243</externalid>
        <name>8-oxo-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731225</externalid>
        <name>8-oxo-dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316798</externalid>
        <name>8-oxo-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731242</externalid>
        <name>2-oxo-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737732</externalid>
        <name>nucleoside 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866398</externalid>
        <name>nucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731303</externalid>
        <name>8-oxo-dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114834</externalid>
        <name>5,6-dihydrouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15901</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737591</externalid>
        <name>2'-deoxyinosine 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737733</externalid>
        <name>N-carbamoyl-beta-alaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11892</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737590</externalid>
        <name>XTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731301</externalid>
        <name>8-oxo-GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749390</externalid>
        <name>2'-deoxyuridine 3'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731299</externalid>
        <name>8-oxo-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866580</externalid>
        <name>2'-deoxyribonucleoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737584</externalid>
        <name>ITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114830</externalid>
        <name>9H-xanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17712</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-74259</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73621</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8850843</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8956319</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-15869</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74259</externalid>
    <name>Purine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74259</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368444</externalid>
        <name>NUDT16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316380</externalid>
        <name>NT5C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318469</externalid>
        <name>NT5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367419</externalid>
        <name>NUDT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387866</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367525</externalid>
        <name>NUDT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368456</externalid>
        <name>ITPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318442</externalid>
        <name>NT5C1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367410</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316371</externalid>
        <name>XDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406900</externalid>
        <name>DNPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318411</externalid>
        <name>NT5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316391</externalid>
        <name>GDA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318453</externalid>
        <name>NT5C1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367489</externalid>
        <name>NUDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114939</externalid>
        <name>2'-deoxyinosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316798</externalid>
        <name>8-oxo-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737504</externalid>
        <name>2-deoxy-D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62877</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731242</externalid>
        <name>2-oxo-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737587</externalid>
        <name>dITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731607</externalid>
        <name>O(6)-methyl-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731611</externalid>
        <name>N(6)-methyl-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731303</externalid>
        <name>8-oxo-dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731597</externalid>
        <name>O(6)-methyl-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731627</externalid>
        <name>N(6)-methyl-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172872</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737591</externalid>
        <name>2'-deoxyinosine 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735754</externalid>
        <name>2'-deoxyguanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737590</externalid>
        <name>XTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61314</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731301</externalid>
        <name>8-oxo-GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143554</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731299</externalid>
        <name>8-oxo-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731241</externalid>
        <name>2-hydroxy-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735749</externalid>
        <name>2'-deoxyadenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731233</externalid>
        <name>8-oxo-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172871</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731297</externalid>
        <name>8-oxo-GMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>145694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731224</externalid>
        <name>2-hydroxy-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731232</externalid>
        <name>2-oxo-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735750</externalid>
        <name>5'-xanthylate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737584</externalid>
        <name>ITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114830</externalid>
        <name>9H-xanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17712</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731243</externalid>
        <name>8-oxo-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731225</externalid>
        <name>8-oxo-dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71362</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2393930</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74259</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956319</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2393930</externalid>
    <name>Phosphate bond hydrolysis by NUDT proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2393930</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368444</externalid>
        <name>NUDT16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367419</externalid>
        <name>NUDT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387866</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367525</externalid>
        <name>NUDT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367410</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367489</externalid>
        <name>NUDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316798</externalid>
        <name>8-oxo-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731299</externalid>
        <name>8-oxo-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731242</externalid>
        <name>2-oxo-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731607</externalid>
        <name>O(6)-methyl-dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731663</externalid>
        <name>2'-deoxyinosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731241</externalid>
        <name>2-hydroxy-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77897</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731611</externalid>
        <name>N(6)-methyl-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172873</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731303</externalid>
        <name>8-oxo-dGDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731597</externalid>
        <name>O(6)-methyl-dGMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731233</externalid>
        <name>8-oxo-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172871</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731297</externalid>
        <name>8-oxo-GMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>145694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731224</externalid>
        <name>2-hydroxy-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731627</externalid>
        <name>N(6)-methyl-dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172872</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731232</externalid>
        <name>2-oxo-ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>172878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737591</externalid>
        <name>2'-deoxyinosine 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62286</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731606</externalid>
        <name>N(6)-methyl-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>169976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731625</externalid>
        <name>N(6)-methyl-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>144842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731243</externalid>
        <name>8-oxo-dAMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731225</externalid>
        <name>8-oxo-dADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731301</externalid>
        <name>8-oxo-GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>143554</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2393930</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74259</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73621</externalid>
    <name>Pyrimidine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73621</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315556</externalid>
        <name>UPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318469</externalid>
        <name>NT5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316409</externalid>
        <name>UPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316403</externalid>
        <name>UPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318411</externalid>
        <name>NT5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315547</externalid>
        <name>DPYS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318442</externalid>
        <name>NT5C1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318480</externalid>
        <name>NT5M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315538</externalid>
        <name>DPYD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N549</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318460</externalid>
        <name>NT5C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9749390</externalid>
        <name>2'-deoxyuridine 3'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737585</externalid>
        <name>2-deoxy-D-ribofuranose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58576</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30895</externalid>
        <name>2'-deoxycytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737599</externalid>
        <name>3'-UMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30939</externalid>
        <name>5,6-dihydrothymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27468</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114834</externalid>
        <name>5,6-dihydrouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15901</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737135</externalid>
        <name>dUMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>246422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737734</externalid>
        <name>(R)-3-aminoisobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737733</externalid>
        <name>N-carbamoyl-beta-alaninate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11892</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737736</externalid>
        <name>3-ureidoisobutyrate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>74414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30305</externalid>
        <name>2'-deoxyuridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737598</externalid>
        <name>uridine 2'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737141</externalid>
        <name>2'-deoxycytosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57566</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73621</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956319</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8850843</externalid>
    <name>Phosphate bond hydrolysis by NTPDase proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8850843</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10398985</externalid>
        <name>ENTPD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M496</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398895</externalid>
        <name>ENTPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399050</externalid>
        <name>ENTPD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398964</externalid>
        <name>ENTPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399041</externalid>
        <name>ENTPD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398973</externalid>
        <name>ENTPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399010</externalid>
        <name>ENTPD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399001</externalid>
        <name>ENTPD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737142</externalid>
        <name>dTDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737732</externalid>
        <name>nucleoside 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8866398</externalid>
        <name>nucleoside 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737146</externalid>
        <name>dTMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737586</externalid>
        <name>IDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737584</externalid>
        <name>ITP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8850843</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8956319</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196854</externalid>
    <name>Metabolism of vitamins and cofactors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196854</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10395344</externalid>
        <name>UBIAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328630</externalid>
        <name>PPCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393363</externalid>
        <name>BST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370414</externalid>
        <name>SLC52A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328726</externalid>
        <name>NMNAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370369</externalid>
        <name>MMADHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328930</externalid>
        <name>SLC2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328960</externalid>
        <name>SLC23A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407232</externalid>
        <name>RNLS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328681</externalid>
        <name>ACP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377000</externalid>
        <name>ABCD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395407</externalid>
        <name>NAXE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367666</externalid>
        <name>LRP12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349385</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328939</externalid>
        <name>CYB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00171</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330141</externalid>
        <name>MTHFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369983</externalid>
        <name>CBLIF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329726</externalid>
        <name>SLC5A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328765</externalid>
        <name>DHFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T872</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370400</externalid>
        <name>MMAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328926</externalid>
        <name>SLC2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27674</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395337</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367681</externalid>
        <name>TTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46375</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396053</externalid>
        <name>NUDT12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328758</externalid>
        <name>FPGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365927</externalid>
        <name>COQ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350839</externalid>
        <name>RBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313409</externalid>
        <name>MCCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114783</externalid>
        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15956</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162199</externalid>
        <name>3-demethylubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64182</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759439</externalid>
        <name>S-substituted glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90779</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33751</externalid>
        <name>cyanocob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395898</externalid>
        <name>5-methyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969925</externalid>
        <name>4-pyridoxate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37249</externalid>
        <name>menadione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947507</externalid>
        <name>precursor Z(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423740</externalid>
        <name>all-trans-decaprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760855</externalid>
        <name>riboflavin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960802</externalid>
        <name>biocytin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938248</externalid>
        <name>(S)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395209</externalid>
        <name>5,10-methenyltetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65049</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29828</externalid>
        <name>pyridoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760792</externalid>
        <name>N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947519</externalid>
        <name>Mo(VI)(=O)(=S)(OH)-molybdopterin cofactor(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60102</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327670</externalid>
        <name>10-formyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28010</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938240</externalid>
        <name>6-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34987</externalid>
        <name>dyspropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34053</externalid>
        <name>thiamine(1+) triphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30809</externalid>
        <name>pantetheine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1497812</externalid>
        <name>monodehydro-L-ascorbate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869380</externalid>
        <name>nicotinate D-ribonucleotide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162196</externalid>
        <name>2-decaprenyl-6-methoxy-3-methylhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30319</externalid>
        <name>pyridoxamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327960</externalid>
        <name>5,10-methylenetetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60473</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423440</externalid>
        <name>beta-ionone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878986</externalid>
        <name>deamido-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162216</externalid>
        <name>2-decaprenyl-6-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50774</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33265</externalid>
        <name>(R,R,R)-alpha-tocopherol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760793</externalid>
        <name>(R)-4'-phosphonatopantothenate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947564</externalid>
        <name>molybdate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30477</externalid>
        <name>pyridoxine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960380</externalid>
        <name>folate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162211</externalid>
        <name>4-hydroxy-3-all-trans-decaprenylbenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762303</externalid>
        <name>NMNH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90832</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760901</externalid>
        <name>7,8-dihydroneopterin 3'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654570</externalid>
        <name>quinolinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869375</externalid>
        <name>D-ribosylnicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162197</externalid>
        <name>2-decaprenyl-6-methoxyhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760916</externalid>
        <name>pyridoxal 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>597326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30331</externalid>
        <name>cob(II)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869369</externalid>
        <name>NMN(-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162202</externalid>
        <name>3-decaprenyl-4,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9856696</externalid>
        <name>(S)-4-hydroxymandelate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947574</externalid>
        <name>molybdopterin(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316198</externalid>
        <name>D-pantetheine 4'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29944</externalid>
        <name>pyridoxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16709</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837339</externalid>
        <name>3'-dephospho-CoA(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57328</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9758891</externalid>
        <name>corrinoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33913</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30052</externalid>
        <name>thiamine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938242</externalid>
        <name>(R)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64075</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760745</externalid>
        <name>(6R)-5,10-methenyltetrahydrofolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30511</externalid>
        <name>pyridoxamine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34775</externalid>
        <name>tetrahydrofolyl-poly(glutamic acid) macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162217</externalid>
        <name>3-decaprenyl-4-hydroxy-5-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29650</externalid>
        <name>4-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938244</externalid>
        <name>2-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88138</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806667</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978934</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-196854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196849</externalid>
    <name>Metabolism of water-soluble vitamins and cofactors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196849</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328630</externalid>
        <name>PPCS</name>
        <entity>
          <protein>
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        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
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      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
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      <smallmolecule>
        <externalid>9759439</externalid>
        <name>S-substituted glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90779</externalid>
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      <smallmolecule>
        <externalid>33751</externalid>
        <name>cyanocob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
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      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2395898</externalid>
        <name>5-methyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63907</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9969925</externalid>
        <name>4-pyridoxate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
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      <smallmolecule>
        <externalid>947507</externalid>
        <name>precursor Z(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59648</externalid>
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      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
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      <smallmolecule>
        <externalid>9760855</externalid>
        <name>riboflavin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57986</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
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      <smallmolecule>
        <externalid>9960802</externalid>
        <name>biocytin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195545</externalid>
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      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      <smallmolecule>
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        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
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      <smallmolecule>
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        <name>(S)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64074</externalid>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
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      <smallmolecule>
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        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
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      <smallmolecule>
        <externalid>2395209</externalid>
        <name>5,10-methenyltetrahydrofolate polyglutamate macromolecule</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>65049</externalid>
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      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29828</externalid>
        <name>pyridoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
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      <smallmolecule>
        <externalid>9760792</externalid>
        <name>N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947519</externalid>
        <name>Mo(VI)(=O)(=S)(OH)-molybdopterin cofactor(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60102</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2327670</externalid>
        <name>10-formyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28010</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9938240</externalid>
        <name>6-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88140</externalid>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      <smallmolecule>
        <externalid>34053</externalid>
        <name>thiamine(1+) triphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9534</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30809</externalid>
        <name>pantetheine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16753</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1497812</externalid>
        <name>monodehydro-L-ascorbate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869380</externalid>
        <name>nicotinate D-ribonucleotide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30319</externalid>
        <name>pyridoxamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327960</externalid>
        <name>5,10-methylenetetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60473</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878986</externalid>
        <name>deamido-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760793</externalid>
        <name>(R)-4'-phosphonatopantothenate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947564</externalid>
        <name>molybdate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30477</externalid>
        <name>pyridoxine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960380</externalid>
        <name>folate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762303</externalid>
        <name>NMNH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90832</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654570</externalid>
        <name>quinolinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869375</externalid>
        <name>D-ribosylnicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760916</externalid>
        <name>pyridoxal 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>597326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30331</externalid>
        <name>cob(II)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869369</externalid>
        <name>NMN(-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947574</externalid>
        <name>molybdopterin(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316198</externalid>
        <name>D-pantetheine 4'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29944</externalid>
        <name>pyridoxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16709</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837339</externalid>
        <name>3'-dephospho-CoA(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57328</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9758891</externalid>
        <name>corrinoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33913</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30052</externalid>
        <name>thiamine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938242</externalid>
        <name>(R)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64075</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760745</externalid>
        <name>(6R)-5,10-methenyltetrahydrofolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30511</externalid>
        <name>pyridoxamine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34775</externalid>
        <name>tetrahydrofolyl-poly(glutamic acid) macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938244</externalid>
        <name>2-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88138</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-196836</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196819</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196843</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199220</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-964975</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196741</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196780</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196807</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196757</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-947581</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-196849</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196836</externalid>
    <name>Vitamin C (ascorbate) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196836</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325629</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328964</externalid>
        <name>SLC23A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328939</externalid>
        <name>CYB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00171</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325635</externalid>
        <name>GSTO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BED9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328930</externalid>
        <name>SLC2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328960</externalid>
        <name>SLC23A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328947</externalid>
        <name>CYB5R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328926</externalid>
        <name>SLC2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27674</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1497812</externalid>
        <name>monodehydro-L-ascorbate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196836</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196819</externalid>
    <name>Vitamin B1 (thiamin) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196819</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349486</externalid>
        <name>THTPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8MKF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328646</externalid>
        <name>TPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9T4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329873</externalid>
        <name>SLC19A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E352</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329869</externalid>
        <name>SLC19A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402703</externalid>
        <name>SLC25A19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>34053</externalid>
        <name>thiamine(1+) triphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9534</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30052</externalid>
        <name>thiamine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196819</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196843</externalid>
    <name>Vitamin B2 (riboflavin) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196843</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328674</externalid>
        <name>FLAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R6Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370414</externalid>
        <name>SLC52A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328690</externalid>
        <name>ENPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328681</externalid>
        <name>ACP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370420</externalid>
        <name>SLC52A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328699</externalid>
        <name>RFK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760855</externalid>
        <name>riboflavin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196843</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-199220</externalid>
    <name>Vitamin B5 (pantothenate) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-199220</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328630</externalid>
        <name>PPCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416908</externalid>
        <name>SLC25A42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391192</externalid>
        <name>VNN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T891</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329722</externalid>
        <name>PDZD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403883</externalid>
        <name>VNN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328639</externalid>
        <name>COASY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317429</externalid>
        <name>FASN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N647</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329735</externalid>
        <name>SLC25A16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329702</externalid>
        <name>AASDHPPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LL63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328667</externalid>
        <name>PANK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329713</externalid>
        <name>PANK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416922</externalid>
        <name>PANK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416915</externalid>
        <name>DCAKD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328658</externalid>
        <name>PPCDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329726</externalid>
        <name>SLC5A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329709</externalid>
        <name>PANK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316198</externalid>
        <name>D-pantetheine 4'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30809</externalid>
        <name>pantetheine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837339</externalid>
        <name>3'-dephospho-CoA(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57328</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760792</externalid>
        <name>N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760793</externalid>
        <name>(R)-4'-phosphonatopantothenate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-196783</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-199220</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196783</externalid>
    <name>Coenzyme A biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196783</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328630</externalid>
        <name>PPCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416915</externalid>
        <name>DCAKD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328658</externalid>
        <name>PPCDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328639</externalid>
        <name>COASY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328667</externalid>
        <name>PANK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329713</externalid>
        <name>PANK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329709</externalid>
        <name>PANK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316198</externalid>
        <name>D-pantetheine 4'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837339</externalid>
        <name>3'-dephospho-CoA(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57328</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760792</externalid>
        <name>N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760793</externalid>
        <name>(R)-4'-phosphonatopantothenate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196783</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199220</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-964975</externalid>
    <name>Vitamin B6 activation to pyridoxal phosphate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-964975</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10370435</externalid>
        <name>AOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349464</externalid>
        <name>PDXK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349477</externalid>
        <name>PNPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29944</externalid>
        <name>pyridoxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16709</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760916</externalid>
        <name>pyridoxal 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>597326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30319</externalid>
        <name>pyridoxamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30511</externalid>
        <name>pyridoxamine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29828</externalid>
        <name>pyridoxal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969925</externalid>
        <name>4-pyridoxate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30477</externalid>
        <name>pyridoxine 5'-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28803</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-964975</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196741</externalid>
    <name>Cobalamin (Cbl, vitamin B12) transport and metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196741</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356460</externalid>
        <name>PRSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370369</externalid>
        <name>MMADHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377004</externalid>
        <name>LMBRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N364</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313678</externalid>
        <name>MUT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369974</externalid>
        <name>TCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377000</externalid>
        <name>ABCD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370153</externalid>
        <name>MMACHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357998</externalid>
        <name>CTRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332580</externalid>
        <name>CUBN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370396</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334341</externalid>
        <name>LRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369983</externalid>
        <name>CBLIF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333852</externalid>
        <name>AMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325223</externalid>
        <name>MTRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370291</externalid>
        <name>TCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370400</externalid>
        <name>MMAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313672</externalid>
        <name>MMAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33751</externalid>
        <name>cyanocob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759439</externalid>
        <name>S-substituted glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90779</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30331</externalid>
        <name>cob(II)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9758891</externalid>
        <name>corrinoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33913</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9758881</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9758890</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9759218</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-196741</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9758881</externalid>
    <name>Uptake of dietary cobalamins into enterocytes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9758881</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357998</externalid>
        <name>CTRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332580</externalid>
        <name>CUBN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356460</externalid>
        <name>PRSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377004</externalid>
        <name>LMBRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N364</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369983</externalid>
        <name>CBLIF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370291</externalid>
        <name>TCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333852</externalid>
        <name>AMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377000</externalid>
        <name>ABCD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9758881</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196741</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9758890</externalid>
    <name>Transport of RCbl within the body</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9758890</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10369994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334341</externalid>
        <name>LRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377004</externalid>
        <name>LMBRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N364</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370291</externalid>
        <name>TCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369974</externalid>
        <name>TCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377000</externalid>
        <name>ABCD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9758891</externalid>
        <name>corrinoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33913</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9758890</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196741</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9759218</externalid>
    <name>Cobalamin (Cbl) metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9759218</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10370396</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370369</externalid>
        <name>MMADHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325223</externalid>
        <name>MTRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313678</externalid>
        <name>MUT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370400</externalid>
        <name>MMAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370153</externalid>
        <name>MMACHC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313672</externalid>
        <name>MMAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30331</externalid>
        <name>cob(II)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33751</externalid>
        <name>cyanocob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759439</externalid>
        <name>S-substituted glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90779</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759388</externalid>
        <name>R-cob(III)alamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>140785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114804</externalid>
        <name>cobamamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9759218</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196741</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196780</externalid>
    <name>Biotin transport and metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196780</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10329722</externalid>
        <name>PDZD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370146</externalid>
        <name>BTD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313135</externalid>
        <name>PC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330092</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329726</externalid>
        <name>SLC5A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313700</externalid>
        <name>PCCA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313413</externalid>
        <name>MCCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313409</externalid>
        <name>MCCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317380</externalid>
        <name>ACACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369751</externalid>
        <name>HLCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114783</externalid>
        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15956</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960802</externalid>
        <name>biocytin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196780</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196807</externalid>
    <name>Nicotinate metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196807</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330129</externalid>
        <name>NMNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393363</externalid>
        <name>BST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328726</externalid>
        <name>NMNAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401721</externalid>
        <name>NMRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396053</externalid>
        <name>NUDT12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328735</externalid>
        <name>NAMPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M241</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325564</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407232</externalid>
        <name>RNLS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328749</externalid>
        <name>NADSYN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420050</externalid>
        <name>MCART1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395407</externalid>
        <name>NAXE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401728</externalid>
        <name>NMRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318411</externalid>
        <name>NT5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342591</externalid>
        <name>SMCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C8KIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403856</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NCV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407070</externalid>
        <name>NADK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328742</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395416</externalid>
        <name>NAXD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8878986</externalid>
        <name>deamido-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869369</externalid>
        <name>NMN(-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14649</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938240</externalid>
        <name>6-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88140</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8870341</externalid>
        <name>ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57967</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762303</externalid>
        <name>NMNH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90832</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869380</externalid>
        <name>nicotinate D-ribonucleotide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938242</externalid>
        <name>(R)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64075</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654570</externalid>
        <name>quinolinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938248</externalid>
        <name>(S)-NADHX(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869375</externalid>
        <name>D-ribosylnicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9938244</externalid>
        <name>2-hydro-beta-NAD(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88138</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196807</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196757</externalid>
    <name>Metabolism of folate and pterines</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196757</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10394483</externalid>
        <name>MTHFD2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313863</externalid>
        <name>SHMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328758</externalid>
        <name>FPGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395813</externalid>
        <name>ALDH1L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391752</externalid>
        <name>FOLR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394479</externalid>
        <name>MTHFD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395823</externalid>
        <name>ALDH1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394492</externalid>
        <name>MTHFS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330141</externalid>
        <name>MTHFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330159</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387455</externalid>
        <name>SHMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330178</externalid>
        <name>SLC25A32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328765</externalid>
        <name>DHFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T872</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330169</externalid>
        <name>MTHFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NGK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330150</externalid>
        <name>SLC46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388269</externalid>
        <name>MTHFD1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395209</externalid>
        <name>5,10-methenyltetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65049</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395898</externalid>
        <name>5-methyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327670</externalid>
        <name>10-formyltetrahydrofolyl polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28010</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960380</externalid>
        <name>folate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759622</externalid>
        <name>(6S)-5-methyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760745</externalid>
        <name>(6R)-5,10-methenyltetrahydrofolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737456</externalid>
        <name>dihydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736310</externalid>
        <name>10-formyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34775</externalid>
        <name>tetrahydrofolyl-poly(glutamic acid) macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327960</externalid>
        <name>5,10-methylenetetrahydrofolate polyglutamate macromolecule</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60473</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196757</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-947581</externalid>
    <name>Molybdenum cofactor biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-947581</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349385</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349375</externalid>
        <name>NFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349364</externalid>
        <name>MOCS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349396</externalid>
        <name>MOCS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349356</externalid>
        <name>MOCOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N0E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947507</externalid>
        <name>precursor Z(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947519</externalid>
        <name>Mo(VI)(=O)(=S)(OH)-molybdopterin cofactor(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60102</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947564</externalid>
        <name>molybdate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36264</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>947574</externalid>
        <name>molybdopterin(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937150</externalid>
        <name>tetra-mu3-sulfido-tetrairon(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33722</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-947581</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196849</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6806667</externalid>
    <name>Metabolism of fat-soluble vitamins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6806667</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10395344</externalid>
        <name>UBIAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367666</externalid>
        <name>LRP12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334341</externalid>
        <name>LRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325523</externalid>
        <name>LPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11151</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367681</externalid>
        <name>TTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46375</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395337</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367662</externalid>
        <name>LRP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350839</externalid>
        <name>RBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359191</externalid>
        <name>GPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322240</externalid>
        <name>VKORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6B4J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327772</externalid>
        <name>CLPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359226</externalid>
        <name>SDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402455</externalid>
        <name>TTPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N086</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359201</externalid>
        <name>GPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375942</externalid>
        <name>BCO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Z9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342294</externalid>
        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359183</externalid>
        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343001</externalid>
        <name>LRP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377320</externalid>
        <name>APOM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316751</externalid>
        <name>LOC101906939</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LU75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367675</externalid>
        <name>RBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350845</externalid>
        <name>LRAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316755</externalid>
        <name>RBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350832</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369524</externalid>
        <name>AKR1B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N678</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316777</externalid>
        <name>RDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325519</externalid>
        <name>GPIHBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366208</externalid>
        <name>LRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350860</externalid>
        <name>BCO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1423440</externalid>
        <name>beta-ionone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33265</externalid>
        <name>(R,R,R)-alpha-tocopherol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37249</externalid>
        <name>menadione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6806664</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975634</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8877627</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6806667</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6806664</externalid>
    <name>Metabolism of vitamin K</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6806664</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10395344</externalid>
        <name>UBIAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395337</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322240</externalid>
        <name>VKORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6B4J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37249</externalid>
        <name>menadione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6806664</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806667</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975634</externalid>
    <name>Retinoid metabolism and transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975634</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359211</externalid>
        <name>SDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367666</externalid>
        <name>LRP12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN03</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334341</externalid>
        <name>LRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SDC2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11151</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367681</externalid>
        <name>TTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46375</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LRP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPB1</externalid>
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      <gene>
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        <name>RBP2</name>
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              <externalid>A7MBG1</externalid>
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          </protein>
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      <gene>
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        <name>GPC2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKJ2</externalid>
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      <gene>
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        <name>CLPS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0JNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SDC4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKS1</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MCX1</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <externalid>F1MK69</externalid>
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          </protein>
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      <gene>
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        <name>BCO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Z9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ29</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AGRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTY7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343001</externalid>
        <name>LRP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377320</externalid>
        <name>APOM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316751</externalid>
        <name>LOC101906939</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LU75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367675</externalid>
        <name>RBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359196</externalid>
        <name>GPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350845</externalid>
        <name>LRAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316755</externalid>
        <name>RBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350832</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369524</externalid>
        <name>AKR1B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N678</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316777</externalid>
        <name>RDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325519</externalid>
        <name>GPIHBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366208</externalid>
        <name>LRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350860</externalid>
        <name>BCO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1423440</externalid>
        <name>beta-ionone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-975634</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187338</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806667</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8877627</externalid>
    <name>Vitamin E transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8877627</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10402455</externalid>
        <name>TTPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N086</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>33265</externalid>
        <name>(R,R,R)-alpha-tocopherol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18145</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8877627</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806667</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8978934</externalid>
    <name>Metabolism of cofactors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8978934</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365899</externalid>
        <name>COQ3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365927</externalid>
        <name>COQ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356436</externalid>
        <name>GCHFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356450</externalid>
        <name>PTS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365941</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LK03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365955</externalid>
        <name>COQ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340622</externalid>
        <name>PRKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365989</externalid>
        <name>PDSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339069</externalid>
        <name>IDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418077</externalid>
        <name>HPDL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365903</externalid>
        <name>COQ5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356663</externalid>
        <name>SPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N453</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365937</externalid>
        <name>COQ8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365907</externalid>
        <name>COQ6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386712</externalid>
        <name>ACO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356427</externalid>
        <name>GCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418065</externalid>
        <name>STARD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365919</externalid>
        <name>COQ9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365913</externalid>
        <name>COQ7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365983</externalid>
        <name>PDSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162199</externalid>
        <name>3-demethylubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64182</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162197</externalid>
        <name>2-decaprenyl-6-methoxyhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162216</externalid>
        <name>2-decaprenyl-6-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50774</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162202</externalid>
        <name>3-decaprenyl-4,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9856696</externalid>
        <name>(S)-4-hydroxymandelate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34987</externalid>
        <name>dyspropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162211</externalid>
        <name>4-hydroxy-3-all-trans-decaprenylbenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760901</externalid>
        <name>7,8-dihydroneopterin 3'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162196</externalid>
        <name>2-decaprenyl-6-methoxy-3-methylhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423740</externalid>
        <name>all-trans-decaprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162217</externalid>
        <name>3-decaprenyl-4-hydroxy-5-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29650</externalid>
        <name>4-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17879</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2142789</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389542</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474151</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8978934</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-196854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2142789</externalid>
    <name>Ubiquinol biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2142789</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365899</externalid>
        <name>COQ3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365927</externalid>
        <name>COQ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365941</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LK03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365955</externalid>
        <name>COQ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365989</externalid>
        <name>PDSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418077</externalid>
        <name>HPDL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365903</externalid>
        <name>COQ5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365937</externalid>
        <name>COQ8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365907</externalid>
        <name>COQ6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418065</externalid>
        <name>STARD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365919</externalid>
        <name>COQ9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365913</externalid>
        <name>COQ7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365983</externalid>
        <name>PDSS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162199</externalid>
        <name>3-demethylubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64182</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162197</externalid>
        <name>2-decaprenyl-6-methoxyhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162201</externalid>
        <name>ubiquinol-10</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64183</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162216</externalid>
        <name>2-decaprenyl-6-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50774</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162202</externalid>
        <name>3-decaprenyl-4,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9856696</externalid>
        <name>(S)-4-hydroxymandelate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162211</externalid>
        <name>4-hydroxy-3-all-trans-decaprenylbenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84503</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162196</externalid>
        <name>2-decaprenyl-6-methoxy-3-methylhydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423740</externalid>
        <name>all-trans-decaprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162217</externalid>
        <name>3-decaprenyl-4-hydroxy-5-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29650</externalid>
        <name>4-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17879</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2142789</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-389542</externalid>
    <name>NADPH regeneration</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-389542</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10386712</externalid>
        <name>ACO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339069</externalid>
        <name>IDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5317351</externalid>
        <name>D-threo-isocitrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-389542</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1474151</externalid>
    <name>Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1474151</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356663</externalid>
        <name>SPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N453</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356436</externalid>
        <name>GCHFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356450</externalid>
        <name>PTS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340622</externalid>
        <name>PRKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356427</externalid>
        <name>GCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1475055</externalid>
        <name>triphosphate ion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760901</externalid>
        <name>7,8-dihydroneopterin 3'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911157</externalid>
        <name>L-erythro-7,8-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971694</externalid>
        <name>L-sepiapterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34987</externalid>
        <name>dyspropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17804</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1474151</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8978934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71291</externalid>
    <name>Metabolism of amino acids and derivatives</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71291</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387352</externalid>
        <name>FOLH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388258</externalid>
        <name>BHMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396901</externalid>
        <name>DDO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313370</externalid>
        <name>ODC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27117</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409293</externalid>
        <name>SDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313361</externalid>
        <name>ALDH4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313343</externalid>
        <name>PYCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365559</externalid>
        <name>IL4I1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332743</externalid>
        <name>SLC5A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385406</externalid>
        <name>SIRT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBQ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351099</externalid>
        <name>PSAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313902</externalid>
        <name>GAMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387139</externalid>
        <name>DBT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358816</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313873</externalid>
        <name>ALDH9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358831</externalid>
        <name>SQOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>103882</externalid>
        <name>TXNRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313893</externalid>
        <name>GATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334382</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313808</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334447</externalid>
        <name>DIO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354324</externalid>
        <name>ADI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313324</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1S4</externalid>
            </xref>
          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>3-phosphonato-D-glycerate(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9929651</externalid>
        <name>L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5693766</externalid>
        <name>Ac-Asp-Glu(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>(R)-adrenaline(1+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114898</externalid>
        <name>(S)-1-pyrroline-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
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      <smallmolecule>
        <externalid>37509</externalid>
        <name>5,6-dihydroxyindole</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9760787</externalid>
        <name>trioxidosulfanidosulfate(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>L-pipecolic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61185</externalid>
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      <smallmolecule>
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        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>L-cystathionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>glycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29805</externalid>
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      <smallmolecule>
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        <name>formate</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>iron(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>58769</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114851</externalid>
        <name>guanidinoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917130</externalid>
        <name>trans-3-methylglutaconyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925933</externalid>
        <name>N-formimidoyl-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31143</externalid>
        <name>N-acetyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760753</externalid>
        <name>S-adenosylmethioninaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929693</externalid>
        <name>S-methyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38065</externalid>
        <name>erythro-4-hydroxy-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760812</externalid>
        <name>3-sulfino-L-alanine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925991</externalid>
        <name>L-saccharopinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57951</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942548</externalid>
        <name>L-dopachromate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930611</externalid>
        <name>1,4-benzoquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33327</externalid>
        <name>3-iodo-L-tyrosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925788</externalid>
        <name>2-oxoglutaramate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760898</externalid>
        <name>anserine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929219</externalid>
        <name>(6R)-L-erythro-6,7-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>584170</externalid>
        <name>homogentisate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917117</externalid>
        <name>methacrylyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925787</externalid>
        <name>L-cysteate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58090</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930571</externalid>
        <name>L-selenocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29568</externalid>
        <name>pyrroloquinoline quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760863</externalid>
        <name>L-2-aminoadipate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58672</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9794619</externalid>
        <name>(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>141499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930607</externalid>
        <name>hydroquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925998</externalid>
        <name>erythro-5-phosphonatoooxy-L-lysinium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48605</externalid>
        <name>hydrogensulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760906</externalid>
        <name>5-hydroxy-L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31683</externalid>
        <name>diiodine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29794</externalid>
        <name>4-methyl-2-oxopentanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31045</externalid>
        <name>N-acetylserotonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760851</externalid>
        <name>hypotaurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925932</externalid>
        <name>5-formimidoyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423724</externalid>
        <name>keto-phenylpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18005</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930117</externalid>
        <name>3-mercaptopyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57678</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114875</externalid>
        <name>4-(trimethylammonio)butanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16244</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316215</externalid>
        <name>3-phosphonatooxypyruvate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9858329</externalid>
        <name>2-oxoadipate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942552</externalid>
        <name>L-dopaquinone zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939575</externalid>
        <name>(R)-indole-3-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573400</externalid>
        <name>4-fumarylacetoacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760912</externalid>
        <name>L-allysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58321</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937158</externalid>
        <name>sulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9794601</externalid>
        <name>N(6),N(6),N(6)-trimethyl-L-lysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58100</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30391</externalid>
        <name>betaine aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15710</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929650</externalid>
        <name>3-hydroxyanthranilate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36559</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357689</externalid>
        <name>methylselenenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929683</externalid>
        <name>4-(2-aminophenyl)-2,4-dioxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58147</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317429</externalid>
        <name>(S)-3-hydroxyisobutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762309</externalid>
        <name>sarcosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930578</externalid>
        <name>L-adenosylselenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942549</externalid>
        <name>indole-5,6-quinone-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>177869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760852</externalid>
        <name>creatine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929647</externalid>
        <name>3-hydroxy-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925950</externalid>
        <name>3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77893</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237127</externalid>
        <name>4-methylthio-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929929</externalid>
        <name>L-lanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693979</externalid>
        <name>N(6)-dihydrolipoyl-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760845</externalid>
        <name>N-phosphocreatinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917132</externalid>
        <name>2-methylcrotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57337</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316197</externalid>
        <name>1,2-dihydroxy-5-(methylthio)pent-1-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693964</externalid>
        <name>N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760754</externalid>
        <name>(N(omega)-L-arginino)succinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57472</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762228</externalid>
        <name>3,5-diiodo-L-tyrosinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57506</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930580</externalid>
        <name>selanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29317</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784232</externalid>
        <name>4-hydroxy-2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17742</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929454</externalid>
        <name>O-phosphonato-L-serine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317514</externalid>
        <name>(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917114</externalid>
        <name>(S)-3-hydroxyisobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62611</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929635</externalid>
        <name>N-formyl-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114872</externalid>
        <name>4-trimethylammoniobutanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316161</externalid>
        <name>3-methyl-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930123</externalid>
        <name>disulfanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929690</externalid>
        <name>cis,cis-2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859161</externalid>
        <name>(R)-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>156439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762301</externalid>
        <name>5,6-dihydroxyindole-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925990</externalid>
        <name>erythro-5-hydroxy-L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58357</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955516</externalid>
        <name>2''-O-glutaryl-ADP-D-ribose(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760847</externalid>
        <name>L-glutamic 5-semialdehyde zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760761</externalid>
        <name>glutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114869</externalid>
        <name>4-maleylacetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237170</externalid>
        <name>S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357682</externalid>
        <name>methylselenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64685</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929618</externalid>
        <name>2-iminobutanoic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237131</externalid>
        <name>5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930579</externalid>
        <name>L-selenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114852</externalid>
        <name>N-acetyl-L-glutamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237088</externalid>
        <name>S-methyl-5-thio-D-ribulose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925938</externalid>
        <name>trans-urocanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17771</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760744</externalid>
        <name>isovaleryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317402</externalid>
        <name>(S)-3-methyl-2-oxovalerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939574</externalid>
        <name>3-(1H-indol-3-yl)propanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925986</externalid>
        <name>1-piperideine-2-carboxylic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760749</externalid>
        <name>3-methylbut-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929922</externalid>
        <name>L-homolanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760756</externalid>
        <name>carnosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861965</externalid>
        <name>glyoxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357668</externalid>
        <name>methylseleninic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917133</externalid>
        <name>(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57312</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930121</externalid>
        <name>S-sulfanylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859158</externalid>
        <name>isobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622408</externalid>
        <name>hydrogen iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8963693</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964539</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964540</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70895</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70921</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71064</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963691</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70688</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-977347</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8849175</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71240</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614635</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2408522</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389661</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70635</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71262</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71288</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6798163</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351202</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5662702</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209776</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-71291</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963693</externalid>
    <name>Aspartate and asparagine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963693</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313250</externalid>
        <name>GOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389785</externalid>
        <name>GADL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386946</externalid>
        <name>ASPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334834</externalid>
        <name>SLC25A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387352</externalid>
        <name>FOLH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334828</externalid>
        <name>SLC25A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313281</externalid>
        <name>ASNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387358</externalid>
        <name>NAALAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313271</externalid>
        <name>GOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12344</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390860</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MM30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760851</externalid>
        <name>hypotaurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925787</externalid>
        <name>L-cysteate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58090</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760812</externalid>
        <name>3-sulfino-L-alanine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31143</externalid>
        <name>N-acetyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693766</externalid>
        <name>Ac-Asp-Glu(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963693</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964539</externalid>
    <name>Glutamate and glutamine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964539</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10389092</externalid>
        <name>PYCR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404962</externalid>
        <name>RIMKLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389083</externalid>
        <name>PYCR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346461</externalid>
        <name>ALDH18A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404958</externalid>
        <name>RIMKLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313343</externalid>
        <name>PYCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313260</externalid>
        <name>GLUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313292</externalid>
        <name>GLUL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313271</externalid>
        <name>GOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12344</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313333</externalid>
        <name>OAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313307</externalid>
        <name>GLS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347754</externalid>
        <name>CCBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q816</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925788</externalid>
        <name>2-oxoglutaramate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31143</externalid>
        <name>N-acetyl-L-aspartate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16953</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114898</externalid>
        <name>(S)-1-pyrroline-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693766</externalid>
        <name>Ac-Asp-Glu(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760847</externalid>
        <name>L-glutamic 5-semialdehyde zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964539</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964540</externalid>
    <name>Alanine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964540</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346392</externalid>
        <name>GPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313178</externalid>
        <name>GPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964540</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70895</externalid>
    <name>Branched-chain amino acid catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70895</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313423</externalid>
        <name>AUH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313493</externalid>
        <name>ALDH6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313380</externalid>
        <name>BCAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387153</externalid>
        <name>BCKDK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313390</externalid>
        <name>BCAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387129</externalid>
        <name>BCKDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313468</externalid>
        <name>ECHS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387133</externalid>
        <name>BCKDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21839</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313409</externalid>
        <name>MCCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313432</externalid>
        <name>ACADSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313400</externalid>
        <name>IVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313477</externalid>
        <name>HIBCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387139</externalid>
        <name>DBT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313484</externalid>
        <name>HIBADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313459</externalid>
        <name>ACAD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0NXR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387162</externalid>
        <name>PPM1K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2PC20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313413</externalid>
        <name>MCCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313450</externalid>
        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313441</externalid>
        <name>HSD17B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02691</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9917132</externalid>
        <name>2-methylcrotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57337</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316161</externalid>
        <name>3-methyl-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917130</externalid>
        <name>trans-3-methylglutaconyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859161</externalid>
        <name>(R)-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>156439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317429</externalid>
        <name>(S)-3-hydroxyisobutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317402</externalid>
        <name>(S)-3-methyl-2-oxovalerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760744</externalid>
        <name>isovaleryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29794</externalid>
        <name>4-methyl-2-oxopentanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760749</externalid>
        <name>3-methylbut-2-enoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917117</externalid>
        <name>methacrylyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917114</externalid>
        <name>(S)-3-hydroxyisobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62611</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917121</externalid>
        <name>2-methylacetoacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9917133</externalid>
        <name>(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57312</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164166</externalid>
        <name>(S)-methylmalonate semialdehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62413</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859158</externalid>
        <name>isobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735743</externalid>
        <name>(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914039</externalid>
        <name>propionyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9859138</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-70895</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9859138</externalid>
    <name>BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9859138</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387139</externalid>
        <name>DBT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387129</externalid>
        <name>BCKDHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387133</externalid>
        <name>BCKDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21839</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316161</externalid>
        <name>3-methyl-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11851</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859161</externalid>
        <name>(R)-2-methylbutanoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>156439</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317402</externalid>
        <name>(S)-3-methyl-2-oxovalerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35146</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760744</externalid>
        <name>isovaleryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29794</externalid>
        <name>4-methyl-2-oxopentanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9859158</externalid>
        <name>isobutyryl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57338</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9859138</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-70895</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70921</externalid>
    <name>Histidine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70921</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313516</externalid>
        <name>AMDHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402927</externalid>
        <name>CARNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313523</externalid>
        <name>FTCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313500</externalid>
        <name>HAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351073</externalid>
        <name>HDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389665</externalid>
        <name>CARNS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313507</externalid>
        <name>UROC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925932</externalid>
        <name>5-formimidoyltetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760756</externalid>
        <name>carnosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925933</externalid>
        <name>N-formimidoyl-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58928</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760898</externalid>
        <name>anserine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925938</externalid>
        <name>trans-urocanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17771</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925950</externalid>
        <name>3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77893</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70921</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71064</externalid>
    <name>Lysine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71064</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334847</externalid>
        <name>SLC25A21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313716</externalid>
        <name>GCDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418120</externalid>
        <name>DHTKD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389076</externalid>
        <name>PIPOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389869</externalid>
        <name>HYKK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313544</externalid>
        <name>ALDH7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388025</externalid>
        <name>PHYKPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387182</externalid>
        <name>CRYM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313532</externalid>
        <name>AASS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E657</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313553</externalid>
        <name>AADAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925998</externalid>
        <name>erythro-5-phosphonatoooxy-L-lysinium(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760912</externalid>
        <name>L-allysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58321</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925986</externalid>
        <name>1-piperideine-2-carboxylic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925990</externalid>
        <name>erythro-5-hydroxy-L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58357</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760740</externalid>
        <name>crotonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317106</externalid>
        <name>L-pipecolic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61185</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760761</externalid>
        <name>glutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925991</externalid>
        <name>L-saccharopinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57951</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9858329</externalid>
        <name>2-oxoadipate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760863</externalid>
        <name>L-2-aminoadipate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58672</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316849</externalid>
        <name>(S)-1-piperideine-6-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58769</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9858328</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-71064</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9858328</externalid>
    <name>OADH complex synthesizes glutaryl-CoA from 2-OA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9858328</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10418120</externalid>
        <name>DHTKD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9858329</externalid>
        <name>2-oxoadipate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760761</externalid>
        <name>glutaryl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9858328</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71064</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963691</externalid>
    <name>Phenylalanine and tyrosine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963691</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313757</externalid>
        <name>PCBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313790</externalid>
        <name>HGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B8YB76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388014</externalid>
        <name>ASRGL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313766</externalid>
        <name>TAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313748</externalid>
        <name>QDPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313808</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313776</externalid>
        <name>HPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347754</externalid>
        <name>CCBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q816</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313739</externalid>
        <name>PAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365559</externalid>
        <name>IL4I1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573400</externalid>
        <name>4-fumarylacetoacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929219</externalid>
        <name>(6R)-L-erythro-6,7-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>584170</externalid>
        <name>homogentisate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423724</externalid>
        <name>keto-phenylpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18005</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114869</externalid>
        <name>4-maleylacetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8964208</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963684</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8963691</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964208</externalid>
    <name>Phenylalanine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964208</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313757</externalid>
        <name>PCBD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388014</externalid>
        <name>ASRGL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313748</externalid>
        <name>QDPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347754</externalid>
        <name>CCBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q816</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313739</externalid>
        <name>PAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365559</externalid>
        <name>IL4I1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423724</externalid>
        <name>keto-phenylpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18005</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929219</externalid>
        <name>(6R)-L-erythro-6,7-dihydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964208</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963691</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963684</externalid>
    <name>Tyrosine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963684</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313790</externalid>
        <name>HGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B8YB76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313766</externalid>
        <name>TAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313808</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313776</externalid>
        <name>HPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114869</externalid>
        <name>4-maleylacetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573400</externalid>
        <name>4-fumarylacetoacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316781</externalid>
        <name>3-(4-hydroxyphenyl)pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>584170</externalid>
        <name>homogentisate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963684</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963691</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70688</externalid>
    <name>Proline catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70688</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313354</externalid>
        <name>PRODH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3Y2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389127</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313361</externalid>
        <name>ALDH4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38065</externalid>
        <name>erythro-4-hydroxy-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760847</externalid>
        <name>L-glutamic 5-semialdehyde zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317514</externalid>
        <name>(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114898</externalid>
        <name>(S)-1-pyrroline-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70688</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-977347</externalid>
    <name>Serine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-977347</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10403480</externalid>
        <name>SERINC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409300</externalid>
        <name>SDSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351099</externalid>
        <name>PSAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403484</externalid>
        <name>SERINC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403472</externalid>
        <name>SERINC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351109</externalid>
        <name>PHGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T866</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351090</externalid>
        <name>PSPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409319</externalid>
        <name>SRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409293</externalid>
        <name>SDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403488</externalid>
        <name>SERINC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403476</externalid>
        <name>SERINC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9674781</externalid>
        <name>3-phosphonato-D-glycerate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58272</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929454</externalid>
        <name>O-phosphonato-L-serine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316215</externalid>
        <name>3-phosphonatooxypyruvate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-977347</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8849175</externalid>
    <name>Threonine catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8849175</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409300</externalid>
        <name>SDSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409293</externalid>
        <name>SDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409312</externalid>
        <name>RIDA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T114</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929618</externalid>
        <name>2-iminobutanoic acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8849175</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71240</externalid>
    <name>Tryptophan catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71240</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313833</externalid>
        <name>KYNU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313817</externalid>
        <name>TDO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334687</externalid>
        <name>SLC7A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NNN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313843</externalid>
        <name>HAAO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328807</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LFW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347742</externalid>
        <name>IDO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401789</externalid>
        <name>SLC36A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313826</externalid>
        <name>KMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M294</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347754</externalid>
        <name>CCBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q816</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334674</externalid>
        <name>SLC3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313553</externalid>
        <name>AADAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939575</externalid>
        <name>(R)-indole-3-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55528</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929690</externalid>
        <name>cis,cis-2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929650</externalid>
        <name>3-hydroxyanthranilate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36559</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929651</externalid>
        <name>L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929683</externalid>
        <name>4-(2-aminophenyl)-2,4-dioxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58147</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8939574</externalid>
        <name>3-(1H-indol-3-yl)propanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929647</externalid>
        <name>3-hydroxy-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929635</externalid>
        <name>N-formyl-L-kynurenine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-71240</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1614635</externalid>
    <name>Sulfur amino acid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1614635</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10354333</externalid>
        <name>ENOPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358831</externalid>
        <name>SQOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325257</externalid>
        <name>MAT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358795</externalid>
        <name>CBS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358852</externalid>
        <name>CDO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K1V1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408887</externalid>
        <name>MPST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334900</externalid>
        <name>SLC25A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358861</externalid>
        <name>BHMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333757</externalid>
        <name>FMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N427</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354324</externalid>
        <name>ADI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388258</externalid>
        <name>BHMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389785</externalid>
        <name>GADL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358805</externalid>
        <name>SUOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397562</externalid>
        <name>ADO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325284</externalid>
        <name>AHCY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325223</externalid>
        <name>MTRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409156</externalid>
        <name>TST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354342</externalid>
        <name>MTAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358838</externalid>
        <name>ETHE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T094</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358816</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359176</externalid>
        <name>TSTD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354317</externalid>
        <name>MRI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371927</externalid>
        <name>TXN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9762308</externalid>
        <name>N,N-dimethylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930123</externalid>
        <name>disulfanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937158</externalid>
        <name>sulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760787</externalid>
        <name>trioxidosulfanidosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237170</externalid>
        <name>S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929696</externalid>
        <name>L-cystathionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58161</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237127</externalid>
        <name>4-methylthio-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237131</externalid>
        <name>5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929929</externalid>
        <name>L-lanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48605</externalid>
        <name>hydrogensulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316197</externalid>
        <name>1,2-dihydroxy-5-(methylthio)pent-1-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237088</externalid>
        <name>S-methyl-5-thio-D-ribulose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929693</externalid>
        <name>S-methyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760851</externalid>
        <name>hypotaurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929922</externalid>
        <name>L-homolanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930117</externalid>
        <name>3-mercaptopyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57678</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760812</externalid>
        <name>3-sulfino-L-alanine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930121</externalid>
        <name>S-sulfanylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1237112</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614603</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614558</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1614635</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1237112</externalid>
    <name>Methionine salvage pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1237112</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10354333</externalid>
        <name>ENOPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354342</externalid>
        <name>MTAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354317</externalid>
        <name>MRI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354324</externalid>
        <name>ADI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237170</externalid>
        <name>S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316197</externalid>
        <name>1,2-dihydroxy-5-(methylthio)pent-1-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237088</externalid>
        <name>S-methyl-5-thio-D-ribulose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237127</externalid>
        <name>4-methylthio-2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16723</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1237131</externalid>
        <name>5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1237112</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614635</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1614603</externalid>
    <name>Cysteine formation from homocysteine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1614603</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358795</externalid>
        <name>CBS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358816</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929696</externalid>
        <name>L-cystathionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58161</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1614603</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614635</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1614558</externalid>
    <name>Degradation of cysteine and homocysteine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1614558</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358831</externalid>
        <name>SQOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358852</externalid>
        <name>CDO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K1V1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408887</externalid>
        <name>MPST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334900</externalid>
        <name>SLC25A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333757</externalid>
        <name>FMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N427</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389785</externalid>
        <name>GADL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358805</externalid>
        <name>SUOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397562</externalid>
        <name>ADO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409156</externalid>
        <name>TST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358838</externalid>
        <name>ETHE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T094</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358816</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359176</externalid>
        <name>TSTD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371927</externalid>
        <name>TXN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31613</externalid>
        <name>hydrogen cyanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930123</externalid>
        <name>disulfanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316917</externalid>
        <name>2-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937158</externalid>
        <name>sulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48605</externalid>
        <name>hydrogensulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17137</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760851</externalid>
        <name>hypotaurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760787</externalid>
        <name>trioxidosulfanidosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929922</externalid>
        <name>L-homolanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178194</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930117</externalid>
        <name>3-mercaptopyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57678</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9837408</externalid>
        <name>cysteaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58029</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760812</externalid>
        <name>3-sulfino-L-alanine(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930121</externalid>
        <name>S-sulfanylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929929</externalid>
        <name>L-lanthionine dizwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>178193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1614517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1614558</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614635</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1614517</externalid>
    <name>Sulfide oxidation to sulfate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1614517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358831</externalid>
        <name>SQOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358805</externalid>
        <name>SUOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358838</externalid>
        <name>ETHE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T094</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334900</externalid>
        <name>SLC25A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359176</externalid>
        <name>TSTD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1614661</externalid>
        <name>molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760787</externalid>
        <name>trioxidosulfanidosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33542</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930121</externalid>
        <name>S-sulfanylglutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>937158</externalid>
        <name>sulfite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1614517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1614558</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2408522</externalid>
    <name>Selenoamino acid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2408522</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>103882</externalid>
        <name>TXNRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325257</externalid>
        <name>MAT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367751</externalid>
        <name>SCLY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9930580</externalid>
        <name>selanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29317</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930578</externalid>
        <name>L-adenosylselenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357682</externalid>
        <name>methylselenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64685</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357668</externalid>
        <name>methylseleninic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357689</externalid>
        <name>methylselenenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930571</externalid>
        <name>L-selenocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930579</externalid>
        <name>L-selenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2408508</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5263617</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2408522</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2408508</externalid>
    <name>Metabolism of ingested SeMet, Sec, MeSec into H2Se</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2408508</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325257</externalid>
        <name>MAT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367751</externalid>
        <name>SCLY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9930580</externalid>
        <name>selanide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29317</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930578</externalid>
        <name>L-adenosylselenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930571</externalid>
        <name>L-selenocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57843</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930579</externalid>
        <name>L-selenomethionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2408508</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2408522</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5263617</externalid>
    <name>Metabolism of ingested MeSeO2H into MeSeH</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5263617</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>103882</externalid>
        <name>TXNRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5357668</externalid>
        <name>methylseleninic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357689</externalid>
        <name>methylselenenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5357682</externalid>
        <name>methylselenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64685</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5263617</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2408522</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-389661</externalid>
    <name>Glyoxylate metabolism and glycine degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-389661</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387385</externalid>
        <name>GCSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20821</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347787</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391026</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389127</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387409</externalid>
        <name>AMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313271</externalid>
        <name>GOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12344</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391030</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M678</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387395</externalid>
        <name>GLDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339214</externalid>
        <name>HAO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339207</externalid>
        <name>GRHPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NGN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396901</externalid>
        <name>DDO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389157</externalid>
        <name>HOGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339196</externalid>
        <name>DAO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339129</externalid>
        <name>AGXT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313361</externalid>
        <name>ALDH4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153365</externalid>
        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82908</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9930611</externalid>
        <name>1,4-benzoquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132124</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930607</externalid>
        <name>hydroquinones</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24646</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693964</externalid>
        <name>N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762309</externalid>
        <name>sarcosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38065</externalid>
        <name>erythro-4-hydroxy-L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784232</externalid>
        <name>4-hydroxy-2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17742</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317514</externalid>
        <name>(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861965</externalid>
        <name>glyoxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36655</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316562</externalid>
        <name>glycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693979</externalid>
        <name>N(6)-dihydrolipoyl-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316154</externalid>
        <name>oxaloacetate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16452</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6783984</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-389661</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6783984</externalid>
    <name>Glycine degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6783984</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387385</externalid>
        <name>GCSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20821</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387409</externalid>
        <name>AMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313971</externalid>
        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387395</externalid>
        <name>GLDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313963</externalid>
        <name>DLST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153365</externalid>
        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82908</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316165</externalid>
        <name>(6S)-5,6,7,8-tetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693964</externalid>
        <name>N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14949</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35831</externalid>
        <name>(6R)-5,10-methylenetetrahydrofolate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693979</externalid>
        <name>N(6)-dihydrolipoyl-L-lysine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50746</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6783984</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389661</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-70635</externalid>
    <name>Urea cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-70635</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313215</externalid>
        <name>ARG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313239</externalid>
        <name>NMRAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345534</externalid>
        <name>ARG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313233</externalid>
        <name>ASS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14568</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313224</externalid>
        <name>ASL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313199</externalid>
        <name>CPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313320</externalid>
        <name>SLC25A15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313206</externalid>
        <name>OTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313324</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313190</externalid>
        <name>NAGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385406</externalid>
        <name>SIRT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736387</externalid>
        <name>carbamoyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760754</externalid>
        <name>(N(omega)-L-arginino)succinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57472</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955516</externalid>
        <name>2''-O-glutaryl-ADP-D-ribose(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87829</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316155</externalid>
        <name>fumarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114852</externalid>
        <name>N-acetyl-L-glutamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-70635</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71262</externalid>
    <name>Carnitine synthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71262</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10313852</externalid>
        <name>TMLHE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313873</externalid>
        <name>ALDH9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313863</externalid>
        <name>SHMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313882</externalid>
        <name>BBOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4U6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9794619</externalid>
        <name>(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>141499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114872</externalid>
        <name>4-trimethylammoniobutanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114875</externalid>
        <name>4-(trimethylammonio)butanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16244</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9794601</externalid>
        <name>N(6),N(6),N(6)-trimethyl-L-lysine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58100</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-71262</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71288</externalid>
    <name>Creatine metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71288</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10329991</externalid>
        <name>SLC6A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313893</externalid>
        <name>GATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313902</externalid>
        <name>GAMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329968</externalid>
        <name>CKMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TTK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329962</externalid>
        <name>CKMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329979</externalid>
        <name>SLC6A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18875</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329943</externalid>
        <name>CKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329983</externalid>
        <name>SLC6A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329949</externalid>
        <name>CKM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760852</externalid>
        <name>creatine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114851</externalid>
        <name>guanidinoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760845</externalid>
        <name>N-phosphocreatinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58092</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-71288</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6798163</externalid>
    <name>Choline catabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6798163</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343749</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313544</externalid>
        <name>ALDH7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358861</externalid>
        <name>BHMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390931</externalid>
        <name>SARDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390892</externalid>
        <name>DMGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390948</externalid>
        <name>CHDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BES2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9762308</externalid>
        <name>N,N-dimethylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58251</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30391</externalid>
        <name>betaine aldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15710</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762309</externalid>
        <name>sarcosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6798163</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-351202</externalid>
    <name>Metabolism of polyamines</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-351202</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334382</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334413</externalid>
        <name>AGMAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N858</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334391</externalid>
        <name>AZIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334467</externalid>
        <name>SMS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313370</externalid>
        <name>ODC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27117</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321135</externalid>
        <name>SMOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334406</externalid>
        <name>AZIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334398</externalid>
        <name>NQO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334374</externalid>
        <name>OAZ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334481</externalid>
        <name>AMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50243</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334474</externalid>
        <name>SRM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321142</externalid>
        <name>PAOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334378</externalid>
        <name>OAZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N021</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334458</externalid>
        <name>SAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760753</externalid>
        <name>S-adenosylmethioninaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57443</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-351143</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351200</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-350562</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-351202</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-351143</externalid>
    <name>Agmatine biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-351143</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334413</externalid>
        <name>AGMAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N858</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334406</externalid>
        <name>AZIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-351143</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-351200</externalid>
    <name>Interconversion of polyamines</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-351200</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321142</externalid>
        <name>PAOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321135</externalid>
        <name>SMOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334458</externalid>
        <name>SAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-351200</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-350562</externalid>
    <name>Regulation of ornithine decarboxylase (ODC)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-350562</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334382</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334391</externalid>
        <name>AZIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313370</externalid>
        <name>ODC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27117</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334398</externalid>
        <name>NQO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334374</externalid>
        <name>OAZ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334378</externalid>
        <name>OAZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N021</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-350562</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-351202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5662702</externalid>
    <name>Melanin biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5662702</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10382487</externalid>
        <name>TYR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382494</externalid>
        <name>OCA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382498</externalid>
        <name>SLC45A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382478</externalid>
        <name>DCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403241</externalid>
        <name>TYRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762301</externalid>
        <name>5,6-dihydroxyindole-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37509</externalid>
        <name>5,6-dihydroxyindole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942549</externalid>
        <name>indole-5,6-quinone-2-carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>177869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942552</externalid>
        <name>L-dopaquinone zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57924</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942548</externalid>
        <name>L-dopachromate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57509</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5662702</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209776</externalid>
    <name>Metabolism of amine-derived hormones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209776</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332605</externalid>
        <name>DIO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332679</externalid>
        <name>TPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332625</externalid>
        <name>DUOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332614</externalid>
        <name>AANAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334447</externalid>
        <name>DIO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332743</externalid>
        <name>SLC5A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332645</externalid>
        <name>DUOXA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332637</externalid>
        <name>TPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332670</externalid>
        <name>TH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332621</externalid>
        <name>DUOXA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H723</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332750</externalid>
        <name>IYD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332649</externalid>
        <name>DUOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332736</externalid>
        <name>PNMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N083</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332683</externalid>
        <name>TPH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332633</externalid>
        <name>TXNDC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332727</externalid>
        <name>DBH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332710</externalid>
        <name>DDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332663</externalid>
        <name>ASMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10950</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33327</externalid>
        <name>3-iodo-L-tyrosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760906</externalid>
        <name>5-hydroxy-L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31683</externalid>
        <name>diiodine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762228</externalid>
        <name>3,5-diiodo-L-tyrosinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57506</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31045</externalid>
        <name>N-acetylserotonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29568</externalid>
        <name>pyrroloquinoline quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622408</externalid>
        <name>hydrogen iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-209905</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209968</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209931</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-209776</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71291</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209905</externalid>
    <name>Catecholamine biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209905</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332670</externalid>
        <name>TH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332736</externalid>
        <name>PNMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N083</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332727</externalid>
        <name>DBH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332710</externalid>
        <name>DDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162975</externalid>
        <name>L-dehydroascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58539</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29568</externalid>
        <name>pyrroloquinoline quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-209905</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209776</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209968</externalid>
    <name>Thyroxine biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209968</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332605</externalid>
        <name>DIO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332625</externalid>
        <name>DUOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334447</externalid>
        <name>DIO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332743</externalid>
        <name>SLC5A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332645</externalid>
        <name>DUOXA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332637</externalid>
        <name>TPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332621</externalid>
        <name>DUOXA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H723</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332750</externalid>
        <name>IYD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332649</externalid>
        <name>DUOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332633</externalid>
        <name>TXNDC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>33327</externalid>
        <name>3-iodo-L-tyrosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31683</externalid>
        <name>diiodine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17606</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762228</externalid>
        <name>3,5-diiodo-L-tyrosinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57506</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622408</externalid>
        <name>hydrogen iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43451</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-350864</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-209968</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209776</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-350864</externalid>
    <name>Regulation of thyroid hormone activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-350864</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332605</externalid>
        <name>DIO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334447</externalid>
        <name>DIO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I3B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-350864</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209968</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209931</externalid>
    <name>Serotonin and melatonin biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209931</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332679</externalid>
        <name>TPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332683</externalid>
        <name>TPH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332614</externalid>
        <name>AANAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332710</externalid>
        <name>DDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332663</externalid>
        <name>ASMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10950</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38867</externalid>
        <name>4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15642</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760906</externalid>
        <name>5-hydroxy-L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31045</externalid>
        <name>N-acetylserotonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17697</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-209931</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209776</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-189445</externalid>
    <name>Metabolism of porphyrins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-189445</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326962</externalid>
        <name>HMOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327047</externalid>
        <name>UROS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QDV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327019</externalid>
        <name>ALAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326980</externalid>
        <name>CPOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348863</externalid>
        <name>FLVCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340188</externalid>
        <name>FABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326941</externalid>
        <name>BLVRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52556</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356212</externalid>
        <name>ABCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326956</externalid>
        <name>HMOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369871</externalid>
        <name>COX10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327026</externalid>
        <name>ALAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326945</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325571</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327038</externalid>
        <name>FECH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22600</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325583</externalid>
        <name>GSTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326998</externalid>
        <name>UROD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326971</externalid>
        <name>HMBS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369878</externalid>
        <name>COX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327007</externalid>
        <name>ALAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326989</externalid>
        <name>PPOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56602</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640392</externalid>
        <name>porphobilinogen(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640384</externalid>
        <name>5-ammoniolevulinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>356416</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853722</externalid>
        <name>protoporphyrin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760911</externalid>
        <name>coproporphyrinogen I(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853737</externalid>
        <name>protoporphyrinogen(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39273</externalid>
        <name>lead(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27889</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854162</externalid>
        <name>ferroheme o(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853736</externalid>
        <name>uroporphyrinogen III(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57308</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189459</externalid>
        <name>dipyrromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853726</externalid>
        <name>coproporphyrinogen III(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57309</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760923</externalid>
        <name>bis(beta-glucosyluronate)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760920</externalid>
        <name>uroporphyrinogen I(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34543</externalid>
        <name>mono(glucosyluronic acid)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640393</externalid>
        <name>preuroporphyrinogen(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-189451</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-189483</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-189445</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-189451</externalid>
    <name>Heme biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-189451</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10369871</externalid>
        <name>COX10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327047</externalid>
        <name>UROS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QDV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327026</externalid>
        <name>ALAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327038</externalid>
        <name>FECH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22600</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327019</externalid>
        <name>ALAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326980</externalid>
        <name>CPOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326998</externalid>
        <name>UROD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326971</externalid>
        <name>HMBS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348863</externalid>
        <name>FLVCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369878</externalid>
        <name>COX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327007</externalid>
        <name>ALAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326989</externalid>
        <name>PPOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56602</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640385</externalid>
        <name>succinyl-CoA(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57292</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640392</externalid>
        <name>porphobilinogen(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58126</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640384</externalid>
        <name>5-ammoniolevulinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>356416</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853722</externalid>
        <name>protoporphyrin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760911</externalid>
        <name>coproporphyrinogen I(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853737</externalid>
        <name>protoporphyrinogen(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39273</externalid>
        <name>lead(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27889</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854162</externalid>
        <name>ferroheme o(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60530</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853736</externalid>
        <name>uroporphyrinogen III(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57308</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>189459</externalid>
        <name>dipyrromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853726</externalid>
        <name>coproporphyrinogen III(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57309</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760920</externalid>
        <name>uroporphyrinogen I(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9640393</externalid>
        <name>preuroporphyrinogen(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-189451</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-189445</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-189483</externalid>
    <name>Heme degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-189483</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326962</externalid>
        <name>HMOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326956</externalid>
        <name>HMOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356212</externalid>
        <name>ABCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326945</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325571</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325583</externalid>
        <name>GSTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340188</externalid>
        <name>FABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326941</externalid>
        <name>BLVRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52556</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760923</externalid>
        <name>bis(beta-glucosyluronate)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58471</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34543</externalid>
        <name>mono(glucosyluronic acid)bilirubin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-189483</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-189445</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211859</externalid>
    <name>Biological oxidations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211859</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10393798</externalid>
        <name>TRMT112</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325615</externalid>
        <name>GSTM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354419</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407009</externalid>
        <name>PODXL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325214</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407021</externalid>
        <name>TPST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400684</externalid>
        <name>UXS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333766</externalid>
        <name>FMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403761</externalid>
        <name>CBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325597</externalid>
        <name>GSTM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387950</externalid>
        <name>AS3MT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N140</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378928</externalid>
        <name>ACY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325684</externalid>
        <name>MGST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403644</externalid>
        <name>NQO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332703</externalid>
        <name>CYP2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317887</externalid>
        <name>PTGIS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320691</externalid>
        <name>PTGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322111</externalid>
        <name>ACSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP7</externalid>
            </xref>
          </protein>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490350</externalid>
        <name>Aflatoxin B1 exo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48225</externalid>
        <name>8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692441</externalid>
        <name>Carboxyphosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327961</externalid>
        <name>4-hydroxy-17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114887</externalid>
        <name>purine-6-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693660</externalid>
        <name>ecgonine benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395215</externalid>
        <name>7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176504</externalid>
        <name>2-acetamidofluorene N-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694070</externalid>
        <name>Benzo[a]pyrene-4,5-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40933</externalid>
        <name>N'-acetylisoniazid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7207</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5643846</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40555</externalid>
        <name>paclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45863</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176578</externalid>
        <name>3,3'-diiodothyronine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31615</externalid>
        <name>hydrogen chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327985</externalid>
        <name>4-hydroxyphenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696232</externalid>
        <name>dimethylarsinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327675</externalid>
        <name>3-hydroxy-4-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40653</externalid>
        <name>phenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395386</externalid>
        <name>tamoxifen N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176561</externalid>
        <name>4-nitrophenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162114</externalid>
        <name>acetyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40574</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30227</externalid>
        <name>tyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395393</externalid>
        <name>4-acetamidosalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395863</externalid>
        <name>debrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34665</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31725</externalid>
        <name>cocaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327680</externalid>
        <name>12-HETE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786182</externalid>
        <name>Olmesartan medoxomil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760983</externalid>
        <name>cholesterol sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40425</externalid>
        <name>omeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7772</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176612</externalid>
        <name>3,3',5-triiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6800152</externalid>
        <name>dimethylarsinic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48765</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395385</externalid>
        <name>sulfacetamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694576</externalid>
        <name>mycophenolic acid O-acyl-glucuronide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30311</externalid>
        <name>hydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316406</externalid>
        <name>arsenite(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490359</externalid>
        <name>Aflatoxin B1 endo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760978</externalid>
        <name>S-(2,4-dinitrophenyl)glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>183157</externalid>
        <name>5-acetamido-6-formamido-3-methyluracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166608</externalid>
        <name>S-(2-hydroxyethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166605</externalid>
        <name>dopamine 3-O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114908</externalid>
        <name>sulfanilamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176506</externalid>
        <name>pregnenolone sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692439</externalid>
        <name>4-hydroperoxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>196991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796683</externalid>
        <name>L-cysteinylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943294</externalid>
        <name>doxorubicinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490346</externalid>
        <name>Aflatoxin B1 endo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34835</externalid>
        <name>resveratrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114930</externalid>
        <name>umbelliferone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27510</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216637</externalid>
        <name>3-hydroxypalmitic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176589</externalid>
        <name>3,3'-diiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786178</externalid>
        <name>diketone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29848</externalid>
        <name>benzaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490353</externalid>
        <name>aflatoxin M1 8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327986</externalid>
        <name>4-hydroxytolbutamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31239</externalid>
        <name>trimethylamine N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327677</externalid>
        <name>(24S)-1alpha,24,25-trihydroxyvitamin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490358</externalid>
        <name>Aflatoxin B1 exo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784965</externalid>
        <name>valacyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327669</externalid>
        <name>19-hydroxyprostaglandin H2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114913</externalid>
        <name>12-hydroxylauric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>39567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30193</externalid>
        <name>1H-indole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395394</externalid>
        <name>desmethyl loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166420</externalid>
        <name>N-acetoxy-1,1'-biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317372</externalid>
        <name>quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36141</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327678</externalid>
        <name>3-methyleneindolenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395397</externalid>
        <name>4-acetamidobenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114846</externalid>
        <name>trimethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696217</externalid>
        <name>methylarsonite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33435</externalid>
        <name>taurolithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33603</externalid>
        <name>N-methylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6793344</externalid>
        <name>benzo[a]pyrene-7,8-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87752</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692223</externalid>
        <name>benzo[a]pyrene-cis-7,8-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30875</externalid>
        <name>4-nitrophenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760977</externalid>
        <name>lithocholate sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327966</externalid>
        <name>4-hydroxydebrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63800</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316350</externalid>
        <name>S-(hydroxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490356</externalid>
        <name>aflatoxin Q1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490351</externalid>
        <name>aflatoxin B1 endo-8,9-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78586</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114902</externalid>
        <name>ethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40945</externalid>
        <name>phenacetin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327681</externalid>
        <name>3,16-dihydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5688992</externalid>
        <name>4-ethoxyaniline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490357</externalid>
        <name>Aflatoxin B1 exo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5618013</externalid>
        <name>aflatoxin B1 triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29788</externalid>
        <name>3,4-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915885</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176607</externalid>
        <name>26-hydroxycholesterol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490352</externalid>
        <name>Aflatoxin B1 exo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30379</externalid>
        <name>4-aminobenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936450</externalid>
        <name>Mo-molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760413</externalid>
        <name>mycophenolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694131</externalid>
        <name>Benzo[a]pyrene-cis-4,5-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216566</externalid>
        <name>indolin-2-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39963</externalid>
        <name>loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6532</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490349</externalid>
        <name>Aflatoxin B1 endo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327978</externalid>
        <name>5'-hydroxyomeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63840</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35105</externalid>
        <name>(4-hydroxyphenyl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395390</externalid>
        <name>methimazole S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39913</externalid>
        <name>isoniazide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6030</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936428</externalid>
        <name>N(omega)-hydroxyarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490343</externalid>
        <name>aflatoxin B1 dialdehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176590</externalid>
        <name>N-hydroxy-2-acetamidofluorene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490347</externalid>
        <name>Aflatoxin B1 endo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78578</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327974</externalid>
        <name>4-hydroxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42365</externalid>
        <name>skatole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9171</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760789</externalid>
        <name>methylarsonate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166419</externalid>
        <name>N-hydroxy-4-aminobiphenyl O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32701</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395217</externalid>
        <name>6-hydroxypaclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63859</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166417</externalid>
        <name>benzo[a]pyrene diol epoxide I</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166587</externalid>
        <name>phenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114859</externalid>
        <name>pyridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695956</externalid>
        <name>p-nitrophenyl butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85867</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163084</externalid>
        <name>1-chloro-2,4-dinitrobenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34718</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796682</externalid>
        <name>5-oxo-L-prolinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936512</externalid>
        <name>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33333</externalid>
        <name>4-aminosalicylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40379</externalid>
        <name>methylarsonous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17826</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760976</externalid>
        <name>benzylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>225238</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760924</externalid>
        <name>L-gamma-glutamyl-L-cysteinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39679</externalid>
        <name>cyclophosphamide hydrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42447</externalid>
        <name>17beta-estradiol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36961</externalid>
        <name>imidazole-4-acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490348</externalid>
        <name>aflatoxin M1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78576</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5423646</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-211859</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211945</externalid>
    <name>Phase I - Functionalization of compounds</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211945</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333766</externalid>
        <name>FMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403761</externalid>
        <name>CBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403644</externalid>
        <name>NQO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332703</externalid>
        <name>CYP2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317887</externalid>
        <name>PTGIS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320691</externalid>
        <name>PTGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327729</externalid>
        <name>CYP39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H722</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317747</externalid>
        <name>CYP2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYW0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10314212</externalid>
        <name>ADH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385706</externalid>
        <name>AADAC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389641</externalid>
        <name>CMBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2I5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328947</externalid>
        <name>CYB5R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333172</externalid>
        <name>CYP26C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDT5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333248</externalid>
        <name>CYP26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZS4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314224</externalid>
        <name>ADH7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314218</externalid>
        <name>ADH6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZN9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333158</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327861</externalid>
        <name>CYP19A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327705</externalid>
        <name>CYP46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333252</externalid>
        <name>CYP26B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387320</externalid>
        <name>CES2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317875</externalid>
        <name>AHRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317867</externalid>
        <name>ARNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386985</externalid>
        <name>ALDH3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N015</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344888</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317721</externalid>
        <name>CYP2B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU42</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321124</externalid>
        <name>MAOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389232</externalid>
        <name>BPHL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386967</externalid>
        <name>ADH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317782</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387893</externalid>
        <name>ALDH1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342248</externalid>
        <name>CYB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403604</externalid>
        <name>MTARC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387925</externalid>
        <name>AOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317857</externalid>
        <name>AHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321135</externalid>
        <name>SMOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317894</externalid>
        <name>TBXAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387314</externalid>
        <name>CES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403768</externalid>
        <name>CES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332720</externalid>
        <name>CYP27B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403610</externalid>
        <name>MTARC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320674</externalid>
        <name>FMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332598</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321142</externalid>
        <name>PAOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328420</externalid>
        <name>CYP51A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387428</externalid>
        <name>EPHX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317786</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333203</externalid>
        <name>CYP2U1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387932</externalid>
        <name>AOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TTK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389658</externalid>
        <name>CYP4V2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333757</externalid>
        <name>FMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N427</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314253</externalid>
        <name>ACSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314235</externalid>
        <name>ALDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20000</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327834</externalid>
        <name>CYP11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385702</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317743</externalid>
        <name>CYP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387916</externalid>
        <name>ABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5317372</externalid>
        <name>quinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36141</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327678</externalid>
        <name>3-methyleneindolenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114846</externalid>
        <name>trimethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692441</externalid>
        <name>Carboxyphosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327961</externalid>
        <name>4-hydroxy-17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693660</externalid>
        <name>ecgonine benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41001</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694070</externalid>
        <name>Benzo[a]pyrene-4,5-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5643846</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40555</externalid>
        <name>paclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45863</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327966</externalid>
        <name>4-hydroxydebrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63800</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327985</externalid>
        <name>4-hydroxyphenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316350</externalid>
        <name>S-(hydroxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40653</externalid>
        <name>phenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395386</externalid>
        <name>tamoxifen N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162114</externalid>
        <name>acetyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40574</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30227</externalid>
        <name>tyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114902</externalid>
        <name>ethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40945</externalid>
        <name>phenacetin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395863</externalid>
        <name>debrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34665</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327681</externalid>
        <name>3,16-dihydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5688992</externalid>
        <name>4-ethoxyaniline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31725</externalid>
        <name>cocaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27958</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915885</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327680</externalid>
        <name>12-HETE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786182</externalid>
        <name>Olmesartan medoxomil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936450</externalid>
        <name>Mo-molybdopterin cofactor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21437</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40425</externalid>
        <name>omeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7772</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694131</externalid>
        <name>Benzo[a]pyrene-cis-4,5-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216566</externalid>
        <name>indolin-2-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39963</externalid>
        <name>loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6532</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327978</externalid>
        <name>5'-hydroxyomeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63840</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35105</externalid>
        <name>(4-hydroxyphenyl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30311</externalid>
        <name>hydroquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17594</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395390</externalid>
        <name>methimazole S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936428</externalid>
        <name>N(omega)-hydroxyarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327974</externalid>
        <name>4-hydroxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42365</externalid>
        <name>skatole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9171</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692439</externalid>
        <name>4-hydroperoxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>196991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34243</externalid>
        <name>N-ribosylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15927</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943294</externalid>
        <name>doxorubicinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395217</externalid>
        <name>6-hydroxypaclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63859</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34835</externalid>
        <name>resveratrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114930</externalid>
        <name>umbelliferone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27510</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216637</externalid>
        <name>3-hydroxypalmitic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786178</externalid>
        <name>diketone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29848</externalid>
        <name>benzaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17169</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8936512</externalid>
        <name>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55458</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327986</externalid>
        <name>4-hydroxytolbutamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31239</externalid>
        <name>trimethylamine N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327677</externalid>
        <name>(24S)-1alpha,24,25-trihydroxyvitamin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784965</externalid>
        <name>valacyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760976</externalid>
        <name>benzylaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>225238</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327669</externalid>
        <name>19-hydroxyprostaglandin H2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114913</externalid>
        <name>12-hydroxylauric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>39567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39679</externalid>
        <name>cyclophosphamide hydrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30193</externalid>
        <name>1H-indole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395394</externalid>
        <name>desmethyl loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36961</externalid>
        <name>imidazole-4-acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27398</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-217271</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140180</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140179</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-71384</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8937144</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-211945</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211859</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211897</externalid>
    <name>Cytochrome P450 - arranged by substrate type</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211897</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317782</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317857</externalid>
        <name>AHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332703</externalid>
        <name>CYP2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317887</externalid>
        <name>PTGIS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317894</externalid>
        <name>TBXAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327729</externalid>
        <name>CYP39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317747</externalid>
        <name>CYP2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332720</externalid>
        <name>CYP27B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332598</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333172</externalid>
        <name>CYP26C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328420</externalid>
        <name>CYP51A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333248</externalid>
        <name>CYP26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333158</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327861</externalid>
        <name>CYP19A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317786</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327705</externalid>
        <name>CYP46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333203</externalid>
        <name>CYP2U1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389658</externalid>
        <name>CYP4V2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333252</externalid>
        <name>CYP26B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327834</externalid>
        <name>CYP11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317867</externalid>
        <name>ARNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317875</externalid>
        <name>AHRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333193</externalid>
        <name>CYP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317743</externalid>
        <name>CYP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317721</externalid>
        <name>CYP2B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327678</externalid>
        <name>3-methyleneindolenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327961</externalid>
        <name>4-hydroxy-17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5643846</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40555</externalid>
        <name>paclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45863</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327966</externalid>
        <name>4-hydroxydebrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63800</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327985</externalid>
        <name>4-hydroxyphenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40653</externalid>
        <name>phenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114902</externalid>
        <name>ethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395863</externalid>
        <name>debrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34665</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327681</externalid>
        <name>3,16-dihydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915885</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327680</externalid>
        <name>12-HETE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40425</externalid>
        <name>omeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7772</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216566</externalid>
        <name>indolin-2-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39963</externalid>
        <name>loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6532</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327978</externalid>
        <name>5'-hydroxyomeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63840</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327974</externalid>
        <name>4-hydroxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42365</externalid>
        <name>skatole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9171</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395217</externalid>
        <name>6-hydroxypaclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63859</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114930</externalid>
        <name>umbelliferone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27510</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216637</externalid>
        <name>3-hydroxypalmitic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327986</externalid>
        <name>4-hydroxytolbutamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327677</externalid>
        <name>(24S)-1alpha,24,25-trihydroxyvitamin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327669</externalid>
        <name>19-hydroxyprostaglandin H2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114913</externalid>
        <name>12-hydroxylauric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>39567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39679</externalid>
        <name>cyclophosphamide hydrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30193</externalid>
        <name>1H-indole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395394</externalid>
        <name>desmethyl loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64043</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-211976</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211981</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211935</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211979</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211916</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211958</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-211897</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211976</externalid>
    <name>Endogenous sterols</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211976</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327861</externalid>
        <name>CYP19A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327705</externalid>
        <name>CYP46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389658</externalid>
        <name>CYP4V2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328219</externalid>
        <name>CYP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00191</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328226</externalid>
        <name>CYP11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317857</externalid>
        <name>AHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327834</externalid>
        <name>CYP11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328241</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317867</externalid>
        <name>ARNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317875</externalid>
        <name>AHRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327594</externalid>
        <name>CYP7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333193</externalid>
        <name>CYP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327729</externalid>
        <name>CYP39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328420</externalid>
        <name>CYP51A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327624</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34857</externalid>
        <name>7alpha-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17500</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327961</externalid>
        <name>4-hydroxy-17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37423</externalid>
        <name>11-deoxycortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48564</externalid>
        <name>4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17813</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193024</externalid>
        <name>25-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32167</externalid>
        <name>lanosterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16521</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193003</externalid>
        <name>(24S)-7alpha,24-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33139</externalid>
        <name>4-methylpentanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17998</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37437</externalid>
        <name>(20R,22R)-20,22-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31273</externalid>
        <name>18-hydroxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16485</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211976</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211981</externalid>
    <name>Xenobiotics</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211981</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317786</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317747</externalid>
        <name>CYP2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317782</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317743</externalid>
        <name>CYP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317721</externalid>
        <name>CYP2B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317852</externalid>
        <name>CYP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317857</externalid>
        <name>AHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333158</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317867</externalid>
        <name>ARNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317875</externalid>
        <name>AHRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>40425</externalid>
        <name>omeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7772</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395863</externalid>
        <name>debrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34665</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39963</externalid>
        <name>loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6532</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327678</externalid>
        <name>3-methyleneindolenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327978</externalid>
        <name>5'-hydroxyomeprazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63840</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395217</externalid>
        <name>6-hydroxypaclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63859</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114930</externalid>
        <name>umbelliferone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27510</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40555</externalid>
        <name>paclitaxel</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45863</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327966</externalid>
        <name>4-hydroxydebrisoquin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63800</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327985</externalid>
        <name>4-hydroxyphenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63804</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327974</externalid>
        <name>4-hydroxycyclophosphamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327986</externalid>
        <name>4-hydroxytolbutamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40653</externalid>
        <name>phenytoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39679</externalid>
        <name>cyclophosphamide hydrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42365</externalid>
        <name>skatole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9171</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114902</externalid>
        <name>ethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395394</externalid>
        <name>desmethyl loperamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64043</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-211957</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211999</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-211981</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211957</externalid>
    <name>Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211957</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114915</externalid>
        <name>biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1784</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211957</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211981</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211999</externalid>
    <name>CYP2E1 reactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211999</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317743</externalid>
        <name>CYP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317721</externalid>
        <name>CYP2B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317747</externalid>
        <name>CYP2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114910</externalid>
        <name>halothane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157763</externalid>
        <name>2-chlorooxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114911</externalid>
        <name>tetrachloromethane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114882</externalid>
        <name>benzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114905</externalid>
        <name>chloroethene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157757</externalid>
        <name>hydrogen bromide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47266</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157759</externalid>
        <name>trifluoroacetyl chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29884</externalid>
        <name>dihydrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18276</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211999</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211981</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211935</externalid>
    <name>Fatty acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211935</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317747</externalid>
        <name>CYP2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317782</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317721</externalid>
        <name>CYP2B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2327680</externalid>
        <name>12-HETE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916004</externalid>
        <name>5,6-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>131992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915983</externalid>
        <name>14,15-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84024</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327666</externalid>
        <name>18-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63590</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915978</externalid>
        <name>8,9-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916000</externalid>
        <name>11,12-EET(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114913</externalid>
        <name>12-hydroxylauric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>39567</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211935</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211979</externalid>
    <name>Eicosanoids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211979</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317887</externalid>
        <name>PTGIS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317894</externalid>
        <name>TBXAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915885</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12-trihydroxyicosa-5,9,14-trienoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915859</externalid>
        <name>20-hydroxy-leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327669</externalid>
        <name>19-hydroxyprostaglandin H2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5643846</externalid>
        <name>(5Z,9E,12S,14Z)-8,11,12,20-tetrahydroxyicosa-5,9,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83782</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211979</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211916</externalid>
    <name>Vitamins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211916</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333252</externalid>
        <name>CYP26B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332598</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332720</externalid>
        <name>CYP27B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333172</externalid>
        <name>CYP26C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333248</externalid>
        <name>CYP26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332703</externalid>
        <name>CYP2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31923</externalid>
        <name>calcidiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17933</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327677</externalid>
        <name>(24S)-1alpha,24,25-trihydroxyvitamin D3</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32099</externalid>
        <name>calcitriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37339</externalid>
        <name>calciol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28940</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211916</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211958</externalid>
    <name>Miscellaneous substrates</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211958</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317786</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317813</externalid>
        <name>LOC100295883</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317809</externalid>
        <name>CYP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333203</externalid>
        <name>CYP2U1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317817</externalid>
        <name>LOC507016</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317799</externalid>
        <name>CYP4A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317795</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317743</externalid>
        <name>CYP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317803</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317823</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317843</externalid>
        <name>CYP4F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>216566</externalid>
        <name>indolin-2-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327681</externalid>
        <name>3,16-dihydroxyhexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395213</externalid>
        <name>6beta-hydroxytestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34477</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915991</externalid>
        <name>19-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30193</externalid>
        <name>1H-indole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>216637</externalid>
        <name>3-hydroxypalmitic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37248</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-211958</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-217271</externalid>
    <name>FMO oxidises nucleophiles</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-217271</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320674</externalid>
        <name>FMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333766</externalid>
        <name>FMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333757</externalid>
        <name>FMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N427</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31239</externalid>
        <name>trimethylamine N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15724</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395386</externalid>
        <name>tamoxifen N-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395390</externalid>
        <name>methimazole S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114846</externalid>
        <name>trimethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18139</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-217271</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140180</externalid>
    <name>COX reactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140180</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320691</externalid>
        <name>PTGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915563</externalid>
        <name>prostaglandin H2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57405</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915542</externalid>
        <name>prostaglandin G2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164141</externalid>
        <name>hydrogen donor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672144</externalid>
        <name>hydrogen acceptor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-140180</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-140179</externalid>
    <name>Amine Oxidase reactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-140179</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321142</externalid>
        <name>PAOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321124</externalid>
        <name>MAOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321135</externalid>
        <name>SMOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35105</externalid>
        <name>(4-hydroxyphenyl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30227</externalid>
        <name>tyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-141333</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-141334</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-140179</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-141333</externalid>
    <name>Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-141333</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321124</externalid>
        <name>MAOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35105</externalid>
        <name>(4-hydroxyphenyl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15621</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30227</externalid>
        <name>tyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-141333</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140179</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-141334</externalid>
    <name>PAOs oxidise polyamines to amines</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-141334</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321142</externalid>
        <name>PAOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321135</externalid>
        <name>SMOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955579</externalid>
        <name>N(1)-acetylspermidinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58324</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760861</externalid>
        <name>N(1)-acetylsperminium(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760844</externalid>
        <name>1,4-butanediammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>326268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157762</externalid>
        <name>3-acetamidopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30322</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955568</externalid>
        <name>3-ammoniopropanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58374</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-141334</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-140179</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-71384</externalid>
    <name>Ethanol oxidation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-71384</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344888</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386967</externalid>
        <name>ADH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314253</externalid>
        <name>ACSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314235</externalid>
        <name>ALDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20000</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387893</externalid>
        <name>ALDH1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314212</externalid>
        <name>ADH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314224</externalid>
        <name>ADH7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314218</externalid>
        <name>ADH6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114774</externalid>
        <name>acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316350</externalid>
        <name>S-(hydroxymethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>acetyl-CoA(4-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-71384</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211945</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <gene>
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      <smallmolecule>
        <externalid>40879</externalid>
        <name>2,3,7,8-tetrachlorodibenzodioxine</name>
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    </smallmolecules>
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      <linkedsystem>
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          <superset />
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          <protein>
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          </protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10325806</externalid>
        <name>SULT2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325795</externalid>
        <name>SULT6B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325607</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GSTO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BED9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325647</externalid>
        <name>GSTT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325284</externalid>
        <name>AHCY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312920</externalid>
        <name>UGP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325789</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0S6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325853</externalid>
        <name>LOC100300896</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP36</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395397</externalid>
        <name>4-acetamidobenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48225</externalid>
        <name>8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114887</externalid>
        <name>purine-6-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696217</externalid>
        <name>methylarsonite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395215</externalid>
        <name>7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33603</externalid>
        <name>N-methylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33435</externalid>
        <name>taurolithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176504</externalid>
        <name>2-acetamidofluorene N-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40933</externalid>
        <name>N'-acetylisoniazid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7207</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6793344</externalid>
        <name>benzo[a]pyrene-7,8-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87752</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692223</externalid>
        <name>benzo[a]pyrene-cis-7,8-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30875</externalid>
        <name>4-nitrophenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176578</externalid>
        <name>3,3'-diiodothyronine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760977</externalid>
        <name>lithocholate sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31615</externalid>
        <name>hydrogen chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327675</externalid>
        <name>3-hydroxy-4-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696232</externalid>
        <name>dimethylarsinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176561</externalid>
        <name>4-nitrophenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395393</externalid>
        <name>4-acetamidosalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29788</externalid>
        <name>3,4-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176607</externalid>
        <name>26-hydroxycholesterol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30379</externalid>
        <name>4-aminobenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760983</externalid>
        <name>cholesterol sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760413</externalid>
        <name>mycophenolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176612</externalid>
        <name>3,3',5-triiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6800152</externalid>
        <name>dimethylarsinic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48765</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395385</externalid>
        <name>sulfacetamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694576</externalid>
        <name>mycophenolic acid O-acyl-glucuronide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39913</externalid>
        <name>isoniazide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6030</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316406</externalid>
        <name>arsenite(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760978</externalid>
        <name>S-(2,4-dinitrophenyl)glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176590</externalid>
        <name>N-hydroxy-2-acetamidofluorene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>183157</externalid>
        <name>5-acetamido-6-formamido-3-methyluracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166608</externalid>
        <name>S-(2-hydroxyethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166605</externalid>
        <name>dopamine 3-O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114908</externalid>
        <name>sulfanilamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176506</externalid>
        <name>pregnenolone sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760789</externalid>
        <name>methylarsonate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796683</externalid>
        <name>L-cysteinylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166419</externalid>
        <name>N-hydroxy-4-aminobiphenyl O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32701</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166417</externalid>
        <name>benzo[a]pyrene diol epoxide I</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166587</externalid>
        <name>phenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114859</externalid>
        <name>pyridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176589</externalid>
        <name>3,3'-diiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695956</externalid>
        <name>p-nitrophenyl butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85867</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163084</externalid>
        <name>1-chloro-2,4-dinitrobenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34718</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796682</externalid>
        <name>5-oxo-L-prolinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33333</externalid>
        <name>4-aminosalicylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40379</externalid>
        <name>methylarsonous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17826</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760924</externalid>
        <name>L-gamma-glutamyl-L-cysteinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42447</externalid>
        <name>17beta-estradiol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166420</externalid>
        <name>N-acetoxy-1,1'-biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-156588</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156584</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156582</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156581</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156590</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156587</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-156580</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211859</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156588</externalid>
    <name>Glucuronidation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156588</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400684</externalid>
        <name>UXS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324786</externalid>
        <name>UGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12378</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387808</externalid>
        <name>ABHD10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312920</externalid>
        <name>UGP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325214</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694576</externalid>
        <name>mycophenolic acid O-acyl-glucuronide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760413</externalid>
        <name>mycophenolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661255</externalid>
        <name>D-glucuronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15748</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-173599</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-156588</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-173599</externalid>
    <name>Formation of the active cofactor, UDP-glucuronate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-173599</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400684</externalid>
        <name>UXS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324786</externalid>
        <name>UGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12378</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312920</externalid>
        <name>UGP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07130</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325214</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-173599</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156588</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156584</externalid>
    <name>Cytosolic sulfonation of small molecules</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156584</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325771</externalid>
        <name>SULT1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325839</externalid>
        <name>BPNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325823</externalid>
        <name>SULT4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407009</externalid>
        <name>PODXL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325806</externalid>
        <name>SULT2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407021</externalid>
        <name>TPST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321853</externalid>
        <name>SULT1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325795</externalid>
        <name>SULT6B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325783</externalid>
        <name>SULT1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407017</externalid>
        <name>TPST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406920</externalid>
        <name>BPNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387822</externalid>
        <name>ABHD14B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325789</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325853</externalid>
        <name>LOC100300896</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325777</externalid>
        <name>SULT1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32507</externalid>
        <name>pregnenolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176612</externalid>
        <name>3,3',5-triiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166419</externalid>
        <name>N-hydroxy-4-aminobiphenyl O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32701</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31451</externalid>
        <name>dehydroepiandrosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166587</externalid>
        <name>phenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33435</externalid>
        <name>taurolithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176504</externalid>
        <name>2-acetamidofluorene N-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176589</externalid>
        <name>3,3'-diiodo-L-thyronine sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5695956</externalid>
        <name>p-nitrophenyl butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85867</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176590</externalid>
        <name>N-hydroxy-2-acetamidofluorene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30875</externalid>
        <name>4-nitrophenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760977</externalid>
        <name>lithocholate sulfate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133940</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176578</externalid>
        <name>3,3'-diiodothyronine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35430</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176607</externalid>
        <name>26-hydroxycholesterol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114792</externalid>
        <name>phenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760983</externalid>
        <name>cholesterol sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176561</externalid>
        <name>4-nitrophenyl hydrogen sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166605</externalid>
        <name>dopamine 3-O-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37946</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38625</externalid>
        <name>26-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42447</externalid>
        <name>17beta-estradiol 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176506</externalid>
        <name>pregnenolone sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-156584</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156582</externalid>
    <name>Acetylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156582</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321987</externalid>
        <name>NAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395393</externalid>
        <name>4-acetamidosalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>183157</externalid>
        <name>5-acetamido-6-formamido-3-methyluracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114928</externalid>
        <name>1,7-dimethylxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25858</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395385</externalid>
        <name>sulfacetamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63845</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395397</externalid>
        <name>4-acetamidobenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114893</externalid>
        <name>N-hydroxy-4-aminobiphenyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33333</externalid>
        <name>4-aminosalicylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30379</externalid>
        <name>4-aminobenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39913</externalid>
        <name>isoniazide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>6030</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40933</externalid>
        <name>N'-acetylisoniazid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7207</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114908</externalid>
        <name>sulfanilamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45373</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166420</externalid>
        <name>N-acetoxy-1,1'-biphenyl-4-amine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16395</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-156582</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156581</externalid>
    <name>Methylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156581</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325629</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393794</externalid>
        <name>N6AMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R0T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393798</externalid>
        <name>TRMT112</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325257</externalid>
        <name>MAT1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325229</externalid>
        <name>MTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325564</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325284</externalid>
        <name>AHCY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325223</externalid>
        <name>MTRR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321899</externalid>
        <name>TPMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387950</externalid>
        <name>AS3MT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N140</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325557</externalid>
        <name>COMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6800152</externalid>
        <name>dimethylarsinic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48765</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114887</externalid>
        <name>purine-6-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696217</externalid>
        <name>methylarsonite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14597</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33603</externalid>
        <name>N-methylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114859</externalid>
        <name>pyridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16227</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316406</externalid>
        <name>arsenite(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29242</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759437</externalid>
        <name>cob(I)alamin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60488</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29788</externalid>
        <name>3,4-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36062</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5696232</externalid>
        <name>dimethylarsinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327675</externalid>
        <name>3-hydroxy-4-methoxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3149504</externalid>
        <name>methylcobalamin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40379</externalid>
        <name>methylarsonous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17826</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760789</externalid>
        <name>methylarsonate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-156581</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156590</externalid>
    <name>Glutathione conjugation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156590</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325615</externalid>
        <name>GSTM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354419</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354401</externalid>
        <name>CNDP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325678</externalid>
        <name>MGST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325690</externalid>
        <name>MGST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382424</externalid>
        <name>AKR1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354410</externalid>
        <name>GGCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325655</externalid>
        <name>HPGDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371502</externalid>
        <name>GSTK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325597</externalid>
        <name>GSTM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325684</externalid>
        <name>MGST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325641</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334159</externalid>
        <name>GGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378911</externalid>
        <name>GGT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325201</externalid>
        <name>GCLC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325603</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325629</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389462</externalid>
        <name>CHAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325275</externalid>
        <name>GSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325571</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325583</externalid>
        <name>GSTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387329</externalid>
        <name>ESD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325591</externalid>
        <name>GSTA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389458</externalid>
        <name>CHAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H738</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325607</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325647</externalid>
        <name>GSTT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325635</externalid>
        <name>GSTO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BED9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325205</externalid>
        <name>GCLM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9796683</externalid>
        <name>L-cysteinylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48225</externalid>
        <name>8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166417</externalid>
        <name>benzo[a]pyrene diol epoxide I</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395215</externalid>
        <name>7,8-dihydro-7-hydroxy-8S-glutathionylbenzo[a]pyrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6793344</externalid>
        <name>benzo[a]pyrene-7,8-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87752</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760978</externalid>
        <name>S-(2,4-dinitrophenyl)glutathione(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5692223</externalid>
        <name>benzo[a]pyrene-cis-7,8-dihydrodiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>81626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114903</externalid>
        <name>oxirane</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27561</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163084</externalid>
        <name>1-chloro-2,4-dinitrobenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34718</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796682</externalid>
        <name>5-oxo-L-prolinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31615</externalid>
        <name>hydrogen chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157764</externalid>
        <name>N-acetyl-1,4-benzoquinone imine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29132</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31125</externalid>
        <name>S-formylglutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166608</externalid>
        <name>S-(2-hydroxyethyl)glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760924</externalid>
        <name>L-gamma-glutamyl-L-cysteinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-174403</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-156590</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174403</externalid>
    <name>Glutathione synthesis and recycling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174403</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325201</externalid>
        <name>GCLC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378911</externalid>
        <name>GGT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389458</externalid>
        <name>CHAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H738</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389462</externalid>
        <name>CHAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325275</externalid>
        <name>GSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325205</externalid>
        <name>GCLM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354419</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354401</externalid>
        <name>CNDP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354410</externalid>
        <name>GGCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334159</externalid>
        <name>GGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9796683</externalid>
        <name>L-cysteinylglycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796682</externalid>
        <name>5-oxo-L-prolinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760924</externalid>
        <name>L-gamma-glutamyl-L-cysteinate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58173</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174403</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156590</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156587</externalid>
    <name>Amino Acid conjugation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156587</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322124</externalid>
        <name>GLYATL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322128</externalid>
        <name>GLYATL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322141</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322111</externalid>
        <name>ACSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-159424</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-156587</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159424</externalid>
    <name>Conjugation of carboxylic acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159424</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322124</externalid>
        <name>GLYATL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322128</externalid>
        <name>GLYATL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322141</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322111</externalid>
        <name>ACSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-177135</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177162</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177128</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-159424</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156587</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-177135</externalid>
    <name>Conjugation of benzoate with glycine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-177135</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322124</externalid>
        <name>GLYATL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322128</externalid>
        <name>GLYATL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322111</externalid>
        <name>ACSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760747</externalid>
        <name>benzoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57369</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760897</externalid>
        <name>N-benzoylglycinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29696</externalid>
        <name>benzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30746</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-177135</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159424</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-177162</externalid>
    <name>Conjugation of phenylacetate with glutamine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-177162</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322111</externalid>
        <name>ACSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760751</externalid>
        <name>phenylacetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57390</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30345</externalid>
        <name>phenyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8082</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-177162</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159424</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-177128</externalid>
    <name>Conjugation of salicylate with glycine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-177128</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322124</externalid>
        <name>GLYATL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322128</externalid>
        <name>GLYATL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322141</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166422</externalid>
        <name>2-hydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-177128</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159424</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5423646</externalid>
    <name>Aflatoxin activation and detoxification</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5423646</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10378911</externalid>
        <name>GGT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378846</externalid>
        <name>AKR7A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325678</externalid>
        <name>MGST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378838</externalid>
        <name>AKR7A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325690</externalid>
        <name>MGST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317760</externalid>
        <name>CYP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334142</externalid>
        <name>DPEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317751</externalid>
        <name>CYP2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325684</externalid>
        <name>MGST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378928</externalid>
        <name>ACY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334148</externalid>
        <name>DPEP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334159</externalid>
        <name>GGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490349</externalid>
        <name>Aflatoxin B1 endo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490350</externalid>
        <name>Aflatoxin B1 exo-cysteinylglycine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490346</externalid>
        <name>Aflatoxin B1 endo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39421</externalid>
        <name>aflatoxin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490357</externalid>
        <name>Aflatoxin B1 exo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5618013</externalid>
        <name>aflatoxin B1 triol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490359</externalid>
        <name>Aflatoxin B1 endo glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78581</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490343</externalid>
        <name>aflatoxin B1 dialdehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53107</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490347</externalid>
        <name>Aflatoxin B1 endo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78578</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490353</externalid>
        <name>aflatoxin M1 8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78577</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>622409</externalid>
        <name>aflatoxin B1 exo-8,9-epoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490352</externalid>
        <name>Aflatoxin B1 exo-N-acetylcysteine conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490358</externalid>
        <name>Aflatoxin B1 exo-cysteinyl-conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78583</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490356</externalid>
        <name>aflatoxin Q1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490351</externalid>
        <name>aflatoxin B1 endo-8,9-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78586</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5490348</externalid>
        <name>aflatoxin M1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78576</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5423646</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-211859</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1362409</externalid>
    <name>Mitochondrial iron-sulfur cluster biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1362409</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10403286</externalid>
        <name>ISCA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403282</externalid>
        <name>ISCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389832</externalid>
        <name>HSCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355371</externalid>
        <name>FXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403276</externalid>
        <name>GLRX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349375</externalid>
        <name>NFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355363</externalid>
        <name>ISCU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355367</externalid>
        <name>LYRM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2395516</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1362409</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2395516</externalid>
    <name>Electron transport from NADPH to Ferredoxin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2395516</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327848</externalid>
        <name>FDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327838</externalid>
        <name>FDXR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327842</externalid>
        <name>FDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759578</externalid>
        <name>FADH2(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58307</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2395516</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1362409</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Reversible hydration of carbon dioxide</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CA7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BHA4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356617</externalid>
        <name>CA3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SZX4</externalid>
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          </protein>
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      <gene>
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        <name>CA4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CA1</name>
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          <protein>
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              <externalid>Q1LZA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CA5B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1BHD3</externalid>
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      <gene>
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      <gene>
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        <name>CA9</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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        <name>hydrogencarbonate</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-1475029</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1430728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <taxnode>
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        <name>PPA2</name>
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          <protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>magnesium(2+)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      <gene>
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          </protein>
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      <gene>
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        <name>CP</name>
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          <protein>
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              <externalid>F1N076</externalid>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MD24</externalid>
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          </protein>
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      <smallmolecule>
        <externalid>114783</externalid>
        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15956</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395896</externalid>
        <name>4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5340139</externalid>
        <name>calcium phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164164</externalid>
        <name>cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36916</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942697</externalid>
        <name>dipeptide zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5340322</externalid>
        <name>glycosphingolipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24402</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36937</externalid>
        <name>porphyrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8337</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114862</externalid>
        <name>creatinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>433682</externalid>
        <name>3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37054</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>446593</externalid>
        <name>tetramethylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1638844</externalid>
        <name>N-acylsphingosine 1-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16197</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48285</externalid>
        <name>N-methyl-4-phenylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969927</externalid>
        <name>p-aminohippurate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842008</externalid>
        <name>beta-D-glucosyl-N-acylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>22801</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1454914</externalid>
        <name>organic anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42379</externalid>
        <name>tetracosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35265</externalid>
        <name>N(omega)-methyl-L-arginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28229</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39695</externalid>
        <name>desipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47781</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9931185</externalid>
        <name>guanidinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5252032</externalid>
        <name>divalent metal cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40101</externalid>
        <name>metformin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90688</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8959786</externalid>
        <name>L-homoarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39903</externalid>
        <name>imipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395214</externalid>
        <name>bromosulfophthalein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5691104</externalid>
        <name>iron(III) oxide-hydroxide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78619</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8857685</externalid>
        <name>glycerophospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955302</externalid>
        <name>estrone 3-sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018644</externalid>
        <name>oxaliplatin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157767</externalid>
        <name>electron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429607</externalid>
        <name>1D-chiro-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30479</externalid>
        <name>2,5-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40569</externalid>
        <name>procainamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>265457</externalid>
        <name>phytosterols</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38769</externalid>
        <name>icosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28822</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36539</externalid>
        <name>prostaglandin E1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9958569</externalid>
        <name>ergothioneine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942695</externalid>
        <name>tripeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879577</externalid>
        <name>digoxin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30056</externalid>
        <name>cytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018640</externalid>
        <name>clonidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841055</externalid>
        <name>galactosylceramide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36498</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672372</externalid>
        <name>non-steroidal anti-inflammatory drug</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2730675</externalid>
        <name>nicotinic acid-adenine dinucleotide phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76072</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955599</externalid>
        <name>dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30629</externalid>
        <name>lipoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29608</externalid>
        <name>D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15570</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-382556</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445717</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-917937</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983712</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1480926</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5223345</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8949215</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174824</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8981607</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9845576</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-382551</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-382556</externalid>
    <name>ABC-family proteins mediated transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-382556</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334095</externalid>
        <name>KCNJ11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356239</externalid>
        <name>ABCG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z044</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338729</externalid>
        <name>PEX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1454914</externalid>
        <name>organic anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>265457</externalid>
        <name>phytosterols</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36937</externalid>
        <name>porphyrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8337</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1369062</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1369007</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-382556</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1369062</externalid>
    <name>ABC transporters in lipid homeostasis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1369062</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10398104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338716</externalid>
        <name>ABCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z038</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384078</externalid>
        <name>ABCA12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E556</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338710</externalid>
        <name>ABCD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RLQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384314</externalid>
        <name>ABCA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338704</externalid>
        <name>ABCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356239</externalid>
        <name>ABCG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z044</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338729</externalid>
        <name>PEX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334129</externalid>
        <name>ABCG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334133</externalid>
        <name>ABCG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338749</externalid>
        <name>PEX19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>265457</externalid>
        <name>phytosterols</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1369062</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1369007</externalid>
    <name>Mitochondrial ABC transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1369007</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338687</externalid>
        <name>ABCB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338693</externalid>
        <name>ABCB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355444</externalid>
        <name>ABCB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36937</externalid>
        <name>porphyrin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8337</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1369007</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425407</externalid>
    <name>SLC-mediated transmembrane transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425407</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342432</externalid>
        <name>SLC2A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341741</externalid>
        <name>SLC9A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343322</externalid>
        <name>SLC47A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328930</externalid>
        <name>SLC2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342318</externalid>
        <name>SLC32A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N354</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343485</externalid>
        <name>SLC39A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322706</externalid>
        <name>SLC25A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32007</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343253</externalid>
        <name>SLC13A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346699</externalid>
        <name>SLC22A16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341634</externalid>
        <name>SLC4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342377</externalid>
        <name>SLC2A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341745</externalid>
        <name>SLC9A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E545</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335758</externalid>
        <name>SLC7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342049</externalid>
        <name>SLC34A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323248</externalid>
        <name>SLC22A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334660</externalid>
        <name>SLC38A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347499</externalid>
        <name>SLCO4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342425</externalid>
        <name>SLC2A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343675</externalid>
        <name>SLC6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341673</externalid>
        <name>SLC8A1</name>
        <entity>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>SLC12A6</name>
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          </protein>
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      </gene>
      <gene>
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        <name>SLC6A13</name>
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              <externalid>A5PJX7</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q3SZP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC38A1</name>
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          <protein>
            <xref>
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              <externalid>F1MTX9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC45A3</name>
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              <externalid>E1BMB9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MUT8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>SLC22A7</name>
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            <xref>
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              <externalid>F1MGH8</externalid>
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          </protein>
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      <gene>
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        <name>SLC30A10</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>SLC20A2</name>
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          <protein>
            <xref>
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              <externalid>F1N4U1</externalid>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>AHCYL2</name>
        <entity>
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            <xref>
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              <externalid>A6QLP2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SLC7A9</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
        <externalid>10347495</externalid>
        <name>SLCO1C1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC23</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342042</externalid>
        <name>SLC34A3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3MXY5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341681</externalid>
        <name>SLC8A3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST7</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10329722</externalid>
        <name>PDZD11</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346689</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347065</externalid>
        <name>SLC33A1</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC39A7</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SLC9A8</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SLC12A2</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC4A2</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
        <externalid>10346684</externalid>
        <name>SLC22A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341647</externalid>
        <name>SLC4A7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CP</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SLC22A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SLC25A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SLC26A9</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SLC5A1</name>
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          <protein>
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          </protein>
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        <name>biotin</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>1-methylnicotinamide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395896</externalid>
        <name>4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
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      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395214</externalid>
        <name>bromosulfophthalein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63836</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942697</externalid>
        <name>dipeptide zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90799</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114862</externalid>
        <name>creatinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>433682</externalid>
        <name>3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37054</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>446593</externalid>
        <name>tetramethylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955302</externalid>
        <name>estrone 3-sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018644</externalid>
        <name>oxaliplatin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48285</externalid>
        <name>N-methyl-4-phenylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429607</externalid>
        <name>1D-chiro-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969927</externalid>
        <name>p-aminohippurate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40569</externalid>
        <name>procainamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38769</externalid>
        <name>icosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28822</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36539</externalid>
        <name>prostaglandin E1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9958569</externalid>
        <name>ergothioneine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1454914</externalid>
        <name>organic anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42379</externalid>
        <name>tetracosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942695</externalid>
        <name>tripeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879577</externalid>
        <name>digoxin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35265</externalid>
        <name>N(omega)-methyl-L-arginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28229</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30056</externalid>
        <name>cytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018640</externalid>
        <name>clonidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39695</externalid>
        <name>desipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47781</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9931185</externalid>
        <name>guanidinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40101</externalid>
        <name>metformin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90688</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8959786</externalid>
        <name>L-homoarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955599</externalid>
        <name>dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39903</externalid>
        <name>imipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30629</externalid>
        <name>lipoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29608</externalid>
        <name>D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15570</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-425410</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-549127</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442660</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958863</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9959399</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-189200</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-429593</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425397</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-425407</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425410</externalid>
    <name>Metal ion SLC transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425410</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341700</externalid>
        <name>SLC24A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341741</externalid>
        <name>SLC9A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343527</externalid>
        <name>SLC39A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407333</externalid>
        <name>SLC30A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343485</externalid>
        <name>SLC39A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343539</externalid>
        <name>SLC39A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1KZG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341770</externalid>
        <name>SLC9A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343400</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341734</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341677</externalid>
        <name>SLC8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341704</externalid>
        <name>SLC24A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341745</externalid>
        <name>SLC9A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E545</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343489</externalid>
        <name>SLC39A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343502</externalid>
        <name>SLC40A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341708</externalid>
        <name>SLC24A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343372</externalid>
        <name>SLC30A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B955</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343548</externalid>
        <name>SLC41A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343552</externalid>
        <name>SLC41A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343358</externalid>
        <name>SLC11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341681</externalid>
        <name>SLC8A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380797</externalid>
        <name>SLC24A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341696</externalid>
        <name>SLC24A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343365</externalid>
        <name>SLC30A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343381</externalid>
        <name>SLC30A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N919</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343511</externalid>
        <name>SLC39A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341754</externalid>
        <name>SLC9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343520</externalid>
        <name>SLC39A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341673</externalid>
        <name>SLC8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341781</externalid>
        <name>SLC9A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343348</externalid>
        <name>SLC11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343498</externalid>
        <name>HEPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341762</externalid>
        <name>SLC9A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343535</externalid>
        <name>SLC39A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341766</externalid>
        <name>SLC9A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347778</externalid>
        <name>CP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N076</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341758</externalid>
        <name>SLC9A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341717</externalid>
        <name>SLC8B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343531</externalid>
        <name>SLC39A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-425986</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425561</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-435354</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-425410</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425986</externalid>
    <name>Sodium/Proton exchangers</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425986</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341762</externalid>
        <name>SLC9A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341741</externalid>
        <name>SLC9A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341734</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341745</externalid>
        <name>SLC9A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E545</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341766</externalid>
        <name>SLC9A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341754</externalid>
        <name>SLC9A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341758</externalid>
        <name>SLC9A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341781</externalid>
        <name>SLC9A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341770</externalid>
        <name>SLC9A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-425986</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425410</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425561</externalid>
    <name>Sodium/Calcium exchangers</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425561</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341700</externalid>
        <name>SLC24A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380797</externalid>
        <name>SLC24A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341696</externalid>
        <name>SLC24A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341677</externalid>
        <name>SLC8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341704</externalid>
        <name>SLC24A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341708</externalid>
        <name>SLC24A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341717</externalid>
        <name>SLC8B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341673</externalid>
        <name>SLC8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341681</externalid>
        <name>SLC8A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>425811</externalid>
        <name>lithium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49713</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-425561</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <organism_specific_biosystem />
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      <gene>
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      <smallmolecule>
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        <name>zinc(2+)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydron</name>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442380</externalid>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341643</externalid>
        <name>SLC4A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342020</externalid>
        <name>SLC26A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-425381</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-433137</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-426117</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-427601</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-427652</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9958790</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425381</externalid>
    <name>Bicarbonate transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425381</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341651</externalid>
        <name>SLC4A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341630</externalid>
        <name>SLC4A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M051</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341664</externalid>
        <name>SLC4A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341634</externalid>
        <name>SLC4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341660</externalid>
        <name>SLC4A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341647</externalid>
        <name>SLC4A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403260</externalid>
        <name>AHCYL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341626</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QPG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341643</externalid>
        <name>SLC4A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403255</externalid>
        <name>SLC4A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-425381</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-433137</externalid>
    <name>Sodium-coupled sulphate, di- and tri-carboxylate transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-433137</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343225</externalid>
        <name>SLC13A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R7G2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343246</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-433137</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-426117</externalid>
    <name>Cation-coupled Chloride cotransporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-426117</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341834</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341842</externalid>
        <name>SLC12A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NIV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341830</externalid>
        <name>SLC12A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341810</externalid>
        <name>SLC12A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341823</externalid>
        <name>SLC12A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341814</externalid>
        <name>SLC12A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341838</externalid>
        <name>SLC12A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2X1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-426117</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-427601</externalid>
    <name>Inorganic anion exchange by SLC26 transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-427601</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10380965</externalid>
        <name>SLC26A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342007</externalid>
        <name>SLC26A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342016</externalid>
        <name>SLC26A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342003</externalid>
        <name>SLC26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3P2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342066</externalid>
        <name>SLC26A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402710</externalid>
        <name>SLC26A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342062</externalid>
        <name>SLC26A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N207</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342020</externalid>
        <name>SLC26A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316213</externalid>
        <name>oxalate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162876</externalid>
        <name>thiosulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33541</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-427601</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-427652</externalid>
    <name>Sodium-coupled phosphate cotransporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-427652</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342033</externalid>
        <name>SLC20A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342311</externalid>
        <name>SLC17A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M176</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342029</externalid>
        <name>SLC20A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342042</externalid>
        <name>SLC34A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342049</externalid>
        <name>SLC34A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342053</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-427589</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-427652</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958790</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-427589</externalid>
    <name>Type II Na+/Pi cotransporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-427589</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342042</externalid>
        <name>SLC34A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342049</externalid>
        <name>SLC34A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342053</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-427589</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-427652</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-549127</externalid>
    <name>SLC-mediated transport of organic cations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-549127</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323248</externalid>
        <name>SLC22A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343322</externalid>
        <name>SLC47A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346712</externalid>
        <name>SLC22A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343709</externalid>
        <name>SLC14A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5QF96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399924</externalid>
        <name>SLC25A26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346689</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346703</externalid>
        <name>SLC22A15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8T2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346684</externalid>
        <name>SLC22A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346699</externalid>
        <name>SLC22A16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343713</externalid>
        <name>SLC14A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346789</externalid>
        <name>SLC22A18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>33879</externalid>
        <name>1-methylnicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16797</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760865</externalid>
        <name>agmatinium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58145</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395896</externalid>
        <name>4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40569</externalid>
        <name>procainamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8428</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114862</externalid>
        <name>creatinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39695</externalid>
        <name>desipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47781</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9931185</externalid>
        <name>guanidinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9958569</externalid>
        <name>ergothioneine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>134344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>446593</externalid>
        <name>tetramethylammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40101</externalid>
        <name>metformin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90688</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018644</externalid>
        <name>oxaliplatin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760746</externalid>
        <name>spermine(4+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48285</externalid>
        <name>N-methyl-4-phenylpyridinium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39903</externalid>
        <name>imipramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2018640</externalid>
        <name>clonidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46631</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29952</externalid>
        <name>(R)-carnitine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-549127</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9955298</externalid>
    <name>SLC-mediated transport of organic anions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9955298</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343239</externalid>
        <name>SLC13A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343260</externalid>
        <name>SLC16A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2EF45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347520</externalid>
        <name>SLCO3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343753</externalid>
        <name>SLC44A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347544</externalid>
        <name>SLCO4C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346757</externalid>
        <name>SLC22A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334900</externalid>
        <name>SLC25A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343218</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343253</externalid>
        <name>SLC13A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347495</externalid>
        <name>SLCO1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342591</externalid>
        <name>SMCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C8KIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343757</externalid>
        <name>SLC44A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347503</externalid>
        <name>SLC16A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317366</externalid>
        <name>SLC25A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346732</externalid>
        <name>SLC22A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347499</externalid>
        <name>SLCO4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402831</externalid>
        <name>SLC5A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346736</externalid>
        <name>LOC519202</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328791</externalid>
        <name>SLC25A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22292</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343761</externalid>
        <name>SLC44A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346768</externalid>
        <name>SLC22A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343749</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343232</externalid>
        <name>SLC13A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4I3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342509</externalid>
        <name>SLC5A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336221</externalid>
        <name>AVP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347481</externalid>
        <name>SLCO2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346746</externalid>
        <name>SLC22A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346742</externalid>
        <name>SLC22A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328289</externalid>
        <name>SLCO1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343765</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5M4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343264</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>433682</externalid>
        <name>3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37054</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395214</externalid>
        <name>bromosulfophthalein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36539</externalid>
        <name>prostaglandin E1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1454914</externalid>
        <name>organic anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955302</externalid>
        <name>estrone 3-sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879577</externalid>
        <name>digoxin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969927</externalid>
        <name>p-aminohippurate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-879518</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-561048</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428643</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-433692</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9955298</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-879518</externalid>
    <name>Organic anion transport by SLCO transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-879518</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347503</externalid>
        <name>SLC16A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347520</externalid>
        <name>SLCO3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347544</externalid>
        <name>SLCO4C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347499</externalid>
        <name>SLCO4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336221</externalid>
        <name>AVP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347495</externalid>
        <name>SLCO1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347481</externalid>
        <name>SLCO2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328289</externalid>
        <name>SLCO1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34697</externalid>
        <name>taurochenodeoxycholic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16525</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955302</externalid>
        <name>estrone 3-sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955305</externalid>
        <name>L-thyroxine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58448</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760903</externalid>
        <name>taurocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37379</externalid>
        <name>taurochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9407</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879577</externalid>
        <name>digoxin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395214</externalid>
        <name>bromosulfophthalein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9965896</externalid>
        <name>3,3',5-triiodo-L-thyronine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>533015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36539</externalid>
        <name>prostaglandin E1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760909</externalid>
        <name>glycocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760987</externalid>
        <name>glycochenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36252</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-879518</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9958517</externalid>
    <name>SLC-mediated bile acid transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9958517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343749</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343753</externalid>
        <name>SLC44A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342509</externalid>
        <name>SLC5A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343218</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343757</externalid>
        <name>SLC44A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343761</externalid>
        <name>SLC44A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343765</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5M4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>176509</externalid>
        <name>taurolithocholic acid sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17864</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9958517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-561048</externalid>
    <name>Organic anion transport by SLC22 transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-561048</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346732</externalid>
        <name>SLC22A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346757</externalid>
        <name>SLC22A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346736</externalid>
        <name>LOC519202</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346746</externalid>
        <name>SLC22A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346742</externalid>
        <name>SLC22A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346768</externalid>
        <name>SLC22A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760853</externalid>
        <name>dehydroepiandrosterone sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9955302</externalid>
        <name>estrone 3-sulfate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60050</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9969927</externalid>
        <name>p-aminohippurate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64703</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39439</externalid>
        <name>acyclovir</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33365</externalid>
        <name>estrone 3-sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-561048</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-428643</externalid>
    <name>Organic anion transport by SLC5/17/25 transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-428643</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317366</externalid>
        <name>SLC25A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402831</externalid>
        <name>SLC5A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342591</externalid>
        <name>SMCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C8KIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334900</externalid>
        <name>SLC25A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328791</externalid>
        <name>SLC25A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22292</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1454914</externalid>
        <name>organic anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29462</externalid>
        <name>sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317126</externalid>
        <name>(S)-malate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317070</externalid>
        <name>citrate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16947</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-428643</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-433692</externalid>
    <name>Proton-coupled monocarboxylate transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-433692</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343260</externalid>
        <name>SLC16A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2EF45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343264</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>573398</externalid>
        <name>acetoacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114796</externalid>
        <name>acetoacetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>433682</externalid>
        <name>3-hydroxybutyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37054</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317527</externalid>
        <name>(S)-lactate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-433692</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9955298</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-442660</externalid>
    <name>SLC-mediated transport of neurotransmitters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-442660</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10329991</externalid>
        <name>SLC6A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343679</externalid>
        <name>SLC6A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342136</externalid>
        <name>SLC17A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402668</externalid>
        <name>SLC25A22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332903</externalid>
        <name>SLC17A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342318</externalid>
        <name>SLC32A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N354</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343675</externalid>
        <name>SLC6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334613</externalid>
        <name>SLC6A20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334620</externalid>
        <name>SLC6A15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329983</externalid>
        <name>SLC6A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337978</externalid>
        <name>SLC6A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335744</externalid>
        <name>SLC6A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342140</externalid>
        <name>SLC17A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343700</externalid>
        <name>SLC6A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343668</externalid>
        <name>SLC6A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335737</externalid>
        <name>SLC6A19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337134</externalid>
        <name>SLC6A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-442660</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9958863</externalid>
    <name>SLC-mediated transport of amino acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9958863</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335577</externalid>
        <name>SLC7A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335723</externalid>
        <name>SLC36A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334634</externalid>
        <name>SLC43A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335583</externalid>
        <name>SLC7A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N179</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332832</externalid>
        <name>SLC1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335589</externalid>
        <name>SLC7A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335730</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407326</externalid>
        <name>SLC25A29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334613</externalid>
        <name>SLC6A20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334620</externalid>
        <name>SLC6A15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334678</externalid>
        <name>SLC7A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333549</externalid>
        <name>SLC38A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334674</externalid>
        <name>SLC3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334646</externalid>
        <name>SLC38A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332828</externalid>
        <name>SLC1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335601</externalid>
        <name>SLC7A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335744</externalid>
        <name>SLC6A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334719</externalid>
        <name>SLC1A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95JC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335758</externalid>
        <name>SLC7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335595</externalid>
        <name>SLC7A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334660</externalid>
        <name>SLC38A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333542</externalid>
        <name>SLC38A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334627</externalid>
        <name>SLC43A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334687</externalid>
        <name>SLC7A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NNN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332844</externalid>
        <name>SLC1A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334653</externalid>
        <name>SLC16A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334706</externalid>
        <name>SLC1A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401789</externalid>
        <name>SLC36A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334667</externalid>
        <name>SLC38A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337149</externalid>
        <name>SLC3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335751</externalid>
        <name>SLC7A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332840</externalid>
        <name>SLC1A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334603</externalid>
        <name>SLC6A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332836</externalid>
        <name>SLC1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335737</externalid>
        <name>SLC6A19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9930606</externalid>
        <name>D-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29990</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8959786</externalid>
        <name>L-homoarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35265</externalid>
        <name>N(omega)-methyl-L-arginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28229</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29608</externalid>
        <name>D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15570</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-352230</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-428559</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9958863</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-352230</externalid>
    <name>Amino acid transport across the plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-352230</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335577</externalid>
        <name>SLC7A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335723</externalid>
        <name>SLC36A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334634</externalid>
        <name>SLC43A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335583</externalid>
        <name>SLC7A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N179</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335589</externalid>
        <name>SLC7A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335730</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407326</externalid>
        <name>SLC25A29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334613</externalid>
        <name>SLC6A20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334620</externalid>
        <name>SLC6A15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334678</externalid>
        <name>SLC7A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333549</externalid>
        <name>SLC38A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334674</externalid>
        <name>SLC3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334646</externalid>
        <name>SLC38A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335601</externalid>
        <name>SLC7A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335744</externalid>
        <name>SLC6A14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334719</externalid>
        <name>SLC1A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95JC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335758</externalid>
        <name>SLC7A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335595</externalid>
        <name>SLC7A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334660</externalid>
        <name>SLC38A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333542</externalid>
        <name>SLC38A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334627</externalid>
        <name>SLC43A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334687</externalid>
        <name>SLC7A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NNN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334653</externalid>
        <name>SLC16A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334706</externalid>
        <name>SLC1A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401789</externalid>
        <name>SLC36A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334667</externalid>
        <name>SLC38A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337149</externalid>
        <name>SLC3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335751</externalid>
        <name>SLC7A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334603</externalid>
        <name>SLC6A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335737</externalid>
        <name>SLC6A19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943636</externalid>
        <name>L-tryptophan zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57912</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943583</externalid>
        <name>L-asparagine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58048</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943643</externalid>
        <name>L-valine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760795</externalid>
        <name>taurine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>507393</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943630</externalid>
        <name>L-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943624</externalid>
        <name>L-phenylalanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58095</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943639</externalid>
        <name>L-tyrosine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58315</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8959786</externalid>
        <name>L-homoarginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317513</externalid>
        <name>trans-4-hydroxy-L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58375</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35265</externalid>
        <name>N(omega)-methyl-L-arginine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28229</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943612</externalid>
        <name>L-isoleucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58045</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29608</externalid>
        <name>D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15570</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-352230</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958863</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-428559</externalid>
    <name>Proton-coupled neutral amino acid transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-428559</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335723</externalid>
        <name>SLC36A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335730</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943627</externalid>
        <name>L-proline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942719</externalid>
        <name>L-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57972</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-428559</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9958863</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9959399</externalid>
    <name>SLC-mediated transport of oligopeptides</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9959399</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342119</externalid>
        <name>SLC15A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342112</externalid>
        <name>SLC15A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377973</externalid>
        <name>CTNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342123</externalid>
        <name>SLC15A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955599</externalid>
        <name>dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942695</externalid>
        <name>tripeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942697</externalid>
        <name>dipeptide zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90799</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-427975</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9959399</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-427975</externalid>
    <name>Proton/oligopeptide cotransporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-427975</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342119</externalid>
        <name>SLC15A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342112</externalid>
        <name>SLC15A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342123</externalid>
        <name>SLC15A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8955599</externalid>
        <name>dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942695</externalid>
        <name>tripeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942697</externalid>
        <name>dipeptide zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90799</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-427975</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9959399</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-189200</externalid>
    <name>Cellular hexose transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-189200</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342444</externalid>
        <name>SLC2A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342432</externalid>
        <name>SLC2A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342516</externalid>
        <name>SLC5A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326932</externalid>
        <name>SLC2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58351</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402717</externalid>
        <name>SLC45A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328930</externalid>
        <name>SLC2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342425</externalid>
        <name>SLC2A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402824</externalid>
        <name>SLC5A10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6R4Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342490</externalid>
        <name>SLC5A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B749</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342440</externalid>
        <name>SLC2A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342377</externalid>
        <name>SLC2A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342524</externalid>
        <name>MFSD4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326918</externalid>
        <name>SLC5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6XUI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377929</externalid>
        <name>FGF8C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407496</externalid>
        <name>LOC538810</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407514</externalid>
        <name>SLC2A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342436</externalid>
        <name>SLC2A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328926</externalid>
        <name>SLC2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P27674</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342520</externalid>
        <name>SLC5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-189200</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-429593</externalid>
    <name>Inositol transporters</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-429593</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342453</externalid>
        <name>SLC2A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BML6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342497</externalid>
        <name>SLC5A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429607</externalid>
        <name>1D-chiro-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27372</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>426618</externalid>
        <name>myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17268</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-429593</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-425397</externalid>
    <name>Transport of vitamins, nucleosides, and related molecules</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-425397</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347131</externalid>
        <name>SLC35B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347117</externalid>
        <name>SLC35A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6YC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347124</externalid>
        <name>SLC35C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322700</externalid>
        <name>SLC25A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377253</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325214</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322706</externalid>
        <name>SLC25A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32007</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347104</externalid>
        <name>SLC35B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377329</externalid>
        <name>ARL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377267</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377261</externalid>
        <name>APOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377335</externalid>
        <name>ARL2BP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377271</externalid>
        <name>LCN9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329726</externalid>
        <name>SLC5A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347527</externalid>
        <name>SLC27A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318518</externalid>
        <name>SLC28A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318525</externalid>
        <name>SLC28A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N428</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377257</externalid>
        <name>LCN12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347051</externalid>
        <name>SLC29A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329722</externalid>
        <name>PDZD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347086</externalid>
        <name>ugt</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347065</externalid>
        <name>SLC33A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318504</externalid>
        <name>SLC28A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347108</externalid>
        <name>SLC35B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347531</externalid>
        <name>SLC27A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318493</externalid>
        <name>SLC29A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360841</externalid>
        <name>SLC25A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347058</externalid>
        <name>SLC29A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347535</externalid>
        <name>SLC27A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318489</externalid>
        <name>SLC29A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114783</externalid>
        <name>biotin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15956</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317526</externalid>
        <name>(R)-pantothenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38769</externalid>
        <name>icosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28822</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42379</externalid>
        <name>tetracosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30056</externalid>
        <name>cytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30629</externalid>
        <name>lipoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16494</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-83936</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-727802</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-804914</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-425397</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425407</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-83936</externalid>
    <name>Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-83936</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10377329</externalid>
        <name>ARL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347051</externalid>
        <name>SLC29A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318493</externalid>
        <name>SLC29A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377335</externalid>
        <name>ARL2BP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322700</externalid>
        <name>SLC25A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318518</externalid>
        <name>SLC28A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322706</externalid>
        <name>SLC25A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32007</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360841</externalid>
        <name>SLC25A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02722</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318525</externalid>
        <name>SLC28A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N428</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347058</externalid>
        <name>SLC29A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318504</externalid>
        <name>SLC28A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318489</externalid>
        <name>SLC29A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114798</externalid>
        <name>thymine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17821</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114934</externalid>
        <name>2'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17256</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29914</externalid>
        <name>uridine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16704</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114780</externalid>
        <name>uracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114937</externalid>
        <name>guanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30056</externalid>
        <name>cytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16040</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30213</externalid>
        <name>cytidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114936</externalid>
        <name>adenine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16708</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114812</externalid>
        <name>hypoxanthine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29760</externalid>
        <name>thymidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17748</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-83936</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425397</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-727802</externalid>
    <name>Transport of nucleotide sugars</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-727802</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347141</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347131</externalid>
        <name>SLC35B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347108</externalid>
        <name>SLC35B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347117</externalid>
        <name>SLC35A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6YC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347124</externalid>
        <name>SLC35C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347086</externalid>
        <name>ugt</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325214</externalid>
        <name>SLC35D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347104</externalid>
        <name>SLC35B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-727802</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425397</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-804914</externalid>
    <name>Transport of fatty acids</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-804914</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347531</externalid>
        <name>SLC27A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377267</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377261</externalid>
        <name>APOD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377271</externalid>
        <name>LCN9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347527</externalid>
        <name>SLC27A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377253</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347535</externalid>
        <name>SLC27A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377257</externalid>
        <name>LCN12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42379</externalid>
        <name>tetracosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28866</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163857</externalid>
        <name>lipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38769</externalid>
        <name>icosanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28822</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-804914</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-425397</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-445717</externalid>
    <name>Aquaporin-mediated transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-445717</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343096</externalid>
        <name>MYO5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343100</externalid>
        <name>RAB11FIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342971</externalid>
        <name>AQP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77750</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346428</externalid>
        <name>AQP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342980</externalid>
        <name>AQP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346416</externalid>
        <name>AQP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346422</externalid>
        <name>AQP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346404</externalid>
        <name>MIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P06624</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342950</externalid>
        <name>AQP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344017</externalid>
        <name>AQP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336221</externalid>
        <name>AVP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342961</externalid>
        <name>AQP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346410</externalid>
        <name>AQP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336225</externalid>
        <name>AVPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48044</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346434</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-432047</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-432040</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-432030</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-445717</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432047</externalid>
    <name>Passive transport by Aquaporins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-432047</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344017</externalid>
        <name>AQP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342961</externalid>
        <name>AQP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346410</externalid>
        <name>AQP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342971</externalid>
        <name>AQP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77750</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346416</externalid>
        <name>AQP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346428</externalid>
        <name>AQP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346422</externalid>
        <name>AQP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342980</externalid>
        <name>AQP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346404</externalid>
        <name>MIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P06624</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342950</externalid>
        <name>AQP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346434</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114776</externalid>
        <name>urea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432047</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445717</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432040</externalid>
    <name>Vasopressin regulates renal water homeostasis via Aquaporins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-432040</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343096</externalid>
        <name>MYO5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343100</externalid>
        <name>RAB11FIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342971</externalid>
        <name>AQP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77750</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344017</externalid>
        <name>AQP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336221</externalid>
        <name>AVP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342961</externalid>
        <name>AQP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336225</externalid>
        <name>AVPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48044</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432040</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445717</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432030</externalid>
    <name>Transport of glycerol from adipocytes to the liver by Aquaporins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-432030</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342980</externalid>
        <name>AQP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342950</externalid>
        <name>AQP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432030</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445717</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-917937</externalid>
    <name>Iron uptake and transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-917937</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326962</externalid>
        <name>HMOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348793</externalid>
        <name>CYBRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348830</externalid>
        <name>STEAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351516</externalid>
        <name>FBXL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348873</externalid>
        <name>MCOLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386834</externalid>
        <name>CAND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343284</externalid>
        <name>FTL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46415</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343498</externalid>
        <name>HEPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386815</externalid>
        <name>FTMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386712</externalid>
        <name>ACO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346235</externalid>
        <name>TF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316638</externalid>
        <name>ATP6AP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40682</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348822</externalid>
        <name>STEAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374651</externalid>
        <name>NEDD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316512</externalid>
        <name>ATP6V0A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348863</externalid>
        <name>FLVCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341390</externalid>
        <name>TFRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343502</externalid>
        <name>SLC40A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343358</externalid>
        <name>SLC11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326956</externalid>
        <name>HMOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386721</externalid>
        <name>IREB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343280</externalid>
        <name>FTH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46414</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386850</externalid>
        <name>HFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EEZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383007</externalid>
        <name>SLC22A17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386842</externalid>
        <name>TFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316520</externalid>
        <name>ATP6V0A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347778</externalid>
        <name>CP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N076</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330150</externalid>
        <name>SLC46A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377243</externalid>
        <name>LCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5691104</externalid>
        <name>iron(III) oxide-hydroxide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78619</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30479</externalid>
        <name>2,5-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29484</externalid>
        <name>copper atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28694</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157767</externalid>
        <name>electron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10545</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-917977</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-917937</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-917977</externalid>
    <name>Transferrin endocytosis and recycling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-917977</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346235</externalid>
        <name>TF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316638</externalid>
        <name>ATP6AP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40682</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348822</externalid>
        <name>STEAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348830</externalid>
        <name>STEAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316512</externalid>
        <name>ATP6V0A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348873</externalid>
        <name>MCOLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341390</externalid>
        <name>TFRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386850</externalid>
        <name>HFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EEZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386842</externalid>
        <name>TFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316520</externalid>
        <name>ATP6V0A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2168736</externalid>
        <name>heme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-917977</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-917937</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-983712</externalid>
    <name>Ion channel transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983712</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349307</externalid>
        <name>ATP11B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364553</externalid>
        <name>TRPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335858</externalid>
        <name>NEK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369406</externalid>
        <name>TTYH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349162</externalid>
        <name>FXYD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377616</externalid>
        <name>ATP13A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349335</externalid>
        <name>ATP8B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340556</externalid>
        <name>ATP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348873</externalid>
        <name>MCOLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349115</externalid>
        <name>ATP2C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368868</externalid>
        <name>ASIC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369463</externalid>
        <name>RYR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369449</externalid>
        <name>CASQ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349111</externalid>
        <name>ATP2C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P57709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371335</externalid>
        <name>TRPV6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340577</externalid>
        <name>ATP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349178</externalid>
        <name>FXYD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369007</externalid>
        <name>ANO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M082</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377620</externalid>
        <name>ATP13A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369339</externalid>
        <name>OSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369549</externalid>
        <name>SLC9B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368880</externalid>
        <name>ASIC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369022</externalid>
        <name>CLCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368987</externalid>
        <name>ANO10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368945</externalid>
        <name>SGK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369421</externalid>
        <name>BEST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369052</externalid>
        <name>NALCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369073</externalid>
        <name>CLCN5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369457</externalid>
        <name>RYR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349347</externalid>
        <name>ATP8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349331</externalid>
        <name>ATP9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371316</externalid>
        <name>TRPV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371280</externalid>
        <name>MCOLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414302</externalid>
        <name>ATP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371320</externalid>
        <name>TRPV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369473</externalid>
        <name>FKBP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316638</externalid>
        <name>ATP6AP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40682</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368862</externalid>
        <name>ASIC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349339</externalid>
        <name>ATP8B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349144</externalid>
        <name>ATP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349319</externalid>
        <name>ATP10D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369374</externalid>
        <name>CLCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNR5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369556</externalid>
        <name>SLC17A3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340560</externalid>
        <name>ATP2B2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN60</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316512</externalid>
        <name>ATP6V0A1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH43</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
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          </protein>
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      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10387033</externalid>
        <name>ATP13A2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10371296</externalid>
        <name>TRPC4AP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N232</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340564</externalid>
        <name>ATP2B3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS16</externalid>
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          </protein>
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      <gene>
        <externalid>10371312</externalid>
        <name>TRPM8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPC8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349263</externalid>
        <name>ATP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLX8</externalid>
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          </protein>
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      <gene>
        <externalid>10369568</externalid>
        <name>SLC9B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349343</externalid>
        <name>ATP10B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369069</externalid>
        <name>CLCN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4F894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349152</externalid>
        <name>ATP1B3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0C6</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10371292</externalid>
        <name>TRPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79100</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371324</externalid>
        <name>TRPV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M778</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369015</externalid>
        <name>ANO9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349126</externalid>
        <name>ATP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340581</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10368966</externalid>
        <name>LRRK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6C1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369443</externalid>
        <name>casq1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05JF3</externalid>
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          </protein>
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      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10349138</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8N5</externalid>
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          </protein>
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      <gene>
        <externalid>10368908</externalid>
        <name>SCNN1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY57</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10371284</externalid>
        <name>MCOLN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG0</externalid>
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          </protein>
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      <gene>
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        <name>TRPM4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNX9</externalid>
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          </protein>
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      <gene>
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        <name>BEST1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4I7</externalid>
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          </protein>
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    </genes>
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        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672372</externalid>
        <name>non-steroidal anti-inflammatory drug</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164164</externalid>
        <name>cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36916</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2730675</externalid>
        <name>nicotinic acid-adenine dinucleotide phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76072</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5252032</externalid>
        <name>divalent metal cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60240</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-936837</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2672351</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-983712</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-936837</externalid>
    <name>Ion transport by P-type ATPases</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-936837</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349307</externalid>
        <name>ATP11B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349158</externalid>
        <name>FXYD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349162</externalid>
        <name>FXYD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377616</externalid>
        <name>ATP13A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349335</externalid>
        <name>ATP8B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340556</externalid>
        <name>ATP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349295</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349115</externalid>
        <name>ATP2C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349111</externalid>
        <name>ATP2C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P57709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340577</externalid>
        <name>ATP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349178</externalid>
        <name>FXYD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349303</externalid>
        <name>ATP8B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M082</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377620</externalid>
        <name>ATP13A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349174</externalid>
        <name>FXYD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349148</externalid>
        <name>ATP1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349315</externalid>
        <name>ATP10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349347</externalid>
        <name>ATP8A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340585</externalid>
        <name>ATP2A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349331</externalid>
        <name>ATP9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414302</externalid>
        <name>ATP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387026</externalid>
        <name>ATP13A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349311</externalid>
        <name>ATP11C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349339</externalid>
        <name>ATP8B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349327</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349319</externalid>
        <name>ATP10D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349144</externalid>
        <name>ATP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349267</externalid>
        <name>ATP12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349170</externalid>
        <name>FXYD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340560</externalid>
        <name>ATP2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349299</externalid>
        <name>ATP8B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387033</externalid>
        <name>ATP13A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340564</externalid>
        <name>ATP2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349263</externalid>
        <name>ATP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349323</externalid>
        <name>ATP11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349134</externalid>
        <name>ATP1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342084</externalid>
        <name>PLN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349343</externalid>
        <name>ATP10B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349152</externalid>
        <name>ATP1B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349130</externalid>
        <name>ATP1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349126</externalid>
        <name>ATP1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340581</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340568</externalid>
        <name>ATP2B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3K0R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349138</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164164</externalid>
        <name>cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36916</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5252032</externalid>
        <name>divalent metal cation</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60240</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-936837</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983712</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2672351</externalid>
    <name>Stimuli-sensing channels</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2672351</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10364553</externalid>
        <name>TRPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368896</externalid>
        <name>SCNN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7U4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335858</externalid>
        <name>NEK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369406</externalid>
        <name>TTYH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391284</externalid>
        <name>STOM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369370</externalid>
        <name>CLCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371370</externalid>
        <name>TRPM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348873</externalid>
        <name>MCOLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369026</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368868</externalid>
        <name>ASIC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369463</externalid>
        <name>RYR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368983</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369449</externalid>
        <name>CASQ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369335</externalid>
        <name>CLCN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4PKH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369077</externalid>
        <name>CLCN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371335</externalid>
        <name>TRPV6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369007</externalid>
        <name>ANO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341859</externalid>
        <name>TRPC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369043</externalid>
        <name>TPCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N2G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371304</externalid>
        <name>TRPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369339</externalid>
        <name>OSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368880</externalid>
        <name>ASIC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369549</externalid>
        <name>SLC9B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369022</externalid>
        <name>CLCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369382</externalid>
        <name>CLCNKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369003</externalid>
        <name>ANO5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368987</externalid>
        <name>ANO10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368945</externalid>
        <name>SGK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369421</externalid>
        <name>BEST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369060</externalid>
        <name>UNC80</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369052</externalid>
        <name>NALCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368874</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371308</externalid>
        <name>TRPM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369073</externalid>
        <name>CLCN5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369457</externalid>
        <name>RYR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369397</externalid>
        <name>TTYH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371316</externalid>
        <name>TRPV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368995</externalid>
        <name>ANO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371280</externalid>
        <name>MCOLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369056</externalid>
        <name>UNC79</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0G4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369425</externalid>
        <name>BEST4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371320</externalid>
        <name>TRPV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400617</externalid>
        <name>STOML3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368862</externalid>
        <name>ASIC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369473</externalid>
        <name>FKBP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368941</externalid>
        <name>SGK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369039</externalid>
        <name>TPCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369374</externalid>
        <name>CLCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369556</externalid>
        <name>SLC17A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368900</externalid>
        <name>SCNN1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369011</externalid>
        <name>ANO8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368904</externalid>
        <name>SCNN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55270</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371296</externalid>
        <name>TRPC4AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N232</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368999</externalid>
        <name>ANO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371312</externalid>
        <name>TRPM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371331</externalid>
        <name>TRPV5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Y9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369485</externalid>
        <name>CLIC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>85453</externalid>
        <name>ASPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28056</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368991</externalid>
        <name>ANO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369568</externalid>
        <name>SLC9B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341855</externalid>
        <name>TRPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341688</externalid>
        <name>SRI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QQY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369030</externalid>
        <name>CLCA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369069</externalid>
        <name>CLCN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4F894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371292</externalid>
        <name>TRPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371324</externalid>
        <name>TRPV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M778</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371300</externalid>
        <name>TRPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369015</externalid>
        <name>ANO9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369393</externalid>
        <name>TTYH3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368951</externalid>
        <name>TSC22D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369378</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368966</externalid>
        <name>LRRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371288</externalid>
        <name>TRPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369443</externalid>
        <name>casq1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05JF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369417</externalid>
        <name>BEST2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9858797</externalid>
        <name>TRPV4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368908</externalid>
        <name>SCNN1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371284</externalid>
        <name>MCOLN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371366</externalid>
        <name>TRPM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNX9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368889</externalid>
        <name>ASIC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369413</externalid>
        <name>BEST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114827</externalid>
        <name>7,9-dihydro-1H-purine-2,6,8(3H)-trione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17775</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2730675</externalid>
        <name>nicotinic acid-adenine dinucleotide phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76072</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2672372</externalid>
        <name>non-steroidal anti-inflammatory drug</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35475</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3295583</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2672351</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983712</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3295583</externalid>
    <name>TRP channels</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3295583</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10371320</externalid>
        <name>TRPV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA32</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364553</externalid>
        <name>TRPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371370</externalid>
        <name>TRPM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371353</externalid>
        <name>MLKL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341851</externalid>
        <name>TRPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348873</externalid>
        <name>MCOLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY82</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371296</externalid>
        <name>TRPC4AP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N232</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371312</externalid>
        <name>TRPM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPC8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371331</externalid>
        <name>TRPV5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Y9</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAN3</externalid>
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          </protein>
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      <gene>
        <externalid>10318226</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
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          </protein>
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      <gene>
        <externalid>10341859</externalid>
        <name>TRPC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MYW0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRPM2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341855</externalid>
        <name>TRPC7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTG6</externalid>
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          </protein>
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      <gene>
        <externalid>10371292</externalid>
        <name>TRPC4</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
        <externalid>10371324</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371300</externalid>
        <name>TRPC5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTE6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371308</externalid>
        <name>TRPM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPF0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371316</externalid>
        <name>TRPV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
        <externalid>10371288</externalid>
        <name>TRPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371280</externalid>
        <name>MCOLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9858797</externalid>
        <name>TRPV4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10371284</externalid>
        <name>MCOLN3</name>
        <entity>
          <protein>
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              <externalid>E1BDG0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10371366</externalid>
        <name>TRPM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNX9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3295583</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2672351</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1480926</externalid>
    <name>O2/CO2 exchange in erythrocytes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1480926</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10343735</externalid>
        <name>RHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346160</externalid>
        <name>CYB5R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395377</externalid>
        <name>CYB5R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354300</externalid>
        <name>CA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95323</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356605</externalid>
        <name>CA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354357</externalid>
        <name>HBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02070</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341626</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QPG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356611</externalid>
        <name>CA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354351</externalid>
        <name>HBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395381</externalid>
        <name>CYB5RL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395373</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N310</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1237044</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1247673</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1480926</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1237044</externalid>
    <name>Erythrocytes take up carbon dioxide and release oxygen</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1237044</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343735</externalid>
        <name>RHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346160</externalid>
        <name>CYB5R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395377</externalid>
        <name>CYB5R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354300</externalid>
        <name>CA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95323</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356605</externalid>
        <name>CA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354357</externalid>
        <name>HBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02070</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341626</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QPG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356611</externalid>
        <name>CA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354351</externalid>
        <name>HBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395381</externalid>
        <name>CYB5RL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIS5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395373</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N310</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1237044</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1480926</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1247673</externalid>
    <name>Erythrocytes take up oxygen and release carbon dioxide</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1247673</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343735</externalid>
        <name>RHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354300</externalid>
        <name>CA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95323</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356605</externalid>
        <name>CA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354357</externalid>
        <name>HBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02070</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356611</externalid>
        <name>CA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354351</externalid>
        <name>HBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341626</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QPG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342941</externalid>
        <name>AQP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114817</externalid>
        <name>hydrogencarbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1247673</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1480926</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5223345</externalid>
    <name>Miscellaneous transport and binding events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>NIPAL1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BD04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377896</externalid>
        <name>NIPA2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377921</externalid>
        <name>MRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330467</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403462</externalid>
        <name>SLC66A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377950</externalid>
        <name>MAGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N598</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377957</externalid>
        <name>CSN1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02662</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404857</externalid>
        <name>LRRC8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377936</externalid>
        <name>TUSC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377892</externalid>
        <name>NIPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N136</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377648</externalid>
        <name>PIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377054</externalid>
        <name>DMTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377041</externalid>
        <name>ANKH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377048</externalid>
        <name>ADD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXA4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343728</externalid>
        <name>RHCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0T1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377904</externalid>
        <name>NIPAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHG8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377062</externalid>
        <name>ADD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDE1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343735</externalid>
        <name>RHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377908</externalid>
        <name>NIPAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404869</externalid>
        <name>LRRC8D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377973</externalid>
        <name>CTNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377912</externalid>
        <name>NIPAL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377640</externalid>
        <name>AZGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DK44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377962</externalid>
        <name>CSN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343742</externalid>
        <name>RHBG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95M77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404853</externalid>
        <name>LLRC8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404875</externalid>
        <name>LRRC8E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PRJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404863</externalid>
        <name>LRRC8C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5340139</externalid>
        <name>calcium phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30607</externalid>
        <name>iodide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16382</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9960118</externalid>
        <name>L-cystine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35491</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925939</externalid>
        <name>L-histidine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57595</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-444411</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5223345</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-444411</externalid>
    <name>Rhesus glycoproteins mediate ammonium transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-444411</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343735</externalid>
        <name>RHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343742</externalid>
        <name>RHBG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95M77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343728</externalid>
        <name>RHCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-444411</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5223345</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8949215</externalid>
    <name>Mitochondrial calcium ion transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8949215</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10405440</externalid>
        <name>PHB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405476</externalid>
        <name>PARL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405434</externalid>
        <name>SPG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E2Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405456</externalid>
        <name>PMPCA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405484</externalid>
        <name>YME1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405405</externalid>
        <name>MICU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR44</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405401</externalid>
        <name>SMDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2M2S2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405409</externalid>
        <name>MICU3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405397</externalid>
        <name>MICU1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405389</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405428</externalid>
        <name>AFG3L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341717</externalid>
        <name>SLC8B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383188</externalid>
        <name>PHB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T165</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405480</externalid>
        <name>STOML2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405460</externalid>
        <name>PMPCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B941</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405393</externalid>
        <name>MCUB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405424</externalid>
        <name>MAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8949664</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8949215</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8949664</externalid>
    <name>Processing of SMDT1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8949664</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>PHB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405476</externalid>
        <name>PARL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405434</externalid>
        <name>SPG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E2Z6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405456</externalid>
        <name>PMPCA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405405</externalid>
        <name>MICU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405484</externalid>
        <name>YME1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405401</externalid>
        <name>SMDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2M2S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405409</externalid>
        <name>MICU3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405397</externalid>
        <name>MICU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405389</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405428</externalid>
        <name>AFG3L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383188</externalid>
        <name>PHB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T165</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405480</externalid>
        <name>STOML2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405460</externalid>
        <name>PMPCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B941</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405393</externalid>
        <name>MCUB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405424</externalid>
        <name>MAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8949664</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8949215</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174824</externalid>
    <name>Plasma lipoprotein assembly, remodeling, and clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174824</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10334228</externalid>
        <name>PLTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333817</externalid>
        <name>LCAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW4</externalid>
            </xref>
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        </entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>F1MCT1</externalid>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>O18824</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>CES3</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>cholesteryl ester</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>coenzyme A(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <externalid>57379</externalid>
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      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-8963898</externalid>
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        <externalid>R-HSA-174824</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-382551</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963898</externalid>
    <name>Plasma lipoprotein assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963898</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325506</externalid>
        <name>MTTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333727</externalid>
        <name>ABCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384062</externalid>
        <name>ZDHHC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325432</externalid>
        <name>SAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333841</externalid>
        <name>BMP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8963888</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8866423</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963896</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8963898</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174824</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963888</externalid>
    <name>Chylomicron assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963888</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325506</externalid>
        <name>MTTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325432</externalid>
        <name>SAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963888</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8866423</externalid>
    <name>VLDL assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8866423</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325506</externalid>
        <name>MTTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8866423</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963896</externalid>
    <name>HDL assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963896</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10384062</externalid>
        <name>ZDHHC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333727</externalid>
        <name>ABCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333841</externalid>
        <name>BMP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963896</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963899</externalid>
    <name>Plasma lipoprotein remodeling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963899</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326676</externalid>
        <name>PCSK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325506</externalid>
        <name>MTTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334228</externalid>
        <name>PLTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333817</externalid>
        <name>LCAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325534</externalid>
        <name>APOA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389305</externalid>
        <name>LMF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326672</externalid>
        <name>PCSK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407448</externalid>
        <name>LIPG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389193</externalid>
        <name>ANGPTL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325459</externalid>
        <name>LIPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325523</externalid>
        <name>LPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11151</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389183</externalid>
        <name>ANGPTL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389187</externalid>
        <name>ANGPTL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389301</externalid>
        <name>LMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LU66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325519</externalid>
        <name>GPIHBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8963889</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963901</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964041</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964058</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8963899</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174824</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963889</externalid>
    <name>Assembly of active LPL and LIPC lipase complexes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963889</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326676</externalid>
        <name>PCSK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325523</externalid>
        <name>LPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11151</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389187</externalid>
        <name>ANGPTL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389301</externalid>
        <name>LMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LU66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389193</externalid>
        <name>ANGPTL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325519</externalid>
        <name>GPIHBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389305</externalid>
        <name>LMF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326672</externalid>
        <name>PCSK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325459</externalid>
        <name>LIPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389183</externalid>
        <name>ANGPTL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963889</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963899</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8963901</externalid>
    <name>Chylomicron remodeling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8963901</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325523</externalid>
        <name>LPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11151</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325410</externalid>
        <name>APOA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325534</externalid>
        <name>APOA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325519</externalid>
        <name>GPIHBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8963901</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963899</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964041</externalid>
    <name>LDL remodeling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964041</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325506</externalid>
        <name>MTTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964041</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963899</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964058</externalid>
    <name>HDL remodeling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964058</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325472</externalid>
        <name>APOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334228</externalid>
        <name>PLTP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333817</externalid>
        <name>LCAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407448</externalid>
        <name>LIPG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325468</externalid>
        <name>APOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964058</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8963899</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964043</externalid>
    <name>Plasma lipoprotein clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964043</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335830</externalid>
        <name>NR1H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332580</externalid>
        <name>CUBN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334264</externalid>
        <name>SCARB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18824</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402918</externalid>
        <name>SOAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N277</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325459</externalid>
        <name>LIPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401043</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402914</externalid>
        <name>SOAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324660</externalid>
        <name>LDLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01131</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392878</externalid>
        <name>NPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79345</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403768</externalid>
        <name>CES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399815</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335950</externalid>
        <name>NR1H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397490</externalid>
        <name>NCEH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351712</externalid>
        <name>MYLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333852</externalid>
        <name>AMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402870</externalid>
        <name>NPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400327</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8964026</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964038</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964011</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8866427</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8964043</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174824</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964026</externalid>
    <name>Chylomicron clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964026</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324660</externalid>
        <name>LDLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01131</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325459</externalid>
        <name>LIPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964026</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964043</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964038</externalid>
    <name>LDL clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964038</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324660</externalid>
        <name>LDLR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01131</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392878</externalid>
        <name>NPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79345</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403768</externalid>
        <name>CES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324698</externalid>
        <name>LDLRAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397490</externalid>
        <name>NCEH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402918</externalid>
        <name>SOAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N277</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402870</externalid>
        <name>NPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401043</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402914</externalid>
        <name>SOAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9914144</externalid>
        <name>acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964038</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964043</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964011</externalid>
    <name>HDL clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964011</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332580</externalid>
        <name>CUBN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334264</externalid>
        <name>SCARB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18824</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333852</externalid>
        <name>AMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400327</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964011</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964043</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8866427</externalid>
    <name>VLDLR internalisation and degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8866427</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335830</externalid>
        <name>NR1H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399815</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335950</externalid>
        <name>NR1H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351712</externalid>
        <name>MYLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8866427</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964043</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8981607</externalid>
    <name>Intracellular oxygen transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8981607</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10407525</externalid>
        <name>MB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02192</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377983</externalid>
        <name>CYGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407535</externalid>
        <name>NGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6WZ19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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    </linkedsystems>
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  <biosystem>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>OR1E2B</name>
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          </protein>
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      </gene>
      <gene>
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        <name>LPL</name>
        <entity>
          <protein>
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              <externalid>P11151</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSD17B6</name>
        <entity>
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              <externalid>F1MG20</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LRP10</name>
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              <externalid>A6QPB1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10337594</externalid>
        <name>TAS1R3</name>
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              <externalid>A0A3Q1NND8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CLPS</name>
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              <externalid>A0JNQ7</externalid>
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          </protein>
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      <gene>
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        <name>GPC5</name>
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          </protein>
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      </gene>
      <gene>
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        <name>TAS2R7</name>
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      </gene>
      <gene>
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        <name>T2R10C</name>
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              <externalid>Q2ABC0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RGS9</name>
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          </protein>
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      </gene>
      <gene>
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        <name>OR51L1C</name>
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          </protein>
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      <gene>
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        <name>OR2T55</name>
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          </protein>
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      <gene>
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        <name>OR11H4</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DHRS3</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>OR9G1</name>
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          <protein>
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              <externalid>G5E6E2</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1MCE6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>OR8B3</name>
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              <externalid>G5E5K6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2C1</name>
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              <externalid>F1N5X4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBP3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MLW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Y4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BCO2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Z9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389658</externalid>
        <name>CYP4V2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Z7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316765</externalid>
        <name>RLBP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10123</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SDR9C7</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A4IFM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2T1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MPJ0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>OR10J5</name>
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              <externalid>E1B9X6</externalid>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR94</externalid>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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        <name>TAS2R3</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GNB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413684</externalid>
        <name>OR10G9G</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN95</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413952</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDY7</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10341059</externalid>
        <name>OPN1SW</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P51490</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377320</externalid>
        <name>APOM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413902</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDQ4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10413744</externalid>
        <name>OR1A1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI27</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316828</externalid>
        <name>PPEF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367675</externalid>
        <name>RBP4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K122</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327776</externalid>
        <name>PNLIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413944</externalid>
        <name>OR2W3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNP4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413676</externalid>
        <name>OR10A6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413692</externalid>
        <name>OR10G9E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413898</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N299</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCN6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337406</externalid>
        <name>TAS2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413702</externalid>
        <name>OR10H1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR48</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366208</externalid>
        <name>LRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368908</externalid>
        <name>SCNN1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY57</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413810</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM11</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
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          </protein>
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    </genes>
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        <externalid>9737196</externalid>
        <name>geranyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316670</externalid>
        <name>flamenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729054</externalid>
        <name>Methylthiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737153</externalid>
        <name>octane-1-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737295</externalid>
        <name>pentyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753706</externalid>
        <name>7-methyloctan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42265</externalid>
        <name>isovaleric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32235</externalid>
        <name>(-)-carvone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15400</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729056</externalid>
        <name>acesulfame</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39251</externalid>
        <name>cycloheximide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729072</externalid>
        <name>divinyl sulfoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14217</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46601</externalid>
        <name>eugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737293</externalid>
        <name>TMT</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>181287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48427</externalid>
        <name>(+)-carvone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15399</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30933</externalid>
        <name>(E)-cinnamaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729062</externalid>
        <name>N,N'-diphenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46603</externalid>
        <name>O-methyleugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4918</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737367</externalid>
        <name>sotolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67890</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1423440</externalid>
        <name>beta-ionone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737194</externalid>
        <name>Dicyclohexyl disulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>166589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737182</externalid>
        <name>Bis(2-furanylmethyl) disulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>171681</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39731</externalid>
        <name>diphenidol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729055</externalid>
        <name>denatonium benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46633</externalid>
        <name>isoeugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753718</externalid>
        <name>1,2,3-trimethylbenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737266</externalid>
        <name>Androsta-4,16-dien-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>92979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753715</externalid>
        <name>Cedrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>167345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34651</externalid>
        <name>11-cis-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31713</externalid>
        <name>benzoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735723</externalid>
        <name>3-Phenylpropyl propanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>179906</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35411</externalid>
        <name>linalool</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729073</externalid>
        <name>Ethylenethiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737307</externalid>
        <name>Homodihydrojasmone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>171895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729065</externalid>
        <name>N-acetylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737308</externalid>
        <name>Ethylene brassylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>168721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737259</externalid>
        <name>butyl anthranilate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86192</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729071</externalid>
        <name>flufenamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753728</externalid>
        <name>lilial</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>228987</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422040</externalid>
        <name>octanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737206</externalid>
        <name>2-decenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61727</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9712197</externalid>
        <name>p-methoxybenzaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32701</externalid>
        <name>thioglycolic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729061</externalid>
        <name>N-phenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39619</externalid>
        <name>chlorhexidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735716</externalid>
        <name>5alpha-androst-16-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37894</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31841</externalid>
        <name>guaiacol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30677</externalid>
        <name>vanillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31829</externalid>
        <name>farnesol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45461</externalid>
        <name>alpha-pinene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30437</externalid>
        <name>1,10-phenanthroline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31955</externalid>
        <name>hexanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45443</externalid>
        <name>nerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729063</externalid>
        <name>dapsone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729069</externalid>
        <name>4,5-dihydrocortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729066</externalid>
        <name>N-methylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729070</externalid>
        <name>N-ethylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30090</externalid>
        <name>(-)-menthol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729058</externalid>
        <name>dimethylthioformamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753703</externalid>
        <name>helional</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9712172</externalid>
        <name>lyral</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737312</externalid>
        <name>ethyl vanillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729067</externalid>
        <name>p-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737160</externalid>
        <name>2-Methoxy-4-methylphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>89886</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45335</externalid>
        <name>benzamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39069</externalid>
        <name>epsilon-caprolactam</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40903</externalid>
        <name>6-propyl-2-thiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31839</externalid>
        <name>geraniol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33005</externalid>
        <name>dodecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729068</externalid>
        <name>carisoprodol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42712</externalid>
        <name>(Z)-hex-3-en-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28857</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753747</externalid>
        <name>heptanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737165</externalid>
        <name>2-ethylfenchol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>106997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38745</externalid>
        <name>quinoline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737309</externalid>
        <name>2-Propenyl phenylacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>168585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729064</externalid>
        <name>orphenadrine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737368</externalid>
        <name>(+)-menthol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753746</externalid>
        <name>cyclohexyl 2-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>101330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39491</externalid>
        <name>azathioprine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316236</externalid>
        <name>benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737205</externalid>
        <name>Acetyleugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34522</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737286</externalid>
        <name>undecanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46202</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729059</externalid>
        <name>cromoglycate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-381753</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187338</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9717189</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9709957</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381753</externalid>
    <name>Olfactory Signaling Pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381753</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10413752</externalid>
        <name>OR1D3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413918</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1A7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413698</externalid>
        <name>OR10H1I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413936</externalid>
        <name>OR8U9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413882</externalid>
        <name>OR51D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413784</externalid>
        <name>OR1N2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413724</externalid>
        <name>OR11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M979</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413906</externalid>
        <name>OR5K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413948</externalid>
        <name>OR10S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413844</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MV46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413910</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413848</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413762</externalid>
        <name>OR1E2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413792</externalid>
        <name>OR2AT2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3A7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413852</externalid>
        <name>OR2M16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCE3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413732</externalid>
        <name>OR11H6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413814</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413894</externalid>
        <name>OR51L1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW45</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413964</externalid>
        <name>OR2T55</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413720</externalid>
        <name>OR10X1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413728</externalid>
        <name>OR11H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413798</externalid>
        <name>OR2B11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413710</externalid>
        <name>OR10H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0MQ71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR51E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413758</externalid>
        <name>OR1E1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYP0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413940</externalid>
        <name>OR9G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6E2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413886</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413926</externalid>
        <name>OR8B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5K6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413802</externalid>
        <name>OR2C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5X4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10413922</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413874</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B829</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2T1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPJ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR10J5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9X6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MR94</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR10G9G</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2L13</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BLN0</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MDY7</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>OR14J1</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1M6S7</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDQ4</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413806</externalid>
        <name>OR2F2B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N1U9</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>GNAL</name>
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              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10413822</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BF26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR10G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413866</externalid>
        <name>OR13C11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW35</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR1D3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B865</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413826</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413774</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2W3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413676</externalid>
        <name>OR10A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAL0</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10413788</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413692</externalid>
        <name>OR10G9E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2K0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N299</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413878</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413778</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413770</externalid>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR10H1G</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR6F1</name>
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          <protein>
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              <externalid>F1MJ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413810</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OR2T29</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>9737194</externalid>
        <name>Dicyclohexyl disulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>166589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737196</externalid>
        <name>geranyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5331</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753728</externalid>
        <name>lilial</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>228987</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753703</externalid>
        <name>helional</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64805</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422040</externalid>
        <name>octanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9712172</externalid>
        <name>lyral</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737182</externalid>
        <name>Bis(2-furanylmethyl) disulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>171681</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737153</externalid>
        <name>octane-1-thiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737206</externalid>
        <name>2-decenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61727</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9712197</externalid>
        <name>p-methoxybenzaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737295</externalid>
        <name>pentyl acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46633</externalid>
        <name>isoeugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737312</externalid>
        <name>ethyl vanillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753718</externalid>
        <name>1,2,3-trimethylbenzene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32701</externalid>
        <name>thioglycolic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30065</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737266</externalid>
        <name>Androsta-4,16-dien-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>92979</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753715</externalid>
        <name>Cedrene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>167345</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737160</externalid>
        <name>2-Methoxy-4-methylphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>89886</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753706</externalid>
        <name>7-methyloctan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188348</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735716</externalid>
        <name>5alpha-androst-16-en-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37894</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42265</externalid>
        <name>isovaleric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32235</externalid>
        <name>(-)-carvone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15400</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31839</externalid>
        <name>geraniol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31841</externalid>
        <name>guaiacol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33005</externalid>
        <name>dodecan-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28878</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30677</externalid>
        <name>vanillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31829</externalid>
        <name>farnesol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30431</externalid>
        <name>phenylacetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42712</externalid>
        <name>(Z)-hex-3-en-1-ol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28857</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753747</externalid>
        <name>heptanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737165</externalid>
        <name>2-ethylfenchol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>106997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38745</externalid>
        <name>quinoline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17362</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45461</externalid>
        <name>alpha-pinene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737309</externalid>
        <name>2-Propenyl phenylacetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>168585</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735723</externalid>
        <name>3-Phenylpropyl propanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>179906</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35411</externalid>
        <name>linalool</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17580</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31955</externalid>
        <name>hexanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45443</externalid>
        <name>nerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737368</externalid>
        <name>(+)-menthol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737307</externalid>
        <name>Homodihydrojasmone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>171895</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46601</externalid>
        <name>eugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4917</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753746</externalid>
        <name>cyclohexyl 2-hydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>101330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737293</externalid>
        <name>TMT</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>181287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737308</externalid>
        <name>Ethylene brassylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>168721</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>48427</externalid>
        <name>(+)-carvone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15399</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737205</externalid>
        <name>Acetyleugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34522</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30933</externalid>
        <name>(E)-cinnamaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16731</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737259</externalid>
        <name>butyl anthranilate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86192</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737286</externalid>
        <name>undecanal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46202</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30090</externalid>
        <name>(-)-menthol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>46603</externalid>
        <name>O-methyleugenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4918</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737367</externalid>
        <name>sotolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67890</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381753</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9709957</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2187338</externalid>
    <name>Visual phototransduction</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2187338</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RCVRN</name>
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              <externalid>P21457</externalid>
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              <externalid>F1MNC0</externalid>
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              <externalid>P46065</externalid>
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      <gene>
        <externalid>9767349</externalid>
        <name>ABCA4</name>
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              <externalid>F1MWM0</externalid>
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      <gene>
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        <name>GRK7</name>
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              <externalid>F1MH44</externalid>
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              <externalid>F1N3Q7</externalid>
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              <externalid>P81644</externalid>
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              <externalid>Q08DZ5</externalid>
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              <externalid>Q8MJG0</externalid>
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              <externalid>P02698</externalid>
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              <externalid>A7MBG1</externalid>
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              <externalid>P49355</externalid>
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              <externalid>E1BKJ2</externalid>
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              <externalid>A0A3Q1MGM8</externalid>
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        <name>SDC4</name>
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      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666974</externalid>
        <name>heparan sulfate proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24499</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5164384</externalid>
        <name>10'-apo-beta-carotenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34651</externalid>
        <name>11-cis-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32717</externalid>
        <name>beta-carotene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975634</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2453902</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187335</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2514856</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2187338</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9709957</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2453902</externalid>
    <name>The canonical retinoid cycle in rods (twilight vision)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2453902</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368002</externalid>
        <name>HSD17B6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367681</externalid>
        <name>TTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46375</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367982</externalid>
        <name>STRA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367998</externalid>
        <name>RDH16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316751</externalid>
        <name>LOC101906939</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LU75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367967</externalid>
        <name>RPE65</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9767349</externalid>
        <name>ABCA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368019</externalid>
        <name>RBP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367675</externalid>
        <name>RBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389658</externalid>
        <name>CYP4V2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316765</externalid>
        <name>RLBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10123</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368010</externalid>
        <name>DHRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350845</externalid>
        <name>LRAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367973</externalid>
        <name>MYO7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LG56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368006</externalid>
        <name>SDR9C7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367994</externalid>
        <name>RDH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27979</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316773</externalid>
        <name>RDH10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316755</externalid>
        <name>RBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316777</externalid>
        <name>RDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368085</externalid>
        <name>RDH12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9907887</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77015</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534401</externalid>
        <name>all-trans-retinyl linoleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33427</externalid>
        <name>all-trans-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534419</externalid>
        <name>all-trans-retinyl stearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70761</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859062</externalid>
        <name>linoleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32386</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2534425</externalid>
        <name>all-trans-retinyl oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70760</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859064</externalid>
        <name>palmitoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>45021</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859067</externalid>
        <name>stearoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26753</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2859063</externalid>
        <name>oleoyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25667</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2453902</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187338</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2187335</externalid>
    <name>The retinoid cycle in cones (daylight vision)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2187335</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368137</externalid>
        <name>DHRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N334</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368124</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368019</externalid>
        <name>RBP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341055</externalid>
        <name>OPN1LW</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BGI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316765</externalid>
        <name>RLBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10123</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341059</externalid>
        <name>OPN1SW</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P51490</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34651</externalid>
        <name>11-cis-retinyl palmitate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16254</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2187335</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187338</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2514856</externalid>
    <name>The phototransduction cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2514856</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74547</externalid>
        <name>SAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08168</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74501</externalid>
        <name>RCVRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316786</externalid>
        <name>GUCY2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74040</externalid>
        <name>GNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04695</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368818</externalid>
        <name>GRK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316797</externalid>
        <name>GUCA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46065</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368573</externalid>
        <name>METAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368579</externalid>
        <name>METAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316803</externalid>
        <name>GUCA1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74497</externalid>
        <name>GRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28327</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316258</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74037</externalid>
        <name>PDE6G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330569</externalid>
        <name>FNTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N081</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244601</externalid>
        <name>RGS9BP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8MJG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316828</externalid>
        <name>PPEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368548</externalid>
        <name>FNTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49355</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368814</externalid>
        <name>GRK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316790</externalid>
        <name>GUCY2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321153</externalid>
        <name>NMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368842</externalid>
        <name>RGS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368562</externalid>
        <name>NMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389651</externalid>
        <name>LOC786620</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316254</externalid>
        <name>CNGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2485179</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2514859</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2514856</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2187338</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2485179</externalid>
    <name>Activation of the phototransduction cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2485179</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316258</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74037</externalid>
        <name>PDE6G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74040</externalid>
        <name>GNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04695</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316254</externalid>
        <name>CNGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2485179</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2514856</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2514859</externalid>
    <name>Inactivation, recovery and regulation of the phototransduction cascade</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74547</externalid>
        <name>SAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08168</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74501</externalid>
        <name>RCVRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316786</externalid>
        <name>GUCY2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74040</externalid>
        <name>GNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04695</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368818</externalid>
        <name>GRK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316797</externalid>
        <name>GUCA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46065</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316803</externalid>
        <name>GUCA1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368573</externalid>
        <name>METAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368579</externalid>
        <name>METAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74497</externalid>
        <name>GRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28327</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316258</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE6G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04972</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FNTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N081</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244601</externalid>
        <name>RGS9BP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8MJG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316828</externalid>
        <name>PPEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368548</externalid>
        <name>FNTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49355</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368814</externalid>
        <name>GRK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316790</externalid>
        <name>GUCY2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321153</externalid>
        <name>NMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368562</externalid>
        <name>NMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389651</externalid>
        <name>LOC786620</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316254</externalid>
        <name>CNGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29686</externalid>
        <name>cobalt atom</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9910892</externalid>
        <name>myristoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57385</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2514859</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2514856</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9717189</externalid>
    <name>Sensory perception of taste</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9717189</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337590</externalid>
        <name>TAS1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368896</externalid>
        <name>SCNN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7U4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368900</externalid>
        <name>SCNN1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337420</externalid>
        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337462</externalid>
        <name>TAS2R39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337492</externalid>
        <name>TAS2R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368904</externalid>
        <name>SCNN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55270</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337458</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337440</externalid>
        <name>TAS2R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337414</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337470</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337602</externalid>
        <name>TAS1R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337424</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337594</externalid>
        <name>TAS1R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NND8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337432</externalid>
        <name>TAS2R46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337488</externalid>
        <name>TAS2R7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337410</externalid>
        <name>T2R10C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337406</externalid>
        <name>TAS2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337466</externalid>
        <name>TAS2R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368908</externalid>
        <name>SCNN1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337428</externalid>
        <name>LOC782957</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9729058</externalid>
        <name>dimethylthioformamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316670</externalid>
        <name>flamenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729054</externalid>
        <name>Methylthiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39731</externalid>
        <name>diphenidol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729055</externalid>
        <name>denatonium benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729067</externalid>
        <name>p-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45335</externalid>
        <name>benzamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39069</externalid>
        <name>epsilon-caprolactam</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729061</externalid>
        <name>N-phenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40903</externalid>
        <name>6-propyl-2-thiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39619</externalid>
        <name>chlorhexidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31713</externalid>
        <name>benzoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729068</externalid>
        <name>carisoprodol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729064</externalid>
        <name>orphenadrine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729056</externalid>
        <name>acesulfame</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30437</externalid>
        <name>1,10-phenanthroline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39251</externalid>
        <name>cycloheximide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729063</externalid>
        <name>dapsone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729073</externalid>
        <name>Ethylenethiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729072</externalid>
        <name>divinyl sulfoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14217</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729069</externalid>
        <name>4,5-dihydrocortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39491</externalid>
        <name>azathioprine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729066</externalid>
        <name>N-methylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729065</externalid>
        <name>N-acetylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316236</externalid>
        <name>benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729070</externalid>
        <name>N-ethylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729062</externalid>
        <name>N,N'-diphenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729071</externalid>
        <name>flufenamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729059</externalid>
        <name>cromoglycate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9717207</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9730628</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9717189</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9709957</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9717207</externalid>
    <name>Sensory perception of sweet, bitter, and umami (glutamate) taste</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9717207</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337470</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337602</externalid>
        <name>TAS1R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337590</externalid>
        <name>TAS1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337424</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337594</externalid>
        <name>TAS1R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NND8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337432</externalid>
        <name>TAS2R46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337488</externalid>
        <name>TAS2R7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337420</externalid>
        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337410</externalid>
        <name>T2R10C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337406</externalid>
        <name>TAS2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337462</externalid>
        <name>TAS2R39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337492</externalid>
        <name>TAS2R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337466</externalid>
        <name>TAS2R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337458</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337440</externalid>
        <name>TAS2R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337414</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337428</externalid>
        <name>LOC782957</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9729058</externalid>
        <name>dimethylthioformamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114906</externalid>
        <name>paracetamol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46195</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316670</externalid>
        <name>flamenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136806</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729054</externalid>
        <name>Methylthiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39731</externalid>
        <name>diphenidol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729055</externalid>
        <name>denatonium benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>19518</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729067</externalid>
        <name>p-methoxyphenol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69441</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40179</externalid>
        <name>methimazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50673</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45335</externalid>
        <name>benzamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39069</externalid>
        <name>epsilon-caprolactam</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729061</externalid>
        <name>N-phenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46261</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40903</externalid>
        <name>6-propyl-2-thiouracil</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8502</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39619</externalid>
        <name>chlorhexidine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31713</externalid>
        <name>benzoin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729068</externalid>
        <name>carisoprodol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3419</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729064</externalid>
        <name>orphenadrine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729056</externalid>
        <name>acesulfame</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30437</externalid>
        <name>1,10-phenanthroline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44975</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39251</externalid>
        <name>cycloheximide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27641</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30687</externalid>
        <name>cortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729063</externalid>
        <name>dapsone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4325</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729073</externalid>
        <name>Ethylenethiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729072</externalid>
        <name>divinyl sulfoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>14217</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729069</externalid>
        <name>4,5-dihydrocortisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23736</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39491</externalid>
        <name>azathioprine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729066</externalid>
        <name>N-methylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943587</externalid>
        <name>L-aspartate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729065</externalid>
        <name>N-acetylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188350</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316236</externalid>
        <name>benzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16150</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729070</externalid>
        <name>N-ethylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>188349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729062</externalid>
        <name>N,N'-diphenylthiourea</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>138412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729071</externalid>
        <name>flufenamic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42638</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729059</externalid>
        <name>cromoglycate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59039</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9717207</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9717189</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9730628</externalid>
    <name>Sensory perception of salty taste</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9730628</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368900</externalid>
        <name>SCNN1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368904</externalid>
        <name>SCNN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55270</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368896</externalid>
        <name>SCNN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7U4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368908</externalid>
        <name>SCNN1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9730628</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9717189</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-162582</externalid>
    <name>Signal Transduction</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-162582</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336207</externalid>
        <name>GPHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363970</externalid>
        <name>CYFIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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      <gene>
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        <name>UTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
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      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
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      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
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      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9632066</externalid>
        <name>estetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142773</externalid>
        </xref>
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      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
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      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
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      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5362558</externalid>
        <name>9-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296453</externalid>
        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024327</externalid>
        <name>24(S),25-epoxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792597</externalid>
        <name>heparan sulfate alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024379</externalid>
        <name>(22R)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114736</externalid>
        <name>phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36981</externalid>
        <name>estriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
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      <linkedsystem>
        <externalid>R-BTA-9006936</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157118</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKACA</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338476</externalid>
        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393865</externalid>
        <name>MST1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316649</externalid>
        <name>CTSD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328325</externalid>
        <name>FLT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337998</externalid>
        <name>STAT5B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T878</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF23</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328359</externalid>
        <name>VEGFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XS49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366690</externalid>
        <name>ELMO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VAV2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326050</externalid>
        <name>EPGN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338277</externalid>
        <name>PDGFC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792597</externalid>
        <name>heparan sulfate alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-177929</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190236</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166520</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74752</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-186797</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194138</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1433557</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1227986</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236394</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2404192</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8852405</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201556</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9006934</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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    <name>Signaling by EGFR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-177929</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
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              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326195</externalid>
        <name>FAM83D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326072</externalid>
        <name>AAMP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326375</externalid>
        <name>SH3GL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326149</externalid>
        <name>PAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326381</externalid>
        <name>SH3GL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-179812</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177929</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-180336</externalid>
    <name>SHC1 events in EGFR signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-180336</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326042</externalid>
        <name>TGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326046</externalid>
        <name>AREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326050</externalid>
        <name>EPGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-180336</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177929</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-180292</externalid>
    <name>GAB1 signalosome</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-180292</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326149</externalid>
        <name>PAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326042</externalid>
        <name>TGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326046</externalid>
        <name>AREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326050</externalid>
        <name>EPGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326085</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-180292</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177929</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-182971</externalid>
    <name>EGFR downregulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-182971</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326375</externalid>
        <name>SH3GL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326381</externalid>
        <name>SH3GL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326046</externalid>
        <name>AREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326412</externalid>
        <name>SPRY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326365</externalid>
        <name>SH3KBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M839</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326007</externalid>
        <name>SH3GL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326451</externalid>
        <name>ARHGEF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326341</externalid>
        <name>EPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326349</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RS49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326466</externalid>
        <name>PTPRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MME1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326361</externalid>
        <name>EPS15L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326042</externalid>
        <name>TGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326353</externalid>
        <name>STAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N315</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326050</externalid>
        <name>EPGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326337</externalid>
        <name>EPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N579</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401250</externalid>
        <name>PTPN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIH4</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-182971</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177929</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190236</externalid>
    <name>Signaling by FGFR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190236</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381879</externalid>
        <name>FGFRL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314526</externalid>
        <name>HNRNPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>FGF22</name>
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          <protein>
            <xref>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGFR1</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2C</name>
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          <protein>
            <xref>
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              <externalid>Q3T0Q3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2F</name>
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          <protein>
            <xref>
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              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1NAV6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0MTF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGFBP1</name>
        <entity>
          <protein>
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              <externalid>Q9MZ06</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>KLB</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2L</name>
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          <protein>
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              <externalid>Q32P78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382222</externalid>
        <name>FLRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382226</externalid>
        <name>FLRT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MYF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF23</name>
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            <xref>
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              <externalid>E1BJU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348239</externalid>
        <name>GALNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314450</externalid>
        <name>PTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WN55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5654736</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654738</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654741</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654743</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190236</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654736</externalid>
    <name>Signaling by FGFR1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654736</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10381879</externalid>
        <name>FGFRL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382222</externalid>
        <name>FLRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382226</externalid>
        <name>FLRT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382230</externalid>
        <name>FLRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190242</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5658623</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654687</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654726</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654736</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190236</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190242</externalid>
    <name>FGFR1 ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190242</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190370</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190373</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190374</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190242</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190370</externalid>
    <name>FGFR1b ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190370</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190370</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190242</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190373</externalid>
    <name>FGFR1c ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190373</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190373</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190242</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190374</externalid>
    <name>FGFR1c and Klotho ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190374</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190374</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190242</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5658623</externalid>
    <name>FGFRL1 modulation of FGFR1 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5658623</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10381879</externalid>
        <name>FGFRL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5658623</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654687</externalid>
    <name>Downstream signaling of activated FGFR1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654687</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382222</externalid>
        <name>FLRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382226</externalid>
        <name>FLRT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382230</externalid>
        <name>FLRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5654693</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654219</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654688</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654689</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654687</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654693</externalid>
    <name>FRS-mediated FGFR1 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654693</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654693</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654219</externalid>
    <name>Phospholipase C-mediated cascade: FGFR1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654219</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654219</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654688</externalid>
    <name>SHC-mediated cascade:FGFR1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654688</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654688</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654689</externalid>
    <name>PI-3K cascade:FGFR1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654689</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654689</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654726</externalid>
    <name>Negative regulation of FGFR1 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654726</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1295596</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654726</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1295596</externalid>
    <name>Spry regulation of FGF signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1295596</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1295596</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654733</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654726</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654732</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654727</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654738</externalid>
    <name>Signaling by FGFR2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654738</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314526</externalid>
        <name>HNRNPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327106</externalid>
        <name>FGFBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314450</externalid>
        <name>PTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WN55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6803529</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190241</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654696</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654727</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654738</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190236</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6803529</externalid>
    <name>FGFR2 alternative splicing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6803529</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314526</externalid>
        <name>HNRNPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314450</externalid>
        <name>PTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WN55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6803529</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190241</externalid>
    <name>FGFR2 ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190241</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327106</externalid>
        <name>FGFBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190377</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190375</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190241</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>FGFR2b ligand binding and activation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327106</externalid>
        <name>FGFBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190377</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190241</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190375</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>FGF1</name>
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          <protein>
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              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF18</name>
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          <protein>
            <xref>
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              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190375</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190241</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654696</externalid>
    <name>Downstream signaling of activated FGFR2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654696</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5654700</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654221</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654699</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654695</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654696</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654700</externalid>
    <name>FRS-mediated FGFR2 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654700</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654700</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654696</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654221</externalid>
    <name>Phospholipase C-mediated cascade; FGFR2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654221</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654221</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654696</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654699</externalid>
    <name>SHC-mediated cascade:FGFR2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654699</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654699</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654696</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654695</externalid>
    <name>PI-3K cascade:FGFR2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654695</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654695</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654696</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654727</externalid>
    <name>Negative regulation of FGFR2 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654727</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1295596</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654727</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654738</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654741</externalid>
    <name>Signaling by FGFR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654741</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
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        <name>FGF9</name>
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          </protein>
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      <gene>
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        <name>PTPN11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>FGF2</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPRY2</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>PIK3CA</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>UBC</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>NRAS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GALNT3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FGFR3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
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          </protein>
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      <gene>
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        <name>Fgf4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>BRAF</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9760917</externalid>
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      <smallmolecule>
        <externalid>9736415</externalid>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>heparan sulfate</name>
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      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-190239</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5654708</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5654732</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654741</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190236</externalid>
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  <biosystem>
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    </biosystemtype>
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      <gene>
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      <gene>
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      <smallmolecule>
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        <name>heparan sulfate</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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        <name>FGFR3</name>
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              <externalid>A0A3Q1MPT9</externalid>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F2Z4J0</externalid>
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      <gene>
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      <gene>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>heparan sulfate</name>
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          <externalid>28815</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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    </smallmolecules>
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      </linkedsystem>
      <linkedsystem>
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  <biosystem>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        </entity>
      </gene>
      <gene>
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              <externalid>F2Z4J0</externalid>
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      </gene>
      <gene>
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      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348239</externalid>
        <name>GALNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190372</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190239</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654708</externalid>
    <name>Downstream signaling of activated FGFR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654708</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5654706</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654227</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654704</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654710</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654708</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654741</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654706</externalid>
    <name>FRS-mediated FGFR3 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654706</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654706</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654708</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654227</externalid>
    <name>Phospholipase C-mediated cascade; FGFR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654227</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654227</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654708</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654704</externalid>
    <name>SHC-mediated cascade:FGFR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654704</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654704</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654708</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654710</externalid>
    <name>PI-3K cascade:FGFR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654710</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654710</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654708</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654732</externalid>
    <name>Negative regulation of FGFR3 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654732</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>SRC</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>FRS2</name>
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          <protein>
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              <externalid>E1B7I9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FGF1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF18</name>
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          <protein>
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      <gene>
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        <name>FGF17</name>
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      </gene>
      <gene>
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        <name>MAPK3</name>
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              <externalid>E1B8P9</externalid>
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          </protein>
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      <gene>
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        <name>GRB2</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF16</name>
        <entity>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
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          <protein>
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              <externalid>E1BP37</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q08E39</externalid>
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          </protein>
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      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
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      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>A0MTF4</externalid>
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    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1295596</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1N339</externalid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>PIK3CA</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>NRAS</name>
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              <externalid>A5D7R9</externalid>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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          </protein>
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      <gene>
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        <name>PPP2R1A</name>
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          <protein>
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              <externalid>A5D973</externalid>
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          </protein>
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      <gene>
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        <name>FGF23</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>UBB</name>
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          </protein>
        </entity>
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      <gene>
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              <externalid>Q0IIE2</externalid>
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          </protein>
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      <gene>
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        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190322</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654716</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654733</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654743</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190236</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190322</externalid>
    <name>FGFR4 ligand binding and activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190322</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1307965</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190322</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654743</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1307965</externalid>
    <name>betaKlotho-mediated ligand binding</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1307965</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
      <gene>
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        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
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          <protein>
            <xref>
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              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KLB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1307965</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654716</externalid>
    <name>Downstream signaling of activated FGFR4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654716</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5654712</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654228</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654719</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654720</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654716</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654743</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654712</externalid>
    <name>FRS-mediated FGFR4 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654712</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654712</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654716</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654228</externalid>
    <name>Phospholipase C-mediated cascade; FGFR4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654228</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654228</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654716</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654719</externalid>
    <name>SHC-mediated cascade:FGFR4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654719</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654719</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654716</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654720</externalid>
    <name>PI-3K cascade:FGFR4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654720</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5654720</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654716</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5654733</externalid>
    <name>Negative regulation of FGFR4 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5654733</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349030</externalid>
        <name>MKNK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326407</externalid>
        <name>SPRY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1295596</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5654733</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5654743</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166520</externalid>
    <name>Signaling by NTRKs</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166520</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SRC</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>FRS2</name>
        <entity>
          <protein>
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              <externalid>E1B7I9</externalid>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>KRAS</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK11</name>
        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>SOS1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>GRB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10321246</externalid>
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          <protein>
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              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-9034015</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
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  <biosystem>
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        <name>PIK3R2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP2A1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383253</externalid>
        <name>SHC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YWHAB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATF1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DNAL4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KN5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RALGDS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SHC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MAPKAPK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>BRAF</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>AP2B1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VRK3</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS6KA5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN61</externalid>
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          </protein>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>zinc(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
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      <smallmolecule>
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        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-187015</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198203</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198765</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-177504</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198725</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-187037</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166520</externalid>
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    </linkedsystems>
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  <biosystem>
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    <name>Activation of TRKA receptors</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-187015</url>
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      <gene>
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      </linkedsystem>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>TRKA activation by NGF</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
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        </entity>
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    </genes>
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      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Signalling to ERKs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-187687</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>FRS2</name>
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              <externalid>E1B7I9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK14</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
        <entity>
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              <externalid>E1BMX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK11</name>
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          <protein>
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              <externalid>G3X793</externalid>
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          </protein>
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      <gene>
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        <name>SHC2</name>
        <entity>
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              <externalid>F1N5N3</externalid>
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      <gene>
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              <externalid>E1B8P9</externalid>
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      <gene>
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              <externalid>F1N7C3</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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        <name>NRAS</name>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>P46196</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RAP1A</name>
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        </entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>E1BQ32</externalid>
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        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK3</name>
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          <protein>
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              <externalid>Q3SYZ2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>BRAF</name>
        <entity>
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              <externalid>A0A3Q1M353</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAPGEF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
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            <xref>
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              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-167044</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-169893</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-187687</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-167044</externalid>
    <name>Signalling to RAS</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-167044</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383253</externalid>
        <name>SHC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374817</externalid>
        <name>SHC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324646</externalid>
        <name>RALGDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-171007</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-167044</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-171007</externalid>
    <name>p38MAPK events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-171007</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324646</externalid>
        <name>RALGDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-171007</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-167044</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-169893</externalid>
    <name>Prolonged ERK activation events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-169893</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324165</externalid>
        <name>KIDINS220</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323643</externalid>
        <name>NTRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-170968</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-170984</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-169893</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187687</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-170968</externalid>
    <name>Frs2-mediated activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-170968</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323643</externalid>
        <name>NTRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-170968</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-169893</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-170984</externalid>
    <name>ARMS-mediated activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-170984</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324165</externalid>
        <name>KIDINS220</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323643</externalid>
        <name>NTRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-170984</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-169893</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-198203</externalid>
    <name>PI3K/AKT activation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-198203</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323643</externalid>
        <name>NTRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-198203</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Signalling to ERK5</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>MAPK7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-198765</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-177504</externalid>
    <name>Retrograde neurotrophin signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CLTC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>NTRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ18</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP2A2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NGF</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-HSA-177504</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
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      <taxnode>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>Q0P594</externalid>
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          </protein>
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      <gene>
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              <externalid>G3X793</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK3</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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      <gene>
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          <protein>
            <xref>
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              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>DUSP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY43</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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              <externalid>A0A3Q1M614</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>Q2KJ36</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>NAB2</name>
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            <xref>
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              <externalid>Q1RMU0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329902</externalid>
        <name>ATF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410785</externalid>
        <name>EGR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328844</externalid>
        <name>RPS6KA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-198753</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199920</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9031628</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-198725</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-187037</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-198753</externalid>
    <name>ERK/MAPK targets</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-198753</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10331681</externalid>
        <name>DUSP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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      <gene>
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        <name>DUSP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY43</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MAPK7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VRK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN61</externalid>
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      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-202670</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-198753</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450282</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198725</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202670</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>DUSP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331669</externalid>
        <name>DUSP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY43</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MM08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
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          <protein>
            <xref>
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              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202670</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198753</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>CREB phosphorylation</name>
    <biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RPS6KA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATF1</name>
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          <protein>
            <xref>
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              <externalid>Q08DA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA5</name>
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          <protein>
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              <externalid>E1BN61</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-199920</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450282</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198725</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9031628</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10315820</externalid>
        <name>CHD4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410781</externalid>
        <name>NAB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410785</externalid>
        <name>EGR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198725</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9006115</externalid>
    <name>Signaling by NTRK2 (TRKB)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9006115</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367264</externalid>
        <name>NTRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LT44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367283</externalid>
        <name>NTF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367273</externalid>
        <name>BDNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9026527</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9028731</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9006115</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166520</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9026527</externalid>
    <name>Activated NTRK2 signals through PLCG1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9026527</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10367264</externalid>
        <name>NTRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LT44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367283</externalid>
        <name>NTF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367273</externalid>
        <name>BDNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9026527</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006115</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9028731</externalid>
    <name>Activated NTRK2 signals through FRS2 and FRS3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9028731</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367264</externalid>
        <name>NTRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LT44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367283</externalid>
        <name>NTF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367273</externalid>
        <name>BDNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9028731</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006115</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9034015</externalid>
    <name>Signaling by NTRK3 (TRKC)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9034015</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>240644</externalid>
        <name>NTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367297</externalid>
        <name>NTRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9034013</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9034793</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9603381</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9034015</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166520</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9034013</externalid>
    <name>NTF3 activates NTRK3 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9034013</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>240644</externalid>
        <name>NTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367297</externalid>
        <name>NTRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9034013</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9034015</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9034793</externalid>
    <name>Activated NTRK3 signals through PLCG1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9034793</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>240644</externalid>
        <name>NTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367297</externalid>
        <name>NTRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9034793</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9034015</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9603381</externalid>
    <name>Activated NTRK3 signals through PI3K</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9603381</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>240644</externalid>
        <name>NTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367297</externalid>
        <name>NTRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9603381</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9034015</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74752</externalid>
    <name>Signaling by Insulin receptor</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74752</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KL</name>
        <entity>
          <protein>
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              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
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              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
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              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE3B</name>
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          <protein>
            <xref>
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              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF22</name>
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          <protein>
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              <externalid>F1MQA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INSR</name>
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          <protein>
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              <externalid>F1MV64</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TLR9</name>
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          <protein>
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              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FLT3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP6V0E1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP6V1B2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316678</externalid>
        <name>PTPRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316638</externalid>
        <name>ATP6AP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40682</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FLT3LG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF16</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
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          </protein>
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      <gene>
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        <name>PIK3CB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PIK3R2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNN8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>FGFR4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>FGF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10316649</externalid>
        <name>CTSD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316657</externalid>
        <name>IDE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K02</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316520</externalid>
        <name>ATP6V0A4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FGF7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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    </genes>
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        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-74751</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77387</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74752</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74751</externalid>
    <name>Insulin receptor signalling cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74751</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316420</externalid>
        <name>INSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318815</externalid>
        <name>FLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316461</externalid>
        <name>GRB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-74713</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112399</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74749</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74751</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74713</externalid>
    <name>IRS activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74713</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316420</externalid>
        <name>INSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316461</externalid>
        <name>GRB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-74713</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74751</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112399</externalid>
    <name>IRS-mediated signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112399</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318815</externalid>
        <name>FLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-109704</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112412</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112399</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74751</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2428928</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-109704</externalid>
    <name>PI3K Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-109704</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318815</externalid>
        <name>FLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-165158</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109703</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-109704</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112399</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-165158</externalid>
    <name>Activation of AKT2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-165158</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-165158</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109704</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-109703</externalid>
    <name>PKB-mediated events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-109703</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-165160</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-109703</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109704</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-165160</externalid>
    <name>PDE3B signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-165160</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-165160</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-109703</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112412</externalid>
    <name>SOS-mediated signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112412</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-112412</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112399</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74749</externalid>
    <name>Signal attenuation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74749</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316420</externalid>
        <name>INSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316461</externalid>
        <name>GRB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-74749</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74751</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77387</externalid>
    <name>Insulin receptor recycling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77387</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316638</externalid>
        <name>ATP6AP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40682</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316512</externalid>
        <name>ATP6V0A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316420</externalid>
        <name>INSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316649</externalid>
        <name>CTSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316657</externalid>
        <name>IDE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316520</externalid>
        <name>ATP6V0A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316678</externalid>
        <name>PTPRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77387</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-186797</externalid>
    <name>Signaling by PDGF</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-186797</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334022</externalid>
        <name>SPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334052</externalid>
        <name>THBS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338002</externalid>
        <name>STAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332279</externalid>
        <name>GRB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338379</externalid>
        <name>COL6A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338317</externalid>
        <name>COL6A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB91</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338412</externalid>
        <name>COL6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COL4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7SIB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338542</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326563</externalid>
        <name>PDGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ15</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338006</externalid>
        <name>STAT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDGFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B1H0W5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THBS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337994</externalid>
        <name>STAT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95115</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326642</externalid>
        <name>RASA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326541</externalid>
        <name>PDGFRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N759</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337990</externalid>
        <name>STAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338348</externalid>
        <name>COL6A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338577</externalid>
        <name>COL5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338443</externalid>
        <name>COL6A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326524</externalid>
        <name>PDGFRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338622</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338307</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338476</externalid>
        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321910</externalid>
        <name>PLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337998</externalid>
        <name>STAT5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T878</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338618</externalid>
        <name>THBS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338511</externalid>
        <name>COL5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86341</externalid>
        <name>COL2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321920</externalid>
        <name>PLAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335159</externalid>
        <name>NCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338277</externalid>
        <name>PDGFC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338271</externalid>
        <name>PDGFD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792597</externalid>
        <name>heparan sulfate alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58388</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9792596</externalid>
        <name>heparan sulfate N-acetyl-alpha-D-glucosaminide polyanion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>70974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-186763</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-186797</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-186763</externalid>
    <name>Downstream signal transduction</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-186763</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>SRC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDGFB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B1H0W5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>STAT5A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q95115</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>STAT1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>F1N7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDGFRB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N759</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337990</externalid>
        <name>STAT3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BCAR1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332279</externalid>
        <name>GRB7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326524</externalid>
        <name>PDGFRA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MX49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CA</name>
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          <protein>
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              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337998</externalid>
        <name>STAT5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T878</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335159</externalid>
        <name>NCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326563</externalid>
        <name>PDGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338006</externalid>
        <name>STAT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-186763</externalid>
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        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328367</externalid>
        <name>FLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-194313</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4420097</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194306</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-194138</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-194313</externalid>
    <name>VEGF ligand-receptor interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-194313</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10328343</externalid>
        <name>KDR</name>
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          <protein>
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              <externalid>F1MWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328335</externalid>
        <name>VEGFA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P15691</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328325</externalid>
        <name>FLT4</name>
        <entity>
          <protein>
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              <externalid>F1MHP5</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10328353</externalid>
        <name>PGF</name>
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              <externalid>Q9XS47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328317</externalid>
        <name>FIGF</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MBB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328367</externalid>
        <name>FLT1</name>
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          <protein>
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              <externalid>F1MDD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328311</externalid>
        <name>VEGFC</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q9XS50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328359</externalid>
        <name>VEGFB</name>
        <entity>
          <protein>
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              <externalid>Q9XS49</externalid>
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          </protein>
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    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-195399</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-194313</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194138</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-195399</externalid>
    <name>VEGF binds to VEGFR leading to receptor dimerization</name>
    <biosystemtype>
      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-195399</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>KDR</name>
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      </gene>
      <gene>
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      </gene>
      <gene>
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      </gene>
      <gene>
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      </gene>
      <gene>
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        <name>FIGF</name>
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              <externalid>A7MBB6</externalid>
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      </gene>
      <gene>
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      <gene>
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        <name>VEGFC</name>
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      </gene>
      <gene>
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        <name>VEGFB</name>
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    </genes>
    <linkedsystems>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194313</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>VEGFA-VEGFR2 Pathway</name>
    <biosystemtype>
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    </taxonomy>
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      <gene>
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        <name>JUP</name>
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      </gene>
      <gene>
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              <externalid>F1MWF1</externalid>
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      </gene>
      <gene>
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        <name>SRC</name>
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              <externalid>E1BIM8</externalid>
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      </gene>
      <gene>
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        <name>DOCK1</name>
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              <externalid>F1MIX6</externalid>
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      </gene>
      <gene>
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        <name>MAPK14</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LTT9</externalid>
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      <gene>
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              <externalid>E1BMX0</externalid>
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      <gene>
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        <name>CTNND1</name>
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      <gene>
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        <name>MAPK11</name>
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      <gene>
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      <gene>
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              <externalid>A0A3Q1MR28</externalid>
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      </gene>
      <gene>
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        <name>MAPK13</name>
        <entity>
          <protein>
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              <externalid>Q5E9Q6</externalid>
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      </gene>
      <gene>
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        <name>PRKCZ</name>
        <entity>
          <protein>
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              <externalid>A0JNH7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RHOA</name>
        <entity>
          <protein>
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              <externalid>P61585</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MXS2</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>A0A3Q1M9M0</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
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              <externalid>P05126</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSPB1</name>
        <entity>
          <protein>
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              <externalid>Q3T149</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353688</externalid>
        <name>CYBA</name>
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              <externalid>O46521</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F1MFD1</externalid>
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      </gene>
      <gene>
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        <name>ROCK1</name>
        <entity>
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              <externalid>F1MF50</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PAK2</name>
        <entity>
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              <externalid>A0A3Q1M0G8</externalid>
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        </entity>
      </gene>
      <gene>
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        <name>PAK1</name>
        <entity>
          <protein>
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              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353706</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKI4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374043</externalid>
        <name>SHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374838</externalid>
        <name>SH2D2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z041</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339571</externalid>
        <name>PTK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340856</externalid>
        <name>ROCK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW77</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353702</externalid>
        <name>NCF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376837</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRN2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328335</externalid>
        <name>VEGFA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15691</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326642</externalid>
        <name>RASA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374817</externalid>
        <name>SHC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5N3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344691</externalid>
        <name>MAPK12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340754</externalid>
        <name>CDH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366694</externalid>
        <name>ELMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366690</externalid>
        <name>ELMO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQH0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335159</externalid>
        <name>NCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H720</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5218920</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5218921</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-4420097</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194138</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5218920</externalid>
    <name>VEGFR2 mediated vascular permeability</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5218920</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340814</externalid>
        <name>JUP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340820</externalid>
        <name>CTNND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335621</externalid>
        <name>CTNNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9M0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340754</externalid>
        <name>CDH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5218920</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4420097</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5218921</externalid>
    <name>VEGFR2 mediated cell proliferation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5218921</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328343</externalid>
        <name>KDR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328335</externalid>
        <name>VEGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15691</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326642</externalid>
        <name>RASA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365643</externalid>
        <name>PRKCZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5218921</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4420097</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-194306</externalid>
    <name>Neurophilin interactions with VEGF and VEGFR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-194306</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328343</externalid>
        <name>KDR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328541</externalid>
        <name>NRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328367</externalid>
        <name>FLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328549</externalid>
        <name>NRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-194306</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194138</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1433557</externalid>
    <name>Signaling by SCF-KIT</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1433557</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337994</externalid>
        <name>STAT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95115</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338002</externalid>
        <name>STAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332504</externalid>
        <name>FER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337990</externalid>
        <name>STAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332508</externalid>
        <name>TEC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332453</externalid>
        <name>SH2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316461</externalid>
        <name>GRB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332279</externalid>
        <name>GRB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332402</externalid>
        <name>KIT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355483</externalid>
        <name>PTPRU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355512</externalid>
        <name>GRAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355465</externalid>
        <name>MMP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52176</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332486</externalid>
        <name>PTPN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337998</externalid>
        <name>STAT5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T878</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332512</externalid>
        <name>FES</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355461</externalid>
        <name>LOC100139881</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352960</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332406</externalid>
        <name>KITLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332418</externalid>
        <name>YES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ5</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1433559</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1433557</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1433559</externalid>
    <name>Regulation of KIT signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1433559</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
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        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332486</externalid>
        <name>PTPN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SH2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KITLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LYN</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1433559</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1227986</externalid>
    <name>Signaling by ERBB2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1227986</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351928</externalid>
        <name>CUL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382609</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352026</externalid>
        <name>RNF41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355304</externalid>
        <name>USP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
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          </protein>
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        <name>CDC37</name>
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      <smallmolecule>
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      </gene>
      <gene>
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      <gene>
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              <externalid>E1BIN8</externalid>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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      </gene>
      <gene>
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              <externalid>F1MS28</externalid>
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          </protein>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-1963642</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
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  </biosystem>
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        <name>ERBB3</name>
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          </protein>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352026</externalid>
        <name>RNF41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354016</externalid>
        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355304</externalid>
        <name>USP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1358803</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8863795</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9652282</externalid>
    <name>Drug-mediated inhibition of ERBB2 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9652282</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360803</externalid>
        <name>CDC37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9652282</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1227986</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1236394</externalid>
    <name>Signaling by ERBB4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1236394</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337994</externalid>
        <name>STAT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95115</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354653</externalid>
        <name>WWOX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351738</externalid>
        <name>NEDD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354381</externalid>
        <name>ERBB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NRG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328086</externalid>
        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335866</externalid>
        <name>ESR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328078</externalid>
        <name>PSEN2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354661</externalid>
        <name>YAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
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          </protein>
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      <gene>
        <externalid>10328060</externalid>
        <name>PSENEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5G235</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
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              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NRG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS28</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-1250347</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1251985</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1253288</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1236394</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>SHC1 events in ERBB4 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1250347</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>NRAS</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354016</externalid>
        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354024</externalid>
        <name>NRG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1250347</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236394</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1250342</externalid>
    <name>PI3K events in ERBB4 signaling</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1250342</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354016</externalid>
        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
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          </protein>
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      <gene>
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        <name>NRG3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1250342</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236394</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1251985</externalid>
    <name>Nuclear signaling by ERBB4</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SRC</name>
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              <externalid>E1BIM8</externalid>
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          </protein>
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      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
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          <protein>
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              <externalid>A0A3Q1MDC6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337994</externalid>
        <name>STAT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95115</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10354653</externalid>
        <name>WWOX</name>
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          <protein>
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              <externalid>Q0P5N4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ESR1</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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        <name>PSENEN</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>YAP1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>PSEN1</name>
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          <protein>
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              <externalid>Q9XT97</externalid>
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          </protein>
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      <smallmolecule>
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        <name>estrogen</name>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <organism_specific_biosystem />
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      <taxnode>
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          </protein>
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      <gene>
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              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERBB4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
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          <protein>
            <xref>
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              <externalid>F1MGQ5</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>NEDD4</name>
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          <protein>
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              <externalid>F1MJ10</externalid>
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      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>UBB</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
    </genes>
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      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
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          </protein>
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      <gene>
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        <name>FRS2</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
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      <gene>
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        <name>GRB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>A6QLU3</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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            <xref>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1BAI2</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367707</externalid>
        <name>IGF1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K218</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367918</externalid>
        <name>IRS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338137</externalid>
        <name>IGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2428924</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2404192</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2428924</externalid>
    <name>IGF1R signaling cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2428924</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318815</externalid>
        <name>FLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367707</externalid>
        <name>IGF1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K218</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367918</externalid>
        <name>IRS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338137</externalid>
        <name>IGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2428933</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2428928</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2428924</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2404192</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2428933</externalid>
    <name>SHC-related events triggered by IGF1R</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2428933</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10367707</externalid>
        <name>IGF1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K218</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338137</externalid>
        <name>IGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2428933</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2428924</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2428928</externalid>
    <name>IRS-related events triggered by IGF1R</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2428928</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318847</externalid>
        <name>TRIB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318785</externalid>
        <name>FRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318627</externalid>
        <name>FGF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D8KXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318652</externalid>
        <name>KL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322294</externalid>
        <name>PDE3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318589</externalid>
        <name>FGF22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318595</externalid>
        <name>FGFR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318815</externalid>
        <name>FLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318843</externalid>
        <name>THEM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318585</externalid>
        <name>FGF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318777</externalid>
        <name>KLB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318573</externalid>
        <name>FGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318581</externalid>
        <name>FGF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318707</externalid>
        <name>FGF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318631</externalid>
        <name>FGF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318769</externalid>
        <name>FGF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367707</externalid>
        <name>IGF1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K218</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318809</externalid>
        <name>FLT3LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318703</externalid>
        <name>FGF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318853</externalid>
        <name>AKT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NH21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318635</externalid>
        <name>FGF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318551</externalid>
        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367918</externalid>
        <name>IRS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318736</externalid>
        <name>FGFR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338137</externalid>
        <name>IGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318670</externalid>
        <name>FGF7</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-112399</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2428928</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2428924</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6806834</externalid>
    <name>Signaling by MET</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6806834</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>9860807</externalid>
        <name>SRC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326375</externalid>
        <name>SH3GL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
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          </protein>
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      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10326381</externalid>
        <name>SH3GL3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX23</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355876</externalid>
        <name>COL11A2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRP6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10393820</externalid>
        <name>HPN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5C6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GAB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PTPN11</name>
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          </protein>
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      <gene>
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        <name>TNS4</name>
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              <externalid>Q32PJ7</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10383349</externalid>
        <name>RANBP9</name>
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              <externalid>A0A3Q1MPB6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SH3KBP1</name>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>MUC20</name>
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          </protein>
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      <gene>
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        <name>COL27A1</name>
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              <externalid>A0A3Q1M646</externalid>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>NRAS</name>
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              <externalid>A5D7R9</externalid>
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          </protein>
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      <gene>
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        <name>UBC</name>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F6RS49</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>G3N3N1</externalid>
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      <gene>
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        <name>RAP1A</name>
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      <gene>
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        <name>ITGB1</name>
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          </protein>
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      <gene>
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        <name>COL11A1</name>
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      <gene>
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      <gene>
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        <name>RAB4A</name>
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      <gene>
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          </protein>
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      <gene>
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        <name>HGFAC</name>
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              <externalid>E1BCW0</externalid>
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          </protein>
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      <gene>
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        <name>CRK</name>
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              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAPGEF1</name>
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          </protein>
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      <gene>
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              <externalid>G3N016</externalid>
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          </protein>
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      <gene>
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        <name>FN1</name>
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      <gene>
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              <externalid>F1MCK4</externalid>
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      <gene>
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        <name>CBL</name>
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              <externalid>A0A3Q1LN00</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>STAT3</name>
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              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COL5A3</name>
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              <externalid>F1MJQ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GGA3</name>
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              <externalid>A0A3Q1N3P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPINT2</name>
        <entity>
          <protein>
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              <externalid>Q2KJ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CA</name>
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          <protein>
            <xref>
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              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HGF</name>
        <entity>
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              <externalid>F1MZD6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DOCK7</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N3L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RANBP10</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MPW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGA2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MBA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN2</name>
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              <externalid>A5D982</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R1</name>
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          <protein>
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              <externalid>P23727</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>USP8</name>
        <entity>
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              <externalid>Q0IIM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STAM2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N315</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333631</externalid>
        <name>ITGA3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MMS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338511</externalid>
        <name>COL5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393829</externalid>
        <name>SPINT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402633</externalid>
        <name>TNS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86341</externalid>
        <name>COL2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326237</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331050</externalid>
        <name>PTPRJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6K1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6806942</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8851805</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8851907</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8865999</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875878</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875791</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875656</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807004</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6806834</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6806942</externalid>
    <name>MET Receptor Activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6806942</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393829</externalid>
        <name>SPINT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393833</externalid>
        <name>SPINT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393820</externalid>
        <name>HPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393853</externalid>
        <name>HGFAC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6806942</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8851805</externalid>
    <name>MET activates RAS signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8851805</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383349</externalid>
        <name>RANBP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399109</externalid>
        <name>RANBP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348182</externalid>
        <name>MUC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8851805</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8851907</externalid>
    <name>MET activates PI3K/AKT signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8851907</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8851907</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8865999</externalid>
    <name>MET activates PTPN11</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8865999</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8865999</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8875878</externalid>
    <name>MET promotes cell motility</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8875878</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338577</externalid>
        <name>COL5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355876</externalid>
        <name>COL11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402641</externalid>
        <name>TNS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356537</externalid>
        <name>COL27A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M646</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353098</externalid>
        <name>DOCK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338476</externalid>
        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334258</externalid>
        <name>ITGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355821</externalid>
        <name>COL11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338542</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333631</externalid>
        <name>ITGA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338511</externalid>
        <name>COL5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402633</externalid>
        <name>TNS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86341</externalid>
        <name>COL2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8874081</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875513</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875555</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8875878</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6806834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8874081</externalid>
    <name>MET activates PTK2 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8874081</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338476</externalid>
        <name>COL3A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334258</externalid>
        <name>ITGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355821</externalid>
        <name>COL11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338577</externalid>
        <name>COL5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338542</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355876</externalid>
        <name>COL11A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333631</externalid>
        <name>ITGA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338511</externalid>
        <name>COL5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>86341</externalid>
        <name>COL2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356537</externalid>
        <name>COL27A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M646</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8874081</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875878</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8875513</externalid>
    <name>MET interacts with TNS proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8875513</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402633</externalid>
        <name>TNS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402641</externalid>
        <name>TNS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8875513</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875878</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8875555</externalid>
    <name>MET activates RAP1 and RAC1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8875555</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345776</externalid>
        <name>HGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353098</externalid>
        <name>DOCK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8875555</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8875878</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>MET activates STAT3</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MET</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STAT3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>MET receptor recycling</name>
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      <organism_specific_biosystem />
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      <taxnode>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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        <name>MET</name>
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      <gene>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <linkedsystem>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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        <name>USP8</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
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      <gene>
        <externalid>10330383</externalid>
        <name>ALK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330387</externalid>
        <name>PTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330413</externalid>
        <name>MDK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N0E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9851151</externalid>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9701898</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-201556</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006934</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9851151</externalid>
    <name>MDK and PTN in ALK signaling</name>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9851151</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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          <protein>
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      <gene>
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        <name>PTN</name>
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          <protein>
            <xref>
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      <gene>
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        <name>PTPRZ1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGK5</externalid>
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      <gene>
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          <protein>
            <xref>
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    </genes>
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      <smallmolecule>
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        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201556</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>STAT3 nuclear events downstream of ALK signaling</name>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    <name>Signaling by TGFB family members</name>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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        <name>WWTR1</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MBE6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFBR1</name>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>E1BEG4</externalid>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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      </gene>
      <gene>
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        <name>NCOR1</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      </gene>
      <gene>
        <externalid>10353778</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSN4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365631</externalid>
        <name>CGN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374651</externalid>
        <name>NEDD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61282</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TFDP1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SKI</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N727</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SNW1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1JQE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFBR2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B702</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>TGIF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MIB9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGIF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RNF111</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FKBP1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BAMBI</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367390</externalid>
        <name>LTBP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF86</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SMURF2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333649</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2M</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N172</externalid>
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          </protein>
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      <gene>
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        <name>STUB1</name>
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              <externalid>E1B7G3</externalid>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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      <gene>
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          </protein>
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      <gene>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2173789</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-170834</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006936</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2173789</externalid>
    <name>TGF-beta receptor signaling activates SMADs</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2173789</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>SMAD7</name>
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              <externalid>A0A3Q1M0Z8</externalid>
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        </entity>
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      <gene>
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              <externalid>A0A3Q1N449</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>SMAD4</name>
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          <protein>
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              <externalid>B0JYL0</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>A0A3Q1MDQ2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CBL</name>
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          <protein>
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              <externalid>A0A3Q1LN00</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MTMR4</name>
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              <externalid>A0A3Q1MQY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGB3</name>
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              <externalid>F1MTN1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>P61282</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGAV</name>
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              <externalid>A0A3Q1MXS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMAD3</name>
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          <protein>
            <xref>
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              <externalid>F1MUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFBR3</name>
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              <externalid>E1B9H5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ITGB8</name>
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              <externalid>F1MVW3</externalid>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>STRAP</name>
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              <externalid>Q5E959</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMAD2</name>
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              <externalid>E1BE92</externalid>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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      </gene>
      <gene>
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        <name>TGFBR2</name>
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              <externalid>E1B702</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FBN1</name>
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              <externalid>P98133</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFBR1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O46680</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGFB2</name>
        <entity>
          <protein>
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              <externalid>P21214</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP4</name>
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          <protein>
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              <externalid>G3MZT8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BAMBI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FKBP1A</name>
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          <protein>
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              <externalid>P18203</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ITGB1</name>
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          <protein>
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              <externalid>A0A140T8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FURIN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZFYVE9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MF86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333707</externalid>
        <name>ITGB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352220</externalid>
        <name>UBE2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333657</externalid>
        <name>ITGB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N444</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2173788</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2173789</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-170834</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SMAD7</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>BAMBI</name>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>STUB1</name>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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          <superset />
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      </linkedsystem>
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      <taxnode>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <linkedsystem>
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          <superset />
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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            <xref>
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          </protein>
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      <gene>
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        <name>CCNC</name>
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          <protein>
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              <externalid>Q3ZCK5</externalid>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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          </protein>
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          <protein>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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        <entity>
          <protein>
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          </protein>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
            <xref>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      </gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TGIF2</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBL1</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>NAD(1-)</name>
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      <smallmolecule>
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      <smallmolecule>
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        <name>nicotinamide</name>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-2173796</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2173793</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-170834</externalid>
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          <superset />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
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          <superset />
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
        <externalid>10332522</externalid>
        <name>PPM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62829</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324723</externalid>
        <name>SKIL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2173795</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173793</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-201451</externalid>
    <name>Signaling by BMP</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-201451</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324747</externalid>
        <name>SMAD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330772</externalid>
        <name>CER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324545</externalid>
        <name>SMAD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367596</externalid>
        <name>BMP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8X7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330272</externalid>
        <name>BMPR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330784</externalid>
        <name>NOG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330776</externalid>
        <name>CHRDL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330284</externalid>
        <name>ACVR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28043</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330266</externalid>
        <name>BMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324719</externalid>
        <name>SKI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330292</externalid>
        <name>BMPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330330</externalid>
        <name>SMURF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330368</externalid>
        <name>SMAD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400368</externalid>
        <name>GDF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330232</externalid>
        <name>SMAD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330780</externalid>
        <name>FSTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330276</externalid>
        <name>BMPR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330288</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330226</externalid>
        <name>SMAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400364</externalid>
        <name>ACVRL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330339</externalid>
        <name>ZFYVE16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400348</externalid>
        <name>SF3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330238</externalid>
        <name>SMAD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400354</externalid>
        <name>AMHR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-201451</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006936</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1502540</externalid>
    <name>Signaling by Activin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1502540</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357233</externalid>
        <name>ACVR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324545</externalid>
        <name>SMAD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336055</externalid>
        <name>INHBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330288</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368393</externalid>
        <name>FST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50291</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330284</externalid>
        <name>ACVR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28043</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324491</externalid>
        <name>SMAD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353634</externalid>
        <name>ACVR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324487</externalid>
        <name>SMAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2473224</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1502540</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006936</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2473224</externalid>
    <name>Antagonism of Activin by Follistatin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2473224</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336055</externalid>
        <name>INHBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368393</externalid>
        <name>FST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50291</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2473224</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1502540</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9839373</externalid>
    <name>Signaling by TGFBR3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9839373</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324463</externalid>
        <name>TGFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N449</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324457</externalid>
        <name>TGFBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356469</externalid>
        <name>MMP14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324469</externalid>
        <name>TGFBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324532</externalid>
        <name>TGFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357967</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N430</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328078</externalid>
        <name>PSEN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358172</externalid>
        <name>MMP16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N797</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345830</externalid>
        <name>LOC112442231</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330284</externalid>
        <name>ACVR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28043</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328060</externalid>
        <name>PSENEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5G235</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328086</externalid>
        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9839383</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839389</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839406</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839397</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9839373</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006936</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9839383</externalid>
    <name>TGFBR3 PTM regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9839383</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356469</externalid>
        <name>MMP14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357967</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N430</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328060</externalid>
        <name>PSENEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5G235</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328078</externalid>
        <name>PSEN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358172</externalid>
        <name>MMP16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N797</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328086</externalid>
        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345830</externalid>
        <name>LOC112442231</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9839383</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839373</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9839389</externalid>
    <name>TGFBR3 regulates TGF-beta signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9839389</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324463</externalid>
        <name>TGFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N449</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324457</externalid>
        <name>TGFBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B702</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324469</externalid>
        <name>TGFBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324532</externalid>
        <name>TGFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9839389</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839373</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9839406</externalid>
    <name>TGFBR3 regulates activin signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9839406</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330284</externalid>
        <name>ACVR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28043</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9839406</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839373</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9839397</externalid>
    <name>TGFBR3 regulates FGF2 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9839397</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318577</externalid>
        <name>FGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03969</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324528</externalid>
        <name>TGFBR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9839397</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9839373</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-372790</externalid>
    <name>Signaling by GPCR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-372790</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336207</externalid>
        <name>GPHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336823</externalid>
        <name>TAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01289</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340889</externalid>
        <name>MCF2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349452</externalid>
        <name>GPR77</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340993</externalid>
        <name>ARHGEF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334933</externalid>
        <name>CCL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296453</externalid>
        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-500792</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-372790</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-500792</externalid>
    <name>GPCR ligand binding</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-500792</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10336207</externalid>
        <name>GPHA2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BD70</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336380</externalid>
        <name>ADCYAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336823</externalid>
        <name>TAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01289</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337172</externalid>
        <name>CXCR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349452</externalid>
        <name>GPR77</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334933</externalid>
        <name>CCL19</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337392</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335274</externalid>
        <name>CXCL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80221</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337420</externalid>
        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>F2RL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337099</externalid>
        <name>GPR143</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E581</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390875</externalid>
        <name>PLPPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337194</externalid>
        <name>HTR1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336679</externalid>
        <name>P2RY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343646</externalid>
        <name>CCL22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347551</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337015</externalid>
        <name>GPR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412608</externalid>
        <name>S1PR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335371</externalid>
        <name>OPRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N083</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337186</externalid>
        <name>HTR1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335486</externalid>
        <name>CORT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N364</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337330</externalid>
        <name>PPY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336117</externalid>
        <name>DRD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321082</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335496</externalid>
        <name>SSTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEN6</externalid>
            </xref>
          </protein>
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      <gene>
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      <gene>
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        <name>CCL27</name>
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      <gene>
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        <name>HCRT</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>LHB</name>
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          <protein>
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      <gene>
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        <name>AVPR1A</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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        <name>UTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>UDP-alpha-D-glucose(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>colchicine</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>sucrose</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
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      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
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      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
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      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
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      <smallmolecule>
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        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
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      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
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      <smallmolecule>
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        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
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      <smallmolecule>
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        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
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      <smallmolecule>
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        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
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      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
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          <externalid>16296</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373080</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-420499</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-500792</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-372790</externalid>
        <linkedsystemtype>
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    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-373076</externalid>
    <name>Class A/1 (Rhodopsin-like receptors)</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-373076</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336615</externalid>
        <name>ADRA1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336655</externalid>
        <name>AVPR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PV87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334955</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337360</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929641</externalid>
        <name>kynurenate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58454</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916387</externalid>
        <name>(18S)-resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136057</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916406</externalid>
        <name>resolvin E1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91000</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-375276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375281</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391903</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418038</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3296197</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-419408</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-419771</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-444209</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-373076</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-500792</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-375276</externalid>
    <name>Peptide ligand-binding receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-375276</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336757</externalid>
        <name>EDN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336823</externalid>
        <name>TAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01289</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337172</externalid>
        <name>CXCR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337166</externalid>
        <name>AGTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349452</externalid>
        <name>GPR77</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337176</externalid>
        <name>CXCL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334933</externalid>
        <name>CCL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335053</externalid>
        <name>XCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334947</externalid>
        <name>CCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN72</externalid>
            </xref>
          </protein>
        </entity>
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              <sourcename>UniProt</sourcename>
              <externalid>O77801</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RXFP2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336883</externalid>
        <name>HCRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56717</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335027</externalid>
        <name>CCL27</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MZ86</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP23</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCRL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336655</externalid>
        <name>AVPR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PV87</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GALR2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QLK3</externalid>
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          </protein>
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      <gene>
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        <name>SSTR5</name>
        <entity>
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              <externalid>F1MV99</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388479</externalid>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389397</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-444821</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-375276</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Chemokine receptors bind chemokines</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CXCR5</name>
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              <externalid>G3N3U0</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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      <gene>
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        <name>CCL19</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>XCL2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BH62</externalid>
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          </protein>
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      <gene>
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        <name>CCR1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0JN72</externalid>
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      <gene>
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        <name>CXCR2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHN9</externalid>
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          </protein>
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      <gene>
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        <name>CXCL6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80221</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CCL20</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB1</externalid>
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          </protein>
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      <gene>
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        <name>CCL25</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDJ2</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M976</externalid>
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          </protein>
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      <gene>
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        <name>CCL22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKF1</externalid>
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          </protein>
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      <gene>
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        <name>CXCL10</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KIQ8</externalid>
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          </protein>
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      <gene>
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          <protein>
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        <entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            <xref>
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          </protein>
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            <xref>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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          <protein>
            <xref>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          <protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>LOC616364</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CCL27</name>
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      <gene>
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          </protein>
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          </protein>
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    </genes>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <gene>
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        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-390648</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390696</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390651</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390650</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390666</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-375280</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390648</externalid>
    <name>Muscarinic acetylcholine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390648</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336595</externalid>
        <name>CHRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5C5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336603</externalid>
        <name>CHRM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336599</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337234</externalid>
        <name>CHRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P41985</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390648</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390696</externalid>
    <name>Adrenoceptors</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390696</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
        <externalid>10336619</externalid>
        <name>ADRA1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7W0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336107</externalid>
        <name>ADRB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQZ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336615</externalid>
        <name>ADRA1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336095</externalid>
        <name>ADRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R653</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336611</externalid>
        <name>ADRA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336101</externalid>
        <name>ADRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28044</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390696</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390651</externalid>
    <name>Dopamine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390651</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
      <gene>
        <externalid>10336117</externalid>
        <name>DRD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412127</externalid>
        <name>DRD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337212</externalid>
        <name>DRD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N454</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336113</externalid>
        <name>DRD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95136</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390651</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390650</externalid>
    <name>Histamine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390650</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
        <externalid>10412838</externalid>
        <name>HRH3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MML8</externalid>
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      </gene>
      <gene>
        <externalid>10337206</externalid>
        <name>HRH4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336125</externalid>
        <name>HRH2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390650</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390666</externalid>
    <name>Serotonin receptors</name>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390666</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10337190</externalid>
        <name>HTR1E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337198</externalid>
        <name>HTR5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336135</externalid>
        <name>HTR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336139</externalid>
        <name>HTR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336131</externalid>
        <name>HTR4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LFQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412031</externalid>
        <name>HTR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q2H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336627</externalid>
        <name>HTR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337194</externalid>
        <name>HTR1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337186</externalid>
        <name>HTR1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336631</externalid>
        <name>HTR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QI78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337182</externalid>
        <name>HTR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390666</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-375280</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-375281</externalid>
    <name>Hormone ligand-binding receptors</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-375281</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>GPHA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BD70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336191</externalid>
        <name>FSHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336197</externalid>
        <name>LHCGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T893</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336639</externalid>
        <name>GNRH1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBW7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336203</externalid>
        <name>TSHR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336649</externalid>
        <name>GNRHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32236</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336049</externalid>
        <name>FSHB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336211</externalid>
        <name>GPB5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A0F7RPV8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336643</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J7</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-375281</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-391903</externalid>
    <name>Eicosanoid ligand-binding receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-391903</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336470</externalid>
        <name>PTGDR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336480</externalid>
        <name>PTGER4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336815</externalid>
        <name>LTB4R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336923</externalid>
        <name>PTGER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336247</externalid>
        <name>PTGIR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336715</externalid>
        <name>TBXA2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336775</externalid>
        <name>GPR17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VEA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336476</externalid>
        <name>PTGER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336727</externalid>
        <name>CYSLTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336811</externalid>
        <name>LTB4R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337308</externalid>
        <name>PTGDR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N2W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337360</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336721</externalid>
        <name>CYSLTR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336929</externalid>
        <name>PTGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337366</externalid>
        <name>PTGER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P34979</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-391908</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391906</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-391903</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-391908</externalid>
    <name>Prostanoid ligand receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-391908</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336247</externalid>
        <name>PTGIR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336470</externalid>
        <name>PTGDR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336480</externalid>
        <name>PTGER4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336715</externalid>
        <name>TBXA2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336476</externalid>
        <name>PTGER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336923</externalid>
        <name>PTGER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337308</externalid>
        <name>PTGDR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N2W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336929</externalid>
        <name>PTGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337366</externalid>
        <name>PTGER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P34979</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-391908</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391903</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-391906</externalid>
    <name>Leukotriene receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-391906</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336815</externalid>
        <name>LTB4R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336775</externalid>
        <name>GPR17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VEA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336727</externalid>
        <name>CYSLTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336811</externalid>
        <name>LTB4R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336721</externalid>
        <name>CYSLTR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-391906</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391903</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418038</externalid>
    <name>Nucleotide-like (purinergic) receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418038</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336673</externalid>
        <name>P2RY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337258</externalid>
        <name>ADORA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336257</externalid>
        <name>ADORA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336685</externalid>
        <name>P2RY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337240</externalid>
        <name>P2RY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336691</externalid>
        <name>LPAR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336464</externalid>
        <name>P2RY11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337262</externalid>
        <name>ADORA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336253</externalid>
        <name>ADORA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336667</externalid>
        <name>P2RY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48042</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336775</externalid>
        <name>GPR17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VEA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337246</externalid>
        <name>P2RY12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337252</externalid>
        <name>P2RY14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336679</externalid>
        <name>P2RY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-417957</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-417973</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418038</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-417957</externalid>
    <name>P2Y receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-417957</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336464</externalid>
        <name>P2RY11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336673</externalid>
        <name>P2RY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336667</externalid>
        <name>P2RY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48042</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336775</externalid>
        <name>GPR17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VEA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337246</externalid>
        <name>P2RY12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337252</externalid>
        <name>P2RY14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336685</externalid>
        <name>P2RY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337240</externalid>
        <name>P2RY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336691</externalid>
        <name>LPAR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336679</externalid>
        <name>P2RY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-417957</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418038</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-417973</externalid>
    <name>Adenosine P1 receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-417973</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337262</externalid>
        <name>ADORA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336253</externalid>
        <name>ADORA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337258</externalid>
        <name>ADORA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336257</externalid>
        <name>ADORA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-417973</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418038</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3296197</externalid>
    <name>Hydroxycarboxylic acid-binding receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3296197</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337512</externalid>
        <name>HCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B9UM28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337518</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N168</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3296197</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-419408</externalid>
    <name>Lysosphingolipid and LPA receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-419408</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10412608</externalid>
        <name>S1PR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336799</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337384</externalid>
        <name>S1PR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390871</externalid>
        <name>PLPPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336803</externalid>
        <name>LPAR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337372</externalid>
        <name>S1PR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336791</externalid>
        <name>LPAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337380</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390867</externalid>
        <name>PLPPR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390875</externalid>
        <name>PLPPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336795</externalid>
        <name>LPAR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337376</externalid>
        <name>S1PR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390879</externalid>
        <name>PLPPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390883</externalid>
        <name>PLPPR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-419408</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-419771</externalid>
    <name>Opsins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-419771</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341071</externalid>
        <name>RRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341055</externalid>
        <name>OPN1LW</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BGI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336703</externalid>
        <name>OPN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341067</externalid>
        <name>RGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P47803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341063</externalid>
        <name>OPN5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341059</externalid>
        <name>OPN1SW</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P51490</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-419771</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-444209</externalid>
    <name>Free fatty acid receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-444209</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337009</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B9VJW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337572</externalid>
        <name>GPR31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337003</externalid>
        <name>GPR43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B9VJV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-444209</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373076</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-373080</externalid>
    <name>Class B/2 (Secretin family receptors)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-373080</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336380</externalid>
        <name>ADCYAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336398</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336325</externalid>
        <name>GIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336235</externalid>
        <name>CALCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336414</externalid>
        <name>PTH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01268</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336231</externalid>
        <name>CALC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336418</externalid>
        <name>PTHLH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403775</externalid>
        <name>CRHBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336277</externalid>
        <name>RAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336283</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336265</externalid>
        <name>CT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B5UBG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336358</externalid>
        <name>GHRHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TUJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347551</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336408</externalid>
        <name>PTH1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336368</externalid>
        <name>VIPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336335</externalid>
        <name>GLP1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343800</externalid>
        <name>ADGRE5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336269</externalid>
        <name>CALCR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q8B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403783</externalid>
        <name>UCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336346</externalid>
        <name>GLP2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403787</externalid>
        <name>UCN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343796</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336372</externalid>
        <name>VIPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343804</externalid>
        <name>LOC508459</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336315</externalid>
        <name>CRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95MI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336394</externalid>
        <name>SCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336364</externalid>
        <name>VIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81401</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336329</externalid>
        <name>GIPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336239</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336422</externalid>
        <name>PTH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343808</externalid>
        <name>ADGRE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E538</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336388</externalid>
        <name>ADCYAP1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29627</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9T2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336297</externalid>
        <name>ADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336354</externalid>
        <name>GHRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63292</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336291</externalid>
        <name>IAPP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336319</externalid>
        <name>CRHR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336404</externalid>
        <name>PTH2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322990</externalid>
        <name>GCGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-419812</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-420092</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-373080</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-500792</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-419812</externalid>
    <name>Calcitonin-like ligand receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-419812</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10336297</externalid>
        <name>ADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336235</externalid>
        <name>CALCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336231</externalid>
        <name>CALC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336291</externalid>
        <name>IAPP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336277</externalid>
        <name>RAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336269</externalid>
        <name>CALCR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q8B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336239</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9T2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336283</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336265</externalid>
        <name>CT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B5UBG1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-419812</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373080</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-420092</externalid>
    <name>Glucagon-type ligand receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10336380</externalid>
        <name>ADCYAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336372</externalid>
        <name>VIPR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336398</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336394</externalid>
        <name>SCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336325</externalid>
        <name>GIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336329</externalid>
        <name>GIPR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336364</externalid>
        <name>VIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336388</externalid>
        <name>ADCYAP1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29627</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336358</externalid>
        <name>GHRHR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TUJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GHRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63292</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>VIPR1</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GCGR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>GLP1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG12</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GLP2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAY1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-420092</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373080</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-420499</externalid>
    <name>Class C/3 (Metabotropic glutamate/pheromone receptors)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-420499</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>TAS1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAS2R42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335007</externalid>
        <name>GRM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335011</externalid>
        <name>GRM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N213</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAS2R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZA1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIP5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337458</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAS2R3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>T2R65A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337578</externalid>
        <name>GABBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF15</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337470</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8B7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337484</externalid>
        <name>TAS2R60</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N090</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337602</externalid>
        <name>TAS1R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334985</externalid>
        <name>GRM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334981</externalid>
        <name>GRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334995</externalid>
        <name>GRM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337424</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337594</externalid>
        <name>TAS1R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NND8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337432</externalid>
        <name>TAS2R46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337488</externalid>
        <name>TAS2R7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336709</externalid>
        <name>CASR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35384</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337410</externalid>
        <name>T2R10C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337406</externalid>
        <name>TAS2R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337466</externalid>
        <name>TAS2R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2ABC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334999</externalid>
        <name>GRM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B965</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337428</externalid>
        <name>LOC782957</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296453</externalid>
        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-420499</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-500792</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-388396</externalid>
    <name>GPCR downstream signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-388396</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10336207</externalid>
        <name>GPHA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336823</externalid>
        <name>TAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01289</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340889</externalid>
        <name>MCF2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340993</externalid>
        <name>ARHGEF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334933</externalid>
        <name>CCL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337392</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10335274</externalid>
        <name>CXCL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80221</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337420</externalid>
        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
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          </protein>
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      <gene>
        <externalid>10320259</externalid>
        <name>F2RL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB7</externalid>
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          </protein>
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      <gene>
        <externalid>10341900</externalid>
        <name>DGKQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296453</externalid>
        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760819</externalid>
        <name>lithocholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29744</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9957264</externalid>
        <name>deoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23614</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
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      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
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      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-418555</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-418594</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-418597</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-416476</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-416482</externalid>
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      <linkedsystem>
        <externalid>R-BTA-397795</externalid>
        <linkedsystemtype>
          <subset />
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      <linkedsystem>
        <externalid>R-HSA-388396</externalid>
        <linkedsystemtype>
          <linked />
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      <linkedsystem>
        <externalid>R-BTA-372790</externalid>
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          <superset />
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>VIPR1</name>
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          </protein>
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      <gene>
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        <name>HTR6</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PTH2</name>
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          </protein>
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      <gene>
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        <name>GNB3</name>
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          </protein>
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      <gene>
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        <name>PRKACA</name>
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          </protein>
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      </gene>
      <gene>
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        <name>GPR84</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
        <externalid>10336502</externalid>
        <entity>
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            <xref>
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          </protein>
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      <gene>
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        <name>LOC516101</name>
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          </protein>
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      </gene>
      <gene>
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        <name>GPR176</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>GPR25</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>TAAR2</name>
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          </protein>
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      <gene>
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            <xref>
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          </protein>
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      <gene>
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        <name>GPB5</name>
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          </protein>
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      <gene>
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        <name>RXFP2</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>INSL3</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>ARRB2</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>FSHR</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>PDE4D</name>
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          </protein>
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      <gene>
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        <name>LHB</name>
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          <protein>
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      <gene>
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      <gene>
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        <name>lithocholate</name>
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      <smallmolecule>
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      <smallmolecule>
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        <name>prostaglandin E2(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>zinc(2+)</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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        </xref>
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      <smallmolecule>
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        <name>cholate</name>
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        </xref>
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      <smallmolecule>
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        <name>histaminium</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
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      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>141189</externalid>
        <name>2-phenylethylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915618</externalid>
        <name>prostaglandin I2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57403</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9634597</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418555</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9634597</externalid>
    <name>GPER1 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9634597</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>93433</externalid>
        <name>ITGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27977</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9634597</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418555</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418594</externalid>
    <name>G alpha (i) signalling events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418594</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10337172</externalid>
        <name>CXCR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407714</externalid>
        <name>RGS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46471</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334933</externalid>
        <name>CCL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337392</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335274</externalid>
        <name>CXCL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80221</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337420</externalid>
        <name>TAS2R16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10337194</externalid>
        <name>HTR1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OPRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N083</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HTR1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326276</externalid>
        <name>PPP1CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335486</externalid>
        <name>CORT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N364</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337330</externalid>
        <name>PPY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321082</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SSTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CXCL3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CXCR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLCB4</name>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>C5</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GAL</name>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>SST</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAS1R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MTNR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYN7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CXCR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>CHRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLE8</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCR6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>T2R65A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>PDE1A</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS13</name>
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      </gene>
      <gene>
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        <name>RGS17</name>
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          <protein>
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              <externalid>A7MBG6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10337198</externalid>
        <name>HTR5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398796</externalid>
        <name>RGS6</name>
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          <protein>
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              <externalid>A0A3Q1MFC7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335045</externalid>
        <name>CCL20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337492</externalid>
        <name>TAS2R8</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337372</externalid>
        <name>S1PR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDV6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BHU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR2B</name>
        <entity>
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              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>A0A3Q1MA58</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPYR1</name>
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              <externalid>F1MKB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CXCL10</name>
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          <protein>
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              <externalid>Q2KIQ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS19</name>
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          <protein>
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              <externalid>Q08DC7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GPR31</name>
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          <protein>
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              <externalid>F1N1J4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCL28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6YT15</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337594</externalid>
        <name>TAS1R3</name>
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          <protein>
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              <externalid>A0A3Q1NND8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS18</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMB5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335375</externalid>
        <name>OPRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIP6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>P2RY12</name>
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          <protein>
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              <externalid>Q0IIL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368842</externalid>
        <name>RGS9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
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          <protein>
            <xref>
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              <externalid>Q0VCW5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
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              <externalid>O46677</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS4</name>
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              <externalid>Q29RM9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RGS8</name>
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          <protein>
            <xref>
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              <externalid>E1B7H3</externalid>
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          </protein>
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      <gene>
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        <name>ADORA3</name>
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              <externalid>Q0VC81</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335089</externalid>
        <name>CXCL16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334911</externalid>
        <name>CCR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335528</externalid>
        <name>NPBWR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5J0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337380</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336795</externalid>
        <name>LPAR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLD8</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335278</externalid>
        <name>CXCL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79255</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337326</externalid>
        <name>NPY</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6RUW3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341059</externalid>
        <name>OPN1SW</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P51490</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335355</externalid>
        <name>CXCR3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5MD61</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335520</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTH9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336502</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321746</externalid>
        <name>KNG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337506</externalid>
        <name>OXGR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYN3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335027</externalid>
        <name>CCL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9865249</externalid>
        <name>PDE4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6Q5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334955</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10337360</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCJ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296396</externalid>
        <name>hydroquinone O-beta-D-glucopyranoside</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31767</externalid>
        <name>salicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17814</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296421</externalid>
        <name>colchicine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>23359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296402</externalid>
        <name>arborescin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29520</externalid>
        <name>sucrose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17992</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296455</externalid>
        <name>picrotoxinin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8206</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915652</externalid>
        <name>prostaglandin D2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37927</externalid>
        <name>coumarin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296453</externalid>
        <name>alpha-thujone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50042</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114801</externalid>
        <name>(S)-lactic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42389</externalid>
        <name>amygdalin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>517532</externalid>
        <name>N-arachidonoylglycine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58961</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296384</externalid>
        <name>aristolochic acid A</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296385</externalid>
        <name>erythromycin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869623</externalid>
        <name>nicotinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296383</externalid>
        <name>ethylpyrazine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73232</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296408</externalid>
        <name>camphor</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296393</externalid>
        <name>allyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296317</externalid>
        <name>3-hydroxybutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296409</externalid>
        <name>cucurbitacin E</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3944</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296405</externalid>
        <name>Grosshemin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>5547</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114777</externalid>
        <name>D-fructose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15824</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114909</externalid>
        <name>caffeine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27732</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296438</externalid>
        <name>arglabin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296389</externalid>
        <name>brucine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3193</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42582</externalid>
        <name>sinigrin(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9162</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296398</externalid>
        <name>papaverine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28241</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296419</externalid>
        <name>andrographolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65408</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915883</externalid>
        <name>12(S)-HETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90680</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30953</externalid>
        <name>chloramphenicol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17698</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296415</externalid>
        <name>Cnicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296449</externalid>
        <name>phenethyl isothiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>351346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444696</externalid>
        <name>saccharin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32111</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296391</externalid>
        <name>crispolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73231</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296429</externalid>
        <name>aloin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73222</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38945</externalid>
        <name>quinine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15854</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929225</externalid>
        <name>aspartame zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>195544</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296382</externalid>
        <name>helicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29748</externalid>
        <name>maltose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17306</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296240</externalid>
        <name>3-hydroxyoctanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37098</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296456</externalid>
        <name>vitamin B1</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26948</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38937</externalid>
        <name>strychnine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40981</externalid>
        <name>parthenolide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7939</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296394</externalid>
        <name>(+)-cis-isohumulone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296406</externalid>
        <name>(-)-noscapine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31977</externalid>
        <name>melatonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16796</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>45240</externalid>
        <name>amarogentin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2622</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915908</externalid>
        <name>5-oxo-ETE(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>65342</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193005</externalid>
        <name>7alpha,25-dihydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44402</externalid>
        <name>artemorin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2853</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296448</externalid>
        <name>tatridin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73239</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296388</externalid>
        <name>limonin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16226</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44284</externalid>
        <name>absinthin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>44224</externalid>
        <name>yohimbine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>10093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296437</externalid>
        <name>Cascarillin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296458</externalid>
        <name>Quassin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>8692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9729060</externalid>
        <name>Cyclamate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82431</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444725</externalid>
        <name>D-tryptophan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16296</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296392</externalid>
        <name>cucurbitacin B</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3296418</externalid>
        <name>falcarindiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>69236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111885</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418594</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111885</externalid>
    <name>Opioid Signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111885</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>PPP2R5D</name>
        <entity>
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              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDYN</name>
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              <externalid>A0A3Q1MCT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADCY5</name>
        <entity>
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              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR2B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1B</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADCY4</name>
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              <externalid>A0A3Q1MA58</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNGT1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNB1</name>
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              <externalid>P62871</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PRKAR1B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OPRM1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N5B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PLA2G4A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP1CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNAI3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE4A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE1C</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319456</externalid>
        <name>PLCB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRK2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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            <xref>
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          </protein>
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      <gene>
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        <name>CAMKK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP1R1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07516</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNAQ</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CAMK4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GNAT3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>9729199</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9865249</externalid>
        <name>PDE4D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE4B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GNG10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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    <smallmolecules>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9760815</externalid>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-202040</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112040</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-180024</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111885</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418594</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202040</externalid>
    <name>G-protein activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202040</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319672</externalid>
        <name>OPRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319680</externalid>
        <name>PDYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202040</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111885</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112040</externalid>
    <name>G-protein mediated events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112040</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319456</externalid>
        <name>PLCB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-112043</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-170660</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-170670</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112040</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111885</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112043</externalid>
    <name>PLC beta mediated events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112043</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319456</externalid>
        <name>PLCB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111996</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112043</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112040</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111996</externalid>
    <name>Ca-dependent events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111996</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111995</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111997</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111996</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112043</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111995</externalid>
    <name>phospho-PLA2 pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111995</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319477</externalid>
        <name>PLA2G4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6814250</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58168</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915528</externalid>
        <name>1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75063</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111995</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111996</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111997</externalid>
    <name>CaM pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111997</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111933</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111997</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111996</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1489509</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111933</externalid>
    <name>Calmodulin induced events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111933</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-111931</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111932</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111957</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111933</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111997</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111931</externalid>
    <name>PKA-mediated phosphorylation of CREB</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111931</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-163615</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-111931</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111933</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163615</externalid>
    <name>PKA activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163615</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163615</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111931</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111932</externalid>
    <name>CaMK IV-mediated phosphorylation of CREB</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111932</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111932</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111933</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-111957</externalid>
    <name>Cam-PDE 1 activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-111957</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319608</externalid>
        <name>PDE1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319602</externalid>
        <name>PDE1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319596</externalid>
        <name>PDE1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14100</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-111957</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111933</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-170660</externalid>
    <name>Adenylate cyclase activating pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-170660</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-170660</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112040</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-170670</externalid>
    <name>Adenylate cyclase inhibitory pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-170670</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-170670</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112040</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-991365</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-180024</externalid>
    <name>DARPP-32 events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-180024</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326287</externalid>
        <name>CDK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326276</externalid>
        <name>PPP1CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325918</externalid>
        <name>PPP1R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07516</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9865249</externalid>
        <name>PDE4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319627</externalid>
        <name>PDE4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319631</externalid>
        <name>PDE4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325961</externalid>
        <name>PDE4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-180024</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-111885</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418597</externalid>
    <name>G alpha (z) signalling events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418597</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10407714</externalid>
        <name>RGS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46471</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407706</externalid>
        <name>RGS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407710</externalid>
        <name>RGS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79348</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339737</externalid>
        <name>GNAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MM27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337222</externalid>
        <name>ADRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-418597</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-416476</externalid>
    <name>G alpha (q) signalling events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-416476</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10407714</externalid>
        <name>RGS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46471</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336823</externalid>
        <name>TAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01289</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>OXTR</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>HCRT</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>MAPK7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ADRA1B</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>AVPR1A</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>DAGLA</name>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>DGKK</name>
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          <protein>
            <xref>
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    <smallmolecules>
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        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29574</externalid>
        <name>glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17754</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>417905</externalid>
        <name>1-octadec-9-enoylglycero-3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915674</externalid>
        <name>prostaglandin F2alpha(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444213</externalid>
        <name>hexanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17120</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444050</externalid>
        <name>valerate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31011</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760743</externalid>
        <name>L-dopa zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164338</externalid>
        <name>formate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15740</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760752</externalid>
        <name>L-ornithinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46911</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5694463</externalid>
        <name>3-arachidonoyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75571</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9916413</externalid>
        <name>lipoxin A4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419324</externalid>
        <name>2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52450</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317500</externalid>
        <name>leukotriene D4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63166</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915861</externalid>
        <name>leukotriene C4(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163521</externalid>
        <name>butyrate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17968</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915827</externalid>
        <name>leukotriene B4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57461</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915644</externalid>
        <name>prostaglandin E2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>606564</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760910</externalid>
        <name>histaminium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915904</externalid>
        <name>leukotriene E4(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57462</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316173</externalid>
        <name>photon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30212</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29664</externalid>
        <name>propionic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30768</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>419307</externalid>
        <name>2-arachidonoylglycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52392</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-114508</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-881907</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-416476</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-881907</externalid>
    <name>Gastrin-CREB signalling pathway via PKC and MAPK</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-881907</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336741</externalid>
        <name>CCKBR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T858</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337035</externalid>
        <name>GAST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01352</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2179392</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-881907</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-416476</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2179392</externalid>
    <name>EGFR Transactivation by Gastrin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2179392</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2179392</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-881907</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-416482</externalid>
    <name>G alpha (12/13) signalling events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-416482</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340921</externalid>
        <name>ARHGEF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340961</externalid>
        <name>FGD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320242</externalid>
        <name>GNA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340869</externalid>
        <name>RASGRF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340889</externalid>
        <name>MCF2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340997</externalid>
        <name>ARHGEF33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340901</externalid>
        <name>PLEKHG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340993</externalid>
        <name>ARHGEF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340989</externalid>
        <name>ARHGEF10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M851</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340977</externalid>
        <name>NGEF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341001</externalid>
        <name>ARHGEF37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340957</externalid>
        <name>FGD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340925</externalid>
        <name>ARHGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340929</externalid>
        <name>ARHGEF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335248</externalid>
        <name>PLXNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340873</externalid>
        <name>FGD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7I5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340949</externalid>
        <name>ARHGEF19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340885</externalid>
        <name>TIAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340856</externalid>
        <name>ROCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340897</externalid>
        <name>PLEKHG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340973</externalid>
        <name>NET1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340220</externalid>
        <name>ARHGEF25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340985</externalid>
        <name>ARHGEF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340941</externalid>
        <name>ARHGEF17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340981</externalid>
        <name>PREX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328377</externalid>
        <name>MCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Z3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340893</externalid>
        <name>ECT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336715</externalid>
        <name>TBXA2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95125</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320269</externalid>
        <name>GNA12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326451</externalid>
        <name>ARHGEF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340965</externalid>
        <name>FGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340913</externalid>
        <name>AKAP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340937</externalid>
        <name>ARHGEF16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340909</externalid>
        <name>ABR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339832</externalid>
        <name>ARHGEF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340905</externalid>
        <name>SOS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341005</externalid>
        <name>ARHGEF38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340371</externalid>
        <name>RHOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340933</externalid>
        <name>ARHGEF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340383</externalid>
        <name>ARHGEF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340216</externalid>
        <name>TRIO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336619</externalid>
        <name>ADRA1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336615</externalid>
        <name>ADRA1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340917</externalid>
        <name>ARHGEF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341009</externalid>
        <name>ARHGEF39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320248</externalid>
        <name>ARHGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LFQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336611</externalid>
        <name>ADRA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340945</externalid>
        <name>ARHGEF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340953</externalid>
        <name>ARHGEF26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340969</externalid>
        <name>ITSN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9915836</externalid>
        <name>thromboxane A2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57445</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-416482</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-397795</externalid>
    <name>G-protein beta:gamma signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-397795</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338945</externalid>
        <name>PIK3R6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340933</externalid>
        <name>ARHGEF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-392451</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418217</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964315</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8964616</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-397795</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388396</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392451</externalid>
    <name>G beta:gamma signalling through PI3Kgamma</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392451</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338945</externalid>
        <name>PIK3R6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-392451</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-397795</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-418217</externalid>
    <name>G beta:gamma signalling through PLC beta</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418217</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-418217</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-397795</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964315</externalid>
    <name>G beta:gamma signalling through BTK</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964315</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964315</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-397795</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8964616</externalid>
    <name>G beta:gamma signalling through CDC42</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8964616</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340933</externalid>
        <name>ARHGEF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8964616</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-397795</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-157118</externalid>
    <name>Signaling by NOTCH</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-157118</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360722</externalid>
        <name>DTX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409809</externalid>
        <name>ELF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360726</externalid>
        <name>DTX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331971</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E666</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360718</externalid>
        <name>DTX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1912422</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1980143</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013694</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-157118</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1912422</externalid>
    <name>Pre-NOTCH Expression and Processing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1912422</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409809</externalid>
        <name>ELF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331971</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E666</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1912408</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1912420</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1912422</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157118</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1912408</externalid>
    <name>Pre-NOTCH Transcription and Translation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1912408</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409809</externalid>
        <name>ELF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1912408</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1912422</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1912420</externalid>
    <name>Pre-NOTCH Processing in Golgi</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1912420</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331971</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E666</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1912420</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1912422</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1980143</externalid>
    <name>Signaling by NOTCH1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1980143</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360722</externalid>
        <name>DTX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360726</externalid>
        <name>DTX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360718</externalid>
        <name>DTX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2122948</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1980143</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157118</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2122948</externalid>
    <name>Activated NOTCH1 Transmits Signal to the Nucleus</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2122948</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360722</externalid>
        <name>DTX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360726</externalid>
        <name>DTX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360718</externalid>
        <name>DTX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2122948</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1980143</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9013694</externalid>
    <name>Signaling by NOTCH4</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013694</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9013700</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9013694</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157118</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9013700</externalid>
    <name>NOTCH4 Activation and Transmission of Signal to the Nucleus</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013700</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9013700</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013694</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-195721</externalid>
    <name>Signaling by WNT</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-195721</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371431</externalid>
        <name>TLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371059</externalid>
        <name>WNT10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312602</externalid>
        <name>KAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374140</externalid>
        <name>GNAO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08239</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337662</externalid>
        <name>CSNK1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328442</externalid>
        <name>AXIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M5FK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370969</externalid>
        <name>WLS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375170</externalid>
        <name>RSPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330709</externalid>
        <name>TCF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328501</externalid>
        <name>FRAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3238698</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195253</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3858494</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-195721</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3238698</externalid>
    <name>WNT ligand biogenesis and trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3238698</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10371037</externalid>
        <name>WNT2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6X8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371065</externalid>
        <name>WNT10B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370963</externalid>
        <name>VPS35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371047</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370959</externalid>
        <name>VPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0M0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371025</externalid>
        <name>WNT7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371019</externalid>
        <name>WNT7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330619</externalid>
        <name>WNT8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371059</externalid>
        <name>WNT10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371071</externalid>
        <name>WNT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371077</externalid>
        <name>WNT16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370973</externalid>
        <name>SNX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371031</externalid>
        <name>WNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4D7S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371053</externalid>
        <name>WNT9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370995</externalid>
        <name>WNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370955</externalid>
        <name>VPS26A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370969</externalid>
        <name>WLS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370987</externalid>
        <name>WNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330607</externalid>
        <name>WNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371125</externalid>
        <name>TMED5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330625</externalid>
        <name>WNT8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371007</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330613</externalid>
        <name>WNT3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371013</externalid>
        <name>WNT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3238698</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195721</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-195253</externalid>
    <name>Degradation of beta-catenin by the destruction complex</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-195253</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>ADRM1</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CTNNB1</name>
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        <name>AMER1</name>
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      <gene>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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    </smallmolecules>
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        <externalid>R-BTA-196299</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4641265</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-195253</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195721</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
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  </biosystem>
  <biosystem>
    <externalid>R-BTA-196299</externalid>
    <name>Beta-catenin phosphorylation cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196299</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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              <externalid>E1BNA0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
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              <externalid>Q0P594</externalid>
            </xref>
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      <gene>
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        <name>PPP2R5C</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AXIN1</name>
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          <protein>
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              <externalid>M5FK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R5D</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CA</name>
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          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GSK3B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>APC</name>
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          <protein>
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              <externalid>F1MV51</externalid>
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          </protein>
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      <gene>
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        <name>FRAT2</name>
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          <protein>
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              <externalid>G3N174</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTNNB1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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    </genes>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196299</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195253</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4641265</externalid>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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    </genes>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <taxnode>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-201688</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4641262</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201722</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3769402</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4641258</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4641257</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4641263</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3772470</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-201681</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195721</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-201688</externalid>
    <name>WNT mediated activation of DVL</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-201688</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330635</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337662</externalid>
        <name>CSNK1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330645</externalid>
        <name>DVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359284</externalid>
        <name>PIP5K1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-201688</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4641262</externalid>
    <name>Disassembly of the destruction complex and recruitment of AXIN to the membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4641262</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328505</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330635</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330597</externalid>
        <name>FZD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330601</externalid>
        <name>FZD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330645</externalid>
        <name>DVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330619</externalid>
        <name>WNT8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330587</externalid>
        <name>LRP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321242</externalid>
        <name>PPP2R5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321250</externalid>
        <name>PPP2R5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330809</externalid>
        <name>CAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330591</externalid>
        <name>LRP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328442</externalid>
        <name>AXIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M5FK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330607</externalid>
        <name>WNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328454</externalid>
        <name>APC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328446</externalid>
        <name>AMER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328501</externalid>
        <name>FRAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321238</externalid>
        <name>PPP2R5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330625</externalid>
        <name>WNT8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330613</externalid>
        <name>WNT3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4641262</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-201722</externalid>
    <name>Formation of the beta-catenin:TCF transactivating complex</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-201722</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322459</externalid>
        <name>TERT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371431</externalid>
        <name>TLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366516</externalid>
        <name>MEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312602</externalid>
        <name>KAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372057</externalid>
        <name>RBBP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319945</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
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          </protein>
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      <gene>
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        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371425</externalid>
        <name>TLE3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380864</externalid>
        <name>SOX17</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373088</externalid>
        <name>CBY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8MJK1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380852</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382514</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371419</externalid>
        <name>TLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJY1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378461</externalid>
        <name>CHD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10328454</externalid>
        <name>APC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371413</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3769402</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
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      <gene>
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        <name>PSMD6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10330645</externalid>
        <name>DVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMW6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMA3</name>
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              <externalid>Q58DU5</externalid>
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          </protein>
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      <gene>
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        <name>DVL2</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>Q32KL2</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>DACT1</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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    </genes>
    <linkedsystems>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
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    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4641257</externalid>
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4641257</url>
    <taxonomy>
      <taxnode>
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    </taxonomy>
    <genes>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC2</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RNF146B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T139</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372437</externalid>
        <name>AXIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328442</externalid>
        <name>AXIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M5FK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372448</externalid>
        <name>TNKS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372444</externalid>
        <name>TNKS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMY0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4641257</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4641263</externalid>
    <name>Regulation of FZD by ubiquitination</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4641263</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375219</externalid>
        <name>FZD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
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            <xref>
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              <externalid>F1MLJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375178</externalid>
        <name>RSPO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330591</externalid>
        <name>LRP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375166</externalid>
        <name>LGR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355304</externalid>
        <name>USP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LRP6</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MDE1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375182</externalid>
        <name>RSPO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375170</externalid>
        <name>RSPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373615</externalid>
        <name>FZD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375174</externalid>
        <name>RSPO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RLD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375194</externalid>
        <name>RNF43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330613</externalid>
        <name>WNT3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375190</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4641263</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3772470</externalid>
    <name>Negative regulation of TCF-dependent signaling by WNT ligand antagonists</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3772470</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>LRP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330591</externalid>
        <name>LRP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373120</externalid>
        <name>SOST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3772470</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-201681</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3858494</externalid>
    <name>Beta-catenin independent WNT signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3858494</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74037</externalid>
        <name>PDE6G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
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        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375866</externalid>
        <name>ROR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374140</externalid>
        <name>GNAO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08239</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373607</externalid>
        <name>FZD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-4086400</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4086398</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-3858494</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195721</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4086400</externalid>
    <name>PCP/CE pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4086400</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371071</externalid>
        <name>WNT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330330</externalid>
        <name>SMURF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370995</externalid>
        <name>WNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327166</externalid>
        <name>CLTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373631</externalid>
        <name>DAAM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LHF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341085</externalid>
        <name>PARD6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RHP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371007</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330635</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331559</externalid>
        <name>PFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02584</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330597</externalid>
        <name>FZD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330601</externalid>
        <name>FZD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330645</externalid>
        <name>DVL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375866</externalid>
        <name>ROR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373615</externalid>
        <name>FZD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373611</externalid>
        <name>FZD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373607</externalid>
        <name>FZD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375059</externalid>
        <name>PRICKLE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375219</externalid>
        <name>FZD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330607</externalid>
        <name>WNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375862</externalid>
        <name>ROR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-4608870</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5099900</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5140745</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-4086400</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3858494</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4608870</externalid>
    <name>Asymmetric localization of PCP proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4608870</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330597</externalid>
        <name>FZD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330601</externalid>
        <name>FZD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330330</externalid>
        <name>SMURF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373611</externalid>
        <name>FZD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373607</externalid>
        <name>FZD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375219</externalid>
        <name>FZD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375059</externalid>
        <name>PRICKLE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341085</externalid>
        <name>PARD6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RHP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4608870</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4086400</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5099900</externalid>
    <name>WNT5A-dependent internalization of FZD4</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5099900</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327166</externalid>
        <name>CLTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5099900</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4086400</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5140745</externalid>
    <name>WNT5A-dependent internalization of FZD2, FZD5 and ROR2</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5140745</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327166</externalid>
        <name>CLTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330601</externalid>
        <name>FZD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375866</externalid>
        <name>ROR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375862</externalid>
        <name>ROR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5140745</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4086400</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4086398</externalid>
    <name>Ca2+ pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4086398</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10374722</externalid>
        <name>NLK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>H2XJE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341224</externalid>
        <name>GNAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04696</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330601</externalid>
        <name>FZD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330705</externalid>
        <name>LEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371001</externalid>
        <name>WNT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363600</externalid>
        <name>NFATC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74037</externalid>
        <name>PDE6G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04972</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373615</externalid>
        <name>FZD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371071</externalid>
        <name>WNT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374140</externalid>
        <name>GNAO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08239</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373611</externalid>
        <name>FZD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363589</externalid>
        <name>PPP3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316276</externalid>
        <name>PDE6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374130</externalid>
        <name>FZD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316280</externalid>
        <name>PDE6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4086398</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3858494</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2028269</externalid>
    <name>Signaling by Hippo</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2028269</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10363718</externalid>
        <name>LATS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363761</externalid>
        <name>AMOTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334526</externalid>
        <name>TJP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363728</externalid>
        <name>MOB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363676</externalid>
        <name>STK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354661</externalid>
        <name>YAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363774</externalid>
        <name>STK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363670</externalid>
        <name>SAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6E1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330640</externalid>
        <name>DVL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363722</externalid>
        <name>LATS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364396</externalid>
        <name>NPHP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364162</externalid>
        <name>WWC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363765</externalid>
        <name>AMOTL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363818</externalid>
        <name>WWTR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363757</externalid>
        <name>AMOT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2028269</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5358351</externalid>
    <name>Signaling by Hedgehog</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5358351</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343882</externalid>
        <name>HHIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335613</externalid>
        <name>CDON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379497</externalid>
        <name>IFT122</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381097</externalid>
        <name>IQCE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337747</externalid>
        <name>OFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378424</externalid>
        <name>SCUBE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378310</externalid>
        <name>SEL1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379665</externalid>
        <name>INTU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343890</externalid>
        <name>DHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352435</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381107</externalid>
        <name>EVC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BES3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379549</externalid>
        <name>NUMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379479</externalid>
        <name>GLI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335609</externalid>
        <name>BOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379442</externalid>
        <name>GLI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N215</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378159</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379612</externalid>
        <name>SMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114736</externalid>
        <name>phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5358346</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5610787</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5632684</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5358351</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5358346</externalid>
    <name>Hedgehog ligand biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5358346</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378314</externalid>
        <name>DERL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378292</externalid>
        <name>ERLEC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378296</externalid>
        <name>OS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378304</externalid>
        <name>SYVN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343886</externalid>
        <name>SHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378418</externalid>
        <name>DISP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343894</externalid>
        <name>IHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378310</externalid>
        <name>SEL1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378424</externalid>
        <name>SCUBE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343890</externalid>
        <name>DHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378444</externalid>
        <name>NOTUM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378159</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114736</externalid>
        <name>phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5362798</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5358346</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5358351</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5362798</externalid>
    <name>Release of Hh-Np from the secreting cell</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5362798</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359206</externalid>
        <name>GPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343886</externalid>
        <name>SHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378444</externalid>
        <name>NOTUM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378418</externalid>
        <name>DISP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378424</externalid>
        <name>SCUBE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343894</externalid>
        <name>IHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343890</externalid>
        <name>DHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5362798</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5358346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5610787</externalid>
    <name>Hedgehog 'off' state</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5610787</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379661</externalid>
        <name>FUZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379511</externalid>
        <name>TTC21B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379446</externalid>
        <name>SUFU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379515</externalid>
        <name>WDR35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379505</externalid>
        <name>IFT140</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B860</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379475</externalid>
        <name>GLI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379501</externalid>
        <name>WDR19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379649</externalid>
        <name>RPGRIP1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379653</externalid>
        <name>MKS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RVK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379523</externalid>
        <name>TULP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379676</externalid>
        <name>IFT88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379497</externalid>
        <name>IFT122</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337747</externalid>
        <name>OFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379680</externalid>
        <name>IFT52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379622</externalid>
        <name>PTCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379684</externalid>
        <name>IFT57</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379665</externalid>
        <name>INTU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352435</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379493</externalid>
        <name>GPR161</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379549</externalid>
        <name>NUMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379479</externalid>
        <name>GLI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379442</externalid>
        <name>GLI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N215</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379612</externalid>
        <name>SMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5610785</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5610780</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5610787</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5358351</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5610785</externalid>
    <name>GLI3 is processed to GLI3R by the proteasome</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5610785</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379446</externalid>
        <name>SUFU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379442</externalid>
        <name>GLI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N215</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5610785</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5610787</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5610780</externalid>
    <name>Degradation of GLI1 by the proteasome</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5610780</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379446</externalid>
        <name>SUFU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>NUMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>Q2KJ25</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>GLI1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6H727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
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              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5610780</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5632684</externalid>
    <name>Hedgehog 'on' state</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5632684</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>HHIP</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PJW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347028</externalid>
        <name>ITCH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381021</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DZIP1</name>
        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381170</externalid>
        <name>ULK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N332</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330330</externalid>
        <name>SMURF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381043</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343886</externalid>
        <name>SHH</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381093</externalid>
        <name>EFCAB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379446</externalid>
        <name>SUFU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343894</externalid>
        <name>IHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381222</externalid>
        <name>SPOP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379475</externalid>
        <name>GLI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319937</externalid>
        <name>CDC73</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21146</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381263</externalid>
        <name>KIF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335613</externalid>
        <name>CDON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381097</externalid>
        <name>IQCE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379622</externalid>
        <name>PTCH1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1D5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381228</externalid>
        <name>SPOPL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAL9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343890</externalid>
        <name>DHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352435</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381107</externalid>
        <name>EVC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BES3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379493</externalid>
        <name>GPR161</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351922</externalid>
        <name>CUL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379549</externalid>
        <name>NUMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324768</externalid>
        <name>SMURF2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381103</externalid>
        <name>EVC</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MQQ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
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              <externalid>G3X811</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379479</externalid>
        <name>GLI2</name>
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              <externalid>F1MCY1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335609</externalid>
        <name>BOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379442</externalid>
        <name>GLI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N215</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379612</externalid>
        <name>SMO</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5632681</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5635838</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5632684</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5358351</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5632681</externalid>
    <name>Ligand-receptor interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5632681</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335613</externalid>
        <name>CDON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343882</externalid>
        <name>HHIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343886</externalid>
        <name>SHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379622</externalid>
        <name>PTCH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
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      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
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      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024379</externalid>
        <name>(22R)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9632066</externalid>
        <name>estetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024327</externalid>
        <name>24(S),25-epoxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5362558</externalid>
        <name>9-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36981</externalid>
        <name>estriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5362517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8939211</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9024446</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9006931</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5362517</externalid>
    <name>Signaling by Retinoic Acid</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5362517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>FABP5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P55052</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC132342089</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331757</externalid>
        <name>PDHB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P11966</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378485</externalid>
        <name>DHRS4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MZD5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RARG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DD4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335918</externalid>
        <name>RARB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3X6X1</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>P52898</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RXRA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ALDH1A1</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RDH5</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q27979</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335906</externalid>
        <name>RXRB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RXRG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VC20</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RDH16</name>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F1MFZ4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DLAT</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N690</externalid>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T874</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CYP26C1</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>PDK2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>DHRS3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N334</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ALDH1A3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378407</externalid>
        <name>CRABP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62964</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335914</externalid>
        <name>RARA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWQ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377854</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX32</externalid>
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          </protein>
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      <gene>
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        <name>PDK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG3</externalid>
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          </protein>
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      <gene>
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        <name>DLD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
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          </protein>
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      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDHX</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22439</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333252</externalid>
        <name>CYP26B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ALDH1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6U1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378381</externalid>
        <name>SDR16C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFD4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RDH13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378489</externalid>
        <name>RDH14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QW3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDK4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDHA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Y3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PDK1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DHRS9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYR6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDHA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPARD</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4IFL4</externalid>
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          </protein>
        </entity>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9638947</externalid>
        <name>thiamine(1+) diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58937</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5362558</externalid>
        <name>9-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5365859</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5362517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006931</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5365859</externalid>
    <name>RA biosynthesis pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5365859</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368137</externalid>
        <name>DHRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N334</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378396</externalid>
        <name>ALDH1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378407</externalid>
        <name>CRABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378485</externalid>
        <name>DHRS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333252</externalid>
        <name>CYP26B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314195</externalid>
        <name>ALDH1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367994</externalid>
        <name>RDH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27979</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378390</externalid>
        <name>ALDH1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378381</externalid>
        <name>SDR16C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380248</externalid>
        <name>RDH13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378489</externalid>
        <name>RDH14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367998</externalid>
        <name>RDH16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314212</externalid>
        <name>ADH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368010</externalid>
        <name>DHRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HYR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316773</externalid>
        <name>RDH10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387902</externalid>
        <name>ALDH8A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T874</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316777</externalid>
        <name>RDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333172</externalid>
        <name>CYP26C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333248</externalid>
        <name>CYP26A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114842</externalid>
        <name>all-trans-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5362558</externalid>
        <name>9-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114828</externalid>
        <name>all-trans-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17898</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114863</externalid>
        <name>11-cis-retinol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16302</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114884</externalid>
        <name>11-cis-retinal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327964</externalid>
        <name>all-trans-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327962</externalid>
        <name>9-cis-4-hydroxyretinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>63802</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5365859</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5362517</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8939211</externalid>
    <name>ESR-mediated signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8939211</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321272</externalid>
        <name>XPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319829</externalid>
        <name>CCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6T8E9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365643</externalid>
        <name>PRKCZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNH7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335970</externalid>
        <name>NR5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335850</externalid>
        <name>PGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340168</externalid>
        <name>CARM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329755</externalid>
        <name>FOXO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31001</externalid>
        <name>17beta-estradiol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16469</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30201</externalid>
        <name>estrone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9632066</externalid>
        <name>estetrol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>142773</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36981</externalid>
        <name>estriol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27974</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9018519</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9009391</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8939211</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006931</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9018519</externalid>
    <name>Estrogen-dependent gene expression</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9018519</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319829</externalid>
        <name>CCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6T8E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335970</externalid>
        <name>NR5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335850</externalid>
        <name>PGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340168</externalid>
        <name>CARM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410444</externalid>
        <name>GREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8U3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312602</externalid>
        <name>KAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323870</externalid>
        <name>JUN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409912</externalid>
        <name>USF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366585</externalid>
        <name>SP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373693</externalid>
        <name>DDX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M155</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333434</externalid>
        <name>MED1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352902</externalid>
        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374414</externalid>
        <name>NRIP1</name>
        <entity>
          <protein>
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  <biosystem>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9839008</externalid>
        <name>N(omega),N(omega)-dimethyl-L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58326</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760982</externalid>
        <name>sphingosine 1-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60119</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841166</externalid>
        <name>sphingoid base(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>84410</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9634635</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9634638</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9009391</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8939211</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9634635</externalid>
    <name>Estrogen-stimulated signaling through PRKCZ</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9634635</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365643</externalid>
        <name>PRKCZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9634635</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9009391</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9634638</externalid>
    <name>Estrogen-dependent nuclear events downstream of ESR-membrane signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9634638</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321272</externalid>
        <name>XPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329755</externalid>
        <name>FOXO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411385</externalid>
        <name>UHMK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9634638</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9009391</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9024446</externalid>
    <name>NR1H2 and NR1H3-mediated signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9024446</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335830</externalid>
        <name>NR1H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335950</externalid>
        <name>NR1H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333727</externalid>
        <name>ABCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373256</externalid>
        <name>GPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335906</externalid>
        <name>RXRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334280</externalid>
        <name>TBL1X</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B7TCI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334284</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024379</externalid>
        <name>(22R)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024327</externalid>
        <name>24(S),25-epoxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41633</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9029569</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9623433</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9024446</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006931</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9029569</externalid>
    <name>NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9029569</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335830</externalid>
        <name>NR1H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335950</externalid>
        <name>NR1H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333727</externalid>
        <name>ABCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373256</externalid>
        <name>GPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335906</externalid>
        <name>RXRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334280</externalid>
        <name>TBL1X</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B7TCI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334284</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024379</externalid>
        <name>(22R)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024327</externalid>
        <name>24(S),25-epoxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41633</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9029569</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9024446</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9623433</externalid>
    <name>NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9623433</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335830</externalid>
        <name>NR1H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335950</externalid>
        <name>NR1H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327611</externalid>
        <name>NCOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335906</externalid>
        <name>RXRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024379</externalid>
        <name>(22R)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67237</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024333</externalid>
        <name>(25R)-cholest-5-ene-3beta,26-diol</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>76591</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9024327</externalid>
        <name>24(S),25-epoxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41633</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9623433</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9024446</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5683057</externalid>
    <name>MAPK family signaling cascades</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5683057</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383325</externalid>
        <name>GFRA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383557</externalid>
        <name>DUSP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPN11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP2K1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387048</externalid>
        <name>CDC14B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5B2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
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          <protein>
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              <externalid>A4FUZ3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CAMK2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CSF2</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>IL6R</name>
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          <protein>
            <xref>
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              <externalid>E1BJQ3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CDK1</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>PPP2CA</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>A2VDZ0</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>MAPK6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E577</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ABHD17A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDE6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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          <protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EGFR</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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          <protein>
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              <externalid>E1BFB0</externalid>
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          </protein>
        </entity>
      </gene>
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        <name>UBB</name>
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              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IL6</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P26892</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMC4</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GOLGA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NRG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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          </protein>
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      <gene>
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        <name>FRS2</name>
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      <gene>
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        <name>GFRA3</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>IL5RA</name>
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      <gene>
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      <gene>
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        <name>KL</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PTPRA</name>
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          </protein>
        </entity>
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      <gene>
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        <name>PDGFA</name>
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          </protein>
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      </gene>
      <gene>
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        <name>KITLG</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DLG3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP16</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAA9</externalid>
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          </protein>
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      <gene>
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        <name>FGF5</name>
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      <gene>
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        <name>IL2</name>
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      <gene>
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      <gene>
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        <name>CDC14A</name>
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      <gene>
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      <gene>
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        <name>ETV4</name>
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      <gene>
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        <name>PIK3CB</name>
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          </protein>
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      <gene>
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        <name>AREG</name>
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      <gene>
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        <name>RASGRP1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FGF20</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>JAK1</name>
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            <xref>
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              <externalid>F1N0D6</externalid>
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          </protein>
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      <gene>
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        <name>PDGFRA</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX49</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383270</externalid>
        <name>RASGRP4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJB1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCL0</externalid>
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          </protein>
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      <gene>
        <externalid>10383305</externalid>
        <name>NRTN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKU1</externalid>
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          </protein>
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      <gene>
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        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>LYPLA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
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          </protein>
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      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>EPGN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IL2RG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10339682</externalid>
        <name>SPTA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMQ8</externalid>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>GDNF</name>
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      <gene>
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        <name>FGF7</name>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-5684996</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5687128</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5683057</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>MAPK1/MAPK3 signaling</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5684996</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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        <name>PPP2R5D</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
        </entity>
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          </protein>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5673001</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112409</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5684996</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5683057</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5673001</externalid>
    <name>RAF/MAP kinase cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5673001</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383325</externalid>
        <name>GFRA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383557</externalid>
        <name>DUSP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381770</externalid>
        <name>FRS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318676</externalid>
        <name>FGFR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316453</externalid>
        <name>IRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345604</externalid>
        <name>CSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11052</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383573</externalid>
        <name>DUSP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383411</externalid>
        <name>CNKSR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N773</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383236</externalid>
        <name>RASGRF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326042</externalid>
        <name>TGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383403</externalid>
        <name>KSR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383535</externalid>
        <name>PEA15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321238</externalid>
        <name>PPP2R5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411982</externalid>
        <name>ABHD17A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380534</externalid>
        <name>PDE6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95142</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377329</externalid>
        <name>ARL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318760</externalid>
        <name>FGFR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383253</externalid>
        <name>SHC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331533</externalid>
        <name>SPTAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391682</externalid>
        <name>GOLGA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354024</externalid>
        <name>NRG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411971</externalid>
        <name>ZDHHC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354381</externalid>
        <name>ERBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318623</externalid>
        <name>FGF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344940</externalid>
        <name>IL3RA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LK34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383484</externalid>
        <name>MORG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383349</externalid>
        <name>RANBP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332263</externalid>
        <name>ANGPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18920</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383166</externalid>
        <name>ARAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383188</externalid>
        <name>PHB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T165</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383431</externalid>
        <name>PEBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13696</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321242</externalid>
        <name>PPP2R5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334740</externalid>
        <name>APBB1IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM0</externalid>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9648002</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5673000</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5674135</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5675221</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5673001</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5684996</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9648002</externalid>
    <name>RAS processing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9648002</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10389886</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411971</externalid>
        <name>ZDHHC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411982</externalid>
        <name>ABHD17A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388151</externalid>
        <name>RCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340622</externalid>
        <name>PRKG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380534</externalid>
        <name>PDE6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95142</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388170</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MME1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377329</externalid>
        <name>ARL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330569</externalid>
        <name>FNTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N081</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411986</externalid>
        <name>FAM108B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368548</externalid>
        <name>FNTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49355</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331624</externalid>
        <name>LYPLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388166</externalid>
        <name>LOC112446467</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411990</externalid>
        <name>ABHD17C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391682</externalid>
        <name>GOLGA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9648002</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5673001</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5673000</externalid>
    <name>RAF activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5673000</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383374</externalid>
        <name>MAP3K11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412186</externalid>
        <name>SHOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383368</externalid>
        <name>BRAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H716</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383166</externalid>
        <name>ARAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383188</externalid>
        <name>PHB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T165</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321242</externalid>
        <name>PPP2R5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MARK3</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LWF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321280</externalid>
        <name>PPP1CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61287</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412190</externalid>
        <name>MRAS</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5D7L6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321250</externalid>
        <name>PPP2R5C</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R5A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>KSR1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>PPP1CB</name>
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          <protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-5673000</externalid>
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          <linked />
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      <linkedsystem>
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  <biosystem>
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    <name>MAP2K and MAPK activation</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5674135</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>E1BIM8</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MTN1</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MGZ4</externalid>
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          </protein>
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      <gene>
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              <externalid>F1N773</externalid>
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      <gene>
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              <externalid>Q3MHM0</externalid>
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      <gene>
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              <externalid>A0A140T894</externalid>
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      <gene>
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        <name>LAMTOR3</name>
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              <externalid>Q17QQ1</externalid>
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      <gene>
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        <name>VWF</name>
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              <externalid>A0A3Q1LLU1</externalid>
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      <gene>
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              <externalid>P46196</externalid>
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              <externalid>P62833</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>A0A3Q1MN97</externalid>
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      <gene>
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      <gene>
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              <externalid>G3MXH2</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>FN1</name>
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              <externalid>G5E5A9</externalid>
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          </protein>
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      </gene>
    </genes>
    <smallmolecules>
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        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>magnesium(2+)</name>
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          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>calcium(2+)</name>
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          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5674135</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5673001</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5675221</externalid>
    <name>Negative regulation of MAPK pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5675221</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383596</externalid>
        <name>DUSP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344691</externalid>
        <name>MAPK12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383368</externalid>
        <name>BRAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H716</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383557</externalid>
        <name>DUSP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383623</externalid>
        <name>PPP5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N719</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383166</externalid>
        <name>ARAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383573</externalid>
        <name>DUSP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321242</externalid>
        <name>PPP2R5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383431</externalid>
        <name>PEBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13696</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383147</externalid>
        <name>MARK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383565</externalid>
        <name>DUSP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321250</externalid>
        <name>PPP2R5C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383561</externalid>
        <name>DUSP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383569</externalid>
        <name>DUSP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383506</externalid>
        <name>PAQR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411454</externalid>
        <name>PTPN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321238</externalid>
        <name>PPP2R5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383577</externalid>
        <name>DUSP16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383143</externalid>
        <name>KSR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401250</externalid>
        <name>PTPN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5674499</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5675221</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5673001</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5674499</externalid>
    <name>Negative feedback regulation of MAPK pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5674499</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10354738</externalid>
        <name>BRAF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M353</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5674499</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5675221</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112409</externalid>
    <name>RAF-independent MAPK1/3 activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112409</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383565</externalid>
        <name>DUSP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318926</externalid>
        <name>IL6R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383596</externalid>
        <name>DUSP9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318951</externalid>
        <name>TYK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383561</externalid>
        <name>DUSP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383569</externalid>
        <name>DUSP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383557</externalid>
        <name>DUSP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318922</externalid>
        <name>IL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26892</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383535</externalid>
        <name>PEA15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318941</externalid>
        <name>JAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318932</externalid>
        <name>IL6ST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383577</externalid>
        <name>DUSP16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383573</externalid>
        <name>DUSP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-110056</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112409</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5684996</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-110056</externalid>
    <name>MAPK3 (ERK1) activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-110056</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10318922</externalid>
        <name>IL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26892</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318914</externalid>
        <name>MAP2K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318926</externalid>
        <name>IL6R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318951</externalid>
        <name>TYK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318941</externalid>
        <name>JAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318932</externalid>
        <name>IL6ST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-110056</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112409</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5687128</externalid>
    <name>MAPK6/MAPK4 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5687128</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>XPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370822</externalid>
        <name>MAPKAPK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329755</externalid>
        <name>FOXO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312415</externalid>
        <name>CCND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387048</externalid>
        <name>CDC14B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345254</externalid>
        <name>HSPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T149</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385183</externalid>
        <name>NCOA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329751</externalid>
        <name>FOXO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385154</externalid>
        <name>MAPK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E577</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325113</externalid>
        <name>CDC14A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385211</externalid>
        <name>ETV4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372262</externalid>
        <name>DNAJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
            </xref>
          </protein>
        </entity>
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          </protein>
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      <gene>
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        <name>RNF146B</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PIP5K1B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N7M1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AREG</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MEV4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FGF20</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PDGFRA</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IRS2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>RPTOR</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MYD88</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD12</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>EPGN</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>TRAF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMD11</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FGF7</name>
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              <sourcename>UniProt</sourcename>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1,2-diacyl-sn-glycerol</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9760921</externalid>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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        <name>water</name>
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      <smallmolecule>
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      <smallmolecule>
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        <name>estrogen</name>
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          <externalid>50114</externalid>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
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      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-HSA-9006925</externalid>
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        <externalid>R-BTA-162582</externalid>
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    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
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      <gene>
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        <name>PPP2CB</name>
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              <externalid>Q0P594</externalid>
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      <gene>
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        <name>PSMA6</name>
        <entity>
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              <externalid>Q2YDE4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SLC38A9</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IL1RL1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MRU1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PHC3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBA7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDGFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ15</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332406</externalid>
        <name>KITLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352062</externalid>
        <name>MKRN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF12</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318615</externalid>
        <name>FGF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0MTF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359293</externalid>
        <name>PIP4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGY3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF17</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372430</externalid>
        <name>RNF146B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T139</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIP5K1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7M1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AREG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF20</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP37</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDGFRA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPTOR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG06</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF23</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PIP5K1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>TRAF6</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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        <name>heparan sulfate</name>
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      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
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      <smallmolecule>
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        <name>nicotinamide</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <externalid>15377</externalid>
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      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
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          <externalid>50114</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-9006925</externalid>
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  <biosystem>
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    <name>Negative regulation of the PI3K/AKT network</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-199418</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>F1N1S8</externalid>
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      <gene>
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              <externalid>Q9TU25</externalid>
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      <gene>
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        <name>FGFR2</name>
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          </protein>
        </entity>
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      <gene>
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        <name>IRS1</name>
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              <externalid>F1MYE0</externalid>
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      <gene>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>FGF22</name>
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              <externalid>F1MQA1</externalid>
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          </protein>
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      <gene>
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        <name>PPP2R1A</name>
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              <externalid>A5D973</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A2VDZ0</externalid>
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        <name>KLB</name>
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              <externalid>F1N4S9</externalid>
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          </protein>
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      <gene>
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        <name>CD19</name>
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              <externalid>F1N586</externalid>
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      <gene>
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        <name>FGF1</name>
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              <externalid>P03968</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
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              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGF18</name>
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              <externalid>F2Z4J0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>IRAK1</name>
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              <externalid>Q2LGB3</externalid>
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          </protein>
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      <gene>
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        <name>NTRK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335866</externalid>
        <name>ESR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359280</externalid>
        <name>PIP5K1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318611</externalid>
        <name>Fgf4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XGD3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326050</externalid>
        <name>EPGN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340236</externalid>
        <name>MET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Z4YHD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
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      <gene>
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        <name>FGF7</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6811558</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-199418</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1257604</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-6811558</externalid>
    <name>PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6811558</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>PIP4K2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT2</externalid>
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          </protein>
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      <gene>
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        <name>MAPK3</name>
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          <protein>
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              <externalid>E1B8P9</externalid>
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          </protein>
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      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
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              <externalid>A2VE27</externalid>
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          </protein>
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      <gene>
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        <name>PPP2R5D</name>
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          <protein>
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              <externalid>F1N1S8</externalid>
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          </protein>
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      <gene>
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        <name>GRB2</name>
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          <protein>
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              <externalid>Q3T0F9</externalid>
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          </protein>
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      <gene>
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        <name>FGF9</name>
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      <gene>
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        <name>PTPN11</name>
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              <externalid>F1N339</externalid>
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          </protein>
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      <gene>
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        <name>RAC2</name>
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              <externalid>Q9TU25</externalid>
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      <gene>
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        <name>FGFR2</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MQA1</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CD80</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>IRAK1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>NTRK3</name>
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          </protein>
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      <gene>
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      <gene>
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        <name>FGFR4</name>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>BDNF</name>
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          </protein>
        </entity>
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      <gene>
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        <name>KIT</name>
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          </protein>
        </entity>
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      <gene>
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        <name>NRG1</name>
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          </protein>
        </entity>
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      <gene>
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        <name>PIK3CA</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>ERBB4</name>
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          </protein>
        </entity>
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      <gene>
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        <name>EGFR</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIP5K1C</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD28</name>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1BE66</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FGFR3</name>
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          </protein>
        </entity>
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      <gene>
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              <externalid>A0JNB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INS</name>
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              <externalid>A5PJB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318619</externalid>
        <name>FGF6</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>SRC</name>
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          </protein>
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      <gene>
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        <name>ICOS</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>TRAT1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>RHOG</name>
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          </protein>
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      </gene>
      <gene>
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        <name>IER3</name>
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          </protein>
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      </gene>
      <gene>
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        <name>KL</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IL33</name>
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          </protein>
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      </gene>
      <gene>
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        <name>INSR</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NTF3</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>FGFR1</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <name>NTF4</name>
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          </protein>
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      </gene>
      <gene>
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        <name>ESR2</name>
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          </protein>
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      <gene>
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        <name>FLT3</name>
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      <gene>
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        <name>IL1RL1</name>
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          </protein>
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      <gene>
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        <name>PDGFA</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>FGF5</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IRAK4</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>IL1RAP</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>AREG</name>
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      <gene>
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        <name>NTRK2</name>
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          </protein>
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      <gene>
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      <gene>
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        <name>PDGFRA</name>
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      <gene>
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        <name>IRS2</name>
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              <externalid>F1MJE0</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>MYD88</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1666990</externalid>
        <name>heparan sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28815</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6811558</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199418</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6807070</externalid>
    <name>PTEN Regulation</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6807070</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>SALL4</name>
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              <externalid>E1BJZ5</externalid>
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      <gene>
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        <name>PSMC2</name>
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              <externalid>Q5E9F9</externalid>
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          </protein>
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      <gene>
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        <name>PSMC3</name>
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              <externalid>F1MWE0</externalid>
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      <gene>
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            </xref>
          </protein>
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        <name>PSMD7</name>
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          </protein>
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            </xref>
          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      <gene>
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        <name>PSMB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>HDAC1</name>
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          </protein>
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      <gene>
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              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>OTUD3</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>STUB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>nicotinamide</name>
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      <linkedsystem>
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        <externalid>R-BTA-1257604</externalid>
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    <name>Regulation of PTEN gene transcription</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8943724</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>A8E4N5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RRAGC</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MTOR</name>
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              <externalid>E1BFB4</externalid>
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      </gene>
      <gene>
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              <externalid>G5E5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8943724</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807070</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8948747</externalid>
    <name>Regulation of PTEN localization</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329812</externalid>
        <name>PTEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370516</externalid>
        <name>USP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N556</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370057</externalid>
        <name>PML</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351738</externalid>
        <name>NEDD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8948747</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807070</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Regulation of PTEN stability and activity</name>
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    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
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      </taxnode>
    </taxonomy>
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        <externalid>10311769</externalid>
        <name>PSMD6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>F1MJ10</externalid>
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          </protein>
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      <gene>
        <externalid>10311723</externalid>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68399</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388755</externalid>
        <name>USP13</name>
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          </protein>
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      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
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      <gene>
        <externalid>10398918</externalid>
        <name>PREX2</name>
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          <protein>
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              <externalid>E1BDL7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
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      <gene>
        <externalid>218119</externalid>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WWP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
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          </protein>
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      <gene>
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        <name>MKRN1</name>
        <entity>
          <protein>
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              <externalid>F1MF12</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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              <externalid>Q3ZBG0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>TNKS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMY0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PSMB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>TRIM27</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RNF146B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T139</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA3</name>
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          <protein>
            <xref>
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              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329812</externalid>
        <name>PTEN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>OTUD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>A7MBA2</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1BPI3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>Q3ZCK9</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>P0CG53</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STUB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1B8R5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8948751</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807070</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>ADCY4</name>
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      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADCY2</name>
        <entity>
          <protein>
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              <externalid>F1MJV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319643</externalid>
        <name>GRK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        </entity>
      </gene>
      <gene>
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        <name>CAMKK1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADCY6</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>CAMK4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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          <protein>
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          <protein>
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      <gene>
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        <name>PRKACA</name>
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          <protein>
            <xref>
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          <protein>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
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      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>dioxygen</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>testosterone</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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        <name>MCF2</name>
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          <protein>
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              <externalid>A0A3Q1M3Z3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SFN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TPM3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5KR47</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MPP7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QQZ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DOCK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK77</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYQ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP39</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNB6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PLEKHG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBN2</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CPSF7</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FERMT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB21</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SKA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEK5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407601</externalid>
        <name>DLC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTN1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B7N2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRV3</externalid>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L6</externalid>
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          </protein>
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      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUM6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC4A7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386792</externalid>
        <name>GPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME43</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L1</externalid>
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          </protein>
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      <gene>
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        <name>SEC13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
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      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
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      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
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      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
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      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
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      <smallmolecule>
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        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
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      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>formaldehyde</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-9012999</externalid>
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      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-194315</externalid>
        <linkedsystemtype>
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      <linkedsystem>
        <externalid>R-BTA-9716542</externalid>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9012999</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q8SPJ1</externalid>
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      <gene>
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              <externalid>E1BNV7</externalid>
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              <externalid>E1BN47</externalid>
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      <gene>
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              <externalid>Q3SX08</externalid>
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      <gene>
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        <name>DEF6</name>
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              <externalid>A5PK34</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TAGAP</name>
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              <externalid>Q08DB1</externalid>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-8980692</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013106</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013404</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013423</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
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      <linkedsystem>
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        </linkedsystemtype>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-HSA-9012999</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194315</externalid>
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          <superset />
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8980692</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
        <externalid>R-HSA-8980692</externalid>
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      <linkedsystem>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013106</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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        <name>NCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQK6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LMAN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407623</externalid>
        <name>ARAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBA0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409203</externalid>
        <name>NHS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWH1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408952</externalid>
        <name>DIAPH3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ABI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369862</externalid>
        <name>VRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N078</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340981</externalid>
        <name>PREX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1Q7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>BAIAP2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>BCR</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MCF2</name>
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          </protein>
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      <gene>
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        <name>ESYT1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>NOXO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQZ7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PIK3R2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>TFRC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIG6</externalid>
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          </protein>
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      <gene>
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        <name>DOCK10</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CYBB</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FERMT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323309</externalid>
        <name>LAMTOR1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0D8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>ABR</name>
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              <externalid>A6QNS3</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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      <smallmolecule>
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        <name>FAD(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
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          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9013423</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9012999</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-9013408</externalid>
    <name>RHOG GTPase cycle</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013408</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MC61</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>F1MHG5</externalid>
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          </protein>
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      <gene>
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        <name>CYFIP1</name>
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              <externalid>E1BN47</externalid>
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          </protein>
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      <gene>
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              <externalid>F1MJ73</externalid>
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              <externalid>F6QJJ8</externalid>
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          </protein>
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      <gene>
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        <name>RHOG</name>
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              <externalid>Q1RMI2</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>E1BM23</externalid>
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              <externalid>Q3T000</externalid>
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          </protein>
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      <gene>
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        <name>NDUFA5</name>
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              <externalid>P23935</externalid>
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          </protein>
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      <gene>
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        <name>KTN1</name>
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              <externalid>A0A3Q1LVS2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PAK2</name>
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              <externalid>A0A3Q1M0G8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VAV3</name>
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          <protein>
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              <externalid>E1BBD2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OPHN1</name>
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              <externalid>A0A3Q1N6J8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP32</name>
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              <externalid>A0A3Q1MMX7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGEF5</name>
        <entity>
          <protein>
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              <externalid>F1N2G5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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        <externalid>R-HSA-9013408</externalid>
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      <linkedsystem>
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    <name>CDC42 GTPase cycle</name>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013148</url>
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              <externalid>E1BNV7</externalid>
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          </protein>
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        <name>SRGAP1</name>
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              <externalid>F1MFS4</externalid>
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      <gene>
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              <externalid>E1BDY4</externalid>
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      <gene>
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              <externalid>F1MXU4</externalid>
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              <externalid>E1BCC1</externalid>
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      <gene>
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      <gene>
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              <externalid>E1BDL7</externalid>
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      <gene>
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              <externalid>E1BM23</externalid>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760857</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5627117</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5627123</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5625740</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5625900</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5625970</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5626467</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5627083</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5663213</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5663220</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5666185</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5668599</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-195258</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5627117</externalid>
    <name>RHO GTPases Activate ROCKs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5627117</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340371</externalid>
        <name>RHOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340856</externalid>
        <name>ROCK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330477</externalid>
        <name>ROCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5627117</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5627123</externalid>
    <name>RHO GTPases activate PAKs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5627123</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>59351</externalid>
        <name>MYL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60661</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370127</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343918</externalid>
        <name>MYL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>5671950</externalid>
        <name>MYH14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385594</externalid>
        <name>MYL12B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>5671948</externalid>
        <name>MYH9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>5671941</externalid>
        <name>MYH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370123</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342883</externalid>
        <name>FLNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340085</externalid>
        <name>LIMK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344071</externalid>
        <name>MYLK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28824</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>95867</externalid>
        <name>MYH10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27991</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370132</externalid>
        <name>PPP1CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5627123</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5625740</externalid>
    <name>RHO GTPases activate PKNs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5625740</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380226</externalid>
        <name>PKN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316895</externalid>
        <name>YWHAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370127</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316883</externalid>
        <name>YWHAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z057</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370123</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380234</externalid>
        <name>PKN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383025</externalid>
        <name>PPP1R14A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316877</externalid>
        <name>YWHAH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68509</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352902</externalid>
        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370132</externalid>
        <name>PPP1CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335862</externalid>
        <name>AR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316889</externalid>
        <name>SFN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375463</externalid>
        <name>KDM4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340371</externalid>
        <name>RHOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315702</externalid>
        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380230</externalid>
        <name>PKN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316868</externalid>
        <name>CDC25C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5625886</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5625740</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5625886</externalid>
    <name>Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5625886</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380226</externalid>
        <name>PKN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352902</externalid>
        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>AR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327615</externalid>
        <name>NCOA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>56227</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM4C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT70</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312676</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
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          </protein>
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      <gene>
        <externalid>10312652</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
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      <gene>
        <externalid>10312692</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>HIST1H2BI</name>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
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        <name>dioxygen</name>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5625886</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5625740</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5625900</externalid>
    <name>RHO GTPases activate CIT</name>
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    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-5625900</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RHOA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KIF14</name>
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              <externalid>G5E5S3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOC</name>
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              <externalid>Q1RMJ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRC1</name>
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              <externalid>Q2T9P1</externalid>
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          </protein>
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      <gene>
        <externalid>10383039</externalid>
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              <externalid>A0A3Q1LV55</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5625900</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5625970</externalid>
    <name>RHO GTPases activate KTN1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5625970</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10320234</externalid>
        <name>RHOA</name>
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              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352397</externalid>
        <name>KLC3</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MR65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352407</externalid>
        <name>KIF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320214</externalid>
        <name>RHOG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352411</externalid>
        <name>KIF5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1G7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352401</externalid>
        <name>KLC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352389</externalid>
        <name>KLC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380765</externalid>
        <name>KTN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352393</externalid>
        <name>KLC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5625970</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5626467</externalid>
    <name>RHO GTPases activate IQGAPs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5626467</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10366516</externalid>
        <name>MEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345452</externalid>
        <name>IQGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380814</externalid>
        <name>IQGAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7H0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380808</externalid>
        <name>IQGAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335621</externalid>
        <name>CTNNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9M0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331499</externalid>
        <name>CDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5626467</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5627083</externalid>
    <name>RHO GTPases regulate CFTR trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5627083</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338758</externalid>
        <name>CFTR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380916</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380904</externalid>
        <name>GOPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5627083</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5663213</externalid>
    <name>RHO GTPases Activate WASPs and WAVEs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5663213</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10363986</externalid>
        <name>NCKIPSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363960</externalid>
        <name>WASF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335773</externalid>
        <name>ABL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363970</externalid>
        <name>CYFIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363950</externalid>
        <name>ABI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363942</externalid>
        <name>BRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8YXX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363934</externalid>
        <name>BAIAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7W5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363974</externalid>
        <name>CYFIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217381</externalid>
        <name>ARPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217374</externalid>
        <name>ARPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360402</externalid>
        <name>ARPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363980</externalid>
        <name>NCKAP1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B876</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217376</externalid>
        <name>ARPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360395</externalid>
        <name>ARPC1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>50305</externalid>
        <name>ACTR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61157</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363964</externalid>
        <name>WASF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217383</externalid>
        <name>ARPC1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>354511</externalid>
        <name>ACTR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363956</externalid>
        <name>WASF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5663213</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5663220</externalid>
    <name>RHO GTPases Activate Formins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5663220</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10321222</externalid>
        <name>SGO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321296</externalid>
        <name>B9D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321272</externalid>
        <name>XPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321406</externalid>
        <name>SPC25</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDCA8</name>
        <entity>
          <protein>
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              <externalid>A4IFM5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLASP1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPI</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTB</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERCC6L</name>
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          </protein>
        </entity>
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      <gene>
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              <externalid>E1BBQ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PFN1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDEL1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N184</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZWILCH</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QM04</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DVL3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MMW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R5E</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CKAP5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B7K5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SGO1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MR95</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP1CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61287</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FMNL3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B718</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SKA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SRGAP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMM5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1RMJ6</externalid>
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          </protein>
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      <gene>
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        <name>ZW10</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>NUDC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SPC24</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CDC42</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L1</externalid>
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          </protein>
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      <gene>
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        <name>SEC13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-5663220</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
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          <superset />
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    </linkedsystems>
  </biosystem>
  <biosystem>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RHOA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FUC9</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KIB6</externalid>
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          </protein>
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      <gene>
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        <name>RTKN</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS34</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <externalid>A0A3Q1LJH7</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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    </linkedsystems>
  </biosystem>
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    <name>RHO GTPases Activate NADPH Oxidases</name>
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    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MKI4</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>MAPK11</name>
        <entity>
          <protein>
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              <externalid>G3X793</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>F1MZX0</externalid>
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          </protein>
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      <gene>
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        <name>PRKCZ</name>
        <entity>
          <protein>
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              <externalid>A0JNH7</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MAPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NOX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFF3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28782</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU25</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P05126</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353688</externalid>
        <name>CYBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NCF2</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MTW8</externalid>
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          </protein>
        </entity>
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          <externalid>58088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5668599</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-195258</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9706019</externalid>
    <name>RHOBTB3 ATPase cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9706019</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336139</externalid>
        <name>HTR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391550</externalid>
        <name>RAB9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397797</externalid>
        <name>RHOBTB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351934</externalid>
        <name>LRRC41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2Y1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397778</externalid>
        <name>M6PRBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351922</externalid>
        <name>CUL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397768</externalid>
        <name>RAB9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9706019</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9716542</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9715370</externalid>
    <name>Miro GTPase Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9715370</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409647</externalid>
        <name>RHOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409629</externalid>
        <name>MYO19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388282</externalid>
        <name>RHOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409637</externalid>
        <name>TRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409633</externalid>
        <name>TRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352827</externalid>
        <name>MFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7GLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9013425</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9013419</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9715370</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9716542</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9013425</externalid>
    <name>RHOT1 GTPase cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013425</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409629</externalid>
        <name>MYO19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388282</externalid>
        <name>RHOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409637</externalid>
        <name>TRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409633</externalid>
        <name>TRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9013425</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9715370</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9013419</externalid>
    <name>RHOT2 GTPase cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013419</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409647</externalid>
        <name>RHOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409629</externalid>
        <name>MYO19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409637</externalid>
        <name>TRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352827</externalid>
        <name>MFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7GLD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352831</externalid>
        <name>MFN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPL1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9013419</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9715370</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9006927</externalid>
    <name>Signaling by Non-Receptor Tyrosine Kinases</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9006927</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>GPNMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340725</externalid>
        <name>DOCK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KRAS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326642</externalid>
        <name>RASA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347324</externalid>
        <name>SOCS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BEG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337990</externalid>
        <name>STAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340360</externalid>
        <name>ARHGAP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B801</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354381</externalid>
        <name>ERBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398628</externalid>
        <name>SFPQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354016</externalid>
        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326085</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398453</externalid>
        <name>ARAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366694</externalid>
        <name>ELMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398501</externalid>
        <name>KHDRBS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326062</externalid>
        <name>HBEGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353835</externalid>
        <name>HIF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398534</externalid>
        <name>SRMS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366690</externalid>
        <name>ELMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326058</externalid>
        <name>EREG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324170</externalid>
        <name>CRK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398428</externalid>
        <name>DOK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398096</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QAM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400243</externalid>
        <name>LRRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398491</externalid>
        <name>KHDRBS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398471</externalid>
        <name>KHDRBS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354024</externalid>
        <name>NRG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8848021</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9006927</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8848021</externalid>
    <name>Signaling by PTK6</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8848021</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10400225</externalid>
        <name>GPNMB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340725</externalid>
        <name>DOCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326642</externalid>
        <name>RASA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326323</externalid>
        <name>CBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LN00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347324</externalid>
        <name>SOCS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BEG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337990</externalid>
        <name>STAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340360</externalid>
        <name>ARHGAP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B801</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354381</externalid>
        <name>ERBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398628</externalid>
        <name>SFPQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335244</externalid>
        <name>ERBB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334871</externalid>
        <name>BCAR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354016</externalid>
        <name>NRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326085</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398453</externalid>
        <name>ARAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4A0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354006</externalid>
        <name>ERBB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354020</externalid>
        <name>NRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366694</externalid>
        <name>ELMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NMX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398501</externalid>
        <name>KHDRBS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326038</externalid>
        <name>EGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323003</externalid>
        <entity>
          <protein>
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              <externalid>E1B986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RRAGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330045</externalid>
        <name>PRKAG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LL38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-165181</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166208</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-380972</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-165159</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Inhibition of TSC complex formation by PKB</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>TSC1</name>
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          </protein>
        </entity>
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      <gene>
        <externalid>10323255</externalid>
        <entity>
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          </protein>
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      <gene>
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        <name>AKT2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-165181</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-165159</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>YWHAB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MLST8</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>FKBP1A</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <taxnode>
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          </protein>
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      <gene>
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              <externalid>Q29RI6</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>Q5BIS9</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>STK11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BCU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LAMTOR2</name>
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          <protein>
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              <externalid>Q3T132</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58108</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHEB</name>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
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              <externalid>F1MQV7</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>Q3SZ68</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
            <xref>
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              <externalid>O62829</externalid>
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          </protein>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-165159</externalid>
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  <biosystem>
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    <name>Death Receptor Signaling</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5D7R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LINGO1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MBT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2D1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OTUD7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BAD</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKG</name>
        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>MAPKAPK2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SQSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLIP3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAL0</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CASP8</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MYD88</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PRKCI</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>BIRC2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ULK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK8</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10318287</externalid>
        <name>RNF31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMK3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10380888</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N495</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>bIkBa</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
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          </protein>
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      <gene>
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        <name>APH1A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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        <name>XIAP</name>
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          </protein>
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      <gene>
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        <name>MAG</name>
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          </protein>
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      <gene>
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            <xref>
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              <externalid>F1MQ36</externalid>
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      <gene>
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        <name>STUB1</name>
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      <gene>
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          </protein>
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        <name>YWHAE</name>
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            <xref>
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              <externalid>P62261</externalid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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    </genes>
    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-75157</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75893</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193704</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-73887</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>FasL/ CD95L signaling</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75157</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CASP8</name>
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      <gene>
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        <name>FADD</name>
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              <externalid>Q645M6</externalid>
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      <gene>
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              <externalid>A6H6Z6</externalid>
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          </protein>
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      <gene>
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        <name>FAS</name>
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              <externalid>A5D7R0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73887</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>TNF signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75893</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1M5N0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OTULIN</name>
        <entity>
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              <externalid>A6QLU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>USP4</name>
        <entity>
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              <externalid>A6QR55</externalid>
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          </protein>
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      <gene>
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        <name>RACK1</name>
        <entity>
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              <externalid>P63243</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SPPL2B</name>
        <entity>
          <protein>
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              <externalid>E1BKF8</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q3MHP1</externalid>
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          </protein>
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      <gene>
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        <name>MIB2</name>
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              <externalid>E1BBN5</externalid>
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          </protein>
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      <gene>
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        <name>MAP3K7</name>
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          <protein>
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              <externalid>A2VDU3</externalid>
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          </protein>
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      <gene>
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        <name>USP21</name>
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              <externalid>A0A3Q1LYE6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SPATA2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BLR1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ADAM17</name>
        <entity>
          <protein>
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              <externalid>E1B867</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FADD</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q645M6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OPTN</name>
        <entity>
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            <xref>
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              <externalid>Q3ZC32</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>USP2</name>
        <entity>
          <protein>
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              <externalid>Q2KHV7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3SZK6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321014</externalid>
        <name>OTUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1M7T8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318291</externalid>
        <name>SHARPIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380874</externalid>
        <name>MADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318283</externalid>
        <name>C20orf18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349276</externalid>
        <name>TAX1BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358478</externalid>
        <name>SMPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318230</externalid>
        <name>TNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400550</externalid>
        <name>SPPL2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318336</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318236</externalid>
        <name>TNFRSF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321010</externalid>
        <name>OTUD7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9S7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378069</externalid>
        <name>TRAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378090</externalid>
        <name>CLIP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358922</externalid>
        <name>ULK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318279</externalid>
        <name>CYLD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318287</externalid>
        <name>RNF31</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10380888</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N495</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
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          <protein>
            <xref>
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              <externalid>E1B7G3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
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              <externalid>E1B7Z0</externalid>
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        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-5357905</externalid>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73887</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>TNFR1-induced NF-kappa-B signaling pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5357956</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>C20orf18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320998</externalid>
        <name>USP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378047</externalid>
        <name>RACK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63243</externalid>
            </xref>
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        </entity>
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      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318230</externalid>
        <name>TNF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318218</externalid>
        <name>TRADD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318236</externalid>
        <name>TNFRSF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKI9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321002</externalid>
        <name>USP21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318297</externalid>
        <name>SPATA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321010</externalid>
        <name>OTUD7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9S7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368756</externalid>
        <name>OPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321006</externalid>
        <name>USP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378069</externalid>
        <name>TRAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321014</externalid>
        <name>OTUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318279</externalid>
        <name>CYLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318287</externalid>
        <name>RNF31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318291</externalid>
        <name>SHARPIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5357956</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75893</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
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      <gene>
        <externalid>10318287</externalid>
        <name>RNF31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318273</externalid>
        <name>XIAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5357905</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75893</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193704</externalid>
    <name>p75 NTR receptor-mediated signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193704</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328123</externalid>
        <name>OMG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q889</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328003</externalid>
        <name>BEX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320651</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328377</externalid>
        <name>MCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Z3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321348</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328133</externalid>
        <name>LINGO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328045</externalid>
        <name>ADAM17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320575</externalid>
        <name>BAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327967</externalid>
        <name>SQSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328086</externalid>
        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328078</externalid>
        <name>PSEN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321352</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328381</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327991</externalid>
        <name>ARHGDIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328119</externalid>
        <name>MAG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QYA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332380</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328060</externalid>
        <name>PSENEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5G235</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327963</externalid>
        <name>NGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328127</externalid>
        <name>RTN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N405</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-205017</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-204998</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193639</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193697</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193692</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-193704</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73887</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-205017</externalid>
    <name>NFG and proNGF binds to p75NTR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-205017</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327963</externalid>
        <name>NGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-205017</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193704</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-204998</externalid>
    <name>Cell death signalling via NRAGE, NRIF and NADE</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-204998</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328003</externalid>
        <name>BEX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320651</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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      <smallmolecule>
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              <externalid>F1MIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-209543</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209560</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-193639</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193704</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209543</externalid>
    <name>p75NTR recruits signalling complexes</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>UBC</name>
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          <protein>
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              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
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          <protein>
            <xref>
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              <externalid>A0A3Q1N6X2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327967</externalid>
        <name>SQSTM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>IKBKB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-HSA-209543</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193639</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209560</externalid>
    <name>NF-kB is activated and signals survival</name>
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      <organism_specific_biosystem />
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      <taxnode>
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        <name>UBC</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327963</externalid>
        <name>NGFR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SQSTM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-209560</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193639</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193697</externalid>
    <name>p75NTR regulates axonogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>LINGO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320234</externalid>
        <name>RHOA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327991</externalid>
        <name>ARHGDIA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ82</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328123</externalid>
        <name>OMG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q889</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323647</externalid>
        <name>NGF</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6X2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QYA3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NGFR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MCF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Z3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RTN4</name>
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              <externalid>F1N405</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MRV3</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
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        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <subset />
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193704</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
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  </biosystem>
  <biosystem>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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        <name>RHOA</name>
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          </protein>
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      </gene>
      <gene>
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              <externalid>A0A452DJ82</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NGFR</name>
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          <protein>
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              <externalid>A5PJV7</externalid>
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          </protein>
        </entity>
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        <name>GDP(3-)</name>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-209563</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>F1MBT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RHOA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGDIA</name>
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          <protein>
            <xref>
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              <externalid>A0A452DJ82</externalid>
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      </gene>
      <gene>
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              <externalid>F6Q889</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328119</externalid>
        <name>MAG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QYA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NGFR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>A0A3Q1M3Z3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N405</externalid>
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          </protein>
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      <gene>
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            <xref>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193634</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193697</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-193692</externalid>
    <name>Regulated proteolysis of p75NTR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-193692</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328074</externalid>
        <name>NCSTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328045</externalid>
        <name>ADAM17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328068</externalid>
        <name>APH1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328064</externalid>
        <name>APH1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328060</externalid>
        <name>PSENEN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5G235</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328078</externalid>
        <name>PSEN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327963</externalid>
        <name>NGFR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328086</externalid>
        <name>PSEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-193692</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-193704</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9006335</externalid>
    <name>Signaling by Erythropoietin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9006335</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10408861</externalid>
        <name>EPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48617</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338953</externalid>
        <name>PIK3CD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408865</externalid>
        <name>EPOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9027276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9027284</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9006335</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162582</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9027276</externalid>
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    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9027276</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338953</externalid>
        <name>PIK3CD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318569</externalid>
        <name>GAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338941</externalid>
        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338937</externalid>
        <name>PIK3CG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408861</externalid>
        <name>EPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48617</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408865</externalid>
        <name>EPOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9027276</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9006335</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Erythropoietin activates RAS</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408861</externalid>
        <name>EPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48617</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324612</externalid>
        <name>RAPGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324606</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N016</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316449</externalid>
        <name>IRS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408865</externalid>
        <name>EPOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEQ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9027284</externalid>
        <linkedsystemtype>
          <linked />
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>KICS2</name>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
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      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31507</externalid>
        <name>P(1),P(4)-bis(5'-guanosyl) tetraphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31617</externalid>
        <name>hydroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661234</externalid>
        <name>arsenic(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163065</externalid>
        <name>cadmium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48775</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5660526</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9855142</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8953897</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5660526</externalid>
    <name>Response to metal ions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5660526</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10382391</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382387</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382395</externalid>
        <name>MT2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68301</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382379</externalid>
        <name>LOC613358</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382375</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382383</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382458</externalid>
        <name>MT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P37359</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661234</externalid>
        <name>arsenic(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163065</externalid>
        <name>cadmium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48775</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5661231</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5660526</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5661231</externalid>
    <name>Metallothioneins bind metals</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5661231</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10382391</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382387</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382395</externalid>
        <name>MT2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68301</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382379</externalid>
        <name>LOC613358</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382375</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382383</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382458</externalid>
        <name>MT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P37359</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5661234</externalid>
        <name>arsenic(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35828</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163065</externalid>
        <name>cadmium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48775</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5661231</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5660526</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2262752</externalid>
    <name>Cellular responses to stress</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2262752</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619732</externalid>
        <name>TUBB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370822</externalid>
        <name>MAPKAPK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312606</externalid>
        <name>MRE11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373659</externalid>
        <name>CABIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X746</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>KICS2</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
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      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
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      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
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      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
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      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31507</externalid>
        <name>P(1),P(4)-bis(5'-guanosyl) tetraphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31617</externalid>
        <name>hydroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1234174</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371556</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559583</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371497</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9707616</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711123</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711097</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9840373</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9841251</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2262752</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1234174</externalid>
    <name>Cellular response to hypoxia</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1234174</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319923</externalid>
        <name>ELOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353940</externalid>
        <name>EGLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319927</externalid>
        <name>TCEB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353866</externalid>
        <name>EGLN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353829</externalid>
        <name>EPAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353852</externalid>
        <name>LIMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5X0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353841</externalid>
        <name>HIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RL11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
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          <protein>
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              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2D2</name>
        <entity>
          <protein>
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              <externalid>Q1RMX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353923</externalid>
        <name>HIF1AN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353856</externalid>
        <name>AJUBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353860</externalid>
        <name>WTIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353955</externalid>
        <name>CITED2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351830</externalid>
        <name>CUL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353835</externalid>
        <name>HIF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353872</externalid>
        <name>EGLN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1234176</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1234158</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1234174</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1234176</externalid>
    <name>Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1234176</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319923</externalid>
        <name>ELOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353940</externalid>
        <name>EGLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319927</externalid>
        <name>TCEB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ32</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353866</externalid>
        <name>EGLN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10353829</externalid>
        <name>EPAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353852</externalid>
        <name>LIMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5X0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353841</externalid>
        <name>HIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RL11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353856</externalid>
        <name>AJUBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
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          </protein>
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      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>WTIP</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BP33</externalid>
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          </protein>
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      <gene>
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        <name>PSMB4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CUL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
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          </protein>
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      <gene>
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        <name>HIF1A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0JND0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EGLN1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD11</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422661</externalid>
        <name>L-ascorbate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>38290</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1234176</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1234174</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Regulation of gene expression by Hypoxia-inducible Factor</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1234158</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353841</externalid>
        <name>HIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RL11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353955</externalid>
        <name>CITED2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317863</externalid>
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      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372343</externalid>
        <name>RPS19BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372262</externalid>
        <name>DNAJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317163</externalid>
        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317117</externalid>
        <name>NUP54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377666</externalid>
        <name>BAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317189</externalid>
        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3371511</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371571</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371453</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-3371556</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3371511</externalid>
    <name>HSF1 activation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334318</externalid>
        <name>HDAC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321630</externalid>
        <name>EEF1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3371511</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3371571</externalid>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>HSBP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323291</externalid>
        <name>MLST8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372262</externalid>
        <name>DNAJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FKBP4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375707</externalid>
        <name>CRYAB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02510</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372238</externalid>
        <name>HSPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E3Q2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375711</externalid>
        <name>HSPB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323295</externalid>
        <name>MTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372234</externalid>
        <name>HSPA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CB32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323299</externalid>
        <name>RPTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG06</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P19120</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323378</externalid>
        <name>AKT1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N197</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3371568</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-3371571</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Attenuation phase</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3371568</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10372365</externalid>
        <name>HSBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372262</externalid>
        <name>DNAJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377712</externalid>
        <name>FKBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372238</externalid>
        <name>HSPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E3Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372234</externalid>
        <name>HSPA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CB32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3371568</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371571</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3371453</externalid>
    <name>Regulation of HSF1-mediated heat shock response</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3371453</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377570</externalid>
        <name>DNAJC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377658</externalid>
        <name>HSPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377430</externalid>
        <name>HSPA13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377662</externalid>
        <name>BAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377424</externalid>
        <name>HSPA12B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377436</externalid>
        <name>HSPA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377474</externalid>
        <name>HSPA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377418</externalid>
        <name>HSPA12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377412</externalid>
        <name>HIKESHI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377462</externalid>
        <name>HSPA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372238</externalid>
        <name>HSPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E3Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377446</externalid>
        <name>HSPA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372234</externalid>
        <name>HSPA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CB32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317127</externalid>
        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338067</externalid>
        <name>HSPA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341989</externalid>
        <name>SIRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318336</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317131</externalid>
        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377670</externalid>
        <name>BAG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317159</externalid>
        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377679</externalid>
        <name>ST13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E3S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372343</externalid>
        <name>RPS19BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372262</externalid>
        <name>DNAJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317163</externalid>
        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317117</externalid>
        <name>NUP54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377666</externalid>
        <name>BAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317189</externalid>
        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3371453</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3371556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2559583</externalid>
    <name>Cellular Senescence</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2559583</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POT1</name>
        <entity>
          <protein>
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              <externalid>E1BGK3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>UBE2S</name>
        <entity>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ETS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312606</externalid>
        <name>MRE11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN9</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MAPK9</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373659</externalid>
        <name>CABIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X746</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNE2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>G3N011</externalid>
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          </protein>
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      <gene>
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        <name>LOC528006</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>JUN</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>RPS6KA2</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>ATM</name>
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          </protein>
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      <gene>
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        <name>UBC</name>
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          </protein>
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      <gene>
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        <name>RNF2</name>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
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        <name>reactive oxygen species</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>acetyl-CoA(4-)</name>
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          <externalid>57288</externalid>
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      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
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      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559586</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559582</externalid>
        <linkedsystemtype>
          <subset />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2559583</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <smallmolecule>
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          </protein>
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      <gene>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326309</externalid>
        <name>CDKN2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CBX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PHC2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BFG7</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MAPKAPK2</name>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>TP53</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>RBBP7</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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        <name>reactive oxygen species</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      <smallmolecule>
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        <name>2-oxoglutarate(2-)</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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        <name>iron(2+)</name>
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      <smallmolecule>
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        <name>succinate(2-)</name>
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      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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        <externalid>R-HSA-2559580</externalid>
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      <linkedsystem>
        <externalid>R-BTA-2559583</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>DNA Damage/Telomere Stress Induced Senescence</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2559586</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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        <name>CCNA1</name>
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          </protein>
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      <gene>
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        <name>MRE11</name>
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              <externalid>E1BIN9</externalid>
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          </protein>
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        <name>HIRA</name>
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              <externalid>F1N3C8</externalid>
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      <gene>
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        <name>CABIN1</name>
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              <externalid>G3X746</externalid>
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          </protein>
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      <gene>
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        <name>CCNE2</name>
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          </protein>
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      <gene>
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        <name>CDKN1B</name>
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              <externalid>A6QLS3</externalid>
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          </protein>
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      <gene>
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        <name>TERF2</name>
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              <externalid>F1MMS4</externalid>
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          </protein>
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      <gene>
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        <name>LOC528006</name>
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              <externalid>Q0VBX4</externalid>
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          </protein>
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      <gene>
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        <name>EP400</name>
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              <externalid>F1MLB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KAT5</name>
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              <externalid>E1BMS5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1BDE9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312623</externalid>
        <name>ATM</name>
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              <externalid>E1BEI6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373655</externalid>
        <name>UBN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ACD</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10373647</externalid>
        <name>ASF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIG1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312776</externalid>
        <name>H3-4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWX6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
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      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
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          </protein>
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      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
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      <gene>
        <externalid>10315685</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
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          </protein>
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      <gene>
        <externalid>10312652</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
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      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
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          </protein>
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      <gene>
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        <name>RAD50</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6W2</externalid>
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          </protein>
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      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
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      <gene>
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        <name>TINF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
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          </protein>
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      <gene>
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        <name>NBN</name>
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              <externalid>F6PSE2</externalid>
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      <gene>
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        <entity>
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              <externalid>G5E6T5</externalid>
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          </protein>
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      <gene>
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        <name>H2AZ2</name>
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      <gene>
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          <protein>
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              <externalid>E1B9U2</externalid>
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      <gene>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
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          <externalid>57287</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2559586</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559583</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Formation of Senescence-Associated Heterochromatin Foci (SAHF)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2559584</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q2KIG1</externalid>
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          </protein>
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      <gene>
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        <name>HIRA</name>
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              <externalid>F1N3C8</externalid>
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          </protein>
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      <gene>
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        <name>UBN1</name>
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              <externalid>E1BAS8</externalid>
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          </protein>
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      <gene>
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        <name>CABIN1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3X746</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559586</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2559582</externalid>
    <name>Senescence-Associated Secretory Phenotype (SASP)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2559582</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10312704</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
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          </protein>
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      <gene>
        <externalid>10312754</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5E9Y0</externalid>
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          </protein>
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      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311662</externalid>
        <name>ANAPC11</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3ZCF6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311646</externalid>
        <name>ANAPC7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
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          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2559582</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2559583</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3371497</externalid>
    <name>HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3371497</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10372250</externalid>
        <name>DNAJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E954</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379922</externalid>
        <name>FKBP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619732</externalid>
        <name>TUBB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372256</externalid>
        <name>DNAJA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335962</externalid>
        <name>NR3C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337700</externalid>
        <name>DCTN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Y3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321498</externalid>
        <name>DYNC1LI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250617</externalid>
        <name>TUBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335862</externalid>
        <name>AR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377712</externalid>
        <name>FKBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337715</externalid>
        <name>DCTN3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DCTN6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148G7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TUBB6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ81</externalid>
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          </protein>
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      <gene>
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        <name>PGR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C1</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN19</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TUBA1C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQR2</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10366878</externalid>
        <name>ACTR10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TUBB4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321482</externalid>
        <name>DYNC1H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321502</externalid>
        <name>DYNC1LI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333961</externalid>
        <name>PTGES3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU3</externalid>
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          </protein>
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      <gene>
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        <name>TUBB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJK2</externalid>
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          </protein>
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      <gene>
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        <name>STIP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBZ8</externalid>
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          </protein>
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      <gene>
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        <name>DCTN2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF0</externalid>
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          </protein>
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      <gene>
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        <name>DCTN4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBI8</externalid>
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          </protein>
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      <gene>
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        <name>TUBA4A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81948</externalid>
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          </protein>
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      <gene>
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        <name>DNAJB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI00</externalid>
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          </protein>
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      <gene>
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        <name>LOC100141266</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNF8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TUBAL3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6J5</externalid>
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          </protein>
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      <gene>
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        <name>HSPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E3Q2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321488</externalid>
        <name>DYNC1I1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RQ3</externalid>
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          </protein>
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      <gene>
        <externalid>250602</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJB8</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F0</externalid>
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          </protein>
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      <gene>
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        <name>DYNLL2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU7</externalid>
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      <gene>
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              <externalid>Q3ZCJ7</externalid>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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        <name>cortisol</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
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      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>corticosterone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
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        <externalid>R-HSA-3371497</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Heme signaling</name>
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    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-9707616</url>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>E1BJL3</externalid>
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        <name>PGRMC2</name>
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              <externalid>F6QJJ8</externalid>
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              <externalid>E1BNR0</externalid>
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      <gene>
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        <name>HBB</name>
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              <externalid>P02070</externalid>
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      <gene>
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              <externalid>E1BB01</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58CN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395538</externalid>
        <name>NOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340176</externalid>
        <name>SMARCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322667</externalid>
        <name>COX7A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T857</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371927</externalid>
        <name>TXN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387943</externalid>
        <name>NUDT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31507</externalid>
        <name>P(1),P(4)-bis(5'-guanosyl) tetraphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31617</externalid>
        <name>hydroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9755511</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9707564</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3299685</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9711123</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9755511</externalid>
    <name>KEAP1-NFE2L2 pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9755511</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10413458</externalid>
        <name>BACH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351486</externalid>
        <name>TRIM21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403388</externalid>
        <name>NFE2L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413564</externalid>
        <name>FBXL17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415001</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407190</externalid>
        <name>UBXN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381001</externalid>
        <name>SESN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376349</externalid>
        <name>MAP1LC3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O41515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388303</externalid>
        <name>MUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353029</externalid>
        <name>MAFK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382143</externalid>
        <name>UFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N3E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327967</externalid>
        <name>SQSTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372003</externalid>
        <name>PRDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E947</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382139</externalid>
        <name>NPLOC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380997</externalid>
        <name>SESN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351836</externalid>
        <name>KEAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351922</externalid>
        <name>CUL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9759194</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9708530</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9755511</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711123</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9759194</externalid>
    <name>Nuclear events mediated by NFE2L2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9759194</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403388</externalid>
        <name>NFE2L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372003</externalid>
        <name>PRDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E947</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415001</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9762114</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9818027</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9759194</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9755511</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9762114</externalid>
    <name>GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9762114</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403388</externalid>
        <name>NFE2L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9762114</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
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  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogen peroxide</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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              <externalid>A0A3Q1MB49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340176</externalid>
        <name>SMARCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322657</externalid>
        <name>COX6B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6YFP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322667</externalid>
        <name>COX7A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T857</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327530</externalid>
        <name>TGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760854</externalid>
        <name>biliverdin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31973</externalid>
        <name>linoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17351</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31617</externalid>
        <name>hydroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760858</externalid>
        <name>bilirubin(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57977</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316907</externalid>
        <name>hydroxyl</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29191</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9707587</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9707564</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711123</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9707587</externalid>
    <name>Regulation of HMOX1 expression and activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9707587</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326956</externalid>
        <name>HMOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413550</externalid>
        <name>HM13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9707587</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9707564</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3299685</externalid>
    <name>Detoxification of Reactive Oxygen Species</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3299685</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346267</externalid>
        <name>SOD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00442</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>103882</externalid>
        <name>TXNRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62768</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371988</externalid>
        <name>GPX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371456</externalid>
        <name>SOD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R4N7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372009</externalid>
        <name>PRDX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BGI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371934</externalid>
        <name>PRDX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35705</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346263</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314176</externalid>
        <name>GPX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00435</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353688</externalid>
        <name>CYBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372003</externalid>
        <name>PRDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E947</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371445</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325641</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372032</externalid>
        <name>PRDX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77834</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353706</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371992</externalid>
        <name>GPX8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371484</externalid>
        <name>CCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371942</externalid>
        <name>PRDX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BGI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393698</externalid>
        <name>GPX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395544</externalid>
        <name>NOX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395538</externalid>
        <name>NOX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371958</externalid>
        <name>TXNRD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N2I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314186</externalid>
        <name>GSR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371984</externalid>
        <name>ERO1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372022</externalid>
        <name>GPX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P37141</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371927</externalid>
        <name>TXN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393702</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317602</externalid>
        <name>CAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353702</externalid>
        <name>NCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387943</externalid>
        <name>NUDT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114757</externalid>
        <name>glutathione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222357</externalid>
        <name>peroxynitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25941</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31507</externalid>
        <name>P(1),P(4)-bis(5'-guanosyl) tetraphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3299685</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711123</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9711097</externalid>
    <name>Cellular response to starvation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9711097</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323281</externalid>
        <name>RHEB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411574</externalid>
        <name>DEPDC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323291</externalid>
        <name>MLST8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323317</externalid>
        <name>LAMTOR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323305</externalid>
        <name>SLC38A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381001</externalid>
        <name>SESN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323321</externalid>
        <name>LAMTOR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2M2U3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323331</externalid>
        <name>RRAGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411560</externalid>
        <name>WDR24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411598</externalid>
        <name>SZT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411594</externalid>
        <name>KPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323345</externalid>
        <name>RRAGC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323295</externalid>
        <name>MTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411828</externalid>
        <name>FNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411645</externalid>
        <name>CASTOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N308</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411623</externalid>
        <name>SH3BP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323313</externalid>
        <name>LAMTOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411580</externalid>
        <name>NPRL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323299</externalid>
        <name>RPTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411655</externalid>
        <name>BMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7X8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323309</externalid>
        <name>LAMTOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323325</externalid>
        <name>LAMTOR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323351</externalid>
        <name>RRAGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411552</externalid>
        <name>MIOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B899</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411564</externalid>
        <name>WDR59</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380997</externalid>
        <name>SESN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411820</externalid>
        <name>FLCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B7L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411586</externalid>
        <name>KICS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411641</externalid>
        <name>CASTOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323337</externalid>
        <name>RRAGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9639288</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9711097</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9639288</externalid>
    <name>Amino acids regulate mTORC1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9639288</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411590</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323281</externalid>
        <name>RHEB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411574</externalid>
        <name>DEPDC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323291</externalid>
        <name>MLST8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323317</externalid>
        <name>LAMTOR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323305</externalid>
        <name>SLC38A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381001</externalid>
        <name>SESN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323321</externalid>
        <name>LAMTOR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2M2U3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323331</externalid>
        <name>RRAGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411560</externalid>
        <name>WDR24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411598</externalid>
        <name>SZT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411594</externalid>
        <name>KPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323345</externalid>
        <name>RRAGC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323295</externalid>
        <name>MTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411828</externalid>
        <name>FNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411645</externalid>
        <name>CASTOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N308</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411623</externalid>
        <name>SH3BP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323313</externalid>
        <name>LAMTOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T132</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411580</externalid>
        <name>NPRL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323299</externalid>
        <name>RPTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411655</externalid>
        <name>BMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7X8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323309</externalid>
        <name>LAMTOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323325</externalid>
        <name>LAMTOR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323351</externalid>
        <name>RRAGD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411552</externalid>
        <name>MIOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B899</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411564</externalid>
        <name>WDR59</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380997</externalid>
        <name>SESN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411820</externalid>
        <name>FLCN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B7L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411586</externalid>
        <name>KICS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411641</externalid>
        <name>CASTOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323337</externalid>
        <name>RRAGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943614</externalid>
        <name>L-leucine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57427</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9639288</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9711097</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381119</externalid>
    <name>Unfolded Protein Response (UPR)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381119</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402473</externalid>
        <name>CREBRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338077</externalid>
        <name>ERN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341215</externalid>
        <name>MBTPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402374</externalid>
        <name>CREB3L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338055</externalid>
        <name>ATF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338063</externalid>
        <name>EIF2AK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D791</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402349</externalid>
        <name>ATF6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338110</externalid>
        <name>MBTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402388</externalid>
        <name>CREB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQ19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-381033</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381070</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381042</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8874177</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8874211</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-381119</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381033</externalid>
    <name>ATF6 (ATF6-alpha) activates chaperones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381033</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341215</externalid>
        <name>MBTPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338055</externalid>
        <name>ATF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338110</externalid>
        <name>MBTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381033</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381070</externalid>
    <name>IRE1alpha activates chaperones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381070</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338077</externalid>
        <name>ERN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381070</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381042</externalid>
    <name>PERK regulates gene expression</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381042</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338063</externalid>
        <name>EIF2AK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D791</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381042</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8874177</externalid>
    <name>ATF6B (ATF6-beta) activates chaperones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8874177</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341215</externalid>
        <name>MBTPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402349</externalid>
        <name>ATF6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338110</externalid>
        <name>MBTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8874177</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8874211</externalid>
    <name>CREB3 factors activate genes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8874211</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10402473</externalid>
        <name>CREBRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341215</externalid>
        <name>MBTPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0III2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402374</externalid>
        <name>CREB3L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338110</externalid>
        <name>MBTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402388</externalid>
        <name>CREB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQ19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8874211</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381119</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9840373</externalid>
    <name>Cellular response to mitochondrial stress</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9840373</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10417135</externalid>
        <name>DELE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405440</externalid>
        <name>PHB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405484</externalid>
        <name>YME1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405480</externalid>
        <name>STOML2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417155</externalid>
        <name>EIF2AK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401273</externalid>
        <name>OMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9840373</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9841251</externalid>
    <name>Mitochondrial unfolded protein response (UPRmt)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9841251</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10372250</externalid>
        <name>DNAJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E954</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329755</externalid>
        <name>FOXO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4K5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335866</externalid>
        <name>ESR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372278</externalid>
        <name>HSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385394</externalid>
        <name>SIRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9841251</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2262752</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9855142</externalid>
    <name>Cellular responses to mechanical stimuli</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9855142</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338002</externalid>
        <name>STAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336235</externalid>
        <name>CALCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>93433</externalid>
        <name>ITGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27977</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336277</externalid>
        <name>RAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CAPNS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343956</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CAPN2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FN1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10335773</externalid>
        <name>ABL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
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          </protein>
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      <gene>
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        <name>CHUK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>GNGT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>GNAQ</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ITGB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
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          </protein>
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      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
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          </protein>
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      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GNB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNB4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
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          </protein>
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      <gene>
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        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ADM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62827</externalid>
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          </protein>
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      <gene>
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        <name>P2RY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>YAP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>Q8WNW7</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>GNG7</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
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          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9860931</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9855142</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953897</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9860931</externalid>
    <name>Response of endothelial cells to shear stress</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9860931</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338002</externalid>
        <name>STAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336235</externalid>
        <name>CALCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>93433</externalid>
        <name>ITGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27977</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336277</externalid>
        <name>RAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316674</externalid>
        <name>PTPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398325</externalid>
        <name>CAPNS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13135</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330530</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343956</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398333</externalid>
        <name>CAPN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27971</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331433</externalid>
        <name>FN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335773</externalid>
        <name>ABL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320321</externalid>
        <name>ITGB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336297</externalid>
        <name>ADM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O62827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336673</externalid>
        <name>P2RY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321951</externalid>
        <name>ANXA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354661</externalid>
        <name>YAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9865249</externalid>
        <name>PDE4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9858797</externalid>
        <name>TRPV4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380230</externalid>
        <name>PKN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760925</externalid>
        <name>FMN(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58210</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929214</externalid>
        <name>sapropterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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    <smallmolecules>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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            </xref>
          </protein>
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      <gene>
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        <name>PEX3</name>
        <entity>
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              <externalid>F1N5H3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ACOX3</name>
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              <externalid>A4IFA4</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>ATAD1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>GSTK1</name>
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          </protein>
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      <gene>
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        <name>SEC61G</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PHYH</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>AGXT</name>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>ATP5F1B</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>CROT</name>
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          </protein>
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      </gene>
      <gene>
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        <name>LONP2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>LOC512541</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BBG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSD17B4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PAOX</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MQP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP5MC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PXMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACOT8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWU6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CAT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00432</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SLC27A2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NOS2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2D1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ABCD2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRNP</name>
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          <protein>
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              <externalid>A0A3Q1M5Z4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VAMP2</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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              <externalid>Q2KIV2</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>MPV17</name>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>COQ2</name>
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          </protein>
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      <gene>
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              <externalid>F1MVP8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>F1MNG5</externalid>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1268020</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9609507</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Mitochondrial protein import</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1268020</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>A0A3Q1MVZ7</externalid>
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          </protein>
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      <gene>
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        <name>TIMM17A</name>
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              <externalid>G3N1S8</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>HSCB</name>
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          <protein>
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              <externalid>F1MLK9</externalid>
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          </protein>
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      <gene>
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        <name>COQ2</name>
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              <externalid>F1N1G6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC25A6</name>
        <entity>
          <protein>
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              <externalid>P32007</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TIMM10</name>
        <entity>
          <protein>
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              <externalid>Q2NKR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408114</externalid>
        <name>LDHD</name>
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          <protein>
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              <externalid>Q148K4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360833</externalid>
        <name>TIMM22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355371</externalid>
        <name>FXN</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q05B87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408134</externalid>
        <name>PITRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323202</externalid>
        <name>ATP5MC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32876</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360841</externalid>
        <name>SLC25A4</name>
        <entity>
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      <smallmolecule>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>cytidine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
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      <smallmolecule>
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        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      <smallmolecule>
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        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
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      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
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      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
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      <smallmolecule>
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        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
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      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
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      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
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      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
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      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
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      <smallmolecule>
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        <name>dioxygen</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69620</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69278</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73886</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1500620</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1640170</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69620</externalid>
    <name>Cell Cycle Checkpoints</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69620</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SGO2</name>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    </biosystemtype>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312623</externalid>
        <name>ATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312561</externalid>
        <name>CHEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69563</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69580</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69563</externalid>
    <name>p53-Dependent G1 DNA Damage Response</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69563</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394637</externalid>
        <name>ZNF385A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QJD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312623</externalid>
        <name>ATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312561</externalid>
        <name>CHEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69541</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69560</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69563</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69580</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69541</externalid>
    <name>Stabilization of p53</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69541</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312623</externalid>
        <name>ATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312561</externalid>
        <name>CHEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-349425</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69541</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69563</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-349425</externalid>
    <name>Autodegradation of the E3 ubiquitin ligase COP1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-349425</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312623</externalid>
        <name>ATM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-349425</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69541</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69560</externalid>
    <name>Transcriptional activation of p53 responsive genes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69560</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394637</externalid>
        <name>ZNF385A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QJD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69895</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69560</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69563</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69895</externalid>
    <name>Transcriptional  activation of  cell cycle inhibitor p21</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69895</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394637</externalid>
        <name>ZNF385A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QJD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69895</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69560</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69613</externalid>
    <name>p53-Independent G1/S DNA Damage Checkpoint</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69613</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420206</externalid>
        <name>NEK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312358</externalid>
        <name>CDC25A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312561</externalid>
        <name>CHEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337662</externalid>
        <name>CSNK1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394594</externalid>
        <name>PLK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69601</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69613</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69601</externalid>
    <name>Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69601</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420206</externalid>
        <name>NEK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312358</externalid>
        <name>CDC25A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312561</externalid>
        <name>CHEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337662</externalid>
        <name>CSNK1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328438</externalid>
        <name>CSNK1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67827</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394594</externalid>
        <name>PLK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69601</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69613</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69481</externalid>
    <name>G2/M Checkpoints</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69481</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>CLSPN</name>
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          <protein>
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              <externalid>A0A3Q1LF69</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316895</externalid>
        <name>YWHAQ</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC2</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MVR8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
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              <externalid>E1BPK0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312606</externalid>
        <name>MRE11</name>
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              <externalid>E1BIN9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
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              <externalid>F1N6W8</externalid>
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          </protein>
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      <gene>
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        <name>RPA3</name>
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          </protein>
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      <gene>
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        <name>RAD9B</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>MCM6</name>
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          </protein>
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      <gene>
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        <name>RNF8</name>
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      <gene>
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      <gene>
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        <name>PIAS4</name>
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      <gene>
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        <name>KAT5</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MCM7</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BDE9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ATM</name>
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          <protein>
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              <externalid>E1BEI6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          </protein>
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      <gene>
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        <name>YWHAH</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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        <name>ATRIP</name>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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        <entity>
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          </protein>
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          </protein>
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        <entity>
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          </protein>
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              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>E1BI26</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMB4</name>
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          </protein>
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          </protein>
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      </gene>
      <gene>
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        <name>H2B</name>
        <entity>
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              <externalid>Q32S29</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>RAD17</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
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        <name>zinc(2+)</name>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69473</externalid>
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      </linkedsystem>
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      <gene>
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        <name>PKMYT1</name>
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          <protein>
            <xref>
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              <externalid>F1MKK7</externalid>
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      <gene>
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        <name>CCNB1</name>
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              <externalid>Q1LZG6</externalid>
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      <gene>
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        <name>CCNA2</name>
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              <externalid>G8JKW1</externalid>
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          </protein>
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      </gene>
    </genes>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69478</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69481</externalid>
        <linkedsystemtype>
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  </biosystem>
  <biosystem>
    <externalid>R-BTA-176187</externalid>
    <name>Activation of ATR in response to replication stress</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-176187</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325754</externalid>
        <name>CLSPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LF69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311512</externalid>
        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325701</externalid>
        <name>RAD17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325743</externalid>
        <name>RAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325719</externalid>
        <name>ATR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311520</externalid>
        <name>ORC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325733</externalid>
        <name>RAD9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311917</externalid>
        <name>DBF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311935</externalid>
        <name>MCM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311913</externalid>
        <name>CDC7L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311542</externalid>
        <name>ORC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325715</externalid>
        <name>ATRIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325739</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325729</externalid>
        <name>RAD9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPW0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311947</externalid>
        <name>MCM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312228</externalid>
        <name>RFC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311931</externalid>
        <name>MCM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFZ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311528</externalid>
        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311951</externalid>
        <name>MCM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311923</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1M8P0</externalid>
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          </protein>
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      <gene>
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        <name>MCM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N506</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
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      <gene>
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        <entity>
          <protein>
            <xref>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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    </genes>
    <smallmolecules>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69481</externalid>
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      </linkedsystem>
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  <biosystem>
    <externalid>R-BTA-69618</externalid>
    <name>Mitotic Spindle Checkpoint</name>
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    </biosystemtype>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>E1BLA0</externalid>
            </xref>
          </protein>
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      <gene>
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          <protein>
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              <externalid>F1MT24</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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              <externalid>F1N0Y3</externalid>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PPP2R5D</name>
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      <gene>
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        <name>CENPK</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>PPP2R5A</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A2VDZ0</externalid>
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          </protein>
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      <gene>
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            <xref>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5EA49</externalid>
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          </protein>
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      <gene>
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        <name>DSN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ81</externalid>
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          </protein>
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      <gene>
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        <name>PAFAH1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P3</externalid>
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          </protein>
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      <gene>
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        <entity>
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      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29606</externalid>
        <name>methanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17790</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-453279</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69242</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-453274</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68886</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-453276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69278</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1640170</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-453279</externalid>
    <name>Mitotic G1 phase and G1/S transition</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-453279</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10355333</externalid>
        <name>LIN54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326798</externalid>
        <name>E2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326305</externalid>
        <name>CDKN2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311935</externalid>
        <name>MCM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353774</externalid>
        <name>E2F4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353805</externalid>
        <name>RBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326716</externalid>
        <name>CKS1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311923</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312351</externalid>
        <name>CABLES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311551</externalid>
        <name>CDC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1Y7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311901</externalid>
        <name>CDC45</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335773</externalid>
        <name>ABL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312430</externalid>
        <name>CDK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326309</externalid>
        <name>CDKN2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
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              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
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            </xref>
          </protein>
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      <gene>
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        <name>RPS27A</name>
        <entity>
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          </protein>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <gene>
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      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1Y7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69231</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69236</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-453279</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69231</externalid>
    <name>Cyclin D associated events in G1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69231</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312447</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N997</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335773</externalid>
        <name>ABL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326798</externalid>
        <name>E2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353788</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353778</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312430</externalid>
        <name>CDK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326309</externalid>
        <name>CDKN2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312415</externalid>
        <name>CCND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326305</externalid>
        <name>CDKN2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353784</externalid>
        <name>TFDP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320038</externalid>
        <name>LOC132342097</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9K6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370449</externalid>
        <name>E2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353774</externalid>
        <name>E2F4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353805</externalid>
        <name>RBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326716</externalid>
        <name>CKS1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326802</externalid>
        <name>E2F3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312419</externalid>
        <name>CCND2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1Y7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9754119</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69231</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69236</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9754119</externalid>
    <name>Drug-mediated inhibition of CDK4/CDK6 activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9754119</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312419</externalid>
        <name>CCND2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312415</externalid>
        <name>CCND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312430</externalid>
        <name>CDK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9754119</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69231</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69206</externalid>
    <name>G1/S Transition</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69206</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311862</externalid>
        <name>POLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311927</externalid>
        <name>MCM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N506</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311570</externalid>
        <name>CDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311557</externalid>
        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69202</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68962</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-113510</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69206</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-453279</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69202</externalid>
    <name>Cyclin E associated events during G1/S transition</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69202</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312358</externalid>
        <name>CDC25A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326716</externalid>
        <name>CKS1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312346</externalid>
        <name>WEE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312351</externalid>
        <name>CABLES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-187577</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69200</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69202</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-187577</externalid>
    <name>SCF(Skp2)-mediated degradation of p27/p21</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-187577</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326716</externalid>
        <name>CKS1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-187577</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69656</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69200</externalid>
    <name>Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69200</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69200</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-68962</externalid>
    <name>Activation of the pre-replicative complex</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68962</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311512</externalid>
        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311858</externalid>
        <name>POLE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311520</externalid>
        <name>ORC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311917</externalid>
        <name>DBF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311935</externalid>
        <name>MCM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311913</externalid>
        <name>CDC7L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311542</externalid>
        <name>ORC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311870</externalid>
        <name>POLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311947</externalid>
        <name>MCM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311931</externalid>
        <name>MCM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311528</externalid>
        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311951</externalid>
        <name>MCM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311866</externalid>
        <name>POLE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311862</externalid>
        <name>POLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311566</externalid>
        <name>GMNN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311923</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311927</externalid>
        <name>MCM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N506</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311557</externalid>
        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311570</externalid>
        <name>CDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311551</externalid>
        <name>CDC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311901</externalid>
        <name>CDC45</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311500</externalid>
        <name>ORC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-68962</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69002</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-113510</externalid>
    <name>E2F mediated regulation of DNA replication</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-113510</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
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        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC132342097</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9K6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-113501</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-113510</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69206</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Inhibition of replication initiation of damaged DNA by RB1/E2F1</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-113501</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>RB1</name>
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          <protein>
            <xref>
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              <externalid>F1MD46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320038</externalid>
        <name>LOC132342097</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9K6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-113501</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-113510</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69242</externalid>
    <name>S Phase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69242</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325898</externalid>
        <name>GINS3</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311947</externalid>
        <name>MCM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312358</externalid>
        <name>CDC25A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311642</externalid>
        <name>CDC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311528</externalid>
        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311951</externalid>
        <name>MCM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358956</externalid>
        <name>RAD21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312346</externalid>
        <name>WEE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311566</externalid>
        <name>GMNN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358990</externalid>
        <name>CDCA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311500</externalid>
        <name>ORC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311512</externalid>
        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358960</externalid>
        <name>STAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358968</externalid>
        <name>SMC1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311870</externalid>
        <name>POLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311931</externalid>
        <name>MCM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358964</externalid>
        <name>STAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311866</externalid>
        <name>POLE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311557</externalid>
        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325890</externalid>
        <name>GINS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358999</externalid>
        <name>WAPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69656</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69239</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75815</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2468052</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69242</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69278</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69656</externalid>
    <name>Cyclin A:Cdk2-associated events at S phase entry</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69656</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312443</externalid>
        <name>CDKN1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312358</externalid>
        <name>CDC25A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324329</externalid>
        <name>CDC25B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326716</externalid>
        <name>CKS1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312346</externalid>
        <name>WEE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312351</externalid>
        <name>CABLES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312439</externalid>
        <name>CDKN1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398082</externalid>
        <name>PTK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>Q3ZCK9</externalid>
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          </protein>
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      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
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              <externalid>Q2KJ25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>F1MYH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD11</name>
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              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A7MB09</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
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          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-187577</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69656</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69242</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69239</externalid>
    <name>Synthesis of DNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69239</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>POLD3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325898</externalid>
        <name>GINS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
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      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311870</externalid>
        <name>POLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311931</externalid>
        <name>MCM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311866</externalid>
        <name>POLE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311557</externalid>
        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325890</externalid>
        <name>GINS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-68952</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69052</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69190</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69239</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69242</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69306</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-68952</externalid>
    <name>DNA replication initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68952</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311858</externalid>
        <name>POLE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311866</externalid>
        <name>POLE3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311862</externalid>
        <name>POLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311870</externalid>
        <name>POLE4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-68952</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69239</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69052</externalid>
    <name>Switching of origins to a post-replicative state</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69052</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311662</externalid>
        <name>ANAPC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311646</externalid>
        <name>ANAPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311520</externalid>
        <name>ORC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311935</externalid>
        <name>MCM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311947</externalid>
        <name>MCM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311528</externalid>
        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MCM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311566</externalid>
        <name>GMNN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CDC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311512</externalid>
        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ANAPC4</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>UBE2D1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMD13</name>
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            <xref>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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            <xref>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBB</name>
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      <gene>
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      <gene>
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        <name>RPS27A</name>
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    <smallmolecules>
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      <smallmolecule>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-69239</externalid>
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    <name>Orc1 removal from chromatin</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68949</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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      <gene>
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              <externalid>F1MXE4</externalid>
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      <gene>
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        <name>PSMC3</name>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
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        <name>CCNA1</name>
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              <externalid>F1MVR8</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC3</name>
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              <externalid>F1N6W8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC4</name>
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              <externalid>Q2YDI2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>MCM6</name>
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              <externalid>E1BH89</externalid>
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          </protein>
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      <gene>
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        <name>PSMC1</name>
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              <externalid>A4FUZ3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311947</externalid>
        <name>MCM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311528</externalid>
        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311951</externalid>
        <name>MCM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311551</externalid>
        <name>CDC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311500</externalid>
        <name>ORC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311512</externalid>
        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311542</externalid>
        <name>ORC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311931</externalid>
        <name>MCM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311927</externalid>
        <name>MCM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N506</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311570</externalid>
        <name>CDT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
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              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD8</name>
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          <protein>
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              <externalid>F1MYH8</externalid>
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          </protein>
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      <gene>
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        <name>PSMD11</name>
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          </protein>
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      <gene>
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        <name>SKP2</name>
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              <externalid>A7MB09</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-68949</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69052</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69017</externalid>
    <name>CDK-mediated phosphorylation and removal of Cdc6</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69017</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>CDK2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311662</externalid>
        <name>ANAPC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311646</externalid>
        <name>ANAPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312148</externalid>
        <name>CCNE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311642</externalid>
        <name>CDC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311551</externalid>
        <name>CDC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312144</externalid>
        <name>CCNE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311676</externalid>
        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69017</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69052</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69190</externalid>
    <name>DNA strand elongation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69190</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325898</externalid>
        <name>GINS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312228</externalid>
        <name>RFC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325902</externalid>
        <name>GINS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312224</externalid>
        <name>RFC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325894</externalid>
        <name>GINS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325890</externalid>
        <name>GINS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-176974</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69109</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69186</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69190</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69239</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-176974</externalid>
    <name>Unwinding of DNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-176974</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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        <name>GINS3</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-HSA-176974</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          <protein>
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          <protein>
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      <gene>
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          <protein>
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      <smallmolecule>
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      <linkedsystem>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
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        <name>uridine 5'-monophosphate(2-)</name>
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          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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          <externalid>456215</externalid>
        </xref>
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      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
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          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69183</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69166</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69183</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69186</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69166</externalid>
    <name>Removal of the Flap Intermediate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69166</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-69166</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69183</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75815</externalid>
    <name>Ubiquitin-dependent degradation of Cyclin D</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75815</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312425</externalid>
        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC4</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD8</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
          <protein>
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              <externalid>Q3ZBG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
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              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75815</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69242</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ESCO1</name>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97593</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ESCO2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QNP8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMC3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>CDCA5</name>
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          </protein>
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      <gene>
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        <name>PDS5B</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>acetyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-2468052</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBC</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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        <name>HAUS5</name>
        <entity>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>ODF2</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>CLASP1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>HAUS4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PPP1CB</name>
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          </protein>
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      </gene>
      <gene>
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        <name>PCNT</name>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>DCTN1</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSP90AA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTC8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SSNA1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9C3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CKAP5</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>CDK5RAP2</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          <protein>
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              <externalid>E1BNG7</externalid>
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          </protein>
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              <externalid>Q2TA25</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CEP76</name>
        <entity>
          <protein>
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              <externalid>E1B8D7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TUBA1A</name>
        <entity>
          <protein>
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              <externalid>F2Z4C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HAUS1</name>
        <entity>
          <protein>
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              <externalid>Q2TBK4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CEP70</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1ME79</externalid>
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          </protein>
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      <gene>
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        <name>PCM1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>TUBG2</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PRKAR2B</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NEDD1</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CDK11B</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CLASP1</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA4</externalid>
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          </protein>
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      <gene>
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        <name>PCNT</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PAFAH1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P3</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPA7</externalid>
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          </protein>
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      <gene>
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        <name>CEP27</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <smallmolecule>
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      <linkedsystem>
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    <name>Recruitment of mitotic centrosome proteins and complexes</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-380270</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>F1MNN1</externalid>
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              <externalid>A7Z057</externalid>
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        <name>CCP110</name>
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              <externalid>E1BGQ5</externalid>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>NEDD1</name>
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          </protein>
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      <gene>
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        <name>CEP164</name>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>HAUS5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ODF2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MAPRE1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>CLASP1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>HAUS4</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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          </protein>
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        <name>CDK5RAP2</name>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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        <name>SFI1</name>
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      <gene>
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        <name>CEP250</name>
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        <name>PLK4</name>
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      <gene>
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        <name>YWHAE</name>
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      <gene>
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        <name>CEP43</name>
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    </genes>
    <smallmolecules>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-380259</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-380284</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-380287</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-380259</externalid>
    <name>Loss of Nlp from mitotic centrosomes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-380259</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>TUBG1</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <name>HAUS6</name>
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              <externalid>E1BG87</externalid>
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          </protein>
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        <name>SDCCAG8</name>
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              <externalid>E1BKZ3</externalid>
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        <name>CEP131</name>
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              <externalid>A0A3Q1M407</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>HAUS3</name>
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              <externalid>F1MNN1</externalid>
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          </protein>
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              <externalid>A7Z057</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCP110</name>
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              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB5</name>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBC</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD14</name>
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              <externalid>Q17QP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>TP53</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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        <name>CETN2</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>PCNT</name>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DCTN1</name>
        <entity>
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            <xref>
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              <externalid>A0A3Q1M3Y3</externalid>
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      <smallmolecule>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321360</externalid>
        <name>CENPH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-68875</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68877</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2555396</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68884</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-68886</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69278</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-68875</externalid>
    <name>Mitotic Prophase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68875</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>MASTL</name>
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          </protein>
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      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
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              <externalid>A7YY75</externalid>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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        <name>CCNB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <externalid>E1B8P9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>RB1</name>
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      <gene>
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        <name>LOC528006</name>
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              <externalid>Q0VBX4</externalid>
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          </protein>
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      <gene>
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        <name>POM121C</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NUP50</name>
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      <gene>
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      <gene>
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        <name>SET</name>
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              <externalid>Q2TBR3</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>CDK1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        </entity>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>EMD</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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              <externalid>F1MPW7</externalid>
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          </protein>
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      <gene>
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        <name>NUP205</name>
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          </protein>
        </entity>
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      <gene>
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        <name>GORASP1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>LMNB1</name>
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          <protein>
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              <externalid>A7YY47</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP133</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RAB1B</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MWA3</externalid>
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          </protein>
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              <externalid>Q3ZC98</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
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          </protein>
        </entity>
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        <name>NUP88</name>
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              <externalid>Q3SZ56</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP35</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-162658</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2299718</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2465910</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980766</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-68875</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68886</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-162658</externalid>
    <name>Golgi Cisternae Pericentriolar Stack Reorganization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-162658</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10367764</externalid>
        <name>GORASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366926</externalid>
        <name>GORASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366933</externalid>
        <name>GOLGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366938</externalid>
        <name>RAB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367772</externalid>
        <name>RAB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367768</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NNB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-162658</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68875</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2299718</externalid>
    <name>Condensation of Prophase Chromosomes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2299718</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366373</externalid>
        <name>SMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345114</externalid>
        <name>SET</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367139</externalid>
        <name>KMT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366385</externalid>
        <name>NCAPG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N535</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367950</externalid>
        <name>MCPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366389</externalid>
        <name>NCAPH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366420</externalid>
        <name>PHF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366377</externalid>
        <name>SMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312776</externalid>
        <name>H3-4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>HIST1H2BI</name>
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      <gene>
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        <name>H2AC6</name>
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      <gene>
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        <name>NCAPD3</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>dioxygen</name>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>2-oxoglutarate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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        <name>iron(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>formaldehyde</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-2299718</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68875</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>MASTL Facilitates Mitotic Progression</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <gene>
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      <smallmolecule>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Nuclear Envelope Breakdown</name>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
        </entity>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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          <protein>
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          </protein>
        </entity>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
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        <name>RAE1</name>
        <entity>
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          </protein>
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        <name>NUP54</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBM39</name>
        <entity>
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          </protein>
        </entity>
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        <entity>
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          </protein>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369819</externalid>
        <name>EMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317573</externalid>
        <name>LPIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369858</externalid>
        <name>VRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317127</externalid>
        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2980767</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3301854</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4419969</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2980766</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68875</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2980767</externalid>
    <name>Activation of NIMA Kinases NEK9, NEK6, NEK7</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2980767</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10369593</externalid>
        <name>NEK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369587</externalid>
        <name>NEK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324249</externalid>
        <name>CCNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T859</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369583</externalid>
        <name>NEK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2980767</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3301854</externalid>
    <name>Nuclear Pore Complex (NPC) Disassembly</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10317121</externalid>
        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369587</externalid>
        <name>NEK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324249</externalid>
        <name>CCNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T859</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369583</externalid>
        <name>NEK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317131</externalid>
        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317159</externalid>
        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369593</externalid>
        <name>NEK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317163</externalid>
        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5E9A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317117</externalid>
        <name>NUP54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317127</externalid>
        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3301854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4419969</externalid>
    <name>Depolymerization of the Nuclear Lamina</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10317565</externalid>
        <name>LPIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374781</externalid>
        <name>CTDNEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369823</externalid>
        <name>RBM39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333864</externalid>
        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>CDK1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EMD</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SX08</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CCNB1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
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          </protein>
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      <gene>
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        <name>LPIN3</name>
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              <externalid>E1BLQ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374785</externalid>
        <name>CNEP1R1</name>
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          <protein>
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              <externalid>Q3ZBP2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LPIN2</name>
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          <protein>
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              <externalid>E1BCN1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316257</externalid>
        <name>1,2-diacyl-sn-glycerol 3-phosphate(2-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4419969</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980766</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-68877</externalid>
    <name>Mitotic Prometaphase</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68877</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SGO2</name>
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              <externalid>E1BLA0</externalid>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>XPO1</name>
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              <externalid>E1BE98</externalid>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>F1N0Y3</externalid>
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          </protein>
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      <gene>
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        <name>CENPQ</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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    <name>Resolution of Sister Chromatid Cohesion</name>
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            </xref>
          </protein>
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      <gene>
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        <name>PPP2R5C</name>
        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321432</externalid>
        <name>CDCA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321328</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250593</externalid>
        <name>TUBA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321312</externalid>
        <name>CENPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321180</externalid>
        <name>CLASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321364</externalid>
        <name>CENPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAOK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ19</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321474</externalid>
        <name>ERCC6L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KNTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDEL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N184</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369583</externalid>
        <name>NEK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7J4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321460</externalid>
        <name>ZWILCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321292</externalid>
        <name>CKAP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321218</externalid>
        <name>SGO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321280</externalid>
        <name>PPP1CC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61287</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SKA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZW10</name>
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          <protein>
            <xref>
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              <externalid>Q0P5L6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPS</name>
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          <protein>
            <xref>
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              <externalid>Q2TBR7</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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    <smallmolecules>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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    </smallmolecules>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68877</externalid>
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    </linkedsystems>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2555396</url>
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      <taxnode>
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      <gene>
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      <gene>
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              <externalid>Q1RML1</externalid>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1N1S8</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>A4FUZ3</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>A6QLW0</externalid>
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      <gene>
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              <externalid>P67774</externalid>
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        </entity>
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      <gene>
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        <name>MAPRE1</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R5A</name>
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          <protein>
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              <externalid>A2VDZ0</externalid>
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          </protein>
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      <gene>
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        <name>EMD</name>
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              <externalid>Q3SX08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>G3N089</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1MBI1</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PPP2CB</name>
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              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RCC2</name>
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              <externalid>A6QL85</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RANGAP1</name>
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              <externalid>F1MFD5</externalid>
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          </protein>
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      <gene>
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        <name>TUBB6</name>
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              <externalid>Q2HJ81</externalid>
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      <gene>
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        <name>LMNB1</name>
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              <externalid>A7YY47</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CHMP3</name>
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              <externalid>Q58CS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP85</name>
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              <externalid>Q3ZC98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321398</externalid>
        <name>NUF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369909</externalid>
        <name>ANKLE2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
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              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC16</name>
        <entity>
          <protein>
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              <externalid>Q58DR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC5</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SPAST</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>SKA1</name>
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              <externalid>A0A3Q1NEK5</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ZW10</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L6</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MXJ5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPS</name>
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              <externalid>Q2TBR7</externalid>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>Q3ZCC9</externalid>
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      <gene>
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              <externalid>Q2KI42</externalid>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>coenzyme A(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>nicotinamide</name>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
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      <smallmolecule>
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      <linkedsystem>
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      </linkedsystem>
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      <gene>
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              <externalid>Q0P594</externalid>
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          </protein>
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      <gene>
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        <name>RCC2</name>
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        </entity>
      </gene>
      <gene>
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      </gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4IFM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321328</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250593</externalid>
        <name>TUBA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321364</externalid>
        <name>CENPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321478</externalid>
        <name>TAOK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412391</externalid>
        <name>SPAST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDN5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERCC6L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZWILCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358960</externalid>
        <name>STAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC39</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358968</externalid>
        <name>SMC1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321226</externalid>
        <name>SKA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358964</externalid>
        <name>STAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321464</externalid>
        <name>ZW10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392911</externalid>
        <name>IST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321324</externalid>
        <name>CENPS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321402</externalid>
        <name>SPC24</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L1</externalid>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
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          </protein>
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      <gene>
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        <name>PSMD11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2467813</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2995410</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-68882</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2555396</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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    <name>Separation of Sister Chromatids</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2467813</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>SGO2</name>
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          <protein>
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              <externalid>E1BLA0</externalid>
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      <gene>
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              <externalid>F1MT24</externalid>
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          </protein>
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      <gene>
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        <name>XPO1</name>
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              <externalid>E1BE98</externalid>
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      <gene>
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        <name>SPC25</name>
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          <protein>
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              <externalid>Q3ZBK3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>9619732</externalid>
        <name>TUBB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321284</externalid>
        <name>KIF2B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N0Y3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPQ</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMC2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>Q3ZBK8</externalid>
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      </gene>
      <gene>
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        <name>PSMC3</name>
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              <externalid>F1MWE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEH1L</name>
        <entity>
          <protein>
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              <externalid>A7YY75</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
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              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPK</name>
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              <externalid>F1MLG9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPE</name>
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          <protein>
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              <externalid>E1BG49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358984</externalid>
        <name>PDS5B</name>
        <entity>
          <protein>
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              <externalid>F1N7G8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
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          <protein>
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              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TUBA1A</name>
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          <protein>
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              <externalid>F2Z4C1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321192</externalid>
        <name>AHCTF1</name>
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          <protein>
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              <externalid>A0A3Q1MMV9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321344</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MTW3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1B</name>
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          <protein>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ANAPC10</name>
        <entity>
          <protein>
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              <externalid>F2Z4G9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321482</externalid>
        <name>DYNC1H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321394</externalid>
        <name>NDC80</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321160</externalid>
        <name>MAD1L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321502</externalid>
        <name>DYNC1LI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321424</externalid>
        <name>AURKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>154751</externalid>
        <name>TUBA4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81948</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321488</externalid>
        <name>DYNC1I1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RQ3</externalid>
            </xref>
          </protein>
        </entity>
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          <protein>
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              <externalid>F1MWP1</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>PPP2R5C</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321168</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E613</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321320</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358956</externalid>
        <name>RAD21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619703</externalid>
        <name>LOC100141266</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321352</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321432</externalid>
        <name>CDCA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFM5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321328</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TUBA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358990</externalid>
        <name>CDCA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPL</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321180</externalid>
        <name>CLASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321364</externalid>
        <name>CENPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321478</externalid>
        <name>TAOK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ19</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321474</externalid>
        <name>ERCC6L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321456</externalid>
        <name>KNTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321210</externalid>
        <name>NDEL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N184</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321460</externalid>
        <name>ZWILCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358960</externalid>
        <name>STAG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMC1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CKAP5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
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          </protein>
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      <gene>
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        <name>PSMC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SGO1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ANAPC1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
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          </protein>
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      <gene>
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        <name>PPP1CC</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
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      <gene>
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        <name>SKA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>STAG2</name>
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          </protein>
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      <gene>
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        <name>ZW10</name>
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              <externalid>Q0P5L6</externalid>
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          </protein>
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      <gene>
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        <name>PSMD12</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
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          </protein>
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      <gene>
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        <name>CENPS</name>
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              <externalid>Q2TBR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP107</name>
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              <externalid>E1BDU0</externalid>
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          </protein>
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      <gene>
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        <name>NUDC</name>
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          </protein>
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      <gene>
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        <name>TUBB4A</name>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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        <name>SPC24</name>
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              <externalid>F1MNP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC8</name>
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          <protein>
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              <externalid>A0A3Q1MDJ2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CENPH</name>
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              <externalid>Q3T0L1</externalid>
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      <gene>
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        <name>RPS27A</name>
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              <externalid>P62992</externalid>
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      <gene>
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        <name>SEC13</name>
        <entity>
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              <externalid>Q3ZCC9</externalid>
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          </protein>
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      <gene>
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        <name>PSMD11</name>
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              <externalid>Q2KI42</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WAPL</name>
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              <externalid>E1BGC3</externalid>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
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          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2467813</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68882</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2995410</externalid>
    <name>Nuclear Envelope (NE) Reassembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2995410</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10324249</externalid>
        <name>CCNB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T859</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348621</externalid>
        <name>CHMP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321192</externalid>
        <name>AHCTF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333864</externalid>
        <name>LMNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348615</externalid>
        <name>CHMP4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369829</externalid>
        <name>BANF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61283</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348597</externalid>
        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328413</externalid>
        <name>LBR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369823</externalid>
        <name>RBM39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411062</externalid>
        <name>RCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369819</externalid>
        <name>EMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348625</externalid>
        <name>CHMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H704</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348607</externalid>
        <name>CHMP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412391</externalid>
        <name>SPAST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369862</externalid>
        <name>VRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N078</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321214</externalid>
        <name>RANGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348603</externalid>
        <name>CHMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369909</externalid>
        <name>ANKLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H744</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348697</externalid>
        <name>VPS4A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8E2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412370</externalid>
        <name>SIRT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QK60</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392911</externalid>
        <name>IST1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXJ5</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
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          </protein>
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      <gene>
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        <name>SEC13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
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          </protein>
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      <gene>
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        <name>RAN</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CC2D1B</name>
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          <protein>
            <xref>
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              <externalid>F1N7R5</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2995383</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9615933</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9668328</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2995410</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68882</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2995383</externalid>
    <name>Initiation of Nuclear Envelope (NE) Reformation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2995383</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>LMNA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369829</externalid>
        <name>BANF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61283</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324249</externalid>
        <name>CCNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T859</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369862</externalid>
        <name>VRK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N078</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412370</externalid>
        <name>SIRT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QK60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328413</externalid>
        <name>LBR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369823</externalid>
        <name>RBM39</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333885</externalid>
        <name>LMNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369909</externalid>
        <name>ANKLE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369819</externalid>
        <name>EMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369858</externalid>
        <name>VRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2995383</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2995410</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9615933</externalid>
    <name>Postmitotic nuclear pore complex (NPC) reformation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9615933</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321214</externalid>
        <name>RANGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317189</externalid>
        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411062</externalid>
        <name>RCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321192</externalid>
        <name>AHCTF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331733</externalid>
        <name>RAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T054</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H744</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9615933</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2995410</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9668328</externalid>
    <name>Sealing of the nuclear envelope (NE) by ESCRT-III</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9668328</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348625</externalid>
        <name>CHMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H704</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392911</externalid>
        <name>IST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348607</externalid>
        <name>CHMP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348603</externalid>
        <name>CHMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348615</externalid>
        <name>CHMP4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412391</externalid>
        <name>SPAST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348621</externalid>
        <name>CHMP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348697</externalid>
        <name>VPS4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8E2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348597</externalid>
        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412395</externalid>
        <name>CC2D1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2995410</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-68884</externalid>
    <name>Mitotic Telophase/Cytokinesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68884</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>KIF20A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321561</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358964</externalid>
        <name>STAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358956</externalid>
        <name>RAD21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368352</externalid>
        <name>NIPBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358960</externalid>
        <name>STAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358968</externalid>
        <name>SMC1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97593</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368348</externalid>
        <name>MAU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358972</externalid>
        <name>SMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z065</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358984</externalid>
        <name>PDS5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PDS5A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKG4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WAPL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGC3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2470946</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-68884</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68886</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2470946</externalid>
    <name>Cohesin Loading onto Chromatin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2470946</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358960</externalid>
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              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311676</externalid>
        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-174143</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-453276</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69278</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174143</externalid>
    <name>APC/C-mediated degradation of cell cycle proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174143</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311662</externalid>
        <name>ANAPC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311646</externalid>
        <name>ANAPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321450</externalid>
        <name>CDC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325044</externalid>
        <name>AURKA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312365</externalid>
        <name>RB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311642</externalid>
        <name>CDC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321442</externalid>
        <name>BUB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321424</externalid>
        <name>AURKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326259</externalid>
        <name>NEK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321438</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325113</externalid>
        <name>CDC14A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325040</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N089</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321446</externalid>
        <name>BUB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322450</externalid>
        <name>FBXO5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5V7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311676</externalid>
        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-176408</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-176814</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-176407</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174178</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174084</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-174143</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-453276</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-176408</externalid>
    <name>Regulation of APC/C activators between G1/S and early anaphase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-176408</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311662</externalid>
        <name>ANAPC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311646</externalid>
        <name>ANAPC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321450</externalid>
        <name>CDC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321446</externalid>
        <name>BUB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322450</externalid>
        <name>FBXO5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5V7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311642</externalid>
        <name>CDC16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321442</externalid>
        <name>BUB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312027</externalid>
        <name>CUL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311676</externalid>
        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321438</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-176417</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174113</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-141405</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-176408</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174143</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-176417</externalid>
    <name>Phosphorylation of Emi1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-176417</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321450</externalid>
        <name>CDC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324208</externalid>
        <name>CCNB1</name>
        <entity>
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          </protein>
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      <gene>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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        </xref>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-176417</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-176408</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>UBC</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CUL1</name>
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      <gene>
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          <linked />
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      <linkedsystem>
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          <superset />
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  <biosystem>
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      <taxnode>
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          </protein>
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        </entity>
      </gene>
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        <name>PSMD12</name>
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              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC4</name>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
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              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-BTA-176412</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-176409</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-176814</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174143</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>CDC16</name>
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              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC16</name>
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          <protein>
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              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
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          <protein>
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              <externalid>Q32PA5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNB1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
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          <protein>
            <xref>
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              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321276</externalid>
        <name>PLK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <linkedsystem>
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      <linkedsystem>
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          <superset />
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      </linkedsystem>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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        <name>PSMD6</name>
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              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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          <protein>
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          </protein>
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      <gene>
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              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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          <protein>
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          </protein>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
        <entity>
          <protein>
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              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
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          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD2</name>
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          <protein>
            <xref>
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              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB7</name>
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          <protein>
            <xref>
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              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325040</externalid>
        <entity>
          <protein>
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              <externalid>G3N089</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC26</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC5</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BUB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB5</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311622</externalid>
        <name>ANAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
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      <gene>
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        <name>UBE2C</name>
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          </protein>
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      <gene>
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        <name>PSMB4</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMA4</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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      <gene>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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      <gene>
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    </genes>
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      <linkedsystem>
        <externalid>R-BTA-179419</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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  <biosystem>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-179419</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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              <externalid>E1BM34</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>CDC20</name>
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          <protein>
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          </protein>
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      <gene>
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              <externalid>F1MVR8</externalid>
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      <gene>
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          </protein>
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              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>CDC23</name>
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          <protein>
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              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>PSMC1</name>
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          <protein>
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              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
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              <externalid>A1L5A6</externalid>
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          </protein>
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      <gene>
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              <externalid>F2Z4G9</externalid>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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          </protein>
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      <gene>
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        <name>CDC16</name>
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              <externalid>E1BPM5</externalid>
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          </protein>
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      <gene>
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              <externalid>Q2KJ46</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>BUB1B</name>
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              <externalid>F1MWP1</externalid>
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          </protein>
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      <gene>
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        <name>PSMA1</name>
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              <externalid>Q3T0X5</externalid>
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          </protein>
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      <gene>
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        <name>PSMA6</name>
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              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNA2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
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          </protein>
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      <gene>
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        <name>PSMB3</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC5</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NEK2</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC15</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <externalid>G3MX31</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB7</name>
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              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC26</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC16</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58DR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321446</externalid>
        <name>BUB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>UBE2D1</name>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD7</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>Q5E964</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311626</externalid>
        <name>ANAPC2</name>
        <entity>
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            <xref>
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              <externalid>G3N1P6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC1</name>
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            </xref>
          </protein>
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      <gene>
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        <name>PSMD14</name>
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      <gene>
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      <gene>
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      <linkedsystem>
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      <linkedsystem>
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    </biosystemtype>
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      <taxnode>
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      <gene>
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              <externalid>A4FUZ3</externalid>
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      <gene>
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        <name>CCNA2</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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            </xref>
          </protein>
        </entity>
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          </protein>
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          </protein>
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          </protein>
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        <name>UBE2C</name>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311650</externalid>
        <name>CDC23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311642</externalid>
        <name>CDC16</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311684</externalid>
        <name>ANAPC15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325040</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N089</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311668</externalid>
        <name>CDC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311688</externalid>
        <name>ANAPC16</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311638</externalid>
        <name>ANAPC5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311634</externalid>
        <name>ANAPC4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>356312</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>244104</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311783</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311622</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>9918619</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174154</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-176409</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-176407</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2S</name>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q3ZCF6</externalid>
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          </protein>
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      <gene>
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        <name>ANAPC7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BM34</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321450</externalid>
        <name>CDC20</name>
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              <externalid>F1MRW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B945</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311630</externalid>
        <name>CDC27</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7Z061</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC15</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDC23</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A1A4R8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N1P6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2E1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ANAPC1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311658</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M862</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325113</externalid>
        <name>CDC14A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR2</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-176407</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174143</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>ANAPC10</name>
        <entity>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CDC16</name>
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          </protein>
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      <gene>
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        <name>PSMD3</name>
        <entity>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322536</externalid>
        <name>ANKRD28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346872</externalid>
        <name>RUVBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312776</externalid>
        <name>H3-4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315816</externalid>
        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346854</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321324</externalid>
        <name>CENPS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325299</externalid>
        <name>STN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB2</externalid>
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          </protein>
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      <gene>
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        <name>CENPH</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>POLD2</name>
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          <protein>
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          </protein>
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      <gene>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-73886</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1640170</externalid>
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      </linkedsystem>
    </linkedsystems>
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    <name>Nucleosome assembly</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-774815</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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              <externalid>E1B896</externalid>
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      <gene>
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      <gene>
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        <name>MIS18A</name>
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              <externalid>A5D7N9</externalid>
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      <gene>
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              <externalid>E1BMQ3</externalid>
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      <gene>
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              <externalid>G3N1G0</externalid>
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      <gene>
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        <name>CENPQ</name>
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              <externalid>Q08DW5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CENPO</name>
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              <externalid>Q3ZBK8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>E1BPK0</externalid>
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          </protein>
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      <gene>
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        <name>CENPK</name>
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          <protein>
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              <externalid>F1MLG9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>A0A3Q1M6A8</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312708</externalid>
        <entity>
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              <externalid>G3N011</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMARCA5</name>
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          <protein>
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              <externalid>F1N052</externalid>
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          </protein>
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      <gene>
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        <name>LOC528006</name>
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          <protein>
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              <externalid>Q0VBX4</externalid>
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          </protein>
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      <gene>
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        <name>KNL1</name>
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          <protein>
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              <externalid>A0A3Q1M302</externalid>
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          </protein>
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      <gene>
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        <name>NPM1</name>
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              <externalid>F1MTV9</externalid>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MTW3</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1LXL7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E613</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321352</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346862</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321328</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321312</externalid>
        <name>CENPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321364</externalid>
        <name>CENPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
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        <externalid>10321312</externalid>
        <name>CENPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321364</externalid>
        <name>CENPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321336</externalid>
        <name>CENPP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321308</externalid>
        <name>CENPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346796</externalid>
        <name>RSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346872</externalid>
        <name>RUVBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346850</externalid>
        <name>HJURP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315816</externalid>
        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OIP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CENPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC6</name>
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              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>CENPH</name>
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            </xref>
          </protein>
        </entity>
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      <gene>
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              <externalid>A8WFK5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>56166</externalid>
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              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-606279</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-774815</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Telomere Maintenance</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-157579</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>POLD3</name>
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              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POT1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PIF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LIG1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322477</externalid>
        <name>NOP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412451</externalid>
        <name>SHQ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312224</externalid>
        <name>RFC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325295</externalid>
        <name>CTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-180786</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-171306</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9670095</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-157579</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73886</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-180786</externalid>
    <name>Extension of Telomeres</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-180786</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322459</externalid>
        <name>TERT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322556</externalid>
        <name>PIF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322469</externalid>
        <name>WRAP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325347</externalid>
        <name>DSCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325339</externalid>
        <name>CHTF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322532</externalid>
        <name>PPP6R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325303</externalid>
        <name>TEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322477</externalid>
        <name>NOP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412451</externalid>
        <name>SHQ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312224</externalid>
        <name>RFC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325295</externalid>
        <name>CTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322473</externalid>
        <name>NHP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E950</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322465</externalid>
        <name>DKC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322517</externalid>
        <name>RTEL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N079</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325343</externalid>
        <name>CHTF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322536</externalid>
        <name>ANKRD28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325326</externalid>
        <name>BLM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312228</externalid>
        <name>RFC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322481</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322540</externalid>
        <name>PPP6C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325299</externalid>
        <name>STN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-171319</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174417</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-180786</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157579</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-171319</externalid>
    <name>Telomere Extension By Telomerase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-171319</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322473</externalid>
        <name>NHP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E950</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311907</externalid>
        <name>CDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322481</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322459</externalid>
        <name>TERT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322556</externalid>
        <name>PIF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322469</externalid>
        <name>WRAP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322540</externalid>
        <name>PPP6C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312002</externalid>
        <name>CCNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322465</externalid>
        <name>DKC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322477</externalid>
        <name>NOP10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322517</externalid>
        <name>RTEL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N079</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412451</externalid>
        <name>SHQ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322536</externalid>
        <name>ANKRD28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322532</externalid>
        <name>PPP6R3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-171319</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-180786</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174417</externalid>
    <name>Telomere C-strand (Lagging Strand) Synthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174417</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325295</externalid>
        <name>CTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325347</externalid>
        <name>DSCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325343</externalid>
        <name>CHTF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325339</externalid>
        <name>CHTF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325326</externalid>
        <name>BLM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312228</externalid>
        <name>RFC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325303</externalid>
        <name>TEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312224</externalid>
        <name>RFC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325299</externalid>
        <name>STN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-174430</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174411</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174414</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-174417</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-180786</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174430</externalid>
    <name>Telomere C-strand synthesis initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174430</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325295</externalid>
        <name>CTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325303</externalid>
        <name>TEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325299</externalid>
        <name>STN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174430</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174417</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174411</externalid>
    <name>Polymerase switching on the C-strand of the telomere</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174411</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325295</externalid>
        <name>CTC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325347</externalid>
        <name>DSCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325343</externalid>
        <name>CHTF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311846</externalid>
        <name>PRIM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312236</externalid>
        <name>RFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N5S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325339</externalid>
        <name>CHTF18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312232</externalid>
        <name>RFC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312228</externalid>
        <name>RFC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311842</externalid>
        <name>POLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325303</externalid>
        <name>TEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312220</externalid>
        <name>RFC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311838</externalid>
        <name>POLA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312224</externalid>
        <name>RFC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325299</externalid>
        <name>STN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174411</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174417</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174414</externalid>
    <name>Processive synthesis on the C-strand of the telomere</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174414</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312318</externalid>
        <name>LIG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325326</externalid>
        <name>BLM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ04</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-174437</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-174414</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174417</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174437</externalid>
    <name>Removal of the Flap Intermediate from the C-strand</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174437</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312268</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312264</externalid>
        <name>POLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84798</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RPJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311895</externalid>
        <name>RPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325330</externalid>
        <name>WRN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312297</externalid>
        <name>DNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322495</externalid>
        <name>TINF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312311</externalid>
        <name>FEN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312272</externalid>
        <name>POLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2143448</externalid>
        <name>polynucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15986</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174437</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174414</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-171306</externalid>
    <name>Packaging Of Telomere Ends</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-171306</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322487</externalid>
        <name>POT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322491</externalid>
        <name>TERF2IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322509</externalid>
        <name>TERF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322503</externalid>
        <name>TERF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322499</externalid>
        <name>ACD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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              <externalid>F1N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
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              <externalid>F1MEU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356218</externalid>
        <name>ABCC5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MZD4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356366</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB23</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325783</externalid>
        <name>SULT1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC30</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321890</externalid>
        <name>UGT2B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFF5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318518</externalid>
        <name>SLC28A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387320</externalid>
        <name>CES2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321987</externalid>
        <name>NAT1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318532</externalid>
        <name>ADK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB39</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML05</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYP2D14</name>
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          <protein>
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              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GGT1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378911</externalid>
        <name>GGT7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325571</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEC8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368456</externalid>
        <name>ITPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315963</externalid>
        <name>GUK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46195</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315983</externalid>
        <name>IMPDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342460</externalid>
        <name>LOC515333</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316371</externalid>
        <name>XDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403439</externalid>
        <name>PON1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328296</externalid>
        <name>ABCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325647</externalid>
        <name>GSTT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325789</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0S6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316355</externalid>
        <name>ADA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325853</externalid>
        <name>LOC100300896</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316341</externalid>
        <name>HPRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ18</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318489</externalid>
        <name>SLC29A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY72</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755047</externalid>
        <name>1,2,4-triazole-3-carboxamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180482</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754727</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749996</externalid>
        <name>2,3-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749980</externalid>
        <name>1-salicylate O-glucuronide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755276</externalid>
        <name>6 thioguanosine triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180688</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753641</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)cysteine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748950</externalid>
        <name>6-Thiourate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757557</externalid>
        <name>6beta-hydroxyprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748948</externalid>
        <name>6-Thioguanosine monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757544</externalid>
        <name>20alpha-dihydroprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>166776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748966</externalid>
        <name>methylthioinosine monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3037883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748964</externalid>
        <name>6-Thioxanthine 5'-monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793627</externalid>
        <name>ciprofloxacin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>192484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754715</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753646</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133435</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754994</externalid>
        <name>ribavirin carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754982</externalid>
        <name>ribavirin 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755270</externalid>
        <name>6 thiodeoxyguanosine diphosphate (3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180690</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749989</externalid>
        <name>2,5-dihydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90176</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757553</externalid>
        <name>20alpha-dihydroprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>182969</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755274</externalid>
        <name>6-Thioxanthine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180685</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755279</externalid>
        <name>6-Thioguanosine diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180687</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166426</externalid>
        <name>acetaminophen O-beta-D-glucosiduronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754724</externalid>
        <name>N-acetyl-L-cysteinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9756758</externalid>
        <name>GS-nitroimidazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9756763</externalid>
        <name>4-hydroxyatorvastatin lactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180934</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753450</externalid>
        <name>N-Acetyl-p-benzoquinonimine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>173517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9750003</externalid>
        <name>Gentisuric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88742</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161179</externalid>
        <name>cyclopropylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34660</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749982</externalid>
        <name>salicylic acyl beta-D-glucuronide (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793567</externalid>
        <name>ciprofloxacin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>192486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755275</externalid>
        <name>6 thiodeoxyguanosine monophosphate (2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757550</externalid>
        <name>20beta-dihydroprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755272</externalid>
        <name>6-thioinosine-5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180684</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162237</externalid>
        <name>abacavir 5'-carboxylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64192</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753782</externalid>
        <name>Paracetamol-Cys-Gly conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749978</externalid>
        <name>2,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114736</externalid>
        <name>phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757543</externalid>
        <name>6beta-hydroxyprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748971</externalid>
        <name>9-(5-phosphoribofuranosyl)-6-mercaptopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757546</externalid>
        <name>20beta-dihydroprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>182970</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754919</externalid>
        <name>ribavirin 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755273</externalid>
        <name>6-thiodeoxyguanosine triphosphate (4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180691</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754722</externalid>
        <name>acetaminophen O-beta-D-glucosiduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9756761</externalid>
        <name>2-hydroxyatorvastatin lactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180932</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754892</externalid>
        <name>ribavirin 5'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755268</externalid>
        <name>6-Thioguanosine monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180686</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9748787</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9749641</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9753281</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2161522</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9754706</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9755088</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9757110</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9793528</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9748784</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9748787</externalid>
    <name>Azathioprine ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9748787</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325571</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325583</externalid>
        <name>GSTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18879</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315963</externalid>
        <name>GUK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46195</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315983</externalid>
        <name>IMPDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321899</externalid>
        <name>TPMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342460</externalid>
        <name>LOC515333</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316371</externalid>
        <name>XDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356218</externalid>
        <name>ABCC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318493</externalid>
        <name>SLC29A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325575</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318518</externalid>
        <name>SLC28A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325579</externalid>
        <name>GSTA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315970</externalid>
        <name>GMPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325597</externalid>
        <name>GSTM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316341</externalid>
        <name>HPRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318525</externalid>
        <name>SLC28A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N428</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346210</externalid>
        <name>NME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367515</externalid>
        <name>NUDT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318489</externalid>
        <name>SLC29A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346206</externalid>
        <name>NME1-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52175</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9756758</externalid>
        <name>GS-nitroimidazole</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180931</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755276</externalid>
        <name>6 thioguanosine triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180688</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755275</externalid>
        <name>6 thiodeoxyguanosine monophosphate (2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748950</externalid>
        <name>6-Thiourate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755272</externalid>
        <name>6-thioinosine-5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180684</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748971</externalid>
        <name>9-(5-phosphoribofuranosyl)-6-mercaptopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2332</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748948</externalid>
        <name>6-Thioguanosine monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748966</externalid>
        <name>methylthioinosine monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>3037883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157761</externalid>
        <name>6-methylthiopurine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9748964</externalid>
        <name>6-Thioxanthine 5'-monophosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>80612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755273</externalid>
        <name>6-thiodeoxyguanosine triphosphate (4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180691</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755270</externalid>
        <name>6 thiodeoxyguanosine diphosphate (3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180690</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114901</externalid>
        <name>molybdopterin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>44074</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755274</externalid>
        <name>6-Thioxanthine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180685</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755279</externalid>
        <name>6-Thioguanosine diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180687</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755268</externalid>
        <name>6-Thioguanosine monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180686</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736312</externalid>
        <name>5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58017</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9748787</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9749641</externalid>
    <name>Aspirin ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9749641</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387314</externalid>
        <name>CES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409868</externalid>
        <name>BCHE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32749</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356212</externalid>
        <name>ABCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322124</externalid>
        <name>GLYATL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317733</externalid>
        <name>CYP2C88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322128</externalid>
        <name>GLYATL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317729</externalid>
        <name>CYP2C85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322137</externalid>
        <name>ACSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328296</externalid>
        <name>ABCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322107</externalid>
        <name>ACSM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317725</externalid>
        <name>CYP2C87</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387320</externalid>
        <name>CES2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346742</externalid>
        <name>SLC22A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322141</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317739</externalid>
        <name>CYP2D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q01361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749996</externalid>
        <name>2,3-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749980</externalid>
        <name>1-salicylate O-glucuronide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9750003</externalid>
        <name>Gentisuric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88742</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749982</externalid>
        <name>salicylic acyl beta-D-glucuronide (1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>176960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314684</externalid>
        <name>acetylsalicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>13719</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2314680</externalid>
        <name>salicylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30762</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749989</externalid>
        <name>2,5-dihydroxybenzoyl-CoA</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90176</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>40939</externalid>
        <name>salicyluric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9008</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9749978</externalid>
        <name>2,5-dihydroxybenzoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58044</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9749641</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9753281</externalid>
    <name>Paracetamol ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9753281</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334185</externalid>
        <name>ABCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321870</externalid>
        <name>LOC100296421</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354401</externalid>
        <name>CNDP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356218</externalid>
        <name>ABCC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321874</externalid>
        <name>LOC100138908</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325783</externalid>
        <name>SULT1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321890</externalid>
        <name>UGT2B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321886</externalid>
        <name>LOC100296421</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325597</externalid>
        <name>GSTM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4L7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321987</externalid>
        <name>NAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378928</externalid>
        <name>ACY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321878</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325641</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334159</externalid>
        <name>GGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356212</externalid>
        <name>ABCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378911</externalid>
        <name>GGT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342460</externalid>
        <name>LOC515333</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317717</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328296</externalid>
        <name>ABCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321853</externalid>
        <name>SULT1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321882</externalid>
        <name>LOC100138004</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325647</externalid>
        <name>GSTT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334167</externalid>
        <name>GGT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325789</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325853</externalid>
        <name>LOC100300896</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754727</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753450</externalid>
        <name>N-Acetyl-p-benzoquinonimine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>173517</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753641</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)cysteine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133066</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753782</externalid>
        <name>Paracetamol-Cys-Gly conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943596</externalid>
        <name>L-cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166427</externalid>
        <name>paracetamol sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32635</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754715</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)cysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133067</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9753646</externalid>
        <name>S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133435</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754722</externalid>
        <name>acetaminophen O-beta-D-glucosiduronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132962</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166424</externalid>
        <name>acetaminophen glutathione conjugate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>166426</externalid>
        <name>acetaminophen O-beta-D-glucosiduronic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754724</externalid>
        <name>N-acetyl-L-cysteinate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78236</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9753281</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2161522</externalid>
    <name>Abacavir ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2161522</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316380</externalid>
        <name>NT5C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346712</externalid>
        <name>SLC22A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365666</externalid>
        <name>ADAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162237</externalid>
        <name>abacavir 5'-carboxylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64192</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161179</externalid>
        <name>cyclopropylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34660</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2161517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2161541</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2161522</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2161517</externalid>
    <name>Abacavir transmembrane transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2161517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346712</externalid>
        <name>SLC22A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2161517</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2161522</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2161541</externalid>
    <name>Abacavir metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2161541</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316380</externalid>
        <name>NT5C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314204</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365666</externalid>
        <name>ADAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2162237</externalid>
        <name>abacavir 5'-carboxylic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64192</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2161179</externalid>
        <name>cyclopropylamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34660</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2161541</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2161522</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9754706</externalid>
    <name>Atorvastatin ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9754706</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356212</externalid>
        <name>ABCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403451</externalid>
        <name>PON3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347488</externalid>
        <name>SLCO2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403439</externalid>
        <name>PON1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356366</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9756763</externalid>
        <name>4-hydroxyatorvastatin lactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180934</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9756761</externalid>
        <name>2-hydroxyatorvastatin lactone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180932</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9754706</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9755088</externalid>
    <name>Ribavirin ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9755088</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316380</externalid>
        <name>NT5C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318493</externalid>
        <name>SLC29A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368456</externalid>
        <name>ITPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318518</externalid>
        <name>SLC28A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316355</externalid>
        <name>ADA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318525</externalid>
        <name>SLC28A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N428</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346210</externalid>
        <name>NME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347058</externalid>
        <name>SLC29A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MX44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318532</externalid>
        <name>ADK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346206</externalid>
        <name>NME1-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52175</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9731651</externalid>
        <name>IMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58053</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9755047</externalid>
        <name>1,2,4-triazole-3-carboxamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180482</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754919</externalid>
        <name>ribavirin 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754994</externalid>
        <name>ribavirin carboxylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754982</externalid>
        <name>ribavirin 5'-diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114736</externalid>
        <name>phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9754892</externalid>
        <name>ribavirin 5'-triphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>189093</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737589</externalid>
        <name>alpha-D-ribose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57720</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9755088</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9757110</externalid>
    <name>Prednisone ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9757110</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327654</externalid>
        <name>LOC506594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321870</externalid>
        <name>LOC100296421</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355537</externalid>
        <name>SERPINA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328255</externalid>
        <name>HSD11B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8K3KFT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321544</externalid>
        <name>CYP3A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327674</externalid>
        <name>LOC132342089</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327650</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328261</externalid>
        <name>HSD11B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3U0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327670</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327662</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356366</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB23</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327638</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P52898</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10321874</externalid>
        <name>LOC100138908</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321890</externalid>
        <name>UGT2B10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321886</externalid>
        <name>LOC100296421</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327658</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321878</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321536</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327642</externalid>
        <name>LOC132342107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321882</externalid>
        <name>LOC100138004</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327646</externalid>
        <name>LOC527068</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321540</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327678</externalid>
        <name>AKR1C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327666</externalid>
        <name>20ALPHA-HSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>M0QW14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321548</externalid>
        <name>CYP3A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T047</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9757546</externalid>
        <name>20beta-dihydroprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>182970</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757550</externalid>
        <name>20beta-dihydroprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180696</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757557</externalid>
        <name>6beta-hydroxyprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180697</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757553</externalid>
        <name>20alpha-dihydroprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>182969</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757543</externalid>
        <name>6beta-hydroxyprednisone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>180930</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9757544</externalid>
        <name>20alpha-dihydroprednisolone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>166776</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9757110</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9793528</externalid>
    <name>Ciprofloxacin ADME</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9793528</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10348880</externalid>
        <name>ABCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B2D1N9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10328289</externalid>
        <name>SLCO1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDW7</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
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    </genes>
    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793627</externalid>
        <name>ciprofloxacin zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>192484</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793567</externalid>
        <name>ciprofloxacin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>192486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-9793528</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9748784</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8953854</externalid>
    <name>Metabolism of RNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8953854</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10314728</externalid>
        <name>CPSF3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79101</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415489</externalid>
        <name>WBP11</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNM6</externalid>
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      </gene>
      <gene>
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        <name>CWC27</name>
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            <xref>
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              <externalid>F1MBE0</externalid>
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      <gene>
        <externalid>10415681</externalid>
        <name>WDR70</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415693</externalid>
        <name>DHX35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDN4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415703</externalid>
        <name>DHX8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEM4</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10342742</externalid>
        <name>CNOT9</name>
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          <protein>
            <xref>
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              <externalid>A7MB47</externalid>
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      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A7YY75</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415383</externalid>
        <name>PPP1R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317297</externalid>
        <name>GLE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBK7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317051</externalid>
        <name>PRPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348896</externalid>
        <name>UPF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK9</externalid>
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      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>HSPB1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>CNOT1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>POLR2C</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>TRA2B</name>
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          </protein>
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      <gene>
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        <name>SMG7</name>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PPP1CB</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>APOBEC1</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>EDC4</name>
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          </protein>
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      <gene>
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        <name>SRSF11</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MPHOSPH6</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>PCF11</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>DDX23</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>SRSF12</name>
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          </protein>
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      <gene>
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        <name>CPSF7</name>
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            <xref>
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          </protein>
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      <gene>
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        <name>PHF5A</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>PRR3</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>RPS3A</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>FTSJ3</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>NOL6</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>RBM22</name>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>7-methylguanosine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>20794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32955</externalid>
        <name>7-methylguanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32931</externalid>
        <name>3-methylguanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1604</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6784455</externalid>
        <name>L-threonylcarbamoyladenylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73687</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35431</externalid>
        <name>7-methylguanosine 5'-phosphate(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942297</externalid>
        <name>queuosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31763</externalid>
        <name>queuine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72086</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72203</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75067</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75072</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450531</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-429914</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-927802</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72312</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72306</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-194441</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9930044</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8953854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72086</externalid>
    <name>mRNA Capping</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72086</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317922</externalid>
        <name>RNGTT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317939</externalid>
        <name>RNMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317943</externalid>
        <name>SUPT5H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72086</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72203</externalid>
    <name>Processing of Capped Intron-Containing Pre-mRNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72203</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314728</externalid>
        <name>CPSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79101</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415681</externalid>
        <name>WDR70</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415489</externalid>
        <name>WBP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415527</externalid>
        <name>CWC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415693</externalid>
        <name>DHX35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415551</externalid>
        <name>RBMX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415703</externalid>
        <name>DHX8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314660</externalid>
        <name>THOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314596</externalid>
        <name>DHX38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317039</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415383</externalid>
        <name>PPP1R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE1</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369823</externalid>
        <name>RBM39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415435</externalid>
        <name>DHX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314572</externalid>
        <name>TRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420637</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370132</externalid>
        <name>PPP1CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314496</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318096</externalid>
        <name>SLBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314458</externalid>
        <name>SRSF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314780</externalid>
        <name>PCF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317055</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MII4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342657</externalid>
        <name>LSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390166</externalid>
        <name>SNU13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316989</externalid>
        <name>SF3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415744</externalid>
        <name>IK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314754</externalid>
        <name>PAPOLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25500</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415665</externalid>
        <name>PPWD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317047</externalid>
        <name>DDX23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415575</externalid>
        <name>PNN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415717</externalid>
        <name>STEEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T197</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314454</externalid>
        <name>RBMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3JUI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314474</externalid>
        <name>SRSF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370326</externalid>
        <name>DDX41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314764</externalid>
        <name>CPSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415423</externalid>
        <name>PHF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420627</externalid>
        <name>PRR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314546</externalid>
        <name>HNRNPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415345</externalid>
        <name>RBM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317243</externalid>
        <name>NXT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316933</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415779</externalid>
        <name>LENG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314462</externalid>
        <name>SRSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314692</externalid>
        <name>POLDIP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YW33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NXF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBM22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72172</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72187</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72202</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72203</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72172</externalid>
    <name>mRNA Splicing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72172</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10415527</externalid>
        <name>CWC27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415489</externalid>
        <name>WBP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415681</externalid>
        <name>WDR70</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415693</externalid>
        <name>DHX35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415551</externalid>
        <name>RBMX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415703</externalid>
        <name>DHX8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317039</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314596</externalid>
        <name>DHX38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314538</externalid>
        <name>HNRNPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397737</externalid>
        <name>SRRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317051</externalid>
        <name>PRPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314500</externalid>
        <name>SRSF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314478</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415775</externalid>
        <name>C11H9ORF78</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415515</externalid>
        <name>CWC22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314466</externalid>
        <name>SRSF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415523</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415357</externalid>
        <name>SRRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415563</externalid>
        <name>MFAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415353</externalid>
        <name>HTATSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314470</externalid>
        <name>SFRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317059</externalid>
        <name>SNRNP200</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415435</externalid>
        <name>DHX15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369823</externalid>
        <name>RBM39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314572</externalid>
        <name>TRA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314496</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314458</externalid>
        <name>SRSF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317055</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MII4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342657</externalid>
        <name>LSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390166</externalid>
        <name>SNU13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3B8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316989</externalid>
        <name>SF3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415744</externalid>
        <name>IK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUY8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415665</externalid>
        <name>PPWD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415575</externalid>
        <name>PNN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317047</externalid>
        <name>DDX23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415717</externalid>
        <name>STEEP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T197</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314454</externalid>
        <name>RBMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3JUI8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314474</externalid>
        <name>SRSF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWK4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370326</externalid>
        <name>DDX41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN07</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415423</externalid>
        <name>PHF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV59</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314546</externalid>
        <name>HNRNPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415345</externalid>
        <name>RBM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415779</externalid>
        <name>LENG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>SRSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RBM22</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F2Z4G3</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72163</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72165</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72172</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72203</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72163</externalid>
    <name>mRNA Splicing - Major Pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72163</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>CWC27</name>
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          <protein>
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              <externalid>F1MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WBP11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNM6</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>WDR70</name>
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          <protein>
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              <externalid>A0A3Q1MCF1</externalid>
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          </protein>
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      <gene>
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        <name>DHX35</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BDN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415551</externalid>
        <name>RBMX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3B6</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>RBM17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB77</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>DHX8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DHX38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC112442676</name>
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          <protein>
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              <externalid>A0A3Q1LW50</externalid>
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          </protein>
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      <gene>
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        <name>HNRNPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>CDC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJC1</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
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              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
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          </protein>
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      <gene>
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        <name>HNRNPD</name>
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          <protein>
            <xref>
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              <externalid>A6H6Y0</externalid>
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          </protein>
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      <gene>
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        <name>SRRT</name>
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          <protein>
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              <externalid>A4IFB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317051</externalid>
        <name>PRPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314500</externalid>
        <name>SRSF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314478</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415339</externalid>
        <name>RBM25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388877</externalid>
        <name>XAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314568</externalid>
        <name>YBX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314618</externalid>
        <name>MAGOH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415775</externalid>
        <name>C11H9ORF78</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415748</externalid>
        <name>SMU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415515</externalid>
        <name>CWC22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314466</externalid>
        <name>SRSF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415473</externalid>
        <name>CTNNBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415754</externalid>
        <name>UBL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415523</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415357</externalid>
        <name>SRRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373693</externalid>
        <name>DDX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M155</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415766</externalid>
        <name>ZMAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P584</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415563</externalid>
        <name>MFAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415603</externalid>
        <name>PRPF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415353</externalid>
        <name>HTATSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415733</externalid>
        <name>FAM32A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314470</externalid>
        <name>SFRS9</name>
        <entity>
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      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72163</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72172</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72165</externalid>
    <name>mRNA Splicing - Minor Pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72165</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314492</externalid>
        <name>SRSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317031</externalid>
        <name>ZRSR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317039</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316956</externalid>
        <name>SNRPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316943</externalid>
        <name>SNRPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317051</externalid>
        <name>PRPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317019</externalid>
        <name>ZCRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314568</externalid>
        <name>YBX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316997</externalid>
        <name>SF3B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316947</externalid>
        <name>SNRPG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317043</externalid>
        <name>SNRNP40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317001</externalid>
        <name>SF3B4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317059</externalid>
        <name>SNRNP200</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316961</externalid>
        <name>SNRPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K134</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316951</externalid>
        <name>SNRPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316993</externalid>
        <name>SF3B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317023</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LY80</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317055</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T106</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10316989</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10317047</externalid>
        <name>DDX23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB2</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PDCD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>ZMAT5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72172</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72187</externalid>
    <name>mRNA 3'-end processing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72187</url>
    <taxonomy>
      <taxnode>
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    </taxonomy>
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        <name>CPSF3</name>
        <entity>
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              <externalid>P79101</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CSTF2T</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415443</externalid>
        <name>RBM17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC112442676</name>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>PPP1R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE1</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HNRNPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SRRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314744</externalid>
        <name>WDR33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314500</externalid>
        <name>SRSF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415339</externalid>
        <name>RBM25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314478</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10420637</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370132</externalid>
        <name>PPP1CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314496</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5R8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316951</externalid>
        <name>SNRPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351672</externalid>
        <name>RBBP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314724</externalid>
        <name>CPSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q10568</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314458</externalid>
        <name>SRSF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314520</externalid>
        <name>HNRNPU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314506</externalid>
        <name>SRSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314558</externalid>
        <name>HNRNPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415447</externalid>
        <name>SMNDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314780</externalid>
        <name>PCF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314510</externalid>
        <name>SRSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316989</externalid>
        <name>SF3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314754</externalid>
        <name>PAPOLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25500</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415413</externalid>
        <name>SF3A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415325</externalid>
        <name>SF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314454</externalid>
        <name>RBMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3JUI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314474</externalid>
        <name>SRSF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314764</externalid>
        <name>CPSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415423</externalid>
        <name>PHF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420627</externalid>
        <name>PRR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415379</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314546</externalid>
        <name>HNRNPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314790</externalid>
        <name>CSTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316933</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314462</externalid>
        <name>SRSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9770562</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72187</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72203</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9770562</externalid>
    <name>mRNA Polyadenylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9770562</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>CPSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79101</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314798</externalid>
        <name>CSTF2T</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415443</externalid>
        <name>RBM17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314526</externalid>
        <name>HNRNPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P09867</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415383</externalid>
        <name>PPP1R8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314538</externalid>
        <name>HNRNPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397737</externalid>
        <name>SRRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314744</externalid>
        <name>WDR33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314500</externalid>
        <name>SRSF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415339</externalid>
        <name>RBM25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314478</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419753</externalid>
        <name>PAPOLG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314568</externalid>
        <name>YBX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314466</externalid>
        <name>SRSF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415357</externalid>
        <name>SRRM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373693</externalid>
        <name>DDX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M155</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326276</externalid>
        <name>PPP1CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415353</externalid>
        <name>HTATSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314760</externalid>
        <name>NUDT21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314470</externalid>
        <name>SFRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314576</externalid>
        <name>RBM10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NN09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314604</externalid>
        <name>U2AF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316961</externalid>
        <name>SNRPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K134</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314530</externalid>
        <name>HNRNPA2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370347</externalid>
        <name>DHX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28141</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415405</externalid>
        <name>SNRPB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316993</externalid>
        <name>SF3B2</name>
        <entity>
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        </entity>
      </gene>
      <gene>
        <externalid>10314454</externalid>
        <name>RBMX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D3JUI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314474</externalid>
        <name>SRSF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314764</externalid>
        <name>CPSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415423</externalid>
        <name>PHF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420627</externalid>
        <name>PRR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415379</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314546</externalid>
        <name>HNRNPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314790</externalid>
        <name>CSTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316933</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314462</externalid>
        <name>SRSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9770562</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72187</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72202</externalid>
    <name>Transport of Mature Transcript to Cytoplasm</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72202</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>CPSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79101</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314492</externalid>
        <name>SRSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314660</externalid>
        <name>THOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314596</externalid>
        <name>DHX38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314668</externalid>
        <name>THOC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GLE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WDR33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAGOH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>U2AF1L4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T127</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THOC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314642</externalid>
        <name>SRRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314466</externalid>
        <name>SRSF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314600</externalid>
        <name>CDC40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZC3H11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SFRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314604</externalid>
        <name>U2AF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314682</externalid>
        <name>DDX39B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T147</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317127</externalid>
        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314608</externalid>
        <name>CASC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318096</externalid>
        <name>SLBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314458</externalid>
        <name>SRSF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314724</externalid>
        <name>CPSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q10568</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317121</externalid>
        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314632</externalid>
        <name>ALYREF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314506</externalid>
        <name>SRSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317131</externalid>
        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314510</externalid>
        <name>SRSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314674</externalid>
        <name>CIP29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314652</externalid>
        <name>THOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N153</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314678</externalid>
        <name>DDX39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E970</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314708</externalid>
        <name>U2AF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314636</externalid>
        <name>RNPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314736</externalid>
        <name>CPSF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314740</externalid>
        <name>SYMPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314590</externalid>
        <name>SLU7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314656</externalid>
        <name>THOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317243</externalid>
        <name>NXT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CPSF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>EIF4A3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>FYTTD1</name>
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          </protein>
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      <gene>
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        <name>MAGOHB</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SRSF2</name>
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          </protein>
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      <gene>
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        <name>POLDIP3</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>NXF1</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-159234</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72202</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72203</externalid>
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          <superset />
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    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-159236</externalid>
    <name>Transport of Mature mRNA derived from an Intron-Containing Transcript</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159236</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A7YY75</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>THOC5</name>
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          </protein>
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      <gene>
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        <name>DHX38</name>
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              <externalid>Q17R09</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1BD42</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1MZR0</externalid>
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          </protein>
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      <gene>
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        <name>RANBP2</name>
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              <externalid>A0A3Q1LLS4</externalid>
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          </protein>
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      <gene>
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        <name>POM121C</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>GLE1</name>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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      <gene>
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        <name>U2AF1L4</name>
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          </protein>
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      <gene>
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        <name>THOC1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>NUP188</name>
        <entity>
          <protein>
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              <externalid>F1N6B6</externalid>
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          </protein>
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      <gene>
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        <name>SRRM1</name>
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          <protein>
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              <externalid>A0A3Q1MP80</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SRSF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NUPL2</name>
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              <externalid>Q2YDG6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CDC40</name>
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          <protein>
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              <externalid>F1MBS9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ZC3H11A</name>
        <entity>
          <protein>
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              <externalid>A5PKI2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SFRS9</name>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>U2AF2</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DDX39B</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AAAS</name>
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              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CASC3</name>
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          <protein>
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              <externalid>A5D7H5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SRSF11</name>
        <entity>
          <protein>
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              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP58</name>
        <entity>
          <protein>
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              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ALYREF</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3T0I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SRSF3</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP210</name>
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          <protein>
            <xref>
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              <externalid>F1MPW7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP205</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SRSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CIP29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP133</name>
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          <protein>
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              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N153</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DDX39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E970</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314708</externalid>
        <name>U2AF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4K8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314636</externalid>
        <name>RNPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP88</name>
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        </linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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  </biosystem>
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        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345141</externalid>
        <name>TNPO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345145</externalid>
        <name>ZFP36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342691</externalid>
        <name>DCP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342850</externalid>
        <name>EXOSC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-450408</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450385</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450513</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450604</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450520</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-450531</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-450408</externalid>
    <name>AUF1 (hnRNP D0) binds and destabilizes mRNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-450408</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314538</externalid>
        <name>HNRNPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345254</externalid>
        <name>HSPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T149</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345258</externalid>
        <name>HSPA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-450408</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450531</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-450385</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10345185</externalid>
        <name>XRN1</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345163</externalid>
        <name>ZFP36L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342828</externalid>
        <name>EXOSC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342846</externalid>
        <name>EXOSC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342812</externalid>
        <name>EXOSC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4R4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342842</externalid>
        <name>EXOSC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10342820</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEW6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DCP1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>EXOSC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DCP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342832</externalid>
        <name>EXOSC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB54</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EXOSC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342838</externalid>
        <name>DIS3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R4</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-450385</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450531</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-450513</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>XRN1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BMZ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316907</externalid>
        <name>YWHAB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342828</externalid>
        <name>EXOSC5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAG2</externalid>
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      </gene>
      <gene>
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        <name>EXOSC2</name>
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          <protein>
            <xref>
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              <externalid>Q2KID0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10342812</externalid>
        <name>EXOSC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4R4</externalid>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
        <externalid>10342820</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BEW6</externalid>
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      </gene>
      <gene>
        <externalid>10342691</externalid>
        <name>DCP1A</name>
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          <protein>
            <xref>
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              <externalid>F1N4I7</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRA3</externalid>
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      <gene>
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        <name>DCP2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYZ4</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342850</externalid>
        <name>EXOSC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345141</externalid>
        <name>TNPO1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EXOSC8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU3</externalid>
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      <gene>
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        <name>DIS3</name>
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              <externalid>F1N1R4</externalid>
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      </gene>
      <gene>
        <externalid>10345145</externalid>
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          <protein>
            <xref>
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              <externalid>Q0VCR3</externalid>
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          </protein>
        </entity>
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          <externalid>456216</externalid>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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    </smallmolecules>
    <linkedsystems>
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      </linkedsystem>
      <linkedsystem>
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    <taxonomy>
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        <taxid>9913</taxid>
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              <externalid>E1BAG2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>EXOSC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID0</externalid>
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          </protein>
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      <gene>
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              <externalid>A8E4R4</externalid>
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              <externalid>Q3T0E1</externalid>
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        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BEW6</externalid>
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      <gene>
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              <externalid>Q7YRA3</externalid>
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      <gene>
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        <name>PARN</name>
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              <externalid>A0A3Q1M3Q2</externalid>
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      <gene>
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      <gene>
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              <externalid>G3MYZ4</externalid>
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      </gene>
      <gene>
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              <externalid>F1MB54</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
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          </protein>
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      <gene>
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        <name>YWHAZ</name>
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            <xref>
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              <externalid>P63103</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q2KHU3</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1R4</externalid>
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          </protein>
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      </gene>
    </genes>
    <linkedsystems>
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        <externalid>R-HSA-450604</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450531</externalid>
        <linkedsystemtype>
          <superset />
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    <name>HuR (ELAVL1) binds and stabilizes mRNA</name>
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    <taxonomy>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q3ZCE2</externalid>
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        <name>XPO1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BE98</externalid>
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      <gene>
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        <name>ANP32A</name>
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              <externalid>P51122</externalid>
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        </entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBM0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10319649</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NUP214</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345114</externalid>
        <name>SET</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-450520</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450531</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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    <externalid>R-BTA-429914</externalid>
    <name>Deadenylation-dependent mRNA decay</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-429914</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342828</externalid>
        <name>EXOSC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342728</externalid>
        <name>CNOT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342812</externalid>
        <name>EXOSC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342742</externalid>
        <name>CNOT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342842</externalid>
        <name>EXOSC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0E1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342768</externalid>
        <name>CNOT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342860</externalid>
        <name>SKIC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B885</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342677</externalid>
        <name>PATL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342779</externalid>
        <name>DCPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E535</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342799</externalid>
        <name>PAN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BML0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342868</externalid>
        <name>HBS1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M492</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342724</externalid>
        <name>CNOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319955</externalid>
        <name>SKIC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342846</externalid>
        <name>EXOSC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342732</externalid>
        <name>CNOT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N553</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342649</externalid>
        <name>LSM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342754</externalid>
        <name>CNOT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342764</externalid>
        <name>CNOT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342707</externalid>
        <name>DDX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342820</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342695</externalid>
        <name>DCP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342832</externalid>
        <name>EXOSC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342687</externalid>
        <name>EDC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342824</externalid>
        <name>EXOSC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342673</externalid>
        <name>LSM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342838</externalid>
        <name>DIS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342803</externalid>
        <name>PAN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342703</externalid>
        <name>EDC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342856</externalid>
        <name>SKIC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342657</externalid>
        <name>LSM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342816</externalid>
        <name>EXOSC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342736</externalid>
        <name>CNOT10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342746</externalid>
        <name>CNOT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342788</externalid>
        <name>PARN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Q2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342699</externalid>
        <name>DCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342653</externalid>
        <name>LSM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342665</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342758</externalid>
        <name>CNOT6L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315085</externalid>
        <name>EIF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314612</externalid>
        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342669</externalid>
        <name>LSM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342661</externalid>
        <name>LSM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387448</externalid>
        <name>NT5C3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342716</externalid>
        <name>PAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342691</externalid>
        <name>DCP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342750</externalid>
        <name>TNKS1BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4H7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342850</externalid>
        <name>EXOSC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>429986</externalid>
        <name>7-methylguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>20794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35431</externalid>
        <name>7-methylguanosine 5'-phosphate(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-429947</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-429958</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-430039</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-429914</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-429947</externalid>
    <name>Deadenylation of mRNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-429947</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10342799</externalid>
        <name>PAN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BML0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342724</externalid>
        <name>CNOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342728</externalid>
        <name>CNOT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342732</externalid>
        <name>CNOT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N553</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342754</externalid>
        <name>CNOT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314612</externalid>
        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342742</externalid>
        <name>CNOT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB47</externalid>
            </xref>
          </protein>
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          </protein>
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      <gene>
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              <externalid>A4IFB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CNOT11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BHL0</externalid>
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          </protein>
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      <gene>
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        <name>PARN</name>
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          <protein>
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          <protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>PAN3</name>
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      <gene>
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      <smallmolecule>
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    </smallmolecules>
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    </linkedsystems>
  </biosystem>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315371</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315361</externalid>
        <name>RPL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315387</externalid>
        <name>RPL26L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315147</externalid>
        <name>RPLP0</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315407</externalid>
        <name>LOC101906221</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315277</externalid>
        <name>RPL28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348940</externalid>
        <name>SMG6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315179</externalid>
        <name>RPL14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315171</externalid>
        <name>RPL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315155</externalid>
        <name>RPLP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P42899</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315427</externalid>
        <name>RPL39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T051</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315167</externalid>
        <name>RPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61284</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315323</externalid>
        <name>RPL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314612</externalid>
        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348904</externalid>
        <name>GSPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q087</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315217</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342691</externalid>
        <name>DCP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314622</externalid>
        <name>MAGOHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315229</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315331</externalid>
        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975957</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975956</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-927802</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975957</externalid>
    <name>Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975957</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348932</externalid>
        <name>SMG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348896</externalid>
        <name>UPF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314618</externalid>
        <name>MAGOH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348926</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315191</externalid>
        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315411</externalid>
        <name>RPL36A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315281</externalid>
        <name>RPL29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348956</externalid>
        <name>SMG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
        <externalid>10315323</externalid>
        <name>RPL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314612</externalid>
        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348904</externalid>
        <name>GSPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q087</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315217</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342691</externalid>
        <name>DCP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314622</externalid>
        <name>MAGOHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315229</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315331</externalid>
        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-975957</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-927802</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975956</externalid>
    <name>Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975956</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348896</externalid>
        <name>UPF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315191</externalid>
        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315411</externalid>
        <name>RPL36A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315281</externalid>
        <name>RPL29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315265</externalid>
        <name>RPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q862I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315299</externalid>
        <name>RPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315383</externalid>
        <name>RPL26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315319</externalid>
        <name>RPL38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315159</externalid>
        <name>RPL10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315225</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315209</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315397</externalid>
        <name>RPL3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315335</externalid>
        <name>RPL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315315</externalid>
        <name>RPL37A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MIC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315403</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315243</externalid>
        <name>RPL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315307</externalid>
        <name>RPL36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T171</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315187</externalid>
        <name>LOC101903301</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N288</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348900</externalid>
        <name>ETF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315175</externalid>
        <name>RPL13A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>RIOK1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>NOL11</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MTREX</name>
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          </protein>
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      <gene>
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        <name>NOB1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CSNK1D</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>IMP4</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>FTSJ3</name>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>NOP56</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
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          </protein>
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      <gene>
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        <name>BOP1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MRX4</externalid>
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          </protein>
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      <gene>
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        <name>DDX21</name>
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          <protein>
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              <externalid>F6QHI8</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
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      <gene>
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        <name>EXOSC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UTP4</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC40</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
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          </protein>
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      <gene>
        <externalid>10314855</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS29</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
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          </protein>
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      <gene>
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        <name>RPL37</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>EMG1</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BK83</externalid>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>TSR1</name>
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      <gene>
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        <name>RPS10</name>
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              <externalid>Q3T0F4</externalid>
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          </protein>
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    </genes>
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      <linkedsystem>
        <externalid>R-HSA-6791226</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8868773</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>tRNA processing</name>
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    <url>http://www.reactome.org/content/detail/R-BTA-72306</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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        <name>QNG1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MEP1</externalid>
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      <gene>
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        <name>YRDC</name>
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              <externalid>Q0VC80</externalid>
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          </protein>
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    </genes>
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        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>6784455</externalid>
        <name>L-threonylcarbamoyladenylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73687</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942297</externalid>
        <name>queuosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31763</externalid>
        <name>queuine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17433</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6782315</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6787450</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72306</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6782315</externalid>
    <name>tRNA modification in the nucleus and cytosol</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6782315</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <externalid>10420195</externalid>
        <name>QNG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEP1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9658960</externalid>
        <name>D-ribofuranose 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78346</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9942297</externalid>
        <name>queuosine 5'-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>194371</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31763</externalid>
        <name>queuine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17433</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6782315</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72306</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6787450</externalid>
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    <biosystemtype>
      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6787450</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>YRDC</name>
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              <externalid>Q0VC80</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>6784455</externalid>
        <name>L-threonylcarbamoyladenylate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73687</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943634</externalid>
        <name>L-threonine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57926</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6787450</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72306</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-194441</externalid>
    <name>Metabolism of non-coding RNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-194441</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10327518</externalid>
        <name>SNUPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBK8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327458</externalid>
        <name>DDX20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316956</externalid>
        <name>SNRPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316943</externalid>
        <name>SNRPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327549</externalid>
        <name>CLNS1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316947</externalid>
        <name>SNRPG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327454</externalid>
        <name>GEMIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327466</externalid>
        <name>GEMIN5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316961</externalid>
        <name>SNRPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K134</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317127</externalid>
        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316951</externalid>
        <name>SNRPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327470</externalid>
        <name>GEMIN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327478</externalid>
        <name>SMN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327482</externalid>
        <name>GEMIN8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZ79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317121</externalid>
        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327545</externalid>
        <name>WDR77</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317131</externalid>
        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327462</externalid>
        <name>GEMIN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327474</externalid>
        <name>GEMIN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317159</externalid>
        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327541</externalid>
        <name>PRMT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316933</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317163</externalid>
        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317117</externalid>
        <name>NUP54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24K19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317189</externalid>
        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316937</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N150</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317147</externalid>
        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327530</externalid>
        <name>TGS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1K9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32955</externalid>
        <name>7-methylguanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2274</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32931</externalid>
        <name>3-methylguanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1604</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-191859</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-194441</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-191859</externalid>
    <name>snRNP Assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-191859</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327518</externalid>
        <name>SNUPN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327458</externalid>
        <name>DDX20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316956</externalid>
        <name>SNRPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316943</externalid>
        <name>SNRPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316925</externalid>
        <name>SNRPD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327549</externalid>
        <name>CLNS1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316947</externalid>
        <name>SNRPG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL0</externalid>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311557</externalid>
        <name>MCM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312260</externalid>
        <name>POLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325890</externalid>
        <name>GINS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-69002</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69239</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9913635</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-69306</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-69002</externalid>
    <name>DNA Replication Pre-Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-69002</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311504</externalid>
        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311889</externalid>
        <name>RPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311935</externalid>
        <name>MCM6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311939</externalid>
        <name>MCM7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311654</externalid>
        <name>ANAPC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311885</externalid>
        <name>RPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311923</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8P0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311551</externalid>
        <name>CDC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311901</externalid>
        <name>CDC45</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311858</externalid>
        <name>POLE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311850</externalid>
        <name>PRIM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311542</externalid>
        <name>ORC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311617</externalid>
        <name>FZR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
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              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10414500</externalid>
        <name>KPNA6</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G5E536</externalid>
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          </protein>
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      <gene>
        <externalid>56227</externalid>
        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>E1BFZ9</externalid>
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          </protein>
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      <gene>
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        <name>POLE3</name>
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      <gene>
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      <gene>
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        <name>PSMD12</name>
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      <gene>
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        <name>HIST1H2BI</name>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
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    <name>Assembly of the pre-replicative complex</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68867</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>G3N011</externalid>
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      <gene>
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        <name>LOC528006</name>
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      <gene>
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        <name>ORC3</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>ORC6</name>
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        <name>FZR1</name>
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          </protein>
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      <gene>
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        <name>H2AJ</name>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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        <name>UBB</name>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-68616</url>
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        <name>KPNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311520</externalid>
        <name>ORC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311500</externalid>
        <name>ORC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ORC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>H2AJ</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312736</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>KPNA6</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>56227</externalid>
        <entity>
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            <xref>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
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        <entity>
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      <gene>
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        <name>HIST1H2BI</name>
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          <protein>
            <xref>
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      <gene>
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        <name>H2AC6</name>
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            <xref>
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        <entity>
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          </protein>
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      <gene>
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        <name>H2AZ2</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-68616</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68867</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>CDC6 association with the ORC:origin complex</name>
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    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-68689</url>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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        <name>ORC1</name>
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          </protein>
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      <gene>
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        <name>CDC6</name>
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              <externalid>E1BAQ1</externalid>
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      <gene>
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              <externalid>Q2HJF3</externalid>
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      <gene>
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        <name>ORC2</name>
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              <externalid>A0A3Q1LR25</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-68867</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Strand-asynchronous mitochondrial DNA replication</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9913635</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>POLRMT</name>
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          <protein>
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              <externalid>E1BCZ0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>POLG2</name>
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              <externalid>Q0VC30</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C26H10ORF2</name>
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          <protein>
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              <externalid>A5D7A7</externalid>
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          </protein>
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      <gene>
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              <externalid>F1N1S0</externalid>
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      <gene>
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              <externalid>E1BDI3</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
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        <name>UTP(4-)</name>
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          <externalid>46398</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>CTP(4-)</name>
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          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737463</externalid>
        <name>dGTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61429</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737453</externalid>
        <name>dATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61404</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737457</externalid>
        <name>dCTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>61481</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737461</externalid>
        <name>dTTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37568</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9913635</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-69306</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112316</externalid>
    <name>Neuronal System</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112316</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>KCNH5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MP51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390686</externalid>
        <name>NLGN1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F6Q4B1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GRIK5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD2</externalid>
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          </protein>
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      <gene>
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        <name>DLG4</name>
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          <protein>
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              <externalid>F1MM66</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390963</externalid>
        <name>LRRTM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
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              <externalid>Q5E9F0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10342318</externalid>
        <name>SLC32A1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N354</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355194</externalid>
        <entity>
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              <externalid>F1MX91</externalid>
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          </protein>
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      <gene>
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        <name>KCNK10</name>
        <entity>
          <protein>
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              <externalid>F1MLI5</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <externalid>E1BLH0</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>P48018</externalid>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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        <name>N-(octadecanoyl)ethanolamine</name>
        <xref>
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      <smallmolecule>
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        <name>homovanillic acid</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5317374</externalid>
        <name>(3,4-dihydroxyphenyl)acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17612</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803735</externalid>
        <name>N-(tetradecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
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      <smallmolecule>
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        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5317375</externalid>
        <name>3,4-dihydroxymandelaldehyde</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>27852</externalid>
        </xref>
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      <smallmolecule>
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        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
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      <smallmolecule>
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        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
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      <smallmolecule>
        <externalid>2327982</externalid>
        <name>(5-hydroxyindol-3-yl)acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27823</externalid>
        </xref>
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      <smallmolecule>
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        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803749</externalid>
        <name>N-(dodecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
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      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
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      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
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      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
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      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
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      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
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      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
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      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347702</externalid>
        <name>DNAJC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350762</externalid>
        <name>GABRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347669</externalid>
        <name>ALDH5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>6803734</externalid>
        <name>N-(octadecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85299</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37517</externalid>
        <name>homovanillic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>545959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317374</externalid>
        <name>(3,4-dihydroxyphenyl)acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803735</externalid>
        <name>N-(tetradecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317375</externalid>
        <name>3,4-dihydroxymandelaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327982</externalid>
        <name>(5-hydroxyindol-3-yl)acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803749</externalid>
        <name>N-(dodecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955018</externalid>
        <name>3-methoxytyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803757</externalid>
        <name>palmitoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-112308</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112311</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112313</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112315</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112308</externalid>
    <name>Presynaptic depolarization and calcium channel opening</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112308</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332866</externalid>
        <name>CACNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332890</externalid>
        <name>CACNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332874</externalid>
        <name>CACNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N167</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332862</externalid>
        <name>CACNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9MZL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332880</externalid>
        <name>CACNA2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332884</externalid>
        <name>CACNA2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332870</externalid>
        <name>CACNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-112308</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112310</externalid>
    <name>Neurotransmitter release cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112310</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332832</externalid>
        <name>SLC1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332903</externalid>
        <name>SLC17A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342318</externalid>
        <name>SLC32A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N354</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332851</externalid>
        <name>ARL6IP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348583</externalid>
        <name>ABAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333549</externalid>
        <name>SLC38A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329983</externalid>
        <name>SLC6A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332828</externalid>
        <name>SLC1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337959</externalid>
        <name>LIN7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394645</externalid>
        <name>NAAA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333810</externalid>
        <name>CHAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337938</externalid>
        <name>SYN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347688</externalid>
        <name>GAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337955</externalid>
        <name>LIN7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343679</externalid>
        <name>SLC6A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337951</externalid>
        <name>CASK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332844</externalid>
        <name>SLC1A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343675</externalid>
        <name>SLC6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313307</externalid>
        <name>GLS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334864</externalid>
        <name>SLC18A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337947</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342509</externalid>
        <name>SLC5A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333795</externalid>
        <name>SLC18A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332840</externalid>
        <name>SLC1A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347702</externalid>
        <name>DNAJC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332836</externalid>
        <name>SLC1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347678</externalid>
        <name>GAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347669</externalid>
        <name>ALDH5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337963</externalid>
        <name>LIN7C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>6803734</externalid>
        <name>N-(octadecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85299</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9915537</externalid>
        <name>ethanolaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57603</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803749</externalid>
        <name>N-(dodecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85263</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803735</externalid>
        <name>N-(tetradecanoyl)ethanolamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444547</externalid>
        <name>anandamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317375</externalid>
        <name>3,4-dihydroxymandelaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803757</externalid>
        <name>palmitoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71464</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-181430</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181429</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-210500</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212676</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-264642</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-888590</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112310</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-181430</externalid>
    <name>Norepinephrine Neurotransmitter Release Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-181430</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334864</externalid>
        <name>SLC18A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317375</externalid>
        <name>3,4-dihydroxymandelaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27852</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-181430</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-181429</externalid>
    <name>Serotonin Neurotransmitter Release Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-181429</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334864</externalid>
        <name>SLC18A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337938</externalid>
        <name>SYN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-181429</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-210500</externalid>
    <name>Glutamate Neurotransmitter Release Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-210500</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332832</externalid>
        <name>SLC1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332903</externalid>
        <name>SLC17A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332844</externalid>
        <name>SLC1A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332851</externalid>
        <name>ARL6IP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313307</externalid>
        <name>GLS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333549</externalid>
        <name>SLC38A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332828</externalid>
        <name>SLC1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332840</externalid>
        <name>SLC1A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332836</externalid>
        <name>SLC1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-210500</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-212676</externalid>
    <name>Dopamine Neurotransmitter Release Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-212676</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337951</externalid>
        <name>CASK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334864</externalid>
        <name>SLC18A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337947</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337959</externalid>
        <name>LIN7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337938</externalid>
        <name>SYN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337955</externalid>
        <name>LIN7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337963</externalid>
        <name>LIN7C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-212676</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-264642</externalid>
    <name>Acetylcholine Neurotransmitter Release Cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-264642</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332940</externalid>
        <name>UNC13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342509</externalid>
        <name>SLC5A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333795</externalid>
        <name>SLC18A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333810</externalid>
        <name>CHAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-264642</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-888590</externalid>
    <name>GABA synthesis, release, reuptake and degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-888590</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332928</externalid>
        <name>CPLX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343679</externalid>
        <name>SLC6A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332936</externalid>
        <name>RIMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342318</externalid>
        <name>SLC32A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N354</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343675</externalid>
        <name>SLC6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348583</externalid>
        <name>ABAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329983</externalid>
        <name>SLC6A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332920</externalid>
        <name>SNAP25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347702</externalid>
        <name>DNAJC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332899</externalid>
        <name>STXBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347678</externalid>
        <name>GAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347669</externalid>
        <name>ALDH5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347688</externalid>
        <name>GAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332932</externalid>
        <name>STX1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32850</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341541</externalid>
        <name>HSPA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19120</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-888568</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-888593</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-916853</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-888590</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112310</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-888568</externalid>
    <name>GABA synthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-888568</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347678</externalid>
        <name>GAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347688</externalid>
        <name>GAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-888568</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-888590</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-888593</externalid>
    <name>Reuptake of GABA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-888593</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343679</externalid>
        <name>SLC6A13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343675</externalid>
        <name>SLC6A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JND1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329983</externalid>
        <name>SLC6A11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329987</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJ84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>34421</externalid>
        <name>L-2,4-diaminobutyric acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48950</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30623</externalid>
        <name>glycine betaine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737737</externalid>
        <name>beta-alanine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57966</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-888593</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-888590</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-916853</externalid>
    <name>Degradation of GABA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-916853</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347669</externalid>
        <name>ALDH5A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348583</externalid>
        <name>ABAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1362317</externalid>
        <name>di-mu-sulfido-diiron(0)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654413</externalid>
        <name>4-oxobutanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57706</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-916853</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-888590</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112311</externalid>
    <name>Neurotransmitter clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112311</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337978</externalid>
        <name>SLC6A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335542</externalid>
        <name>SLC22A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335546</externalid>
        <name>SLC22A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314235</externalid>
        <name>ALDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20000</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337134</externalid>
        <name>SLC6A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325557</externalid>
        <name>COMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407063</externalid>
        <name>TOMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5317374</externalid>
        <name>(3,4-dihydroxyphenyl)acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37517</externalid>
        <name>homovanillic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>545959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955018</externalid>
        <name>3-methoxytyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327982</externalid>
        <name>(5-hydroxyindol-3-yl)acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-379401</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-380615</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112311</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379401</externalid>
    <name>Dopamine clearance from the synaptic cleft</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379401</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337134</externalid>
        <name>SLC6A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325557</externalid>
        <name>COMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407063</externalid>
        <name>TOMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5317374</externalid>
        <name>(3,4-dihydroxyphenyl)acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37517</externalid>
        <name>homovanillic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>545959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955018</externalid>
        <name>3-methoxytyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-379397</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379398</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-379401</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112311</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379397</externalid>
    <name>Enzymatic degradation of dopamine by COMT</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379397</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325557</externalid>
        <name>COMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407063</externalid>
        <name>TOMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37517</externalid>
        <name>homovanillic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>545959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8955018</externalid>
        <name>3-methoxytyramine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1582</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-379397</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379401</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379398</externalid>
    <name>Enzymatic degradation of Dopamine by monoamine oxidase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379398</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325557</externalid>
        <name>COMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>37517</externalid>
        <name>homovanillic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>545959</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317374</externalid>
        <name>(3,4-dihydroxyphenyl)acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17612</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9908225</externalid>
        <name>L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58199</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760899</externalid>
        <name>dopaminium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59905</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-379398</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379401</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-380615</externalid>
    <name>Serotonin clearance from the synaptic cleft</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-380615</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10337978</externalid>
        <name>SLC6A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XT49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314235</externalid>
        <name>ALDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20000</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327982</externalid>
        <name>(5-hydroxyindol-3-yl)acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-380612</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-380615</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112311</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-380612</externalid>
    <name>Metabolism of serotonin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-380612</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10321115</externalid>
        <name>MAOA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21398</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314235</externalid>
        <name>ALDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20000</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2327982</externalid>
        <name>(5-hydroxyindol-3-yl)acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37583</externalid>
        <name>(5-hydroxyindol-3-yl)acetaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50157</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-380612</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-380615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112313</externalid>
    <name>Neurotransmitter uptake and metabolism In glial cells</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112313</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332828</externalid>
        <name>SLC1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332832</externalid>
        <name>SLC1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333542</externalid>
        <name>SLC38A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313292</externalid>
        <name>GLUL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-210455</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112313</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-210455</externalid>
    <name>Astrocytic Glutamate-Glutamine Uptake And Metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-210455</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332828</externalid>
        <name>SLC1A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46411</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332832</externalid>
        <name>SLC1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333542</externalid>
        <name>SLC38A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313292</externalid>
        <name>GLUL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-210455</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112313</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112314</externalid>
    <name>Neurotransmitter receptors and postsynaptic signal transmission</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112314</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343044</externalid>
        <name>NEFL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02548</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345414</externalid>
        <name>GRIK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346936</externalid>
        <name>CHRNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02715</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346940</externalid>
        <name>CHRNG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13536</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350810</externalid>
        <name>GABRR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353142</externalid>
        <name>KCNJ16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343568</externalid>
        <name>RPS6KA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345404</externalid>
        <name>GRIK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345396</externalid>
        <name>GRIK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353130</externalid>
        <name>KCNJ10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353158</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350795</externalid>
        <name>GLRA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEK7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350726</externalid>
        <name>GABRA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCS2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340408</externalid>
        <name>GRIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340248</externalid>
        <name>EPB41L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N611</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RXS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350752</externalid>
        <name>GABRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340268</externalid>
        <name>CACNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350801</externalid>
        <name>GLRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GJS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347006</externalid>
        <name>CHRNA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350762</externalid>
        <name>GABRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347002</externalid>
        <name>CHRNA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353172</externalid>
        <name>KCNJ15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760913</externalid>
        <name>serotonin(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>350546</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-181431</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399721</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442755</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-451326</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-977443</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-112314</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112315</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-181431</externalid>
    <name>Acetylcholine binding and downstream events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-181431</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346936</externalid>
        <name>CHRNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02715</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346940</externalid>
        <name>CHRNG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13536</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346957</externalid>
        <name>CHRNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346963</externalid>
        <name>CHRNA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346932</externalid>
        <name>CHRND</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04759</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346981</externalid>
        <name>CHRNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347006</externalid>
        <name>CHRNA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347002</externalid>
        <name>CHRNA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-622323</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622327</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-181431</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-622323</externalid>
    <name>Presynaptic nicotinic acetylcholine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-622323</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346932</externalid>
        <name>CHRND</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04759</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346936</externalid>
        <name>CHRNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02715</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346940</externalid>
        <name>CHRNG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13536</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346957</externalid>
        <name>CHRNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346963</externalid>
        <name>CHRNA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346981</externalid>
        <name>CHRNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-629597</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-629587</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-622323</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181431</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-629597</externalid>
    <name>Highly calcium permeable nicotinic acetylcholine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-629597</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346957</externalid>
        <name>CHRNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346981</externalid>
        <name>CHRNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346963</externalid>
        <name>CHRNA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-629597</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622323</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-629587</externalid>
    <name>Highly sodium permeable postsynaptic acetylcholine nicotinic receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-629587</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346932</externalid>
        <name>CHRND</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04759</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346936</externalid>
        <name>CHRNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02715</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346940</externalid>
        <name>CHRNG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13536</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-629587</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622327</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622323</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-622327</externalid>
    <name>Postsynaptic nicotinic acetylcholine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-622327</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346936</externalid>
        <name>CHRNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02715</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346940</externalid>
        <name>CHRNG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13536</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346957</externalid>
        <name>CHRNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346963</externalid>
        <name>CHRNA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346932</externalid>
        <name>CHRND</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04759</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346981</externalid>
        <name>CHRNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347006</externalid>
        <name>CHRNA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347002</externalid>
        <name>CHRNA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-629594</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-629587</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-622327</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181431</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-629594</externalid>
    <name>Highly calcium permeable postsynaptic nicotinic acetylcholine receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-629594</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346912</externalid>
        <name>CHRNA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346957</externalid>
        <name>CHRNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02709</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346963</externalid>
        <name>CHRNA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346981</externalid>
        <name>CHRNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4T3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347006</externalid>
        <name>CHRNA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346975</externalid>
        <name>CHRNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346926</externalid>
        <name>CHRNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346922</externalid>
        <name>CHRNA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346916</externalid>
        <name>CHRNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347002</externalid>
        <name>CHRNA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346971</externalid>
        <name>CHRNA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-629594</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622327</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399721</externalid>
    <name>Glutamate binding, activation of AMPA receptors and synaptic plasticity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-399721</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340274</externalid>
        <name>CACNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327216</externalid>
        <name>MYO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A498UZ20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340408</externalid>
        <name>GRIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340248</externalid>
        <name>EPB41L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N611</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340412</externalid>
        <name>GRIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340268</externalid>
        <name>CACNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332890</externalid>
        <name>CACNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340480</externalid>
        <name>NSF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340264</externalid>
        <name>CACNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340485</externalid>
        <name>TSPAN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340252</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340404</externalid>
        <name>PICK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-399719</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399710</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-399721</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399719</externalid>
    <name>Trafficking of AMPA receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-399719</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340274</externalid>
        <name>CACNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327216</externalid>
        <name>MYO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A498UZ20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340408</externalid>
        <name>GRIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340248</externalid>
        <name>EPB41L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N611</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340412</externalid>
        <name>GRIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340268</externalid>
        <name>CACNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332890</externalid>
        <name>CACNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340480</externalid>
        <name>NSF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340264</externalid>
        <name>CACNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340485</externalid>
        <name>TSPAN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340252</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340404</externalid>
        <name>PICK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-416993</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-399719</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399721</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-416993</externalid>
    <name>Trafficking of GluR2-containing AMPA receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-416993</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10340485</externalid>
        <name>TSPAN7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6PZP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340408</externalid>
        <name>GRIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325979</externalid>
        <name>AP2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340412</externalid>
        <name>GRIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325987</externalid>
        <name>AP2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325971</externalid>
        <name>AP2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340480</externalid>
        <name>NSF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325983</externalid>
        <name>AP2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340404</externalid>
        <name>PICK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-416993</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399719</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-399710</externalid>
    <name>Activation of AMPA receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-399710</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-399710</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-399721</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-442755</externalid>
    <name>Activation of NMDA receptors and postsynaptic events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-442755</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343044</externalid>
        <name>NEFL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02548</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RXS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343568</externalid>
        <name>RPS6KA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343054</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339336</externalid>
        <name>ACTN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-438066</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-438064</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-442755</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-438066</externalid>
    <name>Unblocking of NMDA receptors, glutamate binding and activation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-438066</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10343044</externalid>
        <name>NEFL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02548</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339849</externalid>
        <name>GRIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343054</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339336</externalid>
        <name>ACTN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331961</externalid>
        <name>GRIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G0T3G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340312</externalid>
        <name>CAMK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340322</externalid>
        <name>CAMK2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340317</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M066</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943599</externalid>
        <name>glycine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57305</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9929612</externalid>
        <name>D-serine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35247</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-438066</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-438064</externalid>
    <name>Post NMDA receptor activation events</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-438064</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RXS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343568</externalid>
        <name>RPS6KA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-442742</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442720</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442729</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9619229</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-438064</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442755</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-442742</externalid>
    <name>CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-442742</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343568</externalid>
        <name>RPS6KA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-444257</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-442742</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-438064</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-444257</externalid>
    <name>RSK activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-444257</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343568</externalid>
        <name>RPS6KA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4X3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-444257</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-442742</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-442720</externalid>
    <name>CREB1 phosphorylation through the activation of Adenylate Cyclase</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-442720</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10319524</externalid>
        <name>PRKAR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319528</externalid>
        <name>PRKAR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319520</externalid>
        <name>PRKAR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00514</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319532</externalid>
        <name>PRKAR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-442720</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-438064</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-442729</externalid>
    <name>CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-442729</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319500</externalid>
        <name>CAMK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-442729</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-438064</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9619229</externalid>
    <name>Activation of RAC1 downstream of NMDARs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9619229</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343583</externalid>
        <name>CAMKK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343587</externalid>
        <name>CAMKK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410946</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RXS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9619229</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-438064</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-451326</externalid>
    <name>Activation of kainate receptors upon glutamate binding</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-451326</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345414</externalid>
        <name>GRIK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345382</externalid>
        <name>NCALD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61602</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345404</externalid>
        <name>GRIK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345378</externalid>
        <name>GRIK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345396</externalid>
        <name>GRIK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>98281</externalid>
        <name>PLCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319452</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345390</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-451306</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-500657</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-451326</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-451306</externalid>
    <name>Ionotropic activity of kainate receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-451306</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10345414</externalid>
        <name>GRIK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345396</externalid>
        <name>GRIK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345404</externalid>
        <name>GRIK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345382</externalid>
        <name>NCALD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61602</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345378</externalid>
        <name>GRIK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345390</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9Y0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-451307</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-451308</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-451306</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-451326</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-451307</externalid>
    <name>Activation of Na-permeable kainate receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-451307</url>
    <taxonomy>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350748</externalid>
        <name>GABRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08220</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350730</externalid>
        <name>GABRA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350738</externalid>
        <name>GABRA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350722</externalid>
        <name>GABRA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08219</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350752</externalid>
        <name>GABRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353134</externalid>
        <name>KCNJ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4TZY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350734</externalid>
        <name>GABRA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20237</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350742</externalid>
        <name>GABRA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE96</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353126</externalid>
        <name>KCNJ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19182</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350762</externalid>
        <name>GABRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353172</externalid>
        <name>KCNJ15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-977444</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-977443</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112314</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-977444</externalid>
    <name>GABA B receptor activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-977444</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353138</externalid>
        <name>KCNJ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353142</externalid>
        <name>KCNJ16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337578</externalid>
        <name>GABBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353162</externalid>
        <name>KCNJ5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353134</externalid>
        <name>KCNJ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4TZY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353130</externalid>
        <name>KCNJ10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353154</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353126</externalid>
        <name>KCNJ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19182</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353158</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353150</externalid>
        <name>KCNJ3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353172</externalid>
        <name>KCNJ15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-991365</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-977444</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-977443</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-991365</externalid>
    <name>Activation of GABAB receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-991365</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324404</externalid>
        <name>GNAI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353138</externalid>
        <name>KCNJ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319582</externalid>
        <name>ADCY8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BQ12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319567</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319563</externalid>
        <name>ADCY6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353142</externalid>
        <name>KCNJ16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319578</externalid>
        <name>ADCY5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319559</externalid>
        <name>ADCY4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337578</externalid>
        <name>GABBR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353162</externalid>
        <name>KCNJ5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353134</externalid>
        <name>KCNJ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4TZY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319551</externalid>
        <name>ADCY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324390</externalid>
        <name>GNAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N461</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353130</externalid>
        <name>KCNJ10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353154</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337582</externalid>
        <name>GABBR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324396</externalid>
        <name>GNAI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319555</externalid>
        <name>ADCY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>88553</externalid>
        <name>ADCY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P19754</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353126</externalid>
        <name>KCNJ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19182</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353158</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319571</externalid>
        <name>ADCY9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353150</externalid>
        <name>KCNJ3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324400</externalid>
        <name>GNAI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63097</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353172</externalid>
        <name>KCNJ15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-170670</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-997272</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-991365</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-977444</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-997272</externalid>
    <name>Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-997272</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10353138</externalid>
        <name>KCNJ4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1296071</url>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      </gene>
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        <name>KCNS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKI8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354837</externalid>
        <name>HCN3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353126</externalid>
        <name>KCNJ2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19182</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355040</externalid>
        <name>KCNS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPV7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354774</externalid>
        <name>KCNJ8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHY6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10334095</externalid>
        <name>KCNJ11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VDS4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10354843</externalid>
        <name>HCN4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIS4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10354896</externalid>
        <name>KCNA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7K3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10355173</externalid>
        <name>KCNK13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1Q6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354849</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354956</externalid>
        <name>KCNB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10354785</externalid>
        <name>KCNMB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354990</externalid>
        <name>KCNG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354812</externalid>
        <name>KCNN1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10337578</externalid>
        <name>GABBR1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355211</externalid>
        <name>KCNK9</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354984</externalid>
        <name>KCND3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10354922</externalid>
        <name>KCNH1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10353130</externalid>
        <name>KCNJ10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>KCNK4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BGH7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>KCNK17</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ABCC8</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKR6</externalid>
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          </protein>
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      <gene>
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        <name>HCN1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>KCNF1</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>KCNA10</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>KCNA7</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ABCC9</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>GNB5</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNA2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNC4</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNB3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354884</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MLD6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>KCNH6</name>
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              <externalid>E1BMA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNQ3</name>
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          </protein>
        </entity>
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      <gene>
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        <name>GNG4</name>
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              <externalid>A4IFL6</externalid>
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      <gene>
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              <externalid>F1MIZ5</externalid>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A5PJL2</externalid>
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      <gene>
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              <externalid>Q3SZ98</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316409</externalid>
        <name>gamma-aminobutyric acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59888</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1296052</externalid>
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      <linkedsystem>
        <externalid>R-BTA-1296061</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1296071</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112316</externalid>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1296052</externalid>
    <name>Ca2+ activated K+ channels</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1296052</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>KCNMB3</name>
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          <protein>
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              <externalid>Q1RMW7</externalid>
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      </gene>
      <gene>
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        <name>KCNMB1</name>
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              <externalid>Q28067</externalid>
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          </protein>
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      <gene>
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        <name>KCNN3</name>
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              <externalid>E1BHB0</externalid>
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          </protein>
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      <gene>
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        <name>KCNN2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N467</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354812</externalid>
        <name>KCNN1</name>
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          <protein>
            <xref>
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              <externalid>E1BGY2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10354797</externalid>
        <name>KCNMB4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCE5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNMA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28204</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1296052</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296071</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
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      <smallmolecule>
        <externalid>114810</externalid>
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    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296071</externalid>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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      <smallmolecule>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
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      <linkedsystem>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <linkedsystem>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N1T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNA3</name>
        <entity>
          <protein>
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              <externalid>E1B7K3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNH2</name>
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              <externalid>A0A3Q1LSF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>KCNAB1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q4PJK1</externalid>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>KCNA4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFZ3</externalid>
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          </protein>
        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BC13</externalid>
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          </protein>
        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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        <name>KCNG3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MC54</externalid>
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      <gene>
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        <name>KCNF1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV89</externalid>
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      <gene>
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        <name>KCNH7</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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              <externalid>F1MPV7</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1296072</externalid>
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      <linkedsystem>
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    </biosystemtype>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>E1BEH1</externalid>
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        <name>KCNK4</name>
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              <externalid>E1BGH7</externalid>
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      <gene>
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              <externalid>Q0P5A0</externalid>
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          </protein>
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      <gene>
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        <name>KCNK3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT89</externalid>
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          </protein>
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    </genes>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <subset />
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1299344</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <subset />
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296071</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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    </biosystemtype>
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      <taxnode>
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              <externalid>E1B9M4</externalid>
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          </protein>
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      <gene>
        <externalid>10355194</externalid>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KCNK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1299308</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296346</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-1299503</externalid>
    <name>TWIK related potassium channel (TREK)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1299503</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <externalid>10355075</externalid>
        <name>KCNK2</name>
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          <protein>
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              <externalid>A0A3Q1LQ50</externalid>
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        </entity>
      </gene>
      <gene>
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        <name>KCNK4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGH7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355071</externalid>
        <name>KCNK10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLI5</externalid>
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      </gene>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1299503</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296346</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1299316</externalid>
    <name>TWIK-releated acid-sensitive K+ channel (TASK)</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10355211</externalid>
        <name>KCNK9</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N1D1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355205</externalid>
        <name>KCNK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1299316</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1299361</externalid>
    <name>TWIK-related alkaline pH activated K+ channel (TALK)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
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      <gene>
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        <name>KCNK16</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355237</externalid>
        <name>KCNK17</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZT2</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-1299361</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296346</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1299344</externalid>
    <name>TWIK-related spinal cord K+ channel (TRESK)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1299344</url>
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      <taxnode>
        <taxid>9913</taxid>
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      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10355222</externalid>
        <name>KCNK18</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1299344</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1296346</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1299287</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N1Q6</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-6794362</externalid>
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      <organism_specific_biosystem />
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      <taxnode>
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        <name>NLGN1</name>
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          <protein>
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              <externalid>F6Q4B1</externalid>
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          </protein>
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      <gene>
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        <name>DLG4</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>HOMER2</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MSM8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJJ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390704</externalid>
        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10390766</externalid>
        <name>EPB41L2</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>CASK</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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        <name>LRRC4B</name>
        <entity>
          <protein>
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              <externalid>E1BPK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPFIA4</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LRRTM2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A6H701</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PTPRS</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398686</externalid>
        <name>LRFN1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3MZS2</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10390672</externalid>
        <entity>
          <protein>
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              <externalid>F1MMZ4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>EPB41L3</name>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>NRXN3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EPB41L1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IL1RAP</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKU4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS4</externalid>
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          </protein>
        </entity>
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          </protein>
        </entity>
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        <name>SH3GLB2</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>EPB41</name>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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          </protein>
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          </protein>
        </entity>
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          </protein>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1N164</externalid>
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          </protein>
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      <gene>
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          </protein>
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        <name>SHANK1</name>
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          </protein>
        </entity>
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      <gene>
        <externalid>10398694</externalid>
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              <externalid>E1BDP0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10338871</externalid>
        <name>PPFIBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390720</externalid>
        <name>HOMER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390784</externalid>
        <name>DLGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390728</externalid>
        <name>HOMER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390792</externalid>
        <name>DLGAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6794361</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388844</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8849932</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6794362</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112316</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6794361</externalid>
    <name>Neurexins and neuroligins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6794361</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10390686</externalid>
        <name>NLGN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q4B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390788</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390963</externalid>
        <name>LRRTM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390680</externalid>
        <name>NRXN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N119</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340248</externalid>
        <name>EPB41L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N611</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390724</externalid>
        <name>HOMER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LHC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331523</externalid>
        <name>SH3GLB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7N7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390762</externalid>
        <name>EPB41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9N179</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390955</externalid>
        <name>LRRTM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390766</externalid>
        <name>EPB41L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390692</externalid>
        <name>NLGN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390967</externalid>
        <name>LRRTM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390816</externalid>
        <name>SHANK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7P4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390774</externalid>
        <name>EPB41L5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337951</externalid>
        <name>CASK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390698</externalid>
        <name>NLGN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334985</externalid>
        <name>GRM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1H2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334981</externalid>
        <name>GRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390808</externalid>
        <name>SHANK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E618</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390812</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390720</externalid>
        <name>HOMER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390784</externalid>
        <name>DLGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390728</externalid>
        <name>HOMER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390959</externalid>
        <name>LRRTM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390792</externalid>
        <name>DLGAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390770</externalid>
        <name>EPB41L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7S3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6794361</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6794362</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-388844</externalid>
    <name>Receptor-type tyrosine-protein phosphatases</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-388844</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10338875</externalid>
        <name>PPFIBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332946</externalid>
        <name>PPFIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N164</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390921</externalid>
        <name>SLITRK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390917</externalid>
        <name>SLITRK5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344044</externalid>
        <name>IL1RAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390901</externalid>
        <name>SLITRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332954</externalid>
        <name>PPFIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390909</externalid>
        <name>SLITRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N513</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367297</externalid>
        <name>NTRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338885</externalid>
        <name>PTPRD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390913</externalid>
        <name>SLITRK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5L8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391014</externalid>
        <name>LRRC4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338871</externalid>
        <name>PPFIBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332958</externalid>
        <name>PPFIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332950</externalid>
        <name>PPFIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10390905</externalid>
        <name>LOC101901895</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2N1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316678</externalid>
        <name>PTPRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338889</externalid>
        <name>PTPRS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-388844</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6794362</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8849932</externalid>
    <name>Synaptic adhesion-like molecules</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8849932</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10398694</externalid>
        <name>LRFN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338885</externalid>
        <name>PTPRD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340280</externalid>
        <name>DLG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340256</externalid>
        <name>DLG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380055</externalid>
        <name>FLOT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343034</externalid>
        <name>DLG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398698</externalid>
        <name>LRFN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380059</externalid>
        <name>FLOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLR4</externalid>
            </xref>
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        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173782</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5653656</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-199991</externalid>
    <name>Membrane Trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-199991</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>TUBB2A</name>
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          <protein>
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              <externalid>E1BJB1</externalid>
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      <gene>
        <externalid>10341408</externalid>
        <name>TBC1D8B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSJ6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>GRB2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
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      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
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              <externalid>P48018</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10386788</externalid>
        <name>COPS8</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV74</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SEC24B</name>
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              <externalid>E1BPR4</externalid>
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      <gene>
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      <gene>
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        <name>NECAP1</name>
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              <externalid>Q3T093</externalid>
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      <gene>
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              <externalid>Q2HJB8</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>E1BDC9</externalid>
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      <gene>
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      <gene>
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        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331836</externalid>
        <name>SEC31A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401683</externalid>
        <name>GAPVD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D794</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397363</externalid>
        <name>GOLGA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399764</externalid>
        <name>TBC1D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-199977</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6811442</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199992</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157858</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8856828</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-917729</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9007101</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-199991</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5653656</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-199977</externalid>
    <name>ER to Golgi Anterograde Transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-199977</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>E1BJB1</externalid>
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      <gene>
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        <name>TRAPPC6A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T086</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>KDELR1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>DCTN6</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q148G7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TFG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SX36</externalid>
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          </protein>
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      <gene>
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        <name>TMED3</name>
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          <protein>
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              <externalid>A0A3Q1LXI8</externalid>
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          </protein>
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      <gene>
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        <name>SEC24B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BPR4</externalid>
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          </protein>
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      <gene>
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        <name>BET1L</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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              <externalid>Q2HJB8</externalid>
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      <gene>
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              <externalid>A0A3Q1M7M6</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>GORASP1</name>
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      <gene>
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        <name>TMED9</name>
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              <externalid>Q3T133</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366938</externalid>
        <name>RAB1B</name>
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              <externalid>A0A3Q1MWA3</externalid>
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          </protein>
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        </entity>
      </gene>
      <gene>
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        <name>COG2</name>
        <entity>
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              <externalid>F1MQ89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEC16A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6K7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MCFD2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395632</externalid>
        <name>COPE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28104</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E666</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331857</externalid>
        <name>SEC22C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331982</externalid>
        <name>CD59</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395624</externalid>
        <name>COPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T856</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387499</externalid>
        <name>TRAPPC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTG7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337719</externalid>
        <name>ACTR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TUBB4A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BGA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MIA2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>SPTA1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>ARFGAP2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWK0</externalid>
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          </protein>
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      <gene>
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        <name>SEC24A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>SEC31A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BMP2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEC13</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>NAPG</name>
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          <protein>
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          </protein>
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    </genes>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
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      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-204005</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807878</externalid>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-199977</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-948021</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    </biosystemtype>
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      <taxnode>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1ME46</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD1</externalid>
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          </protein>
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      <gene>
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        <name>RAB1B</name>
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          <protein>
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              <externalid>A0A3Q1LUP7</externalid>
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          </protein>
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      <gene>
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        <name>AREG</name>
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              <externalid>F1MEV4</externalid>
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      <gene>
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      <gene>
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              <externalid>Q3T0T7</externalid>
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        <name>CTSZ</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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              <externalid>F1MV07</externalid>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>A6QNT8</externalid>
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      <gene>
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        <name>F5</name>
        <entity>
          <protein>
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              <externalid>F1N0I3</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>GTP(4-)</name>
        <xref>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199977</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-204005</externalid>
    <name>COPII-mediated vesicle transport</name>
    <biosystemtype>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-204005</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>GOSR2</name>
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          <protein>
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              <externalid>F1N652</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387599</externalid>
        <name>SCFD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332017</externalid>
        <name>SERPINA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P34955</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387503</externalid>
        <name>TRAPPC6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T086</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387507</externalid>
        <name>TRAPPC6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387479</externalid>
        <name>TRAPPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331951</externalid>
        <name>RAB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUP7</externalid>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>NSF</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>TBC1D20</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <smallmolecules>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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        <externalid>R-HSA-204005</externalid>
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      <linkedsystem>
        <externalid>R-BTA-199977</externalid>
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    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-6807878</externalid>
    <name>COPI-mediated anterograde transport</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6807878</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>GOSR2</name>
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              <externalid>F1N652</externalid>
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              <externalid>E1BJB1</externalid>
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              <externalid>F1N5R4</externalid>
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              <externalid>G3N173</externalid>
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      <gene>
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        <name>KDELR1</name>
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        <name>DYNC1LI2</name>
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              <externalid>F1MBQ0</externalid>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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        <name>arachidonoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57368</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-6811440</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6811438</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8856688</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6811442</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6811440</externalid>
    <name>Retrograde transport at the Trans-Golgi-Network</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6811440</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10395883</externalid>
        <name>COG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397307</externalid>
        <name>VTI1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397797</externalid>
        <name>RHOBTB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395871</externalid>
        <name>COG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N173</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397335</externalid>
        <name>SYS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397381</externalid>
        <name>TMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397279</externalid>
        <name>VPS52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341394</externalid>
        <name>IGF2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395875</externalid>
        <name>COG6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLE3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397238</externalid>
        <name>RAB6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397246</externalid>
        <name>RGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MND0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397275</externalid>
        <name>VPS51</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ84</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340480</externalid>
        <name>NSF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397339</externalid>
        <name>ARFRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397348</externalid>
        <name>ARL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDM1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397369</externalid>
        <name>GCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397790</externalid>
        <name>RABEPK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387583</externalid>
        <name>NAPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391580</externalid>
        <name>RAB6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397287</externalid>
        <name>VPS53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397283</externalid>
        <name>VPS54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395859</externalid>
        <name>COG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ89</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397250</externalid>
        <name>RIC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391550</externalid>
        <name>RAB9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397303</externalid>
        <name>STX16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIQ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395867</externalid>
        <name>COG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343125</externalid>
        <name>M6PR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397528</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9K7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397311</externalid>
        <name>STX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE18</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397375</externalid>
        <name>GCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395879</externalid>
        <name>COG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DKB6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342617</externalid>
        <name>NAPA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q334</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395863</externalid>
        <name>COG3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397357</externalid>
        <name>GOLGA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPM7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395855</externalid>
        <name>COG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK29</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397520</externalid>
        <name>ARFIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCL5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397293</externalid>
        <name>VAMP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397778</externalid>
        <name>M6PRBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX32</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>STX10</name>
        <entity>
          <protein>
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              <externalid>E1BQ02</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GOLGA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BFF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAB9A</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q08DW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NAPG</name>
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          <protein>
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              <externalid>A0A3Q1M5V0</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6811440</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6811442</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Intra-Golgi traffic</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6811438</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>GOSR2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N652</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395993</externalid>
        <name>GOSR1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2TBU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395883</externalid>
        <name>COG8</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N5R4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10397307</externalid>
        <name>VTI1A</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LTE3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395871</externalid>
        <name>COG5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N173</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>F1MDA6</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10398051</externalid>
        <name>RAB33B</name>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <externalid>F1N082</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398018</externalid>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MCV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COG6</name>
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          <protein>
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              <externalid>F1MLE3</externalid>
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        </entity>
      </gene>
      <gene>
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        <name>RGP1</name>
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              <externalid>F1MND0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398651</externalid>
        <name>RAB30</name>
        <entity>
          <protein>
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              <externalid>Q17QB7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BET1L</name>
        <entity>
          <protein>
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              <externalid>Q3MHP8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CYTH3</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1NJF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340480</externalid>
        <name>NSF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331848</externalid>
        <name>YKT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T000</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387583</externalid>
        <name>NAPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81126</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397250</externalid>
        <name>RIC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395859</externalid>
        <name>COG2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SNAP29</name>
        <entity>
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          </protein>
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      <gene>
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        <name>RAB39A</name>
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      <smallmolecule>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARF4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COPE</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GBF1</name>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>PAFAH1B1</name>
        <entity>
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          </protein>
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      </gene>
      <gene>
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        <name>TUBB2A</name>
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          </protein>
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      </gene>
      <gene>
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        <name>RAB18</name>
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          </protein>
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      </gene>
      <gene>
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        <name>PAFAH1B3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          </protein>
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      <gene>
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        <name>BICD2</name>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>TUBAL3</name>
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      <gene>
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      <gene>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>coenzyme A(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
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      </smallmolecule>
      <smallmolecule>
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        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760758</externalid>
        <name>arachidonoyl-CoA(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
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    </smallmolecules>
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        <externalid>R-HSA-6811436</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8856688</externalid>
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    </linkedsystems>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-199992</url>
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          </protein>
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          </protein>
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          </protein>
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        <name>BLOC1S3</name>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      </gene>
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          </protein>
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      <gene>
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        <name>CLTB</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377739</externalid>
        <name>CLVS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341332</externalid>
        <name>AP3S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341284</externalid>
        <name>AP1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343125</externalid>
        <name>M6PR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341374</externalid>
        <name>SORT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343159</externalid>
        <name>GNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342617</externalid>
        <name>NAPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q334</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341404</externalid>
        <name>TPD52L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402481</externalid>
        <name>ACBD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341298</externalid>
        <name>AP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341292</externalid>
        <name>AP1S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335794</externalid>
        <name>SNAP23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341400</externalid>
        <name>TPD52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341312</externalid>
        <name>CPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377106</externalid>
        <name>AP4S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M952</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320433</externalid>
        <name>STX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341394</externalid>
        <name>IGF2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341288</externalid>
        <name>AP1S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377743</externalid>
        <name>CLVS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341378</externalid>
        <name>SNX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341338</externalid>
        <name>AP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332012</externalid>
        <name>CTSZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05689</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341390</externalid>
        <name>TFRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335800</externalid>
        <name>VAMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341366</externalid>
        <name>YIPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341320</externalid>
        <name>SNX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342637</externalid>
        <name>CNO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342621</externalid>
        <name>BLOC1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342641</externalid>
        <name>TXNDC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341342</externalid>
        <name>AP4E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334440</externalid>
        <name>GBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377102</externalid>
        <name>AP4M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382999</externalid>
        <name>AP1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QYT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334430</externalid>
        <name>ARF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342629</externalid>
        <name>DTNBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-432722</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-432720</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-199992</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432722</externalid>
    <name>Golgi Associated Vesicle Biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-432722</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341350</externalid>
        <name>GAK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341274</externalid>
        <name>AP1M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341312</externalid>
        <name>CPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341354</externalid>
        <name>HIP1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341408</externalid>
        <name>TBC1D8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M952</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342633</externalid>
        <name>BLOC1S6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342625</externalid>
        <name>BLOC1S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341394</externalid>
        <name>IGF2R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341316</externalid>
        <name>PIK3C2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341288</externalid>
        <name>AP1S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341324</externalid>
        <name>AP3B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341378</externalid>
        <name>SNX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341338</externalid>
        <name>AP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341390</externalid>
        <name>TFRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335800</externalid>
        <name>VAMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326007</externalid>
        <name>SH3GL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341346</externalid>
        <name>NECAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T093</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341366</externalid>
        <name>YIPF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341370</externalid>
        <name>SNAPIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341320</externalid>
        <name>SNX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6W6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341328</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N380</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341278</externalid>
        <name>AP1M2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342637</externalid>
        <name>CNO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341382</externalid>
        <name>SNX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342621</externalid>
        <name>BLOC1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342641</externalid>
        <name>TXNDC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395893</externalid>
        <name>GOLGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341342</externalid>
        <name>AP4E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341332</externalid>
        <name>AP3S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341284</externalid>
        <name>AP1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341374</externalid>
        <name>SORT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342617</externalid>
        <name>NAPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q334</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341404</externalid>
        <name>TPD52L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LYV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402481</externalid>
        <name>ACBD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341298</externalid>
        <name>AP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334430</externalid>
        <name>ARF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341292</externalid>
        <name>AP1S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342629</externalid>
        <name>DTNBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341400</externalid>
        <name>TPD52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432722</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199992</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-432720</externalid>
    <name>Lysosome Vesicle Biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-432720</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10341274</externalid>
        <name>AP1M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377106</externalid>
        <name>AP4S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341270</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M952</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343155</externalid>
        <name>DNASE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341288</externalid>
        <name>AP1S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377743</externalid>
        <name>CLVS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341338</externalid>
        <name>AP4B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332012</externalid>
        <name>CTSZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05689</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335800</externalid>
        <name>VAMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332914</externalid>
        <name>VAMP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63026</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>SH3GL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
        <name>ARRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP1M2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342621</externalid>
        <name>BLOC1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKW0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CLTB</name>
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          <protein>
            <xref>
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              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TXNDC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP4E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLVS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BE20</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLTC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>M6PR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11456</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341284</externalid>
        <name>AP1S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP4M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343159</externalid>
        <name>GNS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QYT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334430</externalid>
        <name>ARF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84080</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AP1S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760868</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57923</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-432720</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199992</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-157858</externalid>
    <name>Gap junction trafficking and regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-157858</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327295</externalid>
        <name>GJB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327335</externalid>
        <name>GJA10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MYO6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A498UZ20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJB5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Z5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O18968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF19</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DNM1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>CLTA</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA5</name>
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              <externalid>F1MHC7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLTB</name>
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          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P41987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327198</externalid>
        <name>DAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N371</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327319</externalid>
        <name>GJD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q866T7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327315</externalid>
        <name>GJA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHI7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327327</externalid>
        <name>GJC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-BTA-190828</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-191650</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-157858</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190828</externalid>
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    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190828</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>GJB4</name>
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          <protein>
            <xref>
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          </protein>
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      </gene>
      <gene>
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        <name>GJA1</name>
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          <protein>
            <xref>
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              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLU3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10327216</externalid>
        <name>MYO6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A498UZ20</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
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          <protein>
            <xref>
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              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345366</externalid>
        <name>GJB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE67</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327291</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1N8</externalid>
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          </protein>
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      <gene>
        <externalid>10327287</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>O18968</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10327331</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q08DF4</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>AP2M1</name>
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              <externalid>Q3ZC13</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>Q58D78</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>Q2HJ66</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>GJA9</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA3</name>
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          <protein>
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              <externalid>P41987</externalid>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLTC</name>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA8</name>
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          <protein>
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              <externalid>F1MHI7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GJA4</name>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
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        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190873</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157858</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Gap junction assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-190861</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>E1BPE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
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              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327323</externalid>
        <name>GJA9</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N617</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327335</externalid>
        <name>GJA10</name>
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          <protein>
            <xref>
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              <externalid>E1BLU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327307</externalid>
        <name>GJA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327311</externalid>
        <name>GJA3</name>
        <entity>
          <protein>
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              <externalid>P41987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345366</externalid>
        <name>GJB2</name>
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            <xref>
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              <externalid>A2VE67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327291</externalid>
        <name>GJB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327287</externalid>
        <name>GJB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327319</externalid>
        <name>GJD2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q866T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327274</externalid>
        <name>GJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327331</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327315</externalid>
        <name>GJA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327303</externalid>
        <name>GJA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327299</externalid>
        <name>GJB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327327</externalid>
        <name>GJC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190704</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190872</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190861</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190828</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190704</externalid>
    <name>Oligomerization of connexins into connexons</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190704</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327274</externalid>
        <name>GJB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190704</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190861</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190872</externalid>
    <name>Transport of connexons to the plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190872</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345366</externalid>
        <name>GJB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-190840</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190872</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190861</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190840</externalid>
    <name>Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190840</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-190840</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190872</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-190873</externalid>
    <name>Gap junction degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-190873</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327166</externalid>
        <name>CLTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327216</externalid>
        <name>MYO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A498UZ20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327198</externalid>
        <name>DAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N371</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-196025</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-190873</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190828</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-196025</externalid>
    <name>Formation of annular gap junctions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-196025</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10325999</externalid>
        <name>CLTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49951</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327166</externalid>
        <name>CLTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325975</externalid>
        <name>AP2M1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327198</externalid>
        <name>DAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N371</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325995</externalid>
        <name>CLTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-196025</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-190873</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-191650</externalid>
    <name>Regulation of gap junction activity</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-191650</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327184</externalid>
        <name>GJA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-191650</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-157858</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8856828</externalid>
    <name>Clathrin-mediated endocytosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8856828</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10341358</externalid>
        <name>OCRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374126</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326381</externalid>
        <name>SH3GL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326054</externalid>
        <name>BTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386772</externalid>
        <name>COPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401358</externalid>
        <name>PACSIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401074</externalid>
        <name>UBQLN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401439</externalid>
        <name>HIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>102804</externalid>
        <name>SYT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48018</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386788</externalid>
        <name>COPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386796</externalid>
        <name>COPS7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QE33</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331604</externalid>
        <name>WASL</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95107</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T093</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340519</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17870</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10400172</externalid>
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          <protein>
            <xref>
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              <externalid>A0A3Q1LK58</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400583</externalid>
        <name>SYT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386784</externalid>
        <name>COPS6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327166</externalid>
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          <protein>
            <xref>
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              <externalid>P04975</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>217376</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326349</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RS49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386768</externalid>
        <name>COPS2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X736</externalid>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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        <name>FNBP1</name>
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              <externalid>G5E6K6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RAB5B</name>
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          </protein>
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      </gene>
      <gene>
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        <name>COPS5</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>ACTB</name>
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          </protein>
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      <gene>
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        <name>CBL</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>LDLR</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>KIAA0319</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
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          <externalid>71406</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
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          <externalid>72587</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <externalid>37565</externalid>
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      <smallmolecule>
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          <externalid>30616</externalid>
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      <smallmolecule>
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        <name>phospholipid</name>
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      <smallmolecule>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
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      <smallmolecule>
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        <name>cholesterol</name>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
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    <name>Cargo recognition for clathrin-mediated endocytosis</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8856825</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q3T0F9</externalid>
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              <externalid>A4FV74</externalid>
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              <externalid>P17870</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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              <externalid>F1MRS2</externalid>
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      <gene>
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              <externalid>F1MG10</externalid>
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          </protein>
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        <name>CLTB</name>
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              <externalid>P04975</externalid>
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              <externalid>G3X736</externalid>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400645</externalid>
        <name>TOR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386792</externalid>
        <name>GPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340969</externalid>
        <name>ITSN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8856825</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8856828</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-917729</externalid>
    <name>Endosomal Sorting Complex Required For Transport (ESCRT)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-917729</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348625</externalid>
        <name>CHMP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H704</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348748</externalid>
        <name>MVB12B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348607</externalid>
        <name>CHMP4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDY3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348709</externalid>
        <name>VTA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N318</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348718</externalid>
        <name>VPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T178</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348722</externalid>
        <name>TSG101</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348593</externalid>
        <name>CHMP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348744</externalid>
        <name>MVB12A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0N1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348764</externalid>
        <name>SNF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348603</externalid>
        <name>CHMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348754</externalid>
        <name>UBAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2K6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348621</externalid>
        <name>CHMP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348772</externalid>
        <name>VPS36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348615</externalid>
        <name>CHMP4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348611</externalid>
        <name>CHMP4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326349</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RS49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348697</externalid>
        <name>VPS4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X8E2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348701</externalid>
        <name>VPS4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348597</externalid>
        <name>CHMP2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326353</externalid>
        <name>STAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N315</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348734</externalid>
        <name>VPS37C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326345</externalid>
        <name>HGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348730</externalid>
        <name>VPS37B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348726</externalid>
        <name>VPS37A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348738</externalid>
        <name>VPS37D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348705</externalid>
        <name>CHMP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348768</externalid>
        <name>VPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-917729</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9007101</externalid>
    <name>Rab regulation of trafficking</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9007101</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10402840</externalid>
        <name>DENND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402942</externalid>
        <name>ANKRD27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N642</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401835</externalid>
        <name>RAB13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403033</externalid>
        <name>MON1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403152</externalid>
        <name>DENND5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403121</externalid>
        <name>HPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399896</externalid>
        <name>RAB11B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397238</externalid>
        <name>RAB6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397246</externalid>
        <name>RGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MND0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402740</externalid>
        <name>DENND4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402763</externalid>
        <name>DENND1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402576</externalid>
        <name>RIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368756</externalid>
        <name>OPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402905</externalid>
        <name>DENND6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399751</externalid>
        <name>SYTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391566</externalid>
        <name>RAB31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399733</externalid>
        <name>RAB8B</name>
        <entity>
          <protein>
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      <gene>
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        <name>GAPVD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D794</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399904</externalid>
        <name>TBC1D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397768</externalid>
        <name>RAB9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399764</externalid>
        <name>TBC1D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8876198</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8854214</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9007101</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-199991</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8876198</externalid>
    <name>RAB GEFs exchange GTP for GDP on RABs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8876198</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10402840</externalid>
        <name>DENND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402942</externalid>
        <name>ANKRD27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N642</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401835</externalid>
        <name>RAB13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403033</externalid>
        <name>MON1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LP41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403152</externalid>
        <name>DENND5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403121</externalid>
        <name>HPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397238</externalid>
        <name>RAB6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402763</externalid>
        <name>DENND1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397246</externalid>
        <name>RGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MND0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402576</externalid>
        <name>RIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402740</externalid>
        <name>DENND4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402905</externalid>
        <name>DENND6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391566</externalid>
        <name>RAB31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399733</externalid>
        <name>RAB8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391558</externalid>
        <name>RAB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391550</externalid>
        <name>RAB9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398663</externalid>
        <name>RAB39A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402901</externalid>
        <name>DENND6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402794</externalid>
        <name>DENND2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402786</externalid>
        <name>DENND2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8H4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402798</externalid>
        <name>DENND2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1V1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403025</externalid>
        <name>CCZ1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402531</externalid>
        <name>GDI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21856</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392220</externalid>
        <name>GDI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403029</externalid>
        <name>MON1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401913</externalid>
        <name>RAB32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391576</externalid>
        <name>RAB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379801</externalid>
        <name>RAB3IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398606</externalid>
        <name>RAB3GAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401893</externalid>
        <name>RAB21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380874</externalid>
        <name>MADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391562</externalid>
        <name>RAB18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402732</externalid>
        <name>DENND4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392686</externalid>
        <name>RAB27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399797</externalid>
        <name>RAB7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401839</externalid>
        <name>RAB38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9C0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402549</externalid>
        <name>RAB3IL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403125</externalid>
        <name>HPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N720</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398602</externalid>
        <name>RAB3GAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402600</externalid>
        <name>RINL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402572</externalid>
        <name>BRMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402596</externalid>
        <name>RABGEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346112</externalid>
        <name>RAB27B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403056</externalid>
        <name>DENND1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402790</externalid>
        <name>ST5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394442</externalid>
        <name>CHM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396868</externalid>
        <name>SBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399701</externalid>
        <name>RAB35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401817</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2I0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402590</externalid>
        <name>ALS2CL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391580</externalid>
        <name>RAB6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403148</externalid>
        <name>DENND5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402948</externalid>
        <name>SBF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403052</externalid>
        <name>DENND1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402736</externalid>
        <name>DENND4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N377</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397250</externalid>
        <name>RIC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402584</externalid>
        <name>ALS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368760</externalid>
        <name>RAB8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358922</externalid>
        <name>ULK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402580</externalid>
        <name>RIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5D0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401871</externalid>
        <name>RAB12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353112</externalid>
        <name>RAB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401933</externalid>
        <name>RAB39B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391924</externalid>
        <name>RAB14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366862</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316913</externalid>
        <name>YWHAE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401683</externalid>
        <name>GAPVD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D794</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397768</externalid>
        <name>RAB9A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8876198</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9007101</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8854214</externalid>
    <name>TBC/RABGAPs</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8854214</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383871</externalid>
        <name>GABARAPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P60519</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399781</externalid>
        <name>TBC1D7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398051</externalid>
        <name>RAB33B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399797</externalid>
        <name>RAB7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399720</externalid>
        <name>TBC1D13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399896</externalid>
        <name>RAB11B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399848</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397238</externalid>
        <name>RAB6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368756</externalid>
        <name>OPTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399701</externalid>
        <name>RAB35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399751</externalid>
        <name>SYTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399733</externalid>
        <name>RAB8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391580</externalid>
        <name>RAB6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383863</externalid>
        <name>GABARAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GJW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368760</externalid>
        <name>RAB8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393964</externalid>
        <name>TBC1D10C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358922</externalid>
        <name>ULK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323255</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399743</externalid>
        <name>TBC1D17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399710</externalid>
        <name>TBC1D10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399771</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3N1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399789</externalid>
        <name>RABGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N746</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399808</externalid>
        <name>TBC1D15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399837</externalid>
        <name>RAB4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399855</externalid>
        <name>RAB33A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323267</externalid>
        <name>TSC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366862</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399829</externalid>
        <name>TBC1D25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376349</externalid>
        <name>MAP1LC3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O41515</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399714</externalid>
        <name>TBC1D10B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399904</externalid>
        <name>TBC1D14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399764</externalid>
        <name>TBC1D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8854214</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9007101</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2173782</externalid>
    <name>Binding and Uptake of Ligands by Scavenger Receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2173782</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365601</externalid>
        <name>STAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366963</externalid>
        <name>CD163</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P85521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345734</externalid>
        <name>SPARC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13213</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366575</externalid>
        <name>COLEC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366715</externalid>
        <name>STAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334264</externalid>
        <name>SCARB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18824</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420241</externalid>
        <name>CD5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354357</externalid>
        <name>HBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02070</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354351</externalid>
        <name>HBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366190</externalid>
        <name>HPX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372003</externalid>
        <name>PRDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E947</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378887</externalid>
        <name>S100A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366208</externalid>
        <name>LRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2168880</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3000480</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3000471</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3000497</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2173782</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5653656</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2168880</externalid>
    <name>Scavenging of heme from plasma</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2168880</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10366963</externalid>
        <name>CD163</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P85521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354357</externalid>
        <name>HBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02070</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354351</externalid>
        <name>HBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366190</externalid>
        <name>HPX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366208</externalid>
        <name>LRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>198830</externalid>
        <name>ferriheme b</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36144</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2168880</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173782</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3000480</externalid>
    <name>Scavenging by Class A Receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3000480</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366575</externalid>
        <name>COLEC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31285</externalid>
        <name>N-acetyl-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3000480</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173782</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3000471</externalid>
    <name>Scavenging by Class B Receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3000471</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334264</externalid>
        <name>SCARB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O18824</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420241</externalid>
        <name>CD5L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372003</externalid>
        <name>PRDX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E947</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378887</externalid>
        <name>S100A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174780</externalid>
        <name>long-chain fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15904</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3000471</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173782</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3000497</externalid>
    <name>Scavenging by Class H Receptors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3000497</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10365601</externalid>
        <name>STAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345734</externalid>
        <name>SPARC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13213</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366715</externalid>
        <name>STAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444769</externalid>
        <name>chondroitin sulfate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37397</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3000497</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173782</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4839726</externalid>
    <name>Chromatin organization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4839726</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>231417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0S9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353665</externalid>
        <name>PADI2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375507</externalid>
        <name>JMJD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJR2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352910</externalid>
        <name>HMG20B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L68</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334290</externalid>
        <name>HDAC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370570</externalid>
        <name>COPRS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375667</externalid>
        <name>SETDB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKH5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353673</externalid>
        <name>PADI4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCN3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375496</externalid>
        <name>PHF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341981</externalid>
        <name>SUV39H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6G5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MTA3</name>
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          <protein>
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              <externalid>A0A3Q1M2W8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG44</externalid>
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          </protein>
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      <gene>
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        <name>ING4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MD09</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PAX3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MTX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KAT6A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BEB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ95</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM5C</name>
        <entity>
          <protein>
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              <externalid>F1MYV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N346</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GATAD2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPD8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>NCOR1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
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              <externalid>G3MXT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371568</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q2KII5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MYST2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>P63258</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SMYD3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5C5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>F1MUR2</externalid>
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          </protein>
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      <gene>
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        <name>NFKB2</name>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>HDAC2</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>EP300</name>
        <entity>
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              <externalid>E1B8D6</externalid>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
        <entity>
          <protein>
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              <externalid>F2Z4F9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WDR77</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375459</externalid>
        <name>KDM4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>SMARCC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRMT1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>NSD3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>JADE2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTL6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRMT5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ING5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>MCRS1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>KAT8</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SMARCA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SMARCD3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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      <gene>
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        <name>ATF7IP</name>
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      <gene>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
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      <linkedsystem>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-4839726</externalid>
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    <name>Chromatin modifying enzymes</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3247509</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CCND1</name>
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        <name>COPRS</name>
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      <gene>
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        <name>LOC528006</name>
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              <externalid>Q0VBX4</externalid>
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      <gene>
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        <name>PADI4</name>
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      <gene>
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        <name>PHF2</name>
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              <externalid>F1MH71</externalid>
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      <gene>
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        <name>SUV39H1</name>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>E1BEB3</externalid>
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      <gene>
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              <externalid>Q2YDJ8</externalid>
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      <gene>
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        <name>KDM6B</name>
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              <externalid>G3N346</externalid>
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          </protein>
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      <gene>
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        <name>KDM5C</name>
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          <protein>
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              <externalid>F1MYV2</externalid>
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          </protein>
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      <gene>
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        <name>KDM1A</name>
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          <protein>
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              <externalid>F1MBS5</externalid>
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      <gene>
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        <name>GATAD2A</name>
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              <externalid>A0A3S5ZPD8</externalid>
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      <gene>
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        <name>NCOR1</name>
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              <externalid>F1MGM4</externalid>
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      <gene>
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      </gene>
      <gene>
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        <name>HIST1H2BI</name>
        <entity>
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              <externalid>Q2KII5</externalid>
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      <gene>
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        <name>H2AC21</name>
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              <externalid>E1BH22</externalid>
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      <gene>
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        <name>MYST2</name>
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          <protein>
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        <name>KDM4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350332</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ96</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370578</externalid>
        <name>SMARCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NSD3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BNH7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JADE2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JADE3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM4C</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT70</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTL6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRMT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ING5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371753</externalid>
        <name>MCRS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KAT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370590</externalid>
        <name>SMARCA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKK5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340176</externalid>
        <name>SMARCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0II51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMARCD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATF7IP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114764</externalid>
        <name>formaldehyde</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16842</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-3214847</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3214815</externalid>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-HSA-3247509</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4839726</externalid>
        <linkedsystemtype>
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    </linkedsystems>
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    <name>HATs acetylate histones</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3214847</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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        <name>HIST3H2A</name>
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              <externalid>A4IFU5</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>OGT</name>
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      <gene>
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        <name>HCFC1</name>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>NCOA1</name>
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      <gene>
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      <gene>
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        <name>ING4</name>
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      <gene>
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      <gene>
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        <name>BRPF1</name>
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              <externalid>A0A3Q1NAP3</externalid>
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          </protein>
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      <gene>
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        <name>PAX3</name>
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              <externalid>F1MTX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WDR5</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N3E5</externalid>
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          </protein>
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      <gene>
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        <name>KAT6A</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BEB3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
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              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>H2AC12</name>
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              <externalid>A0A3Q1MF62</externalid>
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          </protein>
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      <gene>
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        <name>KANSL1</name>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>PHF20</name>
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          <protein>
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              <externalid>E1BMS9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <externalid>G3MXT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371568</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC21</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MYST2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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        <name>MSL2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>MSL3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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        <entity>
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          </protein>
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          </protein>
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          </protein>
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      <smallmolecule>
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      <linkedsystem>
        <externalid>R-BTA-3247509</externalid>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3214815</url>
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              <externalid>F1N3F6</externalid>
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      <gene>
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              <externalid>F1MPA7</externalid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>MTA3</name>
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              <externalid>E1BDE9</externalid>
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      <gene>
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              <externalid>F1MFJ6</externalid>
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          </protein>
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      <gene>
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        <name>ARID4A</name>
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              <externalid>E1BGK1</externalid>
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          </protein>
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      <gene>
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        <name>SAP30</name>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372509</externalid>
        <name>H2AC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315852</externalid>
        <name>GATAD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352896</externalid>
        <name>RCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373191</externalid>
        <name>ARID4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MC43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>GATAD2A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>NCOR1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371568</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315834</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BRMS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>HDAC2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>HDAC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
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      <gene>
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        <name>TBL1X</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B7TCI5</externalid>
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          </protein>
        </entity>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>PHF21A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS13</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            <xref>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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        <name>HIST1H2BI</name>
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        <name>LOC614881</name>
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    </genes>
    <smallmolecules>
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        <xref>
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          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>4663843</externalid>
        <name>1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-)</name>
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          <externalid>57627</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3214815</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3247509</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3214842</externalid>
    <name>HDMs demethylate histones</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3214842</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>KDM5A</name>
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          </protein>
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      <gene>
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      <gene>
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        <name>KDM6A</name>
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              <externalid>A0A3Q1LHB0</externalid>
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          </protein>
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      <gene>
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          </protein>
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              <externalid>P68432</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>KDM2B</name>
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          <protein>
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              <externalid>E1BLZ5</externalid>
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          </protein>
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      <gene>
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              <externalid>P62803</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM4C</name>
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          <protein>
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              <externalid>A0A3Q1MT70</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>JMJD6</name>
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              <externalid>A0A452DJR2</externalid>
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          </protein>
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      <gene>
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        <name>KDM7A</name>
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          <protein>
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              <externalid>F1N542</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM5B</name>
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              <externalid>F1MUR2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RIOX2</name>
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              <externalid>A0A3Q1MI23</externalid>
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          </protein>
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      <gene>
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              <externalid>E1BE97</externalid>
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          </protein>
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      <gene>
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              <externalid>G3N346</externalid>
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      <gene>
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        <name>KDM5C</name>
        <entity>
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          </protein>
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      <gene>
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        <name>KDM4B</name>
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          </protein>
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      <gene>
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        <name>KDM3A</name>
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      <gene>
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      <gene>
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        <name>PHF2</name>
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      <gene>
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      <gene>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
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        <name>2-oxoglutarate(2-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>formaldehyde</name>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-3214842</externalid>
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      </linkedsystem>
      <linkedsystem>
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      <gene>
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      <smallmolecule>
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          <protein>
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          <protein>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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        <name>SMARCD3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>SMARCA4</name>
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          <protein>
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              <externalid>A7Z019</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTG9</externalid>
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          </protein>
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      <gene>
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        <name>SMARCC1</name>
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          <protein>
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              <externalid>F1MYU1</externalid>
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      <gene>
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          <protein>
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          <superset />
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      <gene>
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          <protein>
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          <protein>
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          <protein>
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      <gene>
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        <entity>
          <protein>
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          <protein>
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      <gene>
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          <protein>
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              <externalid>A5PJG3</externalid>
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              <externalid>E1BJB1</externalid>
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          <protein>
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              <externalid>E1BPK0</externalid>
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      <gene>
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              <externalid>E1BBU9</externalid>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CS</name>
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              <externalid>Q29RK1</externalid>
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          </protein>
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      <gene>
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        <name>H2B</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COG8</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FKTN</name>
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              <externalid>E1BBM2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>ASB8</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387627</externalid>
        <name>MIA3</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACADSB</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAD21</name>
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          <protein>
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              <externalid>Q3SWX9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N144</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
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      <gene>
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        <name>EIF3M</name>
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      </gene>
      <gene>
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              <externalid>G3MWN1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PHC3</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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      </gene>
      <gene>
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        <name>CUL4B</name>
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        </entity>
      </gene>
      <gene>
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      <gene>
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        <name>FBXW8</name>
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              <externalid>E1BGE6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADAMTS19</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N303</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
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          <protein>
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              <externalid>Q1RMX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZDHHC2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3MXF3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322914</externalid>
        <name>NDUFS3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315277</externalid>
        <name>RPL28</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ34</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404207</externalid>
        <name>LY6E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMM2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370165</externalid>
        <name>CTBP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336253</externalid>
        <name>ADORA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341609</externalid>
        <name>SPCS2</name>
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          <protein>
            <xref>
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              <externalid>E1BEI2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313614</externalid>
        <name>FH</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q148D3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346112</externalid>
        <name>RAB27B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386930</externalid>
        <name>ABRAXAS2</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DERL1</name>
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          <protein>
            <xref>
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              <externalid>Q71SS4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369685</externalid>
        <name>SENP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404222</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1N8V4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385781</externalid>
        <name>YY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330780</externalid>
        <name>FSTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D84</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385447</externalid>
        <name>JOSD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME39</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MVK1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386792</externalid>
        <name>GPS1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1ME43</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549017</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549011</externalid>
        <name>N-{alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29866</externalid>
        <name>N-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841147</externalid>
        <name>L-beta-isoaspartate residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8980584</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53058</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549023</externalid>
        <name>N-{alpha-Glc-(1-&gt;2)-alpha-Glc-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc} group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332985</externalid>
        <name>(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687527</externalid>
        <name>N-methyl-D-aspartic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114825</externalid>
        <name>2-trans,6-trans,10-trans-geranylgeranyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48861</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36219</externalid>
        <name>diacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549013</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788888</externalid>
        <name>psicosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87176</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940812</externalid>
        <name>D-ribitol 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57695</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788887</externalid>
        <name>psicosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9853732</externalid>
        <name>ferroheme b(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60344</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788757</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine methyl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37949</externalid>
        <name>(alpha-D-mannosyl)4-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767878</externalid>
        <name>6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332984</externalid>
        <name>bicyclo[3.3.0]oct-2-ene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788891</externalid>
        <name>ribulosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676935</externalid>
        <name>L-methionine (S)-S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37945</externalid>
        <name>beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162763</externalid>
        <name>6-O-[alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767880</externalid>
        <name>6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57265</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788766</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449253</externalid>
        <name>glycan G10595</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031635</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422040</externalid>
        <name>octanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676947</externalid>
        <name>L-methionine (R)-S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549012</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549010</externalid>
        <name>alpha-Gal-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162846</externalid>
        <name>acylglucosaminylphosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549019</externalid>
        <name>alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-D-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788892</externalid>
        <name>ribulosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855698</externalid>
        <name>proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940862</externalid>
        <name>CDP-ribitol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861836</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31055</externalid>
        <name>trimethylenediamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449634</externalid>
        <name>glycan G10599</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5691515</externalid>
        <name>N-terminal N-acetyl-L-serine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83690</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861833</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449308</externalid>
        <name>N-acetyl-D-glucosaminyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861835</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91283</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39257</externalid>
        <name>rifampicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162782</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391251</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-381426</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5676934</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5683826</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9837999</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-392499</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72766</externalid>
    <name>Translation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72766</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420395</externalid>
        <name>ZNF598</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393798</externalid>
        <name>TRMT112</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321659</externalid>
        <name>EEF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245923</externalid>
        <name>MRPL16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245914</externalid>
        <name>MRPL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378750</externalid>
        <name>OXA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
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      <smallmolecule>
        <externalid>5691515</externalid>
        <name>N-terminal N-acetyl-L-serine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83690</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-379724</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72613</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1799339</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156842</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72764</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5368287</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9948299</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72766</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379724</externalid>
    <name>tRNA Aminoacylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379724</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344895</externalid>
        <name>PPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314244</externalid>
        <name>PPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P37980</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-379716</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379726</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-379724</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379716</externalid>
    <name>Cytosolic tRNA aminoacylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379716</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314244</externalid>
        <name>PPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P37980</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-379716</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379724</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-379726</externalid>
    <name>Mitochondrial tRNA aminoacylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-379726</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344895</externalid>
        <name>PPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-379726</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-379724</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72613</externalid>
    <name>Eukaryotic Translation Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72613</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315191</externalid>
        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315137</externalid>
        <name>EIF2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315411</externalid>
        <name>RPL36A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315281</externalid>
        <name>RPL29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315265</externalid>
        <name>RPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q862I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315299</externalid>
        <name>RPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>F1MK30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315155</externalid>
        <name>RPLP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P42899</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315427</externalid>
        <name>RPL39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T051</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315167</externalid>
        <name>RPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61284</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315105</externalid>
        <name>EIF4EBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315323</externalid>
        <name>RPL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315217</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315229</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315331</externalid>
        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156827</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72613</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72737</externalid>
    <name>Cap-dependent Translation Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72737</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315191</externalid>
        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315137</externalid>
        <name>EIF2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315411</externalid>
        <name>RPL36A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315281</externalid>
        <name>RPL29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315265</externalid>
        <name>RPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q862I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315299</externalid>
        <name>RPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315383</externalid>
        <name>RPL26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315319</externalid>
        <name>RPL38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315041</externalid>
        <name>EIF1AX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315159</externalid>
        <name>RPL10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315225</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315209</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315397</externalid>
        <name>RPL3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315335</externalid>
        <name>RPL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315315</externalid>
        <name>RPL37A</name>
        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315217</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS13</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>RPL27</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
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          <externalid>37565</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-72689</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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          <subset />
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      <linkedsystem>
        <externalid>R-HSA-72737</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72613</externalid>
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    </linkedsystems>
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    <externalid>R-BTA-72689</externalid>
    <name>Formation of a pool of free 40S subunits</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72689</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>EIF3L</name>
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          <protein>
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        <name>EIF3F</name>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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        <name>EIF1AX</name>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          <protein>
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          </protein>
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          <protein>
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          </protein>
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      <gene>
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        <name>EIF3J</name>
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          </protein>
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          </protein>
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          </protein>
        </entity>
      </gene>
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        <entity>
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          </protein>
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        <name>EIF3B</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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          </protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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          </protein>
        </entity>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315009</externalid>
        <name>EIF3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T122</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>EIF3C</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>EIF3M</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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    </genes>
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      </linkedsystem>
      <linkedsystem>
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    <name>Formation of the ternary complex, and subsequently, the 43S complex</name>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72695</url>
    <taxonomy>
      <taxnode>
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              <externalid>E1BLZ8</externalid>
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              <externalid>Q3SYW6</externalid>
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        <name>EIF2S2</name>
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              <externalid>A6QLG5</externalid>
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        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314891</externalid>
        <name>RPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315001</externalid>
        <name>EIF3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315033</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315029</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315021</externalid>
        <name>EIF3K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315041</externalid>
        <name>EIF1AX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314989</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314981</externalid>
        <name>EIF3J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314997</externalid>
        <name>EIF3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315009</externalid>
        <name>EIF3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314985</externalid>
        <name>EIF3I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72695</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72662</externalid>
    <name>Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72662</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314877</externalid>
        <name>RPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314957</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315013</externalid>
        <name>EIF3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314891</externalid>
        <name>RPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315001</externalid>
        <name>EIF3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315033</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315029</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315021</externalid>
        <name>EIF3K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315041</externalid>
        <name>EIF1AX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314989</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314981</externalid>
        <name>EIF3J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314997</externalid>
        <name>EIF3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315085</externalid>
        <name>EIF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315105</externalid>
        <name>EIF4EBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5A7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315009</externalid>
        <name>EIF3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314985</externalid>
        <name>EIF3I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315089</externalid>
        <name>EIF4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-72649</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-72662</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72649</externalid>
    <name>Translation initiation complex formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72649</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314877</externalid>
        <name>RPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314957</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315013</externalid>
        <name>EIF3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314891</externalid>
        <name>RPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315001</externalid>
        <name>EIF3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315033</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315029</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315021</externalid>
        <name>EIF3K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315041</externalid>
        <name>EIF1AX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314989</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314981</externalid>
        <name>EIF3J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314997</externalid>
        <name>EIF3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315085</externalid>
        <name>EIF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315009</externalid>
        <name>EIF3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314985</externalid>
        <name>EIF3I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315089</externalid>
        <name>EIF4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3T0F4</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72649</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72662</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72702</externalid>
    <name>Ribosomal scanning and start codon recognition</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72702</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>RPS5</name>
        <entity>
          <protein>
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              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315025</externalid>
        <name>EIF3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314877</externalid>
        <name>RPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314957</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314993</externalid>
        <name>EIF3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315013</externalid>
        <name>EIF3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314891</externalid>
        <name>RPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315075</externalid>
        <name>EIF4E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NEI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315005</externalid>
        <name>EIF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315001</externalid>
        <name>EIF3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315033</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315029</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315095</externalid>
        <name>EIF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315021</externalid>
        <name>EIF3K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315041</externalid>
        <name>EIF1AX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314989</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314981</externalid>
        <name>EIF3J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314997</externalid>
        <name>EIF3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315085</externalid>
        <name>EIF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315009</externalid>
        <name>EIF3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T122</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314985</externalid>
        <name>EIF3I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315089</externalid>
        <name>EIF4H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72702</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72706</externalid>
    <name>GTP hydrolysis and joining of the 60S ribosomal subunit</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72706</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
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      <gene>
        <externalid>10315183</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS17</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPL15</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
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              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314835</externalid>
        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314851</externalid>
        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315411</externalid>
        <name>RPL36A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315281</externalid>
        <name>RPL29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315343</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314843</externalid>
        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315265</externalid>
        <name>RPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q862I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315299</externalid>
        <name>RPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314929</externalid>
        <name>RPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315383</externalid>
        <name>RPL26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315319</externalid>
        <name>RPL38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315159</externalid>
        <name>RPL10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315225</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315209</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315397</externalid>
        <name>RPL3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315335</externalid>
        <name>RPL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315315</externalid>
        <name>RPL37A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MIC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315403</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315243</externalid>
        <name>RPL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315307</externalid>
        <name>RPL36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T171</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315187</externalid>
        <name>LOC101903301</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N288</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315175</externalid>
        <name>RPL13A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315205</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315435</externalid>
        <name>EIF5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6Y7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315303</externalid>
        <name>RPL35A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JY1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314877</externalid>
        <name>RPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314957</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315251</externalid>
        <name>RPL23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T057</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315235</externalid>
        <name>RPL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315285</externalid>
        <name>RPL30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0D5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314891</externalid>
        <name>RPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315393</externalid>
        <name>RPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315255</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315339</externalid>
        <name>RPL7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315347</externalid>
        <name>RPL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0S6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315163</externalid>
        <name>RPL11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315239</externalid>
        <name>RPL18A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T003</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315213</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315371</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDD7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315361</externalid>
        <name>RPL10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSI3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315387</externalid>
        <name>RPL26L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315147</externalid>
        <name>RPLP0</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDN4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315407</externalid>
        <name>LOC101906221</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL02</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315197</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGH0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL28</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ34</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPL14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>RPL13</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MK30</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315155</externalid>
        <name>RPLP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T051</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10315167</externalid>
        <name>RPL12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61284</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJL1</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315323</externalid>
        <name>RPL4</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
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          </protein>
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      <gene>
        <externalid>10314905</externalid>
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        <entity>
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      <gene>
        <externalid>10315217</externalid>
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              <externalid>F1N0W3</externalid>
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      <gene>
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      <gene>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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              <externalid>P63048</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315229</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
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          </protein>
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      <gene>
        <externalid>10314855</externalid>
        <entity>
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              <externalid>A0A3Q1MBL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
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          <protein>
            <xref>
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              <externalid>P62276</externalid>
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          </protein>
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      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
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            <xref>
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              <externalid>P79244</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
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              <externalid>Q56JX8</externalid>
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          </protein>
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      <gene>
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        <name>RPL5</name>
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          </protein>
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      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
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              <externalid>P61356</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
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          <protein>
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              <externalid>Q3T0F4</externalid>
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          </protein>
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    </genes>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
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          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72706</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72731</externalid>
    <name>Recycling of eIF2:GDP</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72731</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10315129</externalid>
        <name>EIF2B4</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1LPP5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315053</externalid>
        <name>EIF2S3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315049</externalid>
        <name>EIF2S2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQI5</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315125</externalid>
        <name>EIF2B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315121</externalid>
        <name>EIF2B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315133</externalid>
        <name>EIF2B5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315137</externalid>
        <name>EIF2B3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72731</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72737</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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    <externalid>R-BTA-156827</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10315393</externalid>
        <name>RPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P39872</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315255</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314831</externalid>
        <name>RPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315339</externalid>
        <name>RPL7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315079</externalid>
        <name>EIF4G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315001</externalid>
        <name>EIF3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315347</externalid>
        <name>RPL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315163</externalid>
        <name>RPL11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315033</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315239</externalid>
        <name>RPL18A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T003</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315029</externalid>
        <name>EIF3M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314863</externalid>
        <name>RPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315045</externalid>
        <name>EIF2S1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315213</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315371</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N267</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315361</externalid>
        <name>RPL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315387</externalid>
        <name>RPL26L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314859</externalid>
        <name>RPS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315021</externalid>
        <name>EIF3K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315147</externalid>
        <name>RPLP0</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315407</externalid>
        <name>LOC101906221</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315067</externalid>
        <name>EIF4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314989</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315197</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MGH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315277</externalid>
        <name>RPL28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314885</externalid>
        <name>RPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321611</externalid>
        <name>PABPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61286</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315179</externalid>
        <name>RPL14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315171</externalid>
        <name>RPL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK30</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315155</externalid>
        <name>RPLP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P42899</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315427</externalid>
        <name>RPL39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T051</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315167</externalid>
        <name>RPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61284</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315017</externalid>
        <name>EIF3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T102</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315201</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315323</externalid>
        <name>RPL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314905</externalid>
        <name>RPS3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315217</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314939</externalid>
        <name>RPS27L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315229</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315331</externalid>
        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-156827</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72613</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1799339</externalid>
    <name>SRP-dependent cotranslational protein targeting to membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1799339</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314839</externalid>
        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315191</externalid>
        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314917</externalid>
        <name>RPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H769</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315229</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7T9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314855</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314895</externalid>
        <name>RPS29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62276</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315311</externalid>
        <name>RPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79244</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314823</externalid>
        <name>RPS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
        <externalid>R-HSA-1799339</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156842</externalid>
    <name>Eukaryotic Translation Elongation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10321644</externalid>
        <name>EEF1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG05</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321659</externalid>
        <name>EEF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321640</externalid>
        <name>EEF1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321630</externalid>
        <name>EEF1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68103</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-156902</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-156842</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-156902</externalid>
    <name>Peptide chain elongation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-156902</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
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        <name>EEF2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU2</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-156902</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-156842</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-72764</externalid>
    <name>Eukaryotic Translation Termination</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-72764</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10393794</externalid>
        <name>N6AMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R0T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348908</externalid>
        <name>GSPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MH45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393798</externalid>
        <name>TRMT112</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386957</externalid>
        <name>APEH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348900</externalid>
        <name>ETF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX5</externalid>
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          </protein>
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      <gene>
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        <name>GSPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q087</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5691515</externalid>
        <name>N-terminal N-acetyl-L-serine residue</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>83690</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1667008</externalid>
        <name>protein</name>
        <xref>
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          <externalid>36080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-72764</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Mitochondrial translation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5368287</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>MRPL57</name>
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              <externalid>Q3ZC04</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10322771</externalid>
        <name>MT-ND6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03924</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245923</externalid>
        <name>MRPL16</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245914</externalid>
        <name>MRPL13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378750</externalid>
        <name>OXA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246000</externalid>
        <name>MRPL48</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378555</externalid>
        <name>MRPS34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378681</externalid>
        <name>MRPL39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M488</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99454</externalid>
        <name>MRPS18C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82917</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378530</externalid>
        <name>MRPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420000</externalid>
        <name>MALSU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P562</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322635</externalid>
        <name>COX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244211</externalid>
        <name>PTCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378692</externalid>
        <name>MRPL41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJ71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322767</externalid>
        <name>ND5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q85BD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100850</externalid>
        <name>MRPS30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82924</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245893</externalid>
        <name>MRPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378704</externalid>
        <name>MRPL45</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378589</externalid>
        <name>DAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378499</externalid>
        <name>MRPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N498</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378657</externalid>
        <name>MRPL28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378662</externalid>
        <name>MRPL30</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T852</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL4</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385976</externalid>
        <name>MRPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8NN94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378540</externalid>
        <name>MRPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378522</externalid>
        <name>MRPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7M3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378572</externalid>
        <name>MRPS18B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N059</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100797</externalid>
        <name>MRPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82931</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322623</externalid>
        <name>COX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246667</externalid>
        <name>MRPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T040</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378630</externalid>
        <name>MRPL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMM8</externalid>
            </xref>
          </protein>
        </entity>
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              <externalid>Q2TBI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245956</externalid>
        <name>MRPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5389840</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5419276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9937383</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5368287</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5389840</externalid>
    <name>Mitochondrial translation elongation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5389840</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>246018</externalid>
        <name>MRPL53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246716</externalid>
        <name>MRPL57</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100855</externalid>
        <name>MRPL42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82927</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378716</externalid>
        <name>MRPL49</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378518</externalid>
        <name>MRPS22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153361</externalid>
        <name>MRPS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6B860</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245900</externalid>
        <name>MRPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245923</externalid>
        <name>MRPL16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245914</externalid>
        <name>MRPL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245913</externalid>
        <name>MRPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YR75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246702</externalid>
        <name>MRPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378750</externalid>
        <name>OXA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246000</externalid>
        <name>MRPL48</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378729</externalid>
        <name>MRPL54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N148</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378555</externalid>
        <name>MRPS34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378681</externalid>
        <name>MRPL39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M488</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99454</externalid>
        <name>MRPS18C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82917</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245977</externalid>
        <name>MRPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100844</externalid>
        <name>MRPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82928</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244211</externalid>
        <name>PTCD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378692</externalid>
        <name>MRPL41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJ71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245997</externalid>
        <name>MRPL46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100850</externalid>
        <name>MRPS30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82924</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245893</externalid>
        <name>MRPL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378601</externalid>
        <name>ERAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378704</externalid>
        <name>MRPL45</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378568</externalid>
        <name>MRPS18A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378589</externalid>
        <name>DAP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378499</externalid>
        <name>MRPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N498</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378740</externalid>
        <name>GADD45GIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245928</externalid>
        <name>MRPL17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>525944</externalid>
        <name>MRPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378657</externalid>
        <name>MRPL28</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378662</externalid>
        <name>MRPL30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T852</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245919</externalid>
        <name>MRPL15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245895</externalid>
        <name>MRPL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS27</name>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS23</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL52</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378711</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <externalid>F1N059</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378675</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS10</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P82670</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378585</externalid>
        <name>CHCHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS33</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82669</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246667</externalid>
        <name>MRPS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T040</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL19</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MMM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS12</name>
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          <protein>
            <xref>
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              <externalid>Q29RU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL44</name>
        <entity>
          <protein>
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              <externalid>A0A452DIH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246008</externalid>
        <name>MRPL51</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P0C2B6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100814</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P82908</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>MRPL20</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL40</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N1R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL58</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T116</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL55</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL27</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246665</externalid>
        <name>MRPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>MRPS9</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58DQ5</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>MRPS15</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPL21</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MSV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MRPS17</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-5389840</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5368287</externalid>
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    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5419276</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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        <name>OXA1L</name>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>PTCD3</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
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          </protein>
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          </protein>
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          </protein>
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              <externalid>Q3MHI7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>GFM2</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323117</externalid>
        <name>MT-CYB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00157</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246018</externalid>
        <name>MRPL53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100855</externalid>
        <name>MRPL42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82927</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322629</externalid>
        <name>MT-CO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68530</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378716</externalid>
        <name>MRPL49</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378518</externalid>
        <name>MRPS22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153361</externalid>
        <name>MRPS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6B860</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245900</externalid>
        <name>MRPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323166</externalid>
        <name>MT-ATP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378807</externalid>
        <name>MRRF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245913</externalid>
        <name>MRPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YR75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246702</externalid>
        <name>MRPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378729</externalid>
        <name>MRPL54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N148</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245977</externalid>
        <name>MRPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100844</externalid>
        <name>MRPS28</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82928</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322789</externalid>
        <name>MT-ND3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245997</externalid>
        <name>MRPL46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378601</externalid>
        <name>ERAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378568</externalid>
        <name>MRPS18A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378740</externalid>
        <name>GADD45GIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245928</externalid>
        <name>MRPL17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>525944</externalid>
        <name>MRPL37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322779</externalid>
        <name>ND2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245919</externalid>
        <name>MRPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378724</externalid>
        <name>MRPL52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378711</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNT0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100828</externalid>
        <name>MRPS21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82920</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378675</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100804</externalid>
        <name>MRPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82670</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245904</externalid>
        <name>MRPL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHY7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378585</externalid>
        <name>CHCHD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100857</externalid>
        <name>MRPS33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82926</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100838</externalid>
        <name>MRPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82669</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378700</externalid>
        <name>MRPL44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246008</externalid>
        <name>MRPL51</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C2B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322763</externalid>
        <name>MT-ND4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03910</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153073</externalid>
        <name>MRPL43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245933</externalid>
        <name>MRPL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378581</externalid>
        <name>AURKAIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378550</externalid>
        <name>MRPS31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100788</externalid>
        <name>MRPS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82923</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378793</externalid>
        <name>MT-ND4L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03902</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153365</externalid>
        <name>KGD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82908</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378733</externalid>
        <name>MRPL55</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246665</externalid>
        <name>MRPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323186</externalid>
        <name>MT-ATP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03929</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378507</externalid>
        <name>MRPS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A5H1ZRH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245982</externalid>
        <name>MRPL38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378641</externalid>
        <name>MRPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100818</externalid>
        <name>MRPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82916</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246005</externalid>
        <name>MRPL50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246707</externalid>
        <name>MRPS35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245971</externalid>
        <name>MRPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245956</externalid>
        <name>MRPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5419276</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5368287</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9937383</externalid>
    <name>Mitochondrial ribosome-associated quality control</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9937383</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>246018</externalid>
        <name>MRPL53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246716</externalid>
        <name>MRPL57</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>100855</externalid>
        <name>MRPL42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82927</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378716</externalid>
        <name>MRPL49</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378518</externalid>
        <name>MRPS22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>153361</externalid>
        <name>MRPS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6B860</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245900</externalid>
        <name>MRPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245923</externalid>
        <name>MRPL16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0J3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245914</externalid>
        <name>MRPL13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245913</externalid>
        <name>MRPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YR75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246702</externalid>
        <name>MRPS26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378750</externalid>
        <name>OXA1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>246000</externalid>
        <name>MRPL48</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378729</externalid>
        <name>MRPL54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N148</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378555</externalid>
        <name>MRPS34</name>
        <entity>
          <protein>
            <xref>
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      <linkedsystem>
        <externalid>R-HSA-9937383</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5368287</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9948299</externalid>
    <name>Ribosome-associated quality control</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9948299</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>ZNF598</name>
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              <externalid>A0A3Q1LWW3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPL10L</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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        <name>UBC</name>
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          </protein>
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      <gene>
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        <name>RPL15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMD3</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <entity>
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            </xref>
          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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            </xref>
          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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            </xref>
          </protein>
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      <gene>
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        <entity>
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            </xref>
          </protein>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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          <protein>
            <xref>
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            </xref>
          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
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        <name>UBB</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
        </entity>
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          </protein>
        </entity>
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          </protein>
        </entity>
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        <externalid>10376992</externalid>
        <name>ABCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315331</externalid>
        <name>RPL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315269</externalid>
        <name>RPL27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314811</externalid>
        <name>RPS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9954716</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9954714</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9954709</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9948299</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-72766</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9954716</externalid>
    <name>ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9954716</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10420395</externalid>
        <name>ZNF598</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315351</externalid>
        <name>RPL9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315183</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314909</externalid>
        <name>RPS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E988</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314921</externalid>
        <name>RPS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E958</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315365</externalid>
        <name>RPL10L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315295</externalid>
        <name>RPL34</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314925</externalid>
        <name>RPS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315291</externalid>
        <name>RPL32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314847</externalid>
        <name>RPS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315259</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BII3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315375</externalid>
        <name>RPL22L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314945</externalid>
        <name>RPS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315151</externalid>
        <name>RPLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314899</externalid>
        <name>RPS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T169</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315247</externalid>
        <name>RPL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q861S4</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>RPS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T832</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314881</externalid>
        <name>RPS25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314949</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X6</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>ascc3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS15A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I82</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>RPL29</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>RPS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0R1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPL24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q862I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM7</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>RPSA</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>RPL26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61257</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315159</externalid>
        <name>RPL10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E6</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10315225</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315209</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPL3L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315335</externalid>
        <name>RPL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315315</externalid>
        <name>RPL37A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MIC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314935</externalid>
        <name>RPS27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315403</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315243</externalid>
        <name>RPL19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315307</externalid>
        <name>RPL36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T171</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315187</externalid>
        <name>LOC101903301</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314827</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MR01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314819</externalid>
        <name>RPS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76I81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315221</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N288</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315175</externalid>
        <name>RPL13A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ90</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314961</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314953</externalid>
        <name>RPS4Y1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314815</externalid>
        <name>RPS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315205</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315303</externalid>
        <name>RPL35A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314877</externalid>
        <name>RPS24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314957</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315251</externalid>
        <name>RPL23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T057</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315235</externalid>
        <name>RPL18</name>
        <entity>
          <protein>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339635</externalid>
        <name>CCT6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368842</externalid>
        <name>RGS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398790</externalid>
        <name>RGS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46470</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398800</externalid>
        <name>RGS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-390466</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-391251</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390466</externalid>
    <name>Chaperonin-mediated protein folding</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390466</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339623</externalid>
        <name>CCT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339619</externalid>
        <name>CCT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91028</externalid>
        <name>GNA14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339603</externalid>
        <name>TCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E531</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319764</externalid>
        <name>GNG11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319756</externalid>
        <name>GNGT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P50154</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339615</externalid>
        <name>CCT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91082</externalid>
        <name>GNG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63212</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68399</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319784</externalid>
        <name>GNB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397548</externalid>
        <name>PDCL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319464</externalid>
        <name>GNAQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398796</externalid>
        <name>RGS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFC7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9729199</externalid>
        <name>GNB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339627</externalid>
        <name>CCT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339607</externalid>
        <name>CCT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55402</externalid>
        <name>GNG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63214</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319792</externalid>
        <name>GNB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74067</externalid>
        <name>GNGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02698</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339611</externalid>
        <name>CCT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319740</externalid>
        <name>GNG4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFL6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319744</externalid>
        <name>GNG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319752</externalid>
        <name>GNG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339631</externalid>
        <name>CCT6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339635</externalid>
        <name>CCT6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368842</externalid>
        <name>RGS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398790</externalid>
        <name>RGS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46470</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319768</externalid>
        <name>GNG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319748</externalid>
        <name>GNG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398800</externalid>
        <name>RGS11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>91022</externalid>
        <name>GNA11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P38409</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319760</externalid>
        <name>GNG10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-390471</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6814122</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-390466</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391251</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390471</externalid>
    <name>Association of TriC/CCT with target proteins during biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-390471</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339623</externalid>
        <name>CCT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339619</externalid>
        <name>CCT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339631</externalid>
        <name>CCT6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339603</externalid>
        <name>TCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E531</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339599</externalid>
        <name>SPHK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339635</externalid>
        <name>CCT6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339627</externalid>
        <name>CCT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339607</externalid>
        <name>CCT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339611</externalid>
        <name>CCT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339615</externalid>
        <name>CCT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-390471</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-390466</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6814122</externalid>
    <name>Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6814122</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339623</externalid>
        <name>CCT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCT7</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2NKZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GNA14</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      <gene>
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        <name>TCP1</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>GNG11</name>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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            </xref>
          </protein>
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      <gene>
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        <name>CCT5</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330746</externalid>
        <name>CSNK2A1</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>GNB2</name>
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          </protein>
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      <gene>
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        <name>PDCL</name>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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        <name>CFP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340542</externalid>
        <name>ARRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X811</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404388</externalid>
        <name>TECTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331905</externalid>
        <name>STX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332217</externalid>
        <name>EIF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6EWQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348492</externalid>
        <name>GCNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386792</externalid>
        <name>GPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339682</externalid>
        <name>SPTA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347778</externalid>
        <name>CP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N076</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398830</externalid>
        <name>NGLY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031635</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449253</externalid>
        <name>glycan G10595</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549017</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549011</externalid>
        <name>N-{alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29866</externalid>
        <name>N-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8980584</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53058</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549023</externalid>
        <name>N-{alpha-Glc-(1-&gt;2)-alpha-Glc-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc} group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332985</externalid>
        <name>(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114825</externalid>
        <name>2-trans,6-trans,10-trans-geranylgeranyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>48861</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36219</externalid>
        <name>diacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549013</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549012</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549010</externalid>
        <name>alpha-Gal-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162846</externalid>
        <name>acylglucosaminylphosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549019</externalid>
        <name>alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-D-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788888</externalid>
        <name>psicosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87176</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940812</externalid>
        <name>D-ribitol 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57695</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788892</externalid>
        <name>ribulosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87177</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788887</externalid>
        <name>psicosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87179</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940862</externalid>
        <name>CDP-ribitol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855698</externalid>
        <name>proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861836</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788757</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine methyl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37949</externalid>
        <name>(alpha-D-mannosyl)4-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31055</externalid>
        <name>trimethylenediamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767878</externalid>
        <name>6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449634</externalid>
        <name>glycan G10599</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332984</externalid>
        <name>bicyclo[3.3.0]oct-2-ene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861833</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449308</externalid>
        <name>N-acetyl-D-glucosaminyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861835</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91283</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17650</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788891</externalid>
        <name>ribulosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>39257</externalid>
        <name>rifampicin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28077</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37945</externalid>
        <name>beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162782</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162763</externalid>
        <name>6-O-[alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767880</externalid>
        <name>6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57265</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788766</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163125</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446203</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5173105</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2990846</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-5688426</externalid>
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          <subset />
        </linkedsystemtype>
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      <linkedsystem>
        <externalid>R-BTA-8852135</externalid>
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          <subset />
        </linkedsystemtype>
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      <linkedsystem>
        <externalid>R-BTA-9907900</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8873719</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8876725</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8951664</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8957275</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
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      <linkedsystem>
        <externalid>R-BTA-9857492</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-597592</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163841</externalid>
    <name>Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163841</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>G3N1V4</externalid>
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        <name>BGLAP</name>
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              <externalid>A1A4R0</externalid>
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        <name>EEF2</name>
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              <externalid>Q3SYU2</externalid>
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        <name>JMJD6</name>
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              <externalid>A0A452DJR2</externalid>
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      <gene>
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        <name>TPST2</name>
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              <externalid>Q3SYY2</externalid>
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      <gene>
        <externalid>10378195</externalid>
        <name>DPH2</name>
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              <externalid>A0A140T8A2</externalid>
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              <externalid>A0A3Q1LGQ6</externalid>
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              <externalid>G3N2T7</externalid>
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              <externalid>Q58CP2</externalid>
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              <externalid>F1MZ40</externalid>
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              <externalid>Q1RMM1</externalid>
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              <externalid>E1BKH3</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>RPS23</name>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>DPH3</name>
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              <externalid>Q1LZC9</externalid>
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          </protein>
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      <gene>
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        <name>FURIN</name>
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              <externalid>B0JYR0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPL8</name>
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              <externalid>Q3T0S6</externalid>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>TPST1</name>
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              <externalid>Q08DH2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DNAJC24</name>
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      <gene>
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        <name>ARSA</name>
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          </protein>
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      <gene>
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        <name>OGFOD1</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>GGCX</name>
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      <gene>
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        <name>RIOX2</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>F7</name>
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      <gene>
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      <gene>
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        <name>F7</name>
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      <gene>
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        <name>DOHH</name>
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      <gene>
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      <gene>
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        <name>F9</name>
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              <externalid>F1MBC5</externalid>
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      <gene>
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        <name>DPH5</name>
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          </protein>
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      <gene>
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        <name>JMJD7</name>
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          <protein>
            <xref>
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              <externalid>F1MEH3</externalid>
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          </protein>
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      <gene>
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        <name>ETF1</name>
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          <protein>
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              <externalid>Q0VCX5</externalid>
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      <gene>
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        <name>ARSE</name>
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              <externalid>A5D7J7</externalid>
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          </protein>
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      <gene>
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        <name>STS</name>
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          <protein>
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              <externalid>A0A3Q1LZ44</externalid>
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          </protein>
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      <gene>
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        <name>RPS6</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
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          </protein>
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      <gene>
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        <name>RPL27A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SUMF1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L5</externalid>
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          </protein>
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      <gene>
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        <name>FN3KRP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>A0A3Q1M8B7</externalid>
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      <gene>
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        <name>KDM8</name>
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          <protein>
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              <externalid>Q1JP61</externalid>
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      <gene>
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        <name>EIF5A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q6EWQ7</externalid>
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          </protein>
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      <gene>
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        <name>DHPS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6EWQ6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RIOX1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK74</externalid>
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          </protein>
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      <gene>
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        <name>RWDD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC53</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN49</externalid>
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          </protein>
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        <name>ribulosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87177</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>6788887</externalid>
        <name>psicosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87179</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788891</externalid>
        <name>ribulosamine 3-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87180</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788757</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine methyl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31055</externalid>
        <name>trimethylenediamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788888</externalid>
        <name>psicosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87176</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788766</externalid>
        <name>S-[(2E,6E)-farnesyl]-L-cysteine residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86019</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-159854</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-204626</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5358493</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1663150</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9629569</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-163841</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159854</externalid>
    <name>Gamma-carboxylation, transport, and amino-terminal cleavage of proteins</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159854</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323028</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07224</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395517</externalid>
        <name>BGLAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323051</externalid>
        <name>GAS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322187</externalid>
        <name>GGCX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07175</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-159740</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159763</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159782</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-159854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159740</externalid>
    <name>Gamma-carboxylation of protein precursors</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159740</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323028</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07224</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395517</externalid>
        <name>BGLAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322187</externalid>
        <name>GGCX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07175</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806367</externalid>
        <name>menaquinone-4</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6807256</externalid>
        <name>2,3-epoxymenatetrenone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-159740</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159763</externalid>
    <name>Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159763</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323028</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07224</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395517</externalid>
        <name>BGLAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323051</externalid>
        <name>GAS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-159763</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-159782</externalid>
    <name>Removal of aminoterminal propeptides from gamma-carboxylated proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-159782</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323028</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8B7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321041</externalid>
        <name>PROS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07224</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395517</externalid>
        <name>BGLAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323051</externalid>
        <name>GAS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320873</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22457</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320489</externalid>
        <name>F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320799</externalid>
        <name>F7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320739</externalid>
        <name>PROC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M616</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320936</externalid>
        <name>F9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-159782</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-159854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-204626</externalid>
    <name>Hypusine synthesis from eIF5A-lysine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-204626</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10332217</externalid>
        <name>EIF5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6EWQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332235</externalid>
        <name>DHPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6EWQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332254</externalid>
        <name>DOHH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760846</externalid>
        <name>spermidine(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57834</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31055</externalid>
        <name>trimethylenediamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15725</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-204626</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5358493</externalid>
    <name>Synthesis of diphthamide-EEF2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5358493</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10378182</externalid>
        <name>DPH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E982</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378191</externalid>
        <name>DPH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378206</externalid>
        <name>DNAJC24</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MH61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321659</externalid>
        <name>EEF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378199</externalid>
        <name>DPH3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378169</externalid>
        <name>DPH6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378195</externalid>
        <name>DPH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8A2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29678</externalid>
        <name>5'-S-methyl-5'-thioadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17509</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5358493</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1663150</externalid>
    <name>The activation of arylsulfatases</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1663150</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358620</externalid>
        <name>ARSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358604</externalid>
        <name>ARSG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N665</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358608</externalid>
        <name>ARSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2T7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358616</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358579</externalid>
        <name>SUMF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358553</externalid>
        <name>ARSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358612</externalid>
        <name>ARSI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358600</externalid>
        <name>ARSE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358565</externalid>
        <name>STS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358575</externalid>
        <name>SUMF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5L5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358541</externalid>
        <name>ARSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654567</externalid>
        <name>NADH(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57945</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1663150</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9629569</externalid>
    <name>Protein hydroxylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9629569</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314867</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411274</externalid>
        <name>RCCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314871</externalid>
        <name>RPS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T199</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411223</externalid>
        <name>JMJD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348900</externalid>
        <name>ETF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314913</externalid>
        <name>RPS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315273</externalid>
        <name>RPL27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56K03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375507</externalid>
        <name>JMJD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315347</externalid>
        <name>RPL8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0S6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411290</externalid>
        <name>JMJD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N531</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375471</externalid>
        <name>RIOX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411265</externalid>
        <name>KDM8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JP61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411234</externalid>
        <name>DRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411318</externalid>
        <name>OGFOD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MI03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411238</externalid>
        <name>ZC3H15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411344</externalid>
        <name>RIOX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK74</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411212</externalid>
        <name>RWDD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411208</externalid>
        <name>DRG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314604</externalid>
        <name>U2AF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316172</externalid>
        <name>2-oxoglutarate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16810</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114738</externalid>
        <name>carbon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9629523</externalid>
        <name>succinate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30031</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9629569</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163841</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163125</externalid>
    <name>Post-translational modification: synthesis of GPI-anchored proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163125</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10404126</externalid>
        <name>ART3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404272</externalid>
        <name>MSLN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393363</externalid>
        <name>BST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404378</externalid>
        <name>SPACA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404217</externalid>
        <name>LY6H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404467</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404202</externalid>
        <name>LY6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404477</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPH8</externalid>
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        <name>LYPD4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIY1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404227</externalid>
        <name>LYPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404158</externalid>
        <name>CNTN3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404222</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404282</externalid>
        <name>NRN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322400</externalid>
        <name>PIGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404173</externalid>
        <name>CPM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403883</externalid>
        <name>VNN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3U5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404192</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4M1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391752</externalid>
        <name>FOLR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCN9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404287</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LK02</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322393</externalid>
        <name>PIGN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM45</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404388</externalid>
        <name>TECTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404373</externalid>
        <name>RTN4RL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322443</externalid>
        <name>PIGV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Z8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404163</externalid>
        <name>CNTN4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE12</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322373</externalid>
        <name>PIGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5332985</externalid>
        <name>(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767878</externalid>
        <name>6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162782</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162763</externalid>
        <name>6-O-[alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8980584</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53058</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767880</externalid>
        <name>6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57265</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162846</externalid>
        <name>acylglucosaminylphosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-162699</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162710</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162791</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-163125</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-162699</externalid>
    <name>Synthesis of dolichyl-phosphate mannose</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-162699</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
      <gene>
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        <name>DPM3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322322</externalid>
        <name>DPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322318</externalid>
        <name>DPM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C7FFR6</externalid>
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          </protein>
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      </gene>
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      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-162699</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163125</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-162710</externalid>
    <name>Synthesis of glycosylphosphatidylinositol (GPI)</name>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-162710</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>PIGG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322362</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIGA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ81</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322393</externalid>
        <name>PIGN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM45</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10322311</externalid>
        <name>PIGW</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3J6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322350</externalid>
        <name>PIGC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322358</externalid>
        <name>PIGP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PC8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322354</externalid>
        <name>PIGH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIGZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIGV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322322</externalid>
        <name>DPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322373</externalid>
        <name>PIGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322436</externalid>
        <name>PIGL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322400</externalid>
        <name>PIGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>5332985</externalid>
        <name>(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77364</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767878</externalid>
        <name>6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162782</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53059</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162763</externalid>
        <name>6-O-[alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53056</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8980584</externalid>
        <name>6-O-{alpha-D-mannosyl-(1-&gt;6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1-&gt;4)-alpha-D-glucosaminyl}-O-acyl-1-phosphatidyl-1D-myo-inositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53058</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767880</externalid>
        <name>6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57265</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114747</externalid>
        <name>acetic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>162846</externalid>
        <name>acylglucosaminylphosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>52572</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767879</externalid>
        <name>fatty acyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77636</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765555</externalid>
        <name>1-phosphatidyl-1D-myo-inositol(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57880</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-162710</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163125</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-162791</externalid>
    <name>Attachment of GPI anchor to uPAR</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-162791</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>PIGS</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MSF3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10322415</externalid>
        <name>PIGK</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHZ7</externalid>
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          </protein>
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      <gene>
        <externalid>10322024</externalid>
        <name>PLAUR</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q05588</externalid>
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          </protein>
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      <gene>
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        <name>PIGU</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N7F8</externalid>
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              <externalid>F1N4W0</externalid>
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      <gene>
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              <externalid>E1BNQ0</externalid>
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      <gene>
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        <name>GPAA1</name>
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              <externalid>Q3T0N7</externalid>
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          </protein>
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      <smallmolecule>
        <externalid>5332985</externalid>
        <name>(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>2255350</externalid>
        <name>long-chain fatty acid anion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57560</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-162791</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163125</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-446203</externalid>
    <name>Asparagine N-linked glycosylation</name>
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      <organism_specific_biosystem />
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    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ALG5</name>
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              <externalid>F1N540</externalid>
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          </protein>
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      <gene>
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              <externalid>E1BJB1</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3T086</externalid>
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          </protein>
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      <gene>
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      <gene>
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        <name>CHST10</name>
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              <externalid>A0A3Q1M1B8</externalid>
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      <gene>
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        <name>ALG14</name>
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        <name>SEC24B</name>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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        <entity>
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          </protein>
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          </protein>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <externalid>449253</externalid>
        <name>glycan G10595</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>53023</externalid>
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      <smallmolecule>
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        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
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      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549017</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549011</externalid>
        <name>N-{alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29866</externalid>
        <name>N-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549023</externalid>
        <name>N-{alpha-Glc-(1-&gt;2)-alpha-Glc-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc} group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36219</externalid>
        <name>diacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549013</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549012</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549010</externalid>
        <name>alpha-Gal-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549019</externalid>
        <name>alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-D-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855698</externalid>
        <name>proteoglycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861836</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37949</externalid>
        <name>(alpha-D-mannosyl)4-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449634</externalid>
        <name>glycan G10599</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861833</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449308</externalid>
        <name>N-acetyl-D-glucosaminyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861835</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91283</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37945</externalid>
        <name>beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-446193</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-532668</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-948021</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-446203</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446193</externalid>
    <name>Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446193</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344212</externalid>
        <name>ALG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312987</externalid>
        <name>HK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358409</externalid>
        <name>NEU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344219</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374244</externalid>
        <name>ST6GALNAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358432</externalid>
        <name>NEU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6BMK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344142</externalid>
        <name>DOLK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344196</externalid>
        <name>ALG14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MW72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374227</externalid>
        <name>ST8SIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344845</externalid>
        <name>GNPNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322318</externalid>
        <name>DPM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C7FFR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374275</externalid>
        <name>NANP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374231</externalid>
        <name>ST8SIA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344167</externalid>
        <name>PMM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396989</externalid>
        <name>NUDT14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346579</externalid>
        <name>MPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322326</externalid>
        <name>DPM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394665</externalid>
        <name>NAGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394656</externalid>
        <name>RENBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8Y1QZV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344205</externalid>
        <name>ALG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344235</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374289</externalid>
        <name>GNE</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MIL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344121</externalid>
        <name>MPDU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374223</externalid>
        <name>ST8SIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353201</externalid>
        <name>ST8SIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374794</externalid>
        <name>DHDDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374216</externalid>
        <name>NANS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389743</externalid>
        <name>GFUS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358452</externalid>
        <name>NEU3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389729</externalid>
        <name>FPGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344156</externalid>
        <name>DOLPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344116</externalid>
        <name>ALG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QW25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351354</externalid>
        <name>ST6GALNAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322322</externalid>
        <name>DPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389736</externalid>
        <name>FUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344836</externalid>
        <name>GFPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347124</externalid>
        <name>SLC35C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413249</externalid>
        <name>SRD5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344128</externalid>
        <name>ALG8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344109</externalid>
        <name>PGM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344228</externalid>
        <name>ALG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2J7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344192</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8G4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353205</externalid>
        <name>ST8SIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374257</externalid>
        <name>CMAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327427</externalid>
        <name>MVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389752</externalid>
        <name>GMDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374798</externalid>
        <name>NUS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344183</externalid>
        <name>UAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374352</externalid>
        <name>NPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374303</externalid>
        <name>ST6GAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344149</externalid>
        <name>ALG12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344832</externalid>
        <name>GFPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358420</externalid>
        <name>NEU4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344239</externalid>
        <name>GMPPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344135</externalid>
        <name>DPAGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374266</externalid>
        <name>ST3GAL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394674</externalid>
        <name>AMDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344163</externalid>
        <name>PMM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374240</externalid>
        <name>ST6GALNAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6V7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344176</externalid>
        <name>ALG6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QF86</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>449253</externalid>
        <name>glycan G10595</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53023</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549017</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37949</externalid>
        <name>(alpha-D-mannosyl)4-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37633</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449634</externalid>
        <name>glycan G10599</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53020</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449308</externalid>
        <name>N-acetyl-D-glucosaminyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18278</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>36219</externalid>
        <name>diacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18341</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549012</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549013</externalid>
        <name>alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59088</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549010</externalid>
        <name>alpha-Gal-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-alpha-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59081</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549019</externalid>
        <name>alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-D-GlcNAc(PP-Dol)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59085</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37945</externalid>
        <name>beta-D-mannosyldiacetylchitobiosyldiphosphodolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18396</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-446193</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446203</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446219</externalid>
    <name>Synthesis of substrates in N-glycan biosythesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446219</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344212</externalid>
        <name>ALG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312987</externalid>
        <name>HK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358409</externalid>
        <name>NEU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374244</externalid>
        <name>ST6GALNAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358432</externalid>
        <name>NEU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6BMK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344142</externalid>
        <name>DOLK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374227</externalid>
        <name>ST8SIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344845</externalid>
        <name>GNPNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322318</externalid>
        <name>DPM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C7FFR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374275</externalid>
        <name>NANP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374231</externalid>
        <name>ST8SIA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344167</externalid>
        <name>PMM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396989</externalid>
        <name>NUDT14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346579</externalid>
        <name>MPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322326</externalid>
        <name>DPM3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3ZC71</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394665</externalid>
        <name>NAGK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJF8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394656</externalid>
        <name>RENBP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8Y1QZV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344235</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374289</externalid>
        <name>GNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374223</externalid>
        <name>ST8SIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353201</externalid>
        <name>ST8SIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374794</externalid>
        <name>DHDDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374216</externalid>
        <name>NANS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389743</externalid>
        <name>GFUS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358452</externalid>
        <name>NEU3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRJ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1P7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389729</externalid>
        <name>FPGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344156</externalid>
        <name>DOLPP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW49</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351354</externalid>
        <name>ST6GALNAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322322</externalid>
        <name>DPM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYZ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389736</externalid>
        <name>FUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344836</externalid>
        <name>GFPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347124</externalid>
        <name>SLC35C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM03</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413249</externalid>
        <name>SRD5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344109</externalid>
        <name>PGM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353205</externalid>
        <name>ST8SIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374257</externalid>
        <name>CMAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327427</externalid>
        <name>MVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389752</externalid>
        <name>GMDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBY8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374798</externalid>
        <name>NUS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344183</externalid>
        <name>UAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374352</externalid>
        <name>NPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RY9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374303</externalid>
        <name>ST6GAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344832</externalid>
        <name>GFPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZY2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358420</externalid>
        <name>NEU4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344239</externalid>
        <name>GMPPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374266</externalid>
        <name>ST3GAL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394674</externalid>
        <name>AMDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344163</externalid>
        <name>PMM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC17</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374240</externalid>
        <name>ST6GALNAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6V7</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767870</externalid>
        <name>dolichyl D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-446199</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446210</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446205</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-162699</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-480985</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-4085001</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6787639</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-446219</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446193</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446199</externalid>
    <name>Synthesis of dolichyl-phosphate</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446199</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10374794</externalid>
        <name>DHDDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RWD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374798</externalid>
        <name>NUS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAW4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10413249</externalid>
        <name>SRD5A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344142</externalid>
        <name>DOLK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344156</externalid>
        <name>DOLPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327427</externalid>
        <name>MVD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P570</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9937301</externalid>
        <name>di-trans,poly-cis-dolichal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854160</externalid>
        <name>2-trans,6-trans-farnesyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>175763</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30058</externalid>
        <name>dolichol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16091</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937343</externalid>
        <name>dolichyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57497</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937299</externalid>
        <name>ditrans,polycis-polyprenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>136960</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937310</externalid>
        <name>di-trans,poly-cis-polyprenal</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>231623</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9937306</externalid>
        <name>(R)-5-diphosphonatomevalonate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29600</externalid>
        <name>isopentenyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>128769</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-446199</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446210</externalid>
    <name>Synthesis of UDP-N-acetyl-glucosamine</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446210</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344836</externalid>
        <name>GFPT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394665</externalid>
        <name>NAGK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394656</externalid>
        <name>RENBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A8Y1QZV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344832</externalid>
        <name>GFPT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344183</externalid>
        <name>UAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344109</externalid>
        <name>PGM3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344845</externalid>
        <name>GNPNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394674</externalid>
        <name>AMDHD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6803731</externalid>
        <name>N-glycoloyl-D-glucosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>88130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933524</externalid>
        <name>alpha-D-glucosamine 6-phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75989</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760813</externalid>
        <name>cholate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29747</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34235</externalid>
        <name>N-glycoloyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27459</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772356</externalid>
        <name>N-acetyl-alpha-D-glucosamine 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57776</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9772357</externalid>
        <name>N-acetyl-D-glucosamine 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57513</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-446210</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446205</externalid>
    <name>Synthesis of GDP-mannose</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446205</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312987</externalid>
        <name>HK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPF0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346579</externalid>
        <name>MPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344235</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344239</externalid>
        <name>GMPPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344167</externalid>
        <name>PMM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344163</externalid>
        <name>PMM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909232</externalid>
        <name>alpha-D-mannose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58409</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9909173</externalid>
        <name>D-mannopyranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58735</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-446205</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-480985</externalid>
    <name>Synthesis of dolichyl-phosphate-glucose</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-480985</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344212</externalid>
        <name>ALG5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N540</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396989</externalid>
        <name>NUDT14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736392</externalid>
        <name>uridine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57865</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31487</externalid>
        <name>dolichyl beta-D-glucosyl phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912874</externalid>
        <name>alpha-D-glucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58601</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-480985</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-4085001</externalid>
    <name>Sialic acid metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-4085001</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10358409</externalid>
        <name>NEU2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374244</externalid>
        <name>ST6GALNAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358432</externalid>
        <name>NEU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6BMK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374227</externalid>
        <name>ST8SIA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353205</externalid>
        <name>ST8SIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374257</externalid>
        <name>CMAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374275</externalid>
        <name>NANP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374231</externalid>
        <name>ST8SIA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374248</externalid>
        <name>ST6GALNAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374352</externalid>
        <name>NPL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374303</externalid>
        <name>ST6GAL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374289</externalid>
        <name>GNE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342304</externalid>
        <name>SLC17A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7R3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358420</externalid>
        <name>NEU4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374223</externalid>
        <name>ST8SIA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353201</externalid>
        <name>ST8SIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374266</externalid>
        <name>ST3GAL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374216</externalid>
        <name>NANS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358424</externalid>
        <name>CTSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358452</externalid>
        <name>NEU3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364385</externalid>
        <name>ST3GAL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358370</externalid>
        <name>GLB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NDQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351354</externalid>
        <name>ST6GALNAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374240</externalid>
        <name>ST6GALNAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6V7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316212</externalid>
        <name>phosphonatoenolpyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58702</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38517</externalid>
        <name>N-acetylneuraminic acid 9-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27438</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086315</externalid>
        <name>N-acetyl-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21507</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9842003</externalid>
        <name>N-acetylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35418</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840627</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-[beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82639</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840596</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87792</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088008</externalid>
        <name>N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75133</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34581</externalid>
        <name>N-glycoloylneuraminate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29025</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316164</externalid>
        <name>pyruvate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15361</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840595</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(d18:1)(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78455</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086310</externalid>
        <name>alpha-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61248</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35809</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine 6-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845513</externalid>
        <name>beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>87785</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4087974</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;3)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75127</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840592</externalid>
        <name>alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78447</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4086326</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30509</externalid>
        <name>aldehydo-N-acetyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17122</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34747</externalid>
        <name>N-glycolyl-D-mannosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28255</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9845554</externalid>
        <name>alpha-Neu5Ac-(2-&gt;3)-beta-Gal-(1-&gt;3)-beta-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;8)-alpha-Neu5Ac-(2-&gt;3)]-beta-Gal-(1-&gt;4)-beta-Glc-(1&lt;-&gt;1')-Cer(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78452</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088009</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;8)-alpha-N-acetylneuraminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75130</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>4088002</externalid>
        <name>alpha-N-acetylneuraminyl-(2-&gt;6)-D-galactosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>75129</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9840591</externalid>
        <name>alpha-N-acetylneuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-[alpha-N-acetylneuraminosyl-(2-&gt;3)]-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-ceramide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4085001</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6787639</externalid>
    <name>GDP-fucose biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6787639</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10389752</externalid>
        <name>GMDS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347124</externalid>
        <name>SLC35C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QM03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389743</externalid>
        <name>GFUS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1P7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389729</externalid>
        <name>FPGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389736</externalid>
        <name>FUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787695</externalid>
        <name>beta-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42589</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767522</externalid>
        <name>GDP-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57527</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970955</externalid>
        <name>GDP-4-dehydro-beta-L-fucose(2−)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>746915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970538</externalid>
        <name>beta-L-fucose 1-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57268</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6787694</externalid>
        <name>alpha-L-fucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42548</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9970531</externalid>
        <name>GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57964</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6787639</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446219</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-532668</externalid>
    <name>N-glycan trimming in the ER and Calnexin/Calreticulin cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-532668</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10346604</externalid>
        <name>CALR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398822</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385419</externalid>
        <name>RAD23B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398826</externalid>
        <name>DERL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q71SS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346600</externalid>
        <name>canx</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398830</externalid>
        <name>NGLY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399526</externalid>
        <name>ENGASE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398834</externalid>
        <name>UBXN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346668</externalid>
        <name>PDIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8861836</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861830</externalid>
        <name>alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91280</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861837</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91284</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861833</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91281</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8861835</externalid>
        <name>alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>91283</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-901042</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-532668</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446203</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-901042</externalid>
    <name>Calnexin/calreticulin cycle</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-901042</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346604</externalid>
        <name>CALR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346600</externalid>
        <name>canx</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z066</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346668</externalid>
        <name>PDIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-901032</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-901042</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-532668</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-901032</externalid>
    <name>ER Quality Control Compartment (ERQC)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-901032</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>UBC</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
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      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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    </genes>
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        <externalid>1031638</externalid>
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          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-901032</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
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        <externalid>R-BTA-901042</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    <name>Transport to the Golgi and subsequent modification</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-948021</url>
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      <gene>
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        <name>CHST10</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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        <name>NAPG</name>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
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    </genes>
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      <smallmolecule>
        <externalid>1031635</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29866</externalid>
        <name>N-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549011</externalid>
        <name>N-{alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549023</externalid>
        <name>N-{alpha-Glc-(1-&gt;2)-alpha-Glc-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc} group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-199977</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-964739</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975576</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-948021</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446203</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-964739</externalid>
    <name>N-glycan trimming and elongation in the cis-Golgi</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-964739</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349411</externalid>
        <name>MAN1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349435</externalid>
        <name>MGAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349428</externalid>
        <name>MANEA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349419</externalid>
        <name>MAN1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7B0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349415</externalid>
        <name>MAN1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>549011</externalid>
        <name>N-{alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;4)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59089</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549023</externalid>
        <name>N-{alpha-Glc-(1-&gt;2)-alpha-Glc-(1-&gt;3)-alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc} group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59084</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-964827</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-964739</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-948021</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-964827</externalid>
    <name>Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-964827</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349411</externalid>
        <name>MAN1A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349419</externalid>
        <name>MAN1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7B0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349415</externalid>
        <name>MAN1A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031638</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60629</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031639</externalid>
        <name>N(4)-{alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;3)-[alpha-D-Manp-(1-&gt;2)-alpha-D-Manp-(1-&gt;6)]-alpha-D-Manp-(1-&gt;6)]-beta-D-Manp-(1-&gt;4)-beta-D-GlcpNAc-(1-&gt;4)-beta-D-GlcpNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60628</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031637</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60627</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031640</externalid>
        <name>N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60637</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549018</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;6)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)]-alpha-Man-(1-&gt;3)]-beta-Man-(1-&gt;4)-beta-GlcnAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59092</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549020</externalid>
        <name>N-{alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNac}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59087</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-964827</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-964739</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975576</externalid>
    <name>N-glycan antennae elongation in the medial/trans-Golgi</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975576</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10350900</externalid>
        <name>MGAT4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77836</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389539</externalid>
        <name>CHST10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353205</externalid>
        <name>ST8SIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350917</externalid>
        <name>MGAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350875</externalid>
        <name>MAN2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387369</externalid>
        <name>FUCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LIN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350967</externalid>
        <name>MGAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350886</externalid>
        <name>MGAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350904</externalid>
        <name>MGAT4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350869</externalid>
        <name>MAN2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7T2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350944</externalid>
        <name>B4GALT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RH18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389532</externalid>
        <name>CHST8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C0LMH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353201</externalid>
        <name>ST8SIA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350932</externalid>
        <name>B4GALT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353214</externalid>
        <name>FUT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350908</externalid>
        <name>MGAT4C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387378</externalid>
        <name>FUT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1031635</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29866</externalid>
        <name>N-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17012</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975574</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975578</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975577</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-975576</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-948021</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975574</externalid>
    <name>Reactions specific to the hybrid N-glycan synthesis pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975574</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10350967</externalid>
        <name>MGAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-975574</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975576</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975578</externalid>
    <name>Reactions specific to the complex N-glycan synthesis pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975578</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350869</externalid>
        <name>MAN2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7T2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389539</externalid>
        <name>CHST10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353214</externalid>
        <name>FUT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387369</externalid>
        <name>FUCA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389532</externalid>
        <name>CHST8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C0LMH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387378</externalid>
        <name>FUT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350875</externalid>
        <name>MAN2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M671</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350886</externalid>
        <name>MGAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1031635</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031642</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60625</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1031636</externalid>
        <name>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAcl-(1-&gt;4)-beta-D-GlcNAc}-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60651</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31107</externalid>
        <name>L-fucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>2181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786328</externalid>
        <name>3-O-sulfo-beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86335</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29656</externalid>
        <name>D-mannopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4208</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>975928</externalid>
        <name>N-glycan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59520</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693932</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6786365</externalid>
        <name>beta-D-glucuronosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>86336</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5693928</externalid>
        <name>beta-D-galactosyl-(1-&gt;3)-N-acetyl-D-glucosaminyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18915</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-975578</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975576</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975577</externalid>
    <name>N-Glycan antennae elongation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975577</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>MGAT4A</name>
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          </protein>
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      <gene>
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        <name>MGAT4B</name>
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              <externalid>A6QQ63</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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  <biosystem>
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    <name>O-linked glycosylation</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5173105</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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          </protein>
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        <name>ADAMTS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419964</externalid>
        <name>FUT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348243</externalid>
        <name>GALNT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348223</externalid>
        <name>GALNT12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348247</externalid>
        <name>GALNT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403321</externalid>
        <name>B3GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348271</externalid>
        <name>GALNT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420067</externalid>
        <name>FKTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376000</externalid>
        <name>ADAMTS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419939</externalid>
        <name>MMRN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379708</externalid>
        <name>POMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376035</externalid>
        <name>SBSPON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348182</externalid>
        <name>MUC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375977</externalid>
        <name>SPON1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GLX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375990</externalid>
        <name>ADAMTS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348425</externalid>
        <name>B3GNT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376015</externalid>
        <name>ADAMTS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376030</externalid>
        <name>ADAMTSL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403301</externalid>
        <name>POMGNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5NDF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373476</externalid>
        <name>ADAMTS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348227</externalid>
        <name>GALNT13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375961</externalid>
        <name>ADAMTSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348496</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348231</externalid>
        <name>GALNT14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420075</externalid>
        <name>FKRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MET8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348484</externalid>
        <name>GCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376040</externalid>
        <name>SEMA5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360972</externalid>
        <name>C1GALT1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376102</externalid>
        <name>ADAMTS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361788</externalid>
        <name>ADAMTS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376083</externalid>
        <name>ADAMTS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8S3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348409</externalid>
        <name>B3GNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376005</externalid>
        <name>ADAMTS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N303</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348405</externalid>
        <name>B3GNTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348429</externalid>
        <name>B3GNT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348259</externalid>
        <name>GALNT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361780</externalid>
        <name>ADAMTS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79331</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379727</externalid>
        <name>POMGNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T015</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420098</externalid>
        <name>CRPPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M410</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360968</externalid>
        <name>C1GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340462</externalid>
        <name>SEMA5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348174</externalid>
        <name>MUC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376025</externalid>
        <name>ADAMTSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376060</externalid>
        <name>THSD7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389510</externalid>
        <name>CHST4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379747</externalid>
        <name>LARGE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361784</externalid>
        <name>ADAMTS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345728</externalid>
        <name>MMRN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348492</externalid>
        <name>GCNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348215</externalid>
        <name>GALNT10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N554</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419933</externalid>
        <name>EMID1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940862</externalid>
        <name>CDP-ribitol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940812</externalid>
        <name>D-ribitol 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57695</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5173214</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-913709</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8931838</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5173105</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5173214</externalid>
    <name>O-glycosylation of TSR domain-containing proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5173214</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334052</externalid>
        <name>THBS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376078</externalid>
        <name>ADAMTS16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7N4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376005</externalid>
        <name>ADAMTS19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N303</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376065</externalid>
        <name>THSD7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376055</externalid>
        <name>THSD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376306</externalid>
        <name>POFUT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376000</externalid>
        <name>ADAMTS17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361780</externalid>
        <name>ADAMTS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79331</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373480</externalid>
        <name>ADAMTS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376020</externalid>
        <name>ADAMTSL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIY2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376035</externalid>
        <name>SBSPON</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375977</externalid>
        <name>SPON1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9GLX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375990</externalid>
        <name>ADAMTS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376015</externalid>
        <name>ADAMTS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340462</externalid>
        <name>SEMA5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376030</externalid>
        <name>ADAMTSL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375951</externalid>
        <name>ADAMTS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376070</externalid>
        <name>ADAMTS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376025</externalid>
        <name>ADAMTSL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376060</externalid>
        <name>THSD7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10373476</externalid>
        <name>ADAMTS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376225</externalid>
        <name>B3GLCT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338618</externalid>
        <name>THBS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375961</externalid>
        <name>ADAMTSL4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375956</externalid>
        <name>ADAMTSL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361784</externalid>
        <name>ADAMTS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376010</externalid>
        <name>ADAMTS20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B900</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376045</externalid>
        <name>SPON2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375985</externalid>
        <name>ADAMTS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376097</externalid>
        <name>ADAMTS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376040</externalid>
        <name>SEMA5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375969</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MX27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375995</externalid>
        <name>ADAMTS15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376102</externalid>
        <name>ADAMTS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376083</externalid>
        <name>ADAMTS18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8S3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376050</externalid>
        <name>SSPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10361788</externalid>
        <name>ADAMTS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9912872</externalid>
        <name>UDP-alpha-D-glucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58885</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9846336</externalid>
        <name>GDP-beta-L-fucose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5173214</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5173105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-913709</externalid>
    <name>O-linked glycosylation of mucins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-913709</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348223</externalid>
        <name>GALNT12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387789</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348413</externalid>
        <name>B3GNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348247</externalid>
        <name>GALNT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348255</externalid>
        <name>GALNT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QA59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348271</externalid>
        <name>GALNT18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348401</externalid>
        <name>B3GNT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348178</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348158</externalid>
        <name>MUC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M633</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348182</externalid>
        <name>MUC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348275</externalid>
        <name>GALNTL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0Q1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348425</externalid>
        <name>B3GNT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348219</externalid>
        <name>GALNT11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350956</externalid>
        <name>B4GALT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348211</externalid>
        <name>GALNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q07537</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348227</externalid>
        <name>GALNT13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348496</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348231</externalid>
        <name>GALNT14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LM69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348484</externalid>
        <name>GCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351354</externalid>
        <name>ST6GALNAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360972</externalid>
        <name>C1GALT1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348409</externalid>
        <name>B3GNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348397</externalid>
        <name>B3GNT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348405</externalid>
        <name>B3GNTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NK42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348429</externalid>
        <name>B3GNT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348259</externalid>
        <name>GALNT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350950</externalid>
        <name>B4GALT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348263</externalid>
        <name>GALNT15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348417</externalid>
        <name>B3GNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348235</externalid>
        <name>GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348170</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360968</externalid>
        <name>C1GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348174</externalid>
        <name>MUC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348162</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348421</externalid>
        <name>B3GNT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389510</externalid>
        <name>CHST4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348267</externalid>
        <name>GALNTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348279</externalid>
        <name>GALNT17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9U7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348239</externalid>
        <name>GALNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348488</externalid>
        <name>GCNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YQE1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348492</externalid>
        <name>GCNT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348215</externalid>
        <name>GALNT10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N554</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348251</externalid>
        <name>GALNT7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348243</externalid>
        <name>GALNT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKQ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9793074</externalid>
        <name>UDP-alpha-D-galactose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>66914</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773097</externalid>
        <name>UDP-N-acetyl-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57847</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-977068</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-913709</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5173105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-977068</externalid>
    <name>Termination of O-glycan biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-977068</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348174</externalid>
        <name>MUC15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351244</externalid>
        <name>siat4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6H8M9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348162</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351248</externalid>
        <name>ST3GAL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351252</externalid>
        <name>ST3GAL-IV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70E76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350893</externalid>
        <name>ST6GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M347</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348178</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351240</externalid>
        <name>ST3GAL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D960</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351324</externalid>
        <name>ST6GALNAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348158</externalid>
        <name>MUC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M633</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348182</externalid>
        <name>MUC20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6U9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351354</externalid>
        <name>ST6GALNAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348170</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5A7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773107</externalid>
        <name>CMP-N-acetyl-beta-neuraminate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57812</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-977068</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-913709</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8931838</externalid>
    <name>DAG1 glycosylations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8931838</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10403321</externalid>
        <name>B3GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347076</externalid>
        <name>SLC35A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403301</externalid>
        <name>POMGNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5NDF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363580</externalid>
        <name>B4GAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379704</externalid>
        <name>POMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0MVC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379743</externalid>
        <name>LARGE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403330</externalid>
        <name>POMK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389539</externalid>
        <name>CHST10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M1B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420067</externalid>
        <name>FKTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420071</externalid>
        <name>RXYLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379747</externalid>
        <name>LARGE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379727</externalid>
        <name>POMGNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T015</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379708</externalid>
        <name>POMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420075</externalid>
        <name>FKRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MET8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420098</externalid>
        <name>CRPPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M410</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403430</externalid>
        <name>MGAT5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737133</externalid>
        <name>cytidine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942172</externalid>
        <name>adenosine 3',5'-bismonophosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58343</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5654896</externalid>
        <name>UDP-alpha-D-glucuronate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58052</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940862</externalid>
        <name>CDP-ribitol(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57608</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737132</externalid>
        <name>CDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58069</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940812</externalid>
        <name>D-ribitol 5-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57695</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9773099</externalid>
        <name>UDP-alpha-D-xylose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57632</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5367926</externalid>
        <name>3'-phosphonato-5'-adenylyl sulfate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58339</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8932506</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8932504</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8932505</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9939291</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8931838</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5173105</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8932506</externalid>
    <name>DAG1 core M1 glycosylations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8932506</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10379727</externalid>
        <name>POMGNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T015</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379708</externalid>
        <name>POMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379704</externalid>
        <name>POMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0MVC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8932506</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8931838</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8932504</externalid>
    <name>DAG1 core M2 glycosylations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8932504</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10379727</externalid>
        <name>POMGNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T015</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379708</externalid>
        <name>POMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379704</externalid>
        <name>POMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0MVC9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403430</externalid>
        <name>MGAT5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8932504</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8931838</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8932505</externalid>
    <name>DAG1 core M3 glycosylations</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8932505</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10403321</externalid>
        <name>B3GALNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403301</externalid>
        <name>POMGNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5NDF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379708</externalid>
        <name>POMT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL72</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379704</externalid>
        <name>POMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0MVC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403330</externalid>
        <name>POMK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379695</externalid>
        <name>DAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDA4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940707</externalid>
        <name>UDP-N-acetyl-alpha-D-galactosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>67138</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8932505</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8931838</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9939291</externalid>
    <name>Matriglycan biosynthesis on DAG1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>FKRP</name>
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      <gene>
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      <gene>
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        <name>FKTN</name>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9737140</externalid>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SUZ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317185</externalid>
        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321432</externalid>
        <name>CDCA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375286</externalid>
        <name>TOP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370098</externalid>
        <name>TRIM27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334314</externalid>
        <name>HDAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DDX17</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>STAG1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTBP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP4</externalid>
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          </protein>
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      <gene>
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        <name>SMC1A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97593</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PHC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFG7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335994</externalid>
        <name>NR3C1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MN19</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>SENP5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TP53BP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDS6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2I</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DNMT3B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVT5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ESR1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333269</externalid>
        <name>DNMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312246</externalid>
        <name>PCNA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBW4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375096</externalid>
        <name>SATB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N426</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346854</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335834</externalid>
        <name>VDR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5J5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374377</externalid>
        <name>SAFB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJP2</externalid>
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          </protein>
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      <gene>
        <externalid>10347409</externalid>
        <name>PIAS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ9</externalid>
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          </protein>
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      <gene>
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        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>IKBKE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
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          </protein>
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      <gene>
        <externalid>10370862</externalid>
        <name>SP3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LST8</externalid>
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          </protein>
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      <gene>
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        <name>SEC13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
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        <externalid>39257</externalid>
        <name>rifampicin</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>28077</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760867</externalid>
        <name>chenodeoxycholate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>36234</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>cortisol</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>corticosterone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16827</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>1301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332984</externalid>
        <name>bicyclo[3.3.0]oct-2-ene</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77361</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-3215018</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3108232</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2990846</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
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    </linkedsystems>
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  <biosystem>
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      <taxnode>
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              <externalid>A0A3Q1M137</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369758</externalid>
        <name>SUMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QV3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>SAE1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VE14</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RWDD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2B3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369694</externalid>
        <name>SUMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61955</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>SENP5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MBS6</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10369647</externalid>
        <name>UBA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV12</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369681</externalid>
        <name>SENP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
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          <protein>
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              <externalid>A6H744</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SENP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG84</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3065679</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3065676</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3065678</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-3215018</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2990846</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3065679</externalid>
    <name>SUMO is proteolytically processed</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3065679</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10347413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369758</externalid>
        <name>SUMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369685</externalid>
        <name>SENP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369694</externalid>
        <name>SUMO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61955</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369681</externalid>
        <name>SENP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369677</externalid>
        <name>SENP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3065679</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3215018</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3065676</externalid>
    <name>SUMO is conjugated to E1 (UBA2:SAE1)</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SAE1</name>
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          <protein>
            <xref>
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              <externalid>A2VE14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3065676</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3215018</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3065678</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
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      </taxnode>
    </taxonomy>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3215018</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <taxnode>
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          <protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>rifampicin</name>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>193021</externalid>
        <name>(24S)-24-hydroxycholesterol</name>
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          <externalid>34310</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30643</externalid>
        <name>cortisol</name>
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          <externalid>17650</externalid>
        </xref>
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      <smallmolecule>
        <externalid>32791</externalid>
        <name>corticosterone</name>
        <xref>
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          <externalid>16827</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32251</externalid>
        <name>aldosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27584</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>34315</externalid>
        <name>11-deoxycorticosterone</name>
        <xref>
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          <externalid>16973</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37439</externalid>
        <name>(22S)-22-hydroxycholesterol</name>
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          <externalid>1301</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>bicyclo[3.3.0]oct-2-ene</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77361</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-4090294</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3108232</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3232142</externalid>
    <name>SUMOylation of ubiquitinylation proteins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3232142</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10370098</externalid>
        <name>TRIM27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351824</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317121</externalid>
        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317169</externalid>
        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317223</externalid>
        <name>NUP155</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317113</externalid>
        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317131</externalid>
        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317235</externalid>
        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317207</externalid>
        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317197</externalid>
        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317193</externalid>
        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317151</externalid>
        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317179</externalid>
        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317227</externalid>
        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317201</externalid>
        <name>NUP85</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370094</externalid>
        <name>PIAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312799</externalid>
        <name>PIAS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317155</externalid>
        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H744</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328816</externalid>
        <name>MDM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317143</externalid>
        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317159</externalid>
        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317231</externalid>
        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370057</externalid>
        <name>PML</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317163</externalid>
        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP54</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP214</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AAAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QCG0</externalid>
            </xref>
          </protein>
        </entity>
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        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3108232</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <organism_specific_biosystem />
    </biosystemtype>
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        <name>TOPORS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N329</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP58</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SUMO2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEH1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY75</externalid>
            </xref>
          </protein>
        </entity>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP62</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP210</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP205</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4S4</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>NUP37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP160</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP133</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RANBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POM121C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP93</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJZ5</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC98</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PIAS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP50</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZD9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP188</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>NUP88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJI3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317135</externalid>
        <name>NUPL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDG6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317211</externalid>
        <name>NUP43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317173</externalid>
        <name>NUP98</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RAE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9A4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NUP54</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>NUP107</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317139</externalid>
        <name>NUP153</name>
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        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943619</externalid>
        <name>L-lysinium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32551</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5689603</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5689880</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5689896</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5689877</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5689901</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5688426</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5689603</externalid>
    <name>UCH proteinases</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5689603</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10386506</externalid>
        <name>UCHL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23356</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C0S9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385769</externalid>
        <name>ACTR8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372524</externalid>
        <name>HIST3H2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385789</externalid>
        <name>INO80D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371765</externalid>
        <name>OGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357925</externalid>
        <name>HCFC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385823</externalid>
        <name>FOXK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW83</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372509</externalid>
        <name>H2AC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386510</externalid>
        <name>UCHL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385793</externalid>
        <name>INO80E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385785</externalid>
        <name>TFPT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385819</externalid>
        <name>FOXK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MP14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385757</externalid>
        <name>NFRKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386634</externalid>
        <name>SENP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386623</externalid>
        <name>MBD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382576</externalid>
        <name>UCHL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9XSJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370484</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPW5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385761</externalid>
        <name>INO80</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>49609</externalid>
        <name>ACTG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385773</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QIL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374651</externalid>
        <name>NEDD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346872</externalid>
        <name>RUVBL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385805</externalid>
        <name>BAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385777</externalid>
        <name>INO80C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386619</externalid>
        <name>MBD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385781</externalid>
        <name>YY1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7T6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385813</externalid>
        <name>ASXL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385809</externalid>
        <name>ASXL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTR5</name>
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              <externalid>G3N1W1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370626</externalid>
        <name>ACTL6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371753</externalid>
        <name>MCRS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6E804</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335866</externalid>
        <name>ESR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319813</externalid>
        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386696</externalid>
        <name>ZRANB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
        <entity>
          <protein>
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              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OTUB2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MZJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OTUD7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ13</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328454</externalid>
        <name>APC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MV51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386452</externalid>
        <name>OTUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y1</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5689896</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5688426</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Josephin domain DUBs</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>VCP</name>
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          <protein>
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              <externalid>G3X757</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385435</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4J1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385447</externalid>
        <name>JOSD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME39</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385425</externalid>
        <name>ATXN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H799</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385439</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MF75</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385415</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMV2</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10385419</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKN</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5689877</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5688426</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5689901</externalid>
    <name>Metalloprotease DUBs</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>P0C0S9</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>Q08DL2</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>A4IFU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MRN2</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ABRAXAS2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MIX0</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>F1MYX8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BABAM1</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>Q17QP9</externalid>
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          </protein>
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      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
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          </protein>
        </entity>
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      <gene>
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        <name>H2AC10</name>
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          <protein>
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              <externalid>A0A3Q1MDK7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>KAT2B</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MLT2</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10326349</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RS49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BABAM2</name>
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          <protein>
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              <externalid>A6QQW8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NLRP3</name>
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          <protein>
            <xref>
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              <externalid>A6QLE5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MYSM1</name>
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          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>UBB</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MF62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BRCC3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A5PJP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312847</externalid>
        <name>ABRAXAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9P1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10372505</externalid>
        <name>LOC614881</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A0A0MP93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>STAMBP</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q17QR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312873</externalid>
        <name>BARD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UIMC1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3N0S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5689901</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5688426</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8852135</externalid>
    <name>Protein ubiquitination</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8852135</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406947</externalid>
        <name>PEX12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381563</externalid>
        <name>RAD18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385138</externalid>
        <name>PRKDC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311676</externalid>
        <name>UBE2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352232</externalid>
        <name>UBE2Q2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8866652</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8866654</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8852135</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8866652</externalid>
    <name>Synthesis of active ubiquitin: roles of E1 and E2 enzymes</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10352176</externalid>
        <name>UBE2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370516</externalid>
        <name>USP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N556</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10382440</externalid>
        <name>OTULIN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352212</externalid>
        <name>UBE2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61085</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347247</externalid>
        <name>USP9X</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E630</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352240</externalid>
        <name>UBE2R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352188</externalid>
        <name>UBE2E3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9X7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386409</externalid>
        <name>USP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3P2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352254</externalid>
        <name>UBE2Z</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1X8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352250</externalid>
        <name>UBE2W</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H795</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10352320</externalid>
        <name>UBA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311672</externalid>
        <name>UBE2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352316</externalid>
        <name>UBA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMV5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10386510</externalid>
        <name>UCHL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBG8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352236</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N2T8</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10389333</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352172</externalid>
        <name>UBE2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>E3 ubiquitin ligases ubiquitinate target proteins</name>
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      <taxnode>
        <taxid>9913</taxid>
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        <entity>
          <protein>
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              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324095</externalid>
        <name>UBE2D3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312825</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406929</externalid>
        <name>PEX13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5B1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319949</externalid>
        <name>PAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319945</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RNF20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDP1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SKIC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HLTF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WAC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403906</externalid>
        <name>RNF144A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406939</externalid>
        <name>PEX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PXMP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RRAGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352172</externalid>
        <name>UBE2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1X1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405052</externalid>
        <name>SHPRH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319937</externalid>
        <name>CDC73</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404921</externalid>
        <name>RNF40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404035</externalid>
        <name>RNF181</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319941</externalid>
        <name>CTR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2D1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <externalid>A0A3Q1MJF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PEX14</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4B1</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10331208</externalid>
        <name>BCL10</name>
        <entity>
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              <externalid>Q17QJ6</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>G3MWH4</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>H2BC12</name>
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          </protein>
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      </gene>
      <gene>
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              <externalid>G3N1R5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2N</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>UBB</name>
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              <externalid>P0CG53</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1MJU1</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>E1BAA6</externalid>
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          </protein>
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      <gene>
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        <name>PCNA</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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        <name>HIST1H2BI</name>
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          <protein>
            <xref>
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              <externalid>F2Z4E8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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              <externalid>P63048</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>A4FUD4</externalid>
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          </protein>
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      <gene>
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              <externalid>G5E6T5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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    <smallmolecules>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8866654</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8852135</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-9907900</externalid>
    <name>Proteasome assembly</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9907900</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>POMP</name>
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              <externalid>Q3SZV5</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F1MBI1</externalid>
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          </protein>
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      <gene>
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              <externalid>Q5E9K0</externalid>
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          </protein>
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      <gene>
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        <name>PSMD6</name>
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              <externalid>F1MXE4</externalid>
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      <gene>
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        <name>PSMC2</name>
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              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC3</name>
        <entity>
          <protein>
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              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
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              <externalid>A0A3Q1N077</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PSMG4</name>
        <entity>
          <protein>
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              <externalid>F1MDD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB6</name>
        <entity>
          <protein>
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              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418817</externalid>
        <name>PSME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
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          <protein>
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              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB9</name>
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              <externalid>Q3SZC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
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              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418677</externalid>
        <name>PSMG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL24</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244088</externalid>
        <name>PSMB10</name>
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          <protein>
            <xref>
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              <externalid>Q3T0T1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418784</externalid>
        <name>PSMD4</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A452DI44</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418673</externalid>
        <name>PSMG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244095</externalid>
        <name>PSMB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T112</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418695</externalid>
        <name>PSMG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NKS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418730</externalid>
        <name>PSMB11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418754</externalid>
        <name>PSMD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ19</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418762</externalid>
        <name>PSMD5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418821</externalid>
        <name>PSME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9907900</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8873719</externalid>
    <name>RAB geranylgeranylation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8873719</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10401835</externalid>
        <name>RAB13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399896</externalid>
        <name>RAB11B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397238</externalid>
        <name>RAB6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398651</externalid>
        <name>RAB30</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367772</externalid>
        <name>RAB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391566</externalid>
        <name>RAB31</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401799</externalid>
        <name>PTP4A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399733</externalid>
        <name>RAB8B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391558</externalid>
        <name>RAB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401937</externalid>
        <name>RAB40B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401889</externalid>
        <name>RAB20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391550</externalid>
        <name>RAB9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401901</externalid>
        <name>RAB25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399837</externalid>
        <name>RAB4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398663</externalid>
        <name>RAB39A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399855</externalid>
        <name>RAB33A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401877</externalid>
        <name>RAB15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332907</externalid>
        <name>RAB3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11023</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401881</externalid>
        <name>RAB17</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391272</externalid>
        <name>RAB37</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401913</externalid>
        <name>RAB32</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391576</externalid>
        <name>RAB5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401943</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3A1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394430</externalid>
        <name>RABGGTA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401885</externalid>
        <name>RAB19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC27</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391572</externalid>
        <name>RAB4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401893</externalid>
        <name>RAB21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401851</externalid>
        <name>RAB3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10949</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391562</externalid>
        <name>RAB18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392686</externalid>
        <name>RAB27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394434</externalid>
        <name>RABGGTB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398051</externalid>
        <name>RAB33B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399797</externalid>
        <name>RAB7B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DE8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401839</externalid>
        <name>RAB38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9C0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401847</externalid>
        <name>RAB3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10948</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366938</externalid>
        <name>RAB1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391232</externalid>
        <name>RAB44</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346112</externalid>
        <name>RAB27B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HZJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394442</externalid>
        <name>CHM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399701</externalid>
        <name>RAB35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401897</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401843</externalid>
        <name>RAB2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC58</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401817</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2I0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391228</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391580</externalid>
        <name>RAB6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368760</externalid>
        <name>RAB8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401871</externalid>
        <name>RAB12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353112</externalid>
        <name>RAB5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401933</externalid>
        <name>RAB39B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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      <smallmolecule>
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      <gene>
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        <name>MGAT4A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>O77836</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406207</externalid>
        <name>RCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405979</externalid>
        <name>AMBN</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406221</externalid>
        <name>SERPINA10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJ69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366516</externalid>
        <name>MEN1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406089</externalid>
        <name>CYR61</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC35</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406015</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NIX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406135</externalid>
        <name>IGFBP7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPP2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SERPIND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R4P6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325406</externalid>
        <name>APOA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15497</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q27967</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380765</externalid>
        <name>KTN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406043</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X724</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405983</externalid>
        <name>AMELX</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02817</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345874</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N9Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346144</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LEU1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387627</externalid>
        <name>MIA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356798</externalid>
        <name>PNPLA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5T0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323730</externalid>
        <name>C3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2UVX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396126</externalid>
        <name>BPIFB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI67</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406011</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405971</externalid>
        <name>AFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ57</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406195</externalid>
        <name>PRKCSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ENAM</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>FN1</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LTBP1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>FGA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QND5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>VCAN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GOLM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLA8</externalid>
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          </protein>
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      <gene>
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        <name>MEPE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323691</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH06</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330776</externalid>
        <name>CHRDL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MAZ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325534</externalid>
        <name>APOA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AMTN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF93</externalid>
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          </protein>
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      <gene>
        <externalid>10374634</externalid>
        <name>ADAM10</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q10741</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TNC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKE5</externalid>
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          </protein>
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      <gene>
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        <name>CALU</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NC75</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>CDH2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>DMP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJM1</externalid>
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          </protein>
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      <gene>
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        <name>PDIA6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F6QH94</externalid>
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          </protein>
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      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>E1BJU2</externalid>
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      <gene>
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        <name>IGFBP1</name>
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              <externalid>P24591</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CP</name>
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      <gene>
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              <externalid>F6RJ01</externalid>
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      <gene>
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          <protein>
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              <externalid>Q3T0A9</externalid>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8957275</externalid>
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      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
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  <biosystem>
    <externalid>R-BTA-9857492</externalid>
    <name>Protein lipoylation</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9857492</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>GCSH</name>
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              <externalid>P20821</externalid>
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              <externalid>F1N690</externalid>
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      <gene>
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              <externalid>E1BI46</externalid>
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        </entity>
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      <gene>
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              <externalid>O46419</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387139</externalid>
        <name>DBT</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P11181</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10390650</externalid>
        <entity>
          <protein>
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              <externalid>A0A3Q1NKC6</externalid>
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      <gene>
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        <name>LIAS</name>
        <entity>
          <protein>
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              <externalid>Q5BIP7</externalid>
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          </protein>
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        <name>DLST</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1MHE5</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>NDUFAB1</name>
        <entity>
          <protein>
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              <externalid>G3X6L0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FDX1</name>
        <entity>
          <protein>
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              <externalid>P00257</externalid>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
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        <externalid>2395455</externalid>
        <name>di-mu-sulfido-diiron(1+)</name>
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          <externalid>33738</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395453</externalid>
        <name>di-mu-sulfido-diiron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33737</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760796</externalid>
        <name>hydrosulfide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29919</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>37051</externalid>
        <name>5'-deoxyadenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17319</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2564711</externalid>
        <name>tetra-mu3-sulfido-tetrairon</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>49883</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9857492</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-597592</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2980736</externalid>
    <name>Peptide hormone metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2980736</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ACE</name>
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          </protein>
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      <gene>
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        <name>SEC11A</name>
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          </protein>
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        <name>GHRL</name>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>GIP</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>EXOC5</name>
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          </protein>
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      <gene>
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        <name>PLA2G7</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>CPB1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>REN</name>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>BCHE</name>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>INHBE</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-264876</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-422085</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2022377</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400508</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209952</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2980736</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-264876</externalid>
    <name>Insulin processing</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-264876</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333937</externalid>
        <name>EXOC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333941</externalid>
        <name>EXOC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343381</externalid>
        <name>SLC30A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N919</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325510</externalid>
        <name>P4HB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q9Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333921</externalid>
        <name>EXOC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416136</externalid>
        <name>ERO1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333929</externalid>
        <name>EXOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333925</externalid>
        <name>EXOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333949</externalid>
        <name>EXOC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNT5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333945</externalid>
        <name>EXOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8C2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343372</externalid>
        <name>SLC30A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B955</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333933</externalid>
        <name>EXOC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N005</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-264876</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-422085</externalid>
    <name>Synthesis, secretion, and deacylation of Ghrelin</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-422085</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409868</externalid>
        <name>BCHE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32749</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341605</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341597</externalid>
        <name>SEC11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67810</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341613</externalid>
        <name>SPCS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337045</externalid>
        <name>GHRL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341555</externalid>
        <name>MBOAT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409875</externalid>
        <name>PLA2G7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316434</externalid>
        <name>INS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338769</externalid>
        <name>ob</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8BLB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341609</externalid>
        <name>SPCS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333998</externalid>
        <name>PCSK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341580</externalid>
        <name>GH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338133</externalid>
        <name>IGF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07455</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341601</externalid>
        <name>SEC11C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>422040</externalid>
        <name>octanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28837</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422018</externalid>
        <name>fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>35366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316630</externalid>
        <name>decanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27689</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-422085</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2022377</externalid>
    <name>Metabolism of Angiotensinogen to Angiotensins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2022377</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10387314</externalid>
        <name>CES1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362931</externalid>
        <name>ACE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12820</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363699</externalid>
        <name>CPA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BK06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363707</externalid>
        <name>CPB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316649</externalid>
        <name>CTSD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362977</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362955</externalid>
        <name>ATP6AP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81134</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363703</externalid>
        <name>CPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00732</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362959</externalid>
        <name>REN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355461</externalid>
        <name>LOC100139881</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8U1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362897</externalid>
        <name>MME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362942</externalid>
        <name>ENPEP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332012</externalid>
        <name>CTSZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05689</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10362908</externalid>
        <name>ACE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344606</externalid>
        <name>LOC509956</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335320</externalid>
        <name>AGT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01017</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422992</externalid>
        <name>alcohol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2022377</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-400508</externalid>
    <name>Incretin synthesis, secretion, and inactivation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-400508</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335693</externalid>
        <name>GRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q863C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338769</externalid>
        <name>ob</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8BLB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409884</externalid>
        <name>DPP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338773</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336325</externalid>
        <name>GIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337105</externalid>
        <name>FFAR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-381771</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400511</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-400508</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381771</externalid>
    <name>Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381771</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335693</externalid>
        <name>GRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q863C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>55378</externalid>
        <name>GNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338769</externalid>
        <name>ob</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8BLB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409884</externalid>
        <name>DPP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322986</externalid>
        <name>GCG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01272</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324408</externalid>
        <name>GNAT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0C7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338773</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319772</externalid>
        <name>GNG13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319788</externalid>
        <name>GNB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337105</externalid>
        <name>FFAR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444211</externalid>
        <name>all-cis-icosa-8,11,14-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53486</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9911739</externalid>
        <name>all-cis-5,8,11,14,17-icosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58562</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444196</externalid>
        <name>all-cis-docosa-7,10,13,16-tetraenoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53487</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38773</externalid>
        <name>alpha-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27432</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>32149</externalid>
        <name>elaidic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>27997</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31879</externalid>
        <name>magnesium distearate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>9254</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38767</externalid>
        <name>tetradecanoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28875</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762304</externalid>
        <name>(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>77224</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>444165</externalid>
        <name>all-cis-icosa-11,14,17-trienoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53460</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38771</externalid>
        <name>gamma-linolenic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29412</externalid>
        <name>D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>4167</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>42454</externalid>
        <name>palmitoleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264629</externalid>
        <name>acetylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15355</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381771</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400508</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-400511</externalid>
    <name>Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-400511</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10409884</externalid>
        <name>DPP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81425</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336997</externalid>
        <name>GPR41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338773</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5H9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336325</externalid>
        <name>GIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8848352</externalid>
        <name>hexadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>7896</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9673043</externalid>
        <name>oleate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30823</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316156</externalid>
        <name>dodecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18262</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5332987</externalid>
        <name>oleoyl ethanolamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71466</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9946985</externalid>
        <name>pentadecanoate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>78795</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-400511</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-400508</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209952</externalid>
    <name>Peptide hormone biosynthesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209952</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336063</externalid>
        <name>INHBE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336055</externalid>
        <name>INHBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319676</externalid>
        <name>POMC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01190</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333998</externalid>
        <name>PCSK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336049</externalid>
        <name>FSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336059</externalid>
        <name>INHBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-209822</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-209952</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2980736</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-209822</externalid>
    <name>Glycoprotein hormones</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-209822</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336063</externalid>
        <name>INHBE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336055</externalid>
        <name>INHBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330353</externalid>
        <name>INHBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07995</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336049</externalid>
        <name>FSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04837</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330349</externalid>
        <name>INHA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07994</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336059</externalid>
        <name>INHBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332694</externalid>
        <name>TSHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-209822</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-209952</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-381426</externalid>
    <name>Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-381426</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334022</externalid>
        <name>SPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404272</externalid>
        <name>MSLN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QP39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406039</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406259</externalid>
        <name>VGF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391788</externalid>
        <name>CST3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01035</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325414</externalid>
        <name>APOA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81644</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406177</externalid>
        <name>MXRA8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405965</externalid>
        <name>FAM20C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXQ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406073</externalid>
        <name>CHGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T885</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323051</externalid>
        <name>GAS6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359216</externalid>
        <name>SDC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384930</externalid>
        <name>CKAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>90292</externalid>
        <name>FBN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P98133</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406251</externalid>
        <name>TMEM132A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406131</externalid>
        <name>IGFBP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05717</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338173</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406007</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEX5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>APOL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPR4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406167</externalid>
        <name>MFGE8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338163</externalid>
        <name>IGFBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05716</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345862</externalid>
        <name>AHSG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P12763</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346235</externalid>
        <name>TF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6N3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406201</externalid>
        <name>PRSS23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406241</externalid>
        <name>STC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406031</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338110</externalid>
        <name>MBTPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333825</externalid>
        <name>ALB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T897</externalid>
            </xref>
          </protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10374477</externalid>
        <name>DMP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406187</externalid>
        <name>PDIA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QH94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325439</externalid>
        <name>APOE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T881</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330780</externalid>
        <name>FSTL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58D84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321746</externalid>
        <name>KNG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8C8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338177</externalid>
        <name>PAPPA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BF00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318639</externalid>
        <name>FGF23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338147</externalid>
        <name>IGFBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P24591</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392862</externalid>
        <name>DNAJC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N036</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406083</externalid>
        <name>CSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347778</externalid>
        <name>CP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N076</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341386</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RJ01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406229</externalid>
        <name>SHISA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0A9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-381426</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5676934</externalid>
    <name>Protein repair</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5676934</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10383791</externalid>
        <name>MSRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383795</externalid>
        <name>MSRB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383804</externalid>
        <name>MSRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P54149</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383787</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10383811</externalid>
        <name>PCMT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676935</externalid>
        <name>L-methionine (S)-S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49031</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5676947</externalid>
        <name>L-methionine (R)-S-oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49032</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687527</externalid>
        <name>N-methyl-D-aspartic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>31882</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841147</externalid>
        <name>L-beta-isoaspartate residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>90596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943622</externalid>
        <name>L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57844</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5676934</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5683826</externalid>
    <name>Surfactant metabolism</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5683826</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344946</externalid>
        <name>CSF2RB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337218</externalid>
        <name>ADRA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315790</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336257</externalid>
        <name>ADORA2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKU0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384953</externalid>
        <name>ZDHHC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345600</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MB14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352950</externalid>
        <name>GATA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1M2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342053</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336253</externalid>
        <name>ADORA2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384552</externalid>
        <name>SFTPC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323509</externalid>
        <name>SFTPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384588</externalid>
        <name>NAPSA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342049</externalid>
        <name>SLC34A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384930</externalid>
        <name>CKAP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ME65</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384347</externalid>
        <name>CCDC59</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384562</externalid>
        <name>ADGRF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10336673</externalid>
        <name>P2RY2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384314</externalid>
        <name>ABCA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCR1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384355</externalid>
        <name>LMCD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337226</externalid>
        <name>ADRA2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323517</externalid>
        <name>SFTPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384546</externalid>
        <name>SFTPB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P15781</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387171</externalid>
        <name>ADA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N144</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10365031</externalid>
        <name>CTSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384592</externalid>
        <name>PGA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N373</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114935</externalid>
        <name>inosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17596</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114739</externalid>
        <name>ammonia</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16134</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817232</externalid>
        <name>(R)-adrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71406</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9817233</externalid>
        <name>(R)-noradrenaline(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>72587</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760742</externalid>
        <name>palmitoyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114933</externalid>
        <name>adenosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16335</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5683826</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392499</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9837999</externalid>
    <name>Mitochondrial protein degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9837999</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>10313594</externalid>
        <name>CS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323113</externalid>
        <name>UQCRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405434</externalid>
        <name>SPG7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E2Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386189</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MH73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322700</externalid>
        <name>SLC25A5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416970</externalid>
        <name>SSBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327019</externalid>
        <name>ALAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331757</externalid>
        <name>PDHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11966</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416980</externalid>
        <name>IARS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313705</externalid>
        <name>PCCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322706</externalid>
        <name>SLC25A6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32007</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387893</externalid>
        <name>ALDH1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5P4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322589</externalid>
        <name>COX5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00426</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322956</externalid>
        <name>TFAM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416946</externalid>
        <name>CLPP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323166</externalid>
        <name>MT-ATP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>245913</externalid>
        <name>MRPL12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YR75</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313979</externalid>
        <name>OGDH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148N0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416966</externalid>
        <name>OXSM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXW5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417044</externalid>
        <name>HTRA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNK3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322809</externalid>
        <name>NDUFA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02370</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377474</externalid>
        <name>HSPA9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323148</externalid>
        <name>ATP5F1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416950</externalid>
        <name>CLPX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N155</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316071</externalid>
        <name>BDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q02337</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405456</externalid>
        <name>PMPCA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322745</externalid>
        <name>NDUFV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313604</externalid>
        <name>MDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LG3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410189</externalid>
        <name>ECH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317990</externalid>
        <name>HADH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N338</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313432</externalid>
        <name>ACADSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316082</externalid>
        <name>HMGCS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316303</externalid>
        <name>OXCT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345534</externalid>
        <name>ARG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWN1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10405428</externalid>
        <name>AFG3L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313582</externalid>
        <name>ACO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20004</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387139</externalid>
        <name>DBT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11181</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328604</externalid>
        <name>STAR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28918</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322721</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0E1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACAD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0NXR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317986</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LS03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314260</externalid>
        <name>SUCLG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP5F1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NDUFS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82670</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBD7</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10346461</externalid>
        <name>ALDH18A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJH7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C26H10ORF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7A7</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM3</externalid>
            </xref>
          </protein>
        </entity>
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        <name>DLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N206</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MS25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COX1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6QTG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ECI1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LONP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T842</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10313614</externalid>
        <name>FH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SHMT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP5PO</name>
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          <protein>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>ALDH2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P82923</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HSPD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUZ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NADK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IDH3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148J8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATP5PF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02721</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323105</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10386146</externalid>
        <name>ACOT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327038</externalid>
        <name>FECH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22600</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313260</externalid>
        <name>GLUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323182</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A0N4STN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408114</externalid>
        <name>LDHD</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QNT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1592230</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5617833</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1852241</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1592230</externalid>
    <name>Mitochondrial biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1592230</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357903</externalid>
        <name>GABPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323214</externalid>
        <name>ATP5MJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323160</externalid>
        <name>ATP5F1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05632</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323228</externalid>
        <name>DMAC2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P22027</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323166</externalid>
        <name>MT-ATP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323224</externalid>
        <name>ATP5PO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13621</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385370</externalid>
        <name>SIRT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314253</externalid>
        <name>ACSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371445</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323148</externalid>
        <name>ATP5F1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323190</externalid>
        <name>ATP5PF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02721</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323174</externalid>
        <name>ATP5ME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323218</externalid>
        <name>ATP5MK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313260</externalid>
        <name>GLUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323186</externalid>
        <name>MT-ATP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03929</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323178</externalid>
        <name>ATP5MF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28851</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323182</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A0N4STN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385394</externalid>
        <name>SIRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385406</externalid>
        <name>SIRT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345351</externalid>
        <name>IDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q04467</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323170</externalid>
        <name>ATP5PD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13620</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323202</externalid>
        <name>ATP5MC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32876</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357907</externalid>
        <name>GABPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323198</externalid>
        <name>ATP5MC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323194</externalid>
        <name>ATP5PB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P13619</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323156</externalid>
        <name>ATP5F1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05630</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323152</externalid>
        <name>ATP5F1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323144</externalid>
        <name>ATP5F1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2151201</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8949613</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1592230</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1852241</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2151201</externalid>
    <name>Transcriptional activation of mitochondrial biogenesis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2151201</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10357903</externalid>
        <name>GABPA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345351</externalid>
        <name>IDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q04467</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10313260</externalid>
        <name>GLUD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385370</externalid>
        <name>SIRT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314253</externalid>
        <name>ACSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357907</externalid>
        <name>GABPB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMI3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371445</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385394</externalid>
        <name>SIRT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320067</externalid>
        <name>CYCS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385406</externalid>
        <name>SIRT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5084075</externalid>
        <name>2''-O-acetyl-ADP-D-ribose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76279</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2151201</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1592230</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8949613</externalid>
    <name>Cristae formation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8949613</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323174</externalid>
        <name>ATP5ME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q00361</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323218</externalid>
        <name>ATP5MK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323186</externalid>
        <name>MT-ATP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P03929</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323178</externalid>
        <name>ATP5MF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28851</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323214</externalid>
        <name>ATP5MJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P14790</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323160</externalid>
        <name>ATP5F1E</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PCNT</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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    <description>computationally inferred pathway (not manually curated)</description>
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      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5620912</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5617833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5620920</externalid>
    <name>Cargo trafficking to the periciliary membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5620920</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10379791</externalid>
        <name>TTC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4X0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339615</externalid>
        <name>CCT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333929</externalid>
        <name>EXOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316258</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380043</externalid>
        <name>RAB11FIP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LHY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339627</externalid>
        <name>CCT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339607</externalid>
        <name>CCT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379775</externalid>
        <name>BBS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337059</externalid>
        <name>MCHR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333945</externalid>
        <name>EXOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333933</externalid>
        <name>EXOC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N005</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335500</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380013</externalid>
        <name>PKD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4GZT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380327</externalid>
        <name>ARL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K192</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333937</externalid>
        <name>EXOC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339611</externalid>
        <name>CCT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380333</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380540</externalid>
        <name>ARL13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380021</externalid>
        <name>CNGA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379771</externalid>
        <name>BBS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380277</externalid>
        <name>MKKS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333925</externalid>
        <name>EXOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380337</externalid>
        <name>NPHP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380269</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380017</externalid>
        <name>CNGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379801</externalid>
        <name>RAB3IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339623</externalid>
        <name>CCT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339603</externalid>
        <name>TCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E531</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333941</externalid>
        <name>EXOC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333921</externalid>
        <name>EXOC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380534</externalid>
        <name>PDE6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95142</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381292</externalid>
        <name>RP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380286</externalid>
        <name>ARL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359372</externalid>
        <name>INPP5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379779</externalid>
        <name>BBS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379787</externalid>
        <name>BBS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380006</externalid>
        <name>ARF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379795</externalid>
        <name>BBIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368760</externalid>
        <name>RAB8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV54</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10380314</externalid>
        <name>LZTFL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BBS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EXOC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379612</externalid>
        <name>SMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE57</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>BBS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN34</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
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          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5620916</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620922</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5624138</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5624958</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5620920</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5617833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5620916</externalid>
    <name>VxPx cargo-targeting to cilium</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5620916</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10380006</externalid>
        <name>ARF4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZF2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333937</externalid>
        <name>EXOC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343104</externalid>
        <name>RAB11A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4D5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333941</externalid>
        <name>EXOC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368760</externalid>
        <name>RAB8A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FV54</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333921</externalid>
        <name>EXOC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334440</externalid>
        <name>GBF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333929</externalid>
        <name>EXOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380021</externalid>
        <name>CNGA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>74086</externalid>
        <name>RHO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02699</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316258</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333949</externalid>
        <name>EXOC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333925</externalid>
        <name>EXOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380043</externalid>
        <name>RAB11FIP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LHY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333945</externalid>
        <name>EXOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333933</externalid>
        <name>EXOC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N005</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380017</externalid>
        <name>CNGA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379801</externalid>
        <name>RAB3IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380013</externalid>
        <name>PKD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4GZT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5620916</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620920</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5620922</externalid>
    <name>BBSome-mediated cargo-targeting to cilium</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5620922</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339623</externalid>
        <name>CCT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379787</externalid>
        <name>BBS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379791</externalid>
        <name>TTC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4X0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339603</externalid>
        <name>TCP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E531</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379795</externalid>
        <name>BBIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2W1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339611</externalid>
        <name>CCT4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339615</externalid>
        <name>CCT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380314</externalid>
        <name>LZTFL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380286</externalid>
        <name>ARL6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379771</externalid>
        <name>BBS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU26</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380277</externalid>
        <name>MKKS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379783</externalid>
        <name>BBS7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339627</externalid>
        <name>CCT8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339607</externalid>
        <name>CCT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBH0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379775</externalid>
        <name>BBS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ97</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337059</externalid>
        <name>MCHR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379612</externalid>
        <name>SMO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380269</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NLJ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380273</externalid>
        <name>BBS12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379779</externalid>
        <name>BBS5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335500</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379767</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379801</externalid>
        <name>RAB3IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5620922</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620920</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5624138</externalid>
    <name>Trafficking of myristoylated proteins to the cilium</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5624138</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10380337</externalid>
        <name>NPHP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380333</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381292</externalid>
        <name>RP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z024</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380327</externalid>
        <name>ARL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K192</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114749</externalid>
        <name>GDP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17552</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5624138</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620920</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5624958</externalid>
    <name>ARL13B-mediated ciliary trafficking of INPP5E</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5624958</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359372</externalid>
        <name>INPP5E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380534</externalid>
        <name>PDE6D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95142</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380540</externalid>
        <name>ARL13B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5624958</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5620920</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5620924</externalid>
    <name>Intraflagellar transport</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5620924</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>9619732</externalid>
        <name>TUBB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379676</externalid>
        <name>IFT88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380466</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJC5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380446</externalid>
        <name>DYNC2LI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380438</externalid>
        <name>DYNC2I2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380458</externalid>
        <name>DYNLRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250617</externalid>
        <name>TUBB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9S0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380470</externalid>
        <name>DYNLT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380462</externalid>
        <name>DYNLT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N459</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250624</externalid>
        <name>TUBB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379497</externalid>
        <name>IFT122</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380380</externalid>
        <name>IFT27</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379680</externalid>
        <name>IFT52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619701</externalid>
        <name>TUBA1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380454</externalid>
        <name>DYNLRB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T140</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380384</externalid>
        <name>IFT46</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343824</externalid>
        <name>TUBA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379684</externalid>
        <name>IFT57</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379511</externalid>
        <name>TTC21B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250614</externalid>
        <name>TUBB4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHM5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380428</externalid>
        <name>IFT20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58CS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380396</externalid>
        <name>IFT81</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619736</externalid>
        <name>TUBB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380408</externalid>
        <name>CLUAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380420</externalid>
        <name>IFT70B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379515</externalid>
        <name>WDR35</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380374</externalid>
        <name>C3H1ORF41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17Q88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380400</externalid>
        <name>IFT22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>154751</externalid>
        <name>TUBA4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81948</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379505</externalid>
        <name>IFT140</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B860</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380416</externalid>
        <name>IFT70A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619703</externalid>
        <name>LOC100141266</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380412</externalid>
        <name>IFT56</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MF33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379501</externalid>
        <name>WDR19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Q4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320621</externalid>
        <name>DYNLL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380442</externalid>
        <name>DYNC2I1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320647</externalid>
        <name>DYNLL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61285</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379914</externalid>
        <name>IFT43</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250619</externalid>
        <name>TUBB4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>250593</externalid>
        <name>TUBA1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380388</externalid>
        <name>IFT74</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N626</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380392</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380404</externalid>
        <name>TRAF3IP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5620924</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5617833</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74160</externalid>
    <name>Gene expression (Transcription)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74160</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324463</externalid>
        <name>TGFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N449</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POU2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350066</externalid>
        <name>ZNF514</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342742</externalid>
        <name>CNOT9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316929</externalid>
        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RARG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349602</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M781</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335842</externalid>
        <name>NR2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TTR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MIC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341981</externalid>
        <name>SUV39H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KAT5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353774</externalid>
        <name>E2F4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TIGAR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384621</externalid>
        <name>RMI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371707</externalid>
        <name>KAT6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370172</externalid>
        <name>SCMH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312006</externalid>
        <name>CCNA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JKW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403978</externalid>
        <name>PAX5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MM48</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333327</externalid>
        <name>EZH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7E2Z2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SFRS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350614</externalid>
        <name>ZNF782</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329751</externalid>
        <name>FOXO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394409</externalid>
        <entity>
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              <externalid>A0A3Q1MBQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GADD45A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MTOR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFB4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POU4F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TFAP2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381007</externalid>
        <name>SESN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349546</externalid>
        <name>ZNF140</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370214</externalid>
        <name>CBX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350158</externalid>
        <name>ZNF568</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350504</externalid>
        <name>ZNF74</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312430</externalid>
        <name>CDK6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317701</externalid>
        <name>POLR3GL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314674</externalid>
        <name>CIP29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327558</externalid>
        <name>PHAX</name>
        <entity>
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      <gene>
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        <name>UTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      <smallmolecule>
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        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
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      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50648</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
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      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
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      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>381312</externalid>
        <name>13(S)-HODE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
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      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
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      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
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      <smallmolecule>
        <externalid>9915625</externalid>
        <name>15-deoxy-Delta(12,14)-prostaglandin J2(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85236</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
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      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5317197</externalid>
        <name>semiquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15817</externalid>
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      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
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      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
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      <smallmolecule>
        <externalid>6799728</externalid>
        <name>1,2-naphthoquinone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>34055</externalid>
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      <smallmolecule>
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        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
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      <smallmolecule>
        <externalid>35431</externalid>
        <name>7-methylguanosine 5'-phosphate(1+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>17825</externalid>
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      <smallmolecule>
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        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
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        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      <smallmolecule>
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        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
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      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
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      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>381339</externalid>
        <name>9(S)-HODE</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34496</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
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      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5220989</externalid>
        <name>5-formylcytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76794</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>77016</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5221010</externalid>
        <name>5-carboxycytosine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>76793</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-73864</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-74158</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75944</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-211000</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212165</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74160</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-73864</externalid>
    <name>RNA Polymerase I Transcription</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73864</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ERCC6</name>
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          </protein>
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        <name>MNAT1</name>
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              <externalid>Q3SX39</externalid>
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      </gene>
      <gene>
        <externalid>10315667</externalid>
        <name>UBTF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315893</externalid>
        <name>TWISTNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315877</externalid>
        <name>POLR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315897</externalid>
        <name>POLR1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315798</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N413</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315759</externalid>
        <name>TAF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315871</externalid>
        <name>POLR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315790</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316860</externalid>
        <name>CAVIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315816</externalid>
        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B883</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315881</externalid>
        <name>POLR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315763</externalid>
        <name>TAF1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-73854</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73863</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-73864</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74160</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73854</externalid>
    <name>RNA Polymerase I Promoter Clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73854</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316845</externalid>
        <name>CBX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315820</externalid>
        <name>CHD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315718</externalid>
        <name>MBD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E683</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315824</externalid>
        <name>CHD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Y2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315767</externalid>
        <name>TAF1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315838</externalid>
        <name>MTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315812</externalid>
        <name>RBBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315842</externalid>
        <name>MTA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315830</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315852</externalid>
        <name>GATAD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315667</externalid>
        <name>UBTF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315893</externalid>
        <name>TWISTNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315877</externalid>
        <name>POLR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315897</externalid>
        <name>POLR1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315848</externalid>
        <name>GATAD2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPD8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315798</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N413</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315759</externalid>
        <name>TAF1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315834</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315871</externalid>
        <name>POLR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315790</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315860</externalid>
        <name>ERCC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315771</externalid>
        <name>TAF1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315889</externalid>
        <name>POLR1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315816</externalid>
        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315903</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B883</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315881</externalid>
        <name>POLR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315885</externalid>
        <name>POLR1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QVL1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315702</externalid>
        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315763</externalid>
        <name>TAF1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQD6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-73728</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73762</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73772</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-73854</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73864</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73728</externalid>
    <name>RNA Polymerase I Promoter Opening</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73728</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315718</externalid>
        <name>MBD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E683</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315667</externalid>
        <name>UBTF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73728</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73854</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73762</externalid>
    <name>RNA Polymerase I Transcription Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73762</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315820</externalid>
        <name>CHD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3F6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315871</externalid>
        <name>POLR1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315834</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315790</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315824</externalid>
        <name>CHD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3Y2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315860</externalid>
        <name>ERCC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315771</externalid>
        <name>TAF1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315767</externalid>
        <name>TAF1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315838</externalid>
        <name>MTA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315812</externalid>
        <name>RBBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315842</externalid>
        <name>MTA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2W8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315830</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MJ47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315852</externalid>
        <name>GATAD2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315889</externalid>
        <name>POLR1E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315667</externalid>
        <name>UBTF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCZ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315816</externalid>
        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315893</externalid>
        <name>TWISTNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
        </entity>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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        <entity>
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            </xref>
          </protein>
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        <entity>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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          </protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334318</externalid>
        <name>HDAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346689</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335822</externalid>
        <name>NR1D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M078</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397711</externalid>
        <name>ELL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330023</externalid>
        <name>PRKAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330045</externalid>
        <name>PRKAG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LL38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57955</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30711</externalid>
        <name>all-trans-retinoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15367</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317197</externalid>
        <name>semiquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6799728</externalid>
        <name>1,2-naphthoquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35431</externalid>
        <name>7-methylguanosine 5'-phosphate(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17154</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
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      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
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      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
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      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-674695</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-77075</externalid>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73856</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6807505</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-73857</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74160</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-212436</externalid>
    <name>Generic Transcription Pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-212436</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>TGFB1</name>
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              <externalid>A0A3Q1N449</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350066</externalid>
        <name>ZNF514</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B7G1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342742</externalid>
        <name>CNOT9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB47</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
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      <gene>
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        <name>RARG</name>
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          <protein>
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              <externalid>Q08DD4</externalid>
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      <gene>
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              <externalid>A0A3Q1M781</externalid>
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      <gene>
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        <name>NR2F1</name>
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              <externalid>Q9TTR8</externalid>
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      <gene>
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              <externalid>E1BMS5</externalid>
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      <gene>
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          <sourcename>ChEBI</sourcename>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>all-trans-retinoic acid</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      <smallmolecule>
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        <name>copper(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>glutathionate(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ferriheme a3(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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        <name>copper(1+)</name>
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          <sourcename>ChEBI</sourcename>
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        <name>ammonium</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>semiquinone</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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        <name>phosphatidate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>1,2-naphthoquinone</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>L-glutamine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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        <name>nicotinamide</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57634</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83767</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>374156</externalid>
        <name>estrogen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50114</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-350054</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-383280</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2032785</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2173793</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3700989</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8864260</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878171</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878166</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878159</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8986944</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8953750</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9614085</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9634815</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-212436</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-350054</externalid>
    <name>Notch-HLH transcription pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-350054</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334298</externalid>
        <name>HDAC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334314</externalid>
        <name>HDAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333466</externalid>
        <name>RBPJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334290</externalid>
        <name>HDAC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VD49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333472</externalid>
        <name>NOTCH4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X812</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334280</externalid>
        <name>TBL1X</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B7TCI5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333504</externalid>
        <name>SNW1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334284</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334310</externalid>
        <name>HDAC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334318</externalid>
        <name>HDAC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333490</externalid>
        <name>KAT2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333494</externalid>
        <name>KAT2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333480</externalid>
        <name>MAML2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334302</externalid>
        <name>HDAC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXW3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333476</externalid>
        <name>MAML1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333484</externalid>
        <name>MAMLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334306</externalid>
        <name>HDAC9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334322</externalid>
        <name>HDAC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MDJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324729</externalid>
        <name>NCOR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-350054</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-383280</externalid>
    <name>Nuclear Receptor transcription pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-383280</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10335954</externalid>
        <name>NR1I3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327605</externalid>
        <name>NR1H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335858</externalid>
        <name>NEK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQ15</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335970</externalid>
        <name>NR5A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335922</externalid>
        <name>RARG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335918</externalid>
        <name>RARB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X6X1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335842</externalid>
        <name>NR2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TTR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327601</externalid>
        <name>RXRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335850</externalid>
        <name>PGR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N712</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335878</externalid>
        <name>HNF4A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q7YRQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335934</externalid>
        <name>THRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N8R7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329892</externalid>
        <name>NR4A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V8F0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335906</externalid>
        <name>RXRB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335890</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324733</externalid>
        <name>NCOR2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MY21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335910</externalid>
        <name>RXRG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>ING5</name>
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      <gene>
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        <name>JMY</name>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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            <xref>
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      <gene>
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      <gene>
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      <gene>
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        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
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      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
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      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
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      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317197</externalid>
        <name>semiquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15817</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6799728</externalid>
        <name>1,2-naphthoquinone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>34055</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58359</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29802</externalid>
        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17245</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9933538</externalid>
        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58579</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316214</externalid>
        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-5628897</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5633008</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6796648</externalid>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-3700989</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>TP53 Regulates Metabolic Genes</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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              <externalid>A0A3Q1MB49</externalid>
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          </protein>
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      <gene>
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        <name>PRDX5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q9BGI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SESN2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58CN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GSR</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DDIT4</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08E62</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>YWHAE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62261</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>COX6B2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6YFP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A140T857</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B986</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RRAGB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G5E5G3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PRKAA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBG5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330045</externalid>
        <name>PRKAG3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LL38</externalid>
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          </protein>
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        <externalid>9925920</externalid>
        <name>6-O-phosphonato-D-glucono-1,5-lactone(2-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9674665</externalid>
        <name>alpha-D-glucose 6-phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58225</externalid>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9854159</externalid>
        <name>ferroheme a(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>61715</externalid>
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      <smallmolecule>
        <externalid>1162926</externalid>
        <name>cardiolipin</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28494</externalid>
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      <smallmolecule>
        <externalid>9737455</externalid>
        <name>glutathione disulfide(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58297</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943605</externalid>
        <name>L-glutamate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29985</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9759579</externalid>
        <name>FAD(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57692</externalid>
        </xref>
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      <smallmolecule>
        <externalid>1164535</externalid>
        <name>copper(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29036</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737458</externalid>
        <name>glutathionate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57925</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9864469</externalid>
        <name>ferriheme a3(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83282</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>3299747</externalid>
        <name>copper(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49552</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114880</externalid>
        <name>ammonium</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28938</externalid>
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      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8943603</externalid>
        <name>L-glutamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      <smallmolecule>
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        <name>carbon monoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>dioxygen</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
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      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>beta-D-fructofuranose 2,6-bisphosphate(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      <smallmolecule>
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        <name>beta-D-fructofuranose 6-phosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      <linkedsystem>
        <externalid>R-HSA-5628897</externalid>
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      <linkedsystem>
        <externalid>R-BTA-3700989</externalid>
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              <externalid>Q1JQE1</externalid>
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        <name>LOC132342110</name>
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              <externalid>A0A3Q1ML53</externalid>
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              <externalid>F1MJ74</externalid>
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        <name>PIDD1</name>
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          <protein>
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              <externalid>G5E5N0</externalid>
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      <gene>
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        <name>RABGGTA</name>
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          <protein>
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              <externalid>Q5EA80</externalid>
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      <gene>
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        <name>LOC618456</name>
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          <protein>
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              <externalid>A0A3Q1MWH2</externalid>
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      <gene>
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        <name>ZNF383</name>
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          <protein>
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              <externalid>G3N009</externalid>
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        <externalid>5317197</externalid>
        <name>semiquinone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15817</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>6799728</externalid>
        <name>1,2-naphthoquinone</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>34055</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-6803211</externalid>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-6803207</externalid>
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      <linkedsystem>
        <externalid>R-BTA-6803205</externalid>
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      <linkedsystem>
        <externalid>R-HSA-5633008</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3700989</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
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    <externalid>R-BTA-6803211</externalid>
    <name>TP53 Regulates Transcription of Death Receptors and Ligands</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    </taxonomy>
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        <name>TMEM219</name>
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          </protein>
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      </gene>
      <gene>
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        <name>IGFBP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P20959</externalid>
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          </protein>
        </entity>
      </gene>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-6803204</externalid>
    <name>TP53 Regulates Transcription of Genes Involved in Cytochrome C Release</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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          </protein>
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      <gene>
        <externalid>10349958</externalid>
        <entity>
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              <externalid>E1BCC4</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5E1</externalid>
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      </gene>
      <gene>
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        <name>PRELID1</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>STEAP3</name>
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      <gene>
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      <gene>
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        <name>LOC132342110</name>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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      <gene>
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        <name>ZNF383</name>
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          <protein>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-6803204</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5633008</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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      <organism_specific_biosystem />
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <linkedsystem>
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      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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        <name>TP53I3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC75</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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              <externalid>Q5EA80</externalid>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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        <name>CDK13</name>
        <entity>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>PPP2R1A</name>
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          </protein>
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      </gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <externalid>43474</externalid>
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    </smallmolecules>
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      <linkedsystem>
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              <externalid>F6R5E4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMYD2</name>
        <entity>
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              <externalid>Q0P585</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRMT5</name>
        <entity>
          <protein>
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              <externalid>F1N443</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JMY</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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          </protein>
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      <gene>
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        <name>SETD9</name>
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              <externalid>F1MWB0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>KMT5A</name>
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              <externalid>Q2YDJ8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          </protein>
        </entity>
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      <gene>
        <externalid>10315798</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>EP300</name>
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      <gene>
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        <name>EHMT1</name>
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          <protein>
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      <gene>
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        <name>MDM2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYE6</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6804760</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5633007</externalid>
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          <superset />
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    </linkedsystems>
  </biosystem>
  <biosystem>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MHR4</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PIN1</name>
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      <gene>
        <externalid>10315820</externalid>
        <name>CHD4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N3F6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315824</externalid>
        <name>CHD3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10359299</externalid>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
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          </protein>
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      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>EP300</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10371721</externalid>
        <name>BRD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0D9</externalid>
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          </protein>
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      <gene>
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        <name>PML</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10315830</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDU9</externalid>
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          </protein>
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      <gene>
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        <name>BRPF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NAP3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ING5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBW9</externalid>
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          </protein>
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      <gene>
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        <name>RBBP7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BEB3</externalid>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>MEAF6</name>
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          <protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>GATAD2A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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          <protein>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>water</name>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163062</externalid>
        <name>acetate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30089</externalid>
        </xref>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-5633007</externalid>
        <linkedsystemtype>
          <superset />
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  </biosystem>
  <biosystem>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ING2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY31</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIP4K2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359307</externalid>
        <name>PIP4K2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349051</externalid>
        <name>PIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312572</externalid>
        <name>TP53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67939</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359299</externalid>
        <name>PIP4K2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396978</externalid>
        <name>PIP4P1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QI9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760816</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57795</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6811555</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6804758</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8864260</externalid>
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    </biosystemtype>
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      <taxnode>
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    </taxonomy>
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        <externalid>10370809</externalid>
        <name>TFAP2C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377374</externalid>
        <name>DEK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354653</externalid>
        <name>WWOX</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5N4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327818</externalid>
        <name>CGA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01217</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347417</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4Y4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403753</externalid>
        <name>ATAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400870</externalid>
        <name>KCTD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKM9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375520</externalid>
        <name>KDM5B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUR2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NPM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369766</externalid>
        <name>UBE2I</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H744</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353955</externalid>
        <name>CITED2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335866</externalid>
        <name>ESR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P49884</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400856</externalid>
        <name>CITED4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ78</externalid>
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          </protein>
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      <gene>
        <externalid>10346858</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LXL7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400860</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDI3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10346854</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10388587</externalid>
        <name>MYC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ27</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400842</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNP7</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400846</externalid>
        <name>TFAP2E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM80</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400838</externalid>
        <name>TFAP2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346862</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCL3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327824</externalid>
        <name>LHB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P04651</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>30711</externalid>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-8866907</externalid>
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      <linkedsystem>
        <externalid>R-BTA-8866910</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8869496</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8866904</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8864260</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
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  <biosystem>
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          <protein>
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              <externalid>F1MD32</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC14</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TFAP2E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM80</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4R9</externalid>
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          </protein>
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      <gene>
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        <name>CITED2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5N4</externalid>
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      </gene>
      <gene>
        <externalid>10400856</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ78</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <linkedsystem>
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      </linkedsystem>
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      <taxnode>
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      <gene>
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              <externalid>P49884</externalid>
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      <gene>
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              <externalid>P01217</externalid>
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      <gene>
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              <externalid>E1BC78</externalid>
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      <linkedsystem>
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              <externalid>Q0VC14</externalid>
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              <externalid>Q2HJ27</externalid>
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      <linkedsystem>
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      <taxnode>
        <taxid>9913</taxid>
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              <externalid>A1A4R9</externalid>
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      <gene>
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              <externalid>A0A3Q1LR94</externalid>
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      </smallmolecule>
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      <linkedsystem>
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    <externalid>R-BTA-8866904</externalid>
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      <taxnode>
        <taxid>9913</taxid>
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              <externalid>Q0VC14</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400842</externalid>
        <name>TFAP2D</name>
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          <protein>
            <xref>
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              <externalid>E1BNP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347413</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M137</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400846</externalid>
        <name>TFAP2E</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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            </xref>
          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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        <name>ESR1</name>
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          </protein>
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      <gene>
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        <name>SIN3A</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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        <name>CCNH</name>
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          </protein>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>estrogen</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      <linkedsystem>
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      <linkedsystem>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375903</externalid>
        <name>KMT2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354661</externalid>
        <name>YAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344753</externalid>
        <name>TCF3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQN2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA4</name>
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              <externalid>Q3ZCK9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNH</name>
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          </protein>
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      </gene>
      <gene>
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        <name>GATA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352934</externalid>
        <name>GATA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAM5</externalid>
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          </protein>
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      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10407255</externalid>
        <name>LMO2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI60</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GATA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR6</externalid>
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          </protein>
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      <gene>
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        <name>LMO1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5B3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>CBFB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B9S8</externalid>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
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          </protein>
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      <gene>
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          </protein>
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    </genes>
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        <name>ADP(3-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8939236</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>RUNX1 regulates transcription of genes involved in differentiation of myeloid cells</name>
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    </biosystemtype>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
        </entity>
      </gene>
    </genes>
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      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878171</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8936459</externalid>
    <name>RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8936459</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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              <externalid>G3MZR4</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>E1B896</externalid>
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          </protein>
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      <gene>
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        <name>H2B</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>G3N1G0</externalid>
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          </protein>
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      <gene>
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              <externalid>E1BPK0</externalid>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>Q5E9L5</externalid>
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          </protein>
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      <gene>
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        <name>LOC528006</name>
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              <externalid>Q0VBX4</externalid>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>A4FUE3</externalid>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>E1BDE9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>ASH2L</name>
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              <externalid>E1BEP4</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <externalid>E1BKN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>G3N3E5</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>A0A3Q1MF62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
        </entity>
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      <gene>
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              <externalid>F1MYZ3</externalid>
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          </protein>
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      <gene>
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        <name>H3-3A</name>
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              <externalid>Q5E9F8</externalid>
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          </protein>
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          </protein>
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      <gene>
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              <externalid>E1BLX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>HDAC1</name>
        <entity>
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              <externalid>Q32PJ8</externalid>
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          </protein>
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      <gene>
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              <externalid>E1BHL3</externalid>
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          </protein>
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      <gene>
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              <externalid>G3MWH4</externalid>
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          </protein>
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      <gene>
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        <name>EP300</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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              <externalid>G3MXG1</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>P62803</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
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      <gene>
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        <name>SIN3B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BGW5</externalid>
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          </protein>
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      <gene>
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        <name>SIN3A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
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          </protein>
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      <gene>
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        <name>KAT2B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLT2</externalid>
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          </protein>
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      <gene>
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              <externalid>A0A3Q1MAF6</externalid>
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          </protein>
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      <gene>
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        <name>KMT2A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MHA1</externalid>
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          </protein>
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      <gene>
        <externalid>10315685</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
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          </protein>
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              <externalid>F1MJU1</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
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          </protein>
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      <gene>
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        <name>GATA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI59</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>CBFB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B9S8</externalid>
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          </protein>
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      <gene>
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        <name>H2AZ2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7T9</externalid>
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      <gene>
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              <externalid>P62808</externalid>
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        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-8936459</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>RUNX1 regulates transcription of genes involved in BCR signaling</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
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      <gene>
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              <externalid>A0A3Q1MM48</externalid>
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          </protein>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    <name>RUNX1 regulates transcription of genes involved in interleukin signaling</name>
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      <organism_specific_biosystem />
    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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              <externalid>A0JN51</externalid>
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          </protein>
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      <gene>
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      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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        <name>ESR1</name>
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              <externalid>P49884</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>estrogen</name>
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        </xref>
      </smallmolecule>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    </biosystemtype>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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              <externalid>E1BIP8</externalid>
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      <gene>
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        <name>CTSL</name>
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              <externalid>P25975</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>Q5E968</externalid>
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      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    <biosystemtype>
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    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
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              <externalid>A0A3Q1MDR6</externalid>
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              <externalid>A0A3Q1LWF7</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>A4FUX8</externalid>
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          </protein>
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      <gene>
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        <name>CSNK2A1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P68399</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <externalid>F1MZM2</externalid>
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      <gene>
        <externalid>10370586</externalid>
        <name>SMARCB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403834</externalid>
        <name>AUTS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370768</externalid>
        <name>CBX6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KMW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370606</externalid>
        <name>ARID1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370190</externalid>
        <name>PHC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370602</externalid>
        <name>ARID1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370578</externalid>
        <name>SMARCC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370210</externalid>
        <name>CBX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370501</externalid>
        <name>HIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403842</externalid>
        <name>YAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370204</externalid>
        <name>RNF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370218</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370622</externalid>
        <name>SMARCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370618</externalid>
        <name>SMARCD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370186</externalid>
        <name>PHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHH0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346689</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370626</externalid>
        <name>ACTL6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370176</externalid>
        <name>BMI1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KX7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370172</externalid>
        <name>SCMH1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403830</externalid>
        <name>PCGF5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SMARCA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKK5</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10370610</externalid>
        <name>PBRM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LHD2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PHC3</name>
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              <externalid>A0A3Q1MBA7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SMARCD3</name>
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          <protein>
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              <externalid>Q0II51</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>A7Z019</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>F1MTG9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8939243</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878171</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8878166</externalid>
    <name>Transcriptional regulation by RUNX2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8878166</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>F1MXE4</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q5E9F9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SKP1</name>
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              <externalid>Q3ZCF3</externalid>
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          </protein>
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      <gene>
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        <name>PSMC3</name>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
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        <name>CCND1</name>
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              <externalid>A0A452DIV3</externalid>
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          </protein>
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      <gene>
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        <name>CCNB1</name>
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          <protein>
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              <externalid>Q1LZG6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMB6</name>
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              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBM14</name>
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          <protein>
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              <externalid>F1MI47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
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          <protein>
            <xref>
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              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADRM1</name>
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              <externalid>A1L5A6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q2KJ46</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA5</name>
        <entity>
          <protein>
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              <externalid>Q5E987</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P48734</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CUL1</name>
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              <externalid>F1MYD0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA6</name>
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              <externalid>Q2YDE4</externalid>
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          </protein>
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      <gene>
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        <name>PSMB3</name>
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              <externalid>P33672</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PSMC5</name>
        <entity>
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              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403161</externalid>
        <name>RUNX2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKY5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324545</externalid>
        <name>SMAD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335862</externalid>
        <name>AR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2B6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDK4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380860</externalid>
        <name>SOX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408542</externalid>
        <name>PPM1D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330226</externalid>
        <name>SMAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351720</externalid>
        <name>STUB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400928</externalid>
        <name>CBFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312031</externalid>
        <name>SKP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB09</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114844</externalid>
        <name>testosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17347</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
        <name>androst-4-ene-3,17-dione</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16422</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>157768</externalid>
        <name>6-dehydrotestosterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29117</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35313</externalid>
        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16330</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-8939902</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8941326</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-8878166</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8939902</externalid>
    <name>Regulation of RUNX2 expression and activity</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8939902</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>PSMB7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
        <externalid>244094</externalid>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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              <externalid>A4FUZ3</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>F1MLV1</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
        <externalid>244139</externalid>
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          </protein>
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      <gene>
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        <name>PSMA5</name>
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          </protein>
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      <gene>
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      <gene>
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        <name>CUL1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q3T108</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMA4</name>
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          <protein>
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              <externalid>Q3ZCK9</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PSMB3</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>STUB1</name>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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      <gene>
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        <name>PSMD8</name>
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          </protein>
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      <gene>
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        <name>PSMA7</name>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>Q2KI42</externalid>
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          </protein>
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      <gene>
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        <name>SKP2</name>
        <entity>
          <protein>
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              <externalid>A7MB09</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10403161</externalid>
        <name>RUNX2</name>
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              <externalid>A0A3Q1MKY5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>PSMD2</name>
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          <protein>
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              <externalid>P56701</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878166</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8941326</externalid>
    <name>RUNX2 regulates bone development</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8941326</url>
    <taxonomy>
      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>SMAD4</name>
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              <externalid>B0JYL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403892</externalid>
        <name>RBM14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330226</externalid>
        <name>SMAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQA2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335862</externalid>
        <name>AR</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N2B6</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10400928</externalid>
        <name>CBFB</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1B9S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403161</externalid>
        <name>RUNX2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MKY5</externalid>
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    <smallmolecules>
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        <name>testosterone</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29880</externalid>
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      <smallmolecule>
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      <smallmolecule>
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        <name>17beta-hydroxy-5alpha-androstan-3-one</name>
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    </smallmolecules>
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      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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      <smallmolecule>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8941856</externalid>
    <name>RUNX3 regulates NOTCH signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8941856</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1M7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333466</externalid>
        <name>RBPJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ41</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333476</externalid>
        <name>MAML1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333484</externalid>
        <name>MAMLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333490</externalid>
        <name>KAT2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400943</externalid>
        <name>RUNX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333494</externalid>
        <name>KAT2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333504</externalid>
        <name>SNW1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333480</externalid>
        <name>MAML2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8941856</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878159</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8951430</externalid>
    <name>RUNX3 regulates WNT signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8951430</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330701</externalid>
        <name>TCF7L2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MAN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330713</externalid>
        <name>TCF7L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400943</externalid>
        <name>RUNX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330709</externalid>
        <name>TCF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG64</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330705</externalid>
        <name>LEF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8951430</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878159</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8951671</externalid>
    <name>RUNX3 regulates YAP1-mediated transcription</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8951671</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10364136</externalid>
        <name>TEAD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400943</externalid>
        <name>RUNX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364140</externalid>
        <name>TEAD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354661</externalid>
        <name>YAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MK73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364144</externalid>
        <name>TEAD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M163</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364128</externalid>
        <name>TEAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N1G2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8951671</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878159</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8951936</externalid>
    <name>RUNX3 regulates p14-ARF</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8951936</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10334314</externalid>
        <name>HDAC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324463</externalid>
        <name>TGFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N449</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400943</externalid>
        <name>RUNX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400928</externalid>
        <name>CBFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312411</externalid>
        <name>CCND1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIV3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8951936</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8878159</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8986944</externalid>
    <name>Transcriptional Regulation by MECP2</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8986944</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>LBR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408153</externalid>
        <name>MECP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M211</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370501</externalid>
        <name>HIPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHM3</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9022692</externalid>
        <linkedsystemtype>
          <subset />
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      </linkedsystem>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-212436</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
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    <name>Regulation of MECP2 expression and activity</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
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        <name>LBR</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQV8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10408153</externalid>
        <name>MECP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M211</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340154</externalid>
        <name>SIN3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MTR3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HDAC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HIPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9022692</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8986944</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8953750</externalid>
    <name>Transcriptional Regulation by E2F6</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8953750</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10316845</externalid>
        <name>CBX3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370204</externalid>
        <name>RNF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLQ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10403412</externalid>
        <name>MAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MV00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370180</externalid>
        <name>PCGF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406882</externalid>
        <name>E2F6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DY6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370186</externalid>
        <name>PHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N4V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316224</externalid>
        <name>TAF7L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319881</externalid>
        <name>MLLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319853</externalid>
        <name>NELFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319899</externalid>
        <name>SSRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319859</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319903</externalid>
        <name>SUPT16H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316212</externalid>
        <name>TAF9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319889</externalid>
        <name>MLLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4L4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316172</externalid>
        <name>TAF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316208</externalid>
        <name>TAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316184</externalid>
        <name>TAF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319825</externalid>
        <name>CCNK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N172</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319869</externalid>
        <name>AFF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WHSC2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A6QQS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NELFCD</name>
        <entity>
          <protein>
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              <externalid>F1MW69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-674695</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73779</externalid>
    <name>RNA Polymerase II Transcription Pre-Initiation And Promoter Opening</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73779</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316244</externalid>
        <name>GTF2E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316180</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316176</externalid>
        <name>TAF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316230</externalid>
        <name>TAF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316224</externalid>
        <name>TAF7L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316192</externalid>
        <name>TAF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316240</externalid>
        <name>GTF2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316212</externalid>
        <name>TAF9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316172</externalid>
        <name>TAF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316208</externalid>
        <name>TAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316234</externalid>
        <name>TAF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316184</externalid>
        <name>TAF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316204</externalid>
        <name>TAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316164</externalid>
        <name>GTF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73779</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76042</externalid>
    <name>RNA Polymerase II Transcription Initiation And Promoter Clearance</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-76042</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316244</externalid>
        <name>GTF2E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316180</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316176</externalid>
        <name>TAF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316230</externalid>
        <name>TAF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316224</externalid>
        <name>TAF7L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316192</externalid>
        <name>TAF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316240</externalid>
        <name>GTF2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316212</externalid>
        <name>TAF9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316172</externalid>
        <name>TAF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316208</externalid>
        <name>TAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316234</externalid>
        <name>TAF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316204</externalid>
        <name>TAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316184</externalid>
        <name>TAF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316164</externalid>
        <name>GTF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-75953</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73776</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-76042</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75953</externalid>
    <name>RNA Polymerase II Transcription Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75953</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316244</externalid>
        <name>GTF2E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316180</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316176</externalid>
        <name>TAF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316230</externalid>
        <name>TAF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316224</externalid>
        <name>TAF7L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316192</externalid>
        <name>TAF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316212</externalid>
        <name>TAF9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316240</externalid>
        <name>GTF2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316172</externalid>
        <name>TAF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316208</externalid>
        <name>TAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316234</externalid>
        <name>TAF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316184</externalid>
        <name>TAF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316204</externalid>
        <name>TAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316164</externalid>
        <name>GTF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-75953</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76042</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-73776</externalid>
    <name>RNA Polymerase II Promoter Escape</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-73776</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316244</externalid>
        <name>GTF2E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316180</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316176</externalid>
        <name>TAF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316230</externalid>
        <name>TAF15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316224</externalid>
        <name>TAF7L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1E6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316192</externalid>
        <name>TAF10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316240</externalid>
        <name>GTF2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316212</externalid>
        <name>TAF9B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316172</externalid>
        <name>TAF4B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGK7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316208</externalid>
        <name>TAF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316216</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZX3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316234</externalid>
        <name>TAF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316204</externalid>
        <name>TAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316184</externalid>
        <name>TAF12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T174</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316164</externalid>
        <name>GTF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73776</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76042</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-77075</externalid>
    <name>RNA Pol II CTD phosphorylation and interaction with CE</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-77075</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317922</externalid>
        <name>RNGTT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KHX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317939</externalid>
        <name>RNMT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SUPT5H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>GTF2H5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-77075</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-75955</externalid>
    <name>RNA Polymerase II Transcription Elongation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75955</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10319821</externalid>
        <name>CDK9</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5EAB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319923</externalid>
        <name>ELOC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KII4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319833</externalid>
        <name>CCNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319965</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319829</externalid>
        <name>CCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6T8E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319927</externalid>
        <name>TCEB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319873</externalid>
        <name>EAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB75</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319895</externalid>
        <name>TCEA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RL9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319949</externalid>
        <name>PAF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317943</externalid>
        <name>SUPT5H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319945</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319955</externalid>
        <name>SKIC8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319961</externalid>
        <name>IWS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319937</externalid>
        <name>CDC73</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPQ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319877</externalid>
        <name>EAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIM2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319845</externalid>
        <name>NELFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319941</externalid>
        <name>CTR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4V2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319881</externalid>
        <name>MLLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319853</externalid>
        <name>NELFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319899</externalid>
        <name>SSRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319859</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319903</externalid>
        <name>SUPT16H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319889</externalid>
        <name>MLLT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4L4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319825</externalid>
        <name>CCNK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N172</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319869</externalid>
        <name>AFF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319841</externalid>
        <name>WHSC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319849</externalid>
        <name>NELFCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-113418</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-112382</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-75955</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-113418</externalid>
    <name>Formation of the Early Elongation Complex</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-113418</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319845</externalid>
        <name>NELFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315925</externalid>
        <name>ERCC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315945</externalid>
        <name>GTF2H1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319853</externalid>
        <name>NELFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V898</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315919</externalid>
        <name>MNAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX39</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319859</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315941</externalid>
        <name>GTF2H4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317943</externalid>
        <name>SUPT5H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315937</externalid>
        <name>GTF2H2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315933</externalid>
        <name>GTF2H3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315915</externalid>
        <name>CCNH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ML13</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315929</externalid>
        <name>ERCC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMT1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319841</externalid>
        <name>WHSC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319849</externalid>
        <name>NELFCD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MW69</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315949</externalid>
        <name>GTF2H5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737459</externalid>
        <name>nucleoside 5'-triphoshate(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61557</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-113418</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75955</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-112382</externalid>
    <name>Formation of RNA Pol II elongation complex</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-112382</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319845</externalid>
        <name>NELFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5S2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314311</externalid>
        <name>NCBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBJ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319821</externalid>
        <name>CDK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EAB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319833</externalid>
        <name>CCNT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319865</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWS0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314315</externalid>
        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLN3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10319829</externalid>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6T8E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319881</externalid>
        <name>MLLT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNI7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319853</externalid>
        <name>NELFE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
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          </protein>
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      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
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          </protein>
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      <gene>
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        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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            <xref>
              <sourcename>UniProt</sourcename>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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            <xref>
              <sourcename>UniProt</sourcename>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-112382</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75955</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    <genes>
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        <name>CPSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJD4</externalid>
            </xref>
          </protein>
        </entity>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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        <name>CLP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NCBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMM0</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>SRSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCY7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>THOC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CSTF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DHX38</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17R09</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC112442676</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LW50</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>THOC7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316956</externalid>
        <name>SNRPD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ00</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316943</externalid>
        <name>SNRPF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Z8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>WDR33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY5</externalid>
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          </protein>
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      <gene>
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        <name>U2AF1L4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>THOC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJV3</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>SRRM1</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP80</externalid>
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          </protein>
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        <name>SRSF5</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H7B7</externalid>
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          </protein>
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      <gene>
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        <name>CDC40</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBL0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ZC3H11A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKI2</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>SFRS9</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUC6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SNRPB</name>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K134</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>U2AF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ8</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>DDX39B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T147</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314608</externalid>
        <name>CASC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7H5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318096</externalid>
        <name>SLBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314458</externalid>
        <name>SRSF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q148M1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314724</externalid>
        <name>CPSF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q10568</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314632</externalid>
        <name>ALYREF</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314506</externalid>
        <name>SRSF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314780</externalid>
        <name>PCF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314750</externalid>
        <name>PABPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28165</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314768</externalid>
        <name>CPSF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314510</externalid>
        <name>SRSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T106</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314674</externalid>
        <name>CIP29</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBX1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314754</externalid>
        <name>PAPOLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25500</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314652</externalid>
        <name>THOC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N153</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314678</externalid>
        <name>DDX39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E970</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314708</externalid>
        <name>U2AF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1A4K8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314794</externalid>
        <name>CSTF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314636</externalid>
        <name>RNPS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QR16</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318118</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N038</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314764</externalid>
        <name>CPSF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314736</externalid>
        <name>CPSF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O19137</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314740</externalid>
        <name>SYMPK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314590</externalid>
        <name>SLU7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314790</externalid>
        <name>CSTF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314656</externalid>
        <name>THOC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29RH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CPSF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKB1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314612</externalid>
        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LSM10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316933</externalid>
        <entity>
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            <xref>
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              <externalid>E1BHK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314700</externalid>
        <name>FYTTD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAGOHB</name>
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          <protein>
            <xref>
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            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>POLDIP3</name>
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          <protein>
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          </protein>
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    <smallmolecules>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-73856</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <name>RNA polymerase II transcribes snRNA genes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-6807505</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q32LL5</externalid>
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          </protein>
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      <gene>
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              <externalid>Q5EAB2</externalid>
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          </protein>
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      <gene>
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        <name>NCBP2</name>
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              <externalid>Q3ZBJ1</externalid>
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          </protein>
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      <gene>
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        <name>CCNT2</name>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>ZC3H8</name>
        <entity>
          <protein>
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              <externalid>F6QNS8</externalid>
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          </protein>
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      <gene>
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        <name>GTF2E2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MUX7</externalid>
            </xref>
          </protein>
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      <gene>
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        <entity>
          <protein>
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              <externalid>A0A3Q1MA78</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>E1BF57</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NCBP1</name>
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          <protein>
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              <externalid>E1BMM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INTS7</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q1RMS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CCNT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6T8E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396916</externalid>
        <name>POU2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5B3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SNAPC4</name>
        <entity>
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              <externalid>E1BCK9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPRD2</name>
        <entity>
          <protein>
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              <externalid>E1BK49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INTS1</name>
        <entity>
          <protein>
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              <externalid>E1B8S1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2G</name>
        <entity>
          <protein>
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              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INTS11</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LT73</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2H</name>
        <entity>
          <protein>
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              <externalid>F2Z4H3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314388</externalid>
        <name>GTF2F2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397737</externalid>
        <name>SRRT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397647</externalid>
        <name>INTS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316240</externalid>
        <name>GTF2E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317943</externalid>
        <name>SUPT5H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366585</externalid>
        <name>SP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPRD1A</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q0P5J9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>INTS10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316234</externalid>
        <name>TAF8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MAZ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397659</externalid>
        <name>KIAA1698</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L552</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318381</externalid>
        <name>POU2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315911</externalid>
        <name>CDK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316164</externalid>
        <name>GTF2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397655</externalid>
        <name>INTS4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316188</externalid>
        <name>TAF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397675</externalid>
        <name>INTS9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318367</externalid>
        <name>SNAPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316158</externalid>
        <name>GTF2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316168</externalid>
        <name>TAF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319885</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLN3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397695</externalid>
        <name>ICE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS14</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314780</externalid>
        <name>PCF11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MU45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397754</externalid>
        <name>SSU72</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397671</externalid>
        <name>INTS8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJS8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327558</externalid>
        <name>PHAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316152</externalid>
        <name>GTF2A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MII0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397707</externalid>
        <name>ELL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319859</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316196</externalid>
        <name>TAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397683</externalid>
        <name>NABP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7P8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397651</externalid>
        <name>INTS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314384</externalid>
        <name>GTF2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318385</externalid>
        <name>ZNF143</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318359</externalid>
        <name>SNAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397687</externalid>
        <name>NABP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316200</externalid>
        <name>TAF9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318363</externalid>
        <name>SNAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397699</externalid>
        <name>ICE2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397627</externalid>
        <name>INTS13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318371</externalid>
        <name>SNAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29S17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319825</externalid>
        <name>CCNK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N172</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397711</externalid>
        <name>ELL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DIR8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397679</externalid>
        <name>INTS14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5EA76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396942</externalid>
        <name>RPAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9737136</externalid>
        <name>UTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46398</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737137</externalid>
        <name>CTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>35431</externalid>
        <name>7-methylguanosine 5'-phosphate(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6807505</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-73857</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-74158</externalid>
    <name>RNA Polymerase III Transcription</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-74158</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317661</externalid>
        <name>POLR3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318367</externalid>
        <name>SNAPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317665</externalid>
        <name>POLR3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317689</externalid>
        <name>POLR3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318375</externalid>
        <name>SNAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317637</externalid>
        <name>GTF3C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317669</externalid>
        <name>POLR3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317701</externalid>
        <name>POLR3GL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317679</externalid>
        <name>POLR3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317693</externalid>
        <name>POLR3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317673</externalid>
        <name>CRCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317683</externalid>
        <name>POLR3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317633</externalid>
        <name>GTF3C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318385</externalid>
        <name>ZNF143</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318393</externalid>
        <name>BRF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29S07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318359</externalid>
        <name>SNAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317649</externalid>
        <name>BRF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317621</externalid>
        <name>GTF3C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317653</externalid>
        <name>BDP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318363</externalid>
        <name>SNAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315877</externalid>
        <name>POLR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317625</externalid>
        <name>GTF3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317629</externalid>
        <name>GTF3C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M855</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318371</externalid>
        <name>SNAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29S17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318381</externalid>
        <name>POU2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317613</externalid>
        <name>GTF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317697</externalid>
        <name>POLR3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-76046</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-74158</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74160</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76046</externalid>
    <name>RNA Polymerase III Transcription Initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-76046</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317661</externalid>
        <name>POLR3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318367</externalid>
        <name>SNAPC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7J5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317665</externalid>
        <name>POLR3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317689</externalid>
        <name>POLR3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318375</externalid>
        <name>SNAPC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317637</externalid>
        <name>GTF3C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317669</externalid>
        <name>POLR3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317701</externalid>
        <name>POLR3GL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317679</externalid>
        <name>POLR3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317693</externalid>
        <name>POLR3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317673</externalid>
        <name>CRCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317683</externalid>
        <name>POLR3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317633</externalid>
        <name>GTF3C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318385</externalid>
        <name>ZNF143</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318393</externalid>
        <name>BRF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29S07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318359</externalid>
        <name>SNAPC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0I6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317649</externalid>
        <name>BRF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317621</externalid>
        <name>GTF3C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317653</externalid>
        <name>BDP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318363</externalid>
        <name>SNAPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315877</externalid>
        <name>POLR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317625</externalid>
        <name>GTF3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317629</externalid>
        <name>GTF3C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M855</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318371</externalid>
        <name>SNAPC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q29S17</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318381</externalid>
        <name>POU2F1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317613</externalid>
        <name>GTF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317697</externalid>
        <name>POLR3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-76061</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76066</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76071</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-76046</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74158</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76061</externalid>
    <name>RNA Polymerase III Transcription Initiation From Type 1 Promoter</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-76061</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317661</externalid>
        <name>POLR3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315775</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKV5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317665</externalid>
        <name>POLR3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317689</externalid>
        <name>POLR3C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317637</externalid>
        <name>GTF3C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317669</externalid>
        <name>POLR3H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1ML03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317701</externalid>
        <name>POLR3GL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317679</externalid>
        <name>POLR3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317693</externalid>
        <name>POLR3F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317673</externalid>
        <name>CRCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317683</externalid>
        <name>POLR3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317633</externalid>
        <name>GTF3C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317649</externalid>
        <name>BRF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317621</externalid>
        <name>GTF3C4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC80</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317653</externalid>
        <name>BDP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315877</externalid>
        <name>POLR1C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32L22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317625</externalid>
        <name>GTF3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0Z5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317629</externalid>
        <name>GTF3C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M855</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317613</externalid>
        <name>GTF3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUY9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317697</externalid>
        <name>POLR3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6Z7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-76061</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-76046</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-76066</externalid>
    <name>RNA Polymerase III Transcription Initiation From Type 2 Promoter</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
        <externalid>10317673</externalid>
        <name>CRCP</name>
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          <protein>
            <xref>
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        <externalid>10315775</externalid>
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      </gene>
      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKG7</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MEI8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>POLR2F</name>
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      <gene>
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        <name>POLR3D</name>
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              <externalid>A0A3Q1LQF7</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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      <gene>
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        <name>GTF3C3</name>
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          <protein>
            <xref>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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            <xref>
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          <protein>
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      <gene>
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      <linkedsystem>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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              <externalid>E1BPX6</externalid>
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      <gene>
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          <protein>
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              <externalid>E1BCK9</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2TBL4</externalid>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKG7</externalid>
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          </protein>
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      <gene>
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        <name>ZNF143</name>
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          <protein>
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              <externalid>A6QQW0</externalid>
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          </protein>
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      <gene>
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        <name>BRF2</name>
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              <externalid>Q29S07</externalid>
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          </protein>
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      <gene>
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            <xref>
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              <externalid>Q3T0I6</externalid>
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      <gene>
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      <gene>
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              <externalid>A0A3Q1M6Z7</externalid>
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      <linkedsystem>
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          <superset />
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      </linkedsystem>
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  </biosystem>
  <biosystem>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-75944</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10322978</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N2I6</externalid>
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          </protein>
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      <gene>
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        <name>POLRMT</name>
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          <protein>
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      <gene>
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            <xref>
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              <externalid>Q32LD4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TFAM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA21</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-163282</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-163316</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-75944</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-74160</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163282</externalid>
    <name>Mitochondrial transcription initiation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163282</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322962</externalid>
        <name>POLRMT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCZ0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322966</externalid>
        <name>TFB2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LD4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322956</externalid>
        <name>TFAM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BA21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-163282</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75944</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-163316</externalid>
    <name>Mitochondrial transcription termination</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-163316</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10322978</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2I6</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-75944</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-211000</externalid>
    <name>Gene Silencing by RNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-211000</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10312704</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331705</externalid>
        <name>EIF2C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312744</externalid>
        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314354</externalid>
        <name>POLR2G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314362</externalid>
        <name>POLR2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4H3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314350</externalid>
        <name>POLR2D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JQ91</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314338</externalid>
        <name>POLR2J</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341940</externalid>
        <name>TNRC6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409942</externalid>
        <name>TSN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314358</externalid>
        <name>POLR2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Q3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314374</externalid>
        <name>POLR2F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331701</externalid>
        <name>DICER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MCQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10409946</externalid>
        <name>TSNAX</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY03</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331709</externalid>
        <name>AGO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331717</externalid>
        <name>AGO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379103</externalid>
        <name>IPO8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8Q9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314378</externalid>
        <name>POLR2L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341936</externalid>
        <name>TNRC6A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N258</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314366</externalid>
        <name>POLR2K</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBC0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331713</externalid>
        <name>AGO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M249</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314321</externalid>
        <name>POLR2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZY8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314346</externalid>
        <name>POLR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341944</externalid>
        <name>TNRC6C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLT5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331725</externalid>
        <name>TARBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIG6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331697</externalid>
        <name>PRKRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2HJ92</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312660</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312750</externalid>
        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312736</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312631</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312640</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312770</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315685</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312676</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314342</externalid>
        <name>POLR2I</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ35</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331733</externalid>
        <name>RAN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T054</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315702</externalid>
        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314370</externalid>
        <name>POLR2E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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      <gene>
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      <gene>
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        <name>MBIP</name>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>MCRS1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>KAT8</name>
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          </protein>
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      </gene>
      <gene>
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        <name>POLR1A</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BIX2</externalid>
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      <gene>
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      <gene>
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      <gene>
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        <name>ZZZ3</name>
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              <externalid>A6QLC9</externalid>
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      <gene>
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        <name>ATF7IP</name>
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        <name>MED14</name>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>29644</externalid>
        <name>nicotinamide</name>
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          <sourcename>ChEBI</sourcename>
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        <externalid>9861209</externalid>
        <name>2''-O-acetyl-ADP-D-ribose(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>381312</externalid>
        <name>13(S)-HODE</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915625</externalid>
        <name>15-deoxy-Delta(12,14)-prostaglandin J2(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
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      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5221010</externalid>
        <name>5-carboxycytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76793</externalid>
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      <smallmolecule>
        <externalid>381339</externalid>
        <name>9(S)-HODE</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>34496</externalid>
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      <smallmolecule>
        <externalid>5220989</externalid>
        <name>5-formylcytosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>76794</externalid>
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      <linkedsystem>
        <externalid>R-BTA-212300</externalid>
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          <subset />
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      <linkedsystem>
        <externalid>R-BTA-5221030</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5250913</externalid>
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      <linkedsystem>
        <externalid>R-BTA-5250941</externalid>
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        <externalid>R-BTA-9842860</externalid>
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      <linkedsystem>
        <externalid>R-HSA-212165</externalid>
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      <linkedsystem>
        <externalid>R-BTA-74160</externalid>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <smallmolecule>
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        <name>S-adenosyl-L-homocysteine zwitterion</name>
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    </biosystemtype>
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    <description>computationally inferred pathway (not manually curated)</description>
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      <gene>
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        <name>WDR5</name>
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      <gene>
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      <gene>
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        <name>EP300</name>
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          </protein>
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      <gene>
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        <name>H2BC12</name>
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      <gene>
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          </protein>
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        <name>MED31</name>
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      <gene>
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          </protein>
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        <name>MED20</name>
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      <gene>
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        <name>HIST1H2BI</name>
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        <name>9-cis-retinoic acid</name>
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      <smallmolecule>
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        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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        <name>ATP(4-)</name>
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        <name>phytanate</name>
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        <externalid>R-BTA-9917777</externalid>
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    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9851695</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RXRA</name>
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        <name>RB1</name>
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        <name>LOC528006</name>
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        <name>MED27</name>
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        <name>MED1</name>
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        <name>PPARG</name>
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        <name>MED23</name>
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        <name>MED24</name>
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              <externalid>F1MUK2</externalid>
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      <gene>
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        <name>NCOR1</name>
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          <protein>
            <xref>
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        <entity>
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              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334294</externalid>
        <name>HDAC3</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N0W0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>H2BC26</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>H2AC21</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ABL1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI98</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>H3-3A</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>SIRT1</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CCNC</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>CREBBP</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>MED6</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>TBL1X</name>
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      <gene>
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              <externalid>Q3SYZ9</externalid>
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      <gene>
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        <name>EP300</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>MED31</name>
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        <name>H2AJ</name>
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              <externalid>Q3ZBX9</externalid>
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        <name>MED17</name>
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          </protein>
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              <externalid>F6RGV5</externalid>
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          </protein>
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        <name>HIST1H2BI</name>
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        <externalid>2395219</externalid>
        <name>9-cis-retinoic acid</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      <smallmolecule>
        <externalid>9762305</externalid>
        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>13(S)-HODE</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>9915625</externalid>
        <name>15-deoxy-Delta(12,14)-prostaglandin J2(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>9913874</externalid>
        <name>phytanate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37257</externalid>
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      <smallmolecule>
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        <name>9(S)-HODE</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>34496</externalid>
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      <linkedsystem>
        <externalid>R-BTA-9841922</externalid>
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      <linkedsystem>
        <externalid>R-HSA-9851695</externalid>
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          <linked />
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      <linkedsystem>
        <externalid>R-BTA-9818564</externalid>
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          <superset />
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  <biosystem>
    <externalid>R-BTA-9841922</externalid>
    <name>MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9841922</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>G3N1G0</externalid>
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        <name>GPS2</name>
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              <externalid>F1MPA7</externalid>
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      <gene>
        <externalid>10404078</externalid>
        <name>PPARGC1B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBQ2</externalid>
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          </protein>
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            <xref>
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              <externalid>G3N011</externalid>
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        <name>RXRA</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MX52</externalid>
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        <name>RB1</name>
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              <externalid>F1MD46</externalid>
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        <name>LOC528006</name>
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              <externalid>Q0VBX4</externalid>
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        <name>MED7</name>
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            <xref>
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              <externalid>F1MIJ0</externalid>
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      <gene>
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        <name>NCOA1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N0C2</externalid>
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        <name>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate</name>
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        <externalid>9915625</externalid>
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      <smallmolecule>
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              <externalid>F1MJU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312692</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312758</externalid>
        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315689</externalid>
        <name>H2AC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312740</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6T5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10375671</externalid>
        <name>ATF7IP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315702</externalid>
        <name>H2AZ2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62808</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9843970</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9842860</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1474165</externalid>
    <name>Reproduction</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1474165</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368607</externalid>
        <name>CATSPER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368629</externalid>
        <name>CATSPERD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355112</externalid>
        <name>ACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355152</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355148</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368619</externalid>
        <name>CATSPER4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355156</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355094</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417949</externalid>
        <name>DMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZM9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368615</externalid>
        <name>CATSPER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N390</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368625</externalid>
        <name>CATSPERB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368611</externalid>
        <name>CATSPER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355124</externalid>
        <name>ZP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6X7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355144</externalid>
        <name>ADAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K1H0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384695</externalid>
        <name>RAD51</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355098</externalid>
        <name>IZUMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355090</externalid>
        <name>IZUMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346136</externalid>
        <name>CD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30932</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368642</externalid>
        <name>KCNU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP59</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417893</externalid>
        <name>FIRRM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2U2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355128</externalid>
        <name>ZP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BH11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355138</externalid>
        <name>OVGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355132</externalid>
        <name>ZP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368651</externalid>
        <name>HVCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF89</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10417909</externalid>
        <name>FIGNL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355102</externalid>
        <name>IZUMO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1500620</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1187000</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1474165</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1187000</externalid>
    <name>Fertilization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1187000</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10368625</externalid>
        <name>CATSPERB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368611</externalid>
        <name>CATSPER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355124</externalid>
        <name>ZP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6X7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355144</externalid>
        <name>ADAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K1H0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368607</externalid>
        <name>CATSPER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4E7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368629</externalid>
        <name>CATSPERD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355098</externalid>
        <name>IZUMO3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QL94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355112</externalid>
        <name>ACR</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5C6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355152</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVW0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355090</externalid>
        <name>IZUMO1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355148</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346136</externalid>
        <name>CD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P30932</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368642</externalid>
        <name>KCNU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368619</externalid>
        <name>CATSPER4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355128</externalid>
        <name>ZP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BH11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355156</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355138</externalid>
        <name>OVGP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPD7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355094</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BC82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355132</externalid>
        <name>ZP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368651</externalid>
        <name>HVCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368615</externalid>
        <name>CATSPER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N390</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355102</externalid>
        <name>IZUMO4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10350924</externalid>
        <name>B4GALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08037</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1300642</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2534343</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1300645</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1187000</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1474165</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1300642</externalid>
    <name>Sperm Motility And Taxes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1300642</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>CATSPER4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZP0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368625</externalid>
        <name>CATSPERB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368611</externalid>
        <name>CATSPER2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGU6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368607</externalid>
        <name>CATSPER1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4E7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368629</externalid>
        <name>CATSPERD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368651</externalid>
        <name>HVCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF89</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368615</externalid>
        <name>CATSPER3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N390</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368642</externalid>
        <name>KCNU1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>potassium(1+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30108</externalid>
        <name>progesterone</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17026</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1300642</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1187000</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2534343</externalid>
    <name>Interaction With Cumulus Cells And The Zona Pellucida</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>ZP3</name>
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              <externalid>A6H6X7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <externalid>Q9BH11</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ADAM2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G1K1H0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10355138</externalid>
        <name>OVGP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPD7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10355156</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZT7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ZP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10355152</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVW0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368599</externalid>
        <name>LOC509761</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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          <protein>
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      <smallmolecule>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2534343</externalid>
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      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <taxnode>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>DDOST</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N632</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ACTG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B5</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTBP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340836</externalid>
        <name>NECTIN3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416059</externalid>
        <name>RPN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS82</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PARVA</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMM6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TWIST1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>HOXC8</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BI54</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PARD6A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>H2AC12</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CDH17</name>
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          </protein>
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      </gene>
      <gene>
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        <name>PRKCSH</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CADM3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q17QV6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10342929</externalid>
        <name>FLNC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV98</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10341089</externalid>
        <name>PARD6B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5R6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
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      <gene>
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        <name>CTBP1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>KIRREL3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>SPCS2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>HDAC1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CDH2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MZL1</externalid>
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          </protein>
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      <gene>
        <externalid>10312684</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FERMT2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB21</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CDH11</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADAM33</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PRKCI</name>
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              <externalid>F1MQ96</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>ACTN1</name>
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          </protein>
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      <gene>
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        <name>ARHGEF6</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>UBA52</name>
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    </genes>
    <smallmolecules>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29772</externalid>
        <name>beta-D-glucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15903</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-446728</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-391160</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373753</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1500931</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-446728</externalid>
    <name>Cell junction organization</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-446728</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>JUP</name>
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              <externalid>Q8SPJ1</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>CDH7</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BF53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SPCS3</name>
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              <externalid>Q3SZU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378047</externalid>
        <name>RACK1</name>
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          <protein>
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              <externalid>P63243</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10342917</externalid>
        <name>FBLIM1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q1JQB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340820</externalid>
        <name>CTNND1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BQ11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
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              <externalid>E1BPK0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PARVB</name>
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          <protein>
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              <externalid>A6QLQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LIMS2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ33</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333637</externalid>
        <name>ITGA6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFQ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDH10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
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            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>DDOST</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADRM1</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTG2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTBP2</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NECTIN3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPN2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PARVA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA6</name>
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          </protein>
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      </gene>
      <gene>
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        <name>TWIST1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>HOXC8</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CDH17</name>
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              <sourcename>UniProt</sourcename>
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      </gene>
      <gene>
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        <name>PRKCSH</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CADM3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>FLNC</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LV98</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PARD6B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>HDAC1</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>FERMT2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MB21</externalid>
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          </protein>
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      <gene>
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        <name>CDH11</name>
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              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ6</externalid>
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          </protein>
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      <gene>
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        <name>ADAM33</name>
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          </protein>
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      <gene>
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        <name>PRKCI</name>
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              <externalid>F1MQ96</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>UBA52</name>
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        <name>RPS27A</name>
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      <gene>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
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          <externalid>57683</externalid>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
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          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29772</externalid>
        <name>beta-D-glucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15903</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-421270</externalid>
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      <linkedsystem>
        <externalid>R-BTA-446353</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446107</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-446728</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1500931</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Cell-cell junction organization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-421270</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>JUP</name>
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              <externalid>Q8SPJ1</externalid>
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          </protein>
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      <gene>
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        <name>CDH7</name>
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              <externalid>E1BF53</externalid>
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      <gene>
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      <gene>
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              <externalid>Q3SZU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEC11A</name>
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          <protein>
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              <externalid>P67810</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RACK1</name>
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              <externalid>P63243</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC2</name>
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              <externalid>Q5E9F9</externalid>
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      <gene>
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        <name>ACTC1</name>
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              <externalid>Q3ZC07</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>POMT1</name>
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              <externalid>Q0MVC9</externalid>
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      </gene>
      <gene>
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        <name>CTNND1</name>
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              <externalid>E1BQ11</externalid>
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          </protein>
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      <gene>
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        <name>PSMC3</name>
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              <externalid>F1MWE0</externalid>
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      </gene>
      <gene>
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              <externalid>E1BPK0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ACTA1</name>
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              <externalid>P68138</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
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              <externalid>G3N011</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC528006</name>
        <entity>
          <protein>
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              <externalid>Q0VBX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340758</externalid>
        <name>CDH10</name>
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        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335631</externalid>
        <name>CDH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A5H1ZRH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDH5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZL1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335205</externalid>
        <name>SDK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPT4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341601</externalid>
        <name>SEC11C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDH11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDQ6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ADAM33</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328101</externalid>
        <name>PRKCI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ96</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RBBP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SWX8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312652</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>HIST1H2BI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4E8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
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      <gene>
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        <name>EED</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SZ25</externalid>
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          </protein>
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      <gene>
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        <name>H2AC6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4J1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD11</name>
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          <protein>
            <xref>
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              <externalid>Q2KI42</externalid>
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      <gene>
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        <name>NECTIN2</name>
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    </genes>
    <smallmolecules>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29772</externalid>
        <name>beta-D-glucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15903</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-418990</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-420029</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-373756</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-421270</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-446728</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Adherens junctions interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-418990</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>JUP</name>
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      <gene>
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      <gene>
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        <name>SEC11A</name>
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              <externalid>P67810</externalid>
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      <gene>
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        <name>RACK1</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>POMT1</name>
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      <gene>
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        <name>CTNND1</name>
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      <gene>
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              <externalid>F1MWE0</externalid>
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      <gene>
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              <externalid>E1BPK0</externalid>
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      <gene>
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              <externalid>P68138</externalid>
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          </protein>
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      <gene>
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              <externalid>G3N011</externalid>
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        <name>LOC528006</name>
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      <gene>
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        <name>CDH10</name>
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      <gene>
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      <gene>
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      <gene>
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              <externalid>E1BHE0</externalid>
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      <gene>
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        <name>CSNK2A2</name>
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              <externalid>F1MJ55</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>MDM2</name>
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              <externalid>F1MYE6</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>E1BDE9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SP1</name>
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          <protein>
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              <externalid>A0JNC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>P68432</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NECTIN1</name>
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              <externalid>F1MQJ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CDH18</name>
        <entity>
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              <externalid>Q08DJ5</externalid>
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          </protein>
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      <gene>
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        <name>DAD1</name>
        <entity>
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              <externalid>Q5E9C2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AFDN</name>
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              <externalid>A0A3Q1LN46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MTBP</name>
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              <externalid>E1BJX5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KMT5A</name>
        <entity>
          <protein>
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              <externalid>Q2YDJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC5</name>
        <entity>
          <protein>
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              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29772</externalid>
        <name>beta-D-glucose</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
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          <externalid>53019</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-420597</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9759476</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-418990</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-421270</externalid>
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  <biosystem>
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      <gene>
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      <gene>
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      <gene>
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      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-418990</externalid>
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    </linkedsystems>
  </biosystem>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343956</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406195</externalid>
        <name>PRKCSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CBLL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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        <name>ACTB</name>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CTBP1</name>
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          </protein>
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      <gene>
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        <name>MOGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7U1</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>HDAC1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SEC11C</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
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      <smallmolecule>
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        <name>zinc(2+)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
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          <externalid>53019</externalid>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>S-adenosyl-L-homocysteine zwitterion</name>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-9759476</externalid>
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    <name>Regulation of CDH1 Expression and Function</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9764265</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <name>CTNND1</name>
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      <gene>
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        <name>LOC528006</name>
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      <gene>
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      <gene>
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              <externalid>A4FUZ3</externalid>
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        <name>CSNK2A2</name>
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              <externalid>F1MJ55</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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      <gene>
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              <externalid>Q2KJ46</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9B5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10416073</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377805</externalid>
        <name>CTBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416059</externalid>
        <name>RPN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ARHGAP32</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TWIST1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N341</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322158</externalid>
        <name>FURIN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SUZ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M792</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343956</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MN97</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10406195</externalid>
        <name>PRKCSH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28034</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10371413</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CBLL1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MEB7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>49582</externalid>
        <name>ACTB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P60712</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>GANAB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZU8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CTBP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10419572</externalid>
        <name>MOGS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7U1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
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          </protein>
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      <gene>
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        <name>SPCS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEI2</externalid>
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          </protein>
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      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
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          </protein>
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      <gene>
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        <name>HDAC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMC6</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SEC11C</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KI36</externalid>
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          </protein>
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      <gene>
        <externalid>10312728</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
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          </protein>
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      <gene>
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        <name>PSMA2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
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      <gene>
        <externalid>56227</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>RBBP7</name>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>Q2KJ25</externalid>
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      <gene>
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        <name>HIST1H2BI</name>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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        <name>EED</name>
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      <gene>
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      <gene>
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        <name>RPS27A</name>
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      <gene>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <externalid>59789</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9767523</externalid>
        <name>dolichyl phosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57683</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29772</externalid>
        <name>beta-D-glucose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15903</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9940713</externalid>
        <name>dolichyl beta-D-mannosyl phosphate(1-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58211</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-9764560</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9768727</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9764561</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9764265</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9764274</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9764560</externalid>
    <name>Regulation of CDH1 Gene Transcription</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9764560</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10312704</externalid>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2B</name>
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          <protein>
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              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312754</externalid>
        <entity>
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              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312724</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415113</externalid>
        <name>DNTTIP1</name>
        <entity>
          <protein>
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              <externalid>A6H7A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
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              <externalid>E1BPK0</externalid>
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          </protein>
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      <gene>
        <externalid>10333281</externalid>
        <name>EZH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315812</externalid>
        <name>RBBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377805</externalid>
        <name>CTBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231459</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P68432</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10404099</externalid>
        <name>TWIST1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N341</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312680</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10367139</externalid>
        <name>KMT5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333285</externalid>
        <name>SUZ12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M792</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315681</externalid>
        <name>H2AC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF62</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370594</externalid>
        <name>SMARCA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>KDM1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312720</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312696</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415161</externalid>
        <name>MPHOSPH8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312635</externalid>
        <name>H2BC26</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8G9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315693</externalid>
        <name>H2AC21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341989</externalid>
        <name>SIRT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231468</externalid>
        <name>H3-3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312664</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312700</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312668</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BM22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312732</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N3L9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370165</externalid>
        <name>CTBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312712</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N080</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415101</externalid>
        <name>ZEB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N264</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315697</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MRN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312688</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315806</externalid>
        <name>HDAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315802</externalid>
        <name>HDAC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312766</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312684</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10312660</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2BC12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312728</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1R5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>385221</externalid>
        <name>H2AJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBX9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312762</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E6I9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56227</externalid>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62803</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315677</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJK3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10312640</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7N8</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MEU7</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3SWX8</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>ZMYM2</name>
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              <externalid>F1MNA8</externalid>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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              <externalid>F1MJU1</externalid>
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          </protein>
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              <externalid>E1BAA6</externalid>
            </xref>
          </protein>
        </entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MXL0</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>HIST1H2BI</name>
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          <protein>
            <xref>
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              <externalid>F2Z4E8</externalid>
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      <gene>
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        <name>EED</name>
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              <externalid>Q3SZ25</externalid>
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          </protein>
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      <gene>
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        <name>H2AC6</name>
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      <gene>
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          </protein>
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          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>S-adenosyl-L-homocysteine zwitterion</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9764265</externalid>
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      </linkedsystem>
    </linkedsystems>
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    <name>Negative Regulation of CDH1 Gene Transcription</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9764725</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MZR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312644</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B896</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>H2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32S29</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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              <externalid>A0A3Q1MBN5</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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              <externalid>G3N1G0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415113</externalid>
        <name>DNTTIP1</name>
        <entity>
          <protein>
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              <externalid>A6H7A8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312672</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPK0</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10333281</externalid>
        <name>EZH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BD02</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312708</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N011</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315673</externalid>
        <name>LOC528006</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VBX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315812</externalid>
        <name>RBBP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377805</externalid>
        <name>CTBP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCQ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>231462</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P84227</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312656</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BDE9</externalid>
            </xref>
          </protein>
        </entity>
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            </xref>
          </protein>
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      <gene>
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        <entity>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>TMEM258</name>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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    <smallmolecules>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>glycan G00008</name>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
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        <externalid>R-BTA-9764265</externalid>
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  <biosystem>
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    <name>Regulation of CDH1 Function</name>
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    <description>computationally inferred pathway (not manually curated)</description>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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      <gene>
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              <externalid>A7MBA2</externalid>
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          </protein>
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      <gene>
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          </protein>
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        <name>UBB</name>
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          </protein>
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          </protein>
        </entity>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD8</name>
        <entity>
          <protein>
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              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
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              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9766229</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9764561</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9764265</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9766229</externalid>
    <name>Degradation of CDH1</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>9860807</externalid>
        <name>SRC</name>
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          <protein>
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              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JUP</name>
        <entity>
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              <externalid>Q8SPJ1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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      <gene>
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              <externalid>F1MXE4</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10378047</externalid>
        <name>RACK1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P63243</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTNND1</name>
        <entity>
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              <externalid>E1BQ11</externalid>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTNNA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M9M0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
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              <externalid>A1L5A6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
            <xref>
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              <externalid>A5D7I1</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>UBC</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <entity>
          <protein>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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        <name>AMOT</name>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10415008</externalid>
        <name>HOXC8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI54</externalid>
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          </protein>
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      </gene>
    </genes>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9759476</externalid>
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    </linkedsystems>
  </biosystem>
  <biosystem>
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      <taxnode>
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        <name>JUP</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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            <xref>
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              <externalid>A2VDQ6</externalid>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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      <taxnode>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <linkedsystem>
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  <biosystem>
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      <linkedsystem>
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    </linkedsystems>
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      <gene>
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              <externalid>P60712</externalid>
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      <gene>
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              <externalid>A0A3Q1LV98</externalid>
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      <gene>
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      <gene>
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      <gene>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
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  <biosystem>
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      <gene>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05JF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349138</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8N5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9971693</externalid>
        <name>3',5'-cyclic GMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57746</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114841</externalid>
        <name>ethanol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16236</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9654423</externalid>
        <name>NAD(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57540</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-390522</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445355</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5576891</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-397014</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-390522</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>potassium(1+)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>NAD(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-5578775</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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              <externalid>F1MVJ8</externalid>
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      <gene>
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          </protein>
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      <gene>
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        <name>XRCC5</name>
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              <externalid>A7MBA7</externalid>
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      <gene>
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        <name>FANCM</name>
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          <protein>
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              <externalid>F1MLX2</externalid>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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          <protein>
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              <externalid>E1BIP1</externalid>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9824708</externalid>
        <name>2',3'-cyclic GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1461997</externalid>
        <name>anionic phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621617</externalid>
        <name>lipoarabinomannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850095</externalid>
        <name>1-palmitoyl-2-cis-vaccenoyl-3-alpha-D-glucosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>68524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877206</externalid>
        <name>silicon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850082</externalid>
        <name>1-O-(alpha-D-galactopyranuronosyl)-N-tetradecanoyldihydrosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>528825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395987</externalid>
        <name>c-di-GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49537</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848846</externalid>
        <name>L-idopyranose 6-monomycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6799972</externalid>
        <name>L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3134810</externalid>
        <name>cyclic purine dinucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804524</externalid>
        <name>beta-D-galactofuranosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850363</externalid>
        <name>alpha-mycolic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222751</externalid>
        <name>carbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41609</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30479</externalid>
        <name>2,5-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804520</externalid>
        <name>L-glycero-alpha-D-manno-heptopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9818553</externalid>
        <name>c-GMP-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848837</externalid>
        <name>DDM-838</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317424</externalid>
        <name>phosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28874</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621139</externalid>
        <name>trehalose 6,6'-dimycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850093</externalid>
        <name>2-O-oleoyl-3-O-palmitoyl-1-O-alpha-D-galactosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877249</externalid>
        <name>asbestos</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114961</externalid>
        <name>deoxyribonucleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789008</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850210</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33583</externalid>
        <name>2-acetamido-3-O-[(1R)-1-carboxylatoethyl]-2-deoxy-D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848838</externalid>
        <name>1-(3-O-sulfo-beta-D-galactosyl)-N-palmitoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789199</externalid>
        <name>hypochlorous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24757</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8862292</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-N(6)-(beta-D-Asp)-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55478</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9632069</externalid>
        <name>hypothiocyanous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804511</externalid>
        <name>3-deoxy-alpha-D-manno-oct-2-ulosonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788981</externalid>
        <name>N-acetyl-D-muramic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9771260</externalid>
        <name>8-hydroxy-2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850186</externalid>
        <name>3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30195</externalid>
        <name>mannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28808</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280215</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168256</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1280218</externalid>
    <name>Adaptive Immune System</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1280218</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351628</externalid>
        <name>FBXW4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9619732</externalid>
        <name>TUBB2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJB1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377950</externalid>
        <name>MAGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352467</externalid>
        <name>RACGAP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N6B9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329182</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2K2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>CD200</name>
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      <gene>
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        <name>CLTC</name>
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      <gene>
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        <name>LNX1</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CD300LB</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>PSMD12</name>
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              <externalid>Q2KJ25</externalid>
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          </protein>
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      <gene>
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        <name>HERC5</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>SEC31A</name>
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      <gene>
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              <externalid>Q3ZCC9</externalid>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58165</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621617</externalid>
        <name>lipoarabinomannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848837</externalid>
        <name>DDM-838</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850095</externalid>
        <name>1-palmitoyl-2-cis-vaccenoyl-3-alpha-D-glucosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>68524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317424</externalid>
        <name>phosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28874</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850093</externalid>
        <name>2-O-oleoyl-3-O-palmitoyl-1-O-alpha-D-galactosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850082</externalid>
        <name>1-O-(alpha-D-galactopyranuronosyl)-N-tetradecanoyldihydrosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>528825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850210</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848838</externalid>
        <name>1-(3-O-sulfo-beta-D-galactosyl)-N-palmitoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848846</externalid>
        <name>L-idopyranose 6-monomycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850363</externalid>
        <name>alpha-mycolic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850186</externalid>
        <name>3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-202403</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-388841</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983705</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983169</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2132295</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-198933</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-392517</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-8851680</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1280218</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168256</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202403</externalid>
    <name>TCR signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202403</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330930</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M088</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329092</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329114</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330914</externalid>
        <name>BOLA-DQB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N610</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330900</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330989</externalid>
        <name>ZAP70</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330924</externalid>
        <name>BoLA-DIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70IB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329100</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339549</externalid>
        <name>FYB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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            </xref>
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        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-202427</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202430</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202433</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202424</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-202403</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202427</externalid>
    <name>Phosphorylation of CD3 and TCR zeta chains</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202427</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10326081</externalid>
        <name>CSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VBZ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330930</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M088</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326149</externalid>
        <name>PAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329092</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329114</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330920</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330914</externalid>
        <name>BOLA-DQB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N610</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330900</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329132</externalid>
        <name>CD3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330884</externalid>
        <name>CD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331046</externalid>
        <name>PTPRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJS9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329128</externalid>
        <name>CD3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330942</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330892</externalid>
        <name>BOLA-DYA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330888</externalid>
        <name>BOLA-DQA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329144</externalid>
        <name>CD247</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330934</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399390</externalid>
        <name>PTPN22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330908</externalid>
        <name>BoLA-DRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q30309</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329096</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329110</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330924</externalid>
        <name>BoLA-DIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70IB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331050</externalid>
        <name>PTPRJ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6K1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329100</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330896</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202427</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202403</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202430</externalid>
    <name>Translocation of ZAP-70 to Immunological synapse</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202430</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10330930</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M088</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329092</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329114</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330920</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330914</externalid>
        <name>BOLA-DQB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N610</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330900</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329132</externalid>
        <name>CD3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330884</externalid>
        <name>CD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329128</externalid>
        <name>CD3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330989</externalid>
        <name>ZAP70</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330942</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330892</externalid>
        <name>BOLA-DYA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330888</externalid>
        <name>BOLA-DQA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329144</externalid>
        <name>CD247</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330934</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399390</externalid>
        <name>PTPN22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6L3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330908</externalid>
        <name>BoLA-DRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q30309</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329096</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329110</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330924</externalid>
        <name>BoLA-DIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70IB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329100</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330896</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202430</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202403</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202433</externalid>
    <name>Generation of second messenger molecules</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202433</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10339549</externalid>
        <name>FYB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330930</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M088</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329092</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329114</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330920</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330914</externalid>
        <name>BOLA-DQB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N610</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331133</externalid>
        <name>ITK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z039</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330900</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329132</externalid>
        <name>CD3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330884</externalid>
        <name>CD4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJK4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331142</externalid>
        <name>CD101</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329128</externalid>
        <name>CD3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330989</externalid>
        <name>ZAP70</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330942</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330892</externalid>
        <name>BOLA-DYA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330888</externalid>
        <name>BOLA-DQA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329144</externalid>
        <name>CD247</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330934</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MI49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335132</externalid>
        <name>NCK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330908</externalid>
        <name>BoLA-DRA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q30309</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329096</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329110</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330924</externalid>
        <name>BoLA-DIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q70IB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329100</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329104</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT21</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330896</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202433</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202403</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-202424</externalid>
    <name>Downstream TCR signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-202424</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330930</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M088</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329092</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MC47</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329114</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330920</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MWT2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330914</externalid>
        <name>BOLA-DQB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N610</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330900</externalid>
        <name>BOLA-DQA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0X9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331011</externalid>
        <name>TRAT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MCW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329128</externalid>
        <name>CD3E</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28073</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330938</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <name>PSMB3</name>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>PTEN</name>
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      <gene>
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          </protein>
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      <gene>
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        <name>CD3D</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>CD4</name>
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      <gene>
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        <name>LCK</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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        <name>ADP(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>114728</externalid>
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      <smallmolecule>
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        <name>diglyceride</name>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <externalid>43474</externalid>
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      </smallmolecule>
      <smallmolecule>
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          <externalid>57836</externalid>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-202424</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-202403</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-388841</externalid>
    <name>Regulation of T cell activation by CD28 family</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-388841</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>MAGT1</name>
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              <externalid>G3MY77</externalid>
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        <name>SKP1</name>
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            </xref>
          </protein>
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      <gene>
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        <name>FYN</name>
        <entity>
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              <externalid>A0JNB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PAK3</name>
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              <externalid>A0A3Q1LNA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YES1</name>
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              <externalid>A7MB57</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD8</name>
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          </protein>
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      </gene>
      <gene>
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        <name>H2AZ2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q32LA7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>56166</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312704</externalid>
        <entity>
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              <externalid>G3MZR4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SRC</name>
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      <gene>
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        <name>H2B</name>
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          </protein>
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      </gene>
      <gene>
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        <name>ICOS</name>
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          </protein>
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      </gene>
      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD6</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TUSC3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EZH2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BD02</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330920</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MWT2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>YWHAG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7Z057</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DDOST</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ADRM1</name>
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              <externalid>A1L5A6</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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      </gene>
      <gene>
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        <name>CD3E</name>
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      <gene>
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      <gene>
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      <gene>
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        <name>PPP2R5C</name>
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      </gene>
      <gene>
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        <name>PSMA1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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      <gene>
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        <name>CUL1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMA6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
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      <gene>
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        <name>BoLA-DRA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10312716</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N0F3</externalid>
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          </protein>
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      <gene>
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        <name>H2AC12</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>KMT2C</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYZ3</externalid>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B975</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <externalid>G3N3L9</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYX4</externalid>
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          </protein>
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      <gene>
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        <name>PIK3CB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>DERL1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q71SS4</externalid>
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          </protein>
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      <gene>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHL3</externalid>
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          </protein>
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      <gene>
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        <name>JAK1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1N0D6</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3MWH4</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>Q2KJ25</externalid>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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        <name>CDC42</name>
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      <gene>
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        <name>RPS27A</name>
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      <gene>
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      <gene>
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      <gene>
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    </genes>
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        <externalid>29392</externalid>
        <name>S-adenosyl-L-methionine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>59789</externalid>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
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      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
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          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>UDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>29396</externalid>
        <name>S-adenosyl-L-homocysteine zwitterion</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57856</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-389356</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9927354</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389513</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389948</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-388841</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-389356</externalid>
    <name>Co-stimulation by CD28</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-389356</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <externalid>9860807</externalid>
        <name>SRC</name>
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              <externalid>E1BIM8</externalid>
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      </gene>
      <gene>
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        <name>GRAP2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339789</externalid>
        <name>MAP3K14</name>
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              <externalid>E1BL08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321254</externalid>
        <name>PPP2R5E</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FV68</externalid>
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      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
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              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CB</name>
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          <protein>
            <xref>
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              <externalid>F1MYM3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LCK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CTLA-4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD28</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD80</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3CD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNA9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2L5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP3K8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK86</externalid>
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          </protein>
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      <gene>
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        <name>CDC42</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321238</externalid>
        <name>PPP2R5A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDZ0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>LYN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
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          </protein>
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      <gene>
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        <name>YES1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MB57</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDQ5</externalid>
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          </protein>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>GDP(3-)</name>
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      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-389357</externalid>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-389356</externalid>
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      <linkedsystem>
        <externalid>R-BTA-388841</externalid>
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    </linkedsystems>
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  <biosystem>
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              <externalid>E1BL08</externalid>
            </xref>
          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>A0A3S5ZP81</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>E1BE66</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>PIK3CB</name>
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              <externalid>F1MYM3</externalid>
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          </protein>
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      <gene>
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        <name>FYN</name>
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          <protein>
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              <externalid>A0JNB0</externalid>
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          </protein>
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      <gene>
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            <xref>
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              <externalid>E1BCV1</externalid>
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          </protein>
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      <gene>
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              <externalid>F1MQJ7</externalid>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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              <externalid>A5PK86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3R2</name>
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              <externalid>P23726</externalid>
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          </protein>
        </entity>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        <entity>
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            <xref>
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              <externalid>F1MDQ5</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MBD5</externalid>
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          </protein>
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    </genes>
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        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
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        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389356</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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    <url>http://www.reactome.org/content/detail/R-BTA-389359</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>FYN</name>
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              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339182</externalid>
        <name>PAK3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1LNA9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338813</externalid>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1MLL9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338807</externalid>
        <name>CD28</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A0A3Q1ND77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338819</externalid>
        <name>CD80</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP81</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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        <entity>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
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        <name>ADP(3-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-389359</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-389356</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <linkedsystem>
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      <gene>
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      <smallmolecule>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LL38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-9929356</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9929491</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9931269</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9931295</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9909615</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909648</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9929356</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10311799</externalid>
        <name>PSMB7</name>
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          <protein>
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              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338907</externalid>
        <name>PD-L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C5NU11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10328450</externalid>
        <name>GSK3B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
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      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>244081</externalid>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
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      <gene>
        <externalid>244139</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CUL1</name>
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          <protein>
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              <externalid>F1MYD0</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
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          </protein>
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      <gene>
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        <name>UBB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>PSMA4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      </smallmolecule>
      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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  <biosystem>
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              <externalid>F1MBI1</externalid>
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      <gene>
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          <protein>
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              <externalid>Q5E9K0</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <externalid>A0A452DIV3</externalid>
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          </protein>
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      </gene>
      <gene>
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              <externalid>Q3MHN0</externalid>
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      <gene>
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              <externalid>Q58DU5</externalid>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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              <externalid>Q32KY4</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3ZBD0</externalid>
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      <gene>
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        <name>PD-L1</name>
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            <xref>
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          </protein>
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      <gene>
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              <externalid>Q5E964</externalid>
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      <gene>
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        <name>PSMB1</name>
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      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330752</externalid>
        <name>CSNK2A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330742</externalid>
        <name>CSNK2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67868</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351922</externalid>
        <name>CUL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10381222</externalid>
        <name>SPOP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
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              <externalid>F1MYH8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA7</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>PSMD11</name>
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            <xref>
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      <gene>
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          <protein>
            <xref>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9929491</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9931269</externalid>
    <name>AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9931269</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>PSMD6</name>
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          <protein>
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              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
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          <protein>
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              <externalid>Q3MHN0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10330031</externalid>
        <name>PRKAB1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5BIS9</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>10378314</externalid>
        <name>DERL2</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F6PVF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DERL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MS86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378292</externalid>
        <name>ERLEC1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MGK3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OS9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX65</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA5</name>
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              <externalid>Q5E987</externalid>
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      <gene>
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        <name>PSMA1</name>
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              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401192</externalid>
        <name>RNF185</name>
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          <protein>
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              <externalid>A4IFC2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA6</name>
        <entity>
          <protein>
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              <externalid>Q2YDE4</externalid>
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          </protein>
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      <gene>
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        <name>PSMB3</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401202</externalid>
        <name>ERLIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0U8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401196</externalid>
        <name>RNF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0B8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401206</externalid>
        <name>ERLIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323007</externalid>
        <name>PRKAG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338907</externalid>
        <name>PD-L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C5NU11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330039</externalid>
        <name>PRKAG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P58108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378310</externalid>
        <name>SEL1L</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10398826</externalid>
        <name>DERL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q71SS4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10322999</externalid>
        <name>PRKAA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQV7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377724</externalid>
        <name>VCP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X757</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323003</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B986</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330023</externalid>
        <name>PRKAA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBG5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330045</externalid>
        <name>PRKAG3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LL38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9931269</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9931295</externalid>
    <name>PD-L1(CD274) glycosylation and translocation to plasma membrane</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9931295</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10348413</externalid>
        <name>B3GNT3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416059</externalid>
        <name>RPN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MS82</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416047</externalid>
        <name>TMEM258</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P84</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377950</externalid>
        <name>MAGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY77</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416065</externalid>
        <name>OSTC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377936</externalid>
        <name>TUSC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318254</externalid>
        <name>MIB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338899</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQR6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416053</externalid>
        <name>DAD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9C2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338903</externalid>
        <name>PDCD1LG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2W6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10419453</externalid>
        <name>STT3B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7G6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338907</externalid>
        <name>PD-L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C5NU11</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391162</externalid>
        <name>DDOST</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N632</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416043</externalid>
        <name>RPN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10416073</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8C3</externalid>
            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>STT3A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJI2</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9682876</externalid>
        <name>UDP-N-acetyl-alpha-D-glucosamine(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57705</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>449655</externalid>
        <name>glycan G00008</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737140</externalid>
        <name>UDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58223</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9931295</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909615</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983705</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10352773</externalid>
        <name>BLNK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364553</externalid>
        <name>TRPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353389</externalid>
        <name>REL</name>
        <entity>
          <protein>
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              <externalid>F1MJH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SH3KBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M839</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352799</externalid>
        <name>CD22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NI55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RASGRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5690714</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-983705</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-983695</externalid>
    <name>Antigen activates B Cell Receptor (BCR) leading to generation of second messengers</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983695</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>BLNK</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MDI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329823</externalid>
        <name>CD19</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N586</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364553</externalid>
        <name>TRPC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPA3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10410655</externalid>
        <name>DAPP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DV4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326365</externalid>
        <name>SH3KBP1</name>
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          <protein>
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              <externalid>A0A3Q1M839</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320512</externalid>
        <name>ITPR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MX21</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352799</externalid>
        <name>CD22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NI55</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD79B</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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              <externalid>A0A3Q1N7P8</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10320508</externalid>
        <name>ITPR3</name>
        <entity>
          <protein>
            <xref>
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              <externalid>E1BKE7</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <externalid>A0A3Q1M535</externalid>
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      <gene>
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              <externalid>A0A3Q1LKV0</externalid>
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          </protein>
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      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
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          <protein>
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              <externalid>Q3ZC95</externalid>
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          </protein>
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      <gene>
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        <name>STIM1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFU0</externalid>
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          </protein>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CD79A</name>
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          <protein>
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          </protein>
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      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>NCK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1LZB2</externalid>
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          </protein>
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      <gene>
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        <name>PIK3CD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BE66</externalid>
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          </protein>
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      <gene>
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        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>VAV1</name>
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          <protein>
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          </protein>
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    <smallmolecules>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-983695</externalid>
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      <linkedsystem>
        <externalid>R-BTA-983705</externalid>
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              <externalid>A1XG22</externalid>
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      <gene>
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        <name>PSMD6</name>
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          <protein>
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              <externalid>F1MXE4</externalid>
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      <gene>
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          <protein>
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              <externalid>Q5E9F9</externalid>
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      <gene>
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        <name>KRAS</name>
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          <protein>
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              <externalid>E1BMX0</externalid>
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      <gene>
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        <name>NFATC3</name>
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              <externalid>F1MSU2</externalid>
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          </protein>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
        <externalid>10314057</externalid>
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              <externalid>A0A3Q1MR28</externalid>
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          </protein>
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      <gene>
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        <name>CARD11</name>
        <entity>
          <protein>
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              <externalid>A0A3S5ZPB2</externalid>
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          </protein>
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      <gene>
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        <name>PSMB6</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>REL</name>
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          </protein>
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              <externalid>F1MBS7</externalid>
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          </protein>
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      <gene>
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              <externalid>P05126</externalid>
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              <externalid>A0A3Q1LSU3</externalid>
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          </protein>
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              <externalid>A1L5A6</externalid>
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              <externalid>A5D7R9</externalid>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <name>PSMA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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      </gene>
      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>P62194</externalid>
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        </entity>
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      <gene>
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          <protein>
            <xref>
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              <externalid>Q3ZBG0</externalid>
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          </protein>
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      <gene>
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        <name>PPP3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>IKBKB</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353441</externalid>
        <name>NFKBIE</name>
        <entity>
          <protein>
            <xref>
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              <externalid>F1MVS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363600</externalid>
        <name>NFATC1</name>
        <entity>
          <protein>
            <xref>
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              <externalid>G3XCF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331208</externalid>
        <name>BCL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323391</externalid>
        <name>FKBP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18203</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1169091</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1169092</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2025928</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1168372</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983705</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1169091</externalid>
    <name>Activation of NF-kappaB in B cells</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1169091</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353389</externalid>
        <name>REL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353441</externalid>
        <name>NFKBIE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>94037</externalid>
        <name>PRKCB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P05126</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331208</externalid>
        <name>BCL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1169091</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1168372</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1169092</externalid>
    <name>Activation of RAS in B cells</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1169092</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353427</externalid>
        <name>RASGRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1169092</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1168372</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2025928</externalid>
    <name>Calcineurin activates NFAT</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2025928</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363600</externalid>
        <name>NFATC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363589</externalid>
        <name>PPP3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323391</externalid>
        <name>FKBP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P18203</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2025928</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1168372</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5690714</externalid>
    <name>CD22 mediated BCR regulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5690714</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352718</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E513</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332486</externalid>
        <name>PTPN6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M739</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352799</externalid>
        <name>CD22</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NI55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352734</externalid>
        <name>CD79A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P40293</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352738</externalid>
        <name>CD79B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MMQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5690714</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983705</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-983169</externalid>
    <name>Class I MHC mediated antigen processing &amp; presentation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983169</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351628</externalid>
        <name>FBXW4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351746</externalid>
        <name>RNF220</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351466</externalid>
        <name>SIAH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318254</externalid>
        <name>MIB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352154</externalid>
        <name>TRIM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351940</externalid>
        <name>ASB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351516</externalid>
        <name>FBXL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331877</externalid>
        <name>SEC24B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPR4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351796</externalid>
        <name>SPSB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352250</externalid>
        <name>UBE2W</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H795</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351696</externalid>
        <name>ZNRF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351532</externalid>
        <name>FBXL14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNU6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331836</externalid>
        <name>SEC31A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMP2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10317215</externalid>
        <name>SEC13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114754</externalid>
        <name>GTP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59080</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-983168</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983170</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236975</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9912633</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-983169</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-983168</externalid>
    <name>Antigen processing: Ubiquitination &amp; Proteasome degradation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-983168</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>FBXW4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPN9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352176</externalid>
        <name>UBE2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P99</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
        <externalid>10351746</externalid>
        <name>RNF220</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351466</externalid>
        <name>SIAH1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N5G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311692</externalid>
        <name>UBE2S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RML1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312023</externalid>
        <name>SKP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCF3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352216</externalid>
        <name>UBE2L3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318254</externalid>
        <name>MIB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352154</externalid>
        <name>TRIM4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LVT3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351940</externalid>
        <name>ASB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BEH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351516</externalid>
        <name>FBXL5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351796</externalid>
        <name>SPSB4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCM1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352250</externalid>
        <name>UBE2W</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6H795</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ZNRF2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PKM1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FBXL14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNU6</externalid>
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          </protein>
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      <gene>
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        <name>HERC2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B782</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351648</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M680</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351592</externalid>
        <name>FBXO22</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351758</externalid>
        <name>TRIM11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJQ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351552</externalid>
        <name>FBXL21</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351564</externalid>
        <name>FBXO6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312035</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352054</externalid>
        <name>ARIH2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8R6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351502</externalid>
        <name>TRIM36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N3G7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351844</externalid>
        <name>KLHL20</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DK3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352200</externalid>
        <name>UBE2H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LN1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351536</externalid>
        <name>FBXL15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352114</externalid>
        <name>AREL1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N495</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351620</externalid>
        <name>FBXO2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351896</externalid>
        <name>KLHL3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBP6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351576</externalid>
        <name>FBXO10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351872</externalid>
        <name>KBTBD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N1I7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351968</externalid>
        <name>ASB15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8HXA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351636</externalid>
        <name>FBXW7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNN4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352094</externalid>
        <name>TRIM39</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7D3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352042</externalid>
        <name>PRKN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MY23</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351852</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXI0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351540</externalid>
        <name>FBXL16</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKK2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352066</externalid>
        <name>LRR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPV4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351998</externalid>
        <name>RNF7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5F4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352184</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N2X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352118</externalid>
        <name>HACE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6G5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
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      </gene>
      <gene>
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        <name>FBXO32</name>
        <entity>
          <protein>
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              <externalid>Q2KHT6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352074</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MM88</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352204</externalid>
        <name>UBE2J1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349075</externalid>
        <name>HERC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10351786</externalid>
        <name>WWP1</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
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          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114819</externalid>
        <name>magnesium(2+)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>18420</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-983168</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983169</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    </biosystemtype>
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      <taxnode>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>HSPA5</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX2</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <externalid>P01888</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10352355</externalid>
        <name>ERAP1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MU34</externalid>
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          </protein>
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      <gene>
        <externalid>10329032</externalid>
        <entity>
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          </protein>
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      <gene>
        <externalid>10329016</externalid>
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      <gene>
        <externalid>10329004</externalid>
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          </protein>
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      <gene>
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        <name>TAPBP</name>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>F1MZQ5</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10329020</externalid>
        <entity>
          <protein>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>A0A3Q1LU21</externalid>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QNT8</externalid>
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          </protein>
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      <gene>
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        <name>SEC13</name>
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          <protein>
            <xref>
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              <externalid>Q3ZCC9</externalid>
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          </protein>
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      <gene>
        <externalid>10329012</externalid>
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              <externalid>A0A3Q1MG36</externalid>
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          </protein>
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      <gene>
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        <name>BCAP31</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q5E9F1</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549022</externalid>
        <name>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-Asn residue</name>
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          <externalid>59080</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>oligopeptide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>GTP</name>
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          <externalid>15996</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
        </xref>
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      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-983170</externalid>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983169</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-1236975</externalid>
    <name>Antigen processing-Cross presentation</name>
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    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10353698</externalid>
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              <externalid>A0A452DHY1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
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      <gene>
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        <name>PSMD6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
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      <gene>
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              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>F1MWE0</externalid>
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          </protein>
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      <gene>
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              <externalid>Q3MHN0</externalid>
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          </protein>
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      <gene>
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        <entity>
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              <externalid>F1N4Y5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329016</externalid>
        <entity>
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              <externalid>A0A3Q1MIV3</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10329004</externalid>
        <entity>
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            <xref>
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              <externalid>A0A3Q1LRW6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>ITGAV</name>
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          <protein>
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              <externalid>A0A3Q1MXS2</externalid>
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          </protein>
        </entity>
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              <externalid>A4FUZ3</externalid>
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              <externalid>A1L5A6</externalid>
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      <gene>
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              <externalid>O46521</externalid>
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      <gene>
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              <externalid>Q2KJ46</externalid>
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      <gene>
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              <externalid>A0A3Q1MKI4</externalid>
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      <gene>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MWM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329028</externalid>
        <name>BoLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335794</externalid>
        <name>SNAP23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353702</externalid>
        <name>NCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329024</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354042</externalid>
        <name>CD207</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418817</externalid>
        <name>PSME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354054</externalid>
        <name>MRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335800</externalid>
        <name>VAMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244096</externalid>
        <name>PSMB9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346668</externalid>
        <name>PDIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244088</externalid>
        <name>PSMB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329008</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352372</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329020</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354046</externalid>
        <name>FCGR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333707</externalid>
        <name>ITGB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329012</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418821</externalid>
        <name>PSME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9G3</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
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      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-1236973</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236974</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236977</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236978</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1236975</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-983169</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1236973</externalid>
    <name>Cross-presentation of particulate exogenous antigens (phagosomes)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1236973</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333707</externalid>
        <name>ITGB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SQB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353706</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332818</externalid>
        <name>ITGAV</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MXS2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353688</externalid>
        <name>CYBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353702</externalid>
        <name>NCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114732</externalid>
        <name>NADPH</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114733</externalid>
        <name>NADP(+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18009</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1236973</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236975</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1236974</externalid>
    <name>ER-Phagosome pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1236974</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329024</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418817</externalid>
        <name>PSME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329016</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329004</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335800</externalid>
        <name>VAMP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244096</externalid>
        <name>PSMB9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346668</externalid>
        <name>PDIA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7E8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244088</externalid>
        <name>PSMB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329008</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244095</externalid>
        <name>PSMB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T112</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329028</externalid>
        <name>BoLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329020</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329012</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335794</externalid>
        <name>SNAP23</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2T9M8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418821</externalid>
        <name>PSME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1236974</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236975</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1236977</externalid>
    <name>Endosomal/Vacuolar pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1236977</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10329024</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329016</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIV3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329008</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329004</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LRW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10352372</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329028</externalid>
        <name>BoLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329012</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329020</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MUW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1236977</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236975</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1236978</externalid>
    <name>Cross-presentation of soluble exogenous antigens (endosomes)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1236978</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354042</externalid>
        <name>CD207</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418817</externalid>
        <name>PSME1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354054</externalid>
        <name>MRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244096</externalid>
        <name>PSMB9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZC2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244088</externalid>
        <name>PSMB10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0T1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244095</externalid>
        <name>PSMB8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T112</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354050</externalid>
        <name>MRC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354046</externalid>
        <name>FCGR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418821</externalid>
        <name>PSME2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9G3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
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      <smallmolecule>
        <externalid>1164167</externalid>
        <name>oligopeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>25676</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8942717</externalid>
        <name>L-alpha-amino acid zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59869</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1236978</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1236975</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9912633</externalid>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>PSMB7</name>
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            <xref>
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              <externalid>F1MBI1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244095</externalid>
        <name>PSMB8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T112</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <linkedsystem>
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      </linkedsystem>
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      <taxnode>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>CD74</name>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
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              <externalid>E1BPR4</externalid>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>KLC4</name>
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      <gene>
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        <name>CTSB</name>
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      <gene>
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        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
        <externalid>R-HSA-2132295</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
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    </linkedsystems>
  </biosystem>
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    <externalid>R-BTA-198933</externalid>
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    </biosystemtype>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329028</externalid>
        <name>BoLA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387972</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328973</externalid>
        <name>ITGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329626</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LT76</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387984</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400466</externalid>
        <name>NPDC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H6Y6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384749</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTX6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329186</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X7K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329841</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329790</externalid>
        <name>LOC112445051</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKD6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384831</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZR7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329178</externalid>
        <name>ULBP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZE6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329024</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI37</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKZ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329849</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E542</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329120</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MYX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384851</externalid>
        <name>KLRF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJG8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329212</externalid>
        <name>LOC112443864</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F7VJN2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387998</externalid>
        <name>TREML1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329796</externalid>
        <name>CD40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28203</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329132</externalid>
        <name>CD3D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28072</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329682</externalid>
        <name>CD200R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7V5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343210</externalid>
        <name>COL17A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>W0SK50</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384809</externalid>
        <name>SIGLEC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGL8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329008</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329829</externalid>
        <name>CD81</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329276</externalid>
        <name>ITGB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWN9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366315</externalid>
        <name>SIGLEC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BHM4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329638</externalid>
        <name>ICAM5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BLR0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387976</externalid>
        <name>CD300LB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT87</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384857</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400462</externalid>
        <name>C5H12ORF53</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329857</externalid>
        <name>LOC777594</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331581</externalid>
        <name>TREM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M8C4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332814</externalid>
        <name>TREM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329262</externalid>
        <name>KLRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10384793</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5A4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329244</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10387992</externalid>
        <name>CD300LG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7B2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329644</externalid>
        <name>ITGAL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61625</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329674</externalid>
        <name>NECTIN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MRJ9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9841058</externalid>
        <name>N-acylsphingoid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>83273</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848846</externalid>
        <name>L-idopyranose 6-monomycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42782</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316222</externalid>
        <name>3-sn-phosphatidyl-L-serine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>11750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30673</externalid>
        <name>squalene</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15440</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9762314</externalid>
        <name>ganglioside GM1(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>73110</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760791</externalid>
        <name>phosphatidylethanolamine zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57613</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850363</externalid>
        <name>alpha-mycolic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59235</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5317424</externalid>
        <name>phosphatidylinositol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28874</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850093</externalid>
        <name>2-O-oleoyl-3-O-palmitoyl-1-O-alpha-D-galactosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60453</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850082</externalid>
        <name>1-O-(alpha-D-galactopyranuronosyl)-N-tetradecanoyldihydrosphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>528825</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850210</externalid>
        <name>beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;3)-beta-D-GalNAc-(1-&gt;4)-[alpha-Neu5Ac-(2-&gt;3)]-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59228</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621617</externalid>
        <name>lipoarabinomannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848837</externalid>
        <name>DDM-838</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62384</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8848838</externalid>
        <name>1-(3-O-sulfo-beta-D-galactosyl)-N-palmitoylsphingosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60366</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850095</externalid>
        <name>1-palmitoyl-2-cis-vaccenoyl-3-alpha-D-glucosyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>68524</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765548</externalid>
        <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64716</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8850186</externalid>
        <name>3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-198933</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-392517</externalid>
    <name>Rap1 signalling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-392517</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10316907</externalid>
        <name>YWHAB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T894</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334813</externalid>
        <name>RASGRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6N9I4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339767</externalid>
        <name>SIPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPH2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>149338</externalid>
        <name>PRKG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00516</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324180</externalid>
        <name>RAP1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62833</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334732</externalid>
        <name>RAP1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61223</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334817</externalid>
        <name>RASGRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BG59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339771</externalid>
        <name>RAP1GAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339775</externalid>
        <name>RAP1GAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MBR3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316901</externalid>
        <name>YWHAZ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334112</externalid>
        <name>RAPGEF4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BPX7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319538</externalid>
        <name>PRKACA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P00517</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334118</externalid>
        <name>RAPGEF3</name>
        <entity>
          <protein>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
        <externalid>9760921</externalid>
        <name>3',5'-cyclic AMP(1-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>GTP(4-)</name>
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      <smallmolecule>
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        <name>1,2-diacyl-sn-glycerol</name>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-392517</externalid>
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          <linked />
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      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
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      </linkedsystem>
    </linkedsystems>
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  <biosystem>
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      <taxnode>
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      <gene>
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        <name>PPL</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <linkedsystem>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280218</externalid>
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          <superset />
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      <taxnode>
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      <gene>
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        <name>CFP</name>
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              <externalid>F6R2C4</externalid>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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              <externalid>E1BIP1</externalid>
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          </protein>
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    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30479</externalid>
        <name>2,5-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804520</externalid>
        <name>L-glycero-alpha-D-manno-heptopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9824708</externalid>
        <name>2',3'-cyclic GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1461997</externalid>
        <name>anionic phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9818553</externalid>
        <name>c-GMP-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621139</externalid>
        <name>trehalose 6,6'-dimycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877206</externalid>
        <name>silicon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30563</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877249</externalid>
        <name>asbestos</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114961</externalid>
        <name>deoxyribonucleic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16991</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789008</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395987</externalid>
        <name>c-di-GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49537</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33583</externalid>
        <name>2-acetamido-3-O-[(1R)-1-carboxylatoethyl]-2-deoxy-D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789199</externalid>
        <name>hypochlorous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24757</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8862292</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-N(6)-(beta-D-Asp)-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55478</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9632069</externalid>
        <name>hypothiocyanous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6799972</externalid>
        <name>L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804511</externalid>
        <name>3-deoxy-alpha-D-manno-oct-2-ulosonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3134810</externalid>
        <name>cyclic purine dinucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804524</externalid>
        <name>beta-D-galactofuranosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788981</externalid>
        <name>N-acetyl-D-muramic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222751</externalid>
        <name>carbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41609</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9771260</externalid>
        <name>8-hydroxy-2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30195</externalid>
        <name>mannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28808</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166658</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168643</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-879415</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168928</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834949</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029480</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2172127</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2454202</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5621481</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6803157</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6798695</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1222556</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9645460</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9686114</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168249</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168256</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168898</externalid>
    <name>Toll-like Receptor Cascades</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168898</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323855</externalid>
        <name>MAPK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323461</externalid>
        <name>BPI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17453</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318797</externalid>
        <name>PTPN11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N339</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316125</externalid>
        <name>FADD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q645M6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323509</externalid>
        <name>SFTPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323612</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378887</externalid>
        <name>S100A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328871</externalid>
        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323870</externalid>
        <name>JUN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324013</externalid>
        <name>NOD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6E804</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414846</externalid>
        <name>N4BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418210</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E5B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324122</externalid>
        <name>SARM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385749</externalid>
        <name>USP14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323503</externalid>
        <name>CD180</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFI2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323942</externalid>
        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401741</externalid>
        <name>TLR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323984</externalid>
        <name>S100A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359770</externalid>
        <name>TLR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339139</externalid>
        <name>MAP3K8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378883</externalid>
        <name>S100A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395308</externalid>
        <name>S100A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02639</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326833</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334332</externalid>
        <name>LGMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402191</externalid>
        <name>FGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318555</externalid>
        <name>PIK3R4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326777</externalid>
        <name>EEA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M5J6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10418225</externalid>
        <name>IRF5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344311</externalid>
        <name>IRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368687</externalid>
        <name>TIRAP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4J2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345479</externalid>
        <name>TNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357979</externalid>
        <name>CTSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9824708</externalid>
        <name>2',3'-cyclic GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9771260</externalid>
        <name>8-hydroxy-2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1679131</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168142</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168164</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168176</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168181</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168138</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166016</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181438</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5686938</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168898</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1679131</externalid>
    <name>Trafficking and processing of endosomal TLR</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1679131</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10359835</externalid>
        <name>HSP90B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95M18</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357983</externalid>
        <name>CTSL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25975</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359821</externalid>
        <name>UNC93B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBH4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359770</externalid>
        <name>TLR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334332</externalid>
        <name>LGMN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8D4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359831</externalid>
        <name>CNPY3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5N1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318561</externalid>
        <name>TLR9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5H631</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359788</externalid>
        <name>CTSB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P07688</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357979</externalid>
        <name>CTSK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E968</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPK8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357879</externalid>
        <name>CTSS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25326</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1679131</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168142</externalid>
    <name>Toll Like Receptor 10 (TLR10) Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168142</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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      <gene>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
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              <externalid>P62992</externalid>
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          </protein>
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      <gene>
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        <name>VRK3</name>
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      <gene>
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      <gene>
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        <name>S100B</name>
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          </protein>
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      <gene>
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      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>water</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>muramyl dipeptide</name>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <smallmolecule>
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        <name>peptide</name>
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      <smallmolecule>
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        <name>hydrogenphosphate</name>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-HSA-168142</externalid>
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      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
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  <biosystem>
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    <name>MyD88 cascade initiated on plasma membrane</name>
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    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        </entity>
      </gene>
      <gene>
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        <name>ALPK1</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATF1</name>
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          </protein>
        </entity>
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        <name>AGER</name>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKB1</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>bIkBa</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FOS</name>
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          <protein>
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          </protein>
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      <gene>
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        <name>MAPK7</name>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>TNIP2</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
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        <name>muramyl dipeptide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>peptide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-450294</externalid>
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      </linkedsystem>
      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-168176</externalid>
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      <linkedsystem>
        <externalid>R-BTA-168142</externalid>
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      <smallmolecule>
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      <gene>
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      <gene>
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      <gene>
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      </gene>
      <gene>
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        <name>TAB3</name>
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      </gene>
      <gene>
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        <name>MAP3K7</name>
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      <gene>
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      <smallmolecule>
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    </smallmolecules>
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        <name>RELA</name>
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      </gene>
      <gene>
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      </gene>
      <gene>
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        <name>CHUK</name>
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      <gene>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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        <name>PPP2R5D</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP4</name>
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              <externalid>F1MM08</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PPP2R1B</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JUN</name>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS6KA2</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>NOD2</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <name>DUSP7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PPP2R1A</name>
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      <gene>
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          </protein>
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      <gene>
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        <name>CREB1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>IKBKB</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>PPP2CB</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CHUK</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IRAK1</name>
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      <gene>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>NFKB1</name>
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          </protein>
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      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
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              <externalid>O77628</externalid>
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          </protein>
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      <gene>
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      <gene>
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        <name>UBA52</name>
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      <gene>
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      <gene>
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        <name>TNIP2</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
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          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
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          <externalid>59414</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-450321</externalid>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-450294</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975871</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-937061</externalid>
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      <linkedsystem>
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      <linkedsystem>
        <externalid>R-BTA-168164</externalid>
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      <linkedsystem>
        <externalid>R-BTA-448424</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166058</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-450321</externalid>
    <name>JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-450321</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>UBC</name>
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              <externalid>Q3SZJ2</externalid>
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              <externalid>Q0P5K3</externalid>
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        <name>IRAK1</name>
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              <externalid>Q2LGB3</externalid>
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          </protein>
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        <name>TAB3</name>
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          </protein>
        </entity>
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      <gene>
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        <name>MAP3K7</name>
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              <externalid>A2VDU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP2K4</name>
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        <name>UBB</name>
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              <externalid>P0CG53</externalid>
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          </protein>
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      <gene>
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        <name>UBE2V1</name>
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      <gene>
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        <name>IRAK2</name>
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              <externalid>Q0P5I2</externalid>
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              <externalid>F6QID7</externalid>
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      <gene>
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        <name>UBA52</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF6</name>
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          </protein>
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          </protein>
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      </smallmolecule>
      <smallmolecule>
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        <name>muramyl dipeptide</name>
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      </smallmolecule>
      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    </biosystemtype>
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          </protein>
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        <name>FOS</name>
        <entity>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414586</externalid>
        <name>IKBIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329902</externalid>
        <name>ATF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323961</externalid>
        <name>MAP2K4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7I1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344311</externalid>
        <name>IRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345479</externalid>
        <name>TNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328844</externalid>
        <name>RPS6KA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN61</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9013973</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445989</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450294</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168164</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9013973</externalid>
    <name>TICAM1-dependent activation of IRF3/IRF7</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9013973</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10323612</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IRF3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9013973</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168164</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168176</externalid>
    <name>Toll Like Receptor 5 (TLR5) Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168176</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
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        <name>RELA</name>
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              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349103</externalid>
        <name>NLRX1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MUU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK14</name>
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          </protein>
        </entity>
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      <gene>
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              <externalid>A0A3Q1NIT7</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>MAPK11</name>
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          <protein>
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              <externalid>G3X793</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK9</name>
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          <protein>
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              <externalid>A0A3Q1LJU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414594</externalid>
        <name>LRRC14</name>
        <entity>
          <protein>
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              <externalid>A5PJJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320032</externalid>
        <name>PPP2R1B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JUN</name>
        <entity>
          <protein>
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              <externalid>Q08DH1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNR5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NLRC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9F2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324013</externalid>
        <name>NOD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6E804</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345018</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNG1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414846</externalid>
        <name>N4BP1</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1ME40</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385749</externalid>
        <name>USP14</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q0IIF7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1M7T8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331677</externalid>
        <name>DUSP7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320028</externalid>
        <name>PPP2R1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D973</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323942</externalid>
        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CREB1</name>
        <entity>
          <protein>
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              <externalid>Q0V7N6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2V1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100A12</name>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339139</externalid>
        <name>MAP3K8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PK86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
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          <protein>
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              <externalid>F6QID7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P67774</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318222</externalid>
        <name>TRAF2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NKIRAS1</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>IKBKB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CHUK</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>IRAK1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MAP3K1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS6KA1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP3</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKBIB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ECSIT</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX05</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPKAPK2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>IKBIP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10345304</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>CASP8</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PELI1</name>
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          </protein>
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      <gene>
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        <name>UBE2N</name>
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          </protein>
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      <gene>
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        <name>ALPK1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>ATF1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>AGER</name>
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          </protein>
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      <gene>
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        <name>MAPK8</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
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          </protein>
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      </gene>
      <gene>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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        <name>UBB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>bIkBa</name>
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              <externalid>Q8WNW7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>FOS</name>
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              <externalid>O77628</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
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      <gene>
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        <name>IRAK2</name>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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      <gene>
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        <name>RPS6KA3</name>
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          <protein>
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      </gene>
      <gene>
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        <name>TNIP2</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>VRK3</name>
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      <gene>
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      <gene>
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        <name>S100B</name>
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              <externalid>P02638</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TAB2</name>
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              <externalid>E1B7Z0</externalid>
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      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975871</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168176</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168181</externalid>
    <name>Toll Like Receptor 7/8 (TLR7/8) Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168181</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <name>RELA</name>
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              <externalid>A1XG22</externalid>
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      </gene>
      <gene>
        <externalid>10323829</externalid>
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              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
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              <externalid>A0A3Q1LTT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349103</externalid>
        <name>NLRX1</name>
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          <protein>
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              <externalid>F1MUU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348081</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NIT7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323855</externalid>
        <name>MAPK9</name>
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              <externalid>A0A3Q1LJU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
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              <externalid>A2VDU3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
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          <protein>
            <xref>
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              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
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        </entity>
      </gene>
      <gene>
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        <name>RPS6KA5</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
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        <name>S100B</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>TAB2</name>
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              <externalid>E1B7Z0</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>muramyl dipeptide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-975155</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9860276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168181</externalid>
        <linkedsystemtype>
          <linked />
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
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    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-975155</externalid>
    <name>MyD88 dependent cascade initiated on endosome</name>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975155</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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        <name>TRAF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323938</externalid>
        <name>NKIRAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320022</externalid>
        <name>PPP2CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P594</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323777</externalid>
        <name>MAP3K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331669</externalid>
        <name>DUSP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323468</externalid>
        <name>CD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323787</externalid>
        <name>ECSIT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SX05</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M614</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414586</externalid>
        <name>IKBIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345304</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329902</externalid>
        <name>ATF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345308</externalid>
        <name>PELI3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323961</externalid>
        <name>MAP2K4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344311</externalid>
        <name>IRAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345479</externalid>
        <name>TNIP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328844</externalid>
        <name>RPS6KA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN61</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100B</name>
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          <protein>
            <xref>
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              <externalid>P02638</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975144</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975163</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445989</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450294</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-975138</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-975155</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-975144</externalid>
    <name>IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-975144</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345308</externalid>
        <name>PELI3</name>
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          <protein>
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              <externalid>A0A3Q1MK28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345304</externalid>
        <entity>
          <protein>
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              <externalid>Q6WCD5</externalid>
            </xref>
          </protein>
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      </gene>
      <gene>
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        <name>UBE2V1</name>
        <entity>
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          </protein>
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      </gene>
      <gene>
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        <name>S100A12</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP3K8</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>A5PK86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CA</name>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB1</name>
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              <externalid>F6QID7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF2</name>
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              <externalid>E1B9D9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NKIRAS1</name>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>PPP2CB</name>
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          </protein>
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      </gene>
      <gene>
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        <name>CHUK</name>
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          </protein>
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      </gene>
      <gene>
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        <name>IRAK1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MAP3K1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS6KA1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP3</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKB2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKBIB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD14</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QNL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKG</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ECSIT</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SX05</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PIK3C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBIP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345304</externalid>
        <entity>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNJ6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PIK3R4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A6QLW1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SLC15A4</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>MAP2K6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RIPK2</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10331681</externalid>
        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10326777</externalid>
        <name>EEA1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>CASP8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBE2N</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329902</externalid>
        <name>ATF1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PELI3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>MAP2K4</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MAPK8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
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          </protein>
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      <gene>
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        <name>IRF5</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>B0JYR2</externalid>
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          </protein>
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      <gene>
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        <name>UBB</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>NFKB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>bIkBa</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>FOS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>IRAK2</name>
        <entity>
          <protein>
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              <externalid>Q0P5I2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
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      <gene>
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        <name>RPS6KA3</name>
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          <protein>
            <xref>
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          </protein>
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      <gene>
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        <name>MAPKAPK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345479</externalid>
        <name>TNIP2</name>
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          <protein>
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              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF6</name>
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              <externalid>Q3ZCC3</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RPS27A</name>
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              <externalid>P62992</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>VRK3</name>
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          <protein>
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              <externalid>Q2YDN8</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328844</externalid>
        <name>RPS6KA5</name>
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              <externalid>E1BN61</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>S100B</name>
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              <externalid>P02638</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB2</name>
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            <xref>
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              <externalid>E1B7Z0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-975155</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9860276</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168138</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166016</externalid>
    <name>Toll Like Receptor 4 (TLR4) Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166016</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323829</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
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      </gene>
      <gene>
        <externalid>10323531</externalid>
        <name>TICAM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318226</externalid>
        <name>RIPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414634</externalid>
        <name>NLRC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9F2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345018</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MNG1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327208</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MSP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323483</externalid>
        <name>TLR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6WCD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2V1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB1</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TRAF2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NKIRAS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TBK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CHUK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327204</externalid>
        <name>DNM1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323468</externalid>
        <name>CD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10414586</externalid>
        <name>IKBIP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VE53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344311</externalid>
        <name>IRAK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368687</externalid>
        <name>TIRAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4J2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328875</externalid>
        <name>RPS6KA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TNIP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
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      <gene>
        <externalid>10331688</externalid>
        <name>VRK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
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          </protein>
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      <gene>
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        <name>TAB2</name>
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              <externalid>E1B7Z0</externalid>
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    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-166020</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166058</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166166</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166016</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166020</externalid>
    <name>Transfer of LPS from LBP carrier to CD14</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166020</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>LBP</name>
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              <externalid>F1MNN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD14</name>
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          <protein>
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              <externalid>A6QNL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
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      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-166020</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166016</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166058</externalid>
    <name>MyD88:MAL(TIRAP) cascade initiated on plasma membrane</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166058</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>RELA</name>
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          <protein>
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              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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            <xref>
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              <externalid>F1N177</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NLRX1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MUU5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK14</name>
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          <protein>
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              <externalid>A0A3Q1LTT9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348081</externalid>
        <entity>
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              <externalid>A0A3Q1NIT7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323855</externalid>
        <name>MAPK9</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJU7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321246</externalid>
        <name>PPP2R5D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N1S8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LRRC14</name>
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          <protein>
            <xref>
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              <externalid>A5PJJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331673</externalid>
        <name>DUSP4</name>
        <entity>
          <protein>
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              <externalid>F1MM08</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1B</name>
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          <protein>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>JUN</name>
        <entity>
          <protein>
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              <externalid>Q08DH1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA2</name>
        <entity>
          <protein>
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              <externalid>F1MNR5</externalid>
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          </protein>
        </entity>
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        <name>CASP8</name>
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          </protein>
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      <gene>
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        <name>UBE2N</name>
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          </protein>
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      <gene>
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        <name>ALPK1</name>
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          </protein>
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      <gene>
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        <name>ATF1</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>TNIP2</name>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>N(6)-carboxymethyl-L-lysine</name>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <smallmolecule>
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      <linkedsystem>
        <externalid>R-HSA-166166</externalid>
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      <gene>
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        <name>MAPK1</name>
        <entity>
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              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NKIRAS2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0V7N6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323483</externalid>
        <name>TLR4</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q6WCD5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324128</externalid>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100A12</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP3K8</name>
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              <externalid>A5PK86</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>TAB1</name>
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              <externalid>F6QID7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF2</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B9D9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323938</externalid>
        <name>NKIRAS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TBK1</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327973</externalid>
        <name>IRAK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324091</externalid>
        <name>UBE2D2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMX2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328867</externalid>
        <name>RPS6KA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311680</externalid>
        <name>UBE2D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA10</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331669</externalid>
        <name>DUSP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YY43</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323468</externalid>
        <name>CD14</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326735</externalid>
        <name>MAPKAPK2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBIP</name>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>MAP2K6</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>RIPK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBE2N</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329902</externalid>
        <name>ATF1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>AGER</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MAP2K4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>MAPK8</name>
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            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
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          </protein>
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      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
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            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>NFKB1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>bIkBa</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FOS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
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      <gene>
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        <name>IRAK2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>UBA52</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
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      <gene>
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        <name>RPS6KA3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SYZ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345479</externalid>
        <name>TNIP2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
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              <externalid>F1MQ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
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              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VRK3</name>
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              <externalid>Q2YDN8</externalid>
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        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
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              <externalid>C4T7Z1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328844</externalid>
        <name>RPS6KA5</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>S100B</name>
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              <externalid>P02638</externalid>
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      </gene>
      <gene>
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              <externalid>E1B7Z0</externalid>
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      </gene>
    </genes>
    <smallmolecules>
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        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-936964</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-937041</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2562578</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-937072</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-445989</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-450294</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-937061</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166166</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-936964</externalid>
    <name>Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-936964</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF3</name>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SARM1</name>
        <entity>
          <protein>
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              <externalid>E1BIR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IRF3</name>
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          <protein>
            <xref>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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      <gene>
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        <name>TANK</name>
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        <name>PTPN11</name>
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          </protein>
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      <gene>
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        <name>UBA52</name>
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          </protein>
        </entity>
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      <gene>
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        <name>CD14</name>
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              <externalid>A6QNL0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>OPTN</name>
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          <protein>
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          </protein>
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          </protein>
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      <gene>
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      </gene>
      <gene>
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          <protein>
            <xref>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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    </smallmolecules>
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      </linkedsystem>
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      <gene>
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      <gene>
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      <gene>
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      <linkedsystem>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      </smallmolecule>
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      <linkedsystem>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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          </protein>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-HSA-2562578</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-937061</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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    <externalid>R-BTA-937072</externalid>
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    </biosystemtype>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RIPK2</name>
        <entity>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TIFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345300</externalid>
        <name>PELI1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JN70</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ATF1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>AGER</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK8</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>PELI3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>MAP2K4</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKB1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328857</externalid>
        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344311</externalid>
        <name>IRAK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5I2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TIRAP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4J2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS6KA3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>TNIP2</name>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BKS3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326739</externalid>
        <name>MAPKAPK3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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        <name>TRAF6</name>
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          </protein>
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      <gene>
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        <name>RPS27A</name>
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      <gene>
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        <name>VRK3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDN8</externalid>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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      <gene>
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      <gene>
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              <externalid>E1B7Z0</externalid>
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    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
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          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-168179</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168188</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-181438</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168179</externalid>
    <name>Toll Like Receptor TLR1:TLR2 Cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168179</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RELA</name>
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      <gene>
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      <gene>
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              <externalid>A0A3Q1NIT7</externalid>
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          </protein>
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      <gene>
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        <name>MAPK11</name>
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              <externalid>G3X793</externalid>
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      <gene>
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      <gene>
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        <name>MAP3K7</name>
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              <externalid>A2VDU3</externalid>
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      <gene>
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      <gene>
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              <externalid>F1N1S8</externalid>
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      <gene>
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        <name>HMGB1</name>
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              <externalid>P10103</externalid>
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      <gene>
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        <name>LRRC14</name>
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              <externalid>A5PJJ5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP4</name>
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              <externalid>F1MM08</externalid>
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      <gene>
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        <name>PPP2R1B</name>
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              <externalid>A0A3Q1LUG0</externalid>
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          </protein>
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      <gene>
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        <name>JUN</name>
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              <externalid>Q08DH1</externalid>
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      <gene>
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        <name>RPS6KA2</name>
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              <externalid>F1MNR5</externalid>
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      <gene>
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        <name>UBC</name>
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      <gene>
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              <externalid>E1B9F2</externalid>
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      <gene>
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        <name>NOD2</name>
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              <externalid>Q6E804</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>A0A3Q1MNG1</externalid>
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          </protein>
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      <gene>
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      <gene>
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        <name>USP14</name>
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              <externalid>Q0IIF7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TAB3</name>
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              <externalid>A0A3Q1M7T8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP7</name>
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          <protein>
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              <externalid>A6QLS1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2R1A</name>
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          <protein>
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              <externalid>A5D973</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329744</externalid>
        <name>CREB1</name>
        <entity>
          <protein>
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              <externalid>Q0V7N6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323984</externalid>
        <name>S100A12</name>
        <entity>
          <protein>
            <xref>
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              <externalid>P79105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339139</externalid>
        <name>MAP3K8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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      </gene>
      <gene>
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        <name>TAB1</name>
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              <externalid>F6QID7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>61102</externalid>
        <name>PPP2CA</name>
        <entity>
          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRAF2</name>
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              <externalid>E1B9D9</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>NKIRAS1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKB</name>
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          </protein>
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      </gene>
      <gene>
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        <name>CHUK</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PPP2CB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>IRAK1</name>
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          </protein>
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      </gene>
      <gene>
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        <name>MAP3K1</name>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>DUSP3</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKB2</name>
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          </protein>
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      </gene>
      <gene>
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        <name>NFKBIB</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>IKBKG</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>ECSIT</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>IKBIP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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      </gene>
      <gene>
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      <gene>
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          </protein>
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      </gene>
      <gene>
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        <name>APP</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>DUSP6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>TIFA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>CASP8</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PELI1</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>UBE2N</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>ATF1</name>
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      <gene>
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        <name>AGER</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>bIkBa</name>
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          </protein>
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      <gene>
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        <name>FOS</name>
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      <gene>
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        <name>MAPK7</name>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>TNIP2</name>
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      <gene>
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      <gene>
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    <smallmolecules>
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        <name>ADP-L-glycero-D-manno-heptose</name>
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      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
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          <sourcename>ChEBI</sourcename>
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      </smallmolecule>
      <smallmolecule>
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        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
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          <externalid>16670</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-166058</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168179</externalid>
        <linkedsystemtype>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181438</externalid>
        <linkedsystemtype>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168188</externalid>
    <name>Toll Like Receptor TLR6:TLR2 Cascade</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168188</url>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>RELA</name>
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      <gene>
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              <externalid>F1MUU5</externalid>
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              <externalid>A0A3Q1NIT7</externalid>
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          </protein>
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        <name>MAPK11</name>
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              <externalid>G3X793</externalid>
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        <name>MAP3K7</name>
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              <externalid>A2VDU3</externalid>
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        <name>MAPK3</name>
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              <externalid>E1B8P9</externalid>
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      </gene>
      <gene>
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        <name>PPP2R5D</name>
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              <externalid>F1N1S8</externalid>
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          </protein>
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      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
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              <externalid>P10103</externalid>
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      <gene>
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        <name>LRRC14</name>
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              <externalid>A5PJJ5</externalid>
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      </gene>
      <gene>
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        <name>DUSP4</name>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-166058</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168188</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-181438</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5686938</externalid>
    <name>Regulation of TLR by endogenous ligand</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5686938</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10395308</externalid>
        <name>S100A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02639</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343300</externalid>
        <name>CD36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P26201</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323517</externalid>
        <name>SFTPD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P35246</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323483</externalid>
        <name>TLR4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6WCD5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10401741</externalid>
        <name>TLR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MV95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323455</externalid>
        <name>LBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MNN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359770</externalid>
        <name>TLR7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MK24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320164</externalid>
        <name>GSDME</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFC3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324654</externalid>
        <name>APOB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNR0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323509</externalid>
        <name>SFTPA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NJ66</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323468</externalid>
        <name>CD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QNL0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378883</externalid>
        <name>S100A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378887</externalid>
        <name>S100A9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHS5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323477</externalid>
        <name>MD-2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T7Z1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402191</externalid>
        <name>FGB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG04</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10402187</externalid>
        <name>FGA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QND5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2173614</externalid>
        <name>lysophosphatidylcholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60479</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2186965</externalid>
        <name>oxidised phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60156</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171098</externalid>
        <name>triglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17855</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>163582</externalid>
        <name>cholesteryl ester</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17002</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9824708</externalid>
        <name>2',3'-cyclic GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28181</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29974</externalid>
        <name>2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17172</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173784</externalid>
        <name>7-ketocholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64294</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173613</externalid>
        <name>hydroperoxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>64009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9771260</externalid>
        <name>8-hydroxy-2'-deoxyguanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40304</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173616</externalid>
        <name>hydroxy fatty acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24654</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>171078</externalid>
        <name>phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16247</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>30068</externalid>
        <name>guanosine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16750</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29710</externalid>
        <name>cholesterol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16113</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5686938</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168898</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
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  <biosystem>
    <externalid>R-BTA-166658</externalid>
    <name>Complement cascade</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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        <externalid>10350978</externalid>
        <name>CFH</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MP45</externalid>
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          </protein>
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      <gene>
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        <name>CD46</name>
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          <protein>
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              <externalid>A0A3Q1N570</externalid>
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          </protein>
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      <gene>
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        <name>C8B</name>
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              <externalid>F1N102</externalid>
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      <gene>
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              <externalid>Q08DZ7</externalid>
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      <gene>
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        <name>CRP</name>
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      <gene>
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              <externalid>Q3SYW2</externalid>
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      <gene>
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              <externalid>A0A3Q1M3L6</externalid>
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      <gene>
        <externalid>10324969</externalid>
        <name>C9</name>
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              <externalid>Q3MHN2</externalid>
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      <gene>
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        <name>CPN2</name>
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          </protein>
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      <gene>
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        <name>VTN</name>
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          <protein>
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              <externalid>Q3ZBS7</externalid>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
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      <gene>
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              <externalid>E1BMJ0</externalid>
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      </gene>
      <gene>
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              <externalid>G5E5V0</externalid>
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          </protein>
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      <gene>
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        <name>MBL</name>
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              <externalid>O02659</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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        <name>CFI</name>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>F1MX87</externalid>
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      <gene>
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              <externalid>Q2UVX4</externalid>
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      <gene>
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        <name>C7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LI40</externalid>
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          </protein>
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      <gene>
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        <name>LOC519737</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LSC6</externalid>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <name>MASP1</name>
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          <protein>
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              <externalid>A0A3Q1MG08</externalid>
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      <gene>
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      <gene>
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        <name>C5</name>
        <entity>
          <protein>
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              <externalid>F1MY85</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CD19</name>
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          <protein>
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              <externalid>F1N586</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>E1BH06</externalid>
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          </protein>
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      <gene>
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        <name>FCN2</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q5I2E5</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>F2</name>
        <entity>
          <protein>
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              <externalid>A0A452DI66</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357858</externalid>
        <name>ELA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323669</externalid>
        <name>MASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399506</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7W3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324847</externalid>
        <name>C1QC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3B0IZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324963</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1ME55</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325000</externalid>
        <name>CFD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324839</externalid>
        <name>C1QA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10337160</externalid>
        <name>C3AR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFF5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329829</externalid>
        <name>CD81</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331982</externalid>
        <name>CD59</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32PA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335715</externalid>
        <name>C5AR1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q673L2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399025</externalid>
        <name>CFHR5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3I2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323750</externalid>
        <name>CFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81187</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324947</externalid>
        <name>CLU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17697</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325004</externalid>
        <name>GZMM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324843</externalid>
        <name>C1QB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324859</externalid>
        <name>C1S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324855</externalid>
        <name>C1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24505</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-166663</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-174577</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166665</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-977606</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166658</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166663</externalid>
    <name>Initial triggering of complement</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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      <gene>
        <externalid>10324839</externalid>
        <name>C1QA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325000</externalid>
        <name>CFD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323691</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH06</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369498</externalid>
        <name>FCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I2E5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324882</externalid>
        <name>CRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T8B4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323687</externalid>
        <name>C2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324809</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3L6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>C3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2UVX4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ49</externalid>
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          </protein>
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      <gene>
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        <name>CFB</name>
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          <protein>
            <xref>
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              <externalid>P81187</externalid>
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          </protein>
        </entity>
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      <gene>
        <externalid>10324813</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CFP</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325004</externalid>
        <name>GZMM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324843</externalid>
        <name>C1QB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324847</externalid>
        <name>C1QC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3B0IZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399445</externalid>
        <name>COLEC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324859</externalid>
        <name>C1S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323661</externalid>
        <name>MBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02659</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
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        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-166786</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-173736</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166663</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166658</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166786</externalid>
    <name>Creation of C4 and C2 activators</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166786</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324839</externalid>
        <name>C1QA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369498</externalid>
        <name>FCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I2E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324882</externalid>
        <name>CRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T8B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324809</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323669</externalid>
        <name>MASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324813</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324843</externalid>
        <name>C1QB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324847</externalid>
        <name>C1QC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3B0IZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399445</externalid>
        <name>COLEC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324859</externalid>
        <name>C1S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323661</externalid>
        <name>MBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02659</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324855</externalid>
        <name>C1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-166662</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-173623</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166786</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166663</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166662</externalid>
    <name>Lectin pathway of complement activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166662</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10399445</externalid>
        <name>COLEC10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MLF4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369498</externalid>
        <name>FCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I2E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366750</externalid>
        <name>COLEC11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323669</externalid>
        <name>MASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323661</externalid>
        <name>MBL</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02659</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2855086</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-166662</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166786</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2855086</externalid>
    <name>Ficolins bind to repetitive carbohydrate structures on the target cell surface</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2855086</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10369498</externalid>
        <name>FCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5I2E5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323669</externalid>
        <name>MASP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJ49</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323675</externalid>
        <name>MASP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2855085</externalid>
        <name>N-acetyl-alpha-D-galactosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>40356</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2173612</externalid>
        <name>lipoteichoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28640</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>422423</externalid>
        <name>9-O-acetylneuraminic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2855086</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166662</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-173623</externalid>
    <name>Classical antibody-mediated complement activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-173623</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324839</externalid>
        <name>C1QA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9E3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324813</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324843</externalid>
        <name>C1QB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIV9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324847</externalid>
        <name>C1QC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3B0IZF8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324882</externalid>
        <name>CRP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>C4T8B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324859</externalid>
        <name>C1S</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7Q5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324809</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324855</externalid>
        <name>C1R</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D9E9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>976761</externalid>
        <name>phosphocholines</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>36700</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-173623</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166786</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-173736</externalid>
    <name>Alternative complement activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-173736</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325000</externalid>
        <name>CFD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0A3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10325004</externalid>
        <name>GZMM</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BP32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323730</externalid>
        <name>C3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2UVX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323750</externalid>
        <name>CFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81187</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-173736</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166663</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-174577</externalid>
    <name>Activation of C3 and C5</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-174577</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323695</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324912</externalid>
        <name>C5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MY85</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
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              <externalid>E1BH06</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323687</externalid>
        <name>C2</name>
        <entity>
          <protein>
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              <externalid>Q3SYW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C3</name>
        <entity>
          <protein>
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              <externalid>Q2UVX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323750</externalid>
        <name>CFB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81187</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-174577</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166658</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-166665</externalid>
    <name>Terminal pathway of complement</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-166665</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <name>C7</name>
        <entity>
          <protein>
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              <externalid>A0A3Q1LI40</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C5</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>C8B</name>
        <entity>
          <protein>
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              <externalid>F1N102</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324955</externalid>
        <name>C8A</name>
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          <protein>
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          </protein>
        </entity>
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      <gene>
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        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324969</externalid>
        <name>C9</name>
        <entity>
          <protein>
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          </protein>
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      <gene>
        <externalid>10324933</externalid>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324947</externalid>
        <name>CLU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17697</externalid>
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          </protein>
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    </genes>
    <linkedsystems>
      <linkedsystem>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-166658</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>Regulation of Complement cascade</name>
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    </biosystemtype>
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      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          <protein>
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      <gene>
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        <name>CD19</name>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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        <entity>
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      <gene>
        <externalid>10349452</externalid>
        <name>GPR77</name>
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          <protein>
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              <externalid>Q08DZ7</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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        <entity>
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      <gene>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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          <externalid>28879</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1006153</externalid>
        <name>heparins</name>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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        <name>ITCH</name>
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              <externalid>F1MGQ5</externalid>
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      <gene>
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              <externalid>Q3SZK1</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>A0A3Q1LTT9</externalid>
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          </protein>
        </entity>
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      <gene>
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              <externalid>G3X793</externalid>
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          </protein>
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      <gene>
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        <name>MAPK13</name>
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              <externalid>Q5E9Q6</externalid>
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      </gene>
      <gene>
        <externalid>10344691</externalid>
        <name>MAPK12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354546</externalid>
        <name>TXNIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z054</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347447</externalid>
        <name>PSTPIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324013</externalid>
        <name>NOD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6E804</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347433</externalid>
        <name>PYCARD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318279</externalid>
        <name>CYLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347378</externalid>
        <name>NLRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347231</externalid>
        <name>NLRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347427</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320549</externalid>
        <name>P2RX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335662</externalid>
        <name>PANX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7R519</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347382</externalid>
        <name>SUGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877249</externalid>
        <name>asbestos</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877206</externalid>
        <name>silicon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30563</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-168638</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622312</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168643</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168638</externalid>
    <name>NOD1/2 Signaling Pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168638</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10347028</externalid>
        <name>ITCH</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGQ5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326072</externalid>
        <name>AAMP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZK1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323843</externalid>
        <name>MAPK14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LTT9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323837</externalid>
        <name>MAPK11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X793</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354430</externalid>
        <name>MAPK13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9Q6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344691</externalid>
        <name>MAPK12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PJL3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324021</externalid>
        <name>RIPK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SZJ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324013</externalid>
        <name>NOD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q6E804</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318269</externalid>
        <name>BIRC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3SYW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318265</externalid>
        <name>BIRC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3X822</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318279</externalid>
        <name>CYLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-168638</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168643</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-622312</externalid>
    <name>Inflammasomes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-622312</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347433</externalid>
        <name>PYCARD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347378</externalid>
        <name>NLRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347231</externalid>
        <name>NLRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354546</externalid>
        <name>TXNIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z054</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347447</externalid>
        <name>PSTPIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347427</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320549</externalid>
        <name>P2RX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335662</externalid>
        <name>PANX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7R519</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347382</externalid>
        <name>SUGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877249</externalid>
        <name>asbestos</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877206</externalid>
        <name>silicon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30563</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-844456</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-844455</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-622312</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168643</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-844456</externalid>
    <name>The NLRP3 inflammasome</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-844456</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10347447</externalid>
        <name>PSTPIP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347427</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2Q8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347433</externalid>
        <name>PYCARD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315634</externalid>
        <name>TXN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97680</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320549</externalid>
        <name>P2RX7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVZ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347378</externalid>
        <name>NLRP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLE5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335662</externalid>
        <name>PANX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>D7R519</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347382</externalid>
        <name>SUGT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KIK0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354546</externalid>
        <name>TXNIP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z054</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>877249</externalid>
        <name>asbestos</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>46661</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1236635</externalid>
        <name>reactive oxygen species</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>26523</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114810</externalid>
        <name>potassium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29103</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9954179</externalid>
        <name>hyaluronate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>132153</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>877206</externalid>
        <name>silicon dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30563</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-844456</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622312</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-844455</externalid>
    <name>The NLRP1 inflammasome</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-844455</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10320188</externalid>
        <name>BCL2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6R2C4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346478</externalid>
        <name>BCL2L1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05KJ0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347231</externalid>
        <name>NLRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNN6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-844455</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-622312</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-879415</externalid>
    <name>Advanced glycosylation endproduct receptor signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-879415</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347463</externalid>
        <name>CAPZA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E997</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323984</externalid>
        <name>S100A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347459</externalid>
        <name>CAPZA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-879415</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-168928</externalid>
    <name>DDX58/IFIH1-mediated induction of interferon-alpha/beta</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-168928</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10349051</externalid>
        <name>PIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349276</externalid>
        <name>TAX1BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349103</externalid>
        <name>NLRX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MUU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376387</externalid>
        <name>TOMM70A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E34</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330824</externalid>
        <name>HSP90AA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NKI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349083</externalid>
        <name>UBE2L6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10341032</externalid>
        <name>HSP90AB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q76LV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323612</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349079</externalid>
        <name>ISG15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02741</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318279</externalid>
        <name>CYLD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMU2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323942</externalid>
        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349087</externalid>
        <name>UBA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6Q4D3</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323984</externalid>
        <name>S100A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349075</externalid>
        <name>HERC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318308</externalid>
        <name>IKBKE</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQ36</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323938</externalid>
        <name>NKIRAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZM4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349099</externalid>
        <name>MAVS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MIH6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349064</externalid>
        <name>RIGI</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-918233</externalid>
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          <subset />
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-933542</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-936440</externalid>
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          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-168928</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-918233</externalid>
    <name>TRAF3-dependent IRF activation pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-918233</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
    <genes>
      <gene>
        <externalid>10323612</externalid>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-918233</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168928</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-933541</externalid>
    <name>TRAF6 mediated IRF7 activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-933541</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323612</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-933541</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168928</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-933542</externalid>
    <name>TRAF6 mediated NF-kB activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-933542</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324000</externalid>
        <name>APP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUG2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323980</externalid>
        <name>AGER</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N306</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323942</externalid>
        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323984</externalid>
        <name>S100A12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79105</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323996</externalid>
        <name>HMGB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P10103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323938</externalid>
        <name>NKIRAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZM4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323990</externalid>
        <name>S100B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P02638</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-933542</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168928</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-936440</externalid>
    <name>Negative regulators of DDX58/IFIH1 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-936440</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349051</externalid>
        <name>PIN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5BIN5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349276</externalid>
        <name>TAX1BP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349079</externalid>
        <name>ISG15</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02741</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NLRX1</name>
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              <externalid>F1MUU5</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CYLD</name>
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          <protein>
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              <externalid>Q1RMU2</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IRF3</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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        <name>HERC5</name>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAVS</name>
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      <gene>
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      </gene>
      <gene>
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          </protein>
        </entity>
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    </genes>
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      <linkedsystem>
        <externalid>R-HSA-936440</externalid>
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          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168928</externalid>
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          <superset />
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    </linkedsystems>
  </biosystem>
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    </biosystemtype>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CHUK</name>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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        <name>MRE11</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIN9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      </gene>
      <gene>
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        <name>TRIM21</name>
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          </protein>
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      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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      <gene>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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        <name>cyclic purine dinucleotide</name>
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      <smallmolecule>
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        <name>deoxyribonucleic acid</name>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        <name>ATP(4-)</name>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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      <linkedsystem>
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        <linkedsystemtype>
          <subset />
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      <linkedsystem>
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      <linkedsystem>
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    <taxonomy>
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              <externalid>A1XG22</externalid>
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          </protein>
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      <gene>
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        <name>DHX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28141</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>IRF3</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
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          </protein>
        </entity>
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      <gene>
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        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
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      <gene>
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        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
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              <externalid>Q8WNW7</externalid>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
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      <gene>
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          <protein>
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          </protein>
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      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NKIRAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZM4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKB</name>
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          <protein>
            <xref>
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              <externalid>Q95KV0</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
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        <name>ADP(3-)</name>
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          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1810476</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1606322</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834949</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1606341</externalid>
    <name>IRF3 mediated activation of type 1 IFN</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1606341</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1606341</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1606322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1810476</externalid>
    <name>RIP-mediated NFkB activation via ZBP1</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1810476</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370347</externalid>
        <name>DHX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28141</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323901</externalid>
        <name>NFKBIB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323938</externalid>
        <name>NKIRAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZM4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323942</externalid>
        <name>NKIRAS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-1810476</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1606322</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1834941</externalid>
    <name>STING mediated induction of host immune responses</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1834941</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360932</externalid>
        <name>STING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338006</externalid>
        <name>STAT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360726</externalid>
        <name>DTX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370326</externalid>
        <name>DDX41</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3KN07</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9818553</externalid>
        <name>c-GMP-AMP(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>71501</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>3134810</externalid>
        <name>cyclic purine dinucleotide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>47037</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2395987</externalid>
        <name>c-di-GMP</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>49537</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-3270619</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-3249367</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1834941</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834949</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3270619</externalid>
    <name>IRF3-mediated induction of type I IFN</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3270619</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360932</externalid>
        <name>STING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360726</externalid>
        <name>DTX4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MFB5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3270619</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834941</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3249367</externalid>
    <name>STAT6-mediated induction of chemokines</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3249367</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10360932</externalid>
        <name>STING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10338006</externalid>
        <name>STAT6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318315</externalid>
        <name>TBK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKP4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3249367</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834941</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3134973</externalid>
    <name>LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3134973</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10333500</externalid>
        <name>CREBBP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MD32</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328470</externalid>
        <name>CTNNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349008</externalid>
        <name>EP300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8D6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323608</externalid>
        <name>IRF3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q4JF28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3134973</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834949</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3134963</externalid>
    <name>DEx/H-box helicases activate type I IFN and inflammatory cytokines production</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3134963</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370347</externalid>
        <name>DHX9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28141</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328017</externalid>
        <name>MYD88</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHW6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323612</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MWF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10370341</externalid>
        <name>DHX36</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B79</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-3134963</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1834949</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-3134975</externalid>
    <name>Regulation of innate immune responses to cytosolic DNA</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-3134975</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360932</externalid>
        <name>STING1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI99</externalid>
            </xref>
          </protein>
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      </gene>
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        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-2029481</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029482</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029485</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2029480</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2029481</externalid>
    <name>FCGR activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2029481</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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    </taxonomy>
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        <externalid>10324813</externalid>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
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          </protein>
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      </gene>
      <gene>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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          </protein>
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      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
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          <protein>
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              <externalid>G8JL01</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>10324809</externalid>
        <entity>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>FCGR2B</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHH9</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2029481</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029480</externalid>
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          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2029482</externalid>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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              <externalid>Q0IIJ3</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
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              <externalid>F1MIX6</externalid>
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          </protein>
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      </gene>
      <gene>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BN47</externalid>
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          </protein>
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      <gene>
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        <entity>
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          </protein>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>A8YXX8</externalid>
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          </protein>
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      <gene>
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      <gene>
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              <externalid>F1MX60</externalid>
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          </protein>
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      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
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              <externalid>Q3T0F9</externalid>
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          </protein>
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      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>WASL</name>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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        <name>PAK1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>VAV3</name>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
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      <gene>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3MHR7</externalid>
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          </protein>
        </entity>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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        </entity>
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      <gene>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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        </entity>
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          </protein>
        </entity>
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      <gene>
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            </xref>
          </protein>
        </entity>
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      <gene>
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          <protein>
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            </xref>
          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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          </protein>
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          </protein>
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            <xref>
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          </protein>
        </entity>
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      <gene>
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          </protein>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326445</externalid>
        <name>CDC42</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363956</externalid>
        <name>WASF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDK6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2029482</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029480</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2029485</externalid>
    <name>Role of phospholipids in phagocytosis</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2029485</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357101</externalid>
        <name>PLD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFP5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364059</externalid>
        <name>PLPP5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH11</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364055</externalid>
        <name>PLPP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXQ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324809</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M3L6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360428</externalid>
        <name>FCGR2B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHH9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324813</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N0V0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324805</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10354046</externalid>
        <name>FCGR1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357105</externalid>
        <name>PLD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MFB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10364075</externalid>
        <name>PLD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329138</externalid>
        <name>CD3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G8JL01</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10360301</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJY0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356914</externalid>
        <name>PLA2G6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BB89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9796686</externalid>
        <name>phosphatidate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57739</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9765528</externalid>
        <name>1,2-diacyl-sn-glycero-3-phosphocholine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>549074</externalid>
        <name>1,2-diacyl-sn-glycerol</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17815</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760788</externalid>
        <name>arachidonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32395</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114975</externalid>
        <name>1-O-acyl-sn-glycero-3-phosphocholine(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17504</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>264633</externalid>
        <name>choline</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15354</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2029485</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2029480</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2172127</externalid>
    <name>DAP12 interactions</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2172127</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10366343</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3R3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366321</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366331</externalid>
        <name>KLRC1-4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A2Z2AM52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366325</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4Y9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366347</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3R3B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366335</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366359</externalid>
        <name>NKG2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366339</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NM98</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366351</externalid>
        <name>KLRC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366355</externalid>
        <name>LOC513869</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHY4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332814</externalid>
        <name>TREM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329262</externalid>
        <name>KLRK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2424491</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2172127</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2424491</externalid>
    <name>DAP12 signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2424491</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10366343</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3R3B4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328998</externalid>
        <name>B2M</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P01888</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366321</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T8B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366331</externalid>
        <name>KLRC1-4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A2Z2AM52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366325</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N4Y9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366347</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A3R3B5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366335</externalid>
        <name>NKG2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7L0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330879</externalid>
        <name>LCK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366359</externalid>
        <name>NKG2C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MPK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10328994</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MU93</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366339</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NM98</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320339</externalid>
        <name>FYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366351</externalid>
        <name>KLRC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A8E4Q0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC513869</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHY4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TREM2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q05B59</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10329262</externalid>
        <name>KLRK1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MI53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2424491</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2172127</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2454202</externalid>
    <name>Fc epsilon receptor (FCERI) signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2454202</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323855</externalid>
        <name>MAPK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323870</externalid>
        <name>JUN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369086</externalid>
        <name>TXK</name>
        <entity>
          <protein>
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        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368038</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N342</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-2871796</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2871809</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2871837</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2730905</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-2454202</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2871796</externalid>
    <name>FCERI mediated MAPK activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2871796</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324620</externalid>
        <name>KRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323855</externalid>
        <name>MAPK9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LJU7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323777</externalid>
        <name>MAP3K1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B847</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315748</externalid>
        <name>MAPK3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B8P9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320331</externalid>
        <name>FCER1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323870</externalid>
        <name>JUN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339176</externalid>
        <name>PAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M0G8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339170</externalid>
        <name>PAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08E52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324626</externalid>
        <name>NRAS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5D7R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368038</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N342</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368028</externalid>
        <name>FCER1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318901</externalid>
        <name>MAPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P46196</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323961</externalid>
        <name>MAP2K4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N7I1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320632</externalid>
        <name>MAPK8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345006</externalid>
        <name>FOS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O77628</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324632</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MXH2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2871796</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2454202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2871809</externalid>
    <name>FCERI mediated Ca+2 mobilization</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2871809</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10331059</externalid>
        <name>GRAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10332508</externalid>
        <name>TEC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSH3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331133</externalid>
        <name>ITK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7Z039</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363600</externalid>
        <name>NFATC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331065</externalid>
        <name>LCP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DS6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320331</externalid>
        <name>FCER1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369086</externalid>
        <name>TXK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MF99</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340881</externalid>
        <name>VAV3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BBD2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368038</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N342</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353320</externalid>
        <name>BTK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZC95</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363589</externalid>
        <name>PPP3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368028</externalid>
        <name>FCER1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331024</externalid>
        <name>LAT</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZ60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340877</externalid>
        <name>VAV2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339028</externalid>
        <name>VAV1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q08DN7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2871809</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2454202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2871837</externalid>
    <name>FCERI mediated NF-kB activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2871837</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
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        <name>RELA</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324797</externalid>
        <entity>
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              <externalid>A0A3Q1LKV0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368028</externalid>
        <name>FCER1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330457</externalid>
        <name>PRKCQ</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMG4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62194</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244087</externalid>
        <name>PSMA7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323929</externalid>
        <name>IKBKB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>99101</externalid>
        <name>PSMD2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323919</externalid>
        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331208</externalid>
        <name>BCL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320331</externalid>
        <name>FCER1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368038</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N342</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2871837</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2454202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-2730905</externalid>
    <name>Role of LAT2/NTAL/LAB on calcium mobilization</name>
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      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-2730905</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10324797</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368038</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3N342</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10369121</externalid>
        <name>LAT2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368028</externalid>
        <name>FCER1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QQQ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318829</externalid>
        <name>GAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M864</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316703</externalid>
        <name>PIK3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23727</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316693</externalid>
        <name>SOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N7C3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316689</externalid>
        <name>GRB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316717</externalid>
        <name>PIK3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYM3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316729</externalid>
        <name>SHC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0IIE2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316707</externalid>
        <name>PIK3R2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P23726</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368032</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BNU1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320343</externalid>
        <name>LYN</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N261</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320468</externalid>
        <name>SYK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHG9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316713</externalid>
        <name>PIK3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P32871</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320331</externalid>
        <name>FCER1G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9BDR7</externalid>
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          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-2730905</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-2454202</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
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    <name>C-type lectin receptors (CLRs)</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5621481</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10380103</externalid>
        <name>CLEC4D</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4H1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10400424</externalid>
        <name>CLEC10A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BJL5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379334</externalid>
        <name>CARD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RIH1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348178</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LQ52</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10348158</externalid>
        <name>MUC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M633</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
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      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5621139</externalid>
        <name>trehalose 6,6'-dimycolate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>82624</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735744</externalid>
        <name>coenzyme A(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57287</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735742</externalid>
        <name>acetyl-CoA(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57288</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30195</externalid>
        <name>mannan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28808</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5607764</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5621480</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5621575</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5621481</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5607764</externalid>
    <name>CLEC7A (Dectin-1) signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5607764</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
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        <externalid>9860807</externalid>
        <name>SRC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIM8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323881</externalid>
        <name>RELA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1XG22</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320449</externalid>
        <name>PLCG2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4C7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10319649</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZX0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331178</externalid>
        <name>CARD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZPB2</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379334</externalid>
        <name>CARD9</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RIH1</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331215</externalid>
        <name>MALT1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBS7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>RELB</name>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MBB0</externalid>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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          </protein>
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      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PYCARD</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQF6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363589</externalid>
        <name>PPP3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H703</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
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          </protein>
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      <gene>
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        <name>PSMA6</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324109</externalid>
        <name>UBE2V1</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ78</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>99054</externalid>
        <name>PSMB3</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P33672</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
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          <protein>
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              <externalid>P62194</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>TAB1</name>
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          <protein>
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              <externalid>F6QID7</externalid>
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          </protein>
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      <gene>
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        <name>PSMA7</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBG0</externalid>
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          </protein>
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      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
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          </protein>
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      <gene>
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        <name>IKBKB</name>
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          <protein>
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              <externalid>Q95KV0</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD2</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>P56701</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB2</name>
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              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
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              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>MAP3K14</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>E1BL08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFATC1</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>G3XCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD7</name>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318863</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MQJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IKBKG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>CLEC7A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N2F3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>BCL10</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QJ6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316131</externalid>
        <name>CASP8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2LGB8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10312821</externalid>
        <name>UBE2N</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0P5K3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323885</externalid>
        <name>NFKB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MKW9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323897</externalid>
        <name>bIkBa</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8WNW7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311743</externalid>
        <name>PSMD8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYH8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>202393</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16152</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760815</externalid>
        <name>1D-myo-inositol 1,4,5-trisphosphate(6-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>203600</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>174723</externalid>
        <name>diglyceride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58456</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760856</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57836</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1163952</externalid>
        <name>(1-&gt;3)-beta-D-glucan</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37671</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-5607763</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5607761</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5660668</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-5607764</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5621481</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5607763</externalid>
    <name>CLEC7A (Dectin-1) induces NFAT activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5607763</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10363633</externalid>
        <name>NFATC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MGR9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363600</externalid>
        <name>NFATC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3XCF6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363616</externalid>
        <name>NFATC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSU2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10363589</externalid>
        <name>PPP3CB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6H703</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10314057</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MR28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>51294</externalid>
        <name>PPP3R1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63099</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>97574</externalid>
        <name>PPP3CA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P48452</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-5607763</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5607764</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-5607761</externalid>
    <name>Dectin-1 mediated noncanonical NF-kB signaling</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-5607761</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311799</externalid>
        <name>PSMB7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBI1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244092</externalid>
        <name>PSMB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9K0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311769</externalid>
        <name>PSMD6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MXE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244067</externalid>
        <name>PSMC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9F9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323923</externalid>
        <name>CHUK</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95KV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311723</externalid>
        <name>PSMC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MWE0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10339789</externalid>
        <name>MAP3K14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BL08</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244094</externalid>
        <name>PSMB6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3MHN0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244082</externalid>
        <name>PSMA3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356312</externalid>
        <name>PSMD7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZBD0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323889</externalid>
        <name>NFKB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244104</externalid>
        <name>PSMD13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E964</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311783</externalid>
        <name>PSMB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G5E589</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918601</externalid>
        <name>PSMC1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4FUZ3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>356304</externalid>
        <name>PSMB5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KL2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>218119</externalid>
        <name>ADRM1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A1L5A6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311727</externalid>
        <name>PSMC6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLV1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10379276</externalid>
        <name>RELB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MBB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>9918619</externalid>
        <name>PSMD14</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q17QP9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244081</externalid>
        <name>PSMA2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0Y5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244139</externalid>
        <name>PSMD3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ46</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244084</externalid>
        <name>PSMA5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E987</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244080</externalid>
        <name>PSMA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T0X5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244085</externalid>
        <name>PSMA6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2YDE4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244093</externalid>
        <name>PSMB4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T108</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311703</externalid>
        <name>PSMD1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244083</externalid>
        <name>PSMA4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCK9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMB3</name>
        <entity>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>62234</externalid>
        <name>PSMC5</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
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            </xref>
          </protein>
        </entity>
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      <gene>
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        <name>UBA52</name>
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          <protein>
            <xref>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244066</externalid>
        <name>PSMC4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3T030</externalid>
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          </protein>
        </entity>
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      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD8</name>
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          <protein>
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              <externalid>F1MYH8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMA7</name>
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          <protein>
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          </protein>
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      </gene>
      <gene>
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        <name>PSMD11</name>
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          <protein>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>PSMD2</name>
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          </protein>
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    </genes>
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      </smallmolecule>
      <smallmolecule>
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        <name>ATP(4-)</name>
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    </smallmolecules>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-5607764</externalid>
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          <superset />
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
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      <gene>
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        <name>PYCARD</name>
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          <protein>
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      <gene>
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      <gene>
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    </genes>
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          <linked />
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      </linkedsystem>
      <linkedsystem>
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    <name>Dectin-2 family</name>
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              <externalid>E1BHM0</externalid>
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      <gene>
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      <gene>
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      <gene>
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      <smallmolecule>
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      <smallmolecule>
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      <taxnode>
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      <smallmolecule>
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      </smallmolecule>
      <smallmolecule>
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      <smallmolecule>
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        </xref>
      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
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          </protein>
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      <gene>
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          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>F1MI67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343348</externalid>
        <name>SLC11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356288</externalid>
        <name>LOC112444619</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10378883</externalid>
        <name>S100A8</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P28782</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395489</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LX31</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391778</externalid>
        <name>LYS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80189</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356248</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MT20</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397019</externalid>
        <name>SPINLW1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32KP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391088</externalid>
        <name>S100A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28050</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356256</externalid>
        <name>defb300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q50JB9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356252</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25068</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356268</externalid>
        <name>DEFB119</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393756</externalid>
        <name>PGLYRP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BH94</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396108</externalid>
        <name>BPIFA1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPU5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391080</externalid>
        <name>LOC786350</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LGT8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10397476</externalid>
        <name>LEAP2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95JC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10357858</externalid>
        <name>ELA2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPP7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356818</externalid>
        <name>PLA2G2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q56JZ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394550</externalid>
        <name>REG3G</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356296</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LNK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356356</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394605</externalid>
        <name>RNASE6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P08904</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10335041</externalid>
        <name>CCR6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MT56</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356284</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUH5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389949</externalid>
        <name>PGLYRP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q8SPP7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394601</externalid>
        <name>ARHGEF40</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MZA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356272</externalid>
        <name>DEFB121</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356460</externalid>
        <name>PRSS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7YWU9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396112</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MHQ2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10393742</externalid>
        <name>PGLYRP4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MPE3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356280</externalid>
        <name>DEFB124</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7LMA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356276</externalid>
        <name>DEFB123</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RSW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391084</externalid>
        <name>S100A7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BKA1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10324947</externalid>
        <name>CLU</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P17697</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396116</externalid>
        <name>LOC112441508</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RMF1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10396122</externalid>
        <name>BPIFB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLW2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10334955</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3S5ZP45</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10394609</externalid>
        <name>LOC783267</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1N0V6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10395351</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LWA5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10377243</externalid>
        <name>LCN2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B6Z6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>30479</externalid>
        <name>2,5-dihydroxybenzoic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6799972</externalid>
        <name>L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>61626</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804511</externalid>
        <name>3-deoxy-alpha-D-manno-oct-2-ulosonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>85986</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804524</externalid>
        <name>beta-D-galactofuranosyl group</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59496</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>31621</externalid>
        <name>sodium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114768</externalid>
        <name>calcium(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29108</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789008</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55424</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6804520</externalid>
        <name>L-glycero-alpha-D-manno-heptopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>42976</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788981</externalid>
        <name>N-acetyl-D-muramic acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>21615</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1461997</externalid>
        <name>anionic phospholipid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>62643</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29618</externalid>
        <name>aldehydo-N-acetyl-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17411</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1222751</externalid>
        <name>carbonate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>41609</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>33583</externalid>
        <name>2-acetamido-3-O-[(1R)-1-carboxylatoethyl]-2-deoxy-D-glucopyranose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28881</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>917869</externalid>
        <name>iron(3+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29034</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2855128</externalid>
        <name>N-acetyl-beta-D-glucosamine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>28009</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8862292</externalid>
        <name>beta-GlcNAc-(1-&gt;4)-MurNAc-L-Ala-gamma-D-Glu-N(6)-(beta-D-Asp)-L-Lys-(D-Ala)2</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55478</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-1461973</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6799990</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-6803544</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-6803157</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1461973</externalid>
    <name>Defensins</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1461973</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10356256</externalid>
        <name>defb300</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q50JB9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356272</externalid>
        <name>DEFB121</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MVX4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356260</externalid>
        <name>DEFB113</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MG60</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356252</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P25068</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356268</externalid>
        <name>DEFB119</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32P86</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356280</externalid>
        <name>DEFB124</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7LMA0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356276</externalid>
        <name>DEFB123</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6RSW1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356264</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LMI6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356356</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LLP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356288</externalid>
        <name>LOC112444619</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LKM9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10356296</externalid>
        <entity>
          <protein>
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            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323760</externalid>
        <name>CFP</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M2R9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244103</externalid>
        <name>PSMD12</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJ25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392862</externalid>
        <name>DNAJC3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N036</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10366862</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LUM6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10315977</externalid>
        <name>IMPDH1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0JNA3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10358317</externalid>
        <name>GM2A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BI28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391726</externalid>
        <name>OLFM4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MVJ8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10391178</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N4X8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10327007</externalid>
        <name>ALAD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q58DK5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10385132</externalid>
        <name>XRCC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A7MBA7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320525</externalid>
        <name>P2RX1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BIP1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-6798695</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-1222556</externalid>
    <name>ROS and RNS production in phagocytes</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-1222556</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10353698</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DHY1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316546</externalid>
        <name>ATP6V0D1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P61420</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316550</externalid>
        <name>ATP6V0D2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KJB6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316604</externalid>
        <name>ATP6V1E2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q32LB7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340600</externalid>
        <name>NOS2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYR5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316538</externalid>
        <name>ATP6V0C</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DJ67</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316600</externalid>
        <name>ATP6V1E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P11019</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316590</externalid>
        <name>ATP6V1C2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFJ9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316610</externalid>
        <name>ATP6V1F</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q28029</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316512</externalid>
        <name>ATP6V0A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MH43</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320208</externalid>
        <name>RAC2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU25</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316530</externalid>
        <name>ATP6V0B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TA24</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316524</externalid>
        <name>TCIRG1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1RMS1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353688</externalid>
        <name>CYBA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46521</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316630</externalid>
        <name>ATP6V1H</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46563</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353692</externalid>
        <name>CYBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O46522</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316568</externalid>
        <name>ATP6V1A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31404</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389934</externalid>
        <name>MPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353706</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MKI4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316618</externalid>
        <name>ATP6V1G2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VCV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316586</externalid>
        <name>ATP6V1C1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P21282</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316556</externalid>
        <name>ATP6V0E1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P81103</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10340594</externalid>
        <name>NOS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M6M2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316578</externalid>
        <name>ATP6V1B2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31408</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10343348</externalid>
        <name>SLC11A1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJ63</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316534</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NBC9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10368651</externalid>
        <name>HVCN1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1NF89</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316516</externalid>
        <name>ATP6V0A2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O97681</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316596</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M4W9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316520</externalid>
        <name>ATP6V0A4</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BGJ7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316622</externalid>
        <name>ATP6V1G3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMV6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316574</externalid>
        <name>ATP6V1B1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P31407</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316560</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A452DI38</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399972</externalid>
        <name>LPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80025</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10330800</externalid>
        <name>NOS3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LSD1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353702</externalid>
        <name>NCF2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MTW8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10316614</externalid>
        <name>ATP6V1G1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P79251</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9632069</externalid>
        <name>hypothiocyanous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737452</externalid>
        <name>NADPH(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57783</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316220</externalid>
        <name>manganese(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29035</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760817</externalid>
        <name>L-citrulline zwitterion</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57743</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8943581</externalid>
        <name>L-argininium(1+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>32682</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30317</externalid>
        <name>nitric oxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16480</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114734</externalid>
        <name>dioxygen</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15379</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9737451</externalid>
        <name>NADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58349</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>30601</externalid>
        <name>superoxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18421</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>5316186</externalid>
        <name>iron(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29033</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789199</externalid>
        <name>hypochlorous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24757</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-8941413</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1222556</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-8941413</externalid>
    <name>Events associated with phagocytolytic activity of PMN cells</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-8941413</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10389934</externalid>
        <name>MPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QPT4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10399972</externalid>
        <name>LPO</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P80025</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>9632069</externalid>
        <name>hypothiocyanous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>133907</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>29518</externalid>
        <name>nitrite</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16301</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8855486</externalid>
        <name>thiocyanate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>18022</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1500754</externalid>
        <name>nitrogen dioxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33101</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6788990</externalid>
        <name>ferriheme b(1-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>55376</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114781</externalid>
        <name>chloride</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17996</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6789199</externalid>
        <name>hypochlorous acid</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>24757</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-8941413</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1222556</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9645460</externalid>
    <name>Alpha-protein kinase 1 signaling pathway</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9645460</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10311592</externalid>
        <name>UBC</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CH28</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411768</externalid>
        <name>TIFA</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDM0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10411762</externalid>
        <name>ALPK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BMC1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344351</externalid>
        <name>TAB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F6QID7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344357</externalid>
        <name>TAB3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1M7T8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331258</externalid>
        <name>MAP3K7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A2VDU3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311576</externalid>
        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10331254</externalid>
        <name>TAB2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9645460</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9686114</externalid>
    <name>Non-canonical inflammasome activation</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9686114</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344619</externalid>
        <name>IL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392410</externalid>
        <name>SERPINB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420288</externalid>
        <name>LOC132342100</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420271</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420262</externalid>
        <name>LOC507055</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420266</externalid>
        <name>GBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-9948001</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9960519</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9948011</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9960525</externalid>
        <linkedsystemtype>
          <subset />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-9686114</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168249</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9948001</externalid>
    <name>CASP4 inflammasome assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9948001</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420288</externalid>
        <name>LOC132342100</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392410</externalid>
        <name>SERPINB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q1JPB0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420271</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1B7Z4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420262</externalid>
        <name>LOC507055</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BAL7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420266</externalid>
        <name>GBP1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MHZ1</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9948001</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9686114</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9960519</externalid>
    <name>CASP4-mediated substrate cleavage</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9960519</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344619</externalid>
        <name>IL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
        <name>CASP3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MB04</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344036</externalid>
        <name>IL1B</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A140T838</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9960519</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9686114</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9948011</externalid>
    <name>CASP5 inflammasome assembly</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9948011</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-HSA-9948011</externalid>
        <linkedsystemtype>
          <linked />
        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9686114</externalid>
        <linkedsystemtype>
          <superset />
        </linkedsystemtype>
      </linkedsystem>
    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-9960525</externalid>
    <name>CASP5-mediated substrate cleavage</name>
    <biosystemtype>
      <organism_specific_biosystem />
    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-9960525</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
      </taxnode>
    </taxonomy>
    <genes>
      <gene>
        <externalid>10344619</externalid>
        <name>IL18</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q9TU73</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320158</externalid>
        <name>GSDMD</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MD51</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10412683</externalid>
        <name>CASP13</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O75601</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10320049</externalid>
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        </entity>
      </gene>
      <gene>
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        <name>MAPK7</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A5PKJ4</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353537</externalid>
        <name>TRIM25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLA8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349075</externalid>
        <name>HERC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPN8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10344801</externalid>
        <name>IL2RG</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q95118</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10323781</externalid>
        <name>TRAF6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q3ZCC3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420288</externalid>
        <name>LOC132342100</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353586</externalid>
        <name>LOC100139670</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>244102</externalid>
        <name>PSMD11</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2KI42</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389245</externalid>
        <name>FANCM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879471</externalid>
        <name>N(6)-carboxymethyl-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>53014</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>392385</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4-phosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>17526</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>708353</externalid>
        <name>muramyl dipeptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>59414</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>938700</externalid>
        <name>N(6)-(1-carboxyethyl)-L-lysine</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>60125</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>879504</externalid>
        <name>peptide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16670</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>38733</externalid>
        <name>ADP-L-glycero-D-manno-heptose</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15915</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9760917</externalid>
        <name>1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)</name>
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          <sourcename>ChEBI</sourcename>
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      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114745</externalid>
        <name>hydrogen peroxide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16240</externalid>
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      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
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      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
      <smallmolecule>
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          <sourcename>ChEBI</sourcename>
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    </smallmolecules>
    <linkedsystems>
      <linkedsystem>
        <externalid>R-BTA-913531</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-449147</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1170546</externalid>
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      <linkedsystem>
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      <linkedsystem>
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      </linkedsystem>
      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-1280215</externalid>
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        </linkedsystemtype>
      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-168256</externalid>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-913531</url>
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      <taxnode>
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        <taxonomyname>Bos taurus</taxonomyname>
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      <gene>
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      <gene>
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        <name>RNASEL</name>
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        <name>UBE2L6</name>
        <entity>
          <protein>
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              <sourcename>UniProt</sourcename>
              <externalid>A0A452DII5</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SFN</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q0VC36</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318946</externalid>
        <name>JAK2</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BCP6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389257</externalid>
        <name>FAAP100</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MJP8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10318941</externalid>
        <name>JAK1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N0D6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10326585</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MYF9</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353555</externalid>
        <name>FLNB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MQ34</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10345024</externalid>
        <name>MAP2K6</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q5E9X2</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
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        <name>SOCS1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MSN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347870</externalid>
        <name>LOC112447880</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LZ20</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>ISG15</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>O02741</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TYK2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>G3MYH9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>EIF4A3</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2NL22</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10346854</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LR94</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10392862</externalid>
        <name>DNAJC3</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N036</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10321324</externalid>
        <name>CENPS</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q2TBR7</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347409</externalid>
        <name>PIAS1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>Q24JZ9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>TRIM25</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A6QLA8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10349075</externalid>
        <name>HERC5</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPN8</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10420288</externalid>
        <name>LOC132342100</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MDI9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10359739</externalid>
        <name>EIF4G2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F2Z4C6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC100139670</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MM71</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376992</externalid>
        <name>ABCE1</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE6</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10353598</externalid>
        <name>MX2</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MZT4</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10389245</externalid>
        <name>FANCM</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1MLX2</externalid>
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          </protein>
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    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114751</externalid>
        <name>zinc(2+)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>29105</externalid>
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      <smallmolecule>
        <externalid>9735752</externalid>
        <name>adenosine 5'-monophosphate(2-)</name>
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          <sourcename>ChEBI</sourcename>
          <externalid>456215</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114918</externalid>
        <name>hydron</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15378</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9735751</externalid>
        <name>guanosine 5'-monophosphate(2-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58115</externalid>
        </xref>
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      <smallmolecule>
        <externalid>2023030</externalid>
        <name>lipopolysaccharide</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>16412</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>1422654</externalid>
        <name>diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>33019</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>6806373</externalid>
        <name>geranylgeranyl diphosphate(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>57533</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>15377</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>9736415</externalid>
        <name>GTP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>37565</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>8869364</externalid>
        <name>ATP(4-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>30616</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>2530487</externalid>
        <name>farnesyl diphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>50277</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>9736416</externalid>
        <name>GDP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>58189</externalid>
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      </smallmolecule>
      <smallmolecule>
        <externalid>5687611</externalid>
        <name>hydrogenphosphate</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>43474</externalid>
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      </smallmolecule>
    </smallmolecules>
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      <linkedsystem>
        <externalid>R-BTA-909733</externalid>
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      <linkedsystem>
        <externalid>R-BTA-877300</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1169410</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-9909505</externalid>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-HSA-913531</externalid>
        <linkedsystemtype>
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      </linkedsystem>
      <linkedsystem>
        <externalid>R-BTA-1280215</externalid>
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          <superset />
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    </linkedsystems>
  </biosystem>
  <biosystem>
    <externalid>R-BTA-909733</externalid>
    <name>Interferon alpha/beta signaling</name>
    <biosystemtype>
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    </biosystemtype>
    <description>computationally inferred pathway (not manually curated)</description>
    <url>http://www.reactome.org/content/detail/R-BTA-909733</url>
    <taxonomy>
      <taxnode>
        <taxid>9913</taxid>
        <taxonomyname>Bos taurus</taxonomyname>
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        <name>ISGF3G</name>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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          </protein>
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      <gene>
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      <gene>
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      <gene>
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        <name>LOC132345931</name>
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              <externalid>E1B7E8</externalid>
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      <gene>
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        <name>IFNAR1</name>
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      <gene>
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              <externalid>F1N339</externalid>
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          </protein>
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      <gene>
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        <name>LOC523244</name>
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          <protein>
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              <externalid>E1BDZ1</externalid>
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      <gene>
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        <name>STAT2</name>
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              <externalid>E1B8Z4</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>JAK1</name>
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          <protein>
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              <externalid>F1N0D6</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>PTPN1</name>
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              <externalid>A6QQN2</externalid>
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          </protein>
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      <gene>
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        <name>UBC</name>
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              <externalid>P0CH28</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>IFNAR2</name>
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              <externalid>F1MXT2</externalid>
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          </protein>
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      </gene>
      <gene>
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        <name>SOCS1</name>
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          <protein>
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              <externalid>F1MSN0</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>LOC112447880</name>
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      <gene>
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              <externalid>F1MCX4</externalid>
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          </protein>
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      <gene>
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        <name>PTPN6</name>
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              <externalid>A0A3Q1M739</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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              <externalid>G3MYH9</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>IFNAC</name>
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          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>F1N6A7</externalid>
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          </protein>
        </entity>
      </gene>
      <gene>
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        <name>UBB</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P0CG53</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347806</externalid>
        <name>LOC783912</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1MMI8</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311580</externalid>
        <name>UBA52</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P63048</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10347866</externalid>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A0A3Q1LPD3</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10311584</externalid>
        <name>RPS27A</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>P62992</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10333089</externalid>
        <name>KPNB1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>E1BFV0</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
      <gene>
        <externalid>10376992</externalid>
        <name>ABCE1</name>
        <entity>
          <protein>
            <xref>
              <sourcename>UniProt</sourcename>
              <externalid>A4IFE6</externalid>
            </xref>
          </protein>
        </entity>
      </gene>
    </genes>
    <smallmolecules>
      <smallmolecule>
        <externalid>8869367</externalid>
        <name>ADP(3-)</name>
        <xref>
          <sourcename>ChEBI</sourcename>
          <externalid>456216</externalid>
        </xref>
      </smallmolecule>
      <smallmolecule>
        <externalid>114728</externalid>
        <name>water</name>
        <xref>
          <sourcename>ChEBI</sourcename>
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        </xref>
      </smallmolecule>
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        <name>ATP(4-)</name>
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      </smallmolecule>
      <smallmolecule>
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        <name>hydrogenphosphate</name>
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    </smallmolecules>
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      <linkedsystem>
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        </linkedsystemtype>
      </linkedsystem>
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      </linkedsystem>
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      </linkedsystem>
    </linkedsystems>
  </biosystem>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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      <gene>
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